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1r/BestofRedditorUpdatesAITAH for taking away my dad’s girlfriend’s keys after she tried to send me to b...Cheap-Rate-899640090%67582.5PRP knee treatment2026-03-14↗
commentercommentsentimentupvotes
u/BrainjackerWe consider maybe it was just a weird millennial thing, the way she texts 😒4759
u/dinoooooooooos“Weird millennial thing” Why tf we catching strays for. The fuck.2383
u/Single_Vacation427They are creating the problem themselves by inviting her to this "gala" and replying to her crazy messages.2170
u/HomeLibrarian1338Well if it IS a real story March/April marks 9 months since the last update so maybe we'll find out: -Is Sorrel pregnant? -Did Henri ever go to the ultrasound appt? -Did Henri figure out that Sorrel (who apparently also works in his field) only got together with his father in an attempt to get closer to and seduce him? -Will any of them grow a backbone and tell the psycho-woman that she is not actually related to any of them and therefore she needs to stay away from them? Find out next time on Dragonball - I mean BORU!1334
u/offputtingangeli love reading long posts where every single detail is included, even the ones that i wouldn’t think to ask for. idk, maybe i’m just way too nosy for my own good?? op used paragraphs, punctuation and even a little bit of french. this was an easy read. it kinda reminds me of those french films with an unsettling vibe where something is wrong but you just can’t put your finger on it and nothing really happens for long periods of time. the film would of course be left open ended and viewers would complain about the ending as always happens with open endings. i do hope that this ending isn’t open though, it would be nice to get an update where sorrel is not pregnant, just crazy and removed from the families lives for good.1315
u/itsricwolfSorr-el no!960
u/pray4mojo2020It's weird that I just read so much, and yet we still don't know: - anything about the younger kids' mother, if she's alive or why she's not around, how long she's been out of the picture - whether they've always lived with the uncle, or if they lived with the father for any period of time - whether the father's contact is a recent development or if he's always been allowed to just kinda be around despite having lost full legal custody - why the uncle is gone so much even though he's the sole legal guardian of the minor children - are they all French except for the gf? Did they live in France for part of their lives but now they live somewhere else? (Not really important but I'm just confused about the context of Sorrel mocking her accent.) I don't know, did I miss it? I'm not advocating for this thing being even longer, it just seems weird that I'm left with so many questions after reading for so long.602
u/AlisterSinclair2002''Grab your popcorn'' is like a golden badge telling you the rest of the post(s) will be total bs lol465
u/TaliniaI could have sworn I'd already read this update, but I guess the last one was the discovery of the "pregnancy" and this one is just that OOP is suspicious of it. OOP is pretty active though, so kinda surprised there's nothing in the last 8 months either way426
u/WeeklyConversation8Unless she's very high risk, or having medical issues, OB appointments aren't weekly. They are monthly. If this is real, she's trying to be their Mom.370
u/SpillThatTea2MeOh geez. OP is getting pushed out of her own family. Hopefully her brothers and uncles have her back like she thinks they do or she’s screwed.323
u/KerbartI'm confused about OP's disenfranchised father whose been a drunk and out of her life and only reconnected a year before the events happened. Yet he's a street car racer who taught her driving and she "knows him to the bone." It just doesn't add up.274
u/LeftieswillruleThis story was less interesting than I hoped.175
u/fndnvolusrgofksbI read the entire popcorn post and nothing happens. You learn op is French, that's it. Everyone else acts completely as expected. OP yaps on and on about every single family picture taken and how nice her car is. (Context she does not know the meaning of the word concise) Your brain cells discover that there is a way out through your ears.151
u/CrimeislegalSo much text with so little actually important information....114
u/AstrosaucedSome people have too much time on their hands.106
u/Response-GladNot the first time a step mom figure has gotten weirdly jealous of their step daughter. Gross. In this case it sounds like this woman can't conceptualize at all what growing up in this family has been like or the parenting OP had to do early. She definitely doesn't get it since she decided to have a baby with dad despite everything she has seen. I wonder how much minimizing the story Dad has done. Doesn't seem like he has ever really taken accountability. However, sounds like OP has done a truly incredible job for her family. She shouldn't have had to grow up so young, but she did so well against all of the odds. She should be proud of herself and trust her gut.98
u/LeadmeNotFLLISTEN, CHARLIE, GET YOUR ASS BACK ON REDDIT AND FINISH THE STORY! I don't read long post, but I read every sentence of your posts and you didn't even give us a conclusion??? Non mais sérieux… c’est quoi ça ? Montre un peu de respect aux lecteurs et reviens ici. Ugh!93
u/dropshortreaverI cant put my finger on anything definite, but something about this is activating by BS meter86
u/DougSpeagleThe uncle has full custody but also doesn't seem to exist in the physical world somehow84
u/MargotBamborough[removed]65
u/Tangled2I learned driving from my dad, he used to be a street racer. This is just the dumbest shit. But, I mean, the whole saga is an idiot plot. “Dad, Sorrel is overstepping and bugging the living shit out of us. I’m not saying you have to break up, but If you keep bringing her around then neither of you will be invited to anything ever again.”64
u/Accomplished_Cod7613Definitely felt like I was reading a story arch from Shameless with this.60
u/Key_Possibility_8669Am I the only one that got surprised by the fact that the two youngest siblings have a different mother? Where is she, and why isn't she involved in the children's lives?57
u/MinionsHaveWonOneI was skeptical but enjoying the ride until OOP reached into the glove box for a highly convenient key that was surplus to requirements but luckily closely resembled the key she'd taken off Sorrel. And "accidently" grabbed $5 (I know my glovebox is stuffed with $5 notes) so she could conveniently shove it at Dad with a snarky remark. My disbelief can no longer be suspended.37
u/Both-Condition2553“I raised them too” from a girlfriend of six months is wild.28
u/SebscreenSorrel is obviously terrible. But I cannot get over how spineless OOP and her brothers are.  They hold all the cards. Yet, they allow themselves to be condescended to and disrespected again and again and again. They should have burned their relationship with their awful dad and his awful gf a long time ago.28
u/LivSaJoIf the baby existed it would be born by now. I hope we get an update24
u/1quincytooNow I want to rewatch Shameless22
u/Divinemango7They had me until the second post and they said “story time!” And it was a four day window.20
u/nobonesjones91That bullshit should have been shut down immediately16
u/mixedwithmonetIdk what I’m taking away from reading all this except people really need to start being meaner.16
u/bangbangrosieI would pay almost anything to see those photos from the gala.15
u/violueOkay when it got to the part with the jars it stopped being fun. I feel really bad for OOP and the fact that if the pregnancy is legit this terrible woman is going to be a permanent part of her life. Considering how low their opinion of their father is, I'm surprised they've all been willing to put up with Sorrel?? Is it for his sake??15
u/Maximum-Ear1745This was hard to read. I would have shut down communication much much earlier.14
u/PickupyoheelI just wanna see the car14
u/PissedliberalgrannyI really hope she updates this at least one more time so we can find out if Sorrel was ever actually pregnant and whether or not the potential baby was Anatole’s. Updateme12
u/comomellamoThis is nuts. The "dad" has no legal rights to the younger siblings so they should just cut contact with him and his gf. When the Uncle is back in town he can deal with his brother.11
u/Jack0fTh3TrAd3sThe most spineless family on earth. This whole thing would have been done and quashed with a simple "if she's here, you're not welcome" to the dad. Either he leaves and no harm no foul, or he leaves her, a win for the family.11
u/Allergictosquirrels“i’m no longer investing energy into enduring your behavior.” What a line 🤌9
u/Used-Cup-6055So daddio has five children he has never had custody of and having a sixth one? Why do I feel like this baby is going to end up on the uncle’s porch at some point in the future?8
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2r/HotScienceNewsCompulsive behavior is caused by brain inflammation - not bad habitssoulpost23520%14082.5stem cell therapy2026-03-09↗
commentercommentsentimentupvotes
u/fhwoompableCooperHuge news tbh125
u/babyhuffingtonThis makes sense based on common symptoms seen with people who have experienced a traumatic brain injury like myself. I’ve noticed that I can go through phases where I keep repeating the same thoughts in my head and I’ve noticed that it’s tied to when I’m sick. This makes it hard to seek out therapy because when I tell a therapist about it, they completely dismiss it. I have to keep it all to myself because no one understands.99
u/Fuzzy-Albatross-9206So how do we decrease inflammation95
u/thebigyin3This does correspond with what is seen clinically but as always need to be careful in attributing causation.48
u/Ok-Rule9973The scientific article doesn't state that people with OCD have heightened inflammation, but that inflammation can cause OCD-like behaviors... In rats, and in controlled situations. It's a very big leap to say that OCD is caused by inflammation. We know that human behaviour is extremely complex, it should not be reduced to a single factor like that except when the science actually back this. And I'm not sure about whom said that compulsive behaviors where a sign of loss of control. I've always read that it was overcontrol.20
u/neatyouth44YES! And it can be ironically made worse if encountering “focus on what you can control” language in therapy right off the bat. Same with eating disorders. We need to be careful about “calming” people into pacification of damaging and abusive environments, though. And that is very hard to seperate from systemic misogyny or patriarchy (harming both men and women, to be clear).12
u/Otherwise_Cry95A lot of cases are caused by past strep infection and the resulting inflammation effecting the brain’s basal ganglia.4
u/Bababooey0326Glad this is finally being discussed and recognized by medical powers that be Diet/gut you are what you eat. The improvements you will find within yourself once what you put in your body is under control? It's miraculous.  Inflammation is key to so many issues4
u/InteractionGreedy249The brain inflamed will mainly go insane.3
u/skyfishgoocooler heads truly do prevail perhaps the answer is as simple a taking beat to let the swelling go down before you make any life changing decisions. this sounds like ancient wisdom even tho they probably had no idea about the actual mechanics involved.3
u/Mountain_Elk_7262So how do we increase inflammation enough to motivate but keep it under enough control to mitigate the potential down sides?3
u/Ardent_ScholarMy word. This must be why glp-1s lessens obsessions with food, caffeine, booze, gambling, etc.3
u/GravyMealTeam6I wonder if this is another reason why GLP1 drugs help addictions. Not just cause of the dopamine aspect but also they are anti inflammatory3
u/Dedicated2bMedicatedSo how do us with ADHD increase inflammation3
u/secondrunnerupIs this why GLP-1s are having an effect on people’s smoking and drinking habits? From what I understand they are anti-inflammatory.2
u/Forward_Motion17How many times do I have to say psychiatry and psychology need to move in to a “whole-body” model before it’s taken seriously smh2
u/Overlord7193Seems promising but still needs work based on my lived experience with ocd.2
u/TemporaryElk5202Sweet jesus I swear I have felt so crazy explaining to doctors and autoimmune neurologists that my OCD gets better with anti-inflammatories, and gets worse alongside my autoimmune disorders.2
u/AttorneyUpstairs4457I knew this to be true for years! I have very pronounced compulsions to research health solutions to my problems when I’m experiencing brainfog (neuro inflammation). Think doom scrolling down rabbit holes instead of sleeping m or cooking/cleaning. I’ve finally discovered that my inflammation is caused by SIBO which I’m trying to treat.2
u/[deleted]For years, the scientific consensus was that compulsive behaviors like repeated handwashing or gambling were simply "autopilot" habits that overrode a person's self-control. As someone who's lived with OCD for several years as well as a couple other disorders that are even more misunderstood.. The shit scientists believe just really baffles me sometimes. You can just ask us, it's very clearly not an autopilot thing. It's the complete opposite, you are incredibly aware to the point that it's intensely uncomfortable and completely overwhelming How on earth did they ever think it was an autopilot behaviour?! Did they even bother to ask people who have OCD what its like? 😂2
u/peterjohnvernon936Often enough there is a reason for bad behavior other than the person being evil.2
u/baaaananaaaI have intrusive thoughts and take things like ashgawandha and NAC, glycine etc to ‘calm’ my head. I don’t think inflammation is the reason for intrusive thoughts but likely can make it worse. When I gave birth, my hormones made my intrusive thoughts unbearable. It was literally like torturing myself with thoughts about things going wrong, that were completely unrealistic.1
u/SGT_KPYea, BUT if I don't continue my behaviors and habits, then I may become a bad person. But then again, I would be a bad person if I didn't try to better myself. So, I'll try to better myself. But if I better myself then I won't be doing my habits, and then I'll be a bad person...1
u/TheShimmeringCircusSo anxiety/OCD based behaviors stem from trying to control and seek out less scary outcomes? Shocked… I’m shocked, I tell you.1
u/glunky_womboI thought this was all already known 😭1
u/Visible_Fill_6699Wait so the ambitious go getters could simply be suffering from brain inflammation?1
u/CatOnKeyboardInSpaceTake two ibuprofen. If your mood improves and you can think more clearly, maybe the reduced inflammation helped.1
u/Wooden_Try1120Compulsive disorders are not impulse disorders. I think we already knew that.1
u/Fun-Birthday-4733Celiac disease should be tested for at birth1
u/ColonelSpacePirateWhat are the bio markers for brain inflammation?1
u/ImAVibrationLikely why the keto diet, which reduces inflammation, is so well connected to mental health improvements.1
u/BaronOfTieveYeah this makes complete sense as someone with OCD; my OCD is 100x worse when I’m stressed or sick.1
u/Lurk-ProwlVery interesting and great work from an Aussie uni to have come out with. I’d like to know how inflammation was measured and how this can be reduced. For instance, skin inflammation can be reduced with drugs like prednisone, but there are side effects. Other people claim that diet helps them reduce inflammation, but perhaps it depends on the cause and area of inflammation.1
u/Ok_Yellow_4862Muscle spasm causes compulsive movement and thoughts. "Working out/unraveling" the spasm so that it no longer controls. OCD behaviors may also decrease inflammation short term, but does sticking through/going all out on the behaviors (as opposed to stopping them) ever result in cessation of the behaviors? I.e. are they becoming ingrained, or are they a necessary tool to reprogram the brain? I like "misguided" being used in the article, bc with other help or support that could "change the overall environment or system" the ocd behaviors may become unnecessary.1
u/Funkmaster74Today's edition of Obvious News.1
u/strawberry_lr/M_Determinism r/Determinism1
u/Formal_Economist7342The word inflammation is used kind of um confusingly here.1
u/Resident-Age-8844Does this include compulsive liars?1
u/archives2024Inflammation is the root of all disease.-1
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3r/BORUpdatesAITAH For Being Upset that I am treated differently than my siblings?BigONerd16080%16382.5PRP knee treatment2026-03-09↗
commentercommentsentimentupvotes
u/Impossible_Flight290Goddamn OOP needs to remove her parents and siblings from her life before it affects her kids more1694
u/Vast-Swimmer5844When I explained to my Father why I turn down invites to family holidays I said "Why would you expect me to show up and act like family so that I can sit there and be treated like I'm not?" and he looked me in the eyes with the saddest expression and said "She doesn't treat me much like family, either." So fucking what? He chose that hag. The OOP had no choice here. May the OOP finally yeet her kids from family visits, and may her parents and siblings all reap what they sowed.425
u/HUNGWHITEBOI25Man i just don’t know why OOP keeps in contact with these awful people. They all sound terrible310
u/murdocjonesShe’s giving her siblings too much credit. There’s really only so long that an adult gets to correlate their behavior to how they were raised. At a certain point, you’re old enough to know better. If they could treat her children well, they could have treated her better. They just chose not to.289
u/ChrisInBliss... I dont understand how the sisters couldnt realize WHY OOP was so hurt. Even after them having a siblings trip WITHOUT OOP and being snobby about it. Like NO these grown adults knew what they were doing. Yes it was normalized but they still KNEW153
u/disgruntled_cat_Well this is horrible.87
u/less_than_nickWatching her try to defend her sisters gross past behavior at the end was so frustrating. Can't believe she's giving these assholes so much grace75
u/LadyNorbertI'm also in constant pain, and spent my entire childhood dealing with the antics of a violent alcoholic. I would rather eat glass than treat someone the way this OOP's mother has treated her.59
u/snootnootsShe’s still being such a doormat, ye gods. 🤦‍♀️ And she’s basically trickle-truthing herself about how bad it is. “Oh my mother treats me terribly, but she dotes on my children and doesn’t treat them any worse than her other grandchildren! Except for the birthday dinner thing. Well actually it turns out she’s body shaming the oldest, but she’s awesome to my middle child! Well actually she says snarky things in earshot of her all the time, but it doesn’t affect her at all. Well actually she remembers it all and can repeat it but I’m sure it doesn’t actually bother her, so I’m gonna keep letting my child go hang out with my mother after school. I’m not trusting her with my kids! I’m still letting her spend tons of time with one of them because it’s convenient for me, but I told my father that I don’t trust her to be safe or sane around them and I’m monitoring the situation VERY closely! Just not, y’know, doing anything.”41
u/lizzyoteI get why people dont want OP to let her siblings off the hook but i get why OP is hesitant. OP is having her entire life fractured by new realizations about her family. Thats scary af. Its hard to cut off family in normal circumstances. Shes had nearly 40yrs of one kind of reality and now everything is changing. I hope her spouse and kids continue to be a supportive family unit.25
u/Some_External4457Reads like a hopeful update until you realize she’s still completely enmeshed and making excuses for all of them. Her mom called her daughter a pig and she’s still giving her mom access to the kids. Her sisters never apologized for being jerks about the trip but she’s convinced herself they’ve changed. In 15 years we’ll be seeing a post from OOP’s daughter asking if she’s TA for wanting to go no contact with her abusive grandmother and enabling mother. It’s sad.24
u/z-eldapinJesus, OOP needs to move far away and change her number. Zero access to any of these horrible people.23
u/mmanyquestionssyeah she needs to cut contact with every single member of this family except maybe the nieces and nephews13
u/glitzglamglueFirst paragraph: OMG grow up. You're 38. Why do you care so much about birthdays? Everything else: nevermind. You were right.13
u/stanloonathxDespite going NC with the mom and LC with the others, I think OOP still subconsciously wants a connection to her family. If she's been treated like that throughout her life it's hard to let go of that desire to be seen and accepted by people who normally would love you (because family). So it's not just her father and her sisters who need to unlearn shit, but her too. Because it's now affecting her kids. If she doesn't cut them off completely her kids will continue to see and hear things from her mother that will hurt them more.10
u/justaheatattackyou know, you can throw your own party. you don't even need a reason. you don't even need anyone else to show up. ask me how I know!10
u/moontiara16OOP keeps saying her middle child is not effected by NMom’s behavior. Meanwhile, OOP had no idea NMom was calling eldest “piggy” and “oinker.” OOP is doing better but damn, she’s still allowing caustic behavior. Edit: missed a word8
u/Due_Enthusiasm1145I know a lot of people will be quick to tell OOP to cut off everyone, but honestly I completely understand her mindset around her sisters. She acknowledges she has every right to cut them off, and at no point indicates any obligation to them. Instead, her reasoning for low contact is that they are showing massive improvement compared to where they were, and that while she's watching carefully for any disrespectful or hostile behavior, she hasn't seen any or expects any. She also acknowledges she'd cut them off instantly if she received any. The fact that they haven't apologized sucks, but again if they are treating her well now, I think at that point its no longer a "you should cut them off" and more a "you could cut them off". The choice is hers and I understand it, even if I may have made a different choice in her position. The father is more messy, because there's finances involved there.8
u/GeneralPhilosophy691Honestly, OOP is being dumb by not biting the bullet and moving. Her dad is still her landlord, and eventually her mom will get pissed off enough to get him to evict her/not renew her lease unless she "comes to her senses and attends family gatherings" again. She doesn't have a lot of power in this situation because of that.7
u/XemptOne56OOPs mom sounds very unpleasant to be around. She is projecting hardcore...6
u/ceejreadHer middle child is going to either develop a people pleasing need to avoid getting the kind of snide comments and freezing out that she sees/hears from grandma, or she’s going to be encouraged to disrespect her parents and family because grandma manipulates her into seeing them as the problem. It’s a shame if she enjoys her time with grandparents, but by the time it’s clear there’s a problem and contact stops, the damage might not be reversible. Also I give OOP grace with her siblings. They are all operating under the theory that if isn’t the outright emotional abuse the mother does, it’s not abuse or worthy of an apology. Hopefully she gets stronger and realises that ignorance does not excuse repeated poor behaviour.6
u/fionsichordSadly, when a set of siblings is raised in such dysfunction- alcoholic, checked out dad and a conflict-addicted mother - the siblings are shaped by that and it can be hard to impossible to really let go of all the misinformation you used to build your image of that person. Without a bunch of really top-notch therapy over a fairly extended period of time, OOP is better off lowering or cutting contact and reevaluating her expectations of what it’s possible to achieve in a relationship with them. I had to give up my dream of maybe being the one who got my family to connect more genuinely or securely. Enough of the older people had already decided my role in the system and I’m only now realising that a lot of them have an idea of me that’s very different to how I’d see myself, but which would explain my difficulty in connecting to many of them and why they don’t reach out to me.6
u/PracticeTheoryHey, this was my mother in her family! Down to the mean spirited mother than used cooking as a weapon and a spineless father. Along with the abuse she suffered growing up (called things like 'ugly duckling', 'big nose', made to do the most chores, and stay silent as her siblings were given more), it was also put on her kids. It was as if the harder my mom yearned for her approval and tried to please her, the more it disgusted her. The first way it came towards us was that after agreeing to babysit me so my mom could go back to work (at the time my mom believed having a grandchild would mend their relationship)...the week after I was born, the woman went out and got the first job she'd ever had, and kept it just until I was accepted into daycare a couple of years later. This pushed my parents to reconnect with my dad's estranged mother, who watched me instead and I love and cherish to this day. When my mom's mom found out, she screamed at nice grandma in the middle of the grocery store for ruining her scheme to screw over my mom. Nasty!grandma went on to babysit all five of my cousins. My mom still wanted us to have a relationship with her, so she'd still bring us over on some weekends. I hated going because she only served us freezerburnt corndogs that came from a huge bag that wasn't touched in between our visits. Not that the company was much of a draw either, since all I saw was a bitter, lazy woman. At the witch's funeral, all of my cousins, aunts, and uncles reminisced about how good her food was and how much she loved to feed people. And me and my sister just looked at each other wondering if they were talking about someone else. Because accordingly to all these people that woman had kindness in her, but we never saw it. I wasn't sad when she died. I had/have a loving grandma and it wasn't that one. We'd spent years on years telling my mother that she deserved better than she got and I don't think she was all that sad in the end, either.6
u/itsjustmo_My own mother could have written this same post. The people who told her she has to run now to protect her kids are right. What OP is too lost in the FOG to recognize is that when her mother is gone, the entire family system is going to turn on her all over again. I'm a probate paralegal on top of my personal experience. Its a Canon event and we cannot interfere. If the mom is using her pain as an excuse, the recognition and full accounting of what it was like to be her children will come only once the excuse of her pain is gone and buried with her.6
u/AgonistPhDI am baffled as to why the OP doesn't just move and cut contact with all of them.6
u/Fly0verThis is NOT to excuse the dads actions, but potentially relevant to those who don’t deal with alcoholism: Recently I was let go from a very VERY toxic job that had done a lot to hurt me for a long time. My sponsor (in case anyone doesn’t understand: my sponsor in sobriety from alcoholism) asked me to examine why I stayed for so long so I can address the situation in the future if it comes up again. She pointed out that she did the same thing and how many of us sober alcoholics choose to stay in abusive situations because we’re atoning for our previous actions; we think we deserve less than nothing from others.  Again, NOT EXCUSING the dad. I can let anything towards myself go until it hurts someone I love, so I would never in a million years act like him.  But my sisters, who aren’t alcoholics but grew up needing to placate my dad, see things as “that’s just how he is.” They stand up to him when it’s in regard to their husbands and kids, but it’s very easy to feel like “this doesn’t hurt me because I’m used to it, so why rock the boat” when you’re raised in an abusive household.  Dad unfortunately very probably thinks he deserves mistreatment and is used to this dynamic, so rocking the boat feels more painful — even when standing up for his kids — than just dealing with the situation, especially if he can’t gain the self respect to see that he also doesn’t deserve this treatment.5
u/thematicturkeyI wonder if things changed when her dad got sober. Maybe he was the target before OOP, just like now Mom is looking for someone new to target5
u/SharMaraliI wonder if OOP ever tried asking to have her birthday celebrated on a completely different day, like in June or something. I’m only wondering what kind of excuse her mother would’ve come up with. I definitely know this wouldn’t have solved the problem. It just would’ve been fun to see the mother try to spin a story about why it’s so important to celebrate on the actual birthday and then continue to not celebrate because it’s too inconvenient for her.5
u/PuzzleheadedTap4484Just wow… and I don’t agree letting the middle child go because she’s too young to understand OOP’s mother’s snide remarks. Kids know and understand. She may not understand the words but she understands the tone. And when she gets older she’ll reflect on the words and understand. I would have removed them from that toxicity and also moved away from mom and dad being landlords. In 9 months I’m sure they would have found something else, even if it’s not as ideal, it would be better than the toxicity.5
u/deedeejayzeeI have a "suicide " disease and don't treat people like crap all the time. I might say something in a harsher tone than I meant to, but I immediately apologize. If you're in pain, it doesn't give you the right to cause pain for others4
u/Zealousideal_Tea5988My dad was also in chronic, untreatable pain. Never once did that man yell or scream, hit or ignore me. Much less blame any of his actions on his pain levels. Stop giving excuses for crappy behavior that is a choice. Think better of yourself OP, and your kids...4
u/Moist_DrippingsTo anybody being treated this poorly by your parents: your kids are NOT flourishing if they are routinely sent to visit someone who is openly abusive, even if they are only abusive to you. That tells them that that behavior is okay (from multiple angles). For your kids’ sakes, do not allow them time with abusive grandparents, no matter how much you think/believe/hope they will be kinder to them. Do not let them see that they should give any allowances or make any company with someone who will abuse you, or they may think they should act the same way and allow it to happen to them.4
u/Similar-Shame7517Yeah... I don't trust OOP's father and sisters to not continue to be her mother's puppets.4
u/ThingFabulous2336God I needed to read this today. 35 weeks pregnant and just gone no/low contact with my mother after years of abuse and being the scapegoat to my brothers golden child and I’ve been struggling so much with the guilt. My dad is similarly in denial / doesn’t think mums done anything bad. My one saving grace is my brother is finally de programming from years of hating me, and think i was awful and selfish, to seeing how I was victimised from childhood. Which helps but also hurts so much to finally hear I wasn’t imagining it.4
u/BaseHitToLeftSooner or later sometime is going to slap the hell out of that "Mother". (Not advocating violence, don't ban me, just predicting the future)4
u/summercloudsadnessOOP needs to put some physical distance between her and her family ASAP. It's difficult to enforce boundaries when your patent is your landlord. Once OOP will taste a life far away from them,she will automatically thirst for more freedom and less contact. Atleast do it for the kids. I have seen many families that suddenly flourish once they had to move away for employment reasons. Such a blessing in disguise.4
u/Legitimate_Book_5196She's giving her sisters way too much credit and it's going to bite her in the ass. I understand she can't see it after years of being treated poorly but they still are not treating her the way she deserves to be treated.4
u/Icy_Bowl509She really isn’t standing up for yourself at all. She keeps her hand in hoping for change that’s never coming. She has a beautiful family of her own. That should be her focus. Cut the mentally draining ppl out of her life.4
u/Hesitation-Marxshe is in CONSTANT pain All I can say is… good.3
u/BabserellaWTTake as old as time. What happens when the scapegoat decides they’ve had it and peace out? The abuser finds another target. Suddenly the golden kids care about the abuse, what a shock!3
u/Mattriculated"Except for the birthday dinners, my mom doesn't treat me or the kids differently." She says this after having listed at least two other ways she's treated different, and goes on to list three to five more...3
u/maywellflowerSuckiness of being December baby, I have similar situation as OOP where family made me pick between birthday or Christmas as present and/or party, but can never have both despite birthdaybeing weeks earlier. Now family is permanently pissed off at me because I go away on vacation for my birthday for like week or 2, so need nor way for them pull birthday or Christmas stupidity on me due to me taking that "choice" away. OOP's mother probably losing her mind while lashing at everyone remaining because OOP both took the choice away regarding December and showing that simply "Sorry" is not going cut it due not physically coming back during year over the last straw that broken camel's back AKA the trip. Now if OOP can finally do right by the kids and nor let them see grandma again - OOP will effectively cut off the supply of abuse of access to any children of OOP, that the only kids the mother will abuse going forward are sisters. Sucks, but better them than any children of OOP, including stepkid, at this point....3
u/Internal_Praline_658Dude, OP needs so much more therapy. Her shitty sisters need to bounce. They had to get verbally abused themselves to see it’s a problem. And no apology. Fuck the dad too. He’s still married to it and supporting it.3
u/TopAd7154OOP needs to bin the whole lot of them. What a disgusting bunch.3
u/TypicalManagement680This is a frustrating read. I could just shake OOP, my god. OOP admitted (and abides) her mother showing favoritism with her kids’ birthdays, does she not think her kids are not noticing that?! Before they his recent incident, OOP would’ve said her mother treated her kids great, the same mother showing birthday favoritism, a shared experience between OOP and her kids. Why would she even want her mother around as any sort of influence and role model to her kids?! OOP is still refusing to see things clearly and fully regarding her mother at ALL. Why does it have to take for her mother to be abusive towards the children for her to stop them from going over there, she knows her mother is abusive asf and really should’ve shut down any and all opportunities for her to be abusive towards her children.3
u/Wise_Relation_6949What a sad, mean woman. Fully NTA in the least. Shame on the family for never standing up to her because they don’t want to draw the fire.3
u/Boggers111What a shit family, her sisters still haven’t apologised. The dad is a spineless coward.3
u/ChandlerddDNA does not make a family. Find those who are kind, thoughtful and considerate. Cultivate friendships with friends and leave every single family member in the dust. I wish years of happiness for you, husband and children.!!3
u/Heavy-Macaron2004Ah, yeah that sounds like a middle child. Poor OOP.3
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4r/malaysiaExposing the torture that happens in Malaysian prisonsSpecial-Orchid-703813950%32782.5PRP knee treatment2026-03-07↗
commentercommentsentimentupvotes
u/Special-Orchid-7038Public proof <image>191
u/TheBotMadeThisI 100% will not survive prison.163
u/chooocothis is insane. serious violation of human rights. have you considered talking to western media about this? like BBC for example122
u/RGK777Damn bro. You're a stronger man than me. No way I'd survive this hell117
u/Independent-Ask5674Been waiting for ur post. Thanks for sharing104
u/SuitAffectionate6351OMG I would die on the first day inside there.64
u/LevelPowerful6816Based on your post, you went to the tawakal block too right? What is the reason you were sent there?63
u/BlueInNovemberHi. I used to visit Sg Buloh prison to treat the inmates. They have their own prison clinic but a team of specialists would sometimes go there. I volunteered each time to go with my boss and one other colleague. Man, depressing was an understatement. What OP wrote was definitely plausible although I would only get about 10% of the fact as the rest are being supressed by the prison guards/wardens, I'm sure. I was never left alone with the inmates but they were so out of it - like either high or traumatized or just too afraid to talk much to me. ALL of them want meds. ANY kind of meds. They would plead and beg. It was so hard to elicit genuine symptoms because they said yes to everything. Even if I just made up a pretend symptom. Except for the men on deathrow. They were brutally honest. The things they say... I remember to this very day. The inmates and staff I interacted with were very polite. The first time I was there, I expected something like Shawshank Redemption and the inmates like Hannibal Lecter lol. But it was more like a well-guarded old boarding school for adult men. After we were done for the day, the staff would take us to the dining hall for a meal. The staff dining hall. I have also been to the inmates dining hall but that's about the only place they let us see. The food was actually surprisingly good but I was the only one eating mostly to be polite. My colleagues were afraid the cook would spit in the food or worse. I have also treated inmates from other prisons but they would come to us instead of us going there. It was an experience I'd never forget, Penjara Sg Buloh. Thank you OP, for sharing your experience. I only saw what they wanted me to see but I know it was definitely darker than what I've been led to believe.60
u/Long-Desk9231Thank you so much for sharing. The fact that there are no politicians or ministers even care to tackle this serious issue is very upsetting. The whole Malaysian prison system needs to be revamped and revised. It's way long overdue. I figure someone like Syed Saddiq can try to at least change this evil, outdated and uncivilized prison system that has been a part of this country since forever. Human rights organizations in Malaysia should also tackle this issue and make it known that this is not okay. We're in 2026 and this kind of system should not be a part of this country any longer. And some Malaysians are surprised why we can't beat Singapore in terms of progression and development, this is one of the reasons why.47
u/mraz_syahI've experienced went to jail very long ago, i was in a club, and the police do the raid that night, that day i didn't feel want to go anywhere cause i have a bit fever, but my friend force me, so i took panadol and go to the club, and when the police raid happened, they randomly choose people and asked to go to toilet to take urine sample, and they do some test, and sadly, they detected some drugs in my urine (duh, i eat panadol). so sent to the jail, i really don't remember what happened cause i really want to forget it, but 1 thing that i really remember is, we give all our belongings to the officers. something i really remember is when the officers check my wallet, they're rm50 and rm20, they officers said, "ok kita ambil yg besar ye", being sad and confused what the hell its meaning, I just say yes, and the officers take out that rm50 and put it in the pocket , and he said, "nnti awak dpt makan nasi ayam sedap", in my head like whatever, i didn't have any appetite anywhere, we are in the hall, and asked to removed all our clothes in front of all people that do like marching, and do the squats few times, to check if they're any drug probably, and given the prison cloth and chang afterwards. and yes, i do get a big better meals, but didn't care, was put in a prison consist if i think around 10-20 people, sleep on hard wooden kind of big bed with all people, and have open toilet that everyone can see ur business, and limited water to wash it off, time in there is hard to know, just a small windows to know its morning or night, and next day i think we go to court and pledge guilty or not, i said I'm not guilty,and need works whatever I don't remember, and we being bailed by police, but given certain date, to come to police station to check our urines test (I'm clean). yeah i agreed what OP said that some local, they want to go to jail just to get something to eat or something, because in the jail, they're few people keep on going in and out, they said its like 5-10 times they in there, and they seem ok45
u/Kuro2712I knew it was bad, but damn this is downright horrible.41
u/soonersoupMan, this is so bad. I wouldn't even treat a stray cat that horrible41
u/FinalAppointment6221Noted. Tq op. One more reason to not get into jail. Malaysian police is like 50-50 chance if you meet them outside ( they stop you car for example) , you going to get summon or giv br*be. It is is a known knowledge.37
u/jenozsideTIL: Prison guards might be in the T20 category33
u/Bitches_Be_CrayfishMy god. Reading this makes me feel sick cause I know it’s true how corrupted and inhumane our justice system is. Cops are pigs.33
u/playgroundmxFuck, I can’t even finish reading the post. The way they treat people is horrible.31
u/JollyCandy5Do you know what happens in the female prisons? Are they relatively same as men’s?28
u/abacteriaunmanlyThanks bro really appreciate this post25
u/tophthemelonlorddsometimes i wonder do they have kids/families back home? how do they face them after a whole day of treating another human as subhuman? are their brain wired differently? do they hire only psychopaths?20
u/adam20101For the first time i dont see Malaysians have moral superiority complex in the comments lol20
u/TheSodaDudeI can’t believe this is real18
u/Special-Orchid-7038Now I'm gonna ask the real question, PMX and Najib experienced this first hand?15
u/heymemes8There are a bunch of sadists and sociopaths in the "justice" system, it's so fucked up man14
u/koolio92I know a lot of people will be like this is not okay and can't believe that this is happening but this is a result of our own society. The way we romanticize criminal punishment and see criminals as subhumans and justify their mistreatment - these are all indirectly our faults. Prison is for rehabilitation, not punishment. I know many of us see prisoners and think rapists, murderers but majority of prisoners are in prison not because of their own fault, some are just poor, some were unjustly criminalized, and many did not have a choice in the matter. Even if they committed a heinous crime, everyone deserves a second chance. Also, police brutality and corruption aren't new. It's always a thing, everywhere on Earth. ACAB applies to all police, including your uncle/dad who may have not been these monsters described in OP's post but they were well aware of corruption and said/did nothing.12
u/BennydckCucumberI hope you’re doing better OP, this is terrible. And abt the lack of reforms? Maybe it has smth to do with the generally conservative political outlook that this country has, imo better facilities/treatment etc for prisoners are usually found in more left-leaning countries.12
u/Vankomon888How about sodomize activity among inmates? Is it real like in Shawshank Redemption?12
u/interstellararabellaI wish your story would go viral. This is serious human right violation. We don’t even treat animals like this. It’s complete unacceptable10
u/charliekirks-holeDamn. Shit eater. That's one hell of a punishment 😭🤣😭🤣😭🤣10
u/jimmyisbrokeAre there women there? Are they being treated this way too?9
u/15yearsTitanShifterI dont get it, if things are actually this bad, why isn't there more public discussion about it? From my limited exposure to malaysia prison system, like sewing classes or talks given by the Imam. Is that just a front, or am I missing something? That’s actually terrifying cuz i really thought we had it better. No dignity given.8
u/Seekret_Asian_ManThat's it, I carry cyanide just in case.7
u/MrWiseFrogI wonder if the military is the same as the police. I’ve met couple of military dudes when i joined a camp when i was in high school, they were pretty harsh with the punishments, like we have to eat grass if you don’t march properly, and they were strict. But also sometimes they were chill, they joke around with us and don’t seem like the officers in OP’s story. But then again, I only saw the surface of it.7
u/rakkksaksaDrug case OP? Just curious.6
u/AifelseSannWow I just read thru... Such an insight, keep it going This is my country and I would like to learn more about it6
u/Glad-Ad8735You went through literal hell for this, I hope you’re doing much better OP.6
u/Pelanty21OP, someone who went to Sg Buloh had a similar expose a few years back on the lowyat.net forum. It's over 23 pages long and mostly ppl asking if he was raped. But his stories generally align with yours. lowyat forum5
u/assault_waifusI'm surprised by how many people here don't know that high-profile political prisoners receive different treatment.5
u/chooocojust curious about the racial / ethnical distribution in there - is it comparable to Malaysia's population? mostly Malay, then Chinese etc?5
u/[deleted]I really wish you can write a non-fiction book about our prison system. It can become an impetus for change if enough people read it.3
u/Wai-SeeWhat exactly happens to prisoner without any money? Like what happens to those who don’t smuggle contraband in, and just live on whatever provided by the prison?3
u/oncesagaciousBalls to you. I’d have been broken both mentally and physically had I been in your shoes.3
u/SensitiveBall4508The most moral of countries really. Thats why we can dictate what other people should do. But yeah. Thats all kinds of fucked up.3
u/Huge-Bed3245What happen when you went right on the scanner? I mean the other way besides tawakal block.2
u/[deleted]Najib is laughing2
u/bettabeatieHow were the prosecutors and court staff treating you?2
u/tyl7Since you said you stopped receiving money from your family, where did you get your habuk and abu to smuggle into the prison?2
u/bettabeatieWhat happens when inmates die in prison? Is the coroner called and lots of paperwork to do?2
u/Defiant_Let1377I wonder if some people have to experience conditions like this just for "possessing two packets of stolen Milo from a supermarket"?2
u/inzfireThat eating shit part...ngl could be reported to human rights activists or whatever... ngl murderer or sexual assaulters should eat shit ..but petty crimes doer shouldn't experience that imo2
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5r/BestofRedditorUpdatesAITAH for refusing to talk to my dad and brothers after the comment they made to...FunnyAnchor12313670%42282.5PRP knee treatment2026-03-14↗
commentercommentsentimentupvotes
u/OutOfAllTheAltsFor trigger warnings, you can replace "puzzling motivations" with "incest" and "sexual abuse"1791
u/tattoovampDad and brothers all think like rapists.1632
u/performancearsonistWell, I'll give OP credit. It definitely sounds like a 16 year old wrote it. It doesn't make any sense, but I believe a teenager could come up with this level of nonsense.1359
u/ebolashuffleThe comment about wearing a guy's shirt being him " marking his territory" sounds so stupid. Also, her dad destroyed most of her clothes, what the fuck was she supposed to be wearing?929
u/istaraSounds like dad was "stumbling in his walk with God".918
u/mmavcanuckIt’s amazing how many borus involve twins.502
u/imabigfillyWhy is no one talking about the fact that the mom is clearly in a lesbian polycule wherever she is and has essentially left the family but they can't say that because divorce is still taboo in some cultures?468
u/Quirky-Weird-4242In summary, incel dad raised a bunch of incel sons..356
u/41flavorsandthensomeThis really bothered me to the point that parts of my brain shut down. Not because of OOP, but because her dad and brothers are fucked up. I think her brother (was it Elijah?) getting in a fight after sexually harassing a woman pretty much summed it all up. The dad and bros didn't want OOP to get assaulted because of what she was wearing, which is total bullshit because rape is about power, not attraction/clothes/whatever.246
u/Elfich47So five men treating the "little girl" of the family as property. A story as old as time.222
u/fromofandfori hate everyone in this family for how hard they failed this girl. jesus fucking christ.213
u/Chaos-Pand4Oh no, I'm here too early. There are no comments here to tell me if this is worth a read or not.211
u/ShooHonkerThis K-drama has terrible writing.98
u/imaginesomethinwittyThis isn’t even interesting nonsense. If you need to make up a multipart story at least make it compelling.90
u/West-Kaleidoscope129From the very first comment about the skirt being short I knew dad and brothers were sexualising her! They just didn't want her in the skirt because they felt (like all predators) she was leading them on and they knew it was wrong for them to think and feel that way about her so blame her instead of their own perverted minds! Like father like sons!84
u/volkswagenorangeSo the big secret her father and brothers won't share with her is that they are all piece-of-shit misogynists and abusers. Got it. Meanwhile Mum has sacrificed her daughter's safety and left her with these disgusting abusers so she can have her own freedom. Got it. Cripes I hope OOP gets a decent job and never speaks to any of wastes of oxygen again.78
u/lfIwereaclownfishThis sounds like several Philippine families I know. It seems very common for the women especially to leave the home to work professional jobs overseas where the pay is good. Her mentioning that she got a lot of her cloths from fairs is also another give away. And then how the school is structured is also not how they do things in England. There's more clues but I just hope she cuts off her dad and brothers. Her mom needed someone else to step in and tell her to go be a mom smfh. Atleast she seems to have found a supportive, adoptive family. Honestly though, her mom being a traveling international lawyer sounds whole heartedly false. It's more likely she's a nurse, having multiple roommates fits that. In Japan that's how international nurses are houses, in groups and dorms.58
u/FairyGothMommyThis is one screwed up family53
u/Whatever-and-breatheSomething tell me that the manosphere may have something to do with it.47
u/Playful-Business7457This person does not speak English as a second language and is definitely only aware of the American school system through TV and books40
u/PastalindeandoThese men are not safe to be around. What could they do next to their sister/daugther? What kind of "punishment" Will they consider entitled to inflict her? Maybe together, since they were oh so sure they could control her as they please.28
u/thesilveringfoxmom’s name is Godot23
u/Terrible_Kiwi_776I'm getting a vibe that the mom's divorced friend is more of a romantic partner. After all, she wasn't at work  but still didn't want to come home to help her child. Plus, why lie about a 3rd roommate? Maybe because having 2 other roommates sounds less intimate than the reality of two ladies living together for fun. I'm also getting a vibe that dad is probably projecting his own infidelity feeling onto his daughter.  Hopefully everyone in that family will get some quality therapy. They need it.19
u/violueimo the fact that it's so convoluted actually makes it feel more true. it's not like the idea is so out there. a bunch of men deciding a girl's vagina is some family treasure that they all must guard, even to the detriment of the girl herself.19
u/Exotic-Day-1082Maybe I missed it but was this family of a different culture but living in the UK? Kind of got that vibe.15
u/oceanducielWhat the fuck is wrong with the men in this family7
u/Yutana45Let's say it fir what it is: she wasnt a sister or daughter to any man in her immediate family. The mom was tryna tip toe around it, but it was clear they were all sexually attracted to her in some sick capacity. What an awful set of men. I hope her mom inevitably divorced and just sends money for the youngest bc the oldest two are lost causes already.6
u/LightOfHekateAh yes, the visual representation of how patriarchal conditioning hurts even the men that benefit: tearing an entire family apart, sending the older men to the hospital due to stress, breeding sexual predators with anger issues and entitlement problems, breeding spineless men who claim to be leaders while lying on their backs and presenting their throats for other men, and traumatizing the women who are just trying to live their lives with autonomy. Literally everyone failed the OOP. Dad, all her brothers, even her mom. The only safe space was her friend’s family and I am so glad she had support outside of the hell she was enduring but gods, do I feel the indescribable rage of every woman for how this transpired. I get that the mom wasn’t expecting all of those kids but you can’t just leave them??? Does she not realize that because she refused to own the fact she got pregnant without planning for the unlikelihood of another set of twins, she is literally the reason this all happened to begin with? Considering the mom’s reaction to hearing all of that, I’m inclined to believe that had she stayed like a mature adult who understands she made a commitment by choosing to have kids, no matter how many, she would have immediately corrected the misogyny the moment it came out. Though I’d like to believe that it wouldn’t have even gotten to this point if she did stay (see why it’s her fault too?) Massive props to the friend’s family, genuinely. For her age, OOP handled this whole thing really well. Despite the intense emotions, she found ways to remain grounded and respected her own boundaries. That mom, sister, and her friend all deserve the best in life. It’s good to see the mom at least try now and thank that lovely divorced woman who talked sense into her (may she heal and find real, healthy love), but from the update itself, it seems like the mom is just… accepting everything and not actually trying to fix anything. The dad brought up therapy but like… idk maybe I’m expecting too much but it feels like she’s purposely dragging her feet, but I could just be cynical and I’m genuinely hoping I’m wrong. I can see why OP is keeping this marked as inconclusive too… this is one of those situations that will either resolve or blow up more, especially if they’re going to be trying to do better because that one brother is going to be the one that refuses and escalates. Until something happens to force him to confront what he’s become, he’s going to just keep spiraling and drowning in his own anger. I wouldn’t be surprised if that anger comes from the fact his mom essentially “abandoned” them for her freedom and he resents her for it. I’m just rooting for the OOP; the only sane person in that entire family. May she process and heal this trauma and continue to step into the strong woman it sounds like she’s becoming. Edited: wording/phrasing6
u/GroslomThe only English or American thing I can detect in this is the language itself.5
u/ThePenultimateRoloThere is no way OP is in top grade classes and grew up in the UK. Her writing is not native English, no matter if she got interested in American English5
u/spacebunsofsteelThe constant mentions of her stuffed animals in the middle of a dysfunctional family exploding made me tear up. She loves her stuffies and doesn’t understand motivations of her abusive dad and brothers. This post hints at her mom finding a way out - constant travel, parenting via text, just sends a check. What is she running to? What happened to the lover? Why is affair boy baby accepted, but affair girl baby is scapegoated and carefully controlled as she matures into a woman? Considering how many updates there are, I still have a million questions. I hope she finds a safe spot and thrives.5
u/fjmj1980Honestly my first hunch was mom was a lesbian and everyone knows except OOP and every male now thinks anything remotely feminine is a trigger.4
u/TheFilthyDILOK, being a cynical old woman, I'm going to say what OOP's father and brother are too embarrassed to say. Heterosexual males often get erections when they see women in attractive clothes. They may even be responding that way to OOP and are embarrassed about it. They don't want other men responding sexually to seeing OOP, even if she doesn't encourage it and doesn't even know it. They know they can't stop these other males, so they're applying pressure on the only person they can somewhat control -- OOP. It doesn't excuse the insane rampage where he tore up most of her clothes, though. I'm willing to bet that he tore up anything that he deemed "too revealing"-- too tight, too low-cut, too short in the skirt -- and left her with a few baggy sweatshirts and a few longer skirts or loose-fitting pants. (I had a miniskirt as a teen that barely covered my butt. Did I wear that when my father could see? Hell, no! 😂 Did my boyfriend (now husband) like it? Hell, yes!)4
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6r/nbaWhen Wilt Chamberlain Completely Ruptured His Patellar Tendon and Returned to NB...RespectingOpinions12470%13382.5PRP knee treatment2026-03-25↗
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u/Chessh2036I’m so glad you posted about this, because it’s absolutely insane. This injury can ruin a NBA career. Pretty much did ruin Victor Oladipo’s career. Dante Exum was never the same. Yet this freaking dude RECOVERED IN 4 MONTHS AND 11 DAYS. And this was in 1969. He was an absolute freak.1085
u/IntelligentAd5460pretty confident wilt has either the greatest media propaganda arm in history or he was a xman562
u/OThePlacesYouWillGo7’1 280+ pounds, playing the full game up and down the court in Converses? Wilt was insane336
u/actually-potatoWilt once had to exit a game after taking a nasty shot to the nards while going up for a dunk. In the locker room, the team physician diagnosed him with severe testicular torsion and said they had to rule him out. Wilt didn't say anything when he heard the bad news. He just looked the doctor in the eyes and reached down to jiggle his ballsack until his left nut untwisted itself. He rejoined the game after halftime and proceeded to put up the NBA's first and only quintuple double, which unfortunately was lost to time as blocks weren't tracked in that era233
u/JustAHorseWithNoNameThey say Wilt got shot 10 times point blank before a game, and still managed to score 50 points113
u/ejiggleAssuming the injury was actually a fully ruptured patellar tendon lol. Basically everything I read about Wilt I'm reasonably confident is propaganda68
u/CookingLikeChefOf all the wilt stories this might genuinely be the craziest and most impressive, people are impressed with tatum coming back early from an achilles tear but that injury might be worse and dude came back in just a few months.... and was productive? Actually criminal how this isn't talked about more if this is real62
u/kirito6521At this point I’ll even believe Wilt is DB Cooper. Just feed me the propaganda and conspiracy theories47
u/sssSnakebiteI believe in conspiracy theories I don’t believe in Wilt existing. He probably did, but I don’t think he did.28
u/texasphotogThat MF is not real.25
u/One-Masterpiece9838I’m surprised he hasn’t scored 200. Jesus Christ. This man was a demigod22
u/donkeyinparadiseWilt probably pissed that it took that long lol12
u/bikedork5000Wilt would be the most freaky athlete in the league if he was in it right now. 7'1", 250+, and ran a 10.9 400m in addition to all the strength, jumping etc. Dude had athleticism to spare.12
u/eugoogilizerComing back to average 22 pts and 4.5 ast on a hobbled leg is insane enough, but also 22 RPG? Holy crap man…8
u/SoNoHeadQuestionMarxFirst Shai now Moody is coming for a Wilt record?8
u/OyeCorazonWe are talking about HUMANS here. I refuse to believe Wilt was human, hes a beast7
u/nugentismycenterWilt Was not as only the strongest NBA player of all time but Arnold Swartzenegger said he was the strongest person he has ever met. Is Wilt Chamberlain HUMAN!? ● Strength Stories You Won't Believe - YouTube https://share.google/y40eHcy7q83aRv9zN6
u/redmostofitI mean yeah anyone can recover that quick after injuring their right patellar tendon. I’ve just ruptured my left and that’s way different…4
u/BigHomieReeseWilt got superpowers, can bang 10,000 women and recover from life altering injuries4
u/Smok3dSalmonPretty compelling argument that players back then weren’t as athletic. Perhaps the floor was lower, but the ceiling might be just as high as today’s. This is up there with Adrian Peterson’s ACL recovery.4
u/Puppetmaster858I mean to be fair yes wilt is an absolute freak but I doubt he was fully healthy, if he was around today I’m sure the team would’ve kept him out a good bit longer. Definitely absolutely insane regardless and he’s likely one of the greatest physical specimens in human history but I’m sure he rushed back from that and modern medicine/doctors would not have had him return that quickly3
u/Chuckieeee0Fucking insane2
u/RealPrinceJayThis is an injury that has ruined the careers of young players today with all the modern tech and medical advancements Wilt was 33 at a time when 33 was really old as dirt in pro sports, medicine was nowhere close to what it is today, physical therapy is nowhere close, general training is nowhere close, and he popped right back midseason and had some dominant showings… People try to categorize, understand, and downplay the things Wilt did, but in reality there’s a reason why only Wilt did them I’ve always said he’s the closest thing to Hercules in real life, and maybe our culture’s last folk hero. He’s almost a mythological figure, each story more insane than the next, and yet a good chunk of them are true2
u/EmergencyLavishness1Some people just heal a bit quicker than others. Now, I’ll say right here. I’m no wilt chamberlain. I’m white, short and currently fat. But a few years back, I broke my femur. A straight crack from the base, about 6 inches up. I’ve got 6 screws still in there holding it together. I was told, I’d be walking unassisted in 3 months. And rehab would start then. I had no job an needed money. So I opened a kitchen after 2 months. Still had the leg brace on limiting me to a 45• angle, using one crutch to get about. I was back doing 50-60 hours weeks on my feet after 2 months. After the first week, I went back to the docs and said I need the brace off, cos I can’t move right with it on. I need more mobility for work. They flat out told me they’ll take it off, but very strongly suggest I do not work. Not should I be on my feet for more than 30 mins at a time. Anyone that’s worked in a kitchen knows that’s not possible. But without this, I’m homeless and broke as fuck. So I got it done. It wasn’t perfect. Pretty far from it. But there’s seemingly no long lasting effects from my stupidity to get back and work. So it is possible to just ignore doctors orders, go about your daily life at 75% while it takes even longer to heal. Because you’re not doing the rehab and rest correctly. Sometimes it’s just about need. Sometimes it’s about want(like wilt wanting a championship), and sometimes it’s just straight up fucking STUPID like me in my case.2
u/Countryb0i2mWilt was taking a huge risk. You can’t out-train a ruptured tendon. They don’t get much blood flow, so they heal slowly far longer than four months no matter how hard you work or how athletic you are. So just being on the court was a huge risk, and that’s before even considering the physical limitations. It’s honestly amazing he ever played at all2
u/superrealaccount2Is there anything Wilt didn't do, in some way or another?2
u/penguin_torpedo47.3 minutes per game Lol that's ridiculous2
u/HOFredditorthis is the final nail in the coffin for all the Wilt doubters. Wilt would translate in any era. He was a freak more than Giannis or any other freaks we've seen.2
u/Justinian1228Are we sure Wilt wasn't two different people? These stories are just insane1
u/rocket_beerSo in those 4 months, did he increase his productivity?1
u/NittanyScoutLet's hope Moody has a similar recover window. Hope hes back and hooping soon, it sucks his good season ended on such a shitter1
u/MR_M33Pinteresting!1
u/MelonElbowsWilt really isn't human, is he?1
u/bmoneygetsbucksAbsolutely insane to hear. I tore mine my senior year of high school and and got surgery that July, I didn’t even get an officially practice in college in until after redshirting my whole freshman year and needing a two extra months into the summer practices.1
u/QNIKET8half these stories about wilt have gotta be fake i’m sorry-3
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7r/PetsMy dog has been giving me the silent treatment for four days because I took him ...Apprehensive-Tax769212230%15682.5PRP knee treatment2026-03-20↗
commentercommentsentimentupvotes
u/mjh8212My husband is usually the one who does vet visits I stay home. One of our cats has chronic sinusitis which comes with ear infections. Husband took him to the vet got his meds checked him out. He comes home and runs meowing at me about what my husband did he’ll avoid my husband and give me a lot of attention for a couple days. He’s more bonded to me anyway but you can tell after vet visits it’s personal.231
u/Constant_Purple8875lol, yes, mine pulls this when I travel without her. Which is understandable, but I am leaving her with grandma who she is very enthusiastic to stay with a day or two on a regular basis, but a week would get me “banned”. ONCE i travelled for 2 weeks and she was cold to me for 2 months. would pretend not to hear well or that our old tricks stopped working. Give him time and routine back. Gotta earn that trust :)147
u/CinderbunniMy dog ran away (to find me!) when I left him with grandpa when I went on vacation. He was missing for 3 days as the entire neighborhood went on a hunt to find him. When grandpa got him back, he was fed and ENTIRE whole foods roasted chicken and loved on big time. When we got back, this dog, who was bonded to me and would make me spoon him every night, slept on the other side of the couch, wouldn't cuddle, avoided eye contact and would turn his head away from me for 3 MONTHS until he got over the trauma, the hurt, the feeling of betrayal? I was gentle and loving and gave him all the treats. It took a lot of time, and i did have a few moments of tears, but at the 3.5 month mark, he went back to cuddling with me and we now spoon again every night. Your baby will forgive you. Give him time.110
u/AnitaLatteI had a dog that wouldn’t look at me all the way home from the vet. Just faced the door in the car. But 4 days is kind of a long time. You say he got all of his vaccinations at that appointment. Dogs, like people, can be tired, sore and achy after vaccinations. Their immune systems react over a period of days or weeks, and they can feel under the weather. I would gently do a body check where he was vaccinated to see if there are any swellings or feverish areas. A call or e-mail to the vet clinic would probably be a good idea as well. We had a dog that got an egg-sized swelling on her vaccination site every time she was vaccinated. It lasted about 3 weeks before it was finally gone. Our vet said it was an immune system reaction that the vaccination was doing it’s job, but he still would report it to the vaccine manufacturer so they would have that data.50
