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1longevityxlab774Kmacroveryhighpost8100017546.5neutral2026-02-07longevityDr. Louisa Nicola didn’t come into brain health through theory…she came through ...No audio available↗
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@keithmason_officialIf sleep debt can’t be reversed then what’s the pointnegative
∟ @okmerge@keithmason_official right, I’m 4mo postpartum over here ready to go lift weights then swipe to see “sleep debt cannot be repaid”…RIP to the parents 😂😢 this post just brought me up & down a motivation roller coaster.negative
∟ @lance_jantjies@keithmason_official came here for this comment as a new parent who no longer has complete control over my sleep during this phase early phase of parenthood I don’t see any info on Dr.Louisa being a parent(stand under correction). So the damage is done and can’t be repaired? ?negative
@tarahoneycuttOmega 3 recommendation? ?neutral
@themillennialkitchenCreatin hydrochloride or monohydrate Do 2 gms hcl or 5 monohydrate? Please guide if sufficient or tweak ? 🙏🏼 ?negative
∟ @themillennialkitchen@themillennialkitchen do guide creatine hydrochloride v/s creatine monohydrate and comparative equivalent dosage. We have creapure from Germany here in 🇮🇳neutral
@olive.siSo all that sleep I lost during pregnancy and postpartum is going to make me more vulnerable to this disease? ?negative
@cindymcabee1120g of creatine? I can’t find any product that says more than 5g daily. Doesn’t 20g seem high? ?negative
@jessicasmith27Would be really interesting to see some actual studies that relate specifically to sleep deprived parents. Im genuinely curious as a mum of 3. Why haven’t studies been done yet? If sleep is so crucial I’d been interested to know the impact of sleep deprivation. Because I haven’t had a night of unbroken sleep in ten years. Not complaining. But keen to understand the damage it’s caused ? Do any studies exist? ?neutral
∟ @hansen_emma@jessicasmith27 I'm happy to partake in this study! Love my kids, but sleep has been disturbed/broken since 2012positive
∟ @themom_loek@jessicasmith27 I was just thinking the same thing. Not to critique this post but genuinely want to know what we can do as moms that are sleep deprived? How do we recover from the damage of sleep deprivation? @longevityxlab Could we perhaps get a follow up research if at possible? ?neutral
@ageingstrongerWill watch. My Mum has altzheimers and I am 63 and am doing everything I can to protect my brain and healthneutral
∟ @skylarolson@ageingstronger try RetainYourBrain.com! It was developed by a preventive neurologist Dr Richard Isaacson to help manage Alzheimer’s risk factors and make healthy lifestyle choices! It’s free too :)positive
@ruthrizaSo weird, my mom only had OA, nothing else in her entire life, not even HBP and still developed Alzheimer’s!😥🤦‍♀️🙈🤔negative
∟ @_aliwags@ruthriza I’m sorry to hear that 😢. Do you know what her A1c, fasting insulin and triglycerides are/were (if still living)? Toxic load is also important but insulin resistance seems to be one of the most notable causes ?neutral
@elizabethzaedowCan you share what is misleading? I'm curious to know your thoughts ?neutral
@newell156GP’s learn little to nothing about nutritional therapy. Their medical protocols are very outdated and inadequate. Take away their big pharma proscription pads and they have are at a loss.negative
@majid.ktalI do 10-15g a day. It’s amazing.positive
@shieldsfam4I am also reading about creatine being tough on kidneys but I do is conflicting or unclear.neutral
@mark_engberink20g is tested on patient. Maybe they need more, for prevention is less enough? ?neutral
@thebrilife_I use Thorne as well. I do 10 twice a day. Start with 5 and go up by 5 every third day until you are at 20.positive
@jbutlerfounderA lot of people are going to end up on the kidney transplant list when their renal function is damaged from high creatinine levels. But 20 g sounds perfect for brain health while you’re on dialysis for your kidneys! 💯neutral
@xbeastedThere is a polygenic risk for Alzheimers. In large biobank studies only 50% of cases are shown to be preventable... which is still a lot!neutral
∟ @xbeasted@xbeasted totally love the message about lifting heavy. Id love to see the 95% sourcepositive
∟ @ssrocha.88 to @okmerge@okmerge Exactly the same, 4 month pp, second baby. Always laugh when people say "you need to sleep to not get dementia". Sure, that would be great 😂positive
∟ @byagnessa to @okmerge@okmerge yet at the same time other reaserch shows that having more children and being a parent to small kids later in life makes your brain work better because it „exercises”.neutral
∟ @jodynorton60 to @wellnesswarrior@wellnesswarrior.ie that is so true! I have below average functioning kidneys, and MD said it could have damaged themnegative
∟ @jessicasmith27 to @hansen_emma@hansen_emma seems as though we’re always overlooked in the research.. and yet it seems we’re also the most at risk / vulnerable 🤷🏼‍♀️negative
