| 1 | Anu Test Tube Baby Centre | Decoding the link : Immunomodulation and invitro fertilization (IVF) | 444 | 12 | 1 | 53.5 | negative | 4:24 | Hello friends, I am Dr. Anurada, Patelitis Specialist from Anu Bestu Baby Centre, Hyderabad. We are going to discuss the role of immunomodilitary properties of registrant for successful IVF cycles. Most of the IVF cycles utilize control ovarian stimulation protocols which require bono-rotropping releasing hormone analogs. The use of GNRH analogs causes pituitary suppression leading to a dysfunction of the dysfunction of the purpose of lithium and reduced progesterone levels in the luteal phase. So how do you recognize the luteal phase deficiency? Which can be detected by low progesterone levels, delayed and novitual secretary trans commission and a shortened luteal phase of less than 10 days, resulting in reduced embryo implantation, low pregnancy phase and increased miscarriage rates. So, this necessitates a luteal phase support to enhance the probability of continuation of pregnancy in IVF cycles. In the luteal phase, endogenous registrant induces a secretary trans commission of the endometrium after adequate estrogen priming and improves endometrial receptivity. The reduced endometrial receptivity would cause a lower impractation rates and low success rates in IVF. In pregnancy, the maternal immune response is modulated away from the cellular that is a TH1 response and towards human eliminated that is TH2 response to produce antibodies. In addition, cytotoxicity mediated by non-specific natural killer cells is dampened by the inhibition of TH1 cells which produce cytokines such as interleukin-2 and interferogama. Activation of NK cells is known to result in fetal resorption. Thus, there is a bias towards the production of TH2 cells in pregnancy, which may be a productive mechanism to promote fetal survival. Dihydrogen strong is a progesterogen which is potent, oral active and is similar to endogenous progesterone in its molecular structure and pharmacological effect. It acts via the progesterone receptor to produce a 34kd mediator protein called progesterone induced blocking fracture, that is PI-BF, which mediates the immunomodulatory effects of progesterone during pregnancy. Progesterone induced blocking factor also induces the TH1 TH2 pregnancy protective cytokinescence. Moreover, PI-BF suppresses NK cell activity by inhibiting, perfuring exo-cytosis and increases the synthesis of asymmetric antibodies that can mask featureally derived antigens without activating the complement system, phagocyteosis or cytotoxicity. And therefore, plays an essential role in the immunological defense of the fetus. So to conclude, hydrogesterone induces an embryo protective immunovodulation, inducing to the success of pregnancy. I have been using hydrogesterone for the last 25 years, for most of my IVF patients, my name for the LIT patients, unhesitantly and confidently, unless there are some contraindications, or if the patient is not able to tolerate the drug. The next session will be on maintaining TH1 and TH2 balance and its impact on IVF substance rate by my fellow colleague. | ↗ |