u/Ok_Sell5000The best thing you can do right now is give him space and stop trying so hard to win him back. Every time you go to him with extra treats or the good boy voice he is interpreting that as you admitting you did something wrong which reinforces his behavior. Let him come to you on his terms and when he does give him calm gentle attention withuot making a big deal out of it. Dogs pick up on our energy and the more you act guilty the more he will act like you should be. Stick to your normal routine like nothing happened and he will realize the drama is over and come back around. He is absolutely running a theater production but it only works if you keep buying a ticket.50
u/pyxus1Lay on the floor with him. Lay down with your head on the floor. Get as low as you can. Let him sniff around you, push his head against you, rub against you. Don't say anything. He will understand your apology.31
u/Serious-Telephone967This is so well written and very familiar. Poor biscuits! Four days does seem excessive though. I have a stubborn hound so I always get the silent treatment and she refuses to sleep in the same room as me but for 24 hours max. Did he get shots while he was there? Sometimes those can cause them to feel unwell.19
u/blithetorrentMy corgi/border collie did that for at least a week, exactly the same thing. Close by, but the contract had been broken. It was when I cleaned out his infected ears, clipped his nails, gave him a medicinal bath and brushed him out all in the same day. He HATED any kind of grooming or interference and clearly decided I hated him. It was honestly pretty depressing until he finally either forgot or forgave me. On the other hand, I think it might have been the reverse, ie, he may have thought I was punishing him and that we were no longer pals. It seemed to take forever for him to warm up to me again. Heartbreaking.15
u/Anam_LiathIt was a little scary for him, you went with him into the lion's den and brought him out. He escaped with his life because you were there to lead. He's being submissive and shy now. He's not mad, he's awed! Lie on your back on the floor and talk squeaky puppy talk like when he was a baby. Don't make eye contact just play with a toy of his or even a towel. Be silly like he's a puppy and toss really good treats but don't look at him. He'll come around. He's not mad. Just a little off kilter and awed. Also quietly take him for treats a couple times to help defuse the car. Mine go to the vet in pairs, one gets treated the other gets a non-confrontational visit to the office. With 3 dogs, that means 2/3 of their visits are no big deal and they are there for their buddy.12
u/kateinolyI started taking mine for friendly visits. We walk around, the receptionists and vet techs pet him and give him treats, I put him on the scale, then we leave. My vet recommended doing this to reduce his vet anxiety. He is no longer nervous going into the office.9
u/ConsiderThis_42My dog and I had a system of time outs for bad behavior. I put her in her kennel for 15 minutes when she was bad. Usually it was for chewing on the wrong things. When the oven timer went off, I let her out and gave her something more appropriate to chew on. Then all went back to normal. Eventually, she learned to do things like bring me her old chews when she needed a new one, so I knew it was time to replace one. We had to work out our differences just like housemates sometimes have to do. She gave me timeouts by turning her butt to me and refusing to acknowledge me. I learned to go to my rocker, sit in silence and take my 15 minutes of time out with humility. I got in trouble for things like trying to trim her toenails, walking to the mailbox without letting her escort me, and petting another dog before first paying attention to her. She was OK with her vet trimming her nails. He had better clippers, but after one bad incident she never let me clip her nails again even though I bought clippers just like his. Once was enough for her. When I had to leave another dog I had at my mom's so I could get to work when we had major flooding on the Missouri River, I learned to call home everyday and have mom put my dog on the phone. Mom said that she would cock her head to the phone to listen to me say familiar things. That kept me out of serious trouble for not coming home. She really just needed to know that I was OK and coming back. But she really gave the guy who was ferrying people across the flooded river to the bridge a piece of her mind because he wouldn't let her in his boat so she could come to me. He laughed about that for years at how she fussed at him for not letting her in the boat. He said if he would have had a life jacket that would have fit her, he might have relented, given her insistence. But I was not going to get in that boat to come to her. The Missouri is very dangerous when it floods and I was glad he stood his ground.8
u/Running_Amok_My dog a Boston Pug mix sat for 3 days with her back to me after a vet visit. She was so mad. She did not forgive easily6
u/Natural-Escape-3537“He accepted them with the dignity of a man tolerating a handshake from someone he has not yet decided to forgive.” This had me lol’ing. You are a writer.6
u/OldCapricornHope it’s not a reaction to a shot.6
u/LostMyZenOur older boy cried at his first vet appointment. The vet gave him a shot and left the room to get something. He wanted her to come back. He also broke his leg at 8 months old. When we went in for his first checkup, one week after major surgery, he did his best to drag us into the hospital, cast and all. He was thrilled to see his fans. His little brother is not nearly as outgoing, or forgiving. If I do something really traumatizing, like try a collar on him to check the size, he hides in his brother’s crate (his favorite place when he’s emotional) for hours, looking at me like I’ve broken his heart and betrayed his trust. It takes a sincere apology, cheese, and a good nap before he’ll talk to me again.5
u/Easy_Olive1942Trip to the vet is definitely a silent treatment worthy offense in our house too. I get told off, maybe silent treatment too, for not heading out on adventure/walks too many days in a row or abandoning them too long too many days in a row.4
u/kajeynSo... In 4 years this is the first time you've taken him to the vet?4
u/thatveronicavaughnnThe most challenging thing about this is if you have to take them when something is actually wrong and its scary!! I am lucky that my dogs absolutely LOVEEEEEE going to the vet even if there is some kind of sickness, procedure, urgent situation. So I guess would it be worth it to try to find a way to positively reinforce the vet visits while theyre happening? Not that you're eager for this silent treatment again.... I don't know, not a lawyer, just taking a shot in the dark on this.3
u/quantumsparqThat’s a pretty funny write up.3
u/Key_Scratch_4584My girl is different, she Loves going to the vets, absolutely loves it, as we turn down the road to get there her tail is helicoptering to it's fullest capability. When we get in i need her on a short leash to stop it sending everything onthe shelves everywhere. The small amount of treats she got the first time we went there has stuck in one of those braincells for nearly 7 years now. When we leave, I get the silent treatment for hours.3
u/toxiclightThankfully my dog usually goes back to normal after a day or so when she feels traumatized. By the vet, by me being out of town overnight (despite the fact that she still has my husband and youngest with her the entire time!) She's thankfully quick to forgive.3
u/mitzilaniMy ex made me take our dog to get fixed and then he would pick him up, making me the bad guy. “What have they done to you, boy?!”3
u/Dry-Peach-6327Yes. One of my cats, now 16 years old, is the master of punishment. When I adopted a second cat 4 years ago, he wouldn’t purr for a month. We’ve moved a few times in his life, and while he rolled with it when younger, now that he’s old he’s gotten cranky and will give me the silent treatment. Currently he is punishing me due to a temporary move we did two weeks ago back to my apartment (we were staying at family house to assist with their care for the last couple of years). He now spends most of the time under the bed, sulking. I know he is fine because I have cameras around the house. As soon as I leave or fall asleep he wanders around the house, eats drinks and uses litter normally. Sleeps on top of his cat tree. As soon as I come home, he goes back under the bed and sulks 😂 he also cuddles with me on the bed in the middle of the night while I sleep, and wakes me up in the morning for treats. He has just started greeting me when I come home, but then goes back under the bed. He also use to love brushing time, but now he refuses to let me brush him which is a little problematic as he has long hair and he’s old. I have spoken to his vet and we will try a gabapentin script. we’re moving into our new house in a month, so I’m sure this will just happen all over again. But I think the gabapentin will help him chill out a bit Oh and about the vet. He goes to the vet every 6 months or so for blood work due to his hyperthyroidism. For about a month after each vet visit, he hides when he hears me getting ready in the morning because he convinces himself that I’m getting ready to take him to the vet. He is actually a very smart cat lol, I could go on. Like you, I talk to my cat like he’s a human and explain everything that is happening. I talk to him about going to the vet before and after it happens. Sure he may not understand but I talk to him about it anyway. 😂 All of this makes me really sad, but eventually with time and space my cat comes around. I’m sure your dog will, as well. I am surprised to hear about this happening with a dog and with a retriever mix, too. He may just be exceptionally smart so he is taking everything more personally.3
u/LdyjamMy pup definitely does this silent treatment when I took him to the vet. We went to a new vet and they take him in the back for his shots, bloodwork and all the not fun stuff. Now when he's returned to me he's so happy to see me and away from the mean people he doesn't give me the attitude anymore. I'm sure your fur baby will come around soon.2
u/Ju5t4ddH2oHe is part Golden. They’re the most judgy of all the dogs! He’s got you reexamining everything you’ve done, lol. You’ve paid your dues, let him have his space & he’ll get over it. No more extra sympathy! Or it’ll just get worse w/ him. Good luck!2
u/Ok-Potential-863Sometimes my dog will pretend he’s mad at me because he wants me to give him extra attention and plead for his forgiveness.2
u/Skinnylatte2Omg, this is sad 😭😭😭 And then I read the last part. Goofball (but he's a Goldie 🤣)!2
u/Reasonable-Crab4291My dog put himself in his open kennel and wouldn’t come out until my husband came home.2
u/RigabearOh god this breaks my heart </3 Surely time will do the trick, but I wonder if ‘popping the bubble’ in a sense could help. Is there something that makes him ‘laugh’ or makes him act like a puppy? Some game he can’t resist that can help reconnect you, help bring your hearts back into the same frequency? Oh our sensitive pups <32
u/Lunar-opalDid you apologize with snuggles and treats?2
u/Love_Baking_in_COTell your dog that we all have to do things we don't like.2
u/mcmurrmlAnimals can't pretend. He is mad at you. Hopefully it will blow over soon. They aren't like people. An animal doesn't put on airs.2
u/Baby-Giraffe286I am not an animal person. I have previous trauma and wasnt a huge fan before that. My husband and kids love animals though, so I always do the vet stuff for them. I also changed all the bandages and stuff after surgeries and do all drop offs and pick ups for overnights. It doesnt bother me when they give me the cold shoulder for a few days. Honestly, though, mine are pretty forgiving. Usually it takes less than a week before they are all over me again. My dog had to have a toe amputated a few years ago. My husband only took him to one follow up and the dog was mad for days. All they did was check his wound and rebandage it. He pitched less of a fit when I literally took him to get all the stitches removed. I think he just knows I am a betrayer and forgives me anyway. Lol2
u/Confident_Action4915Can… I point out a simple thing in dog psychology? Dogs DO NOT EVER assign blame. There’s most likely a fear factor here, or a loss of trust for some reason. In most cases is brought about by trauma. Please be patient and on the lookout for anything that suggests the shutdown was warranted or that the dog has anxiety disorder or depression. Not necessarily- It could also just be shock, not to say there aren’t ways to work on both, I just personally don’t know what they are.2
u/Over-Marionberry-686When my little Shih Tzu Falcor was neutered, it took probably three maybe even four months before he would snuggle with me again if I sat down on the couch he would get up and go to the other couch. When we went for a walk he went to the edge of the leash and stayed there. He was pissed.2
u/GlowInTheDarkSpacesI’d have a heart to heart talk with him2
u/queendecaffeineI stopped letting my dog get on the couch since we were about to move and needed to start learning new rules. My mom drew a hard line: no dogs on the couch. Anyway, my dog left the couch, left the room, went out and laid in the coldest room in the house on the concrete floor next to her dog bed. She refused to face my direction or acknowledge me, she refused to eat, to go for a walk - just laid there limp at the end of the leash dragging. It lasted 12 hours and the transition from couch access to no couch access was pretty smooth after that. It was, apparently, the largest betrayal she had faced in her life. I've never gotten a reaction like that since.2
u/Analyst-EffectiveLol. Dogs are not humans. The dog forgot about it 5 minutes after you left the vet1
u/coloradocrime2My dog does this after going to the groomers but only for one day. I've found that all I can do is wait it out. Maybe make someone else take him next time.1
u/KizzieukBe matter of fact around them and they forget much sooner. The more you try to comfort and soothe the worse they get. of course he maybe feeling shit from the vaccines many humans do so I guess so do animals and its nothing to do with you, just they he doesn't feel good.1
u/unicorn_345My 14 year old little man dog goes in for shots and has gotten dental in the past. He is a bit grouch man for days after those. The older he gets the more he is just done with me and the world for a few days. I can’t even touch him day of once we get home. He screams bloody murder. And of course he also feels like crap from the shots so eating is sometimes off the table for a day or two, or often at least pushed to a minimum. Sometimes it takes a couple days and some pain meds to get him interested in more than holing up in his bed. Other times he has gotten up the next day and been ok. Age has been part of that.1
u/Wackel81My cat ran to his favorite hiding spot after the last vet visit and stayed there for a few hours. The loneliest hours of my life! Not even his favorite snacks got him out of there. But at least he forgave me later on, reluctantly at least. But I feel that deep down he knows that in merely 10 months I will  betray his trust again.1
u/CicadaSlight7603This is kind of normal for cats? Mine thinks I’m a fuckwit most days and doesn’t hesitate to make that clear. Even though I have done nothing but good things to him.1
u/weirwoodheartThis is a joke, right? Dogs don't 'give the silent treatment' like humans do. Biscuit is probably just a little bit tired from the stress of something he found a bit taxing.1
u/CartographerSea5923I dunno, man. But that was a great read.1
u/sundancer2788🤣 yes! Everyone of them.1
u/MessagefromAMy dog loves our vet, even after surgery and needles she would never be mad about going. The cat on the other hand is an emotional terrorist. We had to go for vaccinations and an ear check-up after I found some dirt and blood in it. Had to get her ear cleaned by both the vet and I. She will Not Look at me. That’s been the situation at home since two weeks now 😂1
u/AppropriateAmoeba406My Labrador had TPLO surgery and then crate rest for a month. She still isn’t allowed up on the bed. You think your dog is pissed? Let me just tell you.1
u/SufficientOpening218take him out for a pup cup1
u/amso2012Man can you please write a dog story book!! You write so well and I could totally visualize Biscuit with the behavior you just described. Please write a book, you have a gift!1
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8r/BestofRedditorUpdatesHe gave me a key to his house!!!! (5 year update)Awwndrei14070%8782.0PRP knee treatment2026-03-04↗
commentercommentsentimentupvotes
u/CapStar300In this cynical, terrible world, this was a good post to enjoy.754
u/Agent_K002I am very disappointed that her fear of pooping at her boyfriend's place was never mentioned again in later posts and never got resolved. Not cool, in my mind I have an image of a woman that hasn't pooped in years. lol Cute and beautiful posts.441
u/SalaudChaudThis is very sweet. Time to log off, eh?179
u/TheFreakyHeartwarming. However I can't help but think of the italians hearing her scream and saying: shit, another noisy american got engaged.113
u/Obvious-Lake3708This very sweet. Much better way to end the night then the pissing ex wedding56
u/FirebirdWriterI am crying from happiness on a few levels. Getting treatment for an ED is incredibly complicated and the support and love in all of this? It's beautiful. I hope for another update someday where they're healthy and happy and doing well.37
u/pinkkabuterimonLmao the fear of pooping at his house post is so, so real. I love how many green flags I'm seeing in these posts.34
u/awkwardsexpunMan, I knew I should've saved this one for last.10
u/bbusielloI’m happy for the “survived together during covid.” I remember my fiancé (now husband) and I were taking our first “lockdown” walk outside and came across a couple in an intense argument also while walking. This was week one. For many, it was a disaster.10
u/StopthinkingitsMeThis is such genuine love and happiness10
u/Silent_Ad_8672Not the poop knife suggestion 😂9
u/repocinWhat is this, a short and sweet five year tale of happiness with no drama? Did I click on the wrong sub? Man, this was refreshing to see. I hope they're both happy for the rest of time.9
u/UnhappyTemperature18This is *delightful!* And because I'm a nervous nelly, she needs to get that ring sized or it's going to slide off in a canal or something.7
u/Fire_or_water_kaiI was holding my breath the whole time, worried that something awful would happen. Such a sweet palate cleanser.7
u/exit322This is slightly better than the breast milk story.6
u/bakanisanA 5-year update and we didn't even get a mood spoiler?!?! How am I supposed to brace for it huh??? /s5
u/ben-hur-huraaand I am going to sleep after this with a warm heart lol5
u/Enough-Ad-3111Nothing but love in this post thread. Congrats to them.4
u/mewmeulini'm crying happy tears over this one. love where they're both obviously enamored with one another is the best kind of love 🩶 i hope OOP's ED recovery is going well, and i'm wishing them both the absolute best4
u/Eastern_Mark_7479That's enough internet for today UwU3
u/TariqKhalafThis whole thread felt like watching a relationship grow in real time. The update about him walking her into treatment honestly made me tear up a little.3
u/No_Pattern_2190Borrrrrriiiiiiiing (Kidding)2
u/stressedbrownieCrying for strangers on the internet AGAIN2
u/CharlotteLucasOPIf you clog his toilet and he balks, it wasn't meant to be.2
u/SparkpulseAnyone else here looking at her hands in the ring photos thinking "those don't look too skinny, they look like a healthy weight" and being proud of her for that, too, when the part right before was about anorexia treatment?2
u/spherical-chickenIn what world is outlet shopping and burgers an "elaborate" day trip?2
u/Double_Surround6140Feelings I will never feel since I had to be born with awful genetics that gave me vision issues. Hope reincarnation exists for a reroll.2
u/people_pleaser2481loved reading this. heart is happy1
u/Olibro64Nice vignettes of life.1
u/Bright_Chef_1926I am so happy for oop! Please keep updating us.1
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9r/DeadlockTheGameDeadlock update for 3/21/26wickedplayer4948130%91981.6regenerative medicine2026-03-21↗
commentercommentsentimentupvotes
u/SilverFan3702somehow green abrams returned783
u/secretwepSHIV GOT KNEE SURGERY679
u/kudlesYoshi HATES ability range 🤣645
u/Twippin-The-CattoYoshi when it's time to massively change the game again on a random Saturday afternoon. (We love to see it.)583
u/nottheusernameiwantMirage: Fire Scarabs now reduces enemy damage output by 20% (and +15% in T3) 1vs1 king394
u/kudlesKelvin ice path gonna be oppressive af 🤣🤣 with transcendent cooldown and t2 you can have perma ice path pretty much388
u/xippy_boivictor found dead on the streets293
u/A_HippieBuffing Abrams is hilarious work269
u/DJKirby05Graves’ tier 3 grasping hands spawns ghouls now? That’s kinda crazy ngl244
u/Ill_Celebration2902Shiv: Bloodletting is now affected by healing modifiers this means anti-heal like healbane works against bloodletting now right?228
u/tyvsaurVyper remains the epitome of balance203
u/TheTaffyManFeel a little crazy seeing Abrams buffs199
u/MTG_RelevantCardMcGinnis becoming more turret oriented and less ult-oriented This is, stylistically at least, a direction I’m down with.190
u/Glebobas-BarabasI hope this doesn't turn into a DOTA situation where every single character has a health bar of a reasonably sized elephant by minute 20173
u/Skippy-the-meme-LordYEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESSSSS!!! GREENS ARE PERCENT AGAIN!!! HYPER TANK HERE I COME!!!!163
u/LuvatrisCeleste buff is diabolical Falloff nerf is not that huge for these buffs161
u/Physical-Scratch-856breaking news: victor's kneecaps completely obliterated in 4k 240fps160
u/mizerakliddoorman range is nerfed, its joever156
u/DarkWolfPLThat Silver buff155
u/slimslyOh mo, that’s gonna krill him133
u/ExcelIsSuckGRAVES BUFFS YIPPPPEE. That wall buff is so cool... and as an fyi to all graves mains the ghouls summoned by the wall get the buffs of the tier 4 upgrades, so gravestone wall max build?125
u/BT--7275Abrams cant be B tier for more than two weeks I guess. Also, Celeste buff?!100
u/ARClegend_18My ability range stacking builds noooooo96
u/BahBaloonIt also bugged mid boss that can't be damaged..91
u/Doot-and-FuryMina's glide animation now has red haze coming out of her umbrella86
u/RaknargBro they desperately want us to play melee apollo holy. With duration extender and max riposte you can reliably hit 2 heavy melees now by the way.83
u/UllrCtrlThey treat Celeste and Silver like make a wish kids lol83
u/The-Weather-ReportValve needs to sit down and have a good, hard think about what they want Mirage to do. The only thing they're sure about Mirage right now is that they still want him to be really bad except for the 10 to 15 minute mark of a game where he's okay against incompetent players and bad against competent players. Djinn's Mark scaling being reduced along with doing no gun damage means he's not a duelist. However, his boon scaling for HP is just average, so he's not really a tank either. Valve, after all this time, still don't know if they want him to be a duelist or a tank, and have settled on him doing neither. His time to kill was already the longest in the game when things went well. He'll still be an okay "on-hit" guy, but if the ceiling is that low, I think he could realistically hit sub-40% WR once data comes in. Very usual of Valve to experiment with every option except the very obvious one.81
u/The-Invalid-OneBallistic + Expansion nerfs, plus punch nerfed wonder how the goo man will be this patch68
u/CarelessCourierIvy: Air Drop cooldown increased from 65s to 85s Ivy: Air Drop cooldown is reduced by 25% when used on allies Fucking catch me picking you up and dropping you immediately after just to get that sweet sweet cooldown reduction49
u/CoolVibraniumadding lifesteal effectiveness as a stat just to nerf vic is diabolical49
u/PAIN_PLUS_SUFFERINGNow instead of being functionally useless in teamfights for 30 minutes, Victor can instead be useless the whole game. Thank you Yoshi49
u/Drag0n122No Venator changes? Interesting47
u/chuck-me-papadamn that calico 2 scaling42
u/The-Invalid-OneDynamo: Quantum Entanglement T3 now also replenishes 1 charge for charged abilities (half effect on allies) does this just mean it halves the cd?41
u/firemembleThe Seraphim Wings change for brawl is fucking crazy. If you don't roll a gun carry on your team and they have a gun carry with this you instantly lose and there is nothing you can do about it. Even with a gun carry to shoot them in the air 60% is just stupid and you can pretty much stay in the air forever now. Genuinely who thought this item needed buffs.39
u/RodrubyAbrams buff, Celeste buff 😭 Victor seemed to be hit hard, no 1v6 diving and surviving, on one hand it's fair, on other hand - what does he do now? Nerf Mo ult, reasonable Percent health means squishies still squishy and tanks are tankier, we'll see how it changes meta33
u/RheasGarden<image> FINALLY LONG DISTANCE BITES!32
u/PastPalpitationCryWow they just killed Victor with that lifesteal change.31
u/moonjelliessmid boss bugged gyulp29
u/avayevvnonWhat do you mean they gave mcg's gun and turrets compensation buffs for her ult scaling lmao26
u/TParadox90GRAVES BUFFS TY YOSHI25
u/sirmsthey buffed the legendaries lmao hell yes20
u/CoralWarriorKinetic Pulse is longer and thicker 👀15
u/dankeykanngDialing back some of the cooldowns is a much needed change12
u/red--deadThis is a pretty light nerf to mcginnis ultimate right? Depends really on how hard the ability range item nerfs are moreso I guess11
u/Accursed_flame1A little confused by the stomp changes for Dynamo, if the goal of the previous big patch was to backload the ability for T3, they did it just fine. T0-2 stomp currently feels pretty awful to use in lane, so even less damage on its tiny range just, strikes me as odd. Its fine, I'm just surprised Yoshi feels the prior changes werent far enough.9
u/Doot-and-FuryThe Fall And Rise of Shiv's Mobility8
u/OxGeNiDCan anyone explain to me how shivs bloodletting was nerfed like im mentally challenged because i actually might be7
u/Winter0808can confirm after a game, mcginnis ult build is still broken6
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
10r/hairgrowthProgress Timeline of My Hair Transplant - 1 Yearcatsonkeyboardss13690%7381.5PRP knee treatment2026-03-06↗
commentercommentsentimentupvotes
u/Complex_Grand236Looks great! Thank you for sharing.19
u/Impossible_pothosOh cool I am happy for you!! I don’t know why I always associated this procedure with men, that’s true us ladies can do it as well ♥️9
u/kleverklWonderful8
u/Pretend_Agency_7300Thank you for sharing as I believe you will help many. Your results are truly remarkable!5
u/deleteshiftreturnThat’s awesome. We can’t really see the hairline now to compare since your hairs not pulled back, but wow this is great.3
u/charlirobeyBeautiful results, thank you for sharing! If you don’t mind me asking, does your hair seem considerably thinner at the back now? I’d love to have this done but I fear I don’t have much to spare at the back 😭3
u/czringWhat was your hair loss diagnosis?2
u/Difficult_Humor_9799Thank you so much for sharing. And you look amazing🫶. Great result.❤️2
u/MarsupialPrimary8128Wow. Well done. The patience!2
u/Evil_Yeti_a) What do you have to do for continued maintenance? Any topicals/treatments? b) What's the plan for when/if the original hairline recedes? Or are you doing anything to prevent that?1
u/cowgirlfr0mhellLooks lovely! 🥰1
u/christinagb123Do you have a straight on picture from before your transplant? I have thought of this procedure from time to time. It looks great.1
u/SpareControl4290Incredible results! You must be so pleased!! Can i ask what you paid for that operation?1
u/MisericordeeWas it painful?1
u/sdbabygirl97i’m interested in this but im curious what you did during the awkward growing in phase? especially bc theres a huge shave at the back and the new hairline is coming in?1
u/GirlPhoenixRisingThe area they take the grafts from doesn’t ever grow back so you’re telling me you sacrificed all that back head area? Had you tried medicine first? Glad you are happy with it!1
u/WorkLifeScienceCongratulations, this is really amazing, you look so happy! I am not usually a fan of esthetic surgery, but I totally understand that in some cases it can be very helpful and improve your life quality and confidence!1
u/WarmWhiteLightsOh wow! I never thought hair transplants were an option for women, I only ever thought they were for men and for some reason it wouldn't work for us. You got great results. It looks so good!1
u/KaPowBamAmazing progress!1
u/LankyGiraffe9891Wow! That is amazing! I am a woman with a larger forehead and I’ve always wondered about the process in doing this! Thank you for sharing!! One question if you don’t mind answering, from the first photo which I’m guessing is right before the procedure, to the last picture - how much time has passed?1
u/sarakana10Aww never been more happy for a stranger you look wonderful ❤️1
u/444ARLHow much was the overall cost? This is something I’ve been seriously considering. But haven’t heard/read results that didn’t seem like paid advertisements. Thank you for your vulnerability1
u/NorthFront5725Wow1
u/EmphasisAcceptable28Looks amazing! Congrats! Do you mind sharing if it’s the same texture as the original hair? Also, the transplanted area should be growing back ?1
u/Plastic_Sun_6789Amazing as I already mentioned! But can you pls share the doctors name?1
u/Fubsy41Science is AWESOME, like genuinely couldn’t be more fascinating lol. It’s looking great!1
u/Own-Statement-9570Wooooow.. congrats!!! It's so amazing. How much does it cost?1
u/AutoModeratorFeel free to report any comment that is disrespectful or breaks the rules, we do care and will make sure to shave them off. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/Flaky-Poem-7725Wowow beautiful!! Good for you and thanks for sharing 😊
u/witchy-kitty-mewBeautiful!!!
u/No_Event3010Did you try spironolactone before going for the hair transplant ?
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
11r/PerimenopauseI went to a dermatologist about perimenopausal hair loss. Here’s what he said:Ok-Zucchini-55146660%16080.7PRP knee treatment2026-03-04↗
commentercommentsentimentupvotes
u/memeblanketCome join us over in r/femalehairloss162
u/Prudent_Ring_799I would check iron/ferritin and thyroid before spending on the light helmet. I found a lot of posts here recommending Mega Foods blood builder iron supp. I bought it before I foubd a dr willing to prescribe HRT because Im vegetarian and so many women were saying it is a game changer. I agree 100%. I will NEVER not buy this!!! I have only been on HRT 3 weeks but my follow up is this week. Dr told me thyroid tends to go downhill at the same time peri symptoms appear so had me do labs at initial appt. I looked at my results online, T3, T4 are fine but TSH was way off. Researched thyroids and there’s a good subreddit too. I am pretty sure he’s going to put me on levo and a major symptom of high TSH is hair loss. I feel like the iron supp helped some w hair shedding/new hair growth (wispy baby hairs growing! small win, but Ill take it!), HRT helped a LOT more w shedding, and hoping thyroid will lock it down. Not saying Tron mask wont work, bc tbh Id have tried it already if not so pricey!! Lol!! Regardless of what you try or don’t, HUGS to you! I have spend so many hours online trying to fix my hair. Im Italian/Greek. We usually are TOO hairy so this was just devastating having hair fall out in clumps for over a year.120
u/CopperGoldCrimsonWigs aren't your only option! Look into beaded toppers, flip over method sew-ins from Black stylists. You can learn to do the toppers yourself if you get a custom unit made. Check out Sofia Hair Health on TikTok for protocols that are DHT blocking (she has androgenic alopecia), shampoo with ketoconazole, micro needling, etc can make meaningful differences.36
u/rainbowtruthfairyWhich med did the derm prescribe for the torso rash? Antifungals (orally) did not work in the slightest to clear mine up. In my case, the rash in the umbilical region began at least 1.5 years prior to the nights sweats and hot flashes. It is behaving like some sort of autoimmune condition, and has been getting worse since May or June of 2024. The only thing that ever helps, is extended, strict water fasting. But thus far, nothing clears it up completely. I think 40 days would probably heal it (from the inside out), but the longest (of many) WF I have done so far, is 25 or 26 days. As for the scalp issues, the number ONE best thing to use is apple cider vinegar (ACV). It is amazing. I use it at least once a week, prior to a shower: saturating the hair and scalp using a glass spray bottle, massaging the ACV in very thoroughly. I have used ACV for years. It TOTALLY clears up the scalp, and makes the hair ridiculously soft as well (which is why so many people use it as a conditioner). A lot of people dilute it: 50/50, ACV and filtered water. I generally use 100% ACV. It is great for skin blemishes as well. You can even leave it on the scalp/hair for an hour if you want, which is super clarifying. These days, I tend to hop in the shower, soak my head with the vinegar, and massage it in. Then I go about my cleaning routine, and save the hair/scalp for last (the opposite of what I usually do). Some people (self included) use ACV as a conditioner; but when I use it as a first step like this, I never need it a second time after lathering my head with a bar of soap. Literally baby soft hair is the result. I miss my hair as well. It used to be so beautiful. It was “my thing.” My one thing. But it started thinning out after I had my son at age 22. By the time menopause started at age 45/46, it was really thin (especially through the crown and at the very back of the head). I actually began completely shaving my head (pretty often: every 4-6 months), back in 2023, right after my brother died. The first time was on his birthday, in his honor. After that…all sorts of reasons. An exercise in self-love, in many ways. And a solid “F you!” thrown in there as well. When it is shaved, it is SO MUCH EASIER to stay clean - just in general. It (((feels))) way better than it looks (imo). It does feel great. I always hated short hair on me. But I also cannot have back what has been lost (so much more than hair at this point). But having gone ‘all the way’ like that (“Go big, or go home!”), sort of broke something open from within me, in a lot of ways. The work is still being done, nearly three years later. Now I am ramping things up with some supplementation improvements: methylene blue, creatine, and copper, in addition to my other staple supps. We shall see what happens.30
u/ReflectionOk2553I have been using a red light helmet for years. Not game enough to stop lol Hair loss is still progressing. It really is cyclical for me. Worse in summer and autumn and then starts to fill in more. Hrt in the last year did seem to make it better but my usual fall has been worse than ever before. I take photos every couple of months to compare.29
u/phootosellThanks and hugs! In the same boat. I wonder why I used to obsess about a few extra pounds or the shape of my nose or other silly things. Mow I feel have actual problems with hair loss.19
u/MissTiffany12This was exactly my issue! The androgen dominance was causing lots of acne and hair loss, among other things. Supplementing with a low dose of estrogen and continuous nightly progesterone has helped to improve it some. The shed has slowed down finally and my skin is much clearer.18
u/IlluminimalAre you not eligible for HRT? Since I started in November the density in new hair growth is hilarious, I have this constant halo of baby hairs, except they're getting to like four inches long now.14
u/TheUltimateFixerReally appreciate all the info you shared — thank you!11
u/KayNopeNopeThank you fore sharing all of this information I really appreciate it.10
u/Former-SeahI have POTS and I tolerate spiro. Totally contraindicated of course (isn’t everything?!) but I felt at about 70% for a couple of weeks. A couple more dizzy spells than usual but after week 3/4 I was back to normal. Saying this I am usually pretty mild symptomatically. I take fludro and I have had POTS for 10 years. But don’t take this as advocating as I’m not sure what would set you back. Just giving my experience.9
u/blue19255thanks for posting! I have an appointment this month.7
u/Meowmixx22What about fineasteride?  Derm said this is what grows hair.5
u/Away-Heron8167For what it’s worth I was deficient in Zinc and since supplementing my hair has been thick again!5
u/that_awkward_chickI have been losing my already fine/thin hair since my 30s and nothing ever helped it. Eventually I did look into wigs and toppers and there are so many great, natural looking options out there! Plus, it has been much more convenient being able to wash and style the wig before I need to use it and the day of I can just put it on and go. I even usually just bring one when I travel for a week…it usually keeps the curls for a few days and then I put it in updos or ponytails for the latter half. And no one can tell! If anyone compliments my hair, I am to the point now that I just tell them it’s a wig and they are very surprised. Some places I have purchased my wigs/toppers from that use natural hair: https://www.highlinewigs.com https://www.wigsbytiffani.com https://madisonwigsboutique.com And there are a ton of accounts on social media that post about hair loss and wearing wigs/toppers. More people wear some type of “fake” hair than you think!5
u/FightswithcrowsFor whoever is interested, I found this really comprehensive link on symptoms, tests, and treatment options for AGA https://australianprescriber.tg.org.au/articles/male-and-female-pattern-hair-loss.html5
u/huntergirlnc21Same boat here! I’ve been losing for about 10 years now without much relief from anything I’ve tried. I am on oral minoxidil which hasn’t helped, as well as HRT, but I try to accept it as much as my vain self can, lol. My grandmother was practically bald and I have aunts and cousins with significant loss too. I did wigs for a bit (mostly just too hot for me), done the super short cuts, but recently invested in a human hair topper. It is a game changer! It’s light enough that I don’t get super sweaty and is the same color as my hair, just with added highlights. My mom did not realize it wasn’t my own hair the first time she saw it. Might be something to look into!4
u/NeedleworkerCivil534If you have not tried pumpkin seed oil caplets with saw palmetto, please read up on them. I had been losing my hair for a year, and three weeks after starting these caplets it stopped falling out and has not started back. It looks so much better. I use the microingredients brand from Amazon.4
u/becaaaaahThere are DHT blocking supplements. Nutrifol makes one4
u/GivethemRachellI’m at the point where I just want to save up for a wig topper. Shit if I had the money I’d do a hair transplant. Plenty of follicles on the back of my head but a barren wasteland at the top. This is not my idea of business in the front and party in the back lol.3
u/Good_Connection_547My Canadian friend who lives in Mexico got what they call a hair transplant - but it’s really a rearrangement of their scalp. They basically peel your scalp off and put the areas that aren’t affected by female pattern baldness in the front, and the thinner parts in the back. She had to shave her head, but she’s got a beautiful, full pixie cut and she looks amazing.3
u/soleiles1Have you tried Nirozal shampoo 2-3 times a week for the fungal issues?3
u/Dear_Cut4843Most dermatologists just treat the surface issue and forget the hormonal root. You really need to see an endocrinologist or a specialist who understands the hormone shift. Spironolactone worked for me when nothing else did.3
u/trishia42I'm curious to hear about women who started experiencing hair loss when they quite the pill (high androgen index pills) and whether HRT worked positively or negatively for them and hair loss... I lost a lot of hair density when I quit the pill initially many, many years ago. Then it sort of stabilized but then once perimenopause started, I started gradually losing more (dermatologist said AA), so I'm worried of rocking the boat once again but it would be nice if it would help too because yeah, hair loss is sort of devastating on top of everything else : (.3
u/IslandsandwillowsI’ve heard good things about PRP there. It takes multiple sessions but I think people have good results.3
u/Ok-Zucchini-5514[deleted]2
u/lapalmerado you mind sharing what kind of situation you had with the minoxidil? allergic reaction?2
u/Oakleydokley_JrI’m going through the same thing. :( hang in there.2
u/Lightstorm16I feel your pain - perimenopause is the absolute worst!!! I have had many people recommend the Vortex Wand to me butI have yet to pull the trigger on it (https://vortexhaircare.com/products/new-wand). But I have heard really great things about it as it provides a high-frequency treatment to stimulate your hair follicles.2
u/FilteredFocusAre you on HRT? If not you should strongly consider it. There are ways to control the DHT conversion so you don’t have this happening, such as saw palmetto. The dermatologist medications for the hair loss are only treating the symptom of a hormone imbalance. Once that root cause is addressed the hair loss will resolve itself.2
u/Thelastunicorn80ketoconazole shampoos can be helpful for some. One of the effects of ketoconazole is inhibition of the conversion to DHT which lowers the inflammation, sebum, acne and hair loss. It could be worth a try2
u/Fine-Grapefruit7177HRT helped me a lot. Check it out ferritin and thyroid function. Criscina hair loss treatment ampules is also great. Hair loss stops and new hair grows.2
u/monimorMy gyn recommended Saw Palmetto 500mg. She said that it blocks the dht in the follicles (or something like that) and helps with hairloss2
u/Sweet_Passenger_494I have the tron helmet the company sent it to me but I haven’t been consistent so I promise I’ll start and I’ll share my results. It’s just such a demoralizing thing my huge bald patch when a thick pony tail use to be my favorite style2
u/raw2082I had a similar rash between my boobs and I finally got it to go away when I started taking medication for my mild insulin resistance. I really not sure if it’s from peri or going through cancer 7 years ago because the weight gain issues started shortly after I finished treatment and is a known issue from chemo. Anyway my rash after battling it for 4 years has finally gone away and I quickly dropped the weight without changing anything. I already eat healthy and exercise regularly but managed to gain 30 lbs after treatment. My sister is struggling with her weight after she’s turned 40 but she eats a lot more carbs and sugar than I did. That’s why I question if mine is also related to peri.2
u/OkLie5597I’m with you bc my hair is thinning and it’s hard!2
u/PrinnykinI used to have beautiful hair until I went on HRT and it all started to fall out. So now I’m back on Yaz and I’ve stopped shedding. It’s worth a try if anyone wants to try birth control.2
u/O_W_LivWhat did he recommend for the fungus?  Dandruff shampoo?1
u/Future_Literature_70How interesting! I have the same issue, and I also have POTS. Tried Minoxidil but had a horrible itchy reaction all over my body and a massive headache for 2 days. Never again. I have a Hairmax hairband, which I've been using for a couple of years. But I think the most helpful thing for me has been increasing my iron levels (good hair growth apparently starts with ferritin levels of 60-100; I was at 30!), massaging my scalp (sometimes with rosemary water) and going on HRT. I also use Alpecin caffeine shampoo, which I like. It's all certainly better than it was, but still thin. I have a short haircut anyway, and I'll have to stick to it. I've decided to try a hair topper if things should get worse in future. But do please report back to let us know how the Revian light helmet goes for you. Not sure I'd really recommend the Hairmax; it was very expensive and I'm not sure how much it really helped (vs HRT/iron).1
u/FearlessExtreme1705Ketaconazole shampoo. I dont have any yeast or fungal issues and I still use it to block dht if my hair becomes super oily. Win win.1
u/Superb_Case7478I know you said you checked your ferritin, but be sure it’s above 50, not just “normal” range on labs. My dermatologist told me 20 was normal and it wasn’t . As soon as my iron got above 100 via infusion, my hair shedding stopped and started growing. I also have POTS, fwiw.1
u/BagGroundbreaking186Can you take oral minoxidil with spiro perhaps? I’m considering this combo. I’ve had pretty considerable hair loss since starting testosterone, so I’m hoping this works. I can’t believe how self conscious I’m feeling.1
u/Puzzleheaded_Lab4913Try saw palmetto- pumpkin seed as a supplement. If you can’t use minoxidil the Ordinary Hair Peptide Serum. I use that and minoxidil. I also use Nizoral for the scalp and the L’Oréal hair density booster line of products. It’s been helping me a lot1
u/Typical-Face2394A lot of women do well on Nutrifol1
u/FrostingConsistent39I use fibers in my hair. I’m balding on top (thanks Dad lol). And no one can tell.1
u/Alternative-Pea-4710A bit off subject, but as a menopausal woman, going to the doctor rarely makes for a good day. I was just told that I have “Severe Vaginal Atrophy.” So that’s great.1
u/Immediate_Anything_4Ghk Cu peptide injections and Omi gummy peptides1
u/Difficult_Affect_452What about oral minoxidil?1
u/sucodelimao802You aren’t alone! Mine started at 35 and was made worse my anemia. I use a compounded Spironolactone/minoxidil topical mix everyday and while I don’t have the hair I used to have, I still have hair. It sucks but I’m thankful for the hair I do still have. 🫂1
u/Tiny-Meringue4333I have a friend who has done the micro needling and PRP with amazing results.1
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
12r/Epstein"Canada's Epstein Peter Nygard" & Steve Powers on Stem Cell Technology (SCNT) | ...WelcomeWindsorCastle6290%8580.0stem cell therapy2026-03-05↗
commentercommentsentimentupvotes
u/Honest_Yesterday4435So basically they want to take the traits of black women and give them to white women. This instead of just fucking a black woman because they want to avoid the "black" parts. This feels pretty overtly racist right to their faces. "We don't want you, we want your ass on a white woman."negative204
u/Desperate-Pause6422It’s eugenics. Acid-fashism.negative111
u/shhhImasleepAh yes. Peter Nygard. He also liked to have girls “stool in his mouth.”negative85
u/wheresmystache3It seems like they didn't know eachother, but I did search the files and Epstein says he didn't know him when one of his friends asked. Later on, JE was trying to sell one of his planes and Nygard sent an offer, but JE didn't take it. One of JE's secretaries mentions that Nygard was interested in buying the plane's interior. JE and Nygard had VERY similar hobbies with sexual abuse on islands (Nygard had Bahamas) and obsession with genetics and producing offspring with their DNA. Nygard's obsession was with black women and believes their DNA to be superior. He bought placentas of the women he impregnated (one victim says he offered her 30k for her placenta!!) and had his team of scientists extract stem cells from them for him to inject into himself. Crazy how these two really didn't cross paths, just barely.negative42
u/Strawb_shakeFucking Crypt Keeper over herenegative31
u/[deleted]I’d rather not come across this tonight and ruin my night. They are talking about women as some sort of specimen to use for their projects. He says if they have abortion it’s even valuable as they can use it. This is utterly sick and disgusting. And they record this heinous conversation? What’s wrong with people…negative30
u/OverAmount5551Proof of another franchise in the same sketchy business? ?negative22
u/Chemical-Lab8446This is one of the most disturbing conversations I've seen in the internet in general, and that says a lot.negative22
u/Sacred_SilencioI’m so disgusted. $100 for their egg? This is modern slavery. Bet these white men will force these women to also raise these children without compensation. ?negative12
u/[deleted]What. The. Actual. Fuck. Females are not fucking cattlenegative11
u/silhouette_orchestraThis guy lived up the street from me.. He always had parties with a particular interest in black women. He let several live in the apartment building behind his home.neutral10
u/Financial-Newt2291Didn’t the Nazi’s do these types of experiments.negative8
u/Level_Worry_6418WTFnegative7
u/FewHotel5733Notice they mention about using and consuming everything, yet tip toe around mentioning the actual Baby.negative7
u/LifeAsNixThis is what Epstein was allegedly doing at Zorro ranch.negative7
u/CBLA1785He is Finnish. Not Canadian. We renounce him.negative5
u/mcolette76Bekah Day did a deep dive on this. Peter Nygard was raping and impregnating women so they would abort the fetuses and this ghoul would have the stem cells to keep him looking young.negative5
u/jake_burgerThose guys look like sex offendersnegative4
u/chingy1337What the fuck4
u/Apprehensive-Style64Whatttt???4
u/KidzinmotionPut these fools under the jail4
u/IamKris7rnHoly crap! Peter Nygard use to try to get young girls in the Bahamas. Fucking creep.4
u/Sweet_Strength1120[deleted]4
u/Apprehensive_Eye_530This is actually happening has a podcast episode featuring Peter’s son! It’s him talking the whole time telling his story. It’s a great podcast in general and a good listen! Edited for spelling I got excited lol3
u/cool_girl6540Offering the women $100 for an egg? Total exploitation. Glad the women were savvy enough to know that that was a totally exploitive offer.3
u/SatirebutinasadwayThis is a fucking "I think you should leave" sketch but it's real. What have they done to us?3
u/benjaminm_4229Super cringe.. I hope the women in the videos are cringed as well.2
u/Large-Mastodon6179Fucking nuts ….2
u/Adventurous_Pie6362It's over. Humanity, I mean. Just enjoy the rest of your life as best you can and don't bring anyone else into this world.2
u/georgedupreeI said what I said when I said it, our Prime Minister needs to be investigating any and all ties to Epstein and the files up North.2
u/ILoveinfo9911Creepy weird sick men👺👹2
u/b15d1ckThey damn know how to talk in cryptic languages in all these files...2
u/Gabagool1969A family member worked directly for Nyguard’s fashion company in the ‘90’s (fam directly reported to Nyguard). Fam wasn’t looped into to any of his crimes, but said Nyguard was a horrible person and boss. Example: Nyguard demanded shitty company policies, like that work-related air travel had to be done outside of normal business hours (on nights/weekends). Nyguard’s secretary booked all airfare to ensure flights adhered to this policy. Also - Nyguard once settled with a woman that was bitten by an emu at one of his “feather parties”. Nyguard personally invited employees to these parties by gifting them a “feather” & invitation. Fam was never invited to these parties, but mentioned they happened at Nyguard’s SoCal residence. After fam quit, Nyguard went out of his way to rat-fuck fam by giving him shitty references.2
u/BSTARYOUNGGYukkkkkkkkk1
u/Sterlingsgma1ALL MY CHILDREN??😓💔😡🤬1
u/MarinaEnnaObjectifying them in the worse way possible, and trying to pass it out as a complement 💀1
u/Mundane_Front659All of the transcripts of what these guys and other rich people and politicians used back then for private communications was on ECHELON and will probably never see the light of day without massive public outcry because it's a tool still used by rich people today to manage their lives through their government connections, especially the Rothschilds.1
u/Spicy_Pickle_6Disgusting conversation at the table wtf1
u/babyblew82Why was ONE of the broads not blurred out?1
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13r/InterstellarKineticsEXCLUSIVE: Scientists just discovered a protein that reactivates stem cells in a...InterstellarKinetics17510%3979.4stem cell therapy2026-03-20↗
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u/InterstellarKineticsThe DMTF1 finding is compelling on its own, but the bigger story is what it represents in context. Three years ago, telomere lengthening in living humans was theoretical. Today there is a human clinical trial showing an FDA-approved pill does it, a Stanford study showing stem cells can be rejuvenated with a single molecular exposure, and a Harvard scientist standing at a global summit saying aging is reversible. The science did not inch forward. It accelerated. Do you think we are within 10 years of a clinically approved anti-aging therapy that measurably reverses biological age in humans?positive31
u/EmberMelodicaIve been saying to people for a while, my generation will be the first to see immortality. Whether it's through biological advancements like this, or through technological replacement.positive16
u/SteambunsinvasionOh , dictators will live longer now…negative12
u/VoodizzyCan this apply to dogs? ?neutral9
u/ahmtiarrrdCue billionaires ensuring they have exclusive access to therapies based on this breakthrough in 3... 2... 1...negative7
u/baycentersDMTF1!1neutral5
u/poopinWell, this would explain why billionaires are building bunkers.negative5
u/bardmalliardSo what vegetable am I supposed to eat to get this? ?negative4
u/Whatislifeabout24Does this also work on TBI? ?neutral2
u/wvuroxxLet’s goooopositive2
u/Mooseguncle1No one here thinks this is how we wake up to a zombie outbreak?😷 ?negative1
u/OMGWTFBBQBRTStoked to see the story 2br02b come into fruition!positive1
u/Candid_Koala_3602And the replicators level uppositive1
u/opalvegWho wants an increased rate of brain cancer? ?negative1
u/derpindabAs someone with MS, I will take two. Thank youpositive1
u/beyondbarrelsso eat more protein bars? ?neutral1
u/Opening-Winter8784This is nice and all, but can we not.negative1
u/Hungry-Ad7987Suddenly your mortgage extends to 300 yrs.negative1
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14r/medicine"Once I’ve met my deductible…”Apprehensive-Safe3824520%9979.0PRP knee treatment2026-03-21↗
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u/Kyliewoo123Wouldn’t it be nice if we could just practice evidence based medicine and our patients could just get the medications they need?948
u/unaslobHow bout the pts that show up third week of December looking for you to arrange their echo, stress and colonoscopy (that you recommended in April) before end of year because they met their deductible. ‘Well I’m not going unless you can get it done next week’ as if they are punishing me.360
u/Interesting_Owl7041My dad just went to the pharmacy to pick up his Mounjaro, which he is prescribed for his longstanding type 2 diabetes. They wanted over $1300 for a 3 month supply. My dad is 83 years old and on a fixed income, but he’s over the income threshold where he would receive any financial help. He called the insurance company to double check and they told him that the price was correct, he has to pay $2000 out of pocket for the year and then insurance will cover it for the remainder of the year. This is a problem. I understand that it may not be saving any money if it’s distributed more evenly throughout the year, but paying over $1300 in one fell swoop is not easy for many people. $2000/12 months is about $166/month. That’s a significantly easier bill to cover for most people.220
u/microcorpsmanObfuscation is the weapon of the financial class. People don't understand their effective tax rate either, or their refund being big means they over paid, or how leasing a car fucks them over, or how their brokerage doesn't actually have a fiduciary duty to them and is charging them out the ass174
u/janewaythrowawaayDepends. Whenever I’ve had surgery and asked a certain hospital group for a payment plan they’ve written off my bill. They didn’t report this back to the insurance company or if they did, they didn’t adjust my deductible back down. Also, with some very expensive meds the pharmaceutical company coupon/charity assistance covers your deductible if your state hasn’t closed the loophole. So, no it’s not a situation where you always have to pay your deductible and may as well get it over with. Even if the hospital doesn’t write it off they may bill something like $50 a month affordable to a low income person. The person may simply not have an extra $300/month for the med period.129
u/ShelbyDriverCross post this in r/pharmacy . They'll know.52
u/trainroverInsurance is such a scam, I dunno how Americans are okay with this.42
u/moonsionOh yeah as an Ortho we have shit ton of patients all wanting their surgeries done in December. Because then they would have "met the deductible so the surgery would be 'free', and will be resting at home during Xmas allowing the wound to heal better." Well, guess what? Everyone is thinking that, and I want my vacation in that time of the year as well.41
u/Cautious-Extreme2839I don't understand how the existence of deductibles is tolerated in health insurance? No other type of insurance has an annualised excess - it's per claim only. Which I think is what you guys call a co-pay? What I mean to say is that even for a private insurance based system - the American system seems to be extra fucked up.33
u/CaptainAlexyHigh deductible plans should not exist. It’s essentially a scam that only pays out if you have a catastrophic claim.31
u/RatleoEuropean here.SGLT2 (dapagliflozin) costs 36.31 Eur a month without insurance. If you have health insurance, you end up paying around 6 Eur/a month. You guys really live in a third world country25
u/thlaylirah17Medication copays have to be paid up front at the pharmacy. If you can’t pay, you don’t get your prescription. The bill for the knee replacement can be put on a payment plan.  I agree with you the whole system is fucked, just explaining why someone can “afford” to hit their deductible through medical claims vs not being able to afford it through pharmacy claims.23
u/DocMacgyver107One of the skills I've had to learn in rural primary care was how to get good meds for my patients for reasonable prices. SGLT2? BRENZAVVY from MarleyDrug.com or costPlus Pharmacy for $60/mo, half if you cut the pill. GLP? Generic liraglutide for 75$/mo from Walgreens with Rx go coupon. Inhalers? Canadian pharmacy world.com or cost plus pharmacy. Of course it works better if we didn't have a profit based medical system, but until this country is ready to grow up a lot, we've got to save as many as we can with what we've got.18
u/flamantsWouldn't paying your deductible month-by-month actually be better for most people than having to pay it in one lump sum anyway? It's like a built-in payment plan. I hope you at least tried to explain it to him.10
u/FlaxmooreI see the same thing with therapy and the like, too. My therapy appointments are $200 every two weeks until I meet deductible, then they’re $23.8
u/1234ldAdmittedly, I’m that person filling EpiPen Jrs x 1 for each kid for each location we need one on December 29th because 10% coinsurance even though we meet our $4500 deductible in February thanks to my husbands MEfRVO injections q6 weeks8
u/KoumadinBrenzaavy is $46-49 per month SELF PAY at costplus depending on whether the patients get 30 or 90 days7
u/HanzilolAs a midlevel, we have our shortcomings, but at least we're not completely out of touch with poor people, so we have that going for us. But you're close to getting it. The system is illogical. It exists like that because it makes it proportionally more difficult for lower income people to get ahead. Healthcare isn't just a profitable industry in the US, it's a crucial part of the broad economic system intended to keep the class divide intact.7
u/Miami_Mice2087sometimes the prescription deductible is separate from the surgical deductible. Pt needs to talk to his insurer. You could find out if the drug is affordable through needymeds.org or goodrx.com or a big box/pharmacy chain/warehouse store's cheaper drug list. Or if there's a generic med they can take instead of the expensive brand-name. The pharmacist may be more knowledgeable about that. There's also mail order from Canada or Mexico but that's risky, your refills may not arrive in time. Write a 3 month supply so the pt has plenty of lead-time to order refills.5
u/SpeechPrudent8409Thanks to the ACA health insurers have an incentive to maintain high healthcare costs as they’re statutorily limited to spending 20% of revenue on non-healthcare expenses.5
u/iReadECGsI used to take one big 2+ week vacation at the end of the year and not much else. I had to move it because patients all wanted their cardiac procedures right at the end of the year because of their deductibles. If we missed 12/31, then would sometimes just disappear (or worse) until the next year causing delays in important care.3
u/herman_gillI am so glad, and also so sad for my former patients in the US that I am no longer practicing in the US. In Ontario (Canada) for Trillium drug coverage patient's out of pocket expenses are capped as 1% of their income every 3 months for covered drugs. Any hospital based care is literally fully covered. Although at the same time this is annoying because I can send a patient for an EGD+biopsies to check for H. Pylori and that's fully covered, but they have to pay $50-100 out of pocket for a urease breath test or H. Pylori stool antigen, unless it's done inside of a hospital.3
u/RdthedoI hate bandaid medicine. With that said, one potential variant of bandaid medicine for this scenario is to use manufacturer’s coupon (which sometimes works towards deductible as well). I had an expensive med a while back, and the coupon lowered cost to like $50/mo or something until deductible was met (difference of med before coupon still worked against deductible), and within a few months it was down to $15/mo.3
u/HOSTfromaGhost…an to make it even more complicated, sometimes medical and pharmacy are two different deductibles. Their plan design is the lynchpin. Folks need to read their EOC to see what’s covered and to what extent. Better yet, dump the EOC into an LLM and create an agent to help you understand your benefits and cost shares.2
u/dpzdpzThat's also why US tax law is complicated. As a bonus, it's written by those who make a lot of money.2
u/Sjeljakt0I mean just read the comments in this thread in the medicine subreddit. Most providers don't even understand individual plans let alone the broader economics. Part of the reason they can be so cheap in other countries is because the US overcharges. It's an inconvenient truth that many choose to ignore that without financial incentive, the rate of medical developments would slow to a crawl. Someone, somewhere has to pick up that bill. Are there better ways to do it than we do here? Absolutely there are. Is there downright evil overpaying of CEOs and other stake holders? Also absolutely. But anyone pretending that we can just switch to socialized medicine in the US and there won't be any broader impacts is intentionally ignoring half of the picture.2
u/DrTestificate_MDThe order of claims can only matter if there is a difference in coinsurance. If you had the luxury of ordering your claims, you would want to put claims that would have coinsurance first so that it eats up the deductible anyways. But I think this is generally a niche case any not really applicable for most people.2
u/halp-im-lostHonestly as I’ve gotten older I have come to realize a good portion of adults have the financial literacy of a ham sandwich. So, yeah, not surprised your patient doesn’t understand their plan doesn’t make financial sense.2
u/bikerchickellyI can make payments on a hospital stay. I can't make payments on my monthly meds1
u/A_Cute_InfarctionSending thoughts and prayers from the British NHS ❤️1
u/FreedomInsurgentwe have a love- hate relation with insurance companies. Docs generally oppose universal healthcare because they think it would decrease salaries, but patients get shafted by this for-profit bullshit.
u/trixiecatI tell my patients to do what I do - put money aside every month planning ahead for next Jan when insurance resets. I tell them to pick lowest out of pocket max plan they can as they will meet it. Just know you will pay 1-5k$ first few months of year and budget accordingly. This does not work for the donut hole patients sadly. Just the ones who suck at thinking ahead-1
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15r/WhyWereWeOkWithThisWoody Allen tries to humiliate Twiggy — 1967AdrianaLaServing11210%3378.9PRP knee treatment2026-03-21↗
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u/EphemeralTypewriterPoor Twiggy! :( Woody Allen is such a scumbag (for multiple reasons), and trying to humiliate a 17 year old just for the sake of it is so pathetic.278
u/Proper-Ad-8829She was 17 and being asked this! 🙄 so obnoxious154
u/blue-to-greyThe way she got him on the ropes I wouldn't even know she was embarrassed.134
u/WhiteMouse42097Woody Allen’s answer is way more embarrassing for him97
u/Riot502This reminds me of the time years ago, when I was young and pregnant, working at a gas station in New Orleans. These two 30-something guys in suits were at my register, and one of them pulled out a $100 bill. He smugly asked me which president was on it. I smiled and said, “Benjamin Franklin, but he was never President.” The audacity of that man to assume I didn’t know who was on my country’s currency, or who the presidents were!58
u/Particular_Web8121I'm so tired of Woody Allen being alive26
u/dontforgetthisone13Love her confidence. “Who? I want to know their names.” Woody Allen realized he wasn’t speaking to someone who was backing down.15
u/imper_foratedI hate this mf with a passion but this feels like a skit that they were both in on7
u/Djiril922How did he even ask that question without having a single philosopher of his own in mind?3
u/RememberToBuyMilkAllen is a complete prick and I’m so glad Twiggy bodied him here3
u/cheshirebutterfly17She handled it with more grace than I would’ve She ended up humiliating him and I did laugh at that . Idk how sad you have to be as a grown man to try to humiliate a teenager I side eye the fuck out of people who defend Woody Allen2
u/cheshirebutterfly17We need a fuck Woody Allen flair1
u/AdrianaLaServingHere is our sub’s intro post! — I just want to clarify one thing for future reference as it’s a point that causes me a bit of anxiety — I do not use ChatGPT or any other LLM to write these!!! I am fond of em dashes because of how they help grammatical structuring, and am autistic — which actually causes writing to be mistaken as LLM generated — possibly leading to the ‘similarities’ between my writing style and LLMs. This is a concern for me, as a neurodivergent person, and I want to clarify before anyone may misinterpret my posts. Our subreddit will not allow LLM generated text. Thank you.