∟ @jin_e_yoga to @longevityxlab@longevityxlab incredibly informative podcast with practical advice!positive
∟ @leoadams to @louisanicola_@louisanicola_ Thank you for the excellent info. We should be refrigerating fish oil/omega 3s? If we haven’t been should we throw it out and start over? ?positive
∟ @sandeeee66 to @louisanicola_@louisanicola_ what is your take on the APOE4 gene? People that get alzheimer's that dont have the gene its caused by lifestyle and diet(not to mention the other types of neurodegenative dieases) ?neutral
∟ @videologistclicks to @louisanicola_@louisanicola_ is 20g or is it enough to do the 5g daily for young people? ?neutral
∟ @yungcangco to @louisanicola_@louisanicola_ isn’t 20g of creatine for a daily intake high? ?neutral
∟ @iamsassy_sv to @_aliwags@_aliwags exactly that when I think of my mum's dementia and she had type 1 diabetes!negative
∟ @fnxnutritionuk to @_aliwags@_aliwags my thoughts exactlypositive
∟ @lifeis2short_toputup_withfools to @lifeis2short_toputup_withfools@lifeis2short_toputup_withfools and staying away from cannabis and marihuana… those contribute to dementia and other drugs to schizophrenia, etc… plus nutrition, plus keep on learning, hobbies, etc.. it’s not as simple as just doing leg exercisesnegative
∟ @nmllr81 to @ryan_wulfhaus@ryan_wulfhaus watch Dr.Candow. he's apparently the leading scientist on creatine research. Matt delauer has done really good interviews with him. Candow talks about 5,10 and 20 grams of creatinepositive
∟ @iamlewiscooke85 to @butlerelevated@butlerelevated if eGFR is fine then that is a better indicator of overall kidney health as it takes into account multiple factors. Creatinine levels should definitely be monitored, but they will likely always run high in those that train, especially those with above average muscle massneutral
∟ @jbutlerfounder to @iamlewiscooke85@iamlewiscooke85 @thebrilife_ Chronic 20 g/day fundamentally alters the risk equation. Excess creatine increases creatinine generation, undermining the reliability of creatinine-based eGFR, even in well-hydrated, physically active people. Yes, athletes and physically fit individuals often have higher baseline creatinine. That is normal. What is not normal is chronically elevating it through sustained overconsumption of creatine. Hydration may blunt fluctuations, but it does not preserve renal reserve or restore diagnostic clarity. That creates a blind spot where kidney stress progresses silently until routine stressors like heat, illness, and NSAIDs trigger overt injury or accelerated CKD, often after reversibility is lost. This is why ~3–5 g/day is the documented, evidence-based maintenance dose. At that level, muscle creatine stores are saturated and renal clearance remains stable. Doses far beyond this provide no additional benefit and simply increase the amount the kidneys must excrete. The excess doesn’t ‘go to the brain’ or muscle. It becomes filtration work. That’s also why prolonged loading phases are increasingly discouraged. They add clearance burden without added physiological upside. Framing chronic high-dose use as a long-term ‘brain health’ strategy is irresponsible without empirical, longitudinal evidence. We’ve seen this pattern repeatedly with diet and wellness extremes: very-low-calorie liquid protein diets, detox and cleanse regimens, high-oxalate juicing, and extreme ketogenic protocols all produced documented kidney or liver injury when balance was abandoned. The failure was never the concept itself, but the assumption that more, harder, or longer must be better. Absence of immediate harm is not proof of long-term safety.negative
∟ @jbutlerfounder to @iamlewiscooke85@iamlewiscooke85 I respect what you’re saying and not trying to argue. Just providing deeper insight because these platforms will have people convinced that “experts” are giving sound advice on their problems. There’s often significant details missing in the pursuit of expediency and opinion. I certainly hope you have a great rest of your weekend and appreciate the dialogue.positive
∟ @kbuck___ to @butlerelevated@butlerelevated when I personally was cycling 20g a day I was getting extreme dizziness. Didn't know what it was from at first. I stopped the high creatine dose, and it went awaynegative
∟ @meaker to @snowboarderf17@snowboarderf17 I do. I make a point to do so. I can tell a difference when I don’t.positive
∟ @teegan_paulin to @snowboarderf17@snowboarderf17 I agree. But it does make sense if you think about the increased dementia. People used to sleep similarly to the cycle of sunlight.neutral
∟ @socks_n_moccs to @tilla260390@tilla260390 ive also read about this. You think strong metabolic flexibility is an important protective / preventative tool? I was hoping to see that mentioned in this post ?positive
∟ @mlc_cope to @tilla260390@tilla260390 yes, I've heard it's type 3 diabetesneutral