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16r/MounjaroOne Year Summary of the Mounjaro ExperiencePit-Guitar8170%3978.6PRP knee treatment2026-03-12↗
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u/UghaboomerYou look fantastic! 🤩. It’s amazing how one weekly shot can change someone’s life so drastically. I imagine your band’s fans have reacted very positively to your changes.21
u/gazelle999An enjoyable and pleasant read. Wish you all the best.13
u/Magnet2025Thank you. Very informative and interesting read. Even after borderline diabetes (with occasional drifts into the diabetic range) and being obese and having heart disease, my old insurance company denied GLPs (both Ozempic and Mounjaro) 5 times. I tried compounded solutions but didn’t see much benefit. When I switched to Medicare, with the same insurance company providing prescription drug coverage, they approved it. I am starting my 3rd month. I avoid the scale because I can obsess about that metric, but I can see the difference in my waist and chest and even my legs. I have arthritis in both knees so walking for exercise has been a challenge, but I’ve taken 4 minutes off my average per mile walking pace in two months. I used to have a very sweet tooth, and now I hardly crave sweets. The same with bad carbs (chips). Although I wasn’t much of a drinker, I can’t remember my last alcoholic drink. I’m in it for the long run. Thanks again for telling your story.7
u/Ok_Bus8364Rock on! 🎸7
u/Plus_Rip_1919Congrats on your success in sharing your story. 🎸5
u/Pit-Guitar[deleted]5
u/Atkins_OfficialCongrats on all your progress! You look great! 😊3
u/Affectionate_Rub_436Amazing work mate3
u/Few-Performance3192Wow! You look amazing3
u/GardenFragrant8408Congratulations  69 F 5’0 type 2 with other health issues.  Been on mj since 3/24.  What an awesome accomplishment.  My Highest doses 10 mg  but Now on 5 mg to keep from losing more weight.  I was able to reduce some meds and discontinue others.  Mj is a Godsend to most of us. I didn’t have to lose as much as you did but lost 50 lbs.  Congratulations again and good luck with continuing success2
u/Fun-Sort6191Great work. Can I ask your age?2
u/ShiftyMcHaxThank you for sharing your experience and congratulations on your phenomenal success.2
u/skewbydoomGreat job. Congrats. Sweet tele !!!2
u/Brief_Skin_3783Parabéns pela conquista. Adorei ler o relato da sua experiência com o Mounjaro .2
u/Street-Hurry928Fantastic2
u/fnaahcongrats! you look amazing! ... but not as amazing as that Tom Anderson tele. what a stunning thing2
u/Emergency-Major-5213Matt Groening, is that you?? 😳😳😳 Also, Rock On man!! 🤘🏻🤘🏻🤘🏻2
u/M1cksterDo we all get a Tele when we hit a year? Congratulations-great journey!2
u/rm1618Way to go!!!1
u/bakeflyWhat are the  unpleasant side effects that anyone are experiecing?1
u/MastodonStunning6811Well done you look great!!1
u/MelliemelliexoIncredible! Well done to you!1
u/LizzieSilverChairFantastic results you must feel AMAZING!1
u/YoungCheazyI know there are some side effects, but never seen this drug change the color of someone's guitar before...1
u/MinutePalpitation60Congratulations and thank you for your wonderful essay!1
u/daa2202Congratulations! And…nice G&L, and REALLY nice Anderson. You are obviously a man of refined taste.1
u/richmondsteveExcellent! Great job!1
u/Bug_CalmAmazing difference. Well done!1
u/Defiant_Mom_105WOW, Congratulations1
u/Informal_Map3162Impressive! Btw, you looked like Matt Groening before.1
u/Original_Beyond_8798Good for you!1
u/Awkward_Image6095That's quite the transformation. Congratulations1
u/Junior_Jellyfish1865congratulations1
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17r/warriorsMedical analysis of Moody's injury, timeline, and future performancelegitbean4140%8678.2PRP knee treatment2026-03-24↗
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u/Certain-ResolveHopefully he takes as long as he needs. This same injury happened to kelenna azubuike on the same exact kind of play and he was never the same after.201
u/Mundane-Structure148damn. so we may not see moody until 202892
u/noodlebballWho are these 13 players that have suffered this injury?39
u/picks_and_rollsQuestion for OP. Do you have thoughts about why, with more advanced equipment (including sneakers), training regimens, knowledge about ideal recovery times between workouts, advances in sports medicine, training staff, therapists etc…why are we seeing more injuries than in decades past?23
u/megaminor23As someone who personally suffered a torn patella tendon while playing, albeit non-professional and as a weekend warrior, the recovery process is a long and grueling one. Seeing this happen brought back some PTSD especially seeing that noticeable gap where the kneecap should be. In comparison to an ACL reconstruction, the goal is to get mobility and bending quickly, a torn patella tendon limits the range of motion on the knee and the goal during the rehab process is to slow regain full degree of bending. Part of the rehab process is regaining muscle mass in the quad as the entire leg is immobilized for a long period of time. In my case my leg was immobile and in a hinge brace for 2 months and I wasn't allowed to take it off until I got to 90° bend in the knee. Overall, it took me 2 months to walk uncomfortably without the crutches and extensive rehab around 6-8 months just to regain strength to handle everyday movement. 6 years later my quad is still significantly smaller than my non-surgically repaired knee but have been able to play basketball and other sports relatively pain free. Mentally its a tough climb up just being able to trust your body to move the way you used to. As a freak accident its hard to just get back to wanting to play again, let alone walking with basically what will be a brand new knee. Hoping for a successful recovery for Moody as he's been a bright spot this season and will hopefully bounce back to be a solid contributor to the future of this team in whatever way possible.18
u/TeknoStormHey OP! Thanks for posting this. I had a ruptured patellar tendon on both knees (separate times - 1.5 years apart). Right as I saw it, I guessed it was the patellar tendon. Feels like some one hitting your knee as you jump up.9
u/bouncyboatloadwhy does this tendon tear? is it due to weakness in surrounding muscles? or over stressed over time? basically my question is is it a gradual stress that cause eventual catastrophic failure, or is it just a random event that can happen to anyone?8
u/Longjumping-Branch36NRL player Connor Watson ruptured his patella tendon in 2023. Worked his way back to a full recovery back to first grade including playing state of origin for NSW last year, which for non-Australian who don’t know rugby league is essentially among the highest of rep honours7
u/aahdinWith how his knee looked what would you say the odds are on dislocation vs patellar tear?7
u/EngineDisastrous672How long did those 10 players generally take to return to play?6
u/Hop830I missed the game but saw the screenshot of the knee when he was down. That looked really bad. I hope Moses reaches out to Shaun Livingston for some advice. His career was best case scenario for this type of injury.5
u/RedditSuxCoxAgainGoddamn.3
u/YoItsThatOneDudeOuch, thats fuckin brutal, best of luck to him3
u/chrisz2012There are too many games to be played with NBA cup games and 82 regular season games. National Team games for US, Europe, or LATAM in the summer. The NBA 100% needs to stop having its players play close to 100 games a season. The schedule of back to backs is grueling and it clearly shows with all the constant injuries league wide3
u/pancyfantzDamn.. so this is super rare? Sheesh. Fuckin hell. Goddamn… guess Moody and Butler can talk IQ for a while. Fuckin hell.3
u/LebasketBallIs it possible there was a wet spot that he slipped on?3
u/Empty-Dragonfruit194Will he get treated back in the bay?2
u/giantPotatoKing9Thanks for the post and could you share whether medical technology has been advanced in last 5 years to handle this? It seems that most of those the 13 players had that unfortunate injury 5 years ago?1
u/kennyslikMore of a personal question, but how do we prevent these kinds of injuries? Seeing these non-contact injuries like this out of the blue makes me paranoid it could happen to me on the court too1
u/wdsoul96I have no doubt that he'll come back stronger and better player. He's a smart/celebral kind of player. While his play demand (only some) physicality (only really in defense, he needs to act as a sticky hands-up wall barrier), it's not as much as most of the 13 others (same type of injury). He had been trying to assert himself and try to play dominant/intimidate ball. His physique and play style doesn't need to. The only thing I worry about is coming back and playing scared/avoidant. I don't think that'll happen. I think he'll prob follow Steph's trajectory. Where he'll train/play smarter and become even more physical. Warriors got one of the best infrastructure in NBA.1
u/imaaaginarymuffinI can’t shake sadness for Moses on this. He was looking so prime after all those games out. What a damn shame for him and the whole gang.1
u/Due_Cod_7018Damn.1
u/[deleted]lol shit. Gat damn, shit looked ruff-1
u/PhillipMcKrakCall me a negative Nancy. This injury is likely a career changer, if not a career ender. Shouldn’t expect much meaningful contribution from Moody from this point onwards.-1
u/Useful_Coyote_5796His career will never be the same.-4
u/mithrilmambaLooks like Moody won’t get to play with LeBron lol-9
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18r/immortalistsAging is caused also by Telomere Shortening. By boosting Telomere Lengthening me...GarifalliaPapa4330%5476.9induced pluripotent stem cells2026-03-20↗
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u/GarifalliaPapaI am writing this for the other scientists who are interested in the aging science (advanced mechanisms): Telomeres are specialized DNA–protein complexes composed of repetitive TTAGGG sequences that cap chromosome ends, functioning as both replicative buffers and genomic stability guardians. Due to the end-replication problem inherent to DNA polymerase, a small portion of telomeric DNA is lost with each cell division, establishing a progressive shortening process that acts as a biological clock. However, telomeres are not merely passive counters; they also serve as sensors of cellular stress, integrating oxidative damage, inflammation, and metabolic dysfunction into signals that determine whether a cell continues dividing, enters senescence, or undergoes apoptosis. When telomeres reach a critically short length, they lose their protective T-loop structure, exposing chromosome ends and triggering a DNA damage response mediated by ATM and ATR kinases. This activates tumor suppressor pathways such as p53/p21 and p16INK4a/Rb, enforcing permanent cell-cycle arrest known as senescence. This phenomenon underlies the Hayflick limit, which defines the finite replicative capacity of somatic cells. In this state, cells remain metabolically active but lose proliferative ability, contributing to tissue aging and reduced regenerative capacity. Telomere shortening participates in a self-reinforcing feedback loop that amplifies aging processes. As telomeres shorten due to replication and oxidative stress, they activate DNA damage signaling, which induces senescence. Senescent cells then secrete a pro-inflammatory mixture of cytokines, growth factors, and proteases known as the senescence-associated secretory phenotype (SASP). This inflammatory output increases local and systemic oxidative stress, accelerating telomere attrition in neighboring cells. The result is a propagating wave of dysfunction that spreads across tissues, linking cellular-level damage to organism-level aging. This mechanism has clear implications for disease. In cardiovascular systems, telomere shortening in endothelial cells impairs vascular repair and promotes atherosclerosis. In cancer biology, short telomeres initially promote genomic instability through chromosome fusions and breakage–fusion–bridge cycles, increasing mutation rates; however, advanced tumors often reactivate telomerase to maintain unlimited proliferation. In neurodegeneration, reduced regenerative capacity combined with chronic inflammation contributes to neuronal loss. Metabolic diseases such as type 2 diabetes are also linked through inflammation-driven insulin resistance and cellular dysfunction. Strong causal evidence for telomere importance comes from genetic disorders such as dyskeratosis congenita, where mutations in telomerase components like TERT or TERC impair telomere maintenance. These conditions produce premature aging phenotypes, including bone marrow failure and organ degeneration, demonstrating that defective telomere biology alone is sufficient to drive systemic aging-like pathology. This reinforces the concept that telomeres are central regulators of long-term tissue integrity. Telomere attrition is significantly influenced by oxidative stress and inflammation, making lifestyle factors critical modulators. Combined aerobic and resistance exercise reduces systemic inflammation, enhances antioxidant defenses, and improves mitochondrial efficiency, thereby lowering reactive oxygen species (ROS) production. Chronic psychological stress, in contrast, dysregulates cortisol and activates inflammatory pathways such as NF-κB, accelerating telomere shortening. Practices like mindfulness and meditation have been shown to increase telomerase activity and reduce stress-induced damage, while adequate sleep supports DNA repair and limits inflammatory signaling. Nutritional inputs modulate telomere biology through redox balance and metabolic signaling pathways. Polyphenols such as those found in green tea, resveratrol, and quercetin activate protective pathways including SIRT1 and AMPK while inhibiting NF-κB, reducing oxidative damage to telomeric DNA. Curcumin exhibits strong anti-inflammatory effects and can stabilize telomeres in normal cells, though it may inhibit telomerase in cancer contexts. Micronutrients like vitamins C and E act as antioxidants, magnesium supports DNA repair enzymes, and vitamin D modulates immune responses. Omega-3 fatty acids further reduce inflammation and are associated with slower telomere shortening in longitudinal studies. Telomere length can be actively maintained by telomerase, an enzyme composed of TERT and TERC that extends telomeric DNA. While most somatic cells have low telomerase activity, certain interventions aim to enhance it. Compounds like TA-65 have shown modest telomere lengthening effects in humans, though variability exists across cell types. Hyperbaric oxygen therapy induces adaptive responses involving HIF-1α and antioxidneutral24
u/Mammoth_Mission_3524I take astragalosides, specifically Astragaloside IV and Cycloastragenol. I usually take 15-20mg a day of each. I also take NOVOS Core, which has Vitamin C, fisetin, magnesium malate. I take high doses vitamin D as well. I am 50 now, but will likely look like I am 6 next year, lol. 😂 There is a potential downside to lengthening telomeres. It may actually cause cancer. So, there’s that small itsy bitsy issue.neutral24
u/No-Falcon631Interesting, thyme has a positive effect on telomeres.positive12
u/ComplexTell25Can anyone TLDR are the stuff that lengthens telomeres? ?neutral5
u/Del_PhoenixI wonder if anyone has tried killing the telomeres? ?negative3
u/Adventurous-Soft-399I read an article recently about the worlds longest living woman maria branyas who had a huge erosion in her telomeres. She died aged 117. Scientist reckon that having short telomeres helped her live a long life and while long telomeres matter in younger people in old people the short cell life helps the body evade cancer cells.i think be cautious with trying to lenghten telomeres it might do more harm than good.neutral3
u/[deleted]Epithalonneutral2
u/Naven71Currently taking Epitalon. Wish there was some way to monitor and track the size of our telomeresneutral2
u/awesomes007I’ve had at least six years stolen from me by post viral damage. I’d love to have them back.neutral2
u/No-Poetry-2695Nice so much infoneutral2
u/MondoDismordoI was recently contacted by a company that produces a compound THEY say repairs telomere length. They wanted help with marketing their "compound". Fair enough, looks interesting. However, when I asked them about long term (like 10-20 year) clinical studies confirming their claims (so I could reference them in the marketing materials), they ghosted me. That was 6 months ago. Which is why I was attracted to this "article." Unfortunately, this reads like optimistic science journalism dressed up as authoritative medical writing, cherry-picking promising findings while glossing over uncertainties, risks, and the huge gap between mouse studies and proven human therapies. I won't even get into how much of this is AI generated. Just remember, AI's LOVE lto produce ong lists of things. And then the AI generated replies that go on for 10+ paragraphs. Good lord people, enough already. Remember, being cynical and skeptical is a good thing. Helps keep us all honest. (and yeah, we can easily tell when you are using AI to bolster your claims, it's not hard to see) Be well people, and don't believe everything you read on the Internet.neutral2
u/tollbooth_inspectorThe longevity field is a farse, and it is not coincidental we are seeing a push for it now. Elites are afraid of death. We have the tools now to really play with our biology, and it will not end well. People don't realize how incredibly complex biological systems truly are. They have been evolving and optimizing for millions of years (hominids alone). Every step we stray away from our optimized conditioning (hunter-gatherer, nomadic lifestyles) is a disruption to very complex cellular and genetic machinery. It's a hydra problem. In a fundamentally entropic reality, there is always a tradeoff to these sorts of things.negative2
u/Nook_n_Cranny1Regular exercise will likely prove to be the best supplement to prevent telomeres shortening.positive2
u/SenselessSilenceEpitalon (100-500 mcg subcutaneous), first ten days of every month. Over time, it keeps your telomeres elongated.neutral1
u/perkinsonlineDon't forget tunmo (Wim Hoffman breathing) too.neutral1
u/AwesomRenoIt’s a good hypothesis. I don’t think we are actually near the part of knowing distinctively the cause. Might even be a feedback loop we aren’t even aware of yet. Or could be as simple as cellular nucleus wall degradation. I remember learning a guy in Reno was trying for the longest time but all of the organisms always died from tumors or cancer metastasizing. Like, it be cool if it was actually the cause because it would make sense losing DNA over time ends the cell anyway but why does this mechanism exist?neutral1
u/Bobbyg2287Lobelia root...I think lolneutral1
u/Crypto_gambler952Longer telomeres mean more cancer though right? Cancer in old age is better than dying young though I suppose. ?negative1
u/GarifalliaPapaBest scientific research: [1] Telomere Length and Its Association with Aging-Related Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC11882723/ [2] Short Telomere Length and Increased Risk of Age-Related Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC3112149/ [3] Telomere Biology Disorders and Dyskeratosis Congenita Genetic Testing Panel https://dnatesting.uchicago.edu/tests/telomere-biology-disorderdyskeratosis-congenita-panel [4] Effects of Lifestyle Interventions on Telomere Length: Systematic Review and Meta-Analysis https://www.sciencedirect.com/science/article/abs/pii/S0047637422000768 [5] Obesity and Accelerated Leukocyte Telomere Shortening https://pmc.ncbi.nlm.nih.gov/articles/PMC9199514/ [6] Stress, Diet, and Metabolic Factors Associated with Telomere Length Changes https://pmc.ncbi.nlm.nih.gov/articles/PMC3384690/ [7] Vitamin D3 and Omega-3 Fatty Acid Supplementation Effects on Telomere Biology https://pubmed.ncbi.nlm.nih.gov/40409468/ [8] Polyphenols and Their Molecular Mechanisms in Regulating Telomere Biology https://pmc.ncbi.nlm.nih.gov/articles/PMC10049696/ [9] Telomeres, Telomerase, and the Effects of Curcumin on Aging https://pmc.ncbi.nlm.nih.gov/articles/PMC12650488/ [10] Telomerase Activator Supplement Increases Telomere Length in Humans (Randomized Controlled Trial) https://pubmed.ncbi.nlm.nih.gov/26950204/ [11] Hyperbaric Oxygen Therapy and Telomere Length Extension in Humans https://pmc.ncbi.nlm.nih.gov/articles/PMC7746357/ [12] Telomerase Gene Therapy Delays Aging and Extends Lifespan in Mice https://pmc.ncbi.nlm.nih.gov/articles/PMC3494070/ [13] NMN Supplementation and Its Effects on Telomere Length in Middle-Aged Adults https://www.nmn.com/news/nmn-improves-telomere-length-blood-cells-middle-aged-people [14] Yamanaka Factors and Partial Epigenetic Reprogramming in Cellular Aging https://drclarkstore.com/blogs/news/partial-epigenetic-reprogramming-using-yamanaka-factors-reversing-the-clock-on-cellular-aging [15] Biological Aging in Lobsters and the Concept of Negligible Senescence https://www.nhm.ac.uk/discover/are-lobsters-immortal.html [16] Senolytics Reduce DNA Damage and Telomere Dysfunction in Endothelial Cells https://agingcelljournal.org/Archive/Volume3/senolytics_reduce_endothelial_cell_dna_damage/ [17] Effects of Dasatinib, Quercetin, and Fisetin on Cellular Senescence and Telomere Function https://pmc.ncbi.nlm.nih.gov/articles/PMC10929829/ [18] Meditation-Induced Psychological Changes Linked to Improved Cellular Health https://www.ucdavis.edu/news/positive-psychological-changes-meditation-training-linked-cellular-health [19] Evidence on Meditation and Its Potential Effects on Aging and Telomeres https://www.cnn.com/2014/07/10/health/can-meditation-really-slow-aging [20] Longitudinal Study of Senolytics (Dasatinib, Quercetin, Fisetin) on Aging Biomarkers https://www.aging-us.com/news-room/A-Longitudinal-Study-on-Dasatinib-Quercetin-and-Fisetin-Senolytic-Interventionspositive
u/AdvancedWafer2470The Planet Earth is already over populated. Let the young ones rule.negative-8
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19r/MultipleSclerosisJOHN HOPKINS UPDATE!Emotional-Mud-86843090%8276.8stem cell therapy2026-03-12↗
commentercommentsentimentupvotes
u/mullerdroolerThanks for sharing but one thing I want to dispute about diet is (if you can't pronounce it, don't eat it) Psudo scientists and wannabe gurus often say things like this but often simple ingredients like salt or vitamins have their scientific names on ingredients. Just coz you don't instantly recognise it doesn't make it bad. Do a quick Google search of ingredients then decide. It might be a nasty preservative or a simple healthy thing your body needs.59
u/Material_Sundae_5832Thank you so much.. this means a lot. You reported back very quick. And looked and took time to respond to all the questions. You are a very kind person.51
u/MoonElf19Also RE effective medication on the market: it's spelled Kesimpta (ofatumamab) It's what I'm on, happy to hear it's a top suggestion!11
u/HerBonsaiGirlI find that research hospitals tend to be the most dismissive of the lived experience of smouldering MS.10
u/spunkerella75Thank you for reporting back and so fast!8
u/worried_moonThis is so interesting! Thank you for managing to answer so many of our questions when you have a lot on your plate yourself. I’m going to stop worrying so much about my Octave results - if John Hopkins doesn’t care about it yet, maybe I should boot it from my headspace. There’s not a lot of extra room there anyway. Smoldering MS is def a thing, but not everyone talks about it that way. Some say PIRA. It’s definitely an issue - and maybe THE issue for me at the moment - but I can understand why it’s not discussed at your first appt. And…they don’t really know what to do about it anyway, aside from the great advice that they already gave you (strength training, DMTs, etc). Thanks again for doing this for us!7
u/LaurLoeyhttps://youtu.be/IaCdmu61T8k here is my neuro talking about octave. i found him when i googled his work. 😂 now i know these big conferences are a thing….6
u/EthyrumThank you. I’ve gone to Hohns Hopkins MS center for 10+ years and have been happy with the care. The answers to the questions you posted sound similar to what my neurologist there would also say. He said the octave test is a bit too new and doesn’t have the standardization yet for it to be meaningful. I trust what I’ve been hearing from this MS center and feel like I’ve received quite good care. My neurologist there are also answers any messages I send through the portal quite quickly.6
u/Roger_VandenbergheWould have loved to hear their opinion on everything gut health related and spinal fluid transplantation. Like one of the potential therapies i imagine in the future is having your intestines cleaned off any bacteria that's involved in ms (like they do presently for a colonoscopy, the laxative green fluid they make you drink) then transplant a health donors compatible stool. And the chemotherapy thing, i keep on getting about in relation to ms. Basically they kill all your spinal fluid (where your immune cells are made i'm guessing) and again introduce a healthy compatible donors spinal fluid. Also if EBV is suspected to have such a high correlation, you would think a vaccine would be the number 1 priority in these research focused hospitals, no,? Thanks for sharing with us.5
u/MoonElf19Thank you!5
u/Master_Caramel5972Thank you a lot ! I'll look into strength training, I would not have thought it helps with cognitive issue5
u/Did_ya_like_itBless your heart. So kind of you. Love the response to smouldering MS- so fast. But space and time 🤯5
u/Reasonable_Life4852Thank you for sharing!4
u/Isitoveryet_50This is awesome thank you so much ! I'm glad you added that about peptides and sleep. Both both are issues I'm dealing with right now and someone I know is urging me to try peptides as it works for so many things and wants me to get them from Russia. But.. not wasting money on something that no one thinks is going to work. And help for sleep? Thank you for that I will try the Magnesium 2 hours before bed because I don't want to feel groggy when I wake up. All of this is really awesome thank you for sharing!4
u/No-District-9322this is what i needed to read to start seeking strength training. I was thinking it would get my fatigue really worse, but now im considering at least to give it a try4
u/[deleted]Thank you!3
u/PK5002Thank you very much. It's so nice of you to share all this information.3
u/berrattackThank you3
u/NicoleR_24Thank you so much for taking the time to share this. It’s because of people like you that cares so much that can help find a cure for this one day.3
u/buderfwyThank you so much for sharing!3
u/Soft_Cash3293Thanks so much for reporting back 🙏🏻 love to hear about strength training, it's something I really enjoy and it's great to know it's good for us with MS3
u/Many_Theme4441Great post. I’m a lurker reading everything as I’m newly diagnosed. Thank you for taking the time to share the information from your appointment. I hope your appointment personally went well.3
u/my_only_sunshine_Ugh sucks that the one I was most interested in is the one with the shittiest answer (smoldering MS)3
u/CheebissThank you for posting these responses! My husband just had his first outpatient appointment yesterday and the 90 minutes went by so quickly we didn’t get to ask everything we wanted so these responses help! For your eye, did your neurologist mention trying to treat it again before starting a DMT? My husband’s optic neuritis hasn’t totally gone away and he hates steroids so they’re actually going to have him do plasma exchange. They’re basically going to try to rescue as much of his vision as possible before starting the DMT.2
u/chunkykimaThank you for doing this! Saving this thread to come back to and remind myself of those answers.2
u/Kelevra7_Thanks!2
u/Drbpro07Thanks a lot for sharing2
u/No-Establishment8457Thank you for this information! Even as an MS patient for 35 years, always something to learn. Appreciate you.2
u/sunshine_59_Thank you!!!! You're the best!!2
u/mr_bearculesVery interesting and informative. I’m just starting out on my MS journey and so this info is helpful.2
u/raptordamusThank you for sharing, appreciate you!2
u/Thereisnospoon64Interesting re Melatonin. My neurologist flipped out at me when I told her I was on it bc she said it’s completely unregulated plus it causes bad hangovers in the morning. I’ve been on Trazodone for sleep ever since and it’s been great.1
u/LizzieBourbonAwesome! Which dr did you see? Mine isn’t super chatty, but he responded to my MyChart question within 5 minutes today.1
u/No_Consideration7925So you were just diagnosed. I’m so sorry. Yeah there’s a lot of information out there. Hang in there mind your sleep and healthy daily habits, especially with eating lots of nutrients. Xx1
u/No-Armadillo-7393Strange question, still new to this 8 months since diagnosis but what are T-Bands in spinal fluid? I had "O" bands in mine🤷‍♀️1
u/asap_stockyWhat is the eye thinning about? I’m confused1
u/Broman400You lost me at your response to stem cell therapy. It is 100% better than a dmd for a lot of people. AHCST stops disease progression and lasts for years1
u/FewProgress1797Thank you for this. First symptom optical neuritis1
u/NativeSJThis should be pinned for newly diagnosed folks. Well done!1
u/sonoallieWow! Thank you so much for all of this!1
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20r/industrialmusicIt’s time for the industrial scene to stop protecting Jim Marcushell_generator2380%33876.3PRP knee treatment2026-03-20↗
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u/whitlashHave you already given them the screenshots I sent you? I’ve spoken about this publicly extensively already but got the exact same treatment you’re talking about although I have never backed down about it and never will. What he did was wrong and I’ll never forgive him for trying to involve me in the exploitation of someone else.51
u/neverwhere616There's a group called Sounds and Shadows on Facebook that goes along with a review blog. I was friends with the guy that started it until he chose Jim over one of the mods that was very vocal about this shit. Fuck Jim Marcus.36
u/Jonathan-Strang3Who?31
u/whitlashHere’s the question that’s always bothered me- I’m absolutely vibrating with fury from my hair to my toenails that he tried to make me part of exploiting this woman. So… where is all the fury from all the men he turned into r*pists? Who allegedly thought this was consensual but now know it definitely wasn’t? Why aren’t they lining up to give statements to the cops? Seems like they should be angrier than me and yet… crickets this whole time.30
u/adrianhaloI’ve been trying to gather my thoughts ever since I saw this post. There is a lot about my [former] connection to Jim that might not be so easy to explain, but I will try. I’ll start by saying I’m a musician- I am the frontman and for the most part sole performer on my studio albums. I have a handful of friends in Chicago who I still consider my live band even though I moved away almost a year ago. I doubt you’ve heard of my band and that’s fine, this is just for context. So anyway, I first started talking to Jim on Facebook when I was still living in LA in the fall of 2018. I had taken a long break from the scene and had just started working on music, gotten back into my favorite bands, and so on. While at Cold Waves LA, I started talking to a friend who had either mentioned me to Jim (not knowing ANY of this about him, and neither did I) or maybe even sent him a few songs. So Jim messaged me saying he was putting together a compilation to benefit trans rights (I’m transmasc and also queer) and asked if I wanted to contribute a track. As someone who’d first gotten into all the Wax Trax bands as a teen even though I was a little too young to have heard or seen them (I’m 44) in their prime, of course I was over the fucking moon about this and was like hell yeah. So we started talking online and I sent him a few demos and he asked if I wanted to come to Chicago to record the vocals at his home studio. He said I could crash on his couch and hang for Thanksgiving. I was so nervous that at the last minute I almost canceled my flight. But to me, Chicago still represented the motherland of the industrial scene…so I went. What’s crazy to me now is that Jane was there, and she was really anxious and seemed almost jealous that I was there. It was hard for us to work because Jim kept texting her. And I remember wondering if Jim was interested in me Like That, but decided that the music was more important, no matter what. It honestly fucks with me so bad to think of all the expectations I had of that trip and those recording sessions, to think of how I was still early in transition and thus navigating all that uncertainty. Including literally finding my voice. Showing up on his doorstep in my Wax Trax hoodie and my Pigface shirt. Thanksgiving was fun. I met one of the engineers who worked on a couple of my favorite Sister Machine Gun albums, and their former guitarist (Xmas) actually played a few parts on my songs, which was amazing. I met a few other people who later would end up being my friends and bandmates when I moved there. I got back to LA and felt like things would start taking off for me with my band. I began to consider Jim a close friend and we talked a lot. And then by the following year, I decided to move there. I had visited for Cold Waves and it just felt right. There were things about LA that just weren’t working for me and I felt like this would be the first time that I moved someplace because of the people there. I left for Chicago in late February of 2020. So, yeah. There was that. In spite of this, I started building a life for myself. And Jim was a huge part of that up until about 2023. And what really breaks my fucking heart in hindsight is that it wasn’t all bad. Sometimes a couple of his bandmates and friends would come hang out and they’d all tell stories about Chicago Trax and Warzone and all the bands. All the albums I loved. I felt like maybe I’d finally met the right people, in the right place, at the right time. I was there when he and Jane broke up for good and I used to hang out with the three of them (she often brought her son over). I was there when he was hosting that kid in his garage. I met his kids, I was often there around holidays because I didn’t have family in the area, and while we were just friends, we were often affectionate with each other and he said he was attracted to me. So basically I got sucked in. I was there when he had his hip replacement surgery and prior to this, was barely mobile and in a massive amount of pain, so I often ended up cleaning the house and going over there just to keep him company. For most of late 2020-early 2023, I was over there at least once a week. And I started to just feel really…confused. For anyone else with ADHD who has experienced limerence, basically hyper focus on a person…it’s horrible. It’s exhausting and embarrassing. There were absolutely times where I acted fucking crazy because I felt so messed up about everything. He would ignore me and spend all night texting or on Fetlife. I was sort of like this weird platonic rebound to Jane in a way, and he had major Shiny Object syndrome. And then one day I was seemingly replaced by this woman he had played with several years back and gotten back in touch with on Fetlife. He became pretty obsessive about her. Never mind his professed attraction to me and the simultaneous insistence that it would ruin our friendship to do anything about it- our friendship was already ruined. 28
u/Jazzlike_Property_68I'm aghast to hear this. I've loved his music since I was a kid, but this is news to me. Do you have any sources that you could give us for the previous accusers?28
u/Specialist_Spot_3471This is Jim’s second ex wife. I will fully support any young lady or man that has been harmed by my ex. It wasn’t the first and it won’t be the last. He is a covert narcissist that prays on those he considers weak. His joy comes from sitting at a computer pretending he attract someone, pretending he is some sort of dungeon master. Arguing with people online and braking people around him when it suites him. I’m not sure if there are any specific questions for me but I’m happy to share the hell that was my life for nearly a decade. He got his friends to believe the divorce was me trying to steal his money but the man is broke af. He can make money but he never has any. He spends it all on sex stuff presents to lure in younger people . My worst experience was when I was with a 19 yr old friend from school and Jim just outed us without a conversation then invited her to a dungeon all whil we WORKED TOGETHER! It was humiliating the young friend was never to be seen from again after too. He was always trying to bring in 18-19year olds. By the time I hit thirty he disagreed me. He already had like 5 new girls. He called my family members and would tell them he is so worried about me… when he wouldn’t even make eyecontact fuck that pos.27
u/DivaMissZOnce again, we find out that a respected public personality is in fact a sick fuck. I’m so tired of people like Cosby and Gaiman, whose work I loved, I can’t stand anymore because I know they were created by people who are morally corrupt. And it seems to happen more and more. I swear to goodness that I’m going to wake up one day, find out that Keanu Reeves runs an illicit cat juggling ring, and shove my head into a vat of pudding because there’s no hope left25
u/s1l1c0n3Jesus fuck. This really makes me violently ill. Jane, if you are reading this… I hope you know none of it was your fault. You were manipulated by a serial abuser. I hope you get both the help you need and the justice and vindication that you deserve25
u/MilkfixerFaith Marcus tried to tell everyone when they broke up. Something has always smelled. This is so very fucked.23
u/maliciousorstupidWow - first I've heard of any of this. Met him a few times many years ago and he seemed like a good dude, but certainly didn't know him well enough to make a judgement here. If even a fraction of this is true - yikes.23
u/wakarat“All Good Girls” seems much creepier now.23
u/coupdeluneI love Die Warzau's music but I must say from interviews I've read with him he always came across as fucky. This confirmation is just depressing. Fuck him. I hope his victims get the help and support they need.22
u/Specialist_Spot_3471100% I can confirm his way of being as it took me ten years to see him but the mask fell and I did I saw him. Happy to help if someone can let me know how. The being given away at sex parties without getting to have a say and if you try to have a say it’s an argument. His constant cheating bc he is always online looking for a new supply. He is a covert narcissist that pray on young ppl not just women.21
u/LockedOutOfElflandHoly shit. Just a few months ago I remember reading a social media post from his partner about how "he's one of the few guys in this scene that actually treats women with respect", et cetera I can't get that out of my head after seeing this.20
u/Vile_GrifterI just want to express my sympathy for the survivors of this abuse, and admiration for them and everyone else coming forward to try and break this circle of fear and silence.19
u/Maleficent_Energy_55Jesus, the nightmare that poor human was put through. I’ll never be able to listen tonDie Warzaw again and hope that enough people can step forward to shine light on the abuse. EDIT: Just deleted all the Die Warzau and Go Fight albums from my collection. I’m bummed I was a supporter for Go Fight on Bandcamp as long as I was.19
u/FiDRaT2016Really shocked to read this post. I worked with Jim when he lived in Boston. We always got along, but he was always very “amorous” with both female and male colleagues, more than would be appropriate in a work setting. Aside from that, I never witnessed anything to this level. I hope Jane gets the help and support she needs. No one needs to be treated like that. I will also be cutting ties with Jim on social media. Truly shameful.17
u/unsoundamericaThis was a painful thing to read and then reflect on. May the victims find peace and healing.17
u/phillyperoxideI’m very sorry and disturbed to read about “Jane” (who I don’t actually know from reading this), but I am here to comment about SLS, as this seems to be turning into a smear campaign about her rather than the actions of Jim Marcus or the victim “Jane” (which seems to be Lengua_Acida’s intention here)… Sarah is one of my dearest friends who I’ve known for 20 years.  She has *not* enabled or protected Jim- and the accusation of him being an abuser is actually news to me.  Although I am of course aware of him and his bands, I am not his friend and I don’t personally speak with him in-person or interact with him online. Regarding the safety of the Chicago scene with Jim- I literally only see him once a year at a specific event, which is Cold Waves. He does not attend Sarah’s events, nor mine- though I suppose I can’t say anything about others that I don’t attend on a regular basis. Sarah has always made the safety of our scene a top priority. I’ve learned a lot from her over the years and her dedication to keeping this scene alive, vibrant and most importantly, safe. She actively keeps predators away when made aware, as do I. I know for a fact that people can vouch for that, as we’ve made other venues / promoters aware of banned individuals for other events we’ve been a part of. We clearly would never support an abuser like this and would ban them when this knowledge was brought to our attention. I cannot speak more highly of Sarah as a genuinely lovely, caring, passionate person who wants the best for our community. This is a person that I’ve spent time with over many years not only working in nightclubs, but for weeks at a time in tour vans, hotel rooms- you get the idea. I also want to acknowledge that I *never received this e-mail* if it actually exists and I have been actively putting on events myself in the goth scene in Chicago for 15+ years.17
u/quaffi0Who?16
u/ILikeCatsAndSquidsThis whole thread has me so over the Chicago industrial and goth scene. It’s not just Jim Marcus, it’s a whole cesspool of assholes and egomaniacs who never grew up.15
u/razorbladesaladHe is absolutly a piece of garbage.  I have seen the fallout from his treatment of women first hand and heard stories about how fucking creepy he is towards them for years.  Also dont forget his connections to other creepy ass men.  Genesis Silva used to live with him (and was just convicted of beheading a woman).  Anyone who had to proclaim how safe they are as often as Jim does is absolutly not.  I call it the problematic male circle jerk, the way they protect each other and keep each other relevant.15
u/MsefkThere is a small but dangerous powerful circuit of .... lecherous people protecting each other . and hurting anyone who goes against any one of them. edit: and i hate all of these awful controllers , grey forces indeed15
u/Outside-Mushroom-818Since I've gotten older, I don't keep up with the particulars and gossip of my generations past. Having said that, I spent my late teens; early 20's during the zenith of Wax Trax! So. As  I got older and don't keep up with the news. I came into Die Wazau after Wax Trax! Filed for bankruptcy; bought and destroyed by TVT. Though I never cared for politics of personality. I saw a video of Jim Marcus ranting about environmental shortcoming. I thought to myself as I had with the musical heroes I grew up with. It's better if your heroes keep their mouths shut and retire without words. Having opened my Reddit page up, this was the first story on my feed. WTF? is all I can say. It's time for the Chicago Industrial contingent to spit this clown out and expose him and his crimes in a serious light. Trade the repulsion of Jeffery Epstein's crimes and apply to Jim Marcus. The circumstances are identical. Seriously, folks. Time to shut this sexual abuse out and expose those who perpetrate it. I have always been curious about DWs song, 'All Good Girls.' Perhaps a relevatory song?14
u/YellowBeaverFeverI didn’t know who he was. I knew Die Warzau, seen them a few times, never liked them. Never bought an album. This story is messed up.14
u/master_of_sockpuppetNever heard of him, never liked Die Warzau. However: this sort of social closure and protectionism is exactly why “scenes” are almost always bad news.14
u/Specialist_Spot_3471There was a time when I was part of the BDSM community. Jim had asked me if I have boundaries, I had two hard limits due to previous trauma. One was no taking a belt to my chest. And the other was that I do not sleep with brown men, again due to previous childhood trauma. Jim not only pushed my boundary but invited a man over and set up a scene without my knowledge or consent. It was with a man we can call Drew. Drew had a dungeon and his own space but Jim brought this man to our shitty apartment at the time. I didn’t feel like I had a say, bc I already stated my boundaries to Jim. And in the moment one gets caught up in horror of it all. So my boundaries were crossed and in the most of humiliating ways bc that’s what Jim thrives on trying to humiliate others in secret. He uses NLP tactics to groom or brainwash those who are unfortunate to trust him. And it wasn’t another month or so till he tried beating my chest with a belt. Not the leather part ladies. And since it’s humiliating to you he knows you won’t share the story allowing him to always be the story writer. (Let’s be honest tho, it’s all ai with him these days) My point is if I reach out to him today and confront him he will just repeat over and over for me to name one thing he did. Never a fucking apology not accountability. Jut tell me what did I do?! In that horribly depressed and whining eyore voice. Some of you may remember Jim’s race play parties where he again tried to have me service many men and women of color at once…. Good thing I already found him cheating on me otherwise I would have been doing more than just watching and silently suffering. It’s not you Jane it’s who Jim is and there were several women who had nasty things to say about him when I was married to him but he always played it off calling her crazy. Man was I stupid. I could only compare the feeling of how Jim makes ppl feel if you have seen the movie girl in a box… he was trying to get me to help him get younger more beautiful women for his sex parties. An he is not safe. The fist night we ever even had sex he told me after we were done that he didn’t wear a condom but then he immediately follows up with it’s ok, I’m clean.!!! That was terrifiying. And I was made to feel like it was no big deal. So he starts right at the beginning and then just lies to cover everything up. Pathological that one. And for the record I had a rule to not sleep with men of color due to a really abusive step father. Not bc I dislike or hold negative feelings I just have PTSD. And that would exasperate it. There are plenty more instances but I’m better at being asked questions. If anyone has any hit me up13
u/Traditional_You3996Holy crap this is terrible. I hope justice is achieved.13
u/deadgreybirdSobering. I didn’t expect the Chicago connection; this affects events I’ve gone to and was planning to attend in the future.12
u/globe_thistleJesus. This is Sean Diddy Combs-level criminal, in fact, it's worse. I'm so sorry, Jane. You deserve justice, and you have people's support. Scary Lady Sarah should be f'ing canceled. What a scumbag.12
u/midwestbreakcorenow that you finally caught Jim, can we take a minute to address psychotic Sean Payne of Cyanotic?12
u/whitlashI just feel so grateful that Diddy Warzau here might finally be facing some real consequences. I’ve been talking about what I witnessed for three years now and it’s been an absolute nightmare. I’m so glad everyone was finally able to get in one place and tell the truth.11
u/Tyrs-RangerNo idea who this guy was, though I probably heard the name in passing at least once. I skimmed the novels here. Fuck this guy. Maybe he’ll have a hideous accident involving a wood chipper.11
u/EgoCravenHuh....obviously reserving judgement but it's pretty surreal reading this about a person I've exchanged messages and the odd intimate photograph with. Bit of a nasty feeling. Seemed lovely frankly, I mostly knew him through his fetlife writings rather than music. Obviously that's not really relevant but....still not a nice feeling if thus stuff's true.10
u/Moranimal2I imagine Jim’s theory that “there’s no such thing as cancel culture” will be put to a well-deserved test. I heard he has updated his MeToo hashtag to read #BelieveWomenExceptThem.10
u/Any_Sport3353Here is something concrete you can go home with: the debut GOFIGHT album literally has a picture of Faith Kroll’s ass branded with the band logo he designed. Please unpack this public display of ownership at your own leisure10
u/Odd_Improvement_6501I’m going to delete that fuck on my social media and block. Uptick this after you have done the same! Block Him - Jim Marcus.9
u/Odd_Improvement_6501I went to his house for a minute to pick up a friend. There was food and I happened to notice all the glass buttplugs in the shower window by the kitchen. Like you’re having company over and that’s a normal thing and all - but no class - just indicator of what’s to come next? It’s bothered me and I’m no prude. I don’t want say when it was, but within the last 5 years. Too many red flags. Run current partner!! You’re too pretty for him anyway.9
u/jonathanfvDidn't know about Die Warzau, but seriously, fuck Jim Marcus. Anyone truly against all forms of oppression will also be a person who'll make sure to avoid being put in a position where they can exploit others, as well as avoid others becoming completely dependent on them. Anything other than that is hella suspicious. Jim Marcus is a piece of shit.9
u/SlideLoose5008Sarah has been on a power trip as long as I've known her. 1997. I didn't meet him until about 2010. I worked in the industry and never liked him. He just gave me the feeling that he was a scammer in sone aspect. Took a few years to really see his "game". Over opinionated hypocrite and a true scumbag when it came to how he treated woman.9
u/thecoiledoneSo tired of this dude. I'm glad to see these stories getting the attention and condemnation they deserve. I have heard stories about this guy since 2013, and I'm very thankful that I never had any direct contact with him despite sharing circles in both the kink and industrial communities (probably not young enough for him, and/or he was always too busy engaging in flame wars on fetlife with my former partners lol) I hope the many people he has harmed are able to get the support they need.8
u/Specialist_Spot_3471Eli23, moved to Hawaii Lilly21 disappeared, just like brondwyn who was only 19 at th time, maybe I shouldn’t even be saying their names? Idk8
u/LAIndustrialNot denying any victims allegations but let's see some receipts please. We have experience in shining light on cockroaches. Do us that favor and show please. Everything on this read is horrifying.8
u/MilkfixerWhat the fuck.7
u/NachtraafWhen people get popular enough, they get away with a lot of shit. You'd hope that in the alternative scene, people would be a little bit more wary of this, but this type of thing keeps happening over and over.7
u/littleweirdgirl312Are the people who partook in these parties going to be named or just Jim? It sounds like at least some of the participants knew what was going on. If they are also in the goth/industrial scene the danger reaches beyond Jim.6
u/AngelsbreatheeasyThis is scary and makes me sad. The part about the cold waves team considering the singer from one of my favorite bands I’m pretty sure is apart of that… Can someone clarify that part?4
u/fear730Everyone coming here to comment please be civil if I see any Harrasment like in the other post you will be banned PERIOD.
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
21r/RadiologyYou pick em I stick emiradi8u4420%4376.2PRP knee treatment2026-03-27↗
commentercommentsentimentupvotes
u/Kashmir_SlippersYou silly radiologist. Don’t you know how this works? The real doctors tell you what to do, and you do it - no questions. sobs426
u/LoudMouthPigsDeeply fuck this kind of person174
u/moothig"I want you to do something non evidence based because I can't! I will scream into the void until insurance stops paying for it"119
u/DamnGracklesAhhhhhh. Yes. See, the problem is you forgot IR stands for " interventional...whatever procedure every other service doesn't feel like or can't do BUUUUT will only do the way the people not actually doing the procedure want it done regardless of whether it's actually in the patients best interest...radiology" It's ok. It happens. My doctor forgot this last week when he though it was ok to tell a hospitalist he wasn't going to call the team in to place a pleurx... at 8pm.74
u/whatthewhat_007That's really funny because the American Academy of Orthopaedic Surgeons does not reccomend HA injections.48
u/floofienewfieImagine how he talks to regular staff this way if he speaks to a peer in this manner.44
u/supertucciI mean what kind of sorry orthopod can't use office based ultrasound and inject even the fattest knee space.37
u/Wire_Cath_Needle_DocThat boy need some GAE31
u/3oogerEaterI get Euflexxa injections every 6 months. Similar to orthovisc. They have been extremely helpful to me. Insurance covers it, but I’m getting it done in an office.12
u/maw6lmfaooo "we are not looking to expand" is sending me5
u/DamnGracklesSee, I have a hard time understanding exactly what IR is because of stuff like this. Everytime I hear of an "IR procedure" im like, "....when did IR start doing those??"3
u/Admirable_Payment_96Was this a physician?3
u/Occams_ElectricRazorWhat a douchebag.2
u/Wicked-elixirI wonder if it would work better by using it as a facial serum. Haha. Also, they can kindly go fuck off waaaay over there.1
u/Infernalpain92I understand his question. But fucking hell just explain what it is. And don’t be a cun—T. The sticking is probably the hard part. I remember my arthro mri of the shoulder. The contrast run everywhere and basically made the exam loose its function. “Extended sequelae from difficult injection of the contrast medium” How did you decide to go in to IR? It’s a pretty cool branch and a lot of minimal invasive treatments no?1
u/RadsasIdk what’s a big deal injecting a knee! Seriously, I’m a radiologist I do arthrogram on a 350lbs plus patients all the time! You an IR this is your bread and butter why would you say you don’t know what that is. What’s the contraindication to inject an obese patient??? when your referrals start drop you will change your attitude!-1
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22r/immortalistsMore people will want to live forever if and only if they can live forever young...GarifalliaPapa2720%8176.2stem cell therapy2026-03-15↗
commentercommentsentimentupvotes
u/ImDeepStateI can look 50 if I get to live forever.63
u/AttorneyUpstairs4457It’s good to take a moment now and again to remember that it’s only people who have the opportunity to age who actually see aging as a problem. Aging is of course also a privilege that we won’t all have.32
u/Repulsive_Falcon_408If only there was a way to pass down our biological information into a new body that inherits everything we are, yet begins with every cellular process fully restored...14
u/GenuineHMMWVDon't worry, if we don't figure it out and have to die... it won't matter anymore 😃9
u/smart-monkey-orgAnd you can actually help by growing the community - joining r/immortalists and bringing your friends along!7
u/moonracersMost, depending on their age will get their wish. 150 will be the norm, sooner rather than later. In order to truly live for hundreds or thousands of years will require us to toss these bags of water we call bodies. IMO anyway.6
u/TiltedbrimboyScience advances one funeral at a time6
u/MissAmberRI’m 50 already I’m not sure they are going to figure it out in time to save me5
u/Available-Mail-8264Couldn’t care less what age I look if I have the physical and mental fitness I have at 385
u/EnvironmentNeith2017Kind of off topic but aesthetically I wouldn’t want to look 25 again. I find middle aged looks much more attractive.5
u/parkerkudrowI would want to live forever if the planet wasn’t dying and everything wasn’t getting more expensive and worse. What’s the point of living longer if quality of life is horrible?5
u/Antique-Resort6160Honestly i could be old looking, i just have so much I want to do. Another hundred years or more would be great!4
u/OwlKitty2Who cares about looking 25, it’s how you feel that’s important. Living until 125 and feeling 125 would just be a cruel and unusual punishment.4
u/Huge_Line4009I imagine you would also have to work longer, right?3
u/_FIRECRACKER_JINXyou'd think so, right? I don't think it would work that way. Because TECHNICALLY SPEAKING, we ALREADY have a few anti-aging medications called "vaccines". They technically prolong your life, reduce the amount of stress that your body goes through by preventing preventable diseases/infections, and limit the amount of damage your body sustains from preventable infections like COVID, Flu. yet here we are, with a huge HUGE segment of the population being proudly Anti-vaccine. I think if an anti-aging cure was invented. People would respond to it, the SAME way they responded to the COVID vaccine. WHICH IS A GOOD THING, IMHO. We do NOT want the dumbest people living forever, we really really don't.3
u/MrGhost899Ruuuuun!2
u/MegaManSELooking young is actually way easier than actually medically reversing aging. Many Hollywood / politician types already have these techniques down.2
u/Melodic-Berry-8635Are we being hyperbolic with the living forever statement? I can see people wanting to live to the high hundreds or possibly longer if they could be feel/look like they are 25. But seriously who the hell actually wants to live forever. I'm not suicidal, and have a pretty decent life, but I would have been cool tapping out of this world a decade or two ago. I mean there's really only so much you can see or do in this world. Let others have fun playing with this puzzle box2
u/saymellonIf we could somehow get a 125 year old person look like 25, then everyone would want to live forever.  That's a pretty stupid thing to say, though. Why do you think some people in their twenties commit suic***? Not everyone wants to live forever2
u/sakraycoreYep my goal is to look like I'm around 25 years old forever. Basically my longevity stack in a nutshell.2
u/Emergency_Incident32Nah, I will embody the crone phase of life and keep it that way. Aging is a privilege2
u/El_Loco_911There is no self i am mortal and eternal2
u/totoin74Every death would be an accident or a murder if aging got eradicated.2
u/Emotional-Dog-6492You can’t DEFY ageing. Its a genetic program. You can only slightly expand or shrink it2
u/stomachofchampionsProblem is you would become more likely to die from an accident.1
u/ReadwhatudisagreewitAnd what do we do when hundreds of millions people can live well into their 3 or 4th century’s, while populations swell into the hundreds of billions? Somewhere along the line, procreation would have to be restricted.1
u/BriannaPuppetI think that what is actually going to happen is that large numbers of people will have to confront the fact that they hate themselves and can’t wait to die Fortunately, they will have plenty of time to work that out1
u/JonaEnyaI'll fix it1
u/hordak666I want to look like Saburo Arasaka and live forever.1
u/WordPlenty2588When I see this photo I think of sun related aging https://share.google/sgQxfauOCWr2sP0uZ Sun is very good for you, we need D3 and other things... But too much sun is bad1
u/aspiringimmortalAging is barrier number 1. Religion is barrier number 2.1
u/MrGasMan86Nobody wants to live forever. That’s not what life is about. There is no game genie you can just hack life with to live forever and even if you could, nobody would want to. Life is short, delicate, and precarious for a reason. Enjoy what you have TODAY and forget about tomorrow because regardless of anybody says about the future, our time here is limited. Acceptance of that will go a long way for your wellbeing AND your future.1
u/Willing_Progress_646I think also sometimes life sucks so that also plays into ppl being ok with marching towards their death everyday...1
u/Sure_Assumption7857lol, no.1
u/Origin_64The age gene has been found for a while now….if you couldn’t live forever, what age would you want to live to, assuming you still look 25 haha1
u/Independent-Sense532This seems a bit delusional.1
u/SuddenAvocado35 and started taking my metabolic health seriously this year for this reason. I know I won't get back exactly to where I was at 25, but I want to feel good and strong for as long as possible, and if I can capture right now, that will be good enough. I think the biggest difficulty is illness. Even the most fit and healty people can get a serious infection or disease- or even stressful periods- and be knocked out for months or year, and then struggle to return to their previous fitness. This was my case in my early 30's and I fear it will happen again in my later life.1
u/ConfusedGuayabaTrue1
u/Fluffy_Nuts4120if my aunt had balls she'd be my uncle1
u/DrawingCivil7686[deleted]1
u/MrBodaciousMakerIf there was no religion we would have figured out immortality long ago.. but nooo people think there is a magic world after you die instead of just nothing so death is ok 🤦‍♂️
u/Constant-Chance-5245Imagine how horribly overcrowded the world would be and the shortages of food and housing and the strains that living so long could cause…….
u/PsychologicalMethod6I personally think it would be a curse to live forever and even if I stayed as fucking good-looking as I am right now I'd still want to die and see what's next
u/Odd_Spring_9345I don’t think I’d want to live that long with the way the world is looking-1
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23r/mdphdMy Sankey + Giving Back to the Community :)Useful-Bed43963680%5376.1regenerative medicine2026-03-21↗
commentercommentsentimentupvotes
u/Straight_Armadillo32Holy goated congrats!! Well deserved As :)) im also hoping to apply MD PhD but super anxious and dont know if I can make it25
u/Ill_Sleep_589idk anything about the MD/PhD program at UW, but I do know that it’s a beautiful and vibrant place to live! Always moving, squeezed between 2 lakes, and the area is gorgeous.15
u/Sauceoppa29Lisan al gaib level snakey right here. Congrats on the many many As!7
u/Useful-Bed4396[deleted]6
u/Fresh_Market6588okayyyyy miss goldwater I see u!6
u/itsfriccinbatsI’m at UCSD — feel free to PM :)5
u/ChipotleisAssCongrats bud, this is huge. An acceptance to MD-PhD program a massive W. My Aunt did her MD/PhD at UW then residency in Canada, so good luck in your desicion, any school will be lucky to have you :)5
u/SatisestCongrats on the results. Stanford is the best program on your list and perhaps in the country. Highly recommended unless you have specific research interests elsewhere. The MSTP is very cohesive so dual degree students stay on track and integrated into both programs.3
u/Theloveandhatehopefully I'll see you at Stanford this summer <33
u/Increase_CraftyHi, I saw you mention research fit on another comment; are you referring to your own research? as in your own work needs to align with what the university has a big focus on? Or your goals as in you’re interested in xyz field, and that university has a focus on that xyz field? Also congrats and tysm for the resources!3
u/Party-Coffee-4067wow congrats! also thank you so much for the notion. quick question on the LOR’s. How did you build a good relationship with faculty beyond just going to office hours and performing well in class? i feel like im not really standing out at all in this regard.3
u/Ace_PossumHow many PhD programs did you also apply to? And was the plan to see how things were going for MD-PhD applications and then decide if you wanted to apply for PhD programs? I’m considering doing the same but haven’t seen too many people do this. Great to know it is a possibility, so thanks for sharing!2
u/Ices10Would you have taken UCSF > HMS and Stanford. Huge congrats! In a similar situation lmaoo deciding schools.2
u/majormajormajormajoHow did you answer why you needed both degrees?2
u/AntiMarkovnikovFishAmazing stuff! Mind if I ask when you had your secondaries submitted?2
u/Thin_Cold_9320Sir, im going to have to see your whole application and see how it fulfills the core competencies lol1
u/Positive-Sell-5424i know sinai has a really well-known heart center but i don't know much about research there. is location a big thing for you? i think that's a great way of narrowing down your current options1
u/Temporary_Skin5145Wow, congratulations on your As! Honestly, hearing that the writing is a big part of making an applicant stand out makes me feel a bit better about my application. My writing is very strong and I think I've written a pretty cohesive narrative, but I was very worried it wouldn't matter much compared to my stats. I've got low clinical experience from having to work full time on top of all my stuff and, while I know MD/PhD is what I want, I've been really worried I'll get nowhere because of it. I'm kind of in a similar place to where you were where I'm thinking about applying to PhD programs since I don't think I'll get into an MSTP. It's been very nerve-racking.1
u/Fun_Taro9685Congratulations!! Wishing you all the best. I am also applying to MD-phd programs this year. I would like to connect with you.1
u/AmbitionJaded3177Any advice for younger people starting their premed journey? Im a high school senior interested in doing an md-phd but im super lost about how to start and pace myself so hopefully I can have a successful application cycle like yours!1
u/Dyllidogliterally insane. Holy research hours1
u/CandyPossible6197🥳🥳 congrats!!1
u/Euphoric_Season_2475Can I dm?1
u/jaybsuaveChad1
u/Cadee9203This sankey making me feel insanely under prepared 😅1
u/Ok_Introduction8591congratulations!!! can i ask how your perspective to apply md-phd as someone in between phd only & md-phd was shaped by your clinical experiences?1
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24r/HFYThe Ones That Stayed SickDueProgrammer80233830%4875.9PRP knee treatment2026-03-06↗
commentercommentsentimentupvotes
u/Dramatic_Mixture_877As a person who has multiple sclerosis, thank you for this - it resonated deeply within me. I'm not on an immunosuppressant or B-cell depleter like a lot of my fellow MSers, so my immune system is at its full range. I get maybe two stomach bugs a decade; hubby gets one if it's within a hundred-mile radius. I tell people my immune system is just waiting for something to get close enough so it can pimp-slap it, lol. I really enjoyed this story!60
u/An_Insufferable_NEWTWe’ve reached the top of the mountain and we can’t climb any higher. Is this your post? Because it’s the peak29
u/Underhill42Good story, great finish. Though I kept rebelling against the misrepresented human immune system - one of us doesn't really understand how it works. It is not intelligent and doesn't meaningfully customize or refine designs - it generates massive numbers of random antibodies, filters out any that would attack your own body, and then releases the rest to see if anything works. And assuming something eventually works, stores a record of that particular design to make more of, and to try early on against future infections (at least until something like measles erases the records). The antibodies themselves though are NOT adaptive, and so wouldn't work against something that adapts against them - to adapt to an adapting disease, you need the entire adaptive system, not just the end products that worked in a particular situation.24
u/SanderleeAcademyMagnificent work. As I've seen from a few other threads, the argument over adaptive immune systems can get a bit heated. This story, regardless of "the science," really strikes a nerve, in a good way. I think this line, however, sums up the beauty of the story. "It's just what people do," she said. "When they're trying to be worth something." HFY, but not in a "humans scary, our tech is ridiculous, we be angry, we yeet rocks" way, but in a "no better friend" way. Marvelous. !n20
u/BasquerEvilOn of the best stories I've read on here... and way better researched then most11
u/rewt66dewd!N "What courage looks like when it has had time to think." Beautifully said.11
u/elfangoratnightI suspect that what Sevik had never encountered before is an entire species that collectively, as a gestalt entity, acts like a sort of immune system. The drive to self-sacrifice, as paradoxically destructive as it seems on the surface, is a way for the species to survive better in aggregate. In a way, Mara was just like a human version of a B-cell. Humanity, Fuck Yeah indeed! 🌟 💪 🎉9
u/DreamSofieI liked that, really well written, good pacing, with solid choices about what to reveal, and what to leave unsaid. I did feel quite curious about how your extraterrestrial civilisations made in out of their cradle, after evolving enough executive function to turn selfish, and suppress instincts beneficial to survival of species. But already leaving things to the imagination throughout the story, unsatisfied curiousity caused by the ending did not dent the story. Tfs.5
u/patient99There's a story from a while back called something like "strong constitution" or maybe just Constitution, that talks about the human immune system, kind of. The story makes several insinuations without ever coming out and saying it. A sort of summery: earth would be considered a plague planet, coming here would result in death by bacterial or viral infection, they don't directly say this though, and the procedure for plague planets is to purge them, humans never let anyone visit earth so the aliens don't know what it is and as such aren'tpart of the galacticcouncil since it would requiresomeone to visit their homeworld, humans are always seem wearing insulating suits, and the alien talking assumes it's because they're stuck up. He starts to peice things together when the human he's talking to has loads of equipment from alien races known to be violent and that don't often trade, ge chooses to indirectly ask about it.5
u/udsd007More, please‼️ Lovely premise. Mara, Sevik, and the Reshape all are excellent characters.5
u/Attamark!N Great story about some of the intangible things in the human condition when faced with a crisis. It deserves more recognition than it currently has!4
u/thefeckamIdoingMY kind of HFY… the kind I always tried to write. Find the thing that makes us special- and it can be small. For me it was things like humour, or attitude, or a myriad of other quirks of character. This was wonderful. Easily my favourite story in quite some time. Bravo wordsmith. Bravo.4
u/zachpkenyon"It's just what people do," she said. "When they're trying to be worth something." That's the one. That's what hits. Thank you3
u/rebelkittyInteresting story, would be a lot better if it didn't cut off before the end.3
u/westaussieheathenDamn good story, thank you.3
u/Light-Breeze-9805Superb... sublime... Touched every single cord ! Thank you for sharing3
u/PaxmcgeeBravo!3
u/Electronic_Mud5821Wonderful story, I really liked it. Why does my mind feel like it is a recruitment ad ? Damn the current state of the world, I am sorry.3
u/ReallyNotMichaelsMomI loved this and I cried. I think I needed it. Thank you.2
u/sirbinlid1That was truly excellent, thank you for sharing2
u/OneTrueSneaksThis is a genuinely beautiful story, and it had me trying to read through blurry vision through most of it. Thank you for writing it, and thank you for sharing it with the world.2
u/Giant_Acroyear!N2
u/HFYWaffle/u/DueProgrammer8023 has posted 1 other stories, including: [OC] First Time Writing Sci-Fi: Humanity Absolutely Terrifying from an Alien POV. This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.1
u/UpdateMeBotClick here to subscribe to u/DueProgrammer8023 and receive a message every time they post. Info Request Update Your Updates Feedback1
u/MorridiynA good story, but it looks like it got cut off1
u/Traveller1977cuts off halfway1
u/Neither-Animator3403The story seems to be cut short?1
u/Blue_Blurb_BoiI really like this! A lot of people don't realize how many essential functions in human bodies have approximately arose from foreign bacteria that worked its way into our cells and helped more than harmed. A very eye-opening take on life without adaptive immunity1
u/SomethingTouchesBack!N1
u/s4ndbend3r!N1
u/WSpinner!N1
u/SandsnakePrimeExquisite. Moving. Beautiful. I am in awe, Wordsmith.1
u/AutoModeratorThis was flaired as [OC-OneShot], which is for a stand-alone post not in the same universe as any of your other works, with no intention of being continued into a series. If you do decide to turn it into a series, this post should be reflaired as [OC-FirstOfSeries]. A description of the flairs and how to change yours is available in the Post Guildelines [OC-OneShot] For original, self post, story, audio, or artwork that you have created, that is self-contained within the post. Please help us transition to using the new flairs correctly. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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25r/HairtransplantUpdate : 8 months post-HT (4500 grafts)SavageSantaX2000%8575.0PRP knee treatment2026-03-08↗
commentercommentsentimentupvotes
u/Own-Violinist7606Holy shit u went from nearly completely bald to a dude with hair31
u/West_Description1217Fantastic result19
u/Significant-Air6079Congrats, that is an incredible result!11
u/taleofunknownGreat improvement, there will be some more growth (somewhere between 15-20%) up to the 12 month mark.6
u/Forever778This looks great. Which doctor and can I please ask the cost? Thank you.6
u/cleetusneckHuge change.5
u/ReapTheNorwoodYeah, longer would give it a better illusion of density, but honestly, another pass of 3,000 grafts will give you naturally dense coverage with any hair length.4
u/VibracoLooks great man3
u/700p3dWhat does Nizoral shampoo do?3
u/Wonderful-Bit6748Looks great, how much did it cost?3
u/Adorable_Ad_3013What doctor?3
u/Adorable_Ad_3013Can you share some post op pics?3
u/Salty-Garlic9471Considering where you started that's pretty amazing work. It'll only look better as it grows out more.3
u/ativerso1Excellent, happy for you man. Is there a picture of the crown and doner before ht3
u/pancho915Looking great king3
u/Intelligent-Rip-184What is the anti DHT shampoo? And also Nizoral shampoo?2
u/thewintersoldier711Any finastride side effects?2
u/NewUnicorn92Holy moly. Looks great. You look young now. This is giving me hope actually thank you man. Based on the photo it looks like you don't have much of a beard. Where were 4500 grafts extracted from ?2
u/Economy-Experience81amazing!2
u/Exciting_Sort_289Is this AI? Hot DAMN!!!!2
u/RkopelThis is an amazing result for eight months. The hairline looks natural and the density is coming in nicely. Many patients still see a bit more thickening between months 9 and 12.2
u/Reasonable_Double811looks fantastic, great result and very natural. You could also add SMP to fill in some of the spots that appear a little thin. It’s a great add-on to a hair transplant to make the hair look more full and dense.1
u/MBArone_0000Do you mind if I DM for details on the clinic? Amazing results, congrats!!1
u/1107759This looks fantastic, idk if this is dumb but will the transplant hairs continue to grow? Like in length like normal hair? I have been seeing a bunch of comments on this sub and updates and I’m a bit confused how that works in practice1
u/Imperial_Prince1996Wow man! Looking great! It looks natural! 😯1
u/SmoneyDGreat documentation and results. I wish you had post a picture of the donor area (back of head) prior to the transplant .. 4500 grafts is great. Was it all from the scalp donor ? Did they do any beard grafts ? I m sure the prp and the min/fin helps additionally1
u/SmoneyDThis is phenomenal work. From the looks of it, your donor area was standard and not excessively thick hair either. I really think the continued PRP injections made a difference (expensive) along with the meds. Thanks for sharing !!1
u/behappydontworry1Very nice!! Do you have to use products like minoxidil or blockers for it to grow or doesn’t it require maintenance1
u/Careful-Builder-9909At 8 months I don’t think you’d be seeing any new worth anymore because from here on the hair only just get pretty matured from baby hair to adult hair and you got awesome results compared to what you had before so just be happy with it and not seek perfection an Aldo not all grafts shrive the transplant which is another thing they don’t tell you when consulting, A second transplant is an option but I wouldn’t advise.1
u/Synotic__Honestly, i‘d consider getting some ghk-cu or even Glow (a mix of Ghk-Cu withBpc and Tb500 mix). Ghk for the better hair growth and the combo to actually reduce inflammation in the body which could hinder proper hair growth.1
u/Vladamir_pootinnThis is my biggest fear about getting a transplant… they sort your hair out but completely remove your face:(1
u/glowman777Look into an SMP tattoo and are you on a medicines?1
u/jerinjacob_uk👏 great result.1
u/8redDude that's great effect - btw can you shave short now? Or you need to be longer hair all the time? Does it look natural?1
u/Finance_Bro__Why would you take finasteride at all? You had no hair at the top, and all the transplanted hairs are DHT resistant, so you shouldn’t lose any of it. And the donor area is DHT resistant. It looks like your hair loss has stabilized.1
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
26r/TheRaceTo10Million$SLS (Deepest Due Diligence for SLS-009, Machine Learning Models and Results, an...Confident-Web-71181790%9674.9stem cell therapy2026-03-16↗
commentercommentsentimentupvotes
u/Even_Armadillo_634Me who trades on vibes: sounds good, buying more!57
u/cuntysometimesWow, as someone holding SLS due to conviction from galinpepimut-s (gps) research, thank you for this deep dive on Sls-009. Don’t have the time now but will def be back for a deep read. What are your thoughts on gps phase3 trial?26
u/ModelingDenver101SOB, I'M IN!!21
u/astroworldddBabe wake up new Confident Web DD just dropped17
u/The_Pixel_KnightSLS and IBRX were the first stocks I bought. Now my only 2 stocks. Just over 1000 shares in SLS. Im not exactly rich, so this could be life changing tbh. Wish I knew a ballpark timeline. Debating whether to invest more.15
u/Snoo-90236Ohh god Nooooooooo!!! Please for the love of god stop it with the DD. Everytime I see one of ur DD makes me wanna add some more. I already full ported this shit. And I got no money left bro. Im gotta sell my ass soon, or work extra behind Wendy's dumpster. Fukc11
u/Lowlander-b9Was hoping you would tackle SLS009. Thanks - look forward to reviewing.8
u/Consy98Was previously an SLS doubter, and never really had a large position but I’d never come across your posts but this has completely cleared any doubt I had. This post and research is incredible. Thank you so much. Opening a large position in the AM. Thanks again!8
u/Fragrant_Persimmon_8You dirty dog, I'm in! (For 1000 more shares)7
u/KirklandJoshLegend7
u/redditshelley1Amazing resource! Thanks for sharing!5
u/Dagobot78I’m up big on SLs… i sold 1000 shares last week and bought $7 options for Jan 20275
u/TestoWenzxRemindMe! 1 day5
u/currysoup19RemindMe! 365 days5
u/Consy98Was previously an SLS doubter, and never really had a large position but I’d never come across your posts but this has completely cleared any doubt I had. This post and research is incredible. Thank you so much. Opening a large position in the AM. Thanks again!4
u/Ambitious-Dark-6321OP maybe a stupid question but if the 80 event annoucemend still takes longer en longer does it still improve the hazard ratio or has is halted. Sorry for my English it is not my first language.4
u/bmarvin35I’ve been in since$4. Holding 7000 shares so far4
u/dirksqjawOverall, brilliant DD. Honestly one of the best I've seen in biotech. You lost me at the %99.99 thing though, that's a conviction statement disguised as math.The model is good enough to say "probability of success is meaningfully above the base rate for Phase 3 oncology trials". It is not good enough to compress the failure probability to 0.01%. Saying a blinded Phase 3 cancer trial has a 99.99% success rate isn't doing science, you've started writing fan fiction. Just to pump the brakes a little here, note that the control arm problem isn't addressed. What if VEN/AZA in 2024-2025 (the REGAL control arm's actual treatment era) produces 14-16 month median OS rather than the 6-8 month historical baseline? That would compress the hazard ratio dramatically even if GPS is genuinely extending survival. The cure-fraction model uses historical BAT priors. If the actual control arm is outperforming those priors, the HR prediction becomes unreliable. Don't get me wrong, I HOPE you are fully right, but I'm playing this like a typical biotech binary play. This is still a casino.4
u/PrettyStatistician29RemindMe! 1 year4
u/steadyeddy_10Thank you for the insight!3
u/ProfessionalDesk1914thanks, appreciate the sls dd and will read a few times. did notice you listed the market cap as 494m when it's roughly double at current share count and around ~1.16b fully diluted.3
u/mad_papooserI think if GPS pushes later into Q4 or Q1 of 2027, we should have early data on SLS009- I'd think it would lean more towards an all-cash deal vs cash plus CVRs.3
u/Just-Finance1426Amazing DD as usual, thanks confident-web. I have a couple questions though - why is SLS running a phase 2B trial for SLS009 instead of moving directly to a phase 3? And why did SLS set such an aggressive primary endpoint of HR < 0.63 for GPS? It seems like they would have achieved statistical significance with a smaller trial, or been able to conclude the trial with fewer events if they didn’t aim so high - I’ve heard that HR < 0.8 is generally sufficient to get approval.3
u/Roffles85Another one for me to read, thanks. Just out of interest what is the average cost of your shares, thats a huge investment…3
u/Accomplished_Way8964Thank you. My big fear at this point is the FDA decides the REGAL results are too good and ask them to run the trial again. Sounds preposterous, I know.3
u/Accurate_Pay_2242For the BO3
u/lndnmdnholy yaparoni3
u/lardarzAlright clever clogs, I'm in3
u/JoeAceJR20I have a DITM call for sls3
u/Intelligent_YoloerI’ve gone through all the DD and the comment threads on confident-web’s posts, and I still haven’t seen anyone clearly disprove the thesis with solid numbers. This man has exceptional talent in ML and statistics. This is still a binary play, and anything can happen. I will not go full port. I’m in with about 30% of my port right now, slowly adding in more shares with the gains from my other stocks.2
u/RaichuCakeOh please give us a $100 each share buyout2
u/My5t3ryLots of words and pictures. Im in ! Thanks OP2
u/carpool4445Solid DD as usual. Have a question not about science but about politics. If the war in the middle east drags on, what would happen if there were to be a global recession and wider stock market decline. The strait of Hormuz being shut down halts 20% of global oil, 33% of global fertilizer. How would this affect a buyout?2
u/Physical_Package_34020% of my portfolio now! Should I add more OP?2
u/SteveMcHeaveThanks for all of your hard work here. Is using 53 AML trial cohorts enough for statistically significant ML results? The sample size of patients also seems way too low for definitive phase 3 clearance. 99% chance of REGAL being a go seems a bit excessive.2
u/Consy98Was previously an SLS doubter, and never really had a large position but I’d never come across your posts but this has completely cleared any doubt I had. This post and research is incredible. Thank you so much. Opening a large position in the AM. Thanks again!2
u/1fortheroad24theshowMuch great data, much that does not make sense, at least to me. Several factual errors, herein, only to quibble, RPPR Vouchers, last 3 or 4 sold for $205M not $100. VINC VIP150 was the Most advanced CDK9 prior to Tambiciclib, its absent from your analysis. I Saw no discussion of the many fda apprved Kinase inhbitors. Tambiciclib P2B results for the AML-MR patients on optimal dose was not yet reached, so it will be longer than the 8.9 months you scaffold much of your data. In attempting to simplify, the OCT webcast has a very detailed analysis, from the Dr's trialing Tambiciclib, and underscores yours analysis, Tambiciclib will work better in Front Line Setting, than the refractory environment from the P2b, which ensures its approval, as the p2b data is already better than the current SOC AML-MR CPX-351. Thank you for the exceptional Due Diligence/2
u/BigPharmaSLSWHAT IS YOUR POSTING NAME ON STOCKTWITS?2
u/carpool4445Separate question pertaining to the REGAL timeline. In a separate thread, you argue that the models project it ending between October 26 - March 27 or even later. However I have heard it argued that REGAL is due “any day now”. This thread has run4theroses’s DD (https://www.reddit.com/r/sellasLifescience/comments/1rdp2sw/comment/o7qra8n/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button) and he argues that events are not linear and that REGAL results are imminent. Do you mind breaking down his claims and your own projected timeline more? I’m trying to resolve these competing arguments in my head but do not know enough science/stats to do so. also you might have to dig around in that comment section. A lot of comments were deleted so his DD is buried in a long comment chain1
u/carpool4445I am debating calls and thought I'd ask. $10 calls for Jan 2027 are a safe play yea? Because if REGAL doesn't end, the results from SLS-009 in Q4 will definitely spike the price above $10.1
u/Content-Resource5887Still early for a lot of these models, but they’re definitely worth keeping on the radar.1
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u/Upstairs-Zebra633And that matters
u/Reasonable_Cow3667slop-1
u/Leading_Form_8485Puts. Im dead serious-1
u/cyrustwoCan you PLEASE buy DRTS too? and ASTS? and RZLV?-1
u/SnooChickens561Always inverse Reddit — buying puts!!-1
u/Scary_Culture3768ummmmm I just farted-5
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
27r/jawsurgeryCan you forgive your parents?aragotos1870%8774.8PRP knee treatment2026-03-21↗
commentercommentsentimentupvotes
u/JadeFox_I was very young when my sister's orthodontist noticed my jaws were misaligned. I wasn't even a patient there. I was just pulled along by my mom when we were picking my sister up. The orthodontist was really worried about me, saying I might need to get jaw surgery when I'm older if I don't get it fixed now. I remember the concern on his face and the dismissiveness on my mom's face. I don't remember how old I was but it was definitely one of my earliest memories My mom laughed and said I would pay for it myself when I'm older I carried that idea of my health and me as a person wasn't worth helping throughout my formative years and into adulthood, where I grew up to be a very much fucked up person psychologically It's only been recently where, like a caged animal, I found my claws and fangs and finally took steps to pick myself up, but I'm walking on broken legs. I will never know who I could've been, what I could've done, if I were given the self-confidence people with normal jaws have After all those lost years and psychological harm done to me, I will never forgive my parents123
u/DarkThanos12That ortho treatment probably wouldn't have saved you. I have an underbite and I actually went through ortho treatment at age 9. All they did was camouflage orthodontics - extracted 4 teeth and pushed everything back, temporarily fixing my bite. NOW, my underbite is back. I now have 4 missing teeth I will never get back. And now I still have to do jaw surgery! I would’ve been better off without treatment. At least I would have all my teeth. These orthos actually do not know what they're doing. They don't even understand how their treatment impacts your airway or jaw development.70
u/ellieelaineHm, I'll give you a counter-point. Like you, my childhood dentist told my parents I needed orthodontic treatment. They wanted to give me the best and they weren't rich but they agreed. The orthodontist gave me an expander (good), braces (ok sure), and high-pull headgear (BAD). This was mid-90s, and headgear was already proven to do more harm than good by the late-80s. But he was an older dentist and not up-to-date. The headgear messed up my joints, shrank my maxilla, fucked up my bite, and distorted my face to the point that my muscles were always in spasm. I was in constant pain from my 20s onward. I started breathing through my mouth, which further affected my face. The part I'm mad about: they didn't get 2nd or 3rd opinions or treatment options, or take me to a real orthodontist. (This dentist also fucked up my sisters face by pulling 4 molars.) I had DJS in my early 30s, 9 years ago. I'm having a UJS revision next month. Wish me luck.43
u/damnthatsgudIt's hard for parents to make their child go through a heavy medical procedure unless their child's life is endangered. And they will most likely to pick a less invasive alternative if advised so by a medical professional. They most likely didn't think your underbite affected your life this much. Most people dont honestly. Power to all of us here for wanting to improve ourself in that aspect but folks with jaw discrepancy are out there and living their best and happy life without thinking their facial handicap.35
u/geekette1My mom told me that it was me that didn't want braces. At 9 years old!!! I can't forgive her if she puts the blame on my 9 years old self.23
u/RetrojawMy parents NEVER took me to any orthodontist at all and my dad still thinks my djs is unnecessary and essentially a plastic surgery and mocks it publicly in front of others. My mom was always half hearted and hasn’t really exactly been supportive pf the surgery, though my doctors and I have done ample explaining, but she did accompany me when needed. So I’m essentially in a similar kind of position to you, so I hope you believe when I say, I understand you. My solution to your question or our dilemma is this. Don’t let those begrudging thoughts crowd your mind constantly, nor allow your anger to do something stupid. We’re both young, maybe substantially or partially still connected and dependant on our family. This in NO WAY means, I’m asking you to forgive them. Now, I try to stay as calm as possible, maintain my distance and explain my side if any situation arises, but without too much effort. I’m just going to focus on my development, finding and building a career and probably slowly distance myself more and more as I can. As selfish or cold as this might sound, they did the same and don’t deserve any better and I’m not running a charity for the undeserved here. So try to enjoy your life as much as you can, because if you let this feeling of vengeance and anger dominate your mind, you’ll just be ruining your own fun and happiness.13
u/RedsqaNo. My palate was too small and I had malocclusion. My mother asked me when I was 11 if I wanted braces. I said no, because I was worried about looking funny at school. She asked me a couple times like it's my decision to make at that age. That was it. 20 years later, my jaws didn't develop properly, I have severe sleep apnea and need surgery. Aesthetically, I don't look bad, but from a health standpoint the effects have been dreadful. I resent her stupidity and naivety. She noticed the problem. She knew the solution. She was the adult. Why the fuck did she think it was her child's decision to make? Ah yes, children, known for their tendency to take the harder path and act in their long-term self interest. Whenever I complained, when I was a young adult, about not getting ortho earlier, she would reply "But you said you didn't want braces so...".13
u/crmsnprdAs a high schooler, my orthodontist wanted to do jaw surgery and my mom said no. Currently post-MARPE and on my second round of braces 30 years later navigating all the hoops to try and get it done. It’s super frustrating. Sending solidarity, OP.9
u/WhyamIhere977You can judge me if you want. While my sibling(the first child) got all the attention and doctors, orthodontist eye doctor and others.. and turned out to be a pretty good looking guy with a fully functional body, I(third child) didn't even get braces despite the fact I remember telling them my jaw is cracking bad while I was eating, I think I was around 10 maybe, of course I didn't know anything about the cause and consequences back then but still they did nothing. I can't lie sometimes I'm jealous of my brother even though it's not his fault Anyhow my upper protruding teeth somehow adjusted on their own some 5-6 years later but in return both my jaws are recessed which not only caused me problems medically but also socially, I could never do anything I wanted, could never talk to people I like because my underdeveloped, and imbalanced ugly face is unattractive and even now in my late 20s everywhere I go it's killing me mentally until I get surgery, and even then it will be too late to live how I always wanted. And they still don't care about my concern despite being the reason for it Some days I can't sleep thinking about all my wasted potential and what life I could have been living and for that alone I just cannot forgive them8
u/Fickle_Restaurant312I think we all have to be in that place of acceptance. I actually don’t think that they perform jaw surgeries on people until they are over 18-20 as the soft pallets and bones are still forming. So you got on top of it quickly. How are the results? Are you happy? I am sorry you had to go through this and those feelings. I have similar feelings to yours. My parents and I were told I needed this surgery I was terrified and didn’t want it to change my face etc I made the worst decision at 25 to have veneers put on my teeth from damage resulting from my bite. It was supposed to fix the undercrossbite that I had. It did cosmetically maybe slightly my teeth just landed on each other but the veneers were pretty but are failing and now I still need the surgery. Which I am still so terrified of I am now 44. I think those of us facing this issue of jaw surgery is so incredibly overwhelming. For us individually our families the finances the issues around insurance the fear about changing ones face and going under. It’s all a lot. I hope you get to a place where you can forgive your family 💕5
u/Character-Sort-5575I guess we have the same parents.5
u/0fficerD00fyMy other was very conscious about her mouth protruding out like a monkey. She did not want that for me so when I was a baby and bring breastfed she would forcefully push on my upper lip/upper jaw to stop my mouth from forming like hers. I do believe that this has contributed somewhat to my underbite. I had UJS last year and am now due for sinus surgery to fix my deviated septum and perforated septum. I've forgiven my mum, just upsetting to know that I could've avoided all this if my mum didn't brutalize me when I was a new born baby.5
u/United_Ad8618here's some reading material OP https://www.amazon.com/Adult-Children-Emotionally-Immature-Parents/dp/1626251703 https://www.amazon.com/Boundaries-Updated-Expanded-When-Control/dp/0310351804 https://www.amazon.com/No-Bad-Parts-Restoring-Wholeness/dp/1683646681 https://www.amazon.com/Attached-Science-Adult-Attachment-YouFind/dp/15854291395
u/Major_Hassle1I wouldn’t be too hard on parents. My parents really tried when I was a kid and I still had to get DJS. I’ve had orthodontic care multiple times growing up. I had braces when I was 12 years of old, 16 years old, and finally the past 4-5 years. Although I am upset with them that I got the genetics. I’m not made that they really did try to help even though it was really hard for them financially. You might have still been in my type of situation. You never know.5
u/pinksweets8I had treatment for my overbite as a child and I still needed jaw surgery as an adult4
u/FalseFail9027health neglect is very common, it just means ur parents didn't bond with you as much as they should have4
u/No-Evidence-416yeah i feel you. i told my mother i might need jaw surgery and get it checked. and she said i didn’t need all that, i am not a celebrity like taylor swift and i don’t need allat “bs” to enhance confidence or whatever. she was suggesting that i should accept defeat, find a partner and settle like that for the rest of my life 🫠 i slept with my grandparents growing up, not my parents nor did i have my own room. i have lip incompetence, i mouth breathed growing up, i had the milk bottle up till i was 11 yrs old, which caused a lot of misalignments in my jaw. they failed to notice that. i never learnt how to properly brush my teeth, i hated the texture of toothpaste and would go weeks on end without brushing my teeth. when i was 15 i begged for braces, got made fun of by own family members for having vampire teeth. i only got braces treatment at almost age 19. i feel like its just neglect at this point.4
u/SnooDoubts8688To be the devil's advocate, it may be difficult for parents to take their 8 year old only child through what they probably thought was a surgery. You probably looked like the cutest 8 year old bean in their eyes, they didn't see anything "wrong" with you functionally at the time. Maybe they distrusted the evaluation. And after that it just slipped their mind and never gave thought into it. My parents never took me to ortho, ever in my life. I had and still have very crooked teeth to this day, and had extremely painful jaw pain as an adult. I think a lot of our parents were still young adults at the time, and just simply failed to make the "right" decision. I could've wished for them to be more responsible about my dental health, but they took care of me in all other aspects of life. So, no harm done. What matters is that you took matters into your own hands at 21 and handled it. And what matters more is you went through it in your early 20's! I looked into ortho options past 30, and it required so many different surgeries that I gave up. Cheers4
u/ricey_is_my_lifeyI think there a lot more similar people to you than you realize. My parents delayed orthodontic treatment from about 10 years old to 15-16, and by that time traditional expanders were no longer a recommended way of treatment, so I ended up getting extractions and then camouflage orthodontics. Looking back if I was more informed that would have been the right time to start thinking of surgery. Anyways to answer the question, I can forgive them, but only because they see the byproduct of their actions. (Actually probably not, they probably have some weird excuse). But I see it as the same battle, we both share annoyances with some of my personal shortcomings in academics and life in general, which I can at least attribute to these developmental deficiencies, and allow me to spend less time comparing myself to others and their level of success because others do not share the same struggle. But yes, I do think of it as their responsibility; the choice to be uninformed, ignorant etc, when others around you already know to do it right.4
u/Entire_Garden3929Double jaw surgery isn’t really recommended for kids because your bones are still growing. So it’s a bigger risk than waiting until the time you did it For perspective I was later due to insurance bullshit. Placing your anger at your parents is dumb and you still got it done at a young age. You’ll look back and not even care. Live your life don’t hate your parents.4
u/Useful-Command903928, in the same boat. hugs3
u/mistyflanniganI finally had jaw surgery at age 25 when I could pay for it myself. My parents never paid for anything, including college. I couldn’t see the board in school and the nurse sent a letter to my parents recommending an eye exam. I got glasses at 18 when I paid myself. Some of us have parents who should have never been allowed to breed. You take care of yourself. Since they didn’t take care of you, maybe you won’t have to take care of them during their golden years.3
u/CanadianCutie77I have a similar story! Had my Mother put braces on me at a young age I wouldn’t have needed the surgery at 16 which I made the appointment for and I wouldn’t have had to endure at that childhood bullying.2
u/Glad_Bodybuilder6997I asked my dad about all of this and his claims the orthodontist never told him. I asked him for old files and he can’t find them. Soo… 🤷‍♀️ idk, but being mad about it won’t change the reality of my situation now and what I have to do2
u/KainMassadinWhen I was like 8 they took me to a dentist who said he needs treatment because “noone will like/love someone whose face looks like a shoe”. They didn’t defend me. At 11 I had very little discipline with brushing and flossing, plus wearing that face mask thing. I was a kid and had only bad experiences going to dentists at that point. They didn’t help me by being strict when they had to. I always tell myself that regretting and blaming is sooo easy, which is why I shouldn’t follow that path. They’ve been great and supportive in other aspects, but I’m amazed at how oblivious they are in seeing how the consequences have affected me (especially considering my dad had to go though the same DJS procedure!). Years of bullying and negative self perception have done a number on my mental, and now adult me has to clean up all the mess, I guess that’s just life.2
u/_neviesticksYes, but only after a lot of therapy. And I guess it's forgiveness in that I've let it go, but I'm not going to trust their opinions about anything moving forward. Frankly, the jaw stuff was just emblematic of their neglectful parenting. They were both emotionally immature and irresponsible parents.2
u/WillowRoutine4658I’m 28 and I get angry towards my parents every time I look in the mirror or look at my sisters. I have 3 sisters and they all got braces. I did not, despite needing it the most out of all of us. I had teeth extractions at age 10 because of crowding due to my recessed jaws. I had all 4 wisdom teeth removed at age 12 in hopes to again, make more room. At age 15 my parents were told I needed surgery. My parents turned around and said I was doing it on purpose. That I was sticking my lower jaw out because I wanted to be special. I had a horrible lisp and they would stick their jaws out and mock me with a fake lisp. It was so bad that I worked hard to compensate with different and unnatural tongue movements to prevent my lisp. I tried my hardest to suck my lower jaw inwards when my mouth was closed which just made my chin look longer. I never even got regular braces to correct my crooked teeth at least. My face was the main thing I was bullied for throughout my childhood. I got called so many names, the bullying felt like scenes straight out of a freaking movie. Kick me signs on my back, I got asked out as a joke by boys all the time. I got called crimson chin, quagmire, American dad. I got told I was the missing link. Asked if I was inbred. The harassment was so bad I wanted to kms many times and my parents didn’t give me a safe space from the bullying bc they continued it at home. I was quiet, read and studied all day, I was always in my room just to avoid being called names. I was so miserable that I skipped grades so I could graduate at age 16 and moved 15 hours away. Of course none of my minimum wage jobs paid enough to get good insurance that covered it but in a new city, people weren’t mean to me anymore. At age 24 I got a great job and amazing insurance, I’m now 28, took a few years to get things sorted, tests done and I finally got my braces on last year. My surgery is in September. My parents have since apologized and my dad has sent me a couple thousand to cover my out of pocket costs. The only reason they’ve apologized is because I post often on TikTok about my journey with the bullying, my braces and my upcoming surgery. I posted a lot about saving up for the surgery and my mom cried when she saw a video of me online crying about “how can I make myself prettier” and it was the first time she realized how deeply it had affected me. I frequently talked about how beautiful my sisters are and how I’m frequently forgotten when people talk about our family because of my looks. Sharing these things online where family and friends saw, my parents kind of realized how big of shits they were. My mom apologizes frequently and has already committed to flying out to help me recover from surgery and take care of my two kids (which btw yes I did find love and have kids and I’m actively monitoring both their dental health. They go to the dentist every 6 months despite both being under 3 years old!). My dad apologizes by sending me money. $500 a month and telling me to save it for surgery or to extend my time off from work. I do forgive them as their child but as a parent myself now, I get mad because I would never treat my kids like that. Ever.2
u/StephCurrySauceIt’s tough because for me my parents were told braces alone wouldn’t fix my issue as a child and that I needed a jaw surgery when I was older and to get me setup for when the time comes They were at the time new to the country and thought these were bad people trying to experiment on me and were scared and never told me when I got older until I (at the age of 29 trying to figure out what’s wrong with me) found out that I needed a jaw surgery and that my parents were told They’ve given me a beautiful childhood and their biggest fear is surgery and I get it, and even with me looking weird people still enjoyed being around me because I really had to put it all on my personality but I’m just wondering what could have been…2
u/schoolgirltrainwreckMy parents got a family friend to do my braces because they couldn’t afford it when I was a kid.. he botched it and was an overall freak who would laugh at me when I was in pain, and spew misogynistic rhetoric into my mouth while he worked. I’m now self-funding my jaw surgery at 29 years old! I try to be appreciative that my parents tried to get me what they genuinely thought was the best available treatment at the time despite their financial situation. I do wish they stood up for me when the orthodontist did things to make me uncomfortable, I wish they looked closer when he shrugged off things like my overbite getting worse. Life was already hard for them, and I think they wanted easy answers when it came to me. Such was the case for many things growing up. I get the temptation to blame my parents more about other things (even feeling sad that I have to spend my life battling dysmorphia about other physical traits I inherited from both of them) but it’s a dark path of resentment I try not to let myself go down.2
u/Hygienist_Bae[deleted]1
u/UnfairDream0945I can't forgive my parents1
u/whypiimy dad and I were told that my lower jaw needed correcting when I was 16 and first got braces and they said that could be looked into immediately. My dad declined because he thought I looked so much like him and now I'm 24 still with a bad jaw :( ur lucky urs was covered1
u/anonymous_opinionsI had braces, jaw surgery and relapsed. I don’t really blame my parents since no one back then was trained in or treating my rare disease. Jaw surgery was big in the 90s but became a lot less so later because insurance pays out peanuts and most of you wouldn’t have had severe functional issues as kids1
u/SpareAny4267I used to be upset at parents for not putting me on braces for my crooked teeth. As a child my teeth was so badly crooked that people made comments about it and stared at it with disgust. From other children (who most already started wearing braces at age 10-12) to my own narcisstic mother and her friends/relatives. I was too embarassed to smile and always tried to hide it with by forcing my lips shut and putting my hand in front of it, I also always shied away from conversations out of fear of exposing my teeth. I could barely look at my reflection in the mirror. Throughout my whole life my parents struggled financially so when I was younger I thought they couldn't afford it, when I was an adult I learned that braces would have been completely covered by insurance because I was a child. When I heard that information it made me more angry at their neglect, laziness and lack of parenting. When I was 23 years, I took to the step to get braces. In my case I had the luck that the crookedness in my teeth was so severe that my insurance covered it almost completely. I only had to pay a few hundred euro's for my braces. The orthodontist also told me in the beginning I had an overbite and gummy smile that I have to fix with jaw surgery, which I declined at the time. Now, 7 years later and 2 years off braces, and 8 teeth less, I'm doing research into getting jaw surgery. My teeth are straight but my smile looks off, my gummy smile got more gummier and I stopped wearing my retainers every single night because otherwise the space in my mouth will get too tight/small and I start getting breathing issues. Reading others people experiences with their orthodontic journey and then surgery, I'm in a way glad that I haven't gotten braces in my childhood. My issues are skeletal, so I would have needed the surgery regardless. I had camouflage orthodontics for my overbite -- and hearing how this kind of treatment has deformed and messed up other people's jaws when they were still a child and their was body was still growing and developing, I'm glad I had it done as an adult when my jaws were already done developing. For a long time I was sad about my teeth, when I was 18-19 I became part of a community where people didn't judge my crooked smile and there I slowly learned to let my guard down and smile freely with them. When I was 20 I left them, and yet again I came into in an environment with people who had negative remarks on my smile, one which was my BF at the time who pressured me into getting braces when I was 23. Do I forgive my parents? I do now. Whatever their reasons were, there is more to me than my teeth looking a certain way. I'm sad that I wasted my childhood years concealing my smile and being insecure. I'm pissed off at society's expectation of what is "normal" or what is "beautiful". Getting braces, having straight teeth -- these kind of thing is a modern invention. For thousands years people have lived with crooked/deformed teeth and jaws and accepted it. Now it's a norm that every person has this perfect, straight smile, as if it's self-evident. I am good as I am, crooked teeth or not and whether or not I'll get the jaw surgery, people can fuck off with their judgements :-)1
u/Traditional-Pear573I understand this so much. Sending you a dm1
u/Traditional-Pear573I can’t send you a dm.1
u/getcaughtstick2codeYep. Same.1
u/M345184Interesting because I’ve had braces since the 4th grade and I had them up until junior year of HS. When I first got braces, I didn’t have an underbite but when I had braces i started developing an underbite… (my dad has an underbite so it was probably genetic) there was really nothing they could do, when they first spotted it they did everything they could to minimize the growth but I still have an underbite, it’s not too noticeable though so I’m not that mad about it.1
u/HarleysDoubleMy parents said the dentist says all kids need braces and my teeth were straight enough.... real reason is they couldn't afford it. My husband is also bitter because his sister got braces and he didn't because he was a boy? Idk. The surgery is too invasive and expensive for his liking.1
u/Acceptable-Fishing61I’ve had a hard time. Couldn’t breathe through my nose my entire childhood (large adenoids)—> open class 2 bite w narrow palate. They only got one sibling out of 3 checked for adenoids but we all had the same problem. Went alone to my consultations, had upper jaw surgery at 18. Remember my mom forcing me to sit at the dinner table watching everyone eat while being wired shut for two weeks. She could also yell at me from another floor forgetting that I couldn’t answer. Now I’m 36, a dentist and going through an upper and lower jaw surgery to correct the first surgery that failed. I’m not going to tell her. (We are low contact)1
u/Tsunami-Square-XMy parents didn’t wanna “deal with” anything for me either. Ever. lol.1
u/WeWhoSurvivedNarcissists1
u/DependentArcher8393My parents never brought me to a dentist despite being free and no I don't forgive them, that would be a disservice to the adult teeth I've lost as a teenager.1
u/noahh1308I feel you because when I was like 10 my dad said he would make me wear braces but he never did (I and crooked teeth and a missing canine), later at like 14/15 we went to an orthodontist who said I needed jaw surgery because I was too severe and he said that I couldn’t get surgery because it gave him heartache thinking about bones getting cut. Around 3 years ago my dad changed his mind thanks to my older sister who told him this kind of deformity can cause health issues long term ( I already had head aches almost daily) and he said I could get jaw surgery if I wanted, I never had money for braces and in my case it was useless to get braces without jaw surgery, I had gave up at 14/15 already tbh. I sometimes do resent my parents like you do because they know I had some issues in my teeth already and later in the jaws, I saw my photos from my childhood and I always had an underbite I don’t know why they thought it looked normal. I just put up with my ugly teeth and jaws and I always avoided looking at myself in mirrors and photos.1
u/sunalee_I received orthodontic treatment and I still needed a genio, moreover for aesthetics I think I would have benefitted from double jaw surgery but my case is too mild now for me to get into the process. Now I’m thinking about facial implants.1
u/itsjoshtaylorSame, they neglected my scoliosis as well. It’s medical neglect.1
u/Fljl2121I was told I needed it At 9 but I don’t think my dad could of afforded it and I know they didn’t understand what I needed, after I had it done my grandma who mainly took care of me told me she had no idea how much it would help me1
u/Electrical_Day_5272Yea I am dealing with this dilemma. Didn’t get braces cause I couldn’t stop sucking my thumb til like the end of middle school. Kinda sad tbh cause I don’t know how to stop. I try not to hold anything against them because that’s not going to fix anything.1
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28r/alamedaBEWARE raw milk! New vendor at the farmer's marketrubysolomon1700%10174.8stem cell therapy2026-03-25↗
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u/AlamedaRaisedYes that's bad. I thought this was an Indian-owned business because of the name "Desi Milk." Turns out it's a white lady named Desiree, so Desi is a nickname. But on the company website it says she's been in the homes of hundreds of Desi families (South Asian families) through her arts, so she's actually co-opting the "desi milk" term from this community. "Desi milk" refers to milk from desi cows that are native to India, it does NOT mean raw milk. Most Indians do not drink raw milk, and most of those that do boil their milk first, due to not having access to pasteurization. This person is making it sound like a cultural thing and it's not. This needs to stop, both for public safety reasons and for cultural sensitivity reasons.141
u/ShoesietartThe level of stupid at the federal level is staggering.29
u/Abba_FiskbullarThis man has done heroic quantities of hard drugs, so he knows what's safe for us!26
u/contactdepartureDesiMilk posts this on her IG, but sees no irony in it... https://www.instagram.com/p/DCnG784ynmo/?hl=en Uhm...13
u/StracharysHere come the MAHA warriors who don’t understand about human breast milk vs cow milk or anything about farming practices. They will have statistics that don’t actually make sense, but they have done their research!13
u/Rolling_PugslyThe comments visible are nuts. Tin foil America. Edit to clarify: The comments in the IG photo praising RFK are nuts.10
u/Zealousideal_Help421I was there on Tuesday and overheard her saying to a customer that she likely won’t come back because the Alameda market is so slow and she’s a few hours away. Let’s hope.8
u/snickle99Yikes.7
u/heyitscoryIf you hang a sign that says "get a new clock" on the stopped clock, it's right all the time.7
u/LadyBrady66They take medical advice from someone in the Epstein files who did coke off a toilet seat. No surprise.5
u/Technical_Fix_706I wonder if these people believe they’re innately better informed and more knowledgeable than the highly educated & experienced in all fields of study & areas of expertise or just those associated with science & medicine? For instance, if their transmission starts slipping, do they run to the feed store for some horse dewormer or do they defer to an auto mechanic? If a grease fire starts in their toaster oven, do they sprinkle some peptides over it and douse it with raw milk? Are they the reason those tiny packets of desiccant have the phrase “DO NOT EAT” printed on both sides???4
u/Any_Administration17Yikes3
u/Kill_Bill_WillShe’s probably anti vax if she’s peddling raw milk too, yikes!3
u/rubysolomon<image> OH DEAR2
u/moth_candelabraThanks for the warning 🤢 these kooks are a public health hazard and should be treated accordingly.2
u/chrisfsDefinitely not good at sll1
u/gsanch9There’s a war on exercise everyone
u/Opening_Big4569this is not a place of free speech, has reddit always been cultish?
u/wwarrHow much raw pus is too much? In California and across the U.S., the legal limit for somatic cells (white blood cells, often referred to as pus) is a maximum of 750,000 cells per milliliter (mL) of raw cow's milk. This limit is enforced to manage mastitis, an infection, though typical herd milk often has much lower concentrations. What are Somatic Cells? They are predominantly white blood cells produced by the cow to fight infection or bacteria, particularly mastitis. Regulatory Standards: The FDA sets the limit at 750,000 cells/mL. If a bulk tank exceeds this, the milk cannot be sold for human consumption. California Specifics: California generally follows national regulatory standards, with the Milk and Dairy Food Safety Branch (MDFS) overseeing milk quality.-1
u/justid_177What do you mean by “beware”. Do they sell raw milk and claim that it’s actually not?  It is legal, and there is no reason for disparaging a legitimate business. You don’t want it raw, don’t buy it. Simple-7
u/Rich_Gap3429I actually bought some of this milk yesterday and it was delicious—definitely a high-quality product. At the end of the day, it’s a legal product in California and the beauty of a farmers market is that we get to choose what we buy. If you aren't comfortable with the risks or the vendor’s personal views, that’s fair—don't buy it. But I don't think we need to 'cancel’ a small business that’s following state regulations. Most people don't realize that many common foods like raw oysters or even bagged spinach actually carry a higher statistical risk of foodborne illness, yet we don't try to cancel the grocery stores that sell them. We’re all adults who can make our own informed decisions based on our own risk tolerance. If it's not for you, just move to the next stall!-15
u/Tommy2212222What is this? They’ve been selling raw milk at California farmer’s markets for as long as I’ve been going (2009). Shame RFK has spoiled the name of raw milk. In my experience it has been great, love the taste. Also just moved back from EU where it is relatively available. Not sure why you’re here rage baiting and disparaging a small business?-33
u/OhShitAnEliteOP you’re gonna wanna sit down when I tell you what you drank as an infant…-62
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29r/NatureofPredatorsAn Introduction to Terran Zoology - Chapter 61Still_Performance_392330%6474.7PRP knee treatment2026-03-31↗
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u/JulianSkiesOh my god What a perfect damned use of the mask at the end there, doctor. You went and pulled on every villain you've ever read about for that one haven't you XD Like holy crap, I didn't know you had some theater in you, old man, but you do!46
u/K_H007Well well well. Lamet is about to get an absolute earful, isn't she.39
u/Fexofanatic"demonstrable fowl", fuck i love this scotsman :D20
u/IAMA_dragon-AMAConsidering the steady calm MacEwan holds himself with, especially for his students, it's easy to forget that he has some understandably firm opinions about Venlil society.15
u/Apogee-500Ohhh i can’t wait for the next chapter14
u/Commercial-Gas-7718From one frying pan to another, this series keeps ramping up with every chapter!14
u/Minimum-Amphibian993Guess everyone is truly learning the feddies are hardly saints themselves. Wonder how long it will take for them to learn about the truth about the Arxur?12
u/Early_Maintenance605"...I hope everyone else is having a better time than me." Meanwhile, Having a Worse Time Than Her12
u/Jbowen0020Lamet must have googled the traditional dish of Scotland.... Lamet, youre about to become haggis11
u/SordidDreamsOh man, Lamet really stepped on a landmine by scaring away that voidpin, huh? Can't wait to see where this goes. Also, on a completely unrelated note, I can't help thinking about how the main trio would react to Jurassic Park. There have been multiple references to it in the story already, and with it being about bringing back extinct species and its message that trying to control nature is a bad idea, it seems like it would hammer home a lot of the points these biologists and an exterminator have been learning. You know, once they're acclimated and accustomed to seeing predators and depictions of violence.8
u/BbobsillypantsThe more I see of the Tolim Alejandro relationship, the more I think it's an irresponsible and in this case dangerous conflict of interest. But I suppose that's par for the course in NOP and it is cute so carry on.7
u/Super_Ankle_BiterOh I can't wait to see our good professor tearing up Lamet! Goddamnit, this is such a tease!7
u/Ablergo_El_EnfermoLamet a la pata siguiente: <image>6
u/Acceptable_Egg5560The Tolim and Alejandro scene was such a roller coaster. Tolim speaking about his part in how the facilities functioned and Alejandro doing their best to comfort their boyfriend. It is still only the start of healing, as he still has to find closure for what they participated in as well as recognizing that pain was still caused and those people deserve to work through their trauma too.6
u/NewguyS79The wait for the next chapters gonna be killer with a cliffhanger like that6
u/AromaticReporter308Oh, Bernard is feeling Haggis about it.5
u/Adorable-Ad5225OH NO, BERNARD SE ESTA VOLVIENDO SALVAJE!!!!! El capitulo que viene va a ser... UNA ANIMALADA!5
u/That-ExtensionUpdateMe3
u/abrachooNow this is a side of the professor we rarely see! I'm very interested in how this will go.3
u/Golde829oh boy whatever that conversation may entail, I would love to be a fly on the wall for that or in this case, a reader of the fic and then of course there's Milam's imho reasonable frustration at her parents I look forward to reading more take care of yourself, wordsmith [You have been gifted 100 Coins]2
u/IamhappilyconfusedGod damn it what a cliffhanger, can't wait!2
u/ChrisBattyI’m very much looking forwards to the conversation about unvarnished earth - I hope the doctor lets her have it with everything and it’s the whole next chair we going over everything. These conversations are often the highlights of a story when written well and I’m certain with such a high quality story it will be written well. Fantastic chapter as always.2
u/Aura_DastlerOh damn, guess even the most chill and patient guy has his limits haha2
u/NoOpportunity92I think you might have added an second second in the following sentence: there was a second equally large second floor underground.2
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30r/pennystocks$SLS (Deepest Due Diligence for SLS-009, Machine Learning Models and Results, an...Confident-Web-71181650%13174.7stem cell therapy2026-03-17↗
commentercommentsentimentupvotes
u/outdoors_life22You sir have made the longest Reddit post that I have ever and probably will ever see53
u/CHE-B5Pfoh you accomplished a lot but men, that is a truly a though, technical read haha42
u/Yung_CeejayGreat post! This is still my largest holding!23
u/Practical_Ad_5875I’ve full ported this, could be my biggest regret or biggest achievement19
u/Muted-Extension-852117
u/Regular_Hawk8513I only have 120 shares, but I'm looking forward to what they become.16
u/Urkel____grueThanks for another great DD post. I am a big believer in $sls and hold five-digit worth of shares (and buying more when I can). I see your posts a lot and follow you on Stocktwits. I really do appreciate them very much, and have read all of your posts. The only two things that give me pause about your posts: you clam to have 800k shares. You don’t owe use anything at all, but can you share proof of holdings? That’s an insane investment and you must have more conviction about this stock than of any stock you’ve ever held as a DVI with that amount riding on a single stock. Secondly, if the math shows 99.99% success rate for just REGAL, what aren’t investment firms pouring hundreds of millions into SLS if it’s so surefire? I know there’s a lot of interest from investment firms but there’s not $1b+ pouring in. It can’t possibly be so surefire as you make it out to be Thanks again - I don’t want my slight skepticism to outweigh the due diligence you’re sharing. It’s just, the amount of shilling from an account that only shills about a single stock raises flags for me. Cheers14
u/Playful_Criticism425What the helly.8
u/Used-Motor8283I'm balls deep in SLS8
u/Confident-Web-7118I am an SLS holder. I personally believe that SLS will have a premium with it essentially becoming an AML monopoly in the best case, with some platform optionality. My best guess would be somewhere in the 3-8 billion range. Perhaps higher if results are exceptional. But any ideas that SLS buyout will be in the 20 Billion+ range is folly. That would essentially make SLS worth around the same Moderna and BionTech, which have a platform proven for multiple indications. Sellas at best has two indications without further research/development. For a company to conduct many, perhaps dozens of clinical trials to truly create a platform, it would take billions of dollars in RnD. That is why they will offer a discounted price to future potential.6
u/Federal-Snow1914Really appreciate this and your other posts. I’m heavy into $SLS as well. A few questions to hep me understand your confidence for you since I can’t fully grasp all of your analysis: Have you ever been this confident in a stock and missed the mark? What percentage of your own portfolio is in $SLS? Are you betting the farm? Thanks again for sharing all of your work!5
u/MaxTrade84As someone who went through treatment for Leukemia (not AML) I appreciate the depth of research and am now a shareholder. Thanks!5
u/Tantpispourtoi5
u/ambassador3215
u/National_Major_9356Holy... this is impressive. I really apperciate your work. I can't even argue with what's been written, so I have to go in with a small position; I'll be watching this very closely.5
u/SavingsMortgage1972Frankly, I didn't read any of this so I have no idea if you overfit your models to hell but you convinced me to put 10 racks into this lets print money.5
u/Accurate_Pay_2242Holding for the BO4
u/altiifGod, I hope you’re right. I have 4400 shares at around $2 based on a random post I saw on Reddit. Definitely have made money but am holding on for the long haul. Amazing analysis and work that you put in - even if it doesn’t end up being correct. I admire the dedication and level of nerdiness.4
u/BehemothslayerTLDR, what’s the ticker that I’m buying??4
u/sterculese89I caaaaint reaaad4
u/PhebreGreat work, thank you3
u/BariBlueYou are a very intelligent person and I do my best to read all of your DDs to get even more of an understanding of what we own. With that being said I’m curious in what you do for a living if you don’t mind sharing or can give vague details. These models and over all DD is some of the best I’ve seen since being in the market the last 7-8 years. I know there is no such thing as a sure thing, but you’ve convinced me this is. If the 80th event occurs earlier than expected let’s say Q2 for example. Will the stock run on the great news or will there be no movement until a buyout is officially in discussion? Thanks for all the hard work you do and hope you can answer my questions if you have time.3
u/Desperate-Ring12😎😎3
u/Antonio-BamaoI am in. And I think you can publish one SCI paper using these meta-review data😊😁3
u/Admirable_Ad5134this is insane. props to you man. great work <33
u/Low-Childhood-748Its an incredible analyses, and u are to be congraulated for all the work you put into it. What was not factored in was the testimony of the leading enroller-of course that is not math, nevertheless its important. Dr. Tsirgiotis is convinced that the extended survival being seen is due to the GPS effect. He already explained that his patients were experiencing a better QQL, which makes sense since GPS lacks the cytopenias cuased by hypomethylating agents. Interestingly on the last KOL call, he pushed to study GPS in post transplant maintenance. An academic Hematologist would not push for this unless he was convinced of the effect. Moreover, 2 weeks ago we saw a linked in exchange between a Myeloma KOL and the CEO again where there was interest in evaluating GPS in the MM maintenance setting. My expertise was in KOL management and behavior, and I have a robust amount of shares, but what are the limitatons of the machine model? Could one argue that at the end of all this analyses, the model only has predicted the direction of the survival benefit???3
u/Ateyo94If regal fails we probably won’t get much out of sls900 right? When do you predict the 80th event will happen2
u/TheGoodSaladYou've mentioned a lot of positives, is there anything to be worried about/ anything that could throw this out? No matter how unlikely2
u/Ok-Rock7488I have thousands of shares. I want to buy more but I’m also building into another biotech that I believe will return good results. It’s about choice. Which do I top up. Probably going to let me sls position ride. Good luck everyone. Especially the patients.2
u/Interesting-Play-489Anyone who hasn’t seen the RD video from last fall and witnessed the giddy joy of Dr. Kahn as he talks about 009 should really do so.2
u/kroefRemindMe! 18 months2
u/[deleted]Well researched and thought out. Well done!2
u/Deep_Development3814Do you envision 3.50 could be an entry point?1
u/Low_Sheepherder7990My one and only critique of SLS… your buying a lotto ticket and waiting for a buyout. It will guarantee make you money… I have no doubt there. But in 5 weeks? 5 months? Two years? That unknown timetable and opportunity cost keeps me from going heavy on this one.1
u/Tom9274Firstly, thankyou for your efforts here. The time you've put into this is truly appreciated. Secondly do you have a Github repo to share? I feel I'd probably learn a lot going through your code.1
u/moreheart3Thank you so much!!! Are there any other pennystocks where you see a similar potential and evidence behind it? I‘d appreciate your insights🙏1
u/kroefRemindMe! 1 day1
u/shinigamislikapplesOh fudge that's deep1
u/DawctorMeNice DD again. You mention Keytruda as a potential trajectory, but not as a potential GPS partner. Merck and Sellas did the PT resistant ovarian trial, where merck supplied Keytruda for the trial. Do you think there's potential on Merck also being interested in (atleast) GPS? Biologically the PD1 + GPS combo seems like a good pair. Sorry if you've adressed this in your other posts or comments. I might have missed it, perhaps not.1
u/ExpertMycologist8149Alles gut aber schlussendlich ist es eine hochriskante Aktie. Das muss man eingestehen.1
u/Pretend-Comfort-2569Hey OP, I’m not biotech native in anyway and ran all your DD through Claude and this was the output. https://claude.ai/public/artifacts/91d890dc-e4cb-4d9a-8682-289b676cbbe3 Would appreciate your response to the following points that highlights skeptics. Thank you :)1
u/rockhao781Can you teach me how to build your ML models?1
u/PennyPumperDoes this submission fit our subreddit? If it does please upvote this comment. If it does not fit the subreddit please downvote this comment. I am a bot, and this comment was made automatically. Please contact us via modmail if you have any questions or concerns.
u/iplay4HimWell done. I have an off topic question. My biggest concern, legitimately, is AI. I truly believe AI is about to change everything in the next 12-36 months as it quickly passes human intelligence. If that does occur, not only will it have been a better investment than almost anything, but it could render most modern medicines obsolete as it creates more effective medicines overnight. Any thoughts? Just curious.
u/Better-Salad-1442The amount of these types of posts on this specific name is among the most bearish signals I’ve seen-3
u/Delancey1From 200k to penny, no thanks-7
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31r/ibsHow many diseases are masked by an IBS diagnosis?jmct162540%5374.5induced pluripotent stem cells2026-04-02↗
commentercommentsentimentupvotes
u/255chekai always thought of it as a catch-all. dont know what it is? call it irritable bowel - a wildly vague label ?negative103
u/Anonymous_AnomaliI actually don’t believe IBS is real. It’s all something else that isn’t easy to diagnose, so doctors give up.negative94
u/b00bieb00mAmazing how many real pathologies have historically been labeled as IBS. Good thing the modern approach is still a fodmap diet, antacids and a gentle suggestion that it’s anxiety. Wouldn’t want all that progress to complicate thingsnegative58
u/facialtwitchTo me it’s a symptom not a syndrome, there’s always a cause and the medical community need to delve deeper than simple testingnegative47
u/Tiazza-Silver“Oh your tests came back normal! Guess you just have IBS” shrugneutral22
u/SteambunnyI lovingly call IBS “I be shitting” because thats all we know. I had biopsies that came out clean but LOOK like Crohns on the scans, was in the most common spot for it and the doc even told me we were going to investigate it. But sometimes I wonder if he got a good punch of the wrong part of “cobblestone” part of it. That is the area he biopsied was normal next to an abnormal part. I also am being investigated for non radiological axial spondylarthritis which is autoimmune. It seems to go hand in hand with IBD. So idk makes sense to me but the docs dont know yetnegative21
u/PokketMowseI had 'IBS' all my life. While I was living in the UK, turns out they actually bother testing you for celiac disease. Guess who can't digest gluten but never had any doctors try to figure that out for 30+ years!negative15
u/Wildcard982Rubber stamped as ibs for decades. Eventually figured out that even tiny quantities of butter in bread takes a full month to heal from.negative13
u/bbtom78As I've gone to more doctors, I've found that newly diagnosed Endo and ADHD are likely the causes of my IBS. With recent treatment, life has changed for the better. ADHD linked to higher risk of irritable bowel syndrome, global study reveals https://share.google/d3rDt5sbSD6ZUmhGOpositive13
u/lugasamomI need to copy this into a document with checkboxes as we eliminate (pun intended) what I do NOT have, apparently.negative10
u/jmct16Posted here for more details: https://www.reddit.com/r/IBSResearch/comments/1s9q90w/how_many_diseases_are_masked_by_an_ibs_diagnosis/neutral9
u/Miss_J1801Thank you for this super interesting and elaborate post. As someone who got 'diagnosed' with ibs by my GP without basically any research, I feel seen.positive9
u/Pure_Temporary_6349This is correct, and it's even named correctly for the scenario of not knowing the cause. I'm a pediatrician. In medicine the convention is to use "syndrome" for a collection of symptoms and signs that happen together more often than in the general population and more often than by chance but without a clear underlying cause. Many conditions now known to be due to a single gene mutation were initially labeled as various genetic syndromes before the genes were identified. Sometimes a collection of findings labeled a syndrome turns out to be from only one common cause and sometimes it turns out to be several different causes with similar end results. But I notice my colleagues seem to forget what "syndrome" means. It's still useful sometimes to try treatments that help a statistically significant number of people with a given syndrome even if the cause is unknown to researchers. Causes can take much longer to figure out than treatments-- just because a treatment can help does not mean the absence of it caused the problem. So it's a concept that can help patients if applied correctly.positive7
u/GraciousPeacockMy father had to spend 10+ years with “IBS” before becoming hospitalized to near death to finally be investigated and finding out he has Crohn’s Disease. I am 2 years with IBS now, and I am grateful I am managing it somewhat okay because it may take a while to get diagnosed if I do have Crohn’s. I feel for anyone who struggles with this unknown illness known as IBSnegative4
u/RedditHelloMahThis post is really helpful! I hope we see more informative posts like this instead of those “I cured my IBS… here’s how: 1) I told myself to stop, 2) I ate healthy, 3) you should too.”positive4
u/FixedFun1I have BAD but for most doctors it was IBS. So I agree.negative3
u/magicpennyOne that was missed and falls under congenital/ anatomic would be Tortuous Colon. I have that and was diagnosed as IBS-C. Symptoms are pretty much exactly the same, for me at least. So, I definitely have a tortuous colon and may or may not have IBS-C.negative3
u/adorkable-lesbianI hate the term IBS. It took me eight years to get diagnosed with something else because IBS stuck and everyone thought it was in my head. I’ve been on medication for lupus (SLE) for a year now and my symptoms are vastly better!negative3
u/Marshmallow920Can I ask why you censored the word cancer? ?negative2
u/idontknowwhythisughI see mine 🙋🏼‍♀️ SIBO was a bitchnegative2
u/A-TutFascinating! I have LAL-D and have suffered with IBS-D all my life. My disease is so rare, I've never seen it mentioned in an article before that wasn't specifically about LAL-D as the main topic. Although I've known my diarrhea is probably from my disease, it's nice to see the article support it.positive2
u/BulkySquirrel1492neutral2
u/cccmegancccMine turned out to be Small Fiber Neuropathy (SFN) with autonomic and sensory involvement. But I also suffer with chronic pain and fatigue, so my symptoms are not limited to the GI system.negative1
u/Last-Barracuda-6808Wow that is an extensive list. I wish I had a good specialist who would test me for some of those.positive1
u/MsFuschiaI'm not reading all that because it's clearly AI, can no one write for themselves anymore? ?negative-4
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32r/30PlusSkinCareIs it just me, or does it feel like your face just decides to lose the battle wi...Angel-Downloading-772580%4774.2PRP knee treatment2026-03-06↗
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u/SuddenAvocadoTopicals wont fight gravity (much, tret helps). Its underlying structure. Exercise and staying a consistent weight are the best. I've seen great results form my NuFace Microcurrent and NEWA RF* devices, but they wont matter if you don't exercise and stay a consistent weight. *I saw instant results from NEWA but it died after the 5th use and I'm not replacing it right away.106
u/EAM44people don’t age in a gradual, linear manner, we age in bursts here and there. The two biggest bursts are at age 40 and 60, so brace yourself. I have NuFace, keep forgetting to use it…92
u/momob3rryExercise more than likely.64
u/GretchenWeiner2022Face massage is my number one (40F here). The muscles in your face will pull everything down. You don’t need a fancy technique you just need an oil based cleanser and clean hands. Rub on and spit that’s sore and after you’ve gotten all those spots, try massaging while smiling and then with your mouth open. I like to binge a show and just rub on my face for a while with my face steamer going and my vibration plate at my feet from time to time. You will find that after a while little grainy pieces will show up but if that happens don’t panic. It’s just sebaceous filaments that have been worked out. So really, the facial massage helps with lymph draining, sore muscles/sagging, and deep cleaning without stripping your skin.51
u/MsGeekStrength training is said to help boost your body’s collagen production, which helps with keeping skin firm. And it’s good for you anyways. Also if you’re a cis woman as you get older getting on hormone therapy or applying estrogen cream to the face can help.42
u/Titizen_KaneThis sub has a fucking bot problem to the extreme14
u/queenofyourheartSeconding everyone saying NuFace. I started using mine at 28-ish and I’m 34 now. originally for puffiness and a heavy brow, now for under chin bloat, slight droop on jaw, and same brow lift. You can use any conductive gel with it. I notice a difference when I do it 5-10 min a day for a month then every other day. Full honesty that I am using it for micro (no pun intended) changes that I’m sure most people don’t notice but I have to been on camera/calls for work and I see them.12
u/Careless_Mango_7948Yes tretinoin is proven to help stimulate collagen.12
u/Possible-Raccoon-146I can't say any products have truly worked for me, but exercise really helps. I fell off the strength training routine for a few weeks and I was spiraling about how old I was starting to look (I'm 37). In just two weeks of being back on my exercise routine, my face looks normal again. My skin is brighter and tighter.11
u/Complete_Put4822There's lots of natural things you can do like working out, drinking water, eating right. The only thing that will actually tighten your skin is Ultherapy or Thermage. Lasers help with skin texture. I just hate when there's so many promises from the skincare industry and no results. I will so though, using retinol and spf have been life changing for me.9
u/jenifaOHHHjennyFace yoga. Build up the muscles in your cheeks and neck8
u/HHOVqueenEndymed, Endymed Intensif, Morpheus8, Sofwave, Ultherapy Just be aware that not everyone is a candidate for all of these, and you need to see a skilled provider. You can mess up the fat in your face if the provider uses the wrong settings on the devices (which happens a lot with Morpheus8). More intense isn’t always better.7
u/Fearless_Annual_8416I’m 40 My weight only fluctuates between about 6lbs I weight train & run a little I noticed at about 37 I seemed to just age overnight Like everything had suddenly started to sink. Noticed on photos more than in the mirror This is natural ageing collagen loss. Skin looses its ability to hold itself up. Think of it as the scaffolding is collapsing. I have used tret for 10 years This has helped keep fine lines away - I don’t have any around my eyes or my forehead apart from the 11s I have Botox in 11s & under brow hair do brow lift. This has helped massively long term with skin quality- it doesn’t look dehydrated like some of girl friends who have fine lines now around eyes / forehead It’s helps with skin quality but can not lift the skin per say. At 39 I had 3 vials of sculptra over 3 sessions & I first noticed the benefits at the 3 month mark & it’s still improving as the weeks go by Will asses in June if I need a fourth Around my mouth, pre jowls & cheeks my skin is now lifted & firm but I still look like me. No added projection just youthful bounce to the touch. When I pinch the skin it’s feels thick not paper thin. I have since moved onto skinpen microneedling (had 3 so far) this is for overall skin texture improvement (I was oily so larger pores in between brows & across cheeks) I think whatever you choose it’s about stacking the right treatments for your skin concerns & knowing their limitations. I also treated my under eyes with 1 vial of redensity 2 filler at 35 year old - I still see the volume from it now. My injector said no more due to the risk of over filling I have moved onto under eyes boosters - had 4 Sunekos & will continue with maintenance treatments as this is definitely holding off lines & crepey skin in that area Another thing is really focusing in on hydration of the skin Gentle fragrance free skin products Oil cleanser Gentle hydrating 2nd step cleanser Tret & moisturizer Finding the ones that work for you & really keeping onto of it’s daily helps6
u/Difficult_Affect_452Copper peptides, tret, even otc retina have all firmed my shit up.5
u/Primary_Edge_602I was lucky enough to be given a free Sculptra treatment and it was honestly so good. It plumped everything up naturally and nicely. I’m currently pregnant at the moment, so I can’t have another treatment yet, but I will be when I’m able to do so. At the moment I’m just drinking my collagen (bovine) to get what I need.5
u/Shoddy_Challenge5253I do see a visible difference in how glowy my skin is when I’m taking my collagen peptides daily. Can’t speak on microcurrent or other devices or spa treatments but I do love my red light panel (mine has blue light for acne too, it works) and tretinoin. I see a noticeable difference when I’m using all at the same time and notice dullness when I stop or forget my routine for too long.5
u/vulylyvuLook into tazarotene3
u/Unfair_Finger5531I’ve used tretinoin and taz for 35 years, and I use peptides, egf, and vitamin c daily. I can definitely say the retinoids have effectively kept my skin wrinkle-free and line-free at age 51. They also keep my skin pretty firm. But the copper peptides and other peptides I use help a great deal. The vitamin c seems to contribute as well. Anti-aging is a multi product game. It isn’t just retinoids or peptides. It is ALL of the things: peptides, egf, antioxidants, retinoids, exfoliation, and vitamin c. All of these things need to be incorporated into the routine. I also think higher-strength retinoids are more effective as you age. For gravity, however, hormone replacement therapy can do a lot. Outside of that, surgery is the best solution. To get all the peptides and EGFs you need into your routine, try a multipeptide product. I love Bioheal prioderm lifting ampoule and emulsion. Both have a bunch of egf and peptides and antioxidants. And Hanskin collagen peptide ampoule is also very good.2
u/Weird_Squirrel_8382My sister told me radio frequency micro needling is her favorite thing short of a facelift. She's two years younger than I am but looks a good ten. She's also at a healthy weight.1
u/ReceptionWorking7312The only thing I saw results with was combo CoolPeel laser and Vivace RFM.1
u/sneh473I recommend you to watch dr idriss on youtube. She ll have all your answers1
u/orangedrinkmcdonaldsReally good laser treatments. Don’t pay for expensive skin creams - save for Fraxel or CO2 (for face and neck). A good laser routine + sunscreen + tret is way better than any half measures. Signed, your 45 yr old friend who got carded buying wine this week.1
u/Significant-Coast981I had overnight noticed my face was sagging and got Thermage laser treatment and after one session noticed lasting results! My double chin is gone and my fad looks like it did in my 20s! Can’t recommend this enough!1
u/sparkley_elfxGua sha will help drain your lymphs from lying down from sleeping
u/Few-Figure1167Following
u/AmberBlush9472Skincare, healthy bone density (hormones, supplements) and never ever get fat.
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33r/immortalistsDon't die from Alzheimer’s and other dementias. Here are the most scientifically...GarifalliaPapa2530%4473.9stem cell therapy2026-03-15↗
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u/whatrumimeansThis article can only have been written by men 🙈 The most important thing is missing - hormone replacement therapy in women.15
u/Keji70gsmStop catching Covid. Seriously, it has been shown again and again to impact brain and cardiovascular health, even if vaccinated (but vaccinated is better), even later variants. Viruses in general are not given enough respect for the cumulative damage they are causing, but covid is particularly nasty for how many body systems it impacts even if it feels like a milder infection.14
u/abrandissorry to burst anyone's hope but most dementias are idiopathic (no known significant cause) and no specific pattern of patients,sure a few cases do have a strong genetic component (Like Chris Hemsworth who has two copies of the APOE4 gene variant (one from each parent). Increasing his risk... The only sure thing we know about Dementia is they are age related (no one under 40 gets them) , so obviously some aging degradation of the cellular mechanism is ultimately the trigger, but the chain is complex and can be influenced by a wide variety of factors . The worst part of dementia is by the time your diagnosed it's too late, there's no effective treatment it's really one of those diseases that you can't do much about other than enjoy life until you can't..12
u/drafzulI advise APOE testing in all my patients with any family history to dementia, not a guarentee of course but prevention is always better and if they have any risk genetically they suddenly start taking advise, exactly like yours here, much more seriously3
u/FrewdWoadHow about that 40hz tone thing? The science on that is new but pretty promising, no?3
u/Ok-Highway-5247It’s too late for my aunt but I hope it never happens to anyone else in my family. Efhkaristo poli!2
u/doker0It's the fat -> no it's sugar -> no it's sport -> no it's stress -> forget it, it's genes...   The Science.2
u/Starwaverraver[removed]1
u/GarifalliaPapaBest scientific research: [1] Optimal Cardiovascular Health in Type 2 Diabetes May Reduce Dementia Risk https://newsroom.heart.org/news/optimal-cardiovascular-health-among-people-with-type-2-diabetes-may-offset-dementia-risk [2] The Mediterranean Diet and Its Role in Reducing Cognitive Decline and Dementia Risk https://pubmed.ncbi.nlm.nih.gov/39797935/ [3] Vitamin D, Homocysteine, and Omega-3 Levels Associated With Reduced Dementia Risk https://foodforthebrain.org/good-omega-3-homocysteine-vitamin-d-status-cuts-the-risk-of-dementia-to-a-quarter/ [4] Lifelong Cognitive Reserve and Its Role in Prolonging Disability-Free Survival https://pmc.ncbi.nlm.nih.gov/articles/PMC10084126/ [5] Impact of Loneliness and Social Isolation on Cognitive Aging https://pmc.ncbi.nlm.nih.gov/articles/PMC10357115/ [6] Effects of Heavy Metal Exposure on Brain Health and Neurodegeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC12625418/ [7] Effects of Intermittent Fasting on Cognitive Health and Brain Aging https://pmc.ncbi.nlm.nih.gov/articles/PMC10413426/ [8] Long-Term Exercise Training Improves Memory and Cognitive Function in Middle Age https://www.nature.com/articles/s41598-019-40040-8 [9] The Glymphatic System Clears Amyloid-β and Tau Proteins From the Human Brain https://www.nature.com/articles/s41467-026-68374-8 [10] Sauna Bathing and Its Potential Protective Effects Against Dementia https://pmc.ncbi.nlm.nih.gov/articles/PMC7560162/ [11] Aging Study Discussion on Cognitive Decline and Dementia Risk Factors https://academic.oup.com/ageing/article/46/2/245/2654230 [12] Study Results on Cognitive Aging and Dementia Risk Factors https://pmc.ncbi.nlm.nih.gov/articles/PMC10168460/ [13] Translating the Biology of Aging Into New Therapeutics for Alzheimer’s Disease (Senolytics) https://www.jpreventionalzheimer.com/7690-translating-the-biology-of-aging-into-new-therapeutics-for-alzheimers-disease-senolytics.html [14] Plasma Dilution Therapy Improves Cognition and Reduces Brain Aging Markers https://pmc.ncbi.nlm.nih.gov/articles/PMC8050203/ [15] Cyclic Overexpression of Yamanaka Factors in Neurons Reverses Age-Associated Brain Phenotypes https://pubmed.ncbi.nlm.nih.gov/38789561/ [16] Researchers Rejuvenate Brain Neurons Through Cellular Reprogramming https://web.ub.edu/en/web/actualitat/w/rejuvenate-brain-neurons [17] Sauna Bathing, Heat Shock Proteins, and Potential Reduction of Dementia Risk https://saunas.org/sauna-dementia-risk-hsp-hormesis/ [18] Young Plasma Rejuvenates Blood DNA Methylation Profiles Associated With Aging https://academic.oup.com/biomedgerontology/article/79/5/glae071/7618060 [19] Senolytic Therapies Targeting Aging Biology in Alzheimer’s Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC11103249/
u/TappindatfannyLots of saturated fat to avoid Alzheimer’s-2
u/Cat_Daddy37You left out the importance of lithium, and also a warning against the phytotoxins found in many leafy greens that can actually contribute to pro-aging and neuro-degeneration effects. Consuming certain leafy greens can form reactive oxygen species in the body which is linked to aging and neuro-degenerative conditions. Many of the phytotoxins in them block essential mineral or vitamin absorption, can turn into neurotoxins in the body such as cyanide, can cause inflammation which damage organs slowly over time, contribute to kidney stones due to high oxalate and therefore UTI's (while UTI's are positively correlated to dementia risk). Leafy greens seem more detrimental to human health than helpful it seems since you can get all the benefits of leafy greens from other foods minus the toxins. Such as meat, dairy, or other fruits and vegetables. And lithium is like the #1 promising dementia supplement recently, especially for alzheimers because it inhibits GSK-3 beta enzyme, which reduces tau and amyloid buildup. And it also increases "brain-derived neurotrophic factor" levels, increasing neurogenesis and neuroplasticity.-10
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34r/breastcancerLiving with stage IV metastatic breast cancerAggressive-Throat3032480%4673.9PRP knee treatment2026-03-18↗
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u/No-Inside7137I... am in awe of you. You are a bad ass. I'm sorry I have no dating advice but you are an INSPIRATION. And I'm So so sorry that nobody was hearing you for months! Sending you all the health, wealth, happiness and companionship your heart desires ✨80
u/spacefarce1301Your post made me want to go find every. single. person. who ignored or dismissed your pain and do violence to them. It's infuriating and heartbreaking. But I can't. So, I'll just send imprecatory prayers their way and send hugs and sincere best wishes to you. You deserve so much better.57
u/reffervescentWow, you've been through the wringer, OP. I'm so sorry all this has happened to you, but it sounds like you are not NOW kickin ass and takin names, so rock on, my friend! I'm a 16-year survivor of stage 3 ER+ BC, but I got it when I was in my 40s and married, so I can't help with dating advice. I hope others speak up, though. Also, have you tried posting in r/LivingWithMBC? ETA: ugh, had to correct my bad typo.22
u/timshel2000Wow - I don’t have any wise words to offer but I just wanted you to know I read every word you wrote, I hear you and I am so very very sorry you have had to go through this. It is so horribly unfair… and you were treated so very poorly. None of that should ever have happened. But also I’m so happy you’re seeing improvement now and man you are strong. Wishing you only good things and a clear path to NEAD. <312
u/MoganleafI joined a breast cancer support group at my treatment center and met a woman with stage 4 for 20 years. So why not build a life? They keep coming out with new drugs and nobody knows what the future holds. Your story is a tough one but I love that you shared and encouraged others not to give up! Powerful soul you are!12
u/marticcrnThis is like a master class in how much different healthcare can be if you’re 1) poor, 2) not white, 3) have difficult or vague symptoms, 4) are a woman, 5) don’t have insider information on how the system works. I’m so sorry healthcare is like this. Everything you said is true. I’m a nurse, I’ve seen it. My care is excellent, but I’m an old white nurse and I know people. My privilege is why I get this care. I wish I knew how to fix this. I know what to do. It’s just how to accomplish healthcare as a human right and not a commodity for profit. I’m so sorry. Fuck cancer. Fuck US healthcare.11
u/East-Sorbet5647Thank you for sharing your story. What a powerful story of perseverance. Reading this gave me hope. I’m glad you found good doctors but I’m so sorry that it took so long. As a healthcare provider myself I hate that the first part of your story happened but I know it does all too frequently. We could and should do so much better for people. You deserve to find a relationship that brings you joy!11
u/Working-Lemon1645I don't know how you're able to even make a coherent story out of what has happened to you, or how you've been able to keep from saying , "Fuck it" and burning down some buildings, but you have all of my respect. You've been through what even cancer survivors think of as hell, and it started with day one of a racist, sexist, inefficient bunch of providers and insurers who let you down. You deserved better and you still do. All I can do is say 🫂🫂🫂 and get on some vaginal estrogen if your ladyfish isn't ready for dating yet. And hylauronic acid moisturizer. The universe owes you a wonderful new love life, and I think it's damn well time for it to pay up now.10
u/slim_ebonyOne of the worst cases I’ve ever read. You need to write to a journalist or news station in your area. People need to know about your story9
u/panna__cottaYOU ARE AMAZING!!! What a story, keep at it girl. You are kicking ass 💪🏻8
u/Boring_Act1970As a nurse and fellow survivor, your story is infuriating. Our healthcare system is broken and racist and I’m so sorry you have had to endure this torture. Thank you for sharing your story, it is a reminder to us all just how damaging racial discrimination in healthcare can be. The pain management/diagnostic disparities, emergency room bias, and inferior quality of care cause medical mistrust, misdiagnoses, and so so much pain. I’m so sorry our system has failed you and so many others. The fact that this is still the standard treatment of Black patients is dehumanizing and disgusting. We can and must do better. I promise to show up and advocate for patients like you, always. Your determination and perseverance in the face of this is amazing. I’m happy to hear you’re feeling better! As someone who was diagnosed with stage 3 inflammatory and triple negative BC and beat it, I couldn’t agree more - just don’t give up. Keep pushing forward, it gets better. I absolutely think you should date, you deserve love. There’s a reason you’re still here - live it up, girl! Go get you some!! ;) Sending love, hugs, and healing energy to you, my sister! ❤️‍🩹7
u/HariharKaka-my aunt had stage IV. she lived 3 more years after diagnosis and honestly some of the best conversations we ever had were in that time one thing she did that I think about constantly.. she recorded voice messages for her kids. not like formal sit down stuff. just random voice notes on her phone. "hey baby its mom just thinking about u" type things. some were 10 seconds. some were 5 minutes her daughter plays them in the car sometimes. says it helps more than any photo ever could storycorps does structured recording sessions if u want that. her daughter also ended up using something called pantio later.. it built a voice clone from all those recordings. she said the first time she heard it she just sat on the floor and cried for an hour. but now she plays it for her kids even just hitting record on ur phone while u talk is enough tho. the content doesnt matter as much as the sound of u6
u/fatimaa3I don’t have advice in the dating department but I want to say I’m so sorry for all that you’ve gone through and how much the healthcare system neglected you. It’s truly a shame. Wishing you ease.6
u/new2theparteeI think someone would be very lucky to land a woman like you. A strong person of good character would love being with you. You just have to find each other. It’s a crappy thing that you had to go thru all of this to be an inspiration to us all. I hope you will get out and give Mr Right a chance to find you. You deserve all the happiness and good things life has to offer6
u/Nervous-Many8176Hard to imagine what you’ve been through. Go ahead and date. No one is promised tomorrow, as you know, you can start the day healthy, you can start dating healthy, but any time either one of you can be hit with a life event. It is the nature of reality. One good moment, hour or day at a time. Same with dating, stay in the moment, neither of you can predict the future. And, everyone, btw, bc survivor or not, has a terminal disease. Take care of you!5
u/No_Maintenance2488I am so angry for you!! Keep telling your story. We all have to tell our stories. The stories I have heard pre diagnosis helped me tremendously when I was diagnosed. Someone said to me when I was diagnosed “You will have better days” and I hung on to that. It’s true.5
u/Infinite_Locksmith19I understand everything you're going through. This is my 3rd cancer diagnosis stage 4. I too was denied meds and looked at as a junkie bc of the color of my skin. Even the Caucasian lady spoke up for me and told the dr that wasn't fair. I also had to wait months so around Oct 2021 I knew I had cancer but had to wait til Jan to get a mammogram n biopsy to get a diagnosis. Jan 2022 stage 3 triple negative bc, chemo, lumpectomy , radiation. I kept telling my drs in 2023 my cancer was back but they said inhad ptsd and was paranoid. Ffwd Jan 2025 same cancer stage 3 so July 2025 I did a double mastectomy diep flap with tummy tuck. 2 months later I'm telln the drs again the cancer is back but I'm stuck in the hospital Aug for 3wks bc the port gave me dvt in my jugular vein, shoulder n every vein in my left arm. I got out last wk of Aug n went back Sept 5 for 2wks bc now the dvt turned into pulmonary embolisms. I finally got out and by the time I settled it was Jan 2026 and boom I had a ultrasound n petscan that showed stage 4. 😓 It's like in 2022 I said I have cancer n I seen my bf once a month then he disappeared n I was with him for years . Stayed single a yr then 2023 I got with my new man and soon as I was diagnosed he did the same, disappeared n started being distant. Be careful if you want to find someone. Have talks with them and make sure theyre for u so u don't fall into a deep depression. God is my strength through this. Praying for all warriors.5
u/IamRick_DeckardI am so sorry this all happened to you. It's unjust. I just wanted to say that my doc was talking about Enhertu and was saying it is so good that they are wondering if they can cure stage 4 Her2+. I hope that gives you some hope that now that your cocktail is figured out it will continue to shrink the tumors. My advice for dating is just to be honest. The other person can make their own decisions, and for the short term you just want to meet people, right? No real pressure. Big big hugs.5
u/triblogcarolOh my what a story. Thanks for sharing. I'm sorry you had to go thru all that and at such a young age. Fuck cancer. Hugs for you 🙏4
u/Adventurous-Cheek171This. Alllllll of this. I honestly don't think I could relate any more to another human being. Thank you for being so open and vulnerable and honest about this. It really is such a testament of how you are as a person. And I value you. I'm in same boat as you. I am here for you whenever you need.4
u/Like-whoa8108if i'm being honest, out of fear, i usually don't read the stage iv posts - but i read yours for someone reason and im so glad that i did. i can tell that you have such a radiant light about you and even though i have no advice for dating, i really hope that all the good in the world finds you 🩷🩷4
u/kelkelyEveryone deserves love. No matter how long they live. Its not YOUR job to determine what someone else will risk. Loving anyone comes with risk. Loving someone that might not live till very old age js a risk...but you dont get to decide for people. Put yourself out there. You might be the love of someone's life! Sorry you had the most horrendous experience....I can barely fathom the past year or so you have had. Shameful on the medico community. I cant imagine the pain you've been in. Chin up.. style that fragile hair and go grab some joy...you sure deserve it. As far as the parents. View it as the bonus time you get to make memories with them. As someone what lost her only parent 19 months ago...id jump at the chance to spend a few years with my dad again. My heart goes out to you. What a ride it's been. May the path forward be much smoother.3
u/chantillylace9I am a lawyer and I’m just so incredibly angry for you. I’m so sorry and I’ve experienced a small amount of what you’ve experienced and it’s horrible. But you have basically gone through every single horrible thing that’s imaginable. And so young. I’m so sorry.3
u/IngenuityFar5111Dude, if you can comeback from this hell, you can surely have kids. We have seen stage 4 women getting pregnant or getting surrogacy. Also, you have shown immense strength and I want you to live long enough to tell this story at your 50th and 75th birthday in schools for inspiration.3
u/ThymeLordessOh my gd girl you are amazing for keeping on going with such strength after all you have been through! Let’s keep fighting stage 4 and kick its ass!3
u/AgreeableBusiness435What you've been through from the first urgent care dismissal to the misdiagnosis to the spinal fractures to C. diff to nearly 100lbs lost, and you're still here at almost 30, walking without a cane, with tumors shrinking on Enhertu. That is not a small thing. The part about one full 24 hours without vomiting giving you a reason to keep going hit hard. That's what survival actually looks like, not inspiration, just one small thing that cracks the door open slightly. On dating: you are not a burden for wanting love and companionship. You are a 29 year old woman who has been through more than most people will face in a lifetime and you still want to connect with people. That's not guilt-worthy, that's human. A few honest thoughts from people who've navigated this: You don't have to disclose everything immediately. Getting to know someone, figuring out if they're worth your time and energy, comes before the full conversation about your diagnosis. You get to decide when that conversation happens. The right person will not run. And the people who do run were never going to be able to show up for you anyway, so the diagnosis becomes a filter rather than a barrier. The social anxiety after isolation is real and worth addressing with someone who specializes in it, not because anything is wrong with you but because you used to be a social butterfly and that person is still in there. You deserve to be loved.3
u/SendBoobJobFundsPosts like yours are inspiring for me to get back to being a therapist again. I have been trying to explain to all of my docs about my lifelong medical system PTSD. And sometimes I gaslight myself thinking “this is not a big thing, hardly anyone has this particular trauma” but reading your story reminds me that some people very much do have this trauma.3
u/derrymaineMy god, girl. You are just…you are amazing. I wish I had true suggestions but I am in awe of all that you have been through and what you continue to endure.2
u/Additional_Shirt_509So so sorry this happened to you. Best wishes for your journey going forwards x2
u/Metal_WaterWoodOh my gosh you are a warrior goddess! To come through what you have dealt with and have the levity and be interested in dating should make all men swoon. There is a Mets Sub, hoping someone can share a link? You deserve all the best doctors, support, information/virtual hugs that exist in this world. My prayers and heart are with you OP.2
u/Lizzy43645You are amazing! What a crazy and terrible journey you’ve had to go on but complete an totally respect to you for kicking cancers ass and in keeping up the fight. Best of luck on everything and may your journey in life be peaceful and happy 💕💕💕2
u/tyrannosaurus_hex_well i was having a bad night and this snapped me tf out of it. I'm so sorry this happened to you. you're an extraordinary person and deserve to have romance and love in your life-- and options and possibilities and dreams and hopes and fears that come with that. I also struggle with imagining a future with regard to dating, but no one knows what the future holds, and many people live very long lives with MBC as a chronic but manageable condition. there is a lot more to your story <32
u/JustAd330So sorry you had to endure months of negligence but glad you kept advocating for yourself and are at a better place now. Keep being the bad ass that you are and persevere through this and good luck in the dating world! Hope you find your person that will support and stand by your side through this journey.2
u/canuck_mojoI am so happy you are getting better and I'm sending you big hugs from Toronto. My cancer was not properly diagnosed for 4 years, which has caused me so many issues, but you have been through hell. We see you, we are rooting for you. xoxo.2
u/StenoDThank you for sharing- you are freaking amazing 🤩 I bow down to you!2
u/KkhanpungtofuYou’re shining a light on the tragically flawed US healthcare system, and I am so sorry this happened to you. And we are so glad you’re here to tell the story and encourage others. Bless you.1
u/prettykittychatWow. I’m so glad you’re still here. I’m just floored that the medical folks all dropped the ball so badly at first. I’m glad you’re feeling better.1
u/N3RDBUSTERThank you for sharing. I have just started treatment for stage 4 in my bones and liver. I have been so sick for the past month and truthfully I think of throwing in the towel or ending every day. While I never got the horrible run around you did I’m carry a lot of anger with my team as I never received scans the two years I was symptomless. What the fuck!? It’s so hard OP, thank you for bringing some light for us who can’t see much hope.1
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35r/EndoAfter 20+ years of 8-9/10 pain every month and no solution besides barely effect...FJRabbit1810%7073.9PRP knee treatment2026-03-12↗
commentercommentsentimentupvotes
u/buyableblahYeah I was gonna suggest MCAS since you have POTS and hEDS. It’s wild isn’t it? Have you tried a low histamine diet?39
u/kgirl244Have you ever tried midol complete? The antihistamine in it makes me feel incredible on my period. If I don’t take it, I’m doubled down feeling like death as well. I have a lot of MCAS symptoms but didn’t qualify for the full blown diagnosis21
u/juneberry19I started taking cetirizine hydrochloride 10 mg last month, and the period I just had was SO much better than the last few. I had no diarrhea, no intense anxiety right before my period, AND i only took like 400 mg of ibuprofen each day. I’ve decided to just take it every day for the next couple of months (since I get seasonal allergies in the spring anyways). I’m honestly so shocked that an antihistamine would make such a difference. I’ve only been diagnosed with endo but nothing like MCAS, but suspect I have some other reactive immune disorder.12
u/kirtkneeWow. This is would be so nice! I’ve been taking a daily antihistamine for over a decade and do occasionally need a second during luteal or menstrual since I feel extra skin crawly. Wish it would help my cramps 😭. But I’m glad you’ve found some relief!11
u/FlashyResearcher18Thank you for your post! I’m not formally diagnosed but I show many symptoms that the doctor dismissed as work stress. I had a similar experience. I took one bilastin pill and a DAO supplement and overnight my period flu disappeared. There really is a link between estrogen/histamine but given the low status women’s health has been given we don’t even know!9
u/These-Foundation6815You’ve just given me a realisation too. I had excision surgery Dec 24 and symptoms started coming back June 25. I’d had weird mobility issues and stuff I’m putting down to massive vitamin deficiencies since about the April, plus the start of what I think is probs MCAS symptoms around same time. But the endo pain was manageable up until November when it hit me like a ton of bricks. I stopped taking daily antihistamines in October. I wonder if that might have something to do with how the pain went from 1/10 to 5/10 to 9/10 in the space of three months. Huh.9
u/keystI take Pepcid AC as an H2 blocker and when I stop I flare up. I figured this all out on my own.7
u/vienibenmioYeah, Tylenol PM has really helped with my pain in the past. My brother-in-law is a doctor and says that benadryl reduces inflammation5
u/Tallchick8Just a PSA in case anyone is thinking of trying antihistamines. They really do not mix well with alcohol. I remember when I was in my early twenties and had gone to Vegas and was completely clogged up with allergies and took an antihistamine and drank a glass of champagne at brunch then had to sleep in the hotel for the next 6 hours. Definitely look up other drug interactions also but this one's a major one. Really glad that you found something that's helpful. OP.5
u/ParsleyImpressive507I think I’ve got histamine issues at play. Will come back and read you post more thoroughly!3
u/calilicahi! can you tell a bit more about your IBS symptoms? were they mostly diarrhea or constipation-based? asking cause I suffer from persistent constipation for YEARS and have tried every GI test on Earth but only get normal results 🫠2
u/Sad-Gold-6656With all of your comorbidities, I would make sure to be checked for May Thruners and Nutcracker. Also, people with hypermobility sometimes have pelvic floor dysfunction and not Endo at all. Look into stomach compression like Jelly Band. Have you gotten scans for compressions? P.S. People with your comorbidities get surgery all the time. You just have to let your doctor know and make sure the anesthesiologist is knowledgeable on your comorbidities. Lastly, I know diet changes suck. I'm also Autistic. But looking at the low histamine diet and making small changes can help. For example, I cut out onion, garlic, tomatos, wine, beer, and try to limit dairy. But I can't give up the dairy!! Good luck ❤️2
u/pinball_lifeEndo tissue creates estrogen on its own, then histamine and estrogen create a potent feedback cycle with each other. Have you been recommended mast cell stabilizers to reduce the release of histamine in the first place? Traditional anti-histamines are generally receptor blockers and not as effective at reducing the load and disrupting the cycle.2
u/hemkershTake some pepcid too. Combo of H1 and H2 blockers is helpful2
u/cosmolityI just wrote this comment so I'll post it here for anyone who might stumble upon it.  I'll add that anti histamines, specifically desloratadine, was the only thing to help with my pain also along with the following:  I have suspected umbillical endo and it was as only by fluke that I found something that works for me. My pain flares happen when I deviate from the diet I'm on to control another set of issues I also have-including salicyate and histamine intolerance and sjogrens symptoms-severe dry eyes and dry mouth, brain fog and fatigue.  It was only by fluke to try to treat the, at the time mild, dry eyes when I took seal oil omegas that my dryness went away. When I stopped the omegas, within days my hair started falling out. The dry eye and mouth was unbearable. Insatiable thirst. No eye drops helped. My tongue started to dessicate. I thought I would have to quit work because I couldn't think at all the brain fog was intense and unrelenting. I started the seal oil and the symptoms started fading and in a few weeks were almost gone. I have tried to come off the seal oil several times with the same result-it comes back with a vengeance.  It was during one of those times that I stopped to see if my body could handle it that I started getting umbillical endometriosis symptoms. Starting them again staved them off. I began the diet of low salicyate, low histamine, no sugar, no dairy and low gluten and for six months I felt normal. When I stopped them again is when all hell broke loose and I had stabbing needle like pain, burning across my entire abdomen, a lightning rod like pain right through my entire abdomen, pulling and tethered sensations around the navel and to the right. Sharp pain during BM. I had daily unrelenting pain for two months, even though I started the seal oil after only five days off it. Gradually it went away. Gluten triggers it also, certain types of wheat. I still have very very mild pain and not every day like it was then.  I have theories about what's happening to me because I'm driven to understand the mechanisms behind it. I am a carrier of pathogenic e coli from food poisoning and I had COVID before the other symptoms amplified. It's suspected by doctors that the EPEC and COVID, perhaps long COVID, have contributed to this and now I think there is some sort of MAST cell mediated histamine and salicylate dysregulation/ COX-1 pathway dysfunction that the seal oil somehow down regulates because of the strong combination of DPA, EPA and DHA. Most other omegas only have trace amounts of DPA, so I think this is why the others didn't work for me. I also have anti vinculin autoimmunity from the food poisoning. I think we underestimate the level of inflammation that can happen when a certain type of bacteria not only damages the mucousal and epithelial lining, but also takes hold and produces continuous toxins and prevents other bacteria from breaking down histamine and other chemicals like they should be. Some of these bacterial colonies may also be producing too much histamine hence they add to a system already overloaded with inflammation. Once the loop begins, like with endo, then it may be a difficult process to interrupt, especially if the colonies arent eradicated and continuing growing and damaging.  Just sharing my experience. It's anecdotal but if it can help even one other person then this worth it.2
u/calilicaOh, just one last question: are you diagnosed with endometriosis or just suspected it?1
u/FaithfulButterfly91So it just takes the pain away but doesn’t lighten your period right? I have a prescription for cetirizine. I might just have to try it. My doc just gave me a prescription for tranexamic acid for bleeding too. Hopefully I can take them together.1
u/cozycornerI have laparoscopic confirmed endometriosis and got a hEDS and fibro diagnosis about 4 years ago. Early menopausal about that time too. Now I’m 49 and went to get an allergy test since I got alpha gal (unrelated to the other stuff) and it turns out I had a response to almost everything and I’m taking shots. It all has to be related. And I feel better the day as I take antihistamine too!1
u/IcyFuel5368So you’re just taking loratadine?1
u/puppycatbuggedi started cetirizine last month when i started to feel what I usually call the period flu (super heavy body, lethargic, massive jaw and head pain and swollen nodes, etc.) and within a few hours of taking it I didn’t feel 100%, but it was definitely a massive improvement. in january i was SO sick, like just a whole mucus production factory and i wish i had known to try it then. just like i wish doctors would even suggest this to us as an option so we don’t have to suffer without trying anything.1
u/Wooden-Discipline444What’s the histamine called ?1
u/donkeyvoteadickI have allergies so take antihistamines regularly, can't say they've ever helped my pain but it would be great if they did haha1
u/nmw84pdxI wish antihistamines would help mine! Lol. I’m allergic to… well, fricken everything. I’ve been on allergy meds nearly my whole life, so I hope someone would have noticed a difference in inflammation at some point or another. Although I didn’t get endo dx until I was 37 and it was during my hysterectomy, so… I’m so glad you found easy (ish, you know what I mean) relief! I hope it continues to improve 💛1
u/Secure-Remote8439POTS and Mast Cell Activation Syndrome are a bit related. (I just learned this because I was researching POTS after seeing this post)1
u/rollingdeepdelphiSome antihistamines can kill interleukin pain signalling I think read somewhere and so halt somd inflammatory pathways. You might be a good candidate for the melatonin protocol and the ginger protocol too if this worked!!1
u/Opal-Planchette018Yes! I had a friend tell me a Pepcid a day keeps the crazies away! She had read somewhere that antihistamines could help with her horrible periods and thought she'd give it a try. It worked so well for her I also wanted to give it a shot but it seems to have reactions to some meds I'm on. Glad it worked for you as well! I think, since it doesnt really hurt you (confirmed by my friend's doctor) anyone who can should take a Pepcid a day. **Pepcid brand only, per my friend the store bought stuff does not work the same 🤷🏻‍♀️1
u/Possible-List8078Living with chronic pain for years is exhausting 😔 sometimes looking into new treatments or clinical trials can open up options that aren't widely available yet. I heard Care Health might have some helpful info that might help you .1
u/Inside_Prize9932Try CASTOR OIL in the navel. My story I started having bad periods where I'd swell up like I was 9 months pregnant all the way to ribs, my stomach was tender to touch, it hurt/felt like it was all swollen when I had a bowel movement, have to be under heating pad for first 2 days just absolute miserable. Had a ultrasound done bc thot I had endo, results came back normal. I was diagnosed with PCOS 10yrs ago. I'm 34 now. Doctors only solution was birth control pills, which I refuse to take, so I took matters into my own hands an tried castor oil. Let me tell u it works, I have to make sure I'm taking it everyday especially b4 period starts, I have no bloating, I can eat whatever, I do still have like ghost cramps but nothin that needs ibuprofen. I put oil in my navel an a small swipe across waist line every night (sleep in a top u dnt mine gettin stained) start off small bc it could disrupt ur bowel movements. I feel like maybe I have endo in my belly area but I don't wanna have surgery to find out lol hope this helps some. I will be tryin the allergy meds too1
u/wellnest19@OP Which antihistamines are you taking? I have some of these same issues. Thank you1
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36r/tresslessProof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. P...noeyys1380%9773.8stem cell therapy2026-03-10↗
commentercommentsentimentupvotes
u/Radiant-Community467Remindme! -1825 days132
u/1StationaryWandererOk so… when are we getting AMP-303 lol97
u/dorsei👀 William Rassman, MD, an Amplifica co-founder, adds, “The results observed in the frontal temporal region are particularly encouraging, as this area has traditionally been one of the most challenging to demonstrate a clinical response. AMP-303’s potential to stimulate hair regrowth in this region underscores its unique potential and sets it apart from existing therapies. Findings from this initial clinical study offers renewed hope for patients struggling with hair loss that have historically been resistant to treatment.”74
u/0zetoSo how does Ru58841 a topical anti androgen protect from androgenic alopecia then? No fr i get it, multiple pathways can be targeted but eh... androgens definitly are somewhat relevant39
u/oartistadoespetaculo5 years37
u/KamikazehogCan I get a TLDR for the TLDW? Jk thanks for sharing27
u/F0x_is_killReminder that Hair loss forums have posts from 2005 saying "just 5 more years" btw23
u/jeansarkozy1607yeah and the fact its an injection is even better no topical to apply and at least maintenance but i will be fully bald by the time this come out ....22
u/GRAND_PrepI'll wait for the haircafe video20
u/megaman2500Verteporfin activates trps1 after wounding, dr longaker talks about it in this video presentation at at around 18:30 timestamp https://youtu.be/CpfsAbOuOCY?si=Wp3aa2PMeaCTvlvw Furthermore, this paper by shamik mascharak et al Goes into it https://pubmed.ncbi.nlm.nih.gov/35077667/14
u/ItsToboLadsI'm getting flashbacks to brocolli boy13
u/The_Cabal_This guy again13
u/LWJ748A segment of the hair loss community reminds me of a segment in the fitness community. In fitness it's very well established what works. Yet you have a swath of people doing everything they can to avoid that while wondering why they don't get results. People seem to go out of their way to avoid anything DHT related. I started losing my hair in my early to mid 20s. I'm now in my 40s with a 20 year old hairline because of duta/min. Maybe something better will come along, but at present time you're losing gains avoiding what works.9
u/Jrlu92Let me guess, there’s a mouse out there looking like a young Rick James7
u/miyeetsGood research. I always had a problem with the "dht is the root cause crowd." To me it's quite ovioious dht is just a part of the equation of hairloss and of course, if you disturb an equation with a 5ar inhibitor, it helps, but it's not the cause.6
u/AppliedLazinessThey really did that guy dirty with the caption...5
u/TerryMiseryWhere did you read AMP-303 is osteopontin analog?3
u/TwistingSerpent93There is this study in which androgen sensitivity has been induced in mouse follicles, triggering miniaturization similar to that in MPB. I'd hypothesize that if you took two healthy follicles from a man's scalp, one in the "androgen sensitive zone" and the other taken from the base of the back of the head, and implanted both of them in the same spot (let's say the upper back), the follicle extracted from the androgen sensitive zone would display profound miniaturization in relation to the other.3
u/Quirky_Comfort_7083Dgaf its not available yet.3
u/Comfortable-Rock4349Remindme! -1823 days2
u/Zealousideal-Fox623they went after my niggas nose2
u/Own-Luck4169Measurable increase in hair count. From what they say is nothing wow at all yet you talk as if this is the real cause and is not, I can tell you 100%. Why? Is simple, the moment they will understand the real cause they will say: Hey we tried to fix this and the moment we did it, all hair grew back. Saying that PP405 won t work and this one will is kinda troll since this one doesn t have any outstanding results as you can read on their page. I think both will work but don t expect wow results.2
u/VolturmusThanks ChatGPT2
u/benshiro93Release date ?1
u/farcedsedRemindme! -3650 days1
u/Ok-Neighborhood4798If DHT is not the main cause of hairloss then why did it immediately stop after 2 weeks of me taking finasteride and slowly growing back now 9 months later?1
u/wonderboylsdI am not a professional in this field. Perhaps you are right. However, I fail to understand that if the effect of PP405 is extremely poor, why they have launched Phase III clinical trials and received such a substantial investment. Could it be that the purpose of this company is money - laundering? It won't be long before we obtain the results of the Phase II clinical trials. Let's wait and see. I hope you are wrong.1
u/jasko666Does this mean I can stop with Dutasteride?1
u/ROCKSTAR_LH_MENRemindme! -365 days1
u/Specialist-Escape300but what pp405 do is to directly trigger the follicle stem cell1
u/AloopOfLoopsAMP-303 is 15% regrowth. That is not so impressive. I mean i guess it is okay compared to minoxidil. We will have to see if more injections lead to more regrowth. If that it the case then it is interesting for real. Would be great of someone would inject some Osteopontin in there scalp: Buy it here freeze dried: https://www.sigmaaldrich.com/SE/en/product/sigma/o4264 Dissolve the powder in a sterile saline solution. Then dissolve down to maybe 2 ng/ml (just guessing and i want to guess very low for "safety") then inject in to scalp. The issue might be that real Osteopontin is a big molecule and might not diffuse very well. Where i assume AMP-303 is a smaller functional analog and not just pure Osteopontin. As that would make it better for injection and also make it patentable securing their money. Another issue is that large amounts of Osteopontin may be cancerogenic.1
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u/Odd_Sir_8705We have been 1 more year away for 10 years now….you know how long 5 more years away will be? RemindMe! -7500 days
u/TheHeftyAccountantI’ve been thinning leading up to and since swapping to Dutasteride about 1.8 years ago. I started PP405 8 months ago and had promising results for the first month but it’s since had no impact. Hoping this explains how my hair can continue thinning even though i’m on both a systemic and topical anti-androgen regime. edit: lol, i meant pyri, not pp405. what a gaffe-10
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37r/NooTopicsEverychem PP405 Patent Breakdown (3HPs, PP30 & 2HEE)sirsadalot1670%7473.7induced pluripotent stem cells2026-03-13↗
commentercommentsentimentupvotes
u/SpenseRogerInsane the amount of work that went into this. Will order to show support.positive20
u/caprisumsbasedneutral15
u/SonnyshutMay the hairline be with youneutral14
u/DeanoPrestonThere's speculation that this may reverse graying, too.positive6
u/Burntoutn3rdThis is an insane level of dedication coming out of a novel chemical vendor. Nothing but high praise here from someone on the academic research side.positive6
u/Big-Tooth1671Look it research chems, what more can we ask of a company. I have as much faith as i can in there stuff for what it is .they try be as transparent as possible admit when they get it wrong big thumbs up from me im no expert so take it as it as i see it and not gospel great prices great products a little bit work on customer services in getting back quicker then there onto a winner .Im sure not easy getting reliable staff for these sort of things. for them to be spot on im sure our pockets get hit harder and we not all in a place to deal with it . I got banned from nootropcs for life no reason after asking why im sure its because i champion and tell people that i go everychem . Love acd856 favourite product sure it gave me mind set to get off long term opiods .positive5
u/Unlikely-Blacksmith1Is there any signs of regrowth anywhere by using your product yetneutral3
u/Spare_Entry_2441I want to get 1 which one should i get? and would it work for beards as well? ?neutral3
u/ThemeAppropriate575Guys I have disorders and I can read what is posted here, can someone sum up what is written above? ?neutral3
u/Great_Cow6624Where can i buy pp405? ?negative3
u/makefriends420Hope we can figure out what is what, doesn't seem like figuring out the structure is as possible as it was with ACD.negative2
u/Kobiash1Impressive work. Agreed with the red herrings though. Companies often file patents for hundreds of molecules to hide the real one. 2HEE or 3HP might just be analogs. However, synthesizing cyanoacrylates and pyrrolopyridines requires incredible precision. Impurities in grey market batches could cause scalp issues which would mimic hair loss rather than fix it. That would be a big red flag for me at this point because it's a best-guess, which carries the risk inherant with experimental chemicals and unknown toxicity, plus stability issues.neutral2
u/BrainWashedChimeraThis is extremely impressive..positive2
u/Sufficient-Mall-4210Is this true? PP30 matches the public patent chemistry trail more closely than 3HP. The main reasons are: • The public Pelage/UCLA chemistry points to a cyanoacrylate MPC-inhibitor scaffold with an azaindole/pyrrolopyridine-type core, not to a simple “3HP” concept. • PP30’s structure fits that published family better: it has the same broad azaindole/pyrrolopyridine + cyanoacrylate architecture and uses a 3,5-bis(trifluoromethyl)benzyl motif, which is closer to the public lead series. • The patent language explicitly allows prodrugs and specifically mentions acyloxy substituents such as acetyloxy, which makes PP30’s acetyloxyethyl ester look like a more natural patent-inspired delivery form. • I could not find 3-hydroxypropyl / 3HP specifically called out in the patent or the public medicinal-chemistry paper, so 3HP looks more like a looser guess built from the same general family rather than the strongest fit. • Even EveryChem says it does not know what the real PP405 uses and that its products are only examples based on public patents, so neither is confirmed — but PP30 is the closer match on paper. So the shortest version is: PP30 looks more likely than 3HP because it lines up better with the published MPC-inhibitor scaffold and with the patent’s prodrug/acyloxy clues. 3HP still looks related, but less specifically supported. ?neutral2
u/Unusual_Jackfruit146Looking forward to hearing good newspositive2
u/SoupBandIs anyone trying it now? Please reply to this comment so I can better follow your changes LMAO ?neutral1
u/PuzzleheadedPeace360Hi OP, Im new to all of this but wd like to try. I see two products; PP30 and 3HP. Which one should I pick and what is the dosage. thanks!neutral1
u/West_Marionberry_819If you were to buy all three hair-regrowth treatments, would you apply them all back-to-back on the scalp as we don't know which one is the real PP405? Or would you trial each one individually (say 4-8 weeks) and see what sort of results are achieved this way? ?neutral1
u/Sharp-Huckleberry862You used ODEs wow very impressivepositive1
u/Sufficient-Mall-4210how did you guys order from Everychem? my debit cards don't seem to be accepted and I tried a few ?negative1
u/steve228ukWhat dose are people taking? ?negative1
u/Sea-Adhesiveness-928Any issue with ordering from everychem at the moment? Keep getting some error code that it doesn’t let me give my card details to make a payment? ?negative1
u/tribemember321Is there a tldr for negative side effects? Or is the worst thing that can happen is it doesn’t work (3HP) ?negative1
u/Tasty_Bite_1973I've ordered 8 bottles of 3HP. I'd love to know the exact dosage that people are currently using daily. Anyone here have that info? ?neutral1
u/Abel_091this is really cool and impressive but is it like a replacement for antiandrogen? meaning I get its a different mechanism but it seems best ways to treat hairloss (of what available) a) growth stimulant b) antiandrogen does this compound suggest no longer needing either if it works? 100% down to order I use a topical Finasteride. Does this need to be mixed or comes fully ready? ?neutral1
u/[deleted][removed]neutral
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38r/HFY[Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 11KamchatkasRevenge2120%5173.6PRP knee treatment2026-03-06↗
commentercommentsentimentupvotes
u/Positive-Height-2260Why do I think that at the end of this story, there will be a human who ends up with a dozen Ha'quinye wives?12
u/DrewTheHoboI am once again saying that I think Joan will lead a crusade to bring religiosity to the fuzzy wuzzies(and by that I mean save the men and overthrow the Matricians), granted I’m betting the Catholic angle will come in hard here for lower and middle class.11
u/KamchatkasRevengeLike the story? Check Out The Exclusive Perks on Patreon! Or Buy Me A Beer! Chylde's Archive Check The Entire Series Out On Amazon!6
u/BoysenberryMother128Woohoo!! Early chapter!!! Am I speed?? Hehehe!!! UTR!! This is the way!! Edit: so, the setup continues and the plan starts to take shape... I like it! A couple of weeks past I commented on a webcomic that it reminded me of those old comic strips on the sunday newspapers. The expectancy to read the next installment, the unfolding of the story in short bursts, the cavilalitions of the story direction... And that's exactly what I'm getting with your work, Kyle's, and a couple of other wordsmiths in Reddit. Thank you!! (And yes, I'm old enough to remember comic strips on the sunday paper...)6
u/thisStanleyone of his few civilian suites suits autocorrupt? set of rooms vs clothing ​ ​ as opposed to treating them like literal property When "2nd" class citizen is still too high, and you need to use scientific notation :{6
u/GadburnLooks like its time to give these discout Thalmor degenerates a taste of some HFY!5
u/JWatkins_82Woot New Chapter3
u/d_baker65Why do I suddenly want to date a Ginormous Snake Woman.3
u/Dramatic_Mixture_877Third!3
u/HFYWaffle/u/KamchatkasRevenge (wiki) has posted 614 other stories, including: [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 10 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 9 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 8 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 7 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 6 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 5 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 4 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 3 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 2 [Of Dog, Volpir, and Man (Out of Cruel Space)] - Bk 9 Ch 1 ODVM Special Event: Thy Will Be Done Ch 3 ODVM Special Event: Thy Will Be Done Ch 2 ODVM Special Event: Thy Will Be Done Ch 1 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 82 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 81 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 80 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 79 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 78 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 77 OOCS: Of Dog, Volpir, and Man - Bk 8 Ch 76 This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.2
u/d_baker65Why do I suddenly want to date a Ginormous Snake Woman.2
u/Right_Bell3252well, I think this is the soonest I have yet been able to post, looking forward to the inevitable Undaunted response to this would be empire.2
u/itsetuhoinen"Change forced upon a people without the will of the people..." Yes. Rather.2
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u/unkindlyacorn62so propaganda plus getting one of their men to kill the matrons?1
u/Cavetroll01Greetings wordsmith.1
u/TalendelUTR This is the way.1
u/JWatkins_82NEXT BUTTON IS MISSING1
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#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
39r/NatureofPredatorsThe Hunter Chapter 30Win_Some_Game2220%4473.3PRP knee treatment2026-03-15↗
commentercommentsentimentupvotes
u/Brave-Stay-8020Cole is just having a grand ole time:35
u/VenlilWranglerWow, Cole is having just a fuckin awful time. Lost his yandere girlfriend and got covered by a PTSD hedgehog (no, not that one). No Lalu, no Pini. At least he has his Fahm and Fam.35
u/Rpitre1I hope they did not fuck up Cole too hard with the teeth. Although it would be really funny if they sharpened his teeth because "the predator will get mad if we don’t fix it." Also I hope Cole does not compromise with his meat-eating habits. There's nothing wrong with eating meat and I hope he sticks to it and he doesn't become some "Prey" pleaser especially if Eva tries to make him stop. I hope Eva learns about human culture and the importance of food in the future and comes to accept Cole has who he is. Maybe the dog will help with that... but idk 👀26
u/Adorable-Ad5225Wow, even the Porcupine tried to save him... Poor Cole24
u/DrewTheHoboWait, when do they find out about the Farsul shenanigans? And how’s that gonna affect Eva and Pini?22
u/Commercial-Gas-7718Oooooooh, baby, this chapter just ends too SOON! Another banger.15
u/defiantdoctor95Might just be me having a perception score in the negatives but where did his new teeth come from? (And on a lighter note, how many times do you think he's gonna bite his own tongue by accident while getting used to them?)15
u/DOVAHCREED12Hi I'm dovah and I'm the fastest venbig alive I AM SPEED OFFICIAL VENBIG SEAL OF APPROVAL <image>13
u/luizbielBehtek, harvesting carcasses in cole's backyard: "the fuck you mean meat makes prey sick?"12
u/YellowSkarGreat chapter, I wonder how Cole almost killing that other guy with meat is gonna impact the main-NoP reveal. The one where it's revealed stuff like that allergy is the work of the federation. Edit: I mean how it's gonna impact his and the others' reaction to it. Before it was as simple as "Ha! I knew none of this made any sense!" on Cole's end, but now it's "Okay I was still right but I almost killed someone because of it so... let's call it a draw." at best lmao.11
u/gabi_738God, it surprises me that Cole is still willing to help them even after being betrayed and despised by one of the xenos he trusted most, after practically receiving terrible medical treatment and having his "friends" on that planet fear or despise him for being human. Cole needs to release that frustration somehow.9
u/Zealousideal-Back766Sad Cole :C8
u/gabi_738Okay, if I don't keep reading, I won't be able to sleep peacefully, but seriously, Eva really stirred up a lot of violent feelings in me in this episode because of how she treats Cole and shows that she still has federal propaganda stuck in her head. She probably didn't mean to be cruel, but AHHHHHH!!! Argentine sounds of violence7
u/Prestigious-Ad6728He needs people who understand him and unfortunately, most aliens just don’t fit that. Cole had the right to be angry but they just won’t be able to see it like that because they’re too biased. Behtek is the only one Cole has that could be considered healthy to be around.7
u/Golde829as the 10th Doctor put it "New teeth.. that's weird..." i don't think i could handle that, a lot of my sensory issues went to my mouth apparently honestly not surprised the medics just. did bare minimum for Cole also when i saw a link i expected it was gonna be the Femur Breaker for some reason I look forward to reading more take care of yourself, wordsmith [You have been gifted 100 Coins]7
u/TheShapeshifter01Old crochety gojid is even covering for him. Huh, wonder what his (the gojid) thought process regarding that is. The medical treatment for poor Cole, yikes.6
u/KwanicovI didn't expect the murder birb to be the first fed to see him naked Jokes aside, this entire situation would make even the strongest person miserable. Even if Eva and Pini didn't leave him, knowing that you almost killed a person while doing, what you thought at the time, to be a harmless act of spite, would just be plain horrible. I do hope the story further explores both sides trying to reconcile with their differences in regards to meat eating, instead of going the usual route of one side just folding, like it's often the case.6
u/ErinRFI can see Cole retreating and isolating after this, then not renewing his contract. Herd rejection is a bitch4
u/Bow-tied_EngineerOuch. Poor Cole. I can't think of a single thing worse than someone I care deeply about flat out saying they don't feel safe with me.3
u/IntrebuteWow even Ketchup covered for him. That means that if what he did gets out, it'll be entirely on whether he himself comes clean with it. Frankly I hope Cole starts being more receptive to "prey sensibilities" instead of being so cavalier about it. Granted, we the readers know things he doesn't, but from his point of view he fucked up big time and if he continues being this way then anything that happens from now on is entirely based on wilful ignorance. This is his one mistake to reconsider his priorities.3
u/SlatepawsWay to stab him eva... No wonder he had a psychotic breakdown, the 'one' person he was opening up to did that.3
u/JanusKnarusAfter the body now the soul got mangled3
u/abrachooThey gave him new teeth, huh? I wonder if they made some cosmetic changes to them?3
u/Ferrum-Cl2So they all survived, all lied, but now angry space porcupine has gone full Ahab mode and worse, Eva and Cole's relationship: <image> Why?! It was so pure and innocent . A little warm light in this dark cruel world. And then you extinguished it with a bucket of ice water. Nyssora will never not be good enough for Cole, with her compassion and affinity for hunting. Just because the bird is cute too, and Cole called her name in his sleep, doesn't mean i wouldn't not ship them. There is no way in hell, that they couldn't fall for each other.2
u/pepemariozInteresting to see a fic where feds are aware of the effects of the cure. Can't wait for everyone to learn why it exists in the first place.2
u/Mysteriou85Great chapter! We get to see the aftermath of the fight with oneeye!2
u/BrucelaBron*Helta's tail coiled and lashed. “He was strict and a hardass. I can't count how many times I've gotten in trouble and been chastised by him…” Then she relaxed, and a bittersweet smile began to appear, “But… He was also so supportive of me. Some days I thought he was my biggest enemy, and other days I thought he would make everything right…”* Huh... didn't expect that description to resonate so strongly with my own experiences.2
u/Kind0flameIt looks like there is a bit of a reckoning for Cole not respecting the population's culture. He knew how badly they would react to meat, but it took someone actually getting hurt for him to realize it isn't just a ridiculous belief he can ignore. You have to meet people where they are to get them to change. I think he is starting to realize that.2
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
40r/NatureofPredatorsFarsul's Best (Predator) Friend [17]muakling1600%6673.2PRP knee treatment2026-03-05↗
commentercommentsentimentupvotes
u/Minimum-Amphibian993Hmmm I imagine this version of Minecraft is the UN censored version. Since zombies in Minecraft drop rotten flesh. Anyways besides that everyone in this story is gonna have to go through something.23
u/pedro5414Live firidiona reaction <image>19
u/copper_shrk29I can't help but imagine these goofballs making a hodgepodge of wildly different mods in a very chaotic game night lol12
u/Ill-Mud5750what is that abomination in the miniature?5
u/ISB00I wonder if Firidiona will also change jobs like Griia.5
u/YellowSkarHell yeah, Minecraft4
u/Commercial-Gas-7718Seems like a nice lull in the craziness, and I'm betting that something shipty will happen in the Wild Zone. If not, then I'd be glad, but if not... Anyway, Ulim's backstory!!! Yeah... More sad Good chapter!!4
u/TheOneWhoEatsBritishI like how the immediate response to "You probably see me as if I've got some kind of mental disability", was for her to study his physique and say "You look pretty normal". She did NOT cue in on what he meant, and if anything, she was thinking of physical disability.4
u/Enclaveboi4everThe Courier gives this chapter a 10/103
u/JulianSkiesBahahaha, oh poor Firi. What a bizarro nightmare XD Then again her family is like that right now. XD Also, uhn... Wildlife trip sounds Real Omnious here.3
u/muakling[removed]3
u/gabi_738Wait a second... isn't Firidiona trying to win Carlos's favor and approval? That means Carlos is fulfilling the fantasy of the average refugee from Venlil Prime, and that means it's not a fantasy but a reality. Okay, at what point does the corruption of our favorite Mexican begin?3
u/Bow-tied_EngineerFuture minecraft has peaceful mode but with hunger? Why can't we have this IRL? :(3
u/Onetwodhwksi7833This is hilarious3
u/Bow-tied_EngineerI just had a hilariously awful thought. I wonder if Marcos is the sort of person who would find a Farsul MILF on a dating app...3
u/TheBrewThatIsTrueAlways love the story!2
u/arturocan!subscribeme2
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41r/NooTopicsDid this come true?ps4roompromdfriends46980%38972.9stem cell therapy2026-03-09↗
commentercommentsentimentupvotes
u/Party_Candidate7023yes, i am so sick of the FDA waging war on sunshine!151
u/HamHockShortDockWhat is their obsession with ivermectin and hydroxychloroquine?? How is this making them money?87
u/Virginia_HallI have not yet found my favorite psychedelics on Amazon.43
u/VkardashFirst off. He's the head of HHS and not the FDA. Does he have influence? Yes. But the FDA has its own commissioner, regulatory process, and Congressional oversight. And none of this shit he said ended up being true. Surprise to no one. The FDA still regulates everything he mentions in that tweet. Raw milk is still illegal in most states. No sweeping reform in psychedelics. Stem cell clinics are still highly regulated. None of these systems disappeared. It honestly sounds like he's just making stuff up. "War on vitamins"??? You can buy vitamins literally anywhere. 😂42
u/itswtfeverbMarijuana? ........Oh, I forgot the alcohol industry paid to nix it25
u/Ashamed-Status-9668In 2025 he laid off 3500 folks in the FDA and in total about 10,000 folks in the U.S. Department of Health and Human Services (HHS) which includes the FDA.22
u/Optimal-Hunt-3269Don't forget high colonics!13
u/vonbehren[deleted]12
u/sirsadalotHe did absolutely nothing. Similar to how Trump did the opposite of everything he promised. TL;DR? Nothing ever happens.10
u/pdublyPerhaps a better way to ask this question would be to decompose what he’s saying, and attempt to find evidence of any progress. Then perhaps extrapolate out… I feel many in this sub are missing the point, and being overly political. He is a political appointee, and probably misspoke somewhat. Disclaimer: I’m no cult member. :) To be fair, “supplements” are typically all thrown into one bucket by mainstream science and dismissed out of hand. What is generally said is that supplements are not effective. The truth is that there isn’t robust evidence to make such blanket statements. Which is to say that the studies haven’t been done which would ‘prove’ whether or not ‘supplements’ are effective in improving health. Not to mention that throwing all supplements into one bucket and making generalizations is completely disingenuous. Nonetheless, there is research on some specific supplements that show they either do or do not have an effect on human health in specific contexts. One off the top of my head is creatine. My point is that ‘supplements’ are typically dismissed out of hand by mainstream health professionals and scientists, many of which never learned about the topic in medical school and do not have studies that would to point to their conclusions in a meaningful way. Their statements are then typically interpreted (or explicitly said) as ‘they don’t work’, whereas the truth is that broadly there isn’t enough scientific research nor studies to say conclusively either way. So, if mainstream science is dismissive without evidence (ironic), they are lending credibility to that argument, while the truth is there isn’t enough data, evidence, science, research to make that conclusion. Essentially, they are stigmatizing the topic, which can have negative downstream effects of creating a general lack of interest in a topic that could in fact lead to positive outcomes from research into these substances, which happen to be largely unpatentable. “FDA’s war on sunshine” sounds absurd, but there is concern that sunscreen could block the bodies ability to create vitamin D. There is at least one study looking at this specifically. I don’t recall the results or robustness of the findings. You’re welcome to look that up on the NIH website. Anecdotally there is also some research out of Australia that looks at sunscreen usage rates and skin cancer rates over time (correlation does not equal causation). Again, you can go look that up yourself, the science is real. It is established that a majority of people in the U.S. have low levels of vitamin D, do not get enough in their diets, and it’s a health concern. Regarding peptides… There are recent changes which appear to be paving the way towards better standards and regulations to make peptides safer for end users by limiting fly by night sources, improving oversight of compounding pharmacies, and not penalizing doctors and end users. This is happening in realtime. The peptides user community crowdsourced testing of some of the research chem sources, and it’s a bit scary. I’d tentatively call all the above progress. What about the horsey paste? In the end, there may be some value in ivermectin use with covid, perhaps simply via some anti-inflammatory mechanism. I’m not an ideologue on this issue either way. I think being open minded and doing the science is the right path. We don’t have conclusive science (only clinical evidence) on whether it helps or not, and to what degree it is helpful or harmful. Again, it’s been politicized on both sides, and as a result we either miss the potential benefits or risk the potential harms. Who does benefit from the fighting and lack of science? It’s a fair question, but probably not for this sub. I’m not defending anyone here, just humbly attempting to make a more nuanced point that people tend to jump to conclusions without evidence, and in a sort of scientific-ish r/ where we’re sorta fringe anyway, we ought to be taking a more scientific and objective look at stuff like this. It’s not doing ourselves or anyone else any favors to continue to contribute to misunderstanding by politicizing topics and derailing objective science.10
u/OrganicBrilliant7995Regardless of whether you like RFK, the FDA is and has been the greatest obstacle to health progress. This is what most voters want, though. They'd rather have safety over reward and the risk that comes with it. If we have to have a few corrupt officials paid off by pharmaceutical companies, so be it.7
u/Cautious-Ad-9554If you want this to come true you have to support unions and establish a more realistic life/work balance for American workers. You also have try and do things like have employer based insurance refund gym memberships if you go. This admin is very anti worker. RFK’s goals are unattainable for the masses bc of who he works for.6
u/xiovelrachRFK is functionally braindead and has setback public health decades.6
u/irlostrichIf we’re being charitable, then maybe we could say his attitude contributed to the buzz we see about grey market peptide usage (eg the “chinese peptides” craze on twitter). I personally think this would have happened in any timeline with ozempic though. And I’m tempted to say that the state of affairs for the nootropics demographic in general has actually gotten worse during this administration due to tariffs making it harder for us to import from india and china.5
u/Full-Shelter-7191It’s based of anti-scientific rhetoric and the false premise that somehow the FDA is trying to surpress your access sunshine, vitamins and exercise5
u/painalpeggyAre people healthier yet?5
u/Ok_Refrigerator9461We’re all going to die.4
u/MisterallrounderRFK is against nature..he is trying to ban Kratom yet here he is saying that he is FOR nature...it's sickening3
u/Noblez17I'm Down for psychedelics at least 🤷🤷‍♂️3
u/Jwbst32Glyphosate for all !!! 😂😂😂3
u/Actual_Musician_4157Lmao nothing changed3
u/nonlinear_nycWe got… roundup in our food supply.3
u/[deleted]Funny that the Trump admin is taking all that pharma money and they’re making record profits, again3
u/Automatic_Opposite17Says the heroin addict, coke-head brainworm guy.3
u/LessMention7652Why did he forget methylene blue and MMS?2
u/SoggyGrayDuckLikes peptides but against 7oh. Someone just needs to get him to sit down with the 7oh hope alliance. He should understand the benefit. I think he was one that used benzos or liberum from a doctor for several years after stopping street drug use. It's something you'll see is actually quite common in older AA stories. It's like a 5 year period of something you can use to take the edge off but won't destroy your life at the same time (historically controlled by the number of pills in prescription) if you mess up and have a bad day.2
u/No_Opportunity1934Bro hasn’t even gotten red40 off of shelves though?2
u/popcorn-triviaHasn’t come true for peptides. I think more and more sites get shutdown (b/c semaglutide peptide cuts into Ozempic profit, etc).2
u/BGMilanHere come the reddit scientists2
u/No_One_1617For the rich it has always been true2
u/SillySpoofGood thing FDA stopped suppressing sunshine and exercise. /s2
u/Inevitable-Cherry598But we're using toxic pesticides proven to cause cancer because Trump loves Monsanto.2
u/xbt_The peptide part somewhat improved very recently, a list of them recently got approved to be compounded in the US. Not sure about any of the rest.1
u/Traditional_Air_6867“Post Meridiem”? Woah, dudes really accessing 100% power here…1
u/cs_legend_93Make dmt legal 100% and then I'll believe you.1
u/surstrommingsexNew foundation of RC scene since NL ban? 🥲🤣🤣1
u/SamPDougWhat a good-looking question! Lol, no. And based on what I’ve heard from RFK jr lately, what little change there will be is going to be very slow.1
u/Leading_Matter_1168Oh thank god! I’m so ready for the drugs1
u/hoteppeterIt’s in progress1
u/IncandescentSplashAs someone who has benefited enormously from psychedelics, I hate seeing the thing that helped me become associated with this completely unqualified Trump grifter and named in the same sentence as ivermectin and hydroxychloroquine.1
u/michaelmhughesWell, the moron is responsible for the rise in measles, for one. He’s a dangerous lunatic whose face looks like an old shoe.1
u/Ok-Parfait-9856No, the current administration has shut down peptide vendors. They do the opposite of everything they say.1
u/Conscious-Comment-66Sunshine and milk came true!1
u/ScaryLetterhead8094But also the hemp bill is making CBD much less accessible. Right? So what’s up1
u/Olga2757He forgot snorting off of toilet seats.1
u/ketchupisfruitjamhe had me at the first half I'm not going to lie. broke clock is right twice a day1
u/DrbilluptownHe has such vast medical knowledge. /s1
u/fleetzeI love how he's mixing in the BS like. Sunshine, bloodletting, exercise, flat earthery, get good sleep, drink mercury.1
u/SCHawkTakeFlightNot yet, hoping we dont go back to non evidence based medicine. Don't have to prove a therapy works before consumers spend money on it or at a minimum won't hurt you. Also, at one point I am betting ivermectin, hydroxychloriquine and hyperbaric devices were patented...thats generally how new innovative tech works. It gets patented to secure profit for x time. After x time anyone can make it. Otherwise, there is disincentive to make anything new if someone can copy it right away and sell it cheaper because they dont have to recoup all that development cost.1
u/DizzyMeatball1791It’s crazy that a man in recovery wants to promote psychedelics.1
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42r/recoverywithoutAAThe truth of Bill Wilson's AA Start Up Brand & Franchise you need to knowTruth_Hurts3181210%8172.6PRP knee treatment2026-03-22↗
commentercommentsentimentupvotes
u/sitonit-n-twirlBruh this is great. The brainwashing is so complete inside and outside the cult. It is so frustrating to talk to therapists or health professionals, they’re all “it works for millions of people” and assume my objections to it are just me being a bitch. They have no idea of the toxicity of those cesspool meetings. The predators, the mean gossip and backbiting, the cliques and bullying, the all around just plain lack of self awareness and dipshittedness. What’s “cunning baffling and powerful “ is the hold that this idiotic childish bs has on society. Thanks for this great post39
u/LibertyCashWow, I knew about the whiskey but not the rest. It tracks perfectly tho, doesn’t it? Cancer victims get legitimate treatment. We get a bullshit program that tells us our disorder is because of character defects and spiritual maladies and if we aren’t “cured by AA” then it’s our fault it failed, not that the program is shit. And even our government is good with mandating that shit for people. I mean it tracks with the Christian majority mindset this country is stuck in, but man, is it some shit. Imagine victims of any other major disease/disorder being told to just confess their sins and pray and they’ll be fine (and if they aren’t, it’s because they didn’t try hard enough).20
u/PippinOfAstorai cackled like a maniac (in glee) as I read through this. thank you for sharing18
u/ben_quadinaros_stanYeah it’s always felt like it’s own religion to me so I’m not surprised everyone gets the magical version of its history. Frankly although it’s annoying how far the reality from the taught version are I really think even if it were all true AA doesn’t have much to offer besides community. Everything else is kinda just magical thinking.12
u/nickpip25This is great! Thanks for posting this. When I left a few years ago, I did a deep dive of research and read a few books, such as the US of AA, that dig into some of this. The Orange Papers are great, too. The one thing you didn't mention is Marty Mann - the "first woman of AA." She was basically the PR wiz who helped spread the word, etc. Attraction rather than promotion, right? Lol But yeah, AA is a scam like everything else in America, and Bill W was a con man. It all makes perfect sense when you go to meetings and realize he created this whole BS system that continues to this day. He was the original 13th stepper, and the program never worked for him. Also, the claim that AA "has helped millions of people" isn't supported by any research. While that may be true, it has probably hurt millions of people, too.10
u/North_Crow_7600Great post, 318. Have you read the Orange Papers, which are freely available online?9
u/MembershipSolid7151This is fascinating! Thank you for sharing. How do I access your substack?8
u/AnnoyingOldGuyI was baffled at a meeting where there was a portrait of Bill W. front and center, like he was jeezus8
u/SouthernEvent6789My thoughts: Dead on. I studied a lot of AA history and what you have written has made clear a lot of things that just did not make sense. I spent 25 years in AA listening to the BS over and over and over. The belladonna treatment, there is a local pharmacy that has an old bottle of belladonna. The shit that is in that would make anyone have a "spiritual awakening". I know enough about Bill Wilson, he was not the stand up guy the so called big book makes him out to be. He was a womanizer, a cheat, a liar, and everything else you motioned. He was and is a fraud.6
u/[deleted]The big book is shitty reading, especially for ancient literature. It’s like a nine year old wrote it. An honors nine year old, but still.6
u/Sea_Measurement_1654I always wondered why Bill waffled on for all those pages despite stating his program was simple. So it was a deception? A hustle? Damn!! I can't stand how recovery language turns people with problems with alcohol into naughty dependent children who "hurt others". Considering that alcohol is marketed as a core part of many cultures and is behind a huge corporate profit machine I've always thought that sparking guilt and shame in drinkers was a smokescreen. The way the whole treatment model institutionalizes people (threatening their jobs and responsibilities) instead of just making at home detox support easily funded and accessible: so Bill and AA started all this? The monetizing of that illness model? He never stopped being a salesman? He was no different to the other 13:step creeps I met whose wives suicided? Ffs.  I'm not surprised, now that you've linked all the information together. Thank you for curing me of aa, permanently.  Thank you. Your research is good. I hope you publish it and mainstream AOD treatment starts to reflect on and question that model.  Vast change is needed.6
u/Top-Geologist-9213Wow I didn't know any of this!5
u/SouthernEvent6789Bill W. Oh…. Least not forget Dr. Bob. Both are and was frauds.5
u/gofeedmeBrilliant. I had known most of this, but not all, and your presentation of these facts is compelling. AA is a deadly scam. In what other area of medicine is 1935 thinking still the standard of care?5
u/Recent-Log-2999You hit the nail right on the fucking head. Thanks so much for the history lesson!4
u/barely_sentient4444I know to some this may sound just as insane as the story told here, but I feel compelled to share it because it's so simple and true to my experience. I was in AA for a year and four months. I was totally in-deep and brainwashed. At this time I was on the precipice of being given leadership roles and a becoming a sponsor...even though I wasn't ready. I was on step 6. By suggestion of a friend I went to a healing session with a Shaman from Peru...at random. I'd had a horrible week with my untreated ptsd and I was extremely mentally and physically unwell as a result--something that AA always swept away and attributed to the sickness of addiction, not trauma. For the ceremony I laid on a bed and the shaman spent about an hour performing a cleansing ritual, doing a shamanic journey to a beating drum, and he blessed me. At one point he said my ancestors wanted to come into the ceremony. I said sure. When I left the ceremony I noticed two things were different: I felt completely restored to my equilibrium from the trigger episodes and I had one extremely clear message my mind. I was in a cult. I just very suddenly understood that I was inside something harmful to me and to others. That I was being healed to mold other people into a servant of this problematic program. I booked out hang outs with friends for the next 4 weekends and packed my shit up, did not look back. I was so vulnerable! AA may be a spiritual program, but it is not true sprituality. This read is very creepy and disturbing...I lived in Ohio during all this and it's so creepy to think back to the "pilgrimage" people would take up to the Oxford house in Akron. And that no one in my life was like "hey are you ok? You know I've heard AA is a cult right?" That whole part of my life almost feels like a fever dream.4
u/MysteriousSyrup6210Now I understand what it is to be free. For real. Thanks3
u/papitaquitoOP… can you share some sauce for this? Just want to be able to provide sauce other than a reddit post if possible thank you!3
u/MyNameis_budYour write up reminds me of the Addiction Solution podcast. Especially where you wrote that it was the individual driving their recovery the whole time. Gotta break free from the conditioning that it’s impossible to develop new disciplines by reevaluating alcohol and other substances. Thank you for posting3
u/sirensideeffectsWait sorry if this has been asked but could I possibly be directed towards some of the reading that supports these claims? This is so interesting (though not entirely surprising) and I want to know more/ verify2
u/Ill-Address1151When is the book coming out? I’m thinking of writing one myself this stuff is so interesting. A great read above. I have one question. In every market there is demand and supply. You are arguing against the supply above - $42b recovery market in bed with AA…but what about demand? Why does it work for a lot of people?2
u/LifespupilI especially laughed at the use of hallucinogens and preying on young women (a tradition that goes on to this very day) and fascist recruiting material (cuz I know a bunch of fascists that love the ef out of 12-step) Bunch of moronic assholes that preach this garbage as the only way to get sober/clean make me want to puke.2
u/[deleted]"Constitutionally incapable of of honest" Its abuse. Makes me angry. Really. pissed. Oh, he can't get this program lets marginalize and shun him, treat him like he's a lesser animal. or He left the program, lets tell every one that he's miserable hopeless alcoholic that will nerver stay sober. Only people that do what we do can't be miserable.2
u/hollowblink55The history is definitely a lot messier than the official version they tell in meetings. Learning about the Oxford Group and the early power struggles really changes how you see the whole "spiritual" foundation. It’s better to know the facts than follow a myth.2
u/strawberitadaydreamJust curious if you have some sources you can cite?1
u/Ok-Magician3472Much information here. I can smell remnants of the religious authoritarianism in the halls. Though also see spiritual marginalized speaking and forming groups where all are welcome. Interesting topic. Any source recommendations? I have hear of oxford group, but not much else.1
u/Background-Ad3308While im willing to believe this and none of this surprises me because I understand how powerful capitalism is in the US...where are you getting this info?1
u/Lewt007Is this from the orange papers? https://orangepapers.eth.limo/orange-cult.html1
u/TheTankIsEmpty99Does posting this help your recovery?-1
u/dr-ncI never had that addiction, and never took that program. However, since it helped many people around the world, despite the shortcomings of its founder/founders, that was not due to his own mind, but due to the fact, that the program's principles are to some degree, a bit distantly, related to the principles of self-examination, acknowledging one's evils before God, and shunning them as sins later on, with the help of God, and also with the friendly moral support of others. The fact, though, that it was somewhat deprived of its true spiritual essence, that is, from the principles out of the religious books, made it work only superficially, not without problems of its own. In its more authentic form, when divested of all additions and simplifications, those principles are instrumental in dealing with various kinds of unhealthy and evil addictions, of both natural and spiritual nature. Perhaps, it is the lack of a number of the more immediate spirituality related aspects of those principles, with their reference to the Lord and the Word, that made this program less effective with regard to certain challenging areas of Bill Wilson himself.-5
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43r/nosleepMy manager keeps telling me not to worry.Individual-Offer-5633030%2372.5PRP knee treatment2026-03-18↗
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u/OkLeg4914I’m convinced that directors need to use this sub as inspiration for horror movies. This is incredible. I hope to hear the next installment soon20
u/Selene_16OP why are you incapable of following rules? Like seriously why?16
u/rtiveronWell, at this point i'd say fuck it, ask Terry when he comes by. He was interested in the radio, he definetly knows what happens there11
u/DroppinDwarvesI definitely wouldn't go to building F. Use the dental, save up some money, seems if you go in there both become irrelevant. Looking forward to updates!11
u/RayRay_46I love your sense of humor. I think the worst part for me would be having to keep the radio on at all times on a single station. I wonder how dangerous it would be to put headphones in and listen to other music while the radio played quietly in the background. Would Eversafe Self Storage Solutions LLC, or whatever weird energy is behind it, take offense to that?9
u/PlumAffectionate4575this is giving me tales from the gas station vibes8
u/Fund_Me_PLEASEHonestly, that’s not a bad gig, for 19.50 an hour. I only wish I myself could something so laid back that pays as well.  You were smart to keep that job, OP. Odd as it is.7
u/BusinessheoDale knows way more than he’s saying.7
u/Proper_Ad7132Self-storage is also rented by people who are without homes to store their belongings, by nonprofits with small offices and other groups that need to store things. Not just hoarders or materialistic conspicuous consumers.6
u/Lavender1123Your experience is absolutely fascinating. Be careful, and please keep us posted.6
u/tattoo_mom4Maybe ask terry about building F. Can’t wait to hear more about your job!5
u/survivorterrawould love to see more of this!3
u/digigoose01A headache that never becomes a migraine is, in actuality, a blessing. Though one you probably can't recognize until after a crushing migraine leaves you crying on the floor in your own vomit. Good luck.1
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44r/JUSTNOMILDon’t want MIL near me or our baby - Advice wantedProfessional-Sky-6701040%9072.3PRP knee treatment2026-03-27↗
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u/Evil_Creamsicleit was taking every bit of self control to not immediately throw her out of the house Throwing her out is exactly what you should have done. It doesn't need to be a 'conversation' it just needs to be you telling her she's not welcome and hanging up the damn phone never to talk to her again.19
u/DejectedDILShe would absolutely never step foot in my home again after calling me that. Please rid this woman (if you can call her that) from your life.18
u/QueenMadgeJust from here you've been called a bitch and a whore (that you know of), he's been called a waste of space/lazy and she hates him, she admits to parental alienation against her own brother and alienating you guys from your niece with bad mouthing. Again this is just the things you guys even know about. She ditches you for months hoping you'll chase her. Saying nothing is getting you nowhere. How long until your baby starts getting alienated from you? Because that peppa pig anecdote was the start. My advice is to make a physical list of everything you can think of that she's done, present it to your husband and ask if he would think it was OK if you did this stuff to your own child. Ask him why its ok for him. Then announce that you'll be protecting your child and yourself with no contact from her. He's welcome to keep at it but he must know she will ramp up her manipulation and horrible behavior and to keep you out of it. I suggest therapy for him.15
u/justhewayouareI don’t have any advice cause you already updated. However, I laughed so hard when you called Peppa a B cause DAMN! She’s not Caillou but in my book she’s second place.14
u/fryingthecat66When she called me a whore,that would have been it. I would have kicked her ass out and gone NC with her disgusting ass If DH wants to still keep in contact that is his prerogative but you tell him that you and LO will not, that she'll never see your daughter again14
u/SomewhatBougieAuntieYour husband can do what he wants, but and your baby can cut MIL off for yourselves. Do not allow her in your house, do not go to her house and do not allow your husband to take your baby anywhere near her. He can either whine about or get with the program.14
u/KuchalooI don't know what MIL could have done differently if she purposefully wanted you out of her life! Good on you for choosing peace. I don't know how or why you held back at the first instance of her über rude demeanor, but that's over now. You don't ever have to see her or hear from her again. There'snothing to salvage.13
u/Striking_Physics1894Why are you even asking this? You should just go NC and block this bitch who apparently hates you, her own son and grandchild. Life's too short for that.13
u/Chi-lan-troI think that you should read Harriet Lerner’s “The Dance of Anger”. In her book she talks about how under-reacting is JUST AS BAD as over-reacting to your feelings of anger. That when you under-react, you build resentment, which continues to build until you snap and over-react to something small and then you have to eat crow. But if you react appropriately you will have respected your feelings of anger, and you will feel GOOD. In this case you say that you’re pretty confrontational but I find that you’re NOT reacting ‘enough’ in the moment. I assume it’s because you don’t want to over-react. I think it’s perfectly valid to respond to her, in the moment, but it doesn’t have to turn into a full-fledged fight. “Did you just call me a bitch?” Or better yet: “Well, that was not on my bingo card for today, I’ll be taking my baby now.” And go into another room with the baby, close the door and don’t come out until shes gone. Text DH “your mom called me a bitch, can you ask her to leave and let me know when she’s gone?”13
u/bookwormingdelightI’ve come in after the edit you posted, but therapy did amazing things for my husband processing MIL’s behaviour. We set really firm boundaries. He went temporarily NC while doing therapy and then considered group therapy with his parents. When the therapist spoke to him one on one before group therapy it became very clear that neither ILs have made improvement, they want the answer on how to “fix it” and there were heaps of other issues raised by the therapist. My husband went and saw his own therapist again and realised he didn’t want to deal with this anymore and went permanently NC. Best advice I can give is just do regular check ins with how he’s feeling. Validate his feelings. I kept my complaints factual and not emotional about her. As much as I would like to, I did that with friends. With him it was easier to process facts. I also made it clear that he’s an amazing father and husband and protective and it’s not fair he has to feel like crap every time he sees his family and deal with issues. Since going NC it’s been PEACEFUL.12
u/JaeJames138Why on earth do you allow that rancid cow anywhere near you ?! Holy crap, cut her off, and tell SO she's not to be near your children. Ewww. Just gross !10
u/Jackaxed014WHY are you or your husband or your BIL/SIL letting this awful woman stay around your children? What exactly do you think someone this immature and toxic is going to teach them as they grow up? Jettison this woman out of your life and advise BIL/SIL to do it, too, though they may be more enmeshed because BIL is the golden child. I seriously do not understand the thought process here. This woman is petty, cruel, manipulative, and just straight-up immature. She has nothing to recommend her as a human being. She has nothing to offer you or your children on a human level. She "ices you out" like a pouting child and openly insults you in ways I would never accept from anyone. If she calls you a "whore" and a "bitch", what kind of things do you think she's going to say to your daughter, her less valued grandchild? Sorry, but just like-- advice?! The advice is cut this woman the fuck off. Never let her into your life again, and make sure husband is on the same page. If I was your husband I'd let the bitch die alone, because she's made it clear she does not love or respect him and she only wants to keep him around so she can hurt him.10
u/alwaysabouttosnapI understand you don’t want to ice her out completely. But at the same time, you sort of imply that you do. You don’t want contact with her and you don’t want her to have contact with your baby, all for valid reasons. I understand she’s your husband’s mother and you don’t want to push him to not have contact with his mother. The good news is that you don’t have to! He can have as much of a relationship with his mother as he wants. But you and your child don’t need to, she doesn’t need to be welcome in your home, and you can tell anyone (especially her) to politely fuck off if they have a problem with it. As far as I’m concerned you don’t get to call me a bitch and a whore and say you don’t even like your own son and still get access to me, my child and my home. If your husband has no spine and refuses to let go of a relationship with her then that’s a him problem. But you’re a mother and you have an obligation to protect that baby and you need to have more respect for yourself.10
u/Emotional-Place9446I would’ve been NC for a long time already.10
u/TargetWild9004I can’t understand why you guys would want someone around who insults the both of you so openly. She’s already doing it in front of your child, and has admitted she uses her niece to get what she wants. You guys will be no different. She will not change. She will keep treating you like the dirt on the bottom of your shoe. Do you really want this person around your child? Someone who called me a whore AND a bitch would not be stepping foot in my house let alone holding my child. If you’re as confrontational as you say you are you need to be that person and then not care about the fit MIL will throw. She keeps doing it because you let her.10
u/sjyfflI think you definitely need to call her out on the rude comments OP. She straight up called you nasty names - twice. And doubled down when given an out the first time. She knows what she’s doing and because she hasn’t hit a barrier - yet - she keeps doing it. Next time - you need to walk over, remove child from her lap, and say, “Since Nana thinks it’s ok to say that Mommy is a b****, then Nana should go home.” End of story. Once the tears start, you simply say - she said it, you heard it, and there’s the door. She should not be welcome until she can learn some respect. She’s insulting you in your home, OP. In front of your child, and by saying nothing, it will not stop.10
u/where-ya-been-locaBest option: cut her out of our lives and never speak to her again. She is so disrespectful and doesn’t bring anything but stress and anger and pain. Other option: call her out every time she says or does something. That’s enough of no one being confrontational. She’s an intentional bitch and should be put in her place or she’s never welcomed. Your SO is used to being berated so he is not strong enough to stand up for you and your family. You need to be the one to put your foot down and stop taking it. I’m so upset for you and I’d have a field day removing this woman from my life if I were you.9
u/Consistent-Tree6802Why are you allowing her to disrespect you over and over again? Madness😣8
u/LindrisYour SO needs to ask himself if his mother could ever possibly bring any good by having a relationship with your daughter. The answer is pretty obvious. Protect your child. Even if it’s from people who are suppose to be family.8
u/luludarlinLoool if someone called me a whore that would have been the last time they’d have seen my face. She obviously doesn’t get any consequences for the way she’s treating you, that’s why she keeps doing it. I’d not want this vile woman near me or my child.8
u/shrimpscampy311You should’ve kicked her out for the whore and bitch comments. Just ignoring it was not the way. I also don’t know why you would want to go to her events or visit her. Your child not having a relationship with her isn’t a loss. She’s just gonna retain the nasty stuff she says as she gets older.8
u/TankDartRopeGirlI think a really good place to approach this from with SO is that you don't want your child to grow up with the same sort of mental abuse as he did. Ask him if that's really what he wants for your child? Does he want them belittled, used in power plays and watching their parents take this sort of treatment which can create a blueprint on what is or isn't ok to accept from others for them in future? Obviously this woman is beyond vile and needs to be out of your life and your kids life asap, but it might help SO to frame it as what it really is, protecting your child and doing everything in your power to make sure they grow up healthy, balanced and with good relationship skills and boundaries. The generational impact people like this can have is impossible to over exaggerate, and he can either let the damage continue, or he can look after his family (both you and baby!) and forge a new, healthier path I hope I'm making sense, and I wish you all the luck. I saw you mentioned somewhere that SO had agreed to therapy, I think that's an excellent idea if it's within your means, he'll have a lot to unpack and he'll need some new tools in his toolbox for helping raise the next healthier, happier generation. I hope you have a really good support network around you also, this is horrible to go through and will be filled with lots of emotional ups and downs. Protect yourself and protect your child, I hope SO can get on board!7
u/Vibe_me_posFirstly, SO needs therapy. He needs to purge her from his life because she is only a source of pain for him. Secondly, I agree that she should not be around you or your child again for all the reasons you stated. The woman is a monster and she will continue to torture her son and will torture your child as soon as they are aware of her behavior.7
u/Electronic_Animal_32You should have thrown her out. You came across as weak. Don’t worry about you child. Better not to be around this b… h. Just keep throwing her out when she’s inappropriate or better yet refuse to see her. It’s gotten to that point already. And keep baby with you.6
u/GirrcollegeLooks like you might have to enter your villain arc. Just tell your SO that you will not raise children around a person that constantly in continuously, disrespect said children’s parents and that you and your child will be going no contact effective immediately. That means she is banned from y’all house too. Be the villain, scorch the earth by nuking it and everything within 100 miles.6
u/brent_bentThat's awesome to hear! Glad you're going NC with her and looks like hubby is heading that way after some time in therapy because it'll teach him she's treating him like shit and the solution to that is to drop the rope not try to win their love by continuing to have them in their life. Congrats on your lovely baby and kicking the witch out of y'all's life.5
u/Otherwise-Wall-6950If SO agrees with you then you're on the right track. Match her energy. She can't get her way and ices you out? Perfect!5
u/Legal-Baby-5130My husband cut out my mil and fil for the sake of our family for similar reasons you described. I think something I find crazy is how people are talking about the rising trend of people cutting out their parents and how selfish our generation is. But I think what's really happening is that we are trying and attempting to fix what's broken and make it better for our kids and families and when no change occurs after multiple failed attempts we just leave because it seems the best thing for the situation. I think if you have really tried and been patient and given so many chances and things haven't improved, then it is often better to just walk away and move forward.3
u/1039198468Understand from an outsides perspective you both should stop engaging with this woman. She brings nothing but stress and she WILL either favor BIL’s child at the expense of yours or undermine your child’s relationship with you when she can. You don’t mention your FIL. Is he involved at all? What does SOs relationship with him look like? Either way while I would support an extremely passive stance I think a more honest approach would be to either call her out EVERY TIME she says anything or NC for all three of you.3
u/642398049Does your SO confront his mother over the horrible things she has called you? That’s absolutely disgusting. I would be having a serious conversation with your SO about cutting his mother out and if he wants a relationship with her he can do that, but not you or your child, I’d be worried about when your daughter is older and can understand words and conversations better, what’s gonna stop MIL from talking badly about you infront of her😳3
u/botinlawQuick Rule Reminders: OP's needs come first, avoid dramamongering, respect the flair, and don't be an asshole. If your only advice is to jump straight to NC or divorce, your comment may be subject to removal at moderator discretion. Full Rules | Acronym Index | Flair Guide| Report PM Trolls Resources: In Crisis? | Tips for Protecting Yourself | Our Book List | Our Wiki Welcome to /r/JUSTNOMIL! I'm botinlaw. I help people follow your posts! To be notified as soon as Professional-Sky-670 posts an update click here. | For help managing your subscriptions, click here. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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45r/VanLifeI’m in HUGE trouble ☹️Isacco23950%9272.0PRP knee treatment2026-03-15↗
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u/man_ohboyDang it sounds like you've had a really rough go at it. I'm glad you're finally getting some help. I hope it all turns around for you. I'm not sure how big of a difference fiberglass vs metal makes, but I lived in my metal van for two years, and with some insulation and a vent fan, it stayed pretty comfortable. I'm in the US, so I have no idea about the laws or options available in Europe. What I can recommend is a cooling option for your medicines. If you have the funds to get a small solar setup (you can likely find a kit of ample size for under 500 euros), you can get a small 12v chest fridge that has a pretty low power draw. You can use that to keep your medication and a few groceries cool. I had a very cheap, very small one (I think it cost $150 new and I bought it used off a friend for $70) and it worked great until it quit on me 2 years later. I probably could've repaired it, but I didn't bother and just used it as a cooler until my vanlife journey was over. Best of luck to you!31
u/Efficient_Raise7695Mi spiace molto per quello che stai passando, dev'essere davvero brutto! Detto ciò, non è vero che non puoi camperizzare un furgone se non passando dalla motorizzazione; a parte il fatto che non ho mai sentito di nessuna multa fatta per "camperizzazione illegale", quello che dice la norma è che non ci devono essere strutture fisse/che non sia smontabile su richiesta di un agente. L'unica restrizione è che devi progettare le cose diversamente, ma è tutto assolutamente fattibile in base alle reali esigenze. Per il caldo, non c'è materiale che tenga, se lo lasci al sole diventerà un forno, devi progettare bene dei sistemi di aerazione che ti permettano di far fuoriuscire in fretta l'aria calda (e umida). Per i medicinali puoi pensare di prenderti un piccolo frigo a 12v.18
u/Nerd_PorterFiberglass is a better insulator, but honestly in your situation I wouldn't hold out for it. Focus on something that will be reasonable to keep that certificate going so you have a stable home. A little solar power and a 12v fan would help a lot to keep the temps down. You'll need a panel, small charge controller, small battery, and a 12v fan. Don't bother with an inverter and an AC fan, wastes too much power. And don't use your van battery so you don't get stuck with a dead battery. As for medicine, get a small cooler. See if you can find someplace that will give you a bit of ice daily. Maybe talk to the morning manager at a local restaurant and see if you can get a cup of ice daily early in the morning, before the restaurant gets busy (or late, or whenever is easiest for them). Just be honest and keep the story short, let them know it's for medicine and you're really in need of some help. I'm sure you'll find someone sympathetic.8
u/imrzzzIn the Netherlands you can build out your own van (it must have certain specifications but these are pretty easy and normal for a camper) and register it as a camper so the road tax is 50% of a normal car. There is an insurance company here that insures the vehicle if you're living in it full-time. I'm only saying all this so you know there are other EU countries you can move to and register as a resident if you want to do a self-build. The Netherlands isn't easy to boondock in though, it is illegal in most council areas but can be done if you are careful. Also, the Netherlands is very far from Italy but there are options!8
u/Lavendercrimson12Where are you? Someone mentioned Italy? If you are in Italy, specifically Sicily, or would want to go to Sicily, message me. I know people there who live a very good eco village life. It would be a good place for you to visit and learn or maybe live.7
u/Visible_Document_376If you cover your roof in a black plastic hose, with a water tank higher than your roof you can cool your home and creat hot water at the same time. Look up solar water heater + thermosiphon.7
u/Visible_Document_376I'm in mexico, it's hot here as well, I ve found that if you can simply keep the sun from heating the metal roof it goes a long way towards a cooler home.5
u/Every-Difference5561If you can get something on amazon, buy a shade cloth to go over the roof on hot days. That will lower the temp by 15-20 degrees. It’s only $10 for a 8x10’piece5
u/Honest-2325Ciao , in che città sei ? Magari in base a questo posso darti qualche consiglio migliore. Buona giornata 🙂5
u/0992673Honestly it sounds like you just need to rid yourself of the van problem and find a cheap shithole apartment, everything is solved immediately.4
u/Angry-CoconutsI see a running theme of “nobody would help me, my mom FINALLY helped me”…. Nobody is coming to save you. You’re on your own. Nobody owes you anything.4
u/mcdisney2001You’ve gotten lots of good comments here, so I’ll keep it short with just a few suggestions. You can get free ice at a gas station by just buying the biggest cup you can find at the dollar store or thrift store and filling it when you go in. I took a 10-day trip with a cheap cooler and this was enough ice to last a few days at a time, keeping the meds I used back then cool enough, as well as some drinks. Can you relocate to a cooler area for the summer? Even finding shade during the day would make a huge difference. I have a great fan I’ve been using for years. I took it on trips, and now I use it in my van. Charges with USB and lasts several days of constant use. Here’s the link. Try adding XPS board (the big purple foam sheets) to the walls and roof. They’re cheap and really do make a difference. And I recently discovered they make Xbox controllers with extra A and B buttons on the back—mine is by Turtle Beach. I don’t have limited mobility, but there’s one game with weird controls that was causing tendon issues for me, and I accidentally found that this controller makes it much easier to play that game. I hope this helps. Please stay safe! I keep a spritz bottle around to spritz myself when it’s hot.3
u/Hour_Gas_36Fiberglass leaks… OG van body is less maintenance.. campers need resealing yearly.. bi yearly if you’re lucky3
u/Visible_Document_376I'm suggesting you put up a solar Shade of some sort, not that you move your vehicle3
u/plastic604I read your whole story, I'm so sorry society has treated you this way. I'm deeply ashamed hearing stories like this, human-to-human. I've been in a van for many years but I have resources. I have spent so much time and money on my build and upkeep of my vehicle, including rebuilding the transmission... I just don't see how a vehicle is the right answer, personally. If I'm imagining myself in your shoes given the story you've told, I would get even more creative than the van. I've spent a lot of time in Portugal and Spain and have come into contact with these communities that are all over if you know where to look.. Between happy-go-lucky hippies trying to make do in very simple ways in these countries, I think this might be your best bet in finding people, support, and basic infrastructure at extremely low costs to be able to sustain yourself. Portugal has free healthcare once you register there. 5 years ago I stayed in communities with my van for 100 eur/mo.. No electricity except my own panels, but communal kitchen, water, showers, toilets.. Even some basic internet and power in the general area. Some people stayed in a place like this in large tipis or caravans that were basically immovable, too. Essentially, I would find a place like this, or a few, try to get in touch with them or go there and inquire, and see what possibilities they might have that may work for you. I'm sure there are ones in Italy as well! For sure on Sicily... I would try to find them by googling, checking off-grid living or communal living kinds of forums or reddits or whatever, marketplaces on WhatsApp or Telegram in the locations, villages, etc that are nearby (you can search for this within the apps). Best of luck and while I can't help directly right now, feel free to DM with any questions or if I can advice on anything <33
u/AxomaticallyExtinctIf you get foil bubble insulation it'll make a massive difference to both keeping heat out in hot weather and keeping it in in cold weather. Insulation is everything when it comes to keeping both cooling and heating simple and inexpensive. So invest in some of that up front and you'll feel the difference forever.3
u/rileyabernethyI'm not sure but a metal van is much cheaper at the mechanics. So sorry about your struggles3
u/Substantial-Today166[deleted]3
u/SlightLeading9203Just my input...I built my own conversion it's not cheap about 12 thousand euros...but i brought the best..as mentioned in another comment 12v fridge/freezer 680 euros...3x 215 watt solar panels and controller..3500watts inverter..2x 200ah lithium batteries all that about 3000 euros...due to mine been well insulated 10mm dodo,25mm insulation board loft insulation again all not cheap...chinese diesel heater (winter)purchased from northern Ireland no import tax ...did alot of research before starting...left bulkhead in No windows just a small roof hatch...(no condensation issues)..lovely and warm in winter...during summer insulation kept van cool till doors open so warm air during night..I brought 2 usb desk top fans kept me cool at night...I lived at my companies trailer yard for 3 years sleeping in van 4 nights a week as up at 2am driving to Dublin...it took me 10 months at weekends to do build...I have really benefited from it.. firstly i did everything myself the build,wiring,tapping into diesel tank for night heater,etc etc...secondly if i go to Dublin i pay about 40 euros to park and the train into Dublin and obviously sleep in van in car park saving hundreds on hotels..plus use van most weekends to get away and again save on hotels. I am just telling you this as to let you know someone like myself with only basic DIY skills can do it and also the time frame and cost...Pm if you would like to see my build wish you all the best...ps i am in southern Ireland (Waterford).2
u/i-PokerIf you're going with a metal van, then cover ALL the metal surfaces with Armaflex - if they're left exposed they act like a radiator. When it's cold they similarly radiate cold directly into the van. 19 mm or thicker on the roof, 9-19 mm on the walls, the floor is obviously not as important. Armaflex is quite expensive (€500-800 for a Transporter/Custom sized van depending on thicknesses used) but easy to install and you can leave it exposed if you don't care about how it looks. Also doesn't mold. Cover the windows with reflective window covers for the same reason as above. With some ventilation this will drop the temp significantly. White vans are cooler because they reflect sun. Black vans are hotter. Fiberglass warms slower than metal and a fiberglass camper typically have insulation in sandwhiched panels. Armaflex in a metal van makes the performance relatively similar, it will just heat up and cool faster. Ventilation is tricky due to your budget constraints. A skylight or some windows will help with passive ventilation. If budget allows Renogy sells a 400W solar blanket that folds up neatly. You can pair it with a small Bluetti power station. It's enough to run a small 12V fridge and ventilation if you're not running it continuously. Will also run lights and a hot plate. Total €830. If you're driving there's also alternator chargers that charges the battery with 800W while driving, so will top up the small power station in a little more than a hour.2
u/Appropriate_Low6575Be proud of the progress you have made. You have taken steps towards your goal while to many of us the van life is still just a thought in our heads. Life throws unexpected problems at us and dealing with them having ocd or adhd can be overwhelming. Do one small thing a day to move closer to your goal and write it down - eg. "asked for advice about the van on reddit". I find decisions to be very difficult especially with ADHD. Since you have the van already I would stick with that. Plenty of people here will give you good ideas to keep your medication from getting too hot. Go with the cheapest and easiest option to start (maybe a 12v cooler) - you can always upgrade later.2
u/Soft-Translator-934I’m in the U.S. and was born and raised in Texas, a very conservative, pull yourself up by your bootstraps state with very little to no social services and even less empathy for anyone in need. It’s also ranked #50 (out of 50) in the states for access to mental healthcare. I was a Registered Nurse at 19 and in my own since 16, and had the terrible experience of being misdiagnosed with Bipolar Disorder at 23, the first time I ever saw a psychiatrist. By 26 I was unable to function, suicidal, the meds they had me on had put me into a very, very deep depression because as it turns out, I wasn’t bipolar. I ended up on disability and spent a couple years unable to get out of bed, merely surviving and completely broke. Social security disability paid enough to pay rent on a small 1BR apartment, but I couldn’t afford my car payment or insurance so had to let it go, was too depressed to take the bus to get groceries, and my family has never been there for me either. Fast forward to me being undiagnosed and given an antidepressant at 29, I was able to get into a halfway house in another city and lived there several years until I could get back on my feet. I started cleaning houses, got a car, and eventually moved to another state. It definitely wasn’t easy, I lived in my vehicle on and off for years, and moved back to Texas a couple times when things got hard, but once I discovered the stark difference between a red state like Texas and the blue state I moved to, I knew I had to get out of Texas for good, and I finally have. I was able to get into “affordable” housing (nothing is truly affordable anymore, unless you live somewhere very rural and I need access to services) and qualified for Medicaid so I could go to the dentist. Access to healthcare in general is like night and day. I was correctly diagnosed as being on the spectrum, and while I haven’t gone back to nursing I did get help going back to school. Things are better now but it took about ten years to leave Texas after the misdiagnosis and I suffered a lot, not knowing the grass was truly greener in another state. I’m not familiar with Italy or how it would work out moving away but I will say that you have options and getting away from the place where you’ve been so miserable is something to consider. I hope this helps…2
u/KQ4DAEAn alminum bodied vehicle is the best for corrosion, I went with a stepvan but its too large for most Europe drivers lisences there should be some sort of similar delivery vehicle that might make a good fit for you. I would avoid any sort of rv or caravan style vehicle they require a ton of external maintince that if not done will cause serious water problems.2
u/Soft-Translator-934If you’re not an outdoors person, aren’t traveling, and have physical limitations, a van doesn’t seem to be the best option, at least right now. Getting indoors where you can take care of your health until you’re in a better place mentally and physically would be a much better idea. Speaking from experience.2
u/tmblweed85To answer your question to the point and simply, Yes, fiberglass campers are better in terms of leaks and insulation but that also depends on the manufacturer. I would not buy a regular van but a fiberglass campers.2
u/BodhingJayIf you arent driving it you can try other options like a makeshift shelter.. hammer, framing nails and 2x4, rockwool insulation and vapor wrapped would do the trick.. Some solar panels, controller and battery, max air fan, water tank and small pump Propane hookups for heating and warm running water A tiny home like this would be a lot cheaper than another junk vehicle2
u/Prestigious_Yak_9004I’m truly sorry you fell through the cracks of the system. From my experience this happens to people whose parents do not do what it takes to help unfortunate youths get a stable footing in the system and to navigate it. I actually lived a somewhat similar life in the USA. We immigrated to USA when I was a child then I had a massive head injury and my parents did nothing except argue, neglect, and abuse us. I developed ptsd on top of the head injury. So I lived almost like an animal for a long long time. Untreated health issues and poverty prevented me from stability. I clawed my way near to stability several times but setbacks happened and I fell back down each time. I’ll stop the sad story here and try to answer your questions. Focusing on solutions is a good way to keep going. Focus on what you can do today to make life better. Ok? I’m an off grid solar designer now. I met someone who helped me learn and and I studied and practiced on my own for years. A basic energy system to keep food and medicine cold is achievable on a small budget. Ive also had good luck with used equipment . It is sunny in much of Italy so the solar gain is good. It was a struggle for years to do it with lead acid batteries but now that LifePO4 batteries are about the same price as lead acid it has become easier. They are lighter, more powerful, easier to maintain, and last longer. You will get more power by buying each component individually over a portable power generator or all in one. A basic 12 volt energy system is a little complicated but it is achievable. Perhaps you can find someone to donate an all in one generator. Try that first. As far as what fridge to buy I have read there are several that work well enough for Vanlife. Ive read many comments of fridges on forums but don’t remember the specific model. Check the reviews of a fridge you are considering. As far as heat is concerned parking in the shade is best. Fiberglass will heat up as but slightly slower than metal. Parking in the shade causes shading on the solar so some people have portable solar panels and place them in the sun while parking in the shade. Can you do this? Finally, fans are a cheap way to stay cool. One expert at Vanlife experimented with fans and solar. He tried many different fans. Some of the computer muffin fans are free or cheap. They make big ones also. He had up to 5 of them running at a time and it made a big difference. They use very little power. It’s possible to also make an evaporative cooler to keep the van, medicine, and food cooler. Thank you for reaching out to the community and take good care of yourself.1
u/jonkolbeI read a post, I think it was here, a few weeks ago about a van lifer who was broke and actually broke down in a Walmart parking lot. Walmart allows people in vans to stay there. He got a job at the Walmart and saved enough money to fix his van save some cash and move on.1
u/yodagoatWhere are you? If in the UK/Scandinavia then present yourself as homeless to the local authority. They'll get you somewhere to stay and begin the housing process. If you are somewhere like the USA all I can do is with you luck and suggest making a double skin "safari" roof to shield the van ftom the sun.-1
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46r/labrador11yo lab with weak legs and arthritis. We think the rainbow bridge is near. Or a...Jackpot5101250%6271.9PRP knee treatment2026-03-16↗
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u/Small-Employee-8123Me personally; I think they’ll tell you when they are ready. Loss of appetite, getting distant from you and others are signs.44
u/Kindly-Box-3957We had to make that decision but our lab was 14. It’s the best decision you can make for them if it’s time. I was told that by a good vet. My heart is with you.20
u/Ace_boy08So when my lab was at that age he was on pain relief for his arthritis which included monthly injections and daily pain relief. We also did monthly laser accupuncture. We also did stretches for him every morning. His bed was off the floor so no cool drafts. He did hydro therapy too and had supplements for his arthritis. Vets told us 2 short walks max a day a 15-20mins. He lived to 13.5 years. The pain relief and hydro therapy extended his life quite a bit. He would have poo accidents as he couldnt make it putside in time but otherwise he was okay. Its about quality of life at the end if the day. If pain relief and other things youre trying are not working and he is in contastant pain then you have to do what you need to.15
u/mcas0509Maybe try some swimming, low impact exercise instead of the walks11
u/N3M3S1S75We tried hydrotherapy and various medications, our lab couldn’t hold himself up and had been like that for months, he was never one to give a hint of being in pain but I know he was. It’s hard to say good bye but it’s harder to watch them fade away10
u/bhoose19RE: Can't get up on his own What kind of floors do you have? If only hardwood, tile or another hard floor, try putting down some non slip rugs for him to lay on. It's much easier for dogs to get up on them.8
u/jackystackLast dog of old age, I relied on a vet visit to the home to determine if he was in any pain. His hind legs were giving out - but he was in no pain. He lasted a few weeks. Myelinopathy, if I recall. Best I can suggest is that if you are indecisive, ask the vet what the humane thing to do is, ask if the dog is suffering and ask for their opinion regarding how these conditions will decline and how fast. Be realistic - given your pup’s age and declining conditions, these aren’t things animals or humans recover from with time. If you want a more measured approach then ask for bloodwork and imaging so you have data to look at — this can sometimes help find resolve in the decision making process. Wish you and pup the best.7
u/DuckieWuckieNLWe started hydrotherapy when our old boy was 11, it helped and keep him active for a couple more years. Most upsetting is when they can’t get up on their own xx6
u/SanjayManbunI sure hope you get more time together!5
u/RoutineComplaint4711The only thing worse than letting a dog go, is not having them in the first place4
u/InterestingDate5459Have you talked with your vet about adjusting his pain management routine? Sometimes when dogs are on maximum doses of one medication like Rimadyl, vets can add different types of pain relief that work together through different pathways. Things like amantadine or certain newer medications might give him more comfort without the heavy sefation you saw with gabapentin. Also, have you looked into assistive devices like a rear harness with wheels or even a full cart? Some dogs that lose mobility in their back end can still have good quality of life when their weight is supported, and they appreciate being able to move around and follow their people without struggling so much. It might be worth asking your vet or physical therapist about options that take more weight off those back legs entirely.4
u/Remote-Jello2136My boy was nearly 13 and had gone lame in one back leg. It all happened really quickly, within 8 months of taking a funny turn on a walk. He had alway been an active boy we couldn’t bear watching him struggling to get himself about we decided the best thing for him was to at goodbye. He was was still eating and drinking but watching him not being comfortable was too hard to bear3
u/Gavidoc02Our older dog is a boxer/shepard mix and is 14.5. Has bad arthritis in his rear legs is slow to get up, I help him up stairs and walk down them in front of him, and he’s on joint supplements and 800mg of Gabapentin a day (for both legs and dementia). He got a bad case of kennel cough and when I took him in I asked the vet that question. She told me to identify 3 things he loves to do. When he can’t do 2 of them we needed to talk. Reason was because they won’t always tell you it’s time.3
u/Downtown-Drawing-825might want to try gabepentin and tramadol, my senior made big improvements from 11-15 years.3
u/No_Bull51Sounds like neuropathy in there as well2
u/SnowblindAlbinoSorry to hear this OP. With our last lab we got just past age 12 and had very similar circumstances, including TPLO surgery. She declined pretty rapidly (like over 4-6 weeks) to the point she couldn't get up on her own sometimes and was shaky enough she started to lose her back legs from under her at times. Also on carprofin. No real complaints from the dog, but it was clear her quality of life was fading pretty rapidly. We also got to the point of fearing our own ability to provide fairly constant care. Once her front legs started failing her we decided that was it. Our youngest was leaving for college and we made a family decision to say goodbye to her before that, which we felt was right for the dog and our family. Our vet was very supportive and while the experience was very hard for all of us, he made it clear that we had done "more than expected" to care for her over the course of our years together. People say "your dog will tell you" but we also have to recognize our responsibility to them. They can't talk. We are responsible for managing their pain and quality of life. Once they are suffering more than acceptable, we have to make the hard decisions for them.2
u/lowlightlivingAs was suggested previously, have a full blood panel and urinalysis done to assess how well his organs are functioning. You’ll want that clear picture. I saw that he’d had imaging done. I would just want that to be recent. A lot can change quickly at his age. Is he still seeking eye contact, pets and cuddles? Wagging? Medical supply stores sell packs of larger than puppy-sized, absorbent, waterproof pads to keep under him when he’s lying down. You wouldn’t have to muscle him outside quite as often. My cousin’s lab had similar problems in his later years. He really missed his walks. She got him a sort of perambulator, kind of a heavy fabric tub on wheels that he could be helped into and still have his long walks - he was happy just looking around, sniffing the breeze, visiting with the local kids. It kept his mind active and stimulated. Something to consider. If he’s beginning to withdrawal, wanting to be left alone - that’s an obvious sign the end is near. For now, there are good suggestions in the comments. I hope you find some helpful. It’s so hard to know when is when. You’ve taken such good care of Jackpot. It’s clear how much he’s loved. All the best to your family in this challenging time.2
u/ikothsoweSorry to hear this OP. We lost Ella to tracheal collapse last week (11 yo) and her big step brother (12) isn’t far behind. He has trachea problems too but his legs are giving out. Ben on Librella fora couple of years, which has helped. But his walks are now 10 mins a day. He’s also developed a fear of the car so we can’t even go to his favourite places. Tried the doggie buggy too but the daft sod won’t get in it. Sad for him because his world has become tiny.2
u/doctordale89My baby boy is 12. He's had arthritis most of his life. Doesn't have the best jump because he has weak legs. Years of different treatments and anti inflammatory pills, we settled on Librela. And he hasn't slowed down at all. He can't run as long but he can run fast for a short period. Don't listen to anyone on the Internet telling you Librela is going to make your dog worse. If he has bad arthritis, ask his vet about Librela. My boy took his first shot of it the month it was available to the public, which was 28 months ago. But I want to tell you this. DO NOT LET YOUR BABY GET THE LIBRELA IF HE WAS NOT ACTUALLY DIAGNOSED ARTHRITIS. If he was I would definitely look at that option2
u/Lower_Cauliflower395When it's time. You will know. You might have more time left than you think..see the vet..maybe some daily pain meds or gabapentin will help. If they're still eating drinking and going potty. Do everything you can to keep them breathing. ❤️2
u/rebelkittenscryHave you consulted the vets and/or a physiotherapist regarding the arthritis? A loss of core strength in older dogs is common as pain makes movement more difficult, same as with humans. However getting the right pain medication and physiotherapy/hydrotherapy to get strength built back up in new ways can help an older dog really live a fulfilling and happy life. But only your vet team and your finances can make that call2
u/ohshethrowsI had to let my dog go a little under two weeks ago. He had CCD (canine dementia). I could have kept him alive longer. He still liked going on walks. He still loved eating meals. His issues were the opposite of your dog’s - physically he was in pretty good shape. Mentally, he had started to become a different dog completely. He was scared and increasingly trapped in his own dementia-world. I decided to let him go when I came to the understanding that my job here was not to wait until all the joy had left his life. Caring for him was hard and his life experience was only going to get worse. I decided to let him go while he still could experience joy; while he still had happiness. I don’t regret it for a minute. For me and for him, it was the right thing to do and the right time to do it. I hope my perspective is helpful. You hold a unique gift which is being able to end his suffering. He will be so grateful to you for his amazing life as well as for ending his pain. Sending hugs ❤️2
u/Typical_Might_1413<image> Ours diagnosed with degeneration at 12 1/2. We let go of her yday with her final breaths (non euthanasia at 15 1/2). Her last years required handheld harnesses, self controlled wheelchairs and towards the very end a pushchair. She was the most beautiful girl we could’ve asked for. So no, it’s not always near the rainbow bridge but yes it was only possible due to a family behind her daily.2
u/blackcat218Talk to your vet about plain old Panadol. My Rottie has bad arthritis because of his bad legs (grew too fast as a puppy). He gets Panadol everyday for his pain. I wont discuss dosages or anything because it needs to go by weight and I can guarantee you my dog is probably twice yours in weight. Speak to your vet though to see if its an option. It has really improved my dogs quality of life. And its cheap.2
u/yrt9610My vet said dogs are really good at hiding pain. Leftover survival tactic. Someone suggested elsewhere: There's a Quality of Life quiz that can help you decide. I'd ask about that on AskVet. And I'm sorry your furbaby and all of you are going through this!!!2
u/Larlo64We brought my 14 year old chocolate in a month ago because I couldn't watch him struggle any more. He was panting and pacing at night and would not walk much anymore. His appetite was always good and he still had lots of tail wags but I could hear him whimper when he got up and if he was outside he'd just lay down and stare at the yard. <image> It very nearly killed me to bring him in but the vet watched his difficulty standing for too long and said it was time. She said labs are extremely loyal and try not to show pain so if it is showing it's significant. I'm still devastated but there's an more sadness than guilt now. Miss you Mr Brown2
u/notactuallyaimeeMy 12 year old had the same reaction to gabapentin (300mg) but is doing well on a lower dose (100mg).2
u/Crafty_Ad3377My guy is 15. His appetite is still full on. He’s lumpy. Has arthritis in his rear legs. Can hardly see. But still alert hears well. Wants to be with us. Sleeps a lot more. But still greets with a front bounce. We have to help him up if he lays down on the hard wood floors instead of area rug. We built him a ramp so he doesn’t have to deal with steps. We have to watch when he goes out or he will head straight for the pond it wears him out. But I don’t think he’s ready yet. He still asks to go out.1
u/aerie2020My soul dog, a chocolate lab who passed 2/26/26, was also on adequan - it’s a weekly injection of 1.5 ml. It only lasted in Ollie for 3 to 4 days so I’m surprised you’re giving it to your dog monthly. When he was close to the end, his acupuncture vet said we could move it up to twice a week, which is what we did. It seemed to help his arthritis. I’m so sorry - this is the absolute worst decision to have to make. Gabapentin also really helped Ollie. And he had twice a week accupuncture and laser treatment.1
u/WolverineHot1886You will know and your dog will also tell you. I know how hard it is but you will know1
u/BonnieH1I'm so sorry you are dealing with this. It's so tough to see them struggling and not feeling ready to say goodbye. I've posted this a number of times in recent weeks. We said goodbye to our 16 year old girl a couple of weeks before Christmas after a few months of illness and decline, even though she was still doing well for her age. We were grappling with when is the right time to say goodbye for a few weeks. When we were thinking through the decision, my sister sent me this video, it's by Dr Mary Gardner a vet who works exclusively with dogs at the end stage of life. (I'm not associated with her in any way, nor do I receive anything if you watch it.) The video is called: How to say goodbye on a good day https://youtu.be/Y2BHOL9g5lM?si=yDxW16Y23XbDUdMm If you want to know what the process was like on the day, I posted that here https://www.reddit.com/r/DogAdvice/s/Fi3yzKt7S5 Enjoy your time with your sweet pup. And when he eventually crosses the rainbow bridge, our Pip will be there to meet him. 🐾💕1
u/whodunnit20We have a senior Labrador who is 12 and a half, she has arthritis in every joint plus hip and shoulder dysplasia. She has had bad arthritis for about two years but it started from young, the shoulder dysplasia she’s had since she was two years old. She only goes for walks about 3 times a week, they are very short. She eats well, very happy but the vets have told us to think about her quality of life. We are taking it week by week, we’ve never lost a dog and it’s terrifying. <image>1
u/ArthurMoregainzI’ve had two labs in the last decade. Lost one right before Covid and the other is still chugging along about to turn 13. Look to invest in some anti inflammatory medicine and pain meds. A lot can be done to improve quality of life and even extend life beyond 10. It sucks when arthritis starts to eat them up but there is hope!1
u/RotflmaocopterAsk the doc for gabapentin. My dog was the same exact age thought the same thing as you. Needed a sling to get him up and walk. Doc said let's try gabapentin and rimidol . Within 10 min he was jumping on the couch again. He is still around 13 1/2 walking fine. Only other thing we did that helped a lot was only feed him royal canine food got his weight down from 89 to 78. Try the meds first1
u/Ok-Sink3939We let our girl go at 11 as well. She was diagnosed with arthritis a few months after turning 10, and while the líbrela vaccine and other medication worked to keep her comfortable for a certain period of time, 2 months before she turned 11 she made a turn for the worse. We took her to a specialist thinking maybe she would need surgical intervention as her regular vet thought she might had some torn ligaments and it turns out she had bone cancer in her pelvis. Hardest decision of our lives, but we are happy that she’s no longer in pain. We miss her everyday.1
u/Chameleon42OMight be worth trying a support brace to see if it eases the pain in the hips/knees.1
u/belladonna1937I have a 13 1/2 yr chocolate. She’s a good weight and healthy. But she has trouble with her legs. Still wants to go for walks and eats like a horse if we let her. She’s definitely not ready yet. She’ll let me know I’m sure1
u/Appropriate-Idea5281If you give your pup medicine for arthritis do your research. We gave our 11.5 year old injections and she had a stroke and couldn’t walk. I regret this every day1
u/MontymistedMy old boy had pretty bad legs for a while but still wanted his walks on the soft grass for like two years until a lump in his throat finally forced us to say goodbye.1
u/GoMineBitBossYumove maxi for senior dogs worked wonders on my partners 8-year-old lab with arthritis she is like a new dog. <image>
u/Thespian_UnicornGot a puppy and it extended mine’s life by 4 years.-3
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47r/CATHELPPotentially abandoned cat on my road - any ideas what could be wrong with her?doubledenim30001900%3471.8PRP knee treatment2026-03-17↗
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u/LieuNeverLiemaybe worms?3
u/meeshvall3Hi, you can claim you’re watching a friends cat due to an emergency and find a humane society clinic or rescue to bring her to. They will take care of her and find out if she’s microchipped/missing. Please take her in, find her help, and don’t regret being a sitting duck. If you’re in the NYC area there’s a great place called PuppyKittyNYC2
u/agata_30Take her to the vet. Probably worms + ringworms2
u/Safe-Sail9335VET. ask the Vet. Let us know. It could be fleas ,mites ,allergies ..help her please!2
u/Massive-Beyond-336Use neosporin, it works good on cats1
u/MarciefordIn this picture the cat looks completely normal. What am I missing?1
u/joyarepYou’re so kind to help her.Good luck.1
u/ClasherChiefJust in case it is parasites, it wouldn’t hurt to buy some topical anti-parasitic medication that will work on both interior and exterior parasites. Get the kind you apply to the back of the cat’s neck, it shouldn’t be very expensive and it’ll be available at pet stores.1
u/polishatomekI'm not super knowledgeable about cats, but does she seem like she's in pain? If so I'd probably try to at least get her to an animal shelter. The spot in the third picture doesn't look like pregnancy to me. (But I'm not a vet so I might be wrong) I think she might be abandoned because no sane person would leave their cat outside in this state1
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u/Massive-Beyond-336she looks pregnant
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48r/VAClaimsHow to write a good lay statement (based on 66,000+ analyzed cases)EdgarAllinPump1590%4071.5PRP knee treatment2026-03-09↗
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u/Icy-Kaleidoscope3038Thanks for all this...then I saw the link and the words "free demo"...and all good for hustle and business, but I've seen and talked to enough folks who have signed onto groups that require compensation or take a cut...14
u/joysboxTotally agree about the Buddy statements! I hope your post is really read and digested by our Veterans for their claims. Wanted to say that your first example about Rheumatoid Arthritis isn’t really how RA usually shows up medically. My husband has had RA since around 2012, so I’ve spent more time than I ever expected learning about how this disease actually behaves. RA is systemic autoimmune inflammatory disease, and the joint swelling and stiffness are usually persistent and often symmetrical, especially in the hands and wrists. The morning stiffness can last an hour or more, and the inflammation tends to stick around rather than popping up for 2–3 days and then disappearing. Your example sounds closer to is Osteoarthritis, which is more of a wear-and-tear / mechanical joint issue where symptoms can flare after heavy use or stress on the joints. Just my two cents. Thank you for your information!7
u/Useful-Zebra-5657Lay statements mean almost nothing if it is not supported by the evidence of record.3
u/Direct-Humor-8622Thank you for sharing. It is information like this that helps veterans.3
u/Jazzlike-Ear-7485Question for you? I was about to sign up and I’m reading the disclaimer - The free account will provide “Demo Mode Access” to realistic claims information. So - is the data based on real appellate cases from BVA and CAVC? Or is it simply modeling hypothetical claims and conditions? Looks like an interesting tool - great potential.2
u/Captin_CavemanFollowing for information2
u/Miserable-Ad7079This may be the most useful post I've ever read. Thank you for taking the time to explain how important your lay statement is and how to best word it. I've got a few to get done soon and I'll be saving this post and using your link.2
u/BothCalligrapher3842Very interesting and sounds solid2
u/RumblejeffAlways include a lay statement!2
u/Background-Season213Hmm, I wrote out my personal lay statement, not good. Used Chatgpt.com was much better. What is different? Why should I use Raven when I can easily use Chat or Claude ai?2
u/Used-Independence182Amazing post2
u/dolphfanmanI believe that lay statements ( personal, family, and buddies) mean more at a BVA judge decision. However, too many CP examiners ( nurse practitioners) summarily dismiss positive outside evidence and look for simple, on-point STR medical evidence . Some are more “totality” of All evidence but most are “nothing is reflected in STR” and a “not as likely SC.” Afterwards, the “Raters” undoubtedly look for the negative marked box and deny. Rarely, do the Raters read lay evidence, and consider other factors mentioned in the claim for a broader equipoise opinion. My opinion. These are not 100 percent but you would be rich in Vegas taking these odds.1
u/Calm-Proof3577AI slop SPAM is what the post amounts to.1
u/Pure-Parsnip-1757Sounds amazing. How does one get access?1
u/Omega10115This is great information. I plan to take a look at my claim submission strategy to make sure it correlates to the information you presented. Thank you much!!1
u/Beneficial-Tank-3477You should also always do a statement with headaches/migraines. The exam is set up so that if the examiner doesn't think you have migraines, they won't say how frequently you get headaches. You need to say how often you get them1
u/Mike-A-FInteresting. I feel like you might get ripped here but I think its important to build out tools for people to help get thru the process. I may give it a shot in my new claim to test it out. I’ve been going back and forth w different LLMs & looping into contradictions when i go too deep.1
u/CandieCummingVA is using Ai more and more. With proper prompts and clear communication and interpretation of your evidence and symptoms you can use AI (I like Chat GPT and Grok) to properly construct statements and then edit them that pass the VA Ai but you still need to be able to articulate them to the reviewers. The human element is as critical as the AI formats so put in the time and effort but use all tools available also. No need for purgery or embellishment. You got this.
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49r/AmazonDSPDriversAmazon's DSP Program Doesn't Just Exploit Drivers. It Was Built to Eventually Di...Universaltruthx890%8571.5PRP knee treatment2026-03-28↗
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u/jboy4000These ChatGPT essays have to stop. This isn't the first time you've done this and it's getting sad at this point.98
u/Ok_Guava6350ChatGPT or not, this is very accurate. I can tell you that those bonuses you are referring to that are supposed to trickle down to drivers? Amazon has pushed so many expenses onto the DSPs that they can’t break even without at least being in Fantastic. To make matters, they’ve also increased the difficulty in achieving said bonuses.27
u/CMUpewpewpewFuck this AI slop i aint reading all that.14
u/JB_7799DSP owner here. ChatGPT or not, this is spot on. I’m repeatedly asked what it’s like to work for Amazon. My reply is always the same. Imagine every week you received a 10,000 question test and if you got five answers wrong, you don’t get paid that week Drivers have received over a 30% raise since our launch while amz continues to reduce our compensation. They say they’re raising it, but then they make you pay for something else, or make the scorecard harder to get so that you never get bonus. I’ve heard senior leadership lie to a room of 1000s of DSPs. After a while you tune them out. Every single Amazonian I’ve ever met in person are great people. They work hard and they try to fix problems. Unfortunately, I’ve never met anyone with the authority to actually fix a problem. I own other businesses and if I see an issue, I can fix it immediately. It’s sad. I’ve got a good staff, we do the best we can. We try not to be too hard on the drivers because this is a hard job for you all. I also realize it’s a relatively good paying job for the skills required. Most people working for me don’t have a lot of other options. I’m not gonna fire you because you accidentally ran one red light, but Amazon might. Yes, DSP owners can make money. But it’s not a lot. But it’s about how you manage the business. Your overhead, additional staff on site, extra rescued, accidents & what you’re forced to pay for out-of-pocket. If you work for a DSP that’s doing less than 30 routes, the owner isn’t making much more than you as a driver. But what makes things worse is that most of the initial DSP owners were entrepreneurs with a lot to give. Especially give their employees. And 99% of the time, our hands are tied. One of the worst things that I see, and try like hell to avoid, is buying into the Amazon philosophy that people are just a commodity. That weighs on my soul.11
u/Sensitive_Macaron767Well yeah, of course. Amazon has maximum control with no liability. Drivers still have to follow all of Amazon's rules and do everything Amazon tells them to do, but the responsibility of all individual disputes with customers are on the shoulders of the DSP. This is beneficial for Amazon for multiple reasons. Saves them from having to pay someone to handle disputes and second, it benefits Amazon greatly when DSPs dont perform well. If a DSP does not hit fantastic+ they make no money for the week, usually they will lose money. Same with lawsuits. Oh a driver crashed his van into a car and killed someone? Its on the DSP to handle all of that legal work and Amazon doesnt have to have any part of it.11
u/ihandoutsmokeAmazing. . This is so spot on .11
u/UnfaithfulHorse“ChatGPT, make me a well thought-out essay on the implications of Amazon discarding DSP businesses as a linear comparison to how Amazon treats individual drivers so that I can karma farm on reddit” Do you really expect us to believe you wrote this?7
u/Longjumping-Series76Not reading all that5
u/redskinfan654Are you a bot?5
u/dingdongjohnson68I was very reluctant to read this because of the length (that's what she said), but am glad that I did. Very informative and surprisingly easy to follow/understand. Why are so many people here "concerned" that it was written by chatgpt? Who cares if it was? I'll give OP the benefit of the doubt that they did write it. I am frequently on this sub bitching about amazon's unfair, bullshit practices. It is often difficult to not get mad and upset at my dsp for some of their practices. Sure, I'm sure they aren't "perfect," but I truly believe it is a case of amazon "putting the squeeze" on them, and then the dsp pretty much being forced to put the squeeze on drivers. How does the saying go? Shit runs downhill? So basically, I blame amazon for roughly 93% of the "bullshit." I realize dsp owner's are also in a tough position, and surely have a lot more to lose than I do. Like, I've heard when a dsp gets shutdown, that amazon "sends the owner a bill" for like hundreds of thousands of dollars for van damage. Not sure if that is true, but I somehow doubt amazon mentioned that when recruiting potential dsp owners. I don't know. Are dsp owners' personal assets protected by them being an LLC, or whatever? I don't know much about "business." One saving grace for drivers (if you can call it that) is if a dsp gets shutdown, the number of packages going through that station stays the same. So most drivers should probably not have too much trouble getting on with another dsp.... if that's what they want to do. Just look at the driver turnover rate. I don't have any official numbers, but I know it is fucking insane. The vast majority of people either can't, or just don't want to work as hard as this job requires. Not to mention the ever increasing pool of people that are so addicted to their phones that they wouldn't even consider doing this job. I'm sure we all see amazon drivers frequently. It LOOKS like an easy job. They're usually just stolling around. Usually carrying an envelope or a small box. Yes, the vast majority of deliveries ARE technically "easy." The difficult part is the repetition and the volume. As OP stated, there is no "slack" built into the routes. It's going nonstop all day every day. For me, I think the worst part is getting in and out of the driver seat 300 times per day. Tough on my lower back. The electric vehicles are actually much better about this because the seat sits higher up off the floor. But yeah, jumping/climbing in and out of the van hundreds of times is also taxing. Not to mention loading like 1000 pounds (maybe more?) into the van in about 10 minutes and then carrying that 1000 pounds (generally a little at a time) over the course of walking 10 miles per day. Anyway. Hopefully things improve significantly, but I don't have my fingers crossed. These days in particular, I don't have much confidence in our "institutions" to stand up for the little guy. I fear that amazon may be too big, rich, and powerful to fight.5
u/delksonPretty much facts, some of yall needa know gpt is used to edit and fix shit all the time. My current job we literally use gpt to translate.5
u/nOzAmA191[deleted]4
u/Outside-Cellist-7624Biggest thing is the bonuses do not get handed down to the drivers honestly it goes into the dsp owners pockets4
u/mediceman33Oh the beauty of capitalism, got to love it.3
u/Valuable-Condition59How many gallons of water were just wasted to repeat what’s said on the sub daily and pretend it was investigator journalism?3
u/CriticallyThink23This has been known.2
u/Ok_Armadillo_9814Was genuinely insulted by the program2
u/Real_Reflection3510I ain’t reading all of this but the title is incorrect, it was built so Amazon doesn’t have to be the employer, to avoid all legal scenarios2
u/SquirrelInATuxThe NLRB already ruled that Amazon and DSPs are both dual employers of DSP drivers. Amazon appealed this ruling to the courts and was denied a preliminary injunction last February. Then, just recently in December, their appeal was rejected by the 9th circuit court of appeals, where the court stated that the they do not have jurisdiction to overturn pending NLRB rulings under federal law. This means the ruling by the NLRB will be moving to binding guidance soon. Source2
u/br9897Our dsp closed a couple of weeks ago, my fiance who was one of the top drivers at the dsp and never got hit on netradyne cannot get hired at other dsps because of 4 misdemeanors from 3 years ago(all $100 fines). The misdemeanors in question? Her ex let her horses out while she was at work resulting in them being at large. She has a perfect safe driving score in Virginia with her only things on it being non moving violations. The "accurate" background check has flagged her and she received an adverse action notice. Even the dsp owner she applied for has been trying to get Amazon to push it through. Meanwhile, 4 people from the dsp who I know have several drug related felonies and misdemeanors and one with felony assault have passed the background check. Make that shit make sense.2
u/lucky-struckThis is the most thoroughly well-conceived, thoughtful, and comprehensive picture of the DSP system I have seen in my years of watching this forum. It speaks directly to the heart of what's truly causing all the daily frustrations we see posted here, and it's that all parties involved from the DAs to the Owners to the Amazon OTR staff, are active participants in a system that passively dictates authority and delegates responsibility. Each of these bullet points is worthy of its own journalistic investigation as part of the big picture presented here; that sustained success is impossible as a function of this system's design, and no one is accountable for failure until they run out of scapegoats.  GPT-assisted or not, these thoughts are self-evidently from human experience and it is well worth everyone's time to read through it all.2
u/This_means_lore“If these people could read they’d be very upset”2
u/Different_Wallaby660Excellent read. The courts need to bust Amazon down a peg. They’ve gotten away with this bullshit for too long. Peak never ended and we don’t get bonus money unless we meet ever changing metrics. It’s all a lie and we get screwed.1
u/VxctnI mean duh. You're five years old if this is news.1
u/Turtle0550Bro we gonna need a TLDR1
u/_x_Deadpool_x_Tl;DR1
u/TastyExpression8465The public sees damage on the outside of the vehicle but the damage internally is monstrous. In almost every company I've worked for the check engine light is on and has been on for years. Things aren't fixed unless they absolutely have to be, such as Amazon grounding the vehicle for it or the damage simply keeps the vehicle from running safely. Even then they'll still push it out onto the road just to have a route covered. I was flat out told by someone that a vehicle doesn't get sent out because of how bad it runs and is. Guess which vehicle that person gave me every day ... during the winter. The public, or authorities outside of the loop, have NO idea just how bad the vehicle situation is. Few step vans can actually pass standards. Few vehicles could pass safety inspections. Hell. The power steering was out in a vehicle and they STILL kept sending it out onto the road. They will willfully destroy, permanently, a vehicle just to get routes covered. Another company I worked for would pull vehicles out of a mechanic shop just because they needed it .. before it was even fixed. Forget the grouped stops or pay not matching the workload. The business by design is incredibly dangerous to both the public and the drivers. There is no path to report this shit. There is no path to make it stop, and I'm pretty sure Amazon knows about it too. I'm not the first person to bring this up and I won't be the last.1
u/lilbargazerNice AI post1
u/caeseronEverybody already knows this.1
u/theretrogamerbay1
u/dtaylor72123If you had to study to realize this…1
u/ChocoQueen1RIR ! get with the program it always and still will be amazon smh. its just easier for them to have the dsp take the fall and lose their business 🤷🏾‍♀️1
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u/Glass-Celebration230Ok
u/CriticallyThink23The problem is that none of the drivers, or the DSP owners want to Unionize.-1
u/ImportantDay5697Someone that gets it.-1
u/dingdongjohnson68Ditto-2
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50r/ValueInvestingAvoiding dumb mistakes might be more important than following good rules in inve...RawDogStudios1340%4671.2stem cell therapy2026-03-15↗
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u/ColForbinClimbsCapital preservation is key29
u/CompoundQuietlyGreat thought. You've hit the classic Munger philosophy - think about what would cause failure and then do the exact opposite. In his words: "It is remarkable how much long-term advantage people like us have gotten by trying to be consistently not stupid, instead of trying to be very intelligent"12
u/DaveFoSrsDon't invest in a business you don't understand. Don't "figure out" what a company does from its shills on WSB and Stocktwits--they have a vested interest in duping people. Avoid small cap stocks, especially if the above it true. Don't invest pre-revenue or pre-cash flow positive Source: I was a moron in my 20s9
u/mrmrmrjMinimize losses. Sell losers quickly. You can always buy them back. There seems to be a psychological resistance to selling a stock after owning it for only a month or two if it is down. I don't get this.4
u/Q16QGreat to see someone think about fundamentals. You have a better chance of succeding.2
u/Few-Perspective4430Good point. In investing, sometimes the biggest wins come from simply avoiding bad decisions. Many people chase hype without understanding the business or checking the fundamentals. Sticking to what you understand and avoiding obvious red flags can save a lot of money in the long run.2
u/Hamzehaq7totally get what you're saying. it's wild how many people jump into stuff without really digging into the basics. like, sure, AI is hot, but if you're looking at companies like Oracle with that kind of debt, maybe take a step back? lol. sometimes it feels like folks want the thrill of investing without the actual work. it's all about balancing enthusiasm with common sense, imo. avoiding those super obvious red flags can save you a lot of pain later. what’s your take on the whole AI hype right now? seems like everyone's trying to chase that next big thing.2
u/CherryRoutine9397Avoiding dumb mistakes honestly does more for your money than trying to find the perfect strategy. Most people lose because they chase hype stocks, overtrade, or copy random portfolios they saw online. Keeping things simple and actually understanding what you own already puts you ahead of most investors. I write about stuff like this sometimes, link is on my profile if anyone’s curious.2
u/Dependent-Panic-9457I agree with the point about debt. I am nonetheless up to my neck in Jadestone Energy. Actually: above my neck.1
u/BCECVEgive us more. thx1
u/CalendarNo6655I actually genuinely enjoy reading and learning about these companies. I think big pharma, nvidia, or biotech is really interesting though investment wise they are not ideal. I think there are some 10/10 companies but they rarely go on sale. Unfortunately the market prices them too well1
u/jay_0804Avoid obvious mistakes first. Examples: Snapchat never profitable, Tesla P/E 363, Oracle high debt. My rules: long profitability, decent ROIC, understand what you own, low debt, real moat. Avoid dumb errors before chasing perfect setups.1
u/One-Event6199Someone on this subreddit who actually has useful thoughts/insights. This is so spot on. This is Buffett/Munger/Lynch in a nutshell.1
u/Lost_Percentage_5663Most ppl are IQ100. But they think they are IQ110. All tragedies happen with it.1
u/AInotGLesson: If it is being discussed publicly, probably it is already overpriced-3
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51r/singularityIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz740%26271.2regenerative medicine2026-03-10↗
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u/ImmuneHackThis is the kind of reductive thinking that plagues discussions about AI and the future: imagining extraordinary breakthroughs in one area while assuming inertia everywhere else. It leads, paradoxically, to imagining a civilisation advanced enough to solve ageing while importing all of today’s limits in every other domain into that future vision of the world. To be clear, my point is that the same breakthroughs required to solve ageing would probably coincide with major advances in automation, robotics, land management, energy, agriculture, desalination and food production. Meaning that population control in such a future might not be as much of an issue as it appears from today’s vantage point.114
u/H_A_A_K_O_NYou still need new people. A lot will die from accident, murder, wars, suicide.63
u/CryptizardIf every human is allowed to have one child then the population will stabilize at exactly 2x its starting level. If we have the tech to cure aging then we can definitely support 2x the number of humans, so no problem.47
u/Appropriate-Tough104If we get there we’ll probably also solve energy and space travel so can expand our species to other habitable planets18
u/rlanham1963None of us know what even advanced AI will do to life in 5 or 10 years. Speculating on massive social events like an end to ageing is effectively impossible to do with any foresight. We are on the cusp, even without ageing change, of the greatest social change ever. And no one knows nor understands the implications of dramatically less work, dramatically less cash flowing, dramatically lower real estate values as investments, etc. etc. These things have never (ever) happened before. One looks to things like the Black Death or the rise of modern public health medicine (mostly chlorinate water) to see equivalent changes to even begin to compare. And those are not close. Watch programmers. As they go away (and they are) you will see, first, peak employment, then peak despair, then acceptance, then change. How? Implications? The smartest and deepest thinkers can only guess right now.11
u/blueheaven84Not having kids is a small price to pay. I hate that people aren't sure between 1. having kids and 2. NOT DYING10
u/FiresideFox05I really think that the ‘eventually’ there is doing a lot of very hard work. Odds are this shit would only be available in modernized / industrialized societies, and half of those are working their way to a slow demographic collapse, East Asia in particular. It would take South Korea or Japan hundreds of years to reach any meaningful degree of overpopulation if the old people stopped dying; by then, it’s seem as if the planet or perhaps the solar system would look so different there’s really no sense bothering to infer about it.7
u/Virtual_CrowIf average number of kids is less than 1, then no. If the number is 0.5 (average couple has one kid, and all their kids' couples have one also etc) the population only doubles eventually. With random accident mortality and the trend of people to not have kids as they get richer, it's probably not an issue.5
u/peterflysI think we’re forgetting the prospect of transhumanism and posthumanism. Why would we stop at biological longevity? We won’t. Once we figure out how to interface our brains with AI, we’ll move our consciousness out of our bodies. Biological breeding will stop.4
u/ioneticLaughs in microplastics.4
u/MisterBilauIf we can completely cure aging (as in biological immortality, not just extension), we will have the tech to expand to other planets. Probably easier to do, actually - we kinda know how to do it already, it's just a matter of resources, whereas we're very far from achieving immortality from a tech standpoint. Then "overpopulation" will be a non issue.3
u/oadephonIf there's enough abundance in healthcare to solve aging, there will probably be enough abundance in everything else to support a growing population.3
u/GreasyRimFrankly, it looks like we're becoming uninterested in reproduction, at least in the US.3
u/Strange_Sleep_406lol lmao even3
u/bigdipboyNo they’d just sell immortality to the super rich and everyone else would still die3
u/AcrobaticKittenAs far as I know if you'd cure aging the lifespan would be 500 years max, even though aging is stopped life threatening risks are still there.2
u/NegotiationWilling45This problem will have any number of currently unforeseen factors that will impact the answer. It won’t be today’s world at that point.2
u/ziplock9000What they did in China would have to happen. Assuming we don't vastly increase technology and put bases on other planets.2
u/SmugPolyamoristThere's a lot of whatif's to consider. A few are; Fertility rates in developed countries are already heading well below 2. Would this reverse? Perhaps, if you're eternally youthful. Will the fertility rate trend be reversed by selection pressure?(orthogonal to your hypothetical really) Is a society where we've cured aging but not expanded into space or massively densified earth likley?2
u/[deleted]With AI and most likely super abundance, there would be no reason to ban reproduction. Also, we won't have governments run by humans anymore. Plus with the advances in robotics and synthetics, we probably won't even need biological bodies anymore. That would also cure aging. And as another commenter said, with the advances in tech we would probably expand our species out into the stars.2
u/ExoTauriWe're gonna need a shit ton of people to be able to populate the solar system, so no.2
u/Virtual_Plant_5629i'd be really curious what kind of timeline has it taking until 2050 that's an insanely long time at the current rate of advance. even without AI that would be a really long timeline. with ai.. it's an eternity af2
u/TheRebelMastermindThey will ban reproduction as soon as they find out how to make that happen in shit countries. Regardless of aging2
u/StahlbodenBirth rates are declining accross the board and children are sort of symbolic immortality so with cured aging, people would have even less incentives to make babies. Adding to this the fact that deaths unlrelated to aging would still occur, and we might have sort of a balance.2
u/MeasurementOwn6506The peons of the world will have been made artificially extinct through various initiatives i.e. another COVID, chemicals reducing fertility in foods and other means. So this won't be an issue2
u/Stamperdoodle1If humans ever cure aging - The only thing that would happen is the ultra-rich would live forever. Our lives would not change at all.2
u/PulselovveWhy wouldn't they want to share the cure with you? What is their incentive?1
u/zombosisThat would only be for the rich1
u/RonocNYCIn a world of ASI human reproduction would be pretty tightly managed as it would be in a game reserve or zoo and that's probably being generous about ASI alignment.1
u/0sko59fds24By that time we are either multi-planetary or extinct1
u/1a1bPopulations in developed countries decline without immigration. Increased longevity would mean countries can reduce immigration while still maintaining population growth.1
u/Some-Habit-1428Read Scythe by Neal Shusterman1
u/clandestineVexationCure aging but not death. Statistically most people die before they die “of old age”, that’s why it’s a population pyramid and not a population rectangle. People will still die of other causes even if biologically they could live in perpetuity. Maybe it will balance out and solve the western birthrate crash problem1
u/New_Public_2828Aren't they trying to do that now indirectly? Puts tinfoil hat back on1
u/Important-Figure-512I think people would need to kill themselves because who the fuck wants to live forever that’s like torture1
u/ThrowRA-footballWith better technology we could easily have 200-300 billion people without it impacting the environment too much. Green Energy will make pollution go away. Better food production will feed a bigger population. Better Robotics and resource extraction will give us an abundance of raw materials. And using Arcology type housing could house a bigger population.  And this is assuming we don't colonize any other planets ever, and don't also create artificially more living spaces on earth or anywhere else. This will give the world a population density roughly equivalent to Japan. So a bit more densely populated but still having lots of green spaces. This doesn't even take into account the dramatic dropping of birth rates around the world. I honestly think we won't even want to think about implementing any population control measures because of the dropping population. Curing aging might be what saves humanity from going extinct.1
u/Luvirin_WebyMost likely no need to ban. As there is basically no lack of land, earth vcould support easily 10 times the population and the solar system a million times and people do die even without aging and so on. There might be limits on locale at some times... Also I am not sure everyone wants to live forever, I mean I do as there is always something new to learn or experience, but I have heard many people voicing things that they do not want to. As for inequality: Things tend to swing in that regard, as we went from the robber barons to the much more equal thing after ww2 to current technocratic elite, so future swings in the opposite direction are again likely.1
u/pink_gobletthe level of bio-engineering and molecular precision required to halt senescence typically implies mastery over matter itself. you would solve many other issues affecting climate and greatly increase the carrying capacity of the planet by orders of magnitude.1
u/cfehunterConversely this means we get to keep all of our greatest scientific minds. It means the complete abolishment of the pension burden, you really will be able to work until you die. Whether that's a good thing or a bad thing depends on whether you enjoy what you do I suppose. A lot would need to change, absolutely, but outlawing reproduction isn't likely. You'd be immune to ageing, not death. Sooner or later, we're all going, no matter how good medicine gets.1
u/NotAnotherEmpireWith current birth rates in advanced economies, that seems unnecessary.1
u/LymelightTOWe already live in a world where the TFR is precipitously dropping as people in developed countries choose to delay having children later and later, sometimes indefinitely, as they exit the fertility window. If you cured aging, presumably making the fertility window indefinitely long, I would expect people would choose to defer having children much longer. Also, this assumes addressing aging happens, ceteris paribus. If we’re curing aging, we’re likely resolving scarcity altogether, shortly thereafter. I wouldn’t worry about overpopulation, no.1
u/MasterDisillusionedThey wouldn't have to, they'd just cull the rest of us.1
u/SilverDetail2713We can't even solve male pattern baldness. There hasn't been any real breakthrough in medicine this century... If we'll be able to keep the pace finding new antibiotics to fight super bacteria, be thankful...1
u/Whispering-DepthsDon't be silly. If we cured aging, it would be in a matter of less than a decade, not 25 years, and it would imply advancements and innovation that make that a non-issue. Solve our need for food and our ability to not re-use waste in general, and start growing vertically in both directions, and we can support exponentially more humans if we're stupid enough to keep everyone on Earth exclusively.1
u/HotKarldaltonAnyone else watch Mr. Nobody? Very fitting movie for OP's post.1
u/hideousoxWhen humans ‘cure’ aging in 2050, the cure will be available to the ultra rich. The rest of us will keep dying, even younger, while we throw turds at each other, blaming our neighbours for our ultra rich inflicted troubles.1
u/Ok_Height3499Oh, I hope so. They ought yo do it now.1
u/Professional_Dot2761Our solar system is pretty big and humans uploading is the step after lev.1
u/djkool_yankyYou need to pay for life long subscription fees to the governments. Starts at basic - diseases cannot be avoided. Premium - no diseases.1
u/MJM_1989CWUWe will need more people to colonize the stars!1
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52r/VentHealth Insurance in the US is a JokeRarely_Informative1260%4671.0PRP knee treatment2026-03-23↗
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u/markallanholleyI got a letter in the mail about COBRA when I left my last job. I didn't even open it. I don't have an extra $2K a month lying around.27
u/CarefulAdvice3739Ice, Advil and a knee brace helped me get through a torn meniscus for over a year..... Even with surgery these injuries take time to heal up.20
u/Infinite-Ask-7285Did you tweak it on the job? Like wink wink did you say do it that same week? And I could not agree more about Cobra. WTF is the point with that shit. Good luck to you. I do not pray, but I will think of you.16
u/FatCowsrus413Check with Medicaid. You’re unemployed before you start your new job. You may be able to get emergency coverage5
u/TrueMeaning4241It does seem like a joke to pay high prices every month so that in the off chance that you get hurt you don’t have to pay even higher prices on the bill to get better.❤️‍🩹4
u/WorkingCollection562Where do you live? You can try Mexico? They have cheaper health care options and I would argue sometimes better4
u/Biteme75I injured my back at work but didn't claim it in time. Apparently, you have to tell them you're injured when you still think it might be a pulled muscle, or you're lying. Fortunately I had private health insurance at the time or I would still be in debt. I no longer have health insurance because it's become three times as expensive in the last year. If anything happens to me now, I'm f*cked.3
u/Ill_Lifeguard6321What do you mean?! I love that my healthcare companies are making billions and billions upon the death of my American brothers and sisters! Trickle down economics am I right! /s3
u/Mental_Signature_725My neighbor tore her knee up a few weeks ago. Her self pay for an mri was $300. Thats cheaper than my insurance co pay. The doctor agreed to do the surgery for $1590 cash self pay. Start calling and asking you might find its cheap to self pay.3
u/sjayveeHospital has to treat you even if uninsured. They should have a program where they will help you apply for Medicaid if you’re uninsured. But yes, healthcare in America is seriously broken.2
u/Rarely_Informative[removed]1
u/climbing_butterflyMarketplace?1
u/PNW_OlLady_2025Go the drug store, get a knee brace, some ibuprofen and ice packs. If it's your PCL or ACL you can you walk it on it for a good long time without doing any more damage, just give it the extra support it needs. Surgery is not always the answer for these, especially if you aren't an athlete or laborer of any kind. As for our insurance being a joke, I mean, that 3 month wait you'd have for that MRI in the UK or Canada is about the same time you'll wait for your new insurance to kick in. Or, now hear me out, get a job with a better company who's health insurance kicks in on Day 1.1
u/No-Firefighter3283I grew up with great National Health care. Did not pay for anything ever, not even medications. Moved to the US and all was good while I was younger, then 2 c-sections and a serious hospital stay forced us to file for bankruptcy. 2 professionals with good jobs and between healthcare bills and daycare, we just couldn’t do it! The fact that US healthcare is tied to employment is insane and I’ve no idea when this became a thing. I knew someone whose teen daughter has serious health needs and was on his work’s health insurance. He could not move up the ladder in his career at the time because her pre-conditions would have prevented her getting any healthcare if he took a better position at another company. Then there are the jobs where the insurance covers very little but the employees premium is still high. The worst is zero hour contracts to avoid having to offer healthcare to employees, which is just diabolical! The thing is, a healthcare for all situation would actually cost us less in taxes than the premiums and out of pocket expenses. But, Republicans especially get donations from private health insurance companies, drug companies etc, to keep us all fearful of universal care, so they can keep counting the gold in their vaults. Growing up with free care, the lies politicians spew to scare us, makes me sick, so many suffering for the very few at the top to make bank.1
u/piranha_Yeah…😕 You’re doing everything “right” and still stuck choosing between your health and your finances, which is insane. A lot of people end up in that exact gap period between jobs where coverage just disappears. One thing that might be worth looking into if you haven’t already is calling imaging centers directly because some offer cash or self pay rates for MRIs that are way lower than expected if you ask upfront, same with ortho consults where they can at least get you a diagnosis or plan without blowing up your budget. Not a perfect solution at all but it can at least help you get clarity instead of just guessing and hoping it heals. That situation sucks though man1
u/whoocanitbenowI pay 170.00 per month. I have to pay 100% out of pocket until I reach 7200, then my insurance actually kicks in.1
u/Sunny-DamnIn my state we have a “spend down”… maybe yours does too. If you rack up medical bills, in your name, and they exceed 25% of your annual income, the state will pay the bills (only retroactive for 6 months) and give you health insurance for six months. It might be worth looking into… MRI’s are not cheap… This is what paid for a stroke, a heart attack, 3 leg amputations, a finger amputation, and a rod placed in a spine in my family. We’re chronically uninsured.1
u/purplepeopletreaterCan you apply for Medicaid? How much is it to pay for the MRI and PT out of pocket? Call around and find out what the self-pay rate or discount is. I would not recommend just walking around on anything torn. It could cause you permanent problems.1
u/[deleted]Sure is a fucking joke.1
u/OkInvestigator7893i'm so sorry you are going through this. i'm self-employed & the only insurance i can afford covers nothing. i haven't had a primary care physician in years because i kept getting on someone's waitlist and then they'd leave the practice before i ever got a first visit. i've accepted that i have medieval peasant care at this point: if it's bad enough to kill me then i guess i'll just die, otherwise i'm figuring out home remedies and self-medicating as best i can. luckily i don't have any family or dependents, i don't know how i'd navigate this horrible system with kids.1
u/PlatypusMajor3032Unfortunately it will not get better, only worse, especially under this administration.1
u/Banana_Phone888Ah don’t forget the weight gain that comes with limited activity, I know that one far too well. I’m sorry that you are going through this. With insurance I can’t afford to go to the doctor, it’s still 300-500.00 a visit without any kind of procedures, but u can’t imagine the cost without. I hope you feel better soon ❤️1
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53r/InterstellarKineticsBREAKING: Scientists Just Built Living Bodyguards for Insulin Cells That Could C...InterstellarKinetics4720%870.9stem cell therapy2026-03-03↗
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u/einstein2025And its not going to make it in market. They don’t want you to get well just get hooked on pills5
u/InterstellarKineticsThe immunosuppressive drug problem is the one that most people outside of transplant medicine do not fully appreciate. After an organ or cell transplant, the recipient's immune system has to be chemically suppressed for the rest of their life to prevent rejection. Those drugs work by broadly dampening immune activity, which means the patient is permanently more vulnerable to infections, cancers, and every other threat the immune system normally handles. For a 40 year old receiving a kidney transplant, the risk-benefit calculation is often clearly in favor of the transplant. For a child diagnosed with type 1 diabetes at age 8, a lifetime of immunosuppression starting in childhood is a genuinely difficult tradeoff. What the MUSC team built is a way to get tissue-specific immune tolerance without systemic immunosuppression. The engineered Tregs are not broadly suppressing the immune system. They are precisely positioned at the transplanted beta cells using the CAR receptor and their job is specifically to protect those cells from immune attack. The immune system continues to function normally everywhere else in the body. That specificity is the engineering achievement that changes the risk calculus entirely. The stem cell manufacturing side is equally important to understand at scale. Current islet transplants require beta cells from three to four organ donors per patient. There are not enough donors in the world to treat 1.5 million Americans with T1D, let alone the global population of approximately 8.4 million people with the disease. Lab grown beta cells that can be manufactured, quality-controlled, frozen, and shipped like any other pharmaceutical completely bypass that donor shortage. If the one-month durability in mouse models translates to multi-year durability in humans, this framework could be the actual end of daily insulin injections for the majority of people living with type 1 diabetes today. What other autoimmune conditions do you think this kind of targeted Treg bodyguard approach could be applied to next?4
u/Difficult-Till5031Hopefully this makes it out of trials. But I fear like a lot of other treatments it will be shelved or unaffordable.2
u/Broad-Term1872X: Doubt1
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54r/tropadocalvoSolução tópica que deve trazer a “cura” da calvice (PP405) tem resultados da fas...Federal_Isopod16231620%3170.8PRP knee treatment2026-03-29↗
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u/Acceptable-Charge163Caramba, baita notícia! Pesquisando aqui, já ta vendendo na Shoppe por 30 conto kkkkkkk. Brasil não é pra amadores msm14
u/Ok-Weather-5870Tire o responsável pela pesquisa clínica de dentro de aviões 🙏🏻9
u/CryptoBeatlesIsso aí é bem interessante. Combinando com finasterida e minoxidil, pode ter resultados muito bons em quem ainda não ficou completamente careca. Eu já me aceitei sem cabelos, acho que já até faz parte da minha identidade. Mas outro dia pedi pra IA fazer uma foto minha com cabelo, fiquei bonitão hahahaha7
u/tengolengolengoJá tô vendo que isso vai ser inacessível pra grande maioria. Infelizmente é assim, somos desesperados pra reverter isso e eles sabem disso.5
u/Federal_Isopod1623Informações adicionais para os interessados: PP405 é uma pequena molécula proprietária desenvolvida pela Pelage Pharmaceuticals; a estrutura química completa não foi divulgada publicamente, mas sabe-se que é formulada como um gel tópico. Por ser uma “small molecule”, tende a ser mais simples de fabricar e escalar do que terapias biológicas, o que no longo prazo pode ajudar a reduzir custos, embora no início ainda deva ser caro por conta da patente. O mecanismo de ação é o ponto mais diferente: em vez de atuar em hormônios, o PP405 parece reativar células-tronco do folículo capilar ao modular vias metabólicas (especialmente ligadas à mitocôndria), tirando o folículo de um estado dormente. Curiosamente, em estudos iniciais o tratamento foi usado por um período relativamente curto e ainda assim mostrou efeitos duradouros em parte dos pacientes, sugerindo que pode não depender de uso contínuo como os tratamentos atuais (isso ainda precisa ser confirmado em fase 3). Mesmo assim, provavelmente ainda será necessário combinar com bloqueadores de DHT como Finasteride ou Dutasteride, já que eles tratam a causa da miniaturização. Sem isso, o DHT pode continuar enfraquecendo os fios ao longo do tempo. Em comparação, o Minoxidil atua principalmente como estimulante (vasodilatação e prolongamento da fase anágena), sem regenerar o folículo. Outro ponto interessante é que o PP405 não mostrou absorção sistêmica relevante até agora, o que pode significar menos efeitos colaterais — mas isso ainda depende de estudos maiores.4
u/Dry_Measurement8864Indagação , há comentários que um dos princípios da ação é "intensificar reprodução celular " até em níveis "indiscriminados", ... Procede sobre terem especulado , justamente por isso , ter riscos de efeito a câncer ?3
u/Dangerous-Iron-6708Eu quero saber quais são os efeitos colaterais disso aí...2
u/ryansalleszEu penso que esse remédio não precisará ser usado por longos períodos. Eu penso que, é só usar por alguns meses para reativar o máximo de folículos possíveis, e então com um bloqueador de DHT, esses folículos sejam impedidos de miniaturizar novamente, possibilitando a suspensão do medicamento2
u/No_Position5003Acompanhando!! Kkk1
u/we-esQue coisa boa em. Tomara que os estudos avancem diretamente e de forma positiva ne1
u/Friendly_Sugar_986Amém1
u/Brilliant_Medium952032-2035 já tá pelo Brasil será?1
u/No_Cartographer_3997amigos, segurem esses folículos até o novo estado da arte1
u/oartistadoespetaculoDia péssimo para os Pau mole amantes da Finasterida-12
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55r/TrinidadandTobagoHilton leaving TrinidadMikeOxbig3051140%4670.5PRP knee treatment2026-03-22↗
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u/Hour-Incident6178The government has no place in these capital heavy type investments. The returns are not significant enough especially when royalties have to be paid to Hilton.36
u/PeakevoAssuming that a local company will step in and invest because the property is too valuable. It's also interesting to see Rhoda Bharath post and blame UNC for its closure.22
u/hislovingwifeThis is happening in other cities as well with big brand hotels.It's too expensive to update existing older structures and compete with newer, flashy properties, affordable (and sometimes luxury) airbnbs as well. The hotel business is hard to stay profitable for decades and decades. Sad to see this go, if it does. It should stay in some.capacity even if not Hilton branded.21
u/keilianaI stayed at the Hilton in Trinidad last year and it was really nice. I loved it. Very beautiful, the bar and restaurant were both amazing too. The pool area was great as well. I am sad they will be leaving because I hoped to visit again one day and stay there.18
u/arcanerebornWell this is sad to see, however seeing how poorly Magdalena is run in Tobago (massive under investment), its no surprise. Hotels should largely be a private venture, because they need constant maintenance, service standards, and an overall vision. This public-private venture allowed Trinidad to have a Hilton of this magnitude that was symbolic to the removal of a colonial power and the ushering in a new age for Trinidad. While its closure is what it is, a good representative of what the new direction of Trinidad will be. I'm sure the current administration is going to sell it and it becoming another closed garden away from the public, where old people will tell the young, "I remember what that view used to look like when you could stay there, dance there, discuss ideas there, eat there..." Nostalgia doesn't care, will see what happens next.17
u/mochapeau_nochapeauThis is so sad. The view from the restaurant overlooking the Savannah is incredible at sunset and a lot of people don't seem to know that. I love taking friends there for drinks and for many of them it's their first time going.11
u/964racerWe lived in the “hibiscus suite” for a month in the 70’s while we were looking for a permanent home. Good memories.8
u/whiteoak_and_doublesGood journalism8
u/v3int3yun0Well after reading the article in its entirety, I can't say I'm surprised. It's a shame though, I remember going there for a few dinners and overnight stays. Fantastic views of the QPS and downtown PoS.4
u/GroovyJediSign of the times3
u/iamcnicoleI stayed there for carnival and it was awful. I should have known when I got a shady non-Hilton link to prepay for my stay. They put all the YTs in the new tower and POCs in the old far away wing. Room was musty, fridge inoperable, and shower would flood from slow drainage. When I complained as a Gold member they told me to take a hike. Ended up escalating to corporate who ran me hella points. I understand why Hilton is pulling out and I hope it gets better management that actually cares.3
u/Icy-Benefit-5589Never stayed there, always stayed at the Brix next door when I visit Trinidad for business (mostly influenced by my Bonvoy membership). However, each time I stayed at the Brix I felt it's standards had dropped so I was hoping to try the Hilton on my next visit.2
u/StepFriendlyWith the loss of the Petro industry "business stay" clientele and the advent of Airbnb making some splendid homes available for rental this horse has possibly come to an end of it's reign! Hilton will attempt to milk the cow but the government must measure the value of the milk at this time. I would also ask the question when and if these global brands will restructure the policies to compete with the Airbnb's of today and allow the owners to profit and see value in these investments.1
u/asce619Simple to really understand this, taxation is theft. Ideally, taxes should not be spent on frivolous endeavors, they should be spent on civil infrastructure. That's what governments should be doing. Realistically though, 'I am prime minister, I can build a $40M+ estate and manor and that money is mine' is where we're at. Branding doesn't matter, Hilton can leave if they want, the building will be right there and probably be leased at $50 a month for 100 years through nepotism. Anyone gonna care?1
u/ShiizaaKerushiiWow I never thought I would see the day. This is extremely concerning.1
u/Effective-Ear-8367Maybe its just me but I can't even book anything with the hotel its 100% booked forever it seems. Are they just not taking anymore reservations?1
u/Johnny512436I love this hotel.1
u/SayKaasthat's unfortnate, maybe it will be plucked up by some private company maybe a place to put a data center?-1
u/OrdinaryAncient3573The real question here is why the government ever built or owned a hotel in the first place.-20
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56r/MultipleSclerosisNo more DMT after agressive evolutionRemyMajd1120%4670.5stem cell therapy2026-03-07↗
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u/youshouldseemeonpainThere was a new drug specifically for PPMS and SPMS that was supposed to get approved last December. The FDA denied it, but it may still come out later. It’s called Tolibrutinib, and I’m hoping they can jump through whatever hoops are required to get it on the market soon. I’m sorry for your situation. This disease sucks, specially PPMS.57
u/FragrantQuail5559I had a good friend with MS that was in a wheelchair by his mid 30s. I used to hang out with him and play monopoly and just talk. When I was diagnosed several years later I didn’t have the heart to tell him. He has a positive spirit. Stay positive. Life doesn’t end it just changes. Look into programs that can help you. If your doctors office has a social worker ask to speak with them to find out about assistance.52
u/jmoroni89Fuck. I'm right there with you brother. 37m. Been on Ocrevus for 4yrs, PT for 3. Nothing is helping. I've been told I should be in a wheelchair. I fall all of the time. My daily regimen, baclofen 30mg 4x a day, 10mg edible 2-4x a day. The edible helps my body relax more than just the baclofen. When I do too much (normal shit for regular people) my index and middle fingers on my right hand spasm and I can't bend them. They eventually go back to normal. We're too young for this shit man. I hope you find something that helps you and I hope you have someone to talk to about it all. Stay strong brother. FUCK MS41
u/LaurenlondonerHave you had a recent MRI? I’m sorry that is happening to you, MS sucks, and it’s scary😩😩19
u/ThermostatMcGeeHave you discussed Briumvi, Lemtrada, or Mavenclad?? I'm shocked she just wants to stop at Ocrevus. I've gone from Tysabri to Ocrevus to Briumvi. If needed, Mavenclad or Lemtrada are next up in my doctor's plan. Your rapid progression sounds like a reason for more intervention, not less.16
u/BucktoothWookieeAfter I “failed” a few meds, the last being Ocrevus, I did Lemtrada. Have you discussed that option? It’s “big guns” but finally stable and in a remission. And no ongoing infusions or anything anymore.13
u/SpookynashMS has destroyed too much of my body to even begin listing. Zero balance, legs declining significantly (below 30% function), spasticity, stiff back muscles (crazy painful). Mobility shot, nerve pain off the scale on a regular basis. It easier to tell you what doesn’t hurt, and what works properly. Crushing chest pain, not heart related. I’m only 53. Had to give up my job of computer programmer when I started 19 years old. NOBODY SHOULD HAVE TO LIVE LIKE THIS. You are not alone!! 🙏💛8
u/JooleyceeAHSCT available where you live? 38 is too young to stop treatment.6
u/BobbybezoYes, I'm in the same case, wheelchair and all, PPMS is quite something, I got diagnosed at 49 . Know that I'm with you!6
u/SpotTheDoggoI stopped ocrevus after 3-4 years recently, too. In my case, it was still effective, but I developed a very mild chronic lung infection. I cough up the nastiest shit. Sorry to hear about your struggles, buddy. :(6
u/Daurth_ZombieI’m most likely on my way. We should all paint our chairs SHINY AND CHROME!! WE SHALL RIDE ETERNAL THROUGH THE GATES OF VALHALLA!! My girlfriend is against this. BUT I WILL NOT BE DENIED!!!5
u/JustlookingfromSoCalI am more or less in the same situation. But I am a lot older than you. In addition to PT and Baclofen, I do find that Dalfampridine (Generic Ampyra) does help me with standing, balance and the steps I need to make when walker assisted transferring to and from bed or wheelchair and in and out of my bathroom which is too narrow for my chair. At your age, I wonder if trying a different DMT makes sense though. Are you able to get a second opinion from another Neuro with an MS specialty?4
u/Maleficent_Fun_7622talked with your neurologist about stem cell therapy?4
u/PK5002I have SPMS and was on Ocrevus for 2 1/2 years. My neurologist recently switched me to Tysabri because Ocrevus wasn't helping. MS just kept progressing while I was on Ocrevus.3
u/Jillo616I would personally look into another opinion. It’s quite possible meds will no longer help you, but damn. I wouldn’t want to give up. I’m sorry for your situation and I hope you find some relief.3
u/Tall-Pianist-935Get that new DMT And get some curcumin to help it along. Good Luck.3
u/Der_BingomannHello. I'm 44 years old. I was diagnosed with PPMS at the end of 2024. I can barely walk anymore. After just one year, I had a 60% disability rating and am already retired because I can no longer work. I need help with everything in my daily life. Ocrevus didn't work for me; on the contrary, I never felt worse, and all my symptoms worsened. I started making videos about it on YouTube. I'm taking baclofen and cannabis. I've stopped taking Ocrevus. There's nothing left to do but accept my fate...3
u/Ok-Elderberry7087Yes! Look for CAR-T. Life changing!2
u/dontgiveah00tI wish I had advice for the MS, mine doesn’t have me in a chair (yet) but it’s been 1.5 years and still struggle to walk a mile a day (spread out). However for mental heath Spravato really helped me and low dose naltrexone for pain and mood.2
u/buderfwyDon't give up! You're important and meant to be here. I love you and am glad we share the same earth at the same time. Keep fighting2
u/Far_Ebb_7477Yup. Full time wheelchair user now. Diagnosis PPMS, not taking any ms drugs anymore. Just baclofen and fampyra. Fampyra has helped give me slightly more strength. I think it's called ampyra in the states. I'm in Canada. The meds make the signals jump down the nerves (instead of going down a straight line) with the hopes of skipping a lesion. I mean I can't walk, but when I don't take the meds I have a harder time transferring to the toilet or holding utensils. With the meds it's easier. It's expensive though I was a photographer and an artist. And now , I don't know what I am2
u/Wooden-Use-2640I have primary progressive multiple sclerosis and my neurologist tried telling me the same thing.2
u/Electronic-Mammoth19Sending prayers man. 38m here too although early in my journey as I was diagnosed last year. Just did my first infusion of BRIUMVI earlier this week and been on a strict diet since the last relapse. It’s honestly been happening for years, so I’m happy to have an explanation. I read these forums but rarely comment, but your story touched me and I wanted to say you are in my thoughts and prayers.2
u/Ill_Algae_5369I'm so sorry. I don't know where you are but maybe there are trials you can get in on? Even if for movement and spacicity not the lesion activity itself?1
u/Murky_Bird_2695I’ve been dealing with this since seventeen unfortunately but I’m now bedridden and wheelchair bound. 31 now. Definitely sucks1
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57r/hollisUncensoredRecap below of a little gem I found last week. Heidi's TEA IS PIPING today! TW f...greeneyedgarden610%25170.4PRP knee treatment2026-03-23↗
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u/ChewieBearStareI didn't even get past "Helped Dave Hollis with addiction." How did she help him? By outing that he was in rehab? By being a chaos gremlin when he was struggling? WTF?! Anyway, back to the recap. We really should start a GFM to help you buy some self-care items after listening to this BS.110
u/greeneyedgarden"I hope those I've hurt are grateful I've hurt them." Heidi is a horrible person and please have mercy on those kids of hers.100
u/holavivi23"I LOVE LOVE LOVE the pain and lessons I've given to people." That's some sick shit to say. She's basically doing Olympic level mental gymnastics to absolve herself of every bit of legitimate blame and shame for her actions that hurt others. I think she also does those mental gymnastics to absolve her parents' extreme dysfunction and the myriad ways it hurt her and fucked up her life. Why is she allergic to acknowledging reality and taking accountability? And why can't she hold others accountable where appropriate?83
u/Remote-Ad1462Good god, she has no right to be talking about his problems publicly like this. I would be so uncomfortable!82
u/PleasantRabbit1511Goodness. Kratom, alcohol, vaping… She portrays such a different image online. This is wild.71
u/heyysunshinethe last part of the transcription is......so jarring. i don't want to completely dismiss it because everyone deals and copes with their SA trauma in different ways. but saying we're meant to deal with the pain life inflicted on us is a rough statement. it's why i hate self-helf bullshit. there are systems and people in power who shape our reality & what we experience, it takes accountability away from these systems and their destruction. like sorry, i dont think i was put on this earth to experience chronic illness beginning at age 19, job insecurity due to said illnesses, be abused, or feel scared existing in this country lol. maybe thinking you had to go through it helps people who struggle with the trauma from lack of agency, but i think it's very validating to point out where you've been failed or wronged. heidi, you didn't need to experience an ED, SA, addiction, and death of loved ones to become the person you needed to be. you deserved better than that. and i hate that message being spread to vulnerable or young people dealing with trauma67
u/She_said_what13And just like that, I’m absolutely livid all over again. For context, I’m the EMDR therapist who has done some breakdowns here of Heidi’s content through a borderline personality lens. I specialize in complex trauma, eating disorders, and domestic violence. I also have lived experience. I was in inpatient treatment for my own eating disorder in 2006 and spent years in EMDR therapy before eventually becoming a therapist myself, which didn’t happen until more than a decade after my recovery. I was also in the inner circle of Heidi and Dave’s very first challenge. I joined because I wanted to get strong and be part of a like-minded community. What pulled me in was her story about eating disorder recovery. I genuinely believed this would be a fitness space that stayed far away from toxic diet culture and aligned with my values around body image and health. I didn’t know much about her at the time, and I knew nothing about Dave. I went all in. There were some truly wonderful people in that group. That part was real. But it started going sideways for me pretty quickly. I began noticing things that didn’t line up. The values being talked about did not match what was actually happening. There was a growing sense of incongruence that I couldn’t ignore. I will tell the full story here at some point, because there is a lot more there. But this is what I need to say right now. Every time more information comes out about what was actually happening behind the scenes, how they were actually living, the level of addiction and chaos, I feel a fresh wave of rage. I WANT EVERY DOLLAR BACK THAT I GAVE THEM. They charged people thousands of dollars to be led by individuals who were actively in the depths of addiction. They positioned themselves as guides for health, growth, and community while their own lives were completely unregulated behind the scenes. That is not just hypocrisy. That is exploitation. She knew, and she continued to sell, upsell, and expand those offerings anyway. That is the part I cannot let go of. I joined the second challenge because of the relationships I had built with other members. But when Dave went to rehab and then showed up on a live from rehab, that was my breaking point. And now, hearing more details about what was actually happening during that time, the level of substance use and instability, it is absolutely infuriating all over again. This was not just messy. It was irresponsible, unethical, and harmful. I am feeling re-inspired to write out the full account of what I experienced and witnessed, because people deserve to understand what they were actually participating in. And everyone out there deserves to know exactly who she is so she cannot continue to exploit and harm more people. Thanks for letting me get this out.66
u/TheAlligator0228Get his name out of your mouth, and stop using his death for your content. Cease and desist!!!!65
u/holavivi23Dave was a heavy smoker and then a vaper?! That's something I didn't know. I wonder how long he smoked? Doesn't pair very well with running. I'd be very interested to know Rachel's tea about Double Life Dave.56
u/paddycat19I'm guessing Heidi is talking about Great Scott being addicted to Feel Free? Someone commented here a few months ago that their friend had DMd Heidi, and Heidi wrote back and word vomited TMI about all kinds of stuff in her life. One of the things she said was that Great Scott went into rehab multiple times when they were dating. Sounds like that's confirmed here.48
u/redditmamaphoFucking bitch knew he was drunk depressed and had a gun and was looking for it and didn’t call the police? Cunt47
u/villabellissimou/hairyresolution4011 Can you please do a livestream on this episode?47
u/greeneyedgardenThe host propositioned Ryan!!!42
u/ninfaobsidianaI wish I knew what people like her hear when they hear people say things like: “It looks to me like you’re on something” when they are, in fact, on something. I abused alcohol for years. No one save a very few people in my life knew because I was high functioning, and I kept my activities pretty low key and late night — no day drinking, no drinking on the job, and I could hold my own when out and about, so no public sloppiness. In fact, Sandra Lee would not bat an eye at my drinking. But it was bad because it was how I was dealing with my mental health and trauma, rather than seeing a therapist and really learning to heal. A loved one — one of the very few who knew me well enough to see that something was wrong — called me in. Wanted me to feel better and get help. I knew they were not wrong, or being hateful, or bullying me. I knew they were telling me an objective truth. Didn’t mean I rushed to take care of myself right away, but it was still an important moment that helped me get into recovery when the time came. So when people dismiss criticism with “you just hate me,” and then casually reveal that, in fact, they had been in the throes of addictions the whole time without ever acknowledging that all of those bystanders were correct, I wonder what is happening in their brains. I know it’s a level of shame, but what about the egoism that stops them saying “Yes, I have a problem”? Dave was the same way, only I think he was self-acknowledging, and that was incredibly difficult for him. I also believe less and less of her “truth,” and I never believed very much of it to begin with. Every few interviews she reveals a new nugget of information that discredits almost everything she’s ever said before it. It wouldn’t be a big deal if she stopped trying to monetize her self-help grifts and brand — people are sometimes shitty in their personal lives. That’s just life. It’s appalling that it even halfway works.42
u/Klutzy_Spell4852If only her fan poodles could read/listen to these. They all think she is the epitome of health and happiness. I wonder what Temu's addiction is because her "picker" is drawn to them! But also, didn't Tanya claim that super Dave never sold drugs? I wonder if she had the chance to listen to this one.41
u/ResolutionOk5211LAURI LANE... where's your desperate ass friend to defend you while you DENIED your daughter treatment for anorexia and bulimia??!!41
u/EvillittleangelAm I crazy for remembering that she was very clear about them NOT BEING TOGETHER?? Then he dies and all of the sudden she became the widowed girlfriend? His children must hate her so much.40
u/DarthSnarkerSomething that's always bothered me (and I'm not sure if this was discussed before), but if she knew he was an alcoholic and vaping (plus whatever substances), why did she push him so hard to do the body building stuff?40
u/lovethatssleepingSooo many thoughts. Dave bringing vodka on their first trip. Well if she had read his first book like she claimed, she would know he had an alcohol problem. Cigarettes and vaping?! Dave relapsed and she didn’t know?! We could all tell he was not ok! Dave believed what the haters said about him? Well shit, some of it was not nice, but we weren’t wrong, so…… She thought he was going to hurt himself but just said good night and then she just carries on? Second, her dad was selling prescription drugs?!Just wow. I feel like I’ve read here that Heidi accused Derek of doing pills (and maybe Chris was on pills before too?). Also I don’t know what the hell Feel Free is but what the fuck. So this is the second time she’s mentioned Scott going to treatment. Every man she’s involved with has an addiction, as does she. She needs therapy. This is not okay.38
u/MirkatteWorld[Dave] was the best person and he got a lot of online hate. He believed what people said about him. Heidi, not everything people said about him was wrong, nor was it all hate. There is a difference between constructive criticism and hate. Maybe, just maybe, Dave's "believing" was actually self-awareness.37
u/Salt-Freedom-7631She let Dave go, but yet still talks about him all the time. And I'm pretty sure a lot of what is said in this episode contradicts a lot of things she's said before. Like. ALOT Also. Dave did a damn good job of hiding he was a cigarette smoker. Thing this is the first time I've heard of that. And I read 2 of Rachel's books36
u/Traditional_Paint461I listened to this episode and she really did overshare allllll these details. Craziness.36
u/FAladyI wonder if Great Scott got her into Kratom? And what idiot doesn’t know it is addictive? This pisses me off. Heidi and Dave were hosting their challenges and acting like the perfect wholesome paragons of health while abusing substances. This also confirms what we all knew - that HIGHdi is an addict. Trashing religion isn’t gonna look good to her Mormon audience. She really needs to stop talking about this stuff online and get help, but that is not gonna happen.36
u/villabellissimoI have always assumed that RyGuy is either an addict or is experimenting with drugs with Heidi, or he at least enables her. Everyone she dates seems to be an addict.35
u/WILLIAMEANAJENKINS“I didn’t know kratom was addictive “…I was mixing it with other things and was living a lifestyle .. I had money and power and I could party …”… Everything about her delusional narcissistic problems is explained right there.34
u/MembershipOver344Heidi : “Religion f$!*s us up” -your son is on a mission trip currently…31
u/emaydee30
u/Charming_Smile_5398But she said she never drank when she was with Dave. Nothing like integrity and authenticity.29
u/[deleted]Unfortunately I'm not shocked about any of this because it's Heidi and she's terrible.29
u/greeneyedgardenAll of this, and she still let Dave live in the house with her kids28
u/youhadtotakethesoupThank you for transcribing all this 😵‍💫27
u/sunnydays97Maybe Heidi can clarify- Regarding post high school, post ASU, running to UTAH and getting D’s and F’s….. She states “I was able to make it through school and get good grades” Didn’t this chick drop out of post secondary education? She makes zero sense.27
u/annabelleoftheballDamn, she is one sick puppy.24
u/Genybear12So we have…. Lying about how Dave died? Implying it was only related to drinking. Cultural appropriation… yes I’m calling it that cause doubt her Mormon White self knows how to obtain sage correctly, how to prepare it properly and then use it plus dispose of it. Religion fucks us up…. But she’s a closeted Mormon who pretends to be either something else for her men or nothing at all if they don’t have one or are running away from it like Temu BUT ALSO let’s raise our children in the same religion that “fucks us up”. Ignoring what addiction is…. It’s ok Heidi to admit you have an addictive personality and will become addicted to anything you think “helps you” or makes you money. Addiction is a disease and it’s ok to accept that, understand it runs in families and more. There is help. Is she saying she accepts fault in being sexually and physically abused?!?! Like she asked for it to have it help her become better? I mean….. NO ONE ever has done anything a day in their life to ask for someone to sexually, physically, emotionally or mentally abuse them. To say you thank those that did it to you and imply you’ve forgiven them openly and directly because you asked for it? Forgiveness is personal plus meant for the person the actions were done to to give to themselves, possibly given to the person who committed the act at a time later and possibly unknown to that person in order for the victim to accept what’s happened to them to accept and be able to move on. Ok ok I need a break that last one may have spiked my blood pressure a little too much.24
u/Comfortable_Bag9303The girl doesn't need a podcast; she needs inpatient care. Her neck of the woods has so many good facilities. How do I know? My family member is in one right now. (yes, the one I've been agonizing/praying about for years!) There is REAL help out there: medication, talk therapy, EMDR, etc. He is finally thriving after YEARS of suffering from drug abuse, trauma, and denial. And if I happen to bump into Heidi while wandering the streets of Gilbert/Chandler, I'll be sure to not say hi. But dang I would want to drag her to The Meadows....23
u/heyysunshinealso, being new to hollisville, i'm still learning about them as people. but part of me wonders if heidi's oversharing and intimate details about dave's death are all misplaced grief. like im wondering what kind of support she's getting around dave's death? i lost an ex back when i was just a teenager & when it finally hit me i was in shambles. it's such a unique type of grief in that you weren't with them, youre not a widow. but there's a closeness that was there that others (the widowed) may not want to hear in Their grief. but i wanted to talk about him as much as i could, it felt like keeping him alive in a way. everything that connected you feels monumentally important. this seems to be addiction for them. and i wonder if there's a sort of sad "see, i WAS important to him!!!!" thing going on in her talking about how involved she was in the night of his passing. idk, i feel like she needs more spaces offline to air these things. ik she exploits every aspect of her life & those around her for content, but. blugh. i can kind of understand the drive, as sad and messed up and exploitative as it is (i do NOT condone it!!!) but also, on the flip side, it's interesting to see rachel's complete silence. there's no middle ground with them.21
u/EyeLittle415This is so gross. So so gross. His story is not hers to tell. And she is full of lies.20
u/YoKinaZuWhen will she stop celebrating her horrible parents??19
u/shruglife1985Did you find it worth listening?17
u/caffeinatedangelI have only just read the description and found myself already screaming: "Dave wasn't her boyfriend, he wasn't her partner!"16
u/Agitated-SparepartsThe way she tells a story she is all over the place so you can't really assemble a timeline...but it sounds like she probably started this Feel Free with Dave or right after Dave...she probably got GS hooked on this stuff and then was like "you need to go to rehab". I am not one to shame or blame anyone...but HIGH-Dee seems like the common denominator when it comes to all the chaos that has been created and inflicted in anyone's life who has touched hers. She is a hurricane alright. You enter her path and it is guaranteed for destruction. The more I read this over again I think, what a sick and demented woman. "I LOVE LOVE LOVE the pain and lessons I’ve given to people" and "I hope those who I have hurt look at me and are so glad I did what I did to them." What the actual F??? Who says these things unless you are completely unhinged.16
u/Comfortable_Bag9303This has shades of Ruby Franke & Jodi ...13
u/Status-Visual6022So based on her logic kids/babies with cancer are meant to have it. Fuck off.9
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58r/lipedemaUpdate #2HumanistGoddess980%5270.3PRP knee treatment2026-03-19↗
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u/Longjumping_Baby_955I think you look great and the improvements are super noticeable, but more importantly, why is your husband being such a jerk?? You’re worthy at any size or shape and it’s so commendable that you’re trying to better yourself, he should be supporting that95
u/HumanistGoddess<image> My last update.50
u/C0l3yI’ll say what your husband should but won’t. First, I am so proud of you for committing to yourself and your routine! The amount of improvement in texture is honestly blind blowing to me, and I promise I’m not just gassing you up. Your legs look amazing and are a reflection of your commitment so keep it up. Thanks for sharing - I think your photos will give us (me included) a lot of hope. Can I ask what GLP-1 you’re on and at what dose? Have you had any side effects?41
u/mrose8383There is a a huge improvement … but wtf to your husband.19
u/pep0werYou look fantastic. I hope you are proud of everything you accomplished. However you want to say it, lipedema is a condition of your connective tissue. It is extremely unlikely that the texture of your legs will ever be “normal” for whatever that means. Your husband is gaslighting you, he can go eat a dick and fuck off.17
u/FreshPath6271Great results and most importantly great job caring for your health and working on it to make you feel better. I will say what others said your husband needs to refrain from comments like that. Lipedema is a medical condition. More understanding and compassion and less judgement for him needs to be learned. Maybe talking to him about it and teaching can make him have more understanding. Keep up the amazing dedication and work on your health!13
u/jmack619You look great! Your legs look so different from your first two photos. This is really inspiring. Way to go!12
u/HumanistGoddess<image> 1st post10
u/HumanistGoddessThanks for the positive feedback guys. I really appreciate all of the positive energy. I am so happy with my results. I can’t wait to post an update in another couple months!! I just asked my husband about his comments and he said “I would never say that” and blamed it on a dream I must have had. It wasn’t a dream. The best revenge is looking good and maybe finding support from others.9
u/Eastern-Activity6700Girl the cringe I just made reading your husband commenting on your body negatively….not ok. You gotta teach him how to communicate effectively…. Your legs look fuxking awesome, it’s not about being perfect it’s about being better and feeling better. Will lippy legs ever look like non lippy legs? Probably not without surgery, but our partners can empower us to soothe that urge to go under the knife (if that’s your preferred choice). My wife only ever tells me how great my legs look and comments on how proud she is for my consistency in conservative treatments. Maybe remind him to focus on compliments and staying positive instead of helping you ruminate about something you’ve already identified you don’t like about yourself.7
u/Alchia79Wow! These are amazing results. I started Mounjaro six weeks ago and haven’t noticed any difference. I also just finished eight weeks of vein ablation and sclerotherapy so hoping to see some improvement once that’s healed up. I am super impressed and inspired. I’ve been afraid to do any kind of HRT. I’m about to turn 47 and my lipedema has really taken off thanks to perimenopause. My legs and arms are just like your before picture. Can you give me a general idea of what you are doing for exercise? I need to start weights, but also have hEDS and some joint pain so squats and anything knee related is hard for me. Thanks! And congrats 🎉4
u/TemporaryAshamed9525Thank you so much for this. We are lipidema twins - I have the exact same legs! I've been on the fence about the GLP but I think this is the sign that I should start!3
u/m33p047Your husband can get bent. 🤣 You look amazing, and as someone with stage 3, I hope to get to where you are one day.2
u/weebeaniesId KILL for your gorgeous legs x2
u/Brilliant-Ad232What an inspiration2
u/Dazzling-End-9575You look amazing and i would be thrilled to have legs that look like yours! Congrats. Do you mind sharing about your GLP experience with side effects? I go to the gym 2-4 times a week for strength training and do lots of walking every day but i feel like it doesnt do as much as i would hope.2
u/SPSKINOmg wow… these are amazing results! You are giving me hope!2
u/Salty_Coast_7214How did you get a glp-1? I, like you, am not overweight my doc won’t give me any2
u/Taylan_KYour legs look amazing, I thought they don't look like lipedema at all until I saw your last update photo. Amazing improvement I must say, I am really impressed. What is the purpose of the testosterone pill? Never heard of that.2
u/Addiegirl79You look AMAZING. 2. F that dumb boy. 3. I would kill for those honeybuns. ❤️1
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59r/PsoriasisMy dog helped my psoriasisthe_madcapper980%5070.2PRP knee treatment2026-03-15↗
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u/murderd0llI appreciate the fact that we will literally try anything to help because everything about psoriasis is just so hit and miss.170
u/Own-Event4824The best anecdotal evidence I’ve ever seen in my life.42
u/Cheesy_crumpetMy Niece’s dog used to lick the patch on my calf, he could sense it through my jeans and knew exactly where it was. He would only lick that spot through my jeans and nowhere else. Currently living with a bulldog who is a constant licker. In general though, he just likes the salt from sweat. Sometimes he licks the patch, which is now quite big. Might start letting him ‘have a go’ more often and see if it begins to go away.39
u/This_Is_Great_2020my dog does the same thing on my elbows, and yes it helps alot.26
u/NoParticular2420Open skin and mouth germs could = bad20
u/JarJarBinksSucksI’ve often wondered about this. (I don’t have dogs) Dogs I meet in public always seem to go for my psoriasis knee. As do dogs I know. I’ve wondered if there was any medical benefit or worthy of trials15
u/peaceomind88This same exact thing has happened to me!11
u/Leahs_life_I follow a girl on instagram who has atopic dermatitis and one of her service dog’s tasks is to interrupt scratching!9
u/baicoi66Ive heard it only works if the dog licks his ass before it licks you6
u/queenmebWe used to call my uncle crazy for saying his dog licking him cured him!! I’m glad to see he’s not and someone else has actually experienced this. Now how do I get a dog to lick my scalp…5
u/EatsCrackersMaybe the germs in the spit give the immune system something pathogenic to attack, rather than continuing to attack the skin? I’m not gonna try to yuck your yum (or itch your “ahh!” as the case may be), but keep an eye out for swelling, redness, pus, or any other signs of infection, and seek medical attention promptly if any crop up. Ain’t nobody got time for sepsis!5
u/DoubleDonkI once heard from a teacher about a student with psoriasis he had taught before me who had a pet snail she would let crawl across her skin that soothed her psoriasis. Stuff is wild man.4
u/Florin500The amount of pseudo-science and straight up dangerous misinformation comments are way too high, people shouldn't spread this kind of bullshit4
u/romanescadanteThis might sound weird but in my hippy faze, I read that forgiveness heals and that information hit me like a brick, so I thought about all the people I would forgive. 2 days later, my scalp psoriasis was gone. I thought I was going a bit insane. It eventually came back, but wild experience for me.4
u/PowerfulNecessary180have you tried your own saliva?3
u/TawGreythis is because there is a mechanism designed into the saliva of animals.. as they lick their wounds also.3
u/grandmastatus0I always wondered about that when I was younger (I got pso at 14) but no matter how much I let my dog lick my knees it never helped haha.3
u/SpiderVinesLong story short, dog saliva has minor coagulants and wound healing properties as well as some antibacterial properties against some strains of bacteria, but not streptococcus or Capnocytophaga. So if you’re on a biologic please dont let your dogs lick your open wounds! You’re better off using a healing ointment and some non petroleum jelly. 🫶2
u/twelveangrykenI've had dogs the entirety of my "psoriasis journey", which was more like a slow 23 year ride to hell, and they all ignored it until this last one. He started licking my ankles in my sleep or when I was sitting on the sofa. I'd shoo him away, but he was relentless - and making it so much worse. He actually drove me to try a biologic, and now I'm nearly 100% clear, so I guess I could also say that my dog's licking fixed my psoriasis.1
u/Interesting_Pea2108Nope.1
u/IndustrialPuppetTwoI wonder if it's a symbiotic relationship LOL! I mean what does the dog get from it?1
u/L-RockatanskyThis sounds like a great way to get a severe skin infection1
u/phat_gooberoniMy dogs licking my psoriasis largely has just made it worse I suppose due to the exfoliation lol I have to practically fight them off of trying to lick it now1
u/hooola-hooopOne of my cats licks my psoriasis patch on one of my legs. I don’t think it helps though 😂1
u/RedditRecreationsBrb going to run naked in the dog park1
u/Delicious-Aspect-637Dogs saliva can give you meningitis. Not a good idea to let them lick you anywhere.1
u/Fast_Compote_3233My parents dog also always used to specifically only lick my psoriasis spots. I honestly think they can either smell or sense that it's a medical issue and they're drawn to it for some reason.1
u/VegemiteGeckoI haven't let them keep licking my knee patch, but my two definitely like something about it and try to lick it a lot.1
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u/No_Entertainer_299It is because you relaxed when your dog licked you, relaxation is the only cure for psoriasis, unfortunately, no one can relax all the time
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60r/immortalistsMitochondrial Dysfunction is a major hallmark of aging. By repairing Mitochondri...GarifalliaPapa1940%2070.1stem cell therapy2026-03-23↗
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u/GarifalliaPapaI am writing this for the other scientists who are interested in the aging science (advanced mechanisms): Mitochondria function is a central regulator of aging because they integrate energy production, redox balance, apoptosis, and immune signaling into a single system. Their primary role in ATP generation through oxidative phosphorylation links directly to cellular repair capacity, while their production of reactive oxygen species (ROS) acts both as a signaling mechanism and a source of damage. In parallel, mitochondria control programmed cell death via cytochrome c release and contribute to innate immunity when mitochondrial DNA (mtDNA) leaks into the cytosol and activates danger pathways. When mitochondrial quality declines, these systems become dysregulated simultaneously, making mitochondrial dysfunction both a driver and amplifier of aging. With age, mitochondria accumulate a set of characteristic defects that impair their function. Mutations in mtDNA disrupt electron transport chain (ETC) proteins, reducing efficiency and increasing electron leakage. This leads to elevated ROS production, which damages lipids, proteins, and nucleic acids. At the same time, mitochondrial dynamics become imbalanced: fusion processes (regulated by MFN1/2 and OPA1) decline, while excessive fission (linked to DRP1 activity) fragments the network. Compounding this, mitophagy (the process that removes damaged mitochondria) becomes inefficient, allowing dysfunctional organelles to accumulate and dominate the cellular environment. These defects form a self-reinforcing feedback loop that accelerates aging. Initial mitochondrial damage reduces ETC efficiency, increasing ROS generation. ROS then damages mtDNA and mitochondrial membranes further, worsening dysfunction. Impaired mitophagy prevents the removal of these damaged units, while the release of mtDNA into the cytoplasm activates innate immune pathways such as cGAS–STING, driving chronic inflammation. This inflammatory state feeds back into mitochondrial damage, linking mitochondrial decline tightly with systemic inflammaging and cellular senescence. As mitochondrial performance deteriorates, cells experience a bioenergetic crisis. ATP production drops, impairing essential processes such as ion transport, protein synthesis, and DNA repair. The increased AMP/ATP ratio chronically activates AMPK as a compensatory mechanism, but this cannot fully restore energy balance. Cells increasingly rely on glycolysis, a less efficient pathway, creating a pseudo-Warburg metabolic state even outside cancer. At the organism level, this manifests as sarcopenia, reduced brain energy metabolism contributing to neurodegeneration, and diminished functional reserve across organs. Mitochondria also exert direct control over nuclear genome stability and epigenetic regulation. Excess ROS induces nuclear DNA damage, while declining NAD⁺ levels impair the activity of key repair enzymes such as PARP1 and sirtuins (SIRT1, SIRT6). Additionally, mitochondrial metabolites act as cofactors for epigenetic enzymes: acetyl-CoA drives histone acetylation, α-ketoglutarate regulates DNA demethylation, and NAD⁺ supports deacetylation. When mitochondrial metabolism is disrupted, these epigenetic processes become unstable, leading to epigenetic drift, altered gene expression, and reduced cellular resilience. To maintain mitochondrial integrity, cells rely on a coordinated quality control system. Mitochondrial biogenesis, driven by PGC-1α, AMPK, and SIRT1, generates new organelles. Mitophagy, regulated by the PINK1/Parkin pathway, selectively removes damaged mitochondria. Meanwhile, dynamic fusion and fission processes allow mitochondria to exchange contents and isolate defective components. Aging disrupts all three arms: biogenesis declines, mitophagy becomes inefficient, and dynamics lose balance, resulting in a network increasingly composed of dysfunctional mitochondria. Lifestyle interventions remain the most robust methods for improving mitochondrial function in humans because they directly target these quality control pathways. Exercise activates AMPK and PGC-1α, stimulating mitochondrial biogenesis and improving respiratory efficiency. Fasting and caloric restriction increase NAD⁺ levels, activating sirtuins and enhancing both autophagy and mitophagy while reducing ROS production. Hormetic stressors such as heat and cold exposure induce protective pathways, including heat shock proteins and FOXO3, which enhance mitochondrial resilience. Sleep and circadian alignment further regulate mitochondrial gene expression and oxidative stress cycles, maintaining temporal coordination of repair processes. Nutritional and pharmacological compounds can support mitochondrial function, although their effects are generally modulatory. NAD⁺ precursors such as NMN and NR restore intracellular NAD⁺ pools, enhancing sirtuin activity and DNA repair. CoQ10 supports electron transport within the ETC, while alpha-lipoic aci9
u/GarifalliaPapaBest scientific research: [1] Mitochondrial Dysfunction as a Central Hallmark and Driver of Aging https://www.tandfonline.com/doi/full/10.1080/28347056.2025.2560191 [2] Mitochondria as a Target for Rejuvenation and Anti-Aging Therapies https://pmc.ncbi.nlm.nih.gov/articles/PMC10917551/ [3] Role of Mitochondria in Oxidative Stress, Inflammation, and Aging https://www.nature.com/articles/s41392-025-02253-4 [4] Novel Mitochondrial Mechanisms Underlying Anti-Aging and Longevity https://www.news-medical.net/news/20251210/Study-elucidates-novel-mitochondrial-mechanisms-underlying-anti-aging-and-longevity.aspx [5] Urolithin A Supplementation Improves Muscle Endurance and Mitochondrial Function https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 [6] Clinical Evidence on Urolithin A and Mitochondrial Health in Humans https://pubmed.ncbi.nlm.nih.gov/35050355/ [7] Mechanisms of Red Light Therapy and Its Effects on Mitochondrial Function https://optimalhealth.co/resources/red-light-therapy/science [8] Photon–Cell Interaction Mechanisms in Low-Level Light Therapy and Mitochondria https://www.liebertpub.com/doi/10.1089/photob.2018.4606 [9] Mitochondrial Donation Therapy: Clinical Advances and Birth Outcomes https://www.ncl.ac.uk/press/articles/latest/2025/07/mitochondrialdonationtreatment/6
u/EnclicidusGreat read. Our mitochondria are such a vital factor in so many facets of life. Looking more into and loving it. I’d like to add that last year I was trying to get a low body fat % and was doing intermittent fasting (18 hours) + the keto diet. While people did mention I looked lean and kinda sickly (lol), I had never felt so great in my 32 years of life. It was a hassle restricting carbs to under 30g while also caloric restricting myself, but the mental clarity, energy, and feeling so energized/healthy was unlike anything else for me. It was a sort of high I’d like to recreate but I’m unsure of if it was one or the combo. Will be trying it again this year.5
u/Pale-Stranger-9743Would methylene blue be a good tool to help with this?3
u/princesspoolExcellent work, new stuff here for me to dig into- thank you2
u/mdeeebeee-101Do nitric oxide powders used for gym pump vascularity hinder mitochondria ?2
u/YonKro22Is that why standing in front of a fire feels so good and is good for you I think it's got to be way better than standing in front of an artificial infrared light for one thing we grew up as a species doing just that2
u/Ill_Mousse_4240Another fascinating read! Really hope such research garners more attention. Powerful individuals like Musk and Bezos are trying to outdo each other in outer space. Individuals who, like us, exist in today’s world of limited lifespans. Each year that goes by affects them as irrevocably as everyone else. Unlike everyone else, they have the resources for effecting meaningful change. Yet, perhaps not realizing this, they continue focusing elsewhere. Like mayflies obsessed with sequoias2
u/Rude-Dealer9188Parasite Eve taught me this... but thank you 😊2
u/smart-monkey-orgFor now I'm sticking with exercise, fasting and GlyNac.1
u/Tasty-Windowwas just thinking about this1
u/ProprietorSooo…. Do some Wim Hoff and charge the mitochondria?1
u/kojefI don’t hear much about hydergine these days when reading about improving mitochondrial function. Why is that?1
u/Syn-thIs there a tldr?1
u/[deleted]Redact cleaned up all of my comments. Bulk deletion and editing is a feature supported to make sure that AI scrapers can't access my data for training. cobweb fade smart spoon hat work deliver juggle boast longing
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61r/Livimmune2026 AACR Glioblastoma Multiforme Poster & AbstractMGK_2930%4969.9induced pluripotent stem cells2026-03-23↗
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u/Tra-Kal34Would love to know what the conversations are with Big Pharma at the moment? ?negative33
u/Chemical_Sky6013Thank you u/MGK_2 once again for an excellent post. I've written in the past about my long journey with CYDY, and many of you have shared similar experiences. It's been really hard to stay invested for all these years and not lose hope. What I didn't share earlier, was that around the time that this thing hit 14 cents in November 2024, I saw a post on FB that said, "Sometimes when you're in a dark place, you think you've been buried, but you've actually been planted." And that's when I told myself it was time to start buying again. And now those seeds are about to bloom for all of us! This company is almost entirely owned by individuals... who kept the faith when everyone "in the know" fled. And soon we will have a beautiful garden to enjoy. Congratulations to all the longs!positive33
u/CytosphereThis is an excellent explanation of complex phenomena.positive28
u/Tra-Kal34Praise the Lord, we are getting closer and closer.positive27
u/paistecymbalsrockThe data has arrived!positive24
u/upCYDYWahoooooo ‼️ thank you MGK for this thorough explanation‼️🧨🙌🙌🙌 THIS🤗👍‼️FANTASTIC NEWS 💃positive23
u/surfgolf4lifeGreat post MGK. Patiently waiting for PRs and more good news👏👏👏positive23
u/Jtzdad5673A couple of years ago my niece told me about a friend, a close friend; who was intelligent and kind. He had everything it took to lead a very successful life, until he was diagnosed with GBM. He faced his illness with great courage and grit. He truly lived “one day at a time” knowing he didn’t have much time left. When my niece told me about his illness, I immediately told her about CytoDyn and leronlimab. I continued to stress the importance of having his physicians use the “Right To Try” statute and get him on leronlimab. Of course his physicians never heard of CytoDyn or leronlimab, nothing came of it, and once again the GBM won. I think he lived about 18 months after his diagnosis. He wasn’t even 30 years old when he died. The same thing happened when my cousin with a wife and four children had a massive stroke a few years ago. (I’ve posted about this here before). I called CytoDyn myself to request leronlimab for my cousin and Dr Scott Kelly was more than willing to send it to his physicians in Houston, but they (his doctors) refused to contact CytoDyn. He died six months later, on his 50th birthday. Had their doctors followed through, both the young man and my cousin might be alive today. Go CYDY!negative22
u/Pharma_JunkeeExcellent breakdown MGKpositive21
u/Missy2021Just a matter of time now, that Leronlimab blows the doors off of Big Pharma! Thanks again.positive20
u/Pharma_Junkee🙏🙏🙏positive19
u/UpwithstockBOOOOOM! Thank you for the plain language breakdown my brother! Your post was by far the best read I have had regarding the science! Loved: The abstract is a declaration of Kinetic Validation! The physics of the TME has been solved!! Now let the interested BP’s come to PAPA Dr. J and Uncle Hoffman! The Golden Tsunami is coming!!positive18
u/Pristine_Hunter_9506Thanks brother another step forward.positive17
u/megadunamisThank you for your analysis of the results. GBM is a tough cancer to crack, call Leronlimab to the rescue...positive15
u/twinter11That was nice write up! And it look like pestell and team were hard at it and I'm sure more to learn. I can't think of anything to ask Thanks Mgk!positive15
u/Doctor-MTJMGK, This IMHO is one of your very best posts. Great explanations of very complex processes in a very concise, easy to understand manor...Thank you my friend for all that you do! Things are really coelescing at a very fast rate right now. It feels like this is all leading to a big Crescendo very soon!positive15
u/waxonwaxoff2920Many thanks for the work you do here MGK. YOU ARE APPRECIATED BROTHER. 🫡15
u/No_Mathematician299I don't have anything to add to the discussion other than thank you. Thank you, MGK_2, for helping us make sense of everything. Thank you, Cytodyn's team. They are a bunch of diamond cutters, working tirelessly. I even thank myself for holding on during the bad times.positive13
u/Lopsided_Roof_6640Thanks MGK for the breakdown. Let us see what the new FDA does with this data. CRC, TNBC, and now GBM would meet any definition of unmet needs. Hard to ignore a hat trick. Notice that Pancreatic cancer has popped up here and there in Cytodyn literature. Would not be surprised if it gets a mention in the next update.11
u/AggieEC3After reading through the original post and many of the responses there’s a lot to unpack here, but stepping back, what stands out most is how the conversation is evolving from what could happen to how this might actually work in practice. The breakdown around glioma stem cells and OCR is especially compelling. If recurrence is truly being driven by those “seeds,” and this approach is impacting the metabolic engine that keeps them alive, that’s not just incremental, that’s getting closer to the root of the problem. The idea of starving out the cells responsible for regrowth, rather than just cutting down the visible tumor, is a meaningful shift in how this disease is approached. Where it really starts to connect is on the combination side. GBM has been the place where a lot of otherwise successful therapies go to stall out. If the issue has been access, both physical and immunological, and that barrier can be altered, then it makes sense why pairing becomes the focus rather than replacement. “Prime and pair” isn’t just a strategy, it’s a different lens. The OCR data, the dose dependency, and the early signals around reduced spread all point in the same direction, but like anything in this space, it still has to translate clinically. That’s the next step that matters. If it does, then the implications go well beyond a single indication. Appreciate the way this was laid out, it helps connect a lot of dots that don’t usually get tied together in one place. And to build on the analogy… if checkpoint inhibitors are a high performance engine, and this approach is about finally giving them traction, then maybe another way to look at it is this… right now, the system looks like a luxury car with a manual transmission, but no clutch. All the power is there, all the engineering is there but without that missing piece, nothing engages the way it’s supposed to. If this data holds, we may finally be looking at what allows the gears to actually connect. Thank you MGK_2 for continuing to bring clarity, put in the time, and connect the data in a way that moves the conversation forward.11
u/CytomightThis is turning out to be a BIG DEAL‼️😁😆positive10
u/Practical-Archer-124[deleted]neutral8
u/jsinvest09As I was reading that I could literally hear the excitement in your voice MGK.. are time is here. Are time is now?So, enjoy everyone, because here it comes...7
u/jsinvest09Good morning6
u/sunraydocThanks, MGK, you are the rock. That OCR reduction in the hypoxic tumor center really stood out for me, Yet another previously undiscovered MOA.2
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62r/exjwNew Cancer and Autoimmune Therapies Available that were Previously Off Limits fo...Slow_Watch_3730970%4469.7stem cell therapy2026-03-25↗
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u/Darby_5419And of course PIMI's are waiting for "clarification" from the GB overlords, to ensure they have permission to save their own lives in these private health matters....30
u/RhiboflavinImagine what it must feel like, to have a sick helpless family member slowly dwindling in front of you while you frantically search for any answer in watchtower garbage. By the time you find the answer is no. Your family member is 'moving on' and you wasted the few precious days you had with your loved one, all because 'men' decided on what the light says in this current decade. Disgusting.15
u/Diligent-Swimmer1966I work in dentistry. We have a procedure we call PRF or platelet rich fibrin where we draw blood, spin up a clot and use it in the socket when we do extractions on high risk or immunocompromised patients to help them heal faster or improve the overall prognosis. Witnesses adamantly have refused this proven therapy and some diabetic patients took months to heal up instead of weeks. I'm curious if those same people will have a different perspective when I see them again.13
u/Short-Complex-2410It pisses me off that people have lost their lives due to GB overreach. Recently a new woman in my parents congregation was diagnosed with cancer, I'm grateful she might be able to receive real treatment now. It seems like all lives lost before were in vain. Why didn't this "correction" come sooner? They will never ask.10
u/Pale-Cod3749Wow. Thanks for this and it absolutely should be its own post, if not pinned. It shows all the treatment options that were forgone by unaware, uneducated, obedient JWs facing death or excruciating pain or a longterm terminal illness. They thought they were obeying Jehovah’s explicit command, only because the GB forced them to obey and forbidden to research anything non on the JW dot con site. And if this is all about not disrespecting and wasting/improperly throwing out blood, if they’re saying they can remove their blood from their body and store it in bags in a blood bank, in advance of their own surgery, but don’t end up needing it… What about all the JW blood that’s not able to be used by anyone, according to the GB’s un-thought out new “exception”? With them adding in their own legally-protective, “blame-shifting” clause of “according to your own conscience” and a lowly, devout, obedient JW realizes that they did this thing that’s kinda unclear whether it’s ok with Jehovah, maybe their conscience will gnaw at them for having ended up “wasting blood” instead of just trusting in Jehovah (like those martyred children sacrificed for their Awake! cover were forced to)? It’s all such obvious bullshit. I hope they’re lurking in here and getting the message loud and clear that they need to just drop it all and not do this parsing out “spiritual food at the right time” or on Jehovah’s timing and just do the right thing and stop it. Now. Today. Pfft.9
u/Ancient_Team_7007This is where that statement — “the list of treatment options continues to grow” — really changes meaning. They’re not talking about relaxing the ban on blood transfusions. That part hasn’t changed. What they are doing is widening the category of what counts as “acceptable” by quietly absorbing newer medical techniques into the framework. So instead of saying “transfusion,” they avoid that word instead saying "give back", focusing on alternatives — many of which, in practice, overlap with what people would traditionally associate with transfusion-related care. It’s a linguistic and doctrinal balancing act: Keep the core prohibition intact Acknowledge modern medicine is evolving Reframe newer therapies as individual conscience decisions So the headline stays the same, but the application becomes more flexible over time. That’s why the wording matters so much(they say "clarification" instead of "change"). It’s not a change in doctrine — it’s an expansion of what can exist around the doctrine without appearing to contradict it. Mind blown!!9
u/ExWitSurvivorAnd all of the hundreds of JW’s who refused these treatments…who would possibly be alive today!!!5
u/goddess_dixthanks for sharing this information. for those of us completely uneducated in this area (i.e. me) i was wondering about this specific thing what treatments it opens up for people4
u/BolognaMorrisIVI'd caution against celebrating just yet. From what I'm reading, therapies like CAR-T or Stem Cell transplants still require donor blood and platelets to keep the patient alive during the recovery phase. While witnesses can now store red blood cells for up to 42 days, the platelets only last 5 to 7 days. It's apparently not possible to bank a month's worth of platelets, so they will inevitably run out during the recovery phase and die without donor transfusions. We really need somebody with actual medical expertise to go over all of this before we start popping the champagne.2
u/brooklyn_bethelI get what you mean, but it only affects countries which offer healthcare for free, so you don't have to do anything to get it. Otherwise if getting a therapy involves any action or money, Jehovah's witnesses are never going to apply for it. The cults teaches them to be useless penniless slobs. The cult teaches them to never care for their health or for themselves in general. The cult teaches and desperately wants them to be poor, uneducated, lazy and dumb. The cult brainwashes them into thinking they are going to live forever after death, so they don't take care of themselves and die from any smallest illness. It's ridiculous how destructive and evil the Watchtower cult is.2
u/EginmundisGreat post, useful research 🙏 thx2
u/Firm-Instance5489Pimo here, I had a family member that was very close to me die several months ago bc their lymphoma came back. They would’ve had access to much better options for treating relapsed lymphoma if weren’t for the GB. I had to watch them suffer due to ineffective treatments for years, when they could’ve had access to treatments that are clinically proven to be much better and have very high success rates. Clarification my ass, it isn’t clarification when it was pretty damn clear the org was against these treatments previously. How dare the GB not acknowledge any of the lives they negatively affected with this doctrine. I absolutely despise them.2
u/ClosetedIntellectualThat's pretty cool, actually. I didn't realize that all of those therapies use your blood.1
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63r/kvssnarkerIndy and Woody out to pastureCrafty-Election-7077710%6969.7PRP knee treatment2026-03-04↗
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u/Illustrious-Ball6437"They're still a little bit contracted" A LITTLE BIT!? He is 23 days old today and yeah hes better than he was right at birth but at over 3 weeks old? I know hes structurally OOTK and that wont go away but aside from a few days of splinting and restricting exercise, they haven't done squat with this poor boy. How long until theres permanent tendon damage from lack of treatment? Thats a genuine question for those with more experience.56
u/Crafty-Election-7077Let's not forget the comments she made about Charlotte44
u/denastraListening to the video she sounded like she will breed Charlotte again43
u/Only_Feature1130What I hear- blah blah blah if he looks like he gonna be too damaged we will move him out- but till then I will milk content, then cry when shit goes wrong. Blah Blah Blah43
u/Professional_Size535This poor baby. Every time I see him he looks like a dang spider. Or the mind flayer from stranger things. I will never unsee it.40
u/Fit-Idea-6590Again, this foal is on Equioxx and still can't really stand up in one motion or lay sternal. His legs are a mess. He's not as lax behind now so maybe it's time oxytetracycline for those contracted tendons because his front legs are zig zags. The longer she waits the less chance he has in ever being `normal'. If she can build a ridiculously large outdoor arena that she'll hardly ever use, why can she not get her husband and his crew to make a nicely graded and rock free dry lot? Or several? Why are these horses rattling around over rocks? Charlotte just makes me sad. That's probably as much attention as KVS has given her since losing the foal. I'm still perplexed at how she managed to yank a foal out of her with the placenta that Charlotte `never even saw'? WTH actually happened that night?34
u/PuzzleheadedToe7Noticable ballerina syndrome. HOW is this improvement?33
u/Frequent_Chipmunk410Do his hocks look absolutely massive to anyone else or is it just me?29
u/QuestionableBest"stallion" material 😬. I've been saying since the moment Dr. Matthew's said he wasn't sure about what was the right steps, I would have had them at the clinic for supportive care for him for any chance of him being normal. Why she hasn't, I don't know! Losing out on foal content? I don't know but it's awful29
u/Frequent_Chipmunk410What does she mean Charlotte will have her time???? She caught herself saying more and stopped. Why would you breed that mare again when she’s got a super stressy temperament and isn’t much on being handled??28
u/CleaRaeOmg his legs and the lack of grass. If any horse needs some lush green grass free range. She is going to eat that scant patch in days.27
u/denastraAll 4 legs are messed up, I go between his poor front legs to his messed up back legs/hocks. Poor sweet baby has an owner with a shit ton of money to get him the best care and nope he isn’t getting it23
u/Rare-Attitude-3100Can we clean the sticks out of the pasture?!? Smdh13
u/Middle_PilotI just did a bit of a deep dive on Carpal Valgus, based on what OP said above. This really seems to track with what was in the Case Report from MSU. <image> https://www.vetmed.msstate.edu/sites/www.vetmed.msstate.edu/files/presentations/6.30.17%20Valgus%20in%20the%20Foal%20%28Austin%20Mobley%29.pdf13
u/Pr1nc3ssButtercupIt's painful to watch Woody, poor little guy. I do wish she'd take him up to Dr. Ursini. She's way out of her depth here.9
u/CapybaraCavyI always thought this breeding would be problematic but not to this extent. He really needs some specialist vet care.9
u/Redchickens18Has KVS said what her plans are with this one?8
u/Candid_Daikon4701Thank you for suggesting carpal valgus! I have felt for weeks that at least one of his front legs was crooked but couldn’t put my finger on it, I just really felt in my gut that this was more than being contracted and lax.8
u/Ok_Grab_6945Mare and foal need to head to Dr Ursini for appropriate care asap. Can you imagine dr ursinis face seeing this dumpster fire turn up.8
u/CalamityJen85I wonder if she’s consulted Dr. Ursini about it 🤔 I’d be interested to hear her thoughts on this little dude before something that would be treatable becomes permanent.8
u/Snarkie-McSnarkieOooff! <image>7
u/Fire_Tiger1289I hope he’s just an ugly duckling who will grow into his spider legs. Right now he looks odd3
u/Civil-Tumbleweed-104His front legs are literally Z's.... It's so painful to watch! His back legs do seem to have improved some but damn he's a mess the poor thing 😞3
u/Empty-Stretch-5615He does not look comfortable2
u/FinanceOk7303This little guy will end up needed a check desmotomy2
u/New_Suspect_7173Wow, his legs are such a hot mess. I hope this poor guy ends up being able to have a comfortable life as a pasture puffs. I don't think showing is in his future. I just want him pain free.2
u/Maleficent-Flower607His high heels look so painful2
u/Next-Outside-998If this was your foal, how would you be treating the symptoms?1
u/NumerousLeader6789Dr.Mathew did say it would be over a month or more before he looks “normal” changes don’t happen fast when his legs were in such rough shape. They might even wrap them again if nothing is improving.
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64r/avfcPercy: Aston Villa are the feel-good story English football needsKanedauke1050%3969.6PRP knee treatment2026-03-24↗
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u/Deep-Sun-3432Quite staggering that we are in our current position. The penalties and most fouls stats are wild. Think we might be a bit too nice so our accomplishments are even more surprising. Very curious what Olabe and Emery can go do together in preparing for a CL campaign.36
u/arenarossThe fouls thing vs penalties & red/yellow cards issued is ridiculous and the sort of thing where if it happened to Manchester United the world would now have been sucked into an eternal void to stop us having to listen to them crying about it. I'm really torn. On the one hand I really respect Emery's approach to this, no excuses, we crack on. But on the other hand the big teams and players do kick off a lot more about this stuff and it undoubtedly has an impact in some degree. Dunno if it's time the club just needs to stop being Mr Nice and start fighting our corner more.28
u/K10_BayWhat's the second picture?10
u/cettypriminalKeyword: resiliency PS: Big up Sunderland. Don't think many expected them to be this good.8
u/slappymcmanmeatSo most fouled and least penalties? I’d like to see the stats on yellow and red cards awarded compared to that8
u/Astonishingly-VillaWe are a feel-good story, but its especially great to be feeling good as a fan after this weekend again as well. In terms of penalties, maybe we do have to make a bit more of a deal when we are blatantly fouled, but I suppose having such an approachable and respectable group of players comes with certain negatives. Realistically the responsibility is on the referees to make sure they are always fair and just regardless of the player reaction to fouls. Some referees are better than this than others - Anthony Taylor gets a lot of abuse and he's far from perfect but he's one of the referees that I've noticed just makes a decision based on his interpretation of the rules and doesn't let himself get swayed by fan or player reaction. Would I swap a leader like McGinn for a player like Fernandes if it meant we get awarded an extra 5 penalties a season? Maybe I'm mental but absolutely no way, no.6
u/elmattydoor123Rogers, in particular, is admired by Liverpool, Chelsea and Tottenham and selling him would relieve much of the financial pressure on the club. <image>5
u/BohrInRedditWhat's the 2nd infographic about? Edit: nevermind it's peno granted for this season5
u/PizzaplantdenierI'm playing devil's advocate a little with this. Crowding the ref, getting angry on the pitch, would involve an attitude shift that is perhaps out of line with the "mental structure" of our team. We play best as underdogs, try hards, head down get on with it types. Clicking into gear with determination. Our dominance comes thru this perseverance rather than any expectance. If we start running round like we deserve something, I think we'd only go and upend our self with blushes.  A few players dropped in with that arrogance, perhaps it could change, just like how it works with Martinez. But instructing the team to get in the refs faces I don't think would do us any favours mentally.4
u/bambinoquinnWeve talked about not getting penos, looking back with 3/4s of the season gone, are there any key stand out pens not given people can think of? I know there will be some, but my brain is like empty right now I know tammy vs brighton will be mentioned. I think its dumb defending and very risky, but because we scored 10 seconds after, im not hugely bothered on that one. Could have been given, but I dont think its some ridiculous miss. I have a feeling there was a handball vs someone when a shot was going on target, but my mind is blank3
u/Kanedauke[removed]3
u/ThisusernameThenFUCK Pauline2
u/mjmilianWhat does the 2nd graph represent?1
u/three-4-truthTbf, we rarely get in the box enough to have penalties. How many times have players "taken on" defenders in the box or tried to get past them? Rogers might buckle under minor contact looking for a pen or after a player gets the ball, but I can't really recall any blatant/questionable pens not given?-4
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65r/lupusWhy436irish770%5769.5PRP knee treatment2026-03-10↗
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u/Fun-Manufacturer4131Sometimes it doesn't show up in the blood but could still be a lupus flare20
u/asiaticosideMy gosh. Mouth and scalp sores and they don't think you're in a flare and don't understand why you'd be in pain??? That seems so odd to me, although I admit I don't know nearly enough about lupus yet. Would love to hear other people's opinion/education because I am in shock.17
u/emptyjadeI'm sorry you're going through this. I've recently realized how important an antiinflammatory diet is. I don't know what you're eating, but I'm currently eating my way out of a flare. Be sure you're getting sleep and staying hydrated. Get your electrolytes, it helps with my pain. Hope things start getting better soon.16
u/MiserableSun9142I’m sorry you’re feeling this way. I totally understand. Sometimes I feel like the treatment is just as bad as the flair up! It’s really not fair we have to deal with this I feel like there is no good option 🙁5
u/redhood279Blood work isn't the be all end all! (((Hugs))) Skip pain management, unless you want to go, and find a new doctor! Your current treatment is obviously not working well enough.3
u/Dream117I'm sorry you're going through it rn, I'm in the same boat and I have to wait until April to see my rheumatologist again. They also couldn't find anything so it's time to play Russian roulette with meds now3
u/Pale_Slide_3463Before my worst flare I was in pain with my joints, was so sore and stiff, I started getting my hive rash lupus skin flare along side it. Went to my rheumatologist said something isn’t right, so she did blood tests and my ESR was 40 and my CRP slightly raised but everything else seemed “normal” I kept telling her my ESR when I’m stable isn’t elevated, but “your bloods are fine” 2 months later my antibody’s went from 28 - 395, ESR was 100 and CRP was 60. Ended up with hair loss, joint swelling, my vitamins started crashing, chilblains, ulcers, rashes, just some of it and then I started leaking protein, Don’t give up with them, I was annoying my doctors so much. I was right in the end but it was horrible, just look after yourself and don’t give up the fight. I flared on MXT, steroids and ended up in hospital for 3 weeks staying a biological, they wouldn’t let me go home till I was 100% stable.3
u/chefebony2021🫂2
u/Outrageous-Fruit3433Ugh so so sorry to hear you’re going through this 🫂 not nonsensical at all and I’m happy we’re a community everyone can vent to. Sending lots of love and understanding doctors your way. A rheumatologist I was seeing for a while said sometimes lupus “hides” during a flare, so bloodwork will frustratingly be normal. Bleh.2
u/Substantial_Escape92Mine will never say it’s from lupus. But I bet money, it’s the lupus!1
u/Brilliant-Lime-6383Im suprised he isnt offering you prednisone, even for a couple weeks. I know it sucks being on but its important to still keep inflammation down and that will help with some of your pain. I know something that I like to use is called sulferzyme. Its from young living and it actually helps me when my joints hurt. Its a natural product. Im sorry your suffering friend. 😔1
u/Leelulu905I have heard that cutting dairy can help with the mouth sores. I know that your diet is so limited that might not be possible. Using a topical antibiotic on my nose sores has decreased pain for me because they would get infected. I know that rheumatologists hate to change your biologic when your labs are good but I agree you need something. The pain management clinic I went to offered a variety of approaches to pain and I did find it helpful. They offered nerve blocks, nerve ablasions, Botox but also classes on diet, sleep, meditation. I hope that you can find relief.1
u/m0ther_0F_myriadsNot nonsensical at all. I think you will find many here have a had similar experiences. I was just punted to the Mayo clinic by my rheum because my inflammation markers are fine, when I am quite obviously not fine. All of my support to you. I know this is one of the hardest parts of lupus...waiting to get better and not knowing what to do to get there.1
u/LymnicaI was just moved up a step in therapy without abnormal bloodwork. I have had easy bruising (hematology workup normal, suggested systemic process), joint pain, mouth and nose sores, worsening autonomic nervous system symptoms and lung inflammation that wound up being asthma. My doctor listened to me when I said I have felt terrible and the specialists ruled out other options. She never hesitated to believe me and I think it's important to find a rheumatologist that treats the patient, not just the bloodwork.1
u/Horror_Struggle226Have them check you for other autoimmune disorders. I have multiple and my rheumatoid arthritis and psoriatic arthritis pain is different but similar to my lupus issues.1
u/ATXtoI think you need to find a new doctor1
u/AutoModeratorThis is a Diagnosed Users Only post - only members with diagnosed SLE, UCTD/MCTD, or CLE/DLE flair can comment! I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/macadamianuttThe constant pain and discomfort is soooo draining. It sucks. Bloodwork doesn’t tell the full story! Have you ever tried low dose naltrexone? It takes the edge off the joint pain for me.
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66r/4bmovementWomen in History: Ruth Gordon Schnappmullatomochaccino6860%369.4PRP knee treatment2026-03-29↗
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u/mullatomochaccino**Note**: Click the *History* icon at the top of this post to see all our user contributed women's history posts. You can also search for posts by typing *flair:history* into the search bar of this sub. Our support and respect to [u/Substantial-Barber10](https://www.reddit.com/user/Substantial-Barber10/) for her ongoing series: **The Matilda Effect (Lost Women of Science).** • ⁠[**Matilda Joslyn Gage**](https://www.reddit.com/r/4bmovement/s/s7WIldDKz4) **(1826-1898)** \- Pioneer Radical Feminist; The Matilda Effect • ⁠[**Mileva Marić**](https://www.reddit.com/r/4bmovement/s/N8UV2CIFzf) **(1875-1948)** \- Theory of Relativity; Brownian Motion; {1 Nobel Prize} • ⁠[**Ada Lovelace**](https://www.reddit.com/r/4bmovement/s/rGVr2FKTVc) **(1815-1852)** \- First Computer Programmer • ⁠[**Dr. Elizabeth Blackwell**](https://www.reddit.com/r/4bmovement/s/qIJBvfJ6MV) **(1821-1910)** \- 1st Formal Female Doctor in Modern, Western Era • ⁠[**Dr. Rosalind Franklin**](https://www.reddit.com/r/4bmovement/s/bkK4TeXGGh) **(1920-1958)** \- DNA Structure, Virus / Vaccine Research {2 Nobel Prizes} • ⁠[**Alice Ball**](https://www.reddit.com/r/4bmovement/s/IpQbAwJDkE) **(1892-1916)** \- Developed Cure for Leprosy • ⁠[**Dr. Chien-Shiung Wu**](https://www.reddit.com/r/4bmovement/s/oIWpGeER53) **(1912-1997)** \- Nuclear Physicist {1 Nobel Prize} • ⁠[**Lisa Sauermann**](https://www.reddit.com/r/4bmovement/s/ffIfQZD4Q3) **(1992-alive)** \- Multiple IMO Gold Medals \~ Credit: [u/Friendly-Ad-3961](https://www.reddit.com/user/Friendly-Ad-3961/) Other entries in my own ongoing series highlighting accomplished women and historical feminist movements, **Women in History**. • ⁠[**Assata Shakur**](https://www.reddit.com/r/4bmovement/s/d3aRxknfoW) **(1947-2025)** \- Revolutionary; Founding Member of BPP & BLA • ⁠[**Franca Voila**](https://www.reddit.com/r/4bmovement/s/iJl0bT7in0) **(1948 - Alive)** \- 1st Italian Woman to defy “Marry-Your-Rapist” Law • [**Sushila Karki**](https://www.reddit.com/r/4bmovement/s/vk8BiPFFfw) **(1952 - Alive)** \- 1st Woman to Head the Government of Nepal • [**Kathrine Switzer**](https://www.reddit.com/r/4bmovement/s/TGLEqlMyBf) **(1947 - Alive)** \- 1st Woman to Complete the Boston Marathon • [**Dorothy Day**](https://www.reddit.com/r/4bmovement/comments/1plyx1t/women\_in\_history\_dorothy\_day/) **(1897 - 1980)** \- Suffragette, Journalist, Lifelong Activist • [**Dr. Mae Jemison**](https://www.reddit.com/r/4bmovement/comments/1pdqbkw/women\_in\_history\_dr\_mae\_jemison/) **(1956 - Alive)** Engineer, Physician, 1st Black Woman in Space • [**Claudette Colvin**](https://www.reddit.com/r/4bmovement/comments/1rayh46/women_in_history_claudette_colvin/) **(1939 - 2026)** Caretaker, Community Activist, Catalyst for the Montgomery Bus Boycotts • [**First Video Editors Were Women**](https://www.reddit.com/r/4bmovement/s/TPjNZ2W6M7) • [**1970's Feminist Vandalism**](https://www.reddit.com/r/4bmovement/comments/1m5ohsz/women\_in\_history\_1970s\_feminist\_vandalism/) • [**Lesbians and Pride**](https://www.reddit.com/r/4bmovement/comments/1l57zhk/women\_in\_history\_lesbians\_and\_pride/) • [**Women Against Pornography Protests**](https://www.reddit.com/r/4bmovement/comments/1kpy7pc/women\_in\_history\_women\_against\_pornography/) • [**Liberation Day: Women of the Italian Liberation Movement**](https://www.reddit.com/r/4bmovement/comments/1k8eeq9/women\_in\_history\_liberation\_day/) • [**Black Friday: England's Radical Suffragette Movement and Society's Violent Response**](https://www.reddit.com/r/4bmovement/comments/1qduo82/women\_in\_history\_black\_friday/)19
u/harry-styles-7644Adding to the list of things I did not learn from my earthquake seminar!12
u/BelleCervelleThat T Shirt slogan is iconic .11
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67r/HormoneFreeMenopauseSocial pressure to go on HRT?Elegant_Cat_3644690%6069.2regenerative medicine2026-03-10↗
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u/Overall_Emotion8878if you feel so good, how would you even know if it is working or helping? without symptoms worth targeting it doesn't seem worth the potential risks.50
u/Away-Potential-609I've been on both sides of this because I didn't go off HRT by choice. Before I was diagnosed with cancer I was having a really rough time of perimenopause and was hopeful that HRT would help. In the short time I was taking it, I had mixed results. Some things seemed to improve, others were unchanged. If I hadn't had severe symptoms I don't think I would have considered it. Regarding disease prevention... even when I was more optimistic/enthusiastic about HRT I saw that a lot of the purported health benefits were heavy with confirmation bias... the data that HRT prevents things like heart disease and dementia is very inconclusive, but if you want HRT to be a heroic remedy then why not play those up. Meanwhile the cancer risk is not zero. The survival rate for breast cancer is significantly higher in post-menopausal women because lower-estrogen is protective, and women who take HRT are forfeiting that benefit. Breast cancer risk skyrockets after age 45 and is even higher after age 65. Some pro-HRT people like to tout the survivability of breast cancer, but surviving cancer does more damage to the heart, brain, bones, etc. than HRT could ever have prevented. All that to say, the claims of disease prevention are over-simplified and leave out the real complexity of disease risk as we age. No one can know in advance whether the diseases that may come for you are the ones that HRT might reduce vs. increase your risk. Knowing what I know now, if I had made it all the way to my late 50s with few menopause symptoms, I would leave HRT to those who really need it for their quality of life.44
u/NoneOfThisMatters_XOI didn’t go on it and I feel like other subs downvote you for that. There really is a lot of pressure to do it.37
u/Winter_Bid7630With RFK Jr. and therefore the FDA pushing for the removal of black box warnings on HRT and also citing decades-old research to justify its widespread use, more and more women are giving it a try. It's also really trendy right now with a ton of social media influencers claiming dramatic health improvements from taking HRT. There's a shortage of estrogen patches right now because of this surge in popularity. My doctor tends to agree with Dr. Jen Gunter and thinks HRT is wonderful for people who are dealing with severe menopause symptoms, but thinks there isn't enough research to justify its widespread use. Like any medication, it comes with risks. So, for someone like you, who is doing really well, why take on those risks when many of the benefits being pushed by RFK Jr. and social media influencers aren't proven by research? I've been in perimenopause for 8ish years and feel pretty great. Any issues I've had have been improved through vaginal estrogen cream, exercise, and improving my diet. I've had a couple of night sweats, but the only hot flash I've had was after my last glass of alcohol, which was almost a year ago. I rarely take vitamins, get enough sleep, meditate, and feel pretty great. I'll get on HRT if that changes, but I don't take medication I don't need.34
u/scoutiedalThe studies on the health benefits of HRT are very inconclusive. Really it’s your choice. The best evidence is around bone loss but diet and lifting are very important in prevention as well. If you feel great go hormone free. I use vagianl estrogen only for GSM. I feel pretty good too.31
u/Curious-External-7It sounds like you already live a very healthy lifestyle. If you're feeling well, I wouldn't mess with that. I've seen too many comments from the other sub about the troubles some of them have dialing in the correct dosages.23
u/Zoinks222I’m confused why anyone is pressuring you to take hormones since you don’t have any issues with menopause.16
u/4travelersMom 94yo, Sister 76yo, Sister 72 yo have never even considered HRT and all have lived to tell the tale.16
u/Agitated_Eye2638HRT is not compulsory. Do what is working for you.15
u/10MileHikeI am post menopausal by over a decade. I;m going to be very frank in this post and hope I do not offend anyone. As that is not my purpose. All the women in my family live to between 92 and 100 and none of them took HRT. I do believe quite a bit in the genetic predisposition to many things, which is why I think its important to look thru one's family history. There are things we cannot fully control...they are part of our makeup. I would never discount any of the positive effects of HRT therapy for anyone doing it. But on the flip side, I don't want to be nagged and proseletized to about doing it. And the pressure the OP describes is very much alive out there. Reading deeper between the lines, it seems that many women are terrified of aging. I am not. (I discuss a bit about "mood" further down in this post.) A lot of both physical AND psychological experiences do have very much to do with how you frame things, and one's deepest and almost "unconscious" beliefs about aging as a woman. I work on myself to dispel all the myths, and belief systems that don't ring true for ME. I am not worried about dementia or heart disease, since in trying to get my lipids profile as close to perfection as possible, I started taking one of the safest and most well studied meds, a mild statin, which research also shows great great promise in preventing dimentia and alzeimers. My microbiome has improved because I am now getting >30-40g of fiber per day, and for my LDL-C and Apo(B), I consume < 10-15g of Saturated fat, which has also kept me at pretty much the same weight I was at in my mid 30s, and my cholesterol profile healthy. I also walk 3 to 5 miles a day 3x a week and swim every other day in summer.....less chance of me falling and breaking my hip because I work on my balance.. I am a huge believer in physical therapy and "movement". For both my heart, musculoskeletal system, and mood. I place more importance on not suffering a stroke, or heart event, than I am about hot flashes, mood disorders, etc. I've lived long enough to take those things in stride, life is an up and down event.....I never expected to feel at my age the same as I did when I was 30. I do accept some of the deficiencies of aging.......because there is no way around it. And I have never been a woman who worried about aging, at all. I just accepted that we do age. I always promised myself when I was younger that I wouldn't become obsessed about it. And, this may offend some: I actually think that at least "part" of the emotional distress some women experience during menopause may be directly related to how they feel about aging. And that might be good to explore. Therapeutically. I am not interested in adding any extra risk to my life... and I do believe there is some heart health risk to HRT for some people. But I am also very intentional about living a healthy lifestye and eating properly. As well as doing all the important "preventative" healthcare things that people over 65 should be doing. I get a full body skin cancer check, yearly, no matter what, for instance. I "do" however use vaginal estriodol, which is non systemic and helps a LOT with dryness, UTIs, etc. Finally, my neice had triple negative breast cancer, (the worst kind of BC), and the first thing the oncologoists (modern oncologists, in one of the most famous universiity hospitals in Calif) asked her was if she was taking hormones. Not saying it does, but there may be a relationship. That made me nervous. What she went thru for 4 years I would not wish on anyone, so maybe I also have a slight fear of the "possibility", however remote, of HRT and certain cancers. But its not an argument I even want to have. I just feel, intuitively, that I didn't want to get on HRT and so, I did not. And yes, I have noticed a very strong push in social media, that is even creeping into other health topic subs, haivng nothing to do with menopause or HRT. And that almost feels like marketing pressure or at least pushing an agenda. But I also dislike those commercials that show older people in fields of wildflowers, frolicking as if they were 20-somethings, becuase I don't think that is "realistic" for many people. I have my aches asnd pains, just like many others do. I used to play tennis 4x a week.....I can't do that anymore, so I do other things that I CAN do. I don't think we can control everything. At my age, I have become a more patient and accepting human, and my overall attitude is "I do what I can." That is what everyone should do. Do the best you can do for yourself, that aligns with YOUR belief system, values, and deeper intuition. Examine it and decide. Then, carry on with confidence and belief that you made the right decision for yourself. Just smile and thank the friends pusing you about it, and tell them, you are glad they are getting relief, but you are pleased with your decision (if you so decide that way).15
u/BuffalippoI could have written this! I also feel the social pressure from my friend circle despite being extremely active, fit, and healthy. I basically have no reason to go on HRT but I feel immense pressure to.11
u/Reiki-RakerAdrenals are supposed to make the transition smooth but a lot of people haven’t taken care of themselves and their adrenals are fried. WHO released that birth control is top level cause of cancer last week. I wonder how long before HRT is the same by WHO. I do not trust one thing our Federal Death Association approves of.11
u/GrdngirlMy boss is on the highest does of HRT and while it helped with her sui@idal ideation. She still had anxiety and sleeps like crap. So it’s not all roses on the other side. I’d i’d say try it if you were completely miserable and it was affecting your everyday life. But you seem to be doing pretty well and you don’t seem to be too bothered by that many intense symptoms. So I would just do what you want and stay off of it. It’s not absolutely necessary to take HRT.10
u/franzvonstuckPlease don´t get me wrong, but I have to say it very harshly: I refuse to believe, that everything will be fine once you take HRT. It is massively the lifestyle, which influences the way you age and many people don´t want to or cannot do the work or change their habits. I personally cannot take HRT due to other conditions and given how I badly reacted to my own hormones all my life, I wouldn´t want to put any chemical hormones in the mix. Currently, Im roughly 6 years into perimenopause with poor sleep, hormonal migraines due to peri, osteopenia and a lot of histamine issues and mast cell activation. For many things, that HRT claims to do, there are non-HRT options you can do: Strenght training, eating whole foods with the right macronutrients, prioritize sleep as much as you can, move more, reduce stress. This takes a lot of effort and I do wish, a magical fairy-dust unicorn pill existed, that would do the work for me. Due to my constant exhaustion, I really don´t feel like putting in the effort most of the time, but I cook with whole foods, track my macros, try to get some exercise like walking, pilates and yoga, drag my tired body to the gym and try to sleep as well as I can in this hormonal chaos. I live in Europe and unfortunately, this trend has spread here although many women still don´t want to take HRT. I see mostly women, who are afraid of ageing taking it. I have colleagues, who take it and think, it is the fountain of youth. They don´t eat enough calories, one likes red wine a lot and the other one even tanned a lot (still does). Both have wrinkles and saggy skin, which proves, that HRT is not the magical pill for youthful skin it claims to be. Unfortunately, I know of at least 2 women, who got cancer on HRT after menopause. One got breast cancer and the other one got the pre-stage of cancer in her uterus and had to get a hysterectomy. Due to the PR and media coverage, that HRT gets, I would be lying, if I didn´t admit to be scared of osteoporosis, heart disease and dementia. Every doctor and menopause specialist recommends it nowadays. But it is too simplified and one-dimensional sometimes as you can get osteoporosis from other things than just the loss of hormones. What about your vitamin d, your calcium, your muscle strenght and type of workout? And some illnesses can cause osteoporosis like my mast cell activation. It´s hard, but I don´t want to take HRT and only time will prove, if my decision is right for me.10
u/Cat_From_HoodTime to find some new friends 😂.  Why would you take something you don't need?  It might make sense if symptoms are bad enough to trial.  Personally think it's better to focus on general health to make things go better.9
u/ServiceKooky1323A lot of the Dr influencers who sell books recommend it (Vonda, Haver).8
u/blondy168HRT doesn't solve everything, that's for sure - I'm listening to a podcast of Dr. Mary Clare's right now, she is on higher doses of estrogen (patch at at least 1.0 I think) and 200 mg Progesterone and says she wakes up at 3 am without fail and can't get back to sleep - doesn't sound like a ringing endorsement of HRT to me. I found the same thing tried it once and it did nothing but wrecked my sleep. My experience.8
u/evefueI have seen it, too. I wasmicrobiology. In it for brain health, but my doc said that there isn't much evidence to support that it is preventative against dementia. I otherwise feel pretty good. I am not against it and am open to it if things go downhill for me, but not for now. My doc did say she was pushing people to take care of their microbiome.5
u/AlinaNightroseI didn’t do it either and yeah, the sub acts like you committed a crime. Exhausting.5
u/rulytempestI wish it wasn't so but I've tried HRT twice and both times had to give up and remove the patch. It always seems to work so well for the first week or so. Like I feel amazing! Anxiety disappears, I'm clam and sleeping well. Then the side effects of the HRT start to ramp up. Instead of calm I feel like Weepy PMS, wanting to eat everything in sight. And this last time the breast engorgement was crazy. I felt pregnant. These are things I don't want to feel again at my age!! Many suggest I should just wait it out for a few months. But I just can't handle it. I suspect I have progesterone intolerance. I will say I have had great success with vaginal estrogen for prolapse and dryness.5
u/Thin_Risk7778As a breast cancer patient who can’t use HRT, I appreciate stories from people doing very well without it :)5
u/Meesha1969I think there is a world of difference between HRT from years ago and HRT today. I think it’s important to trust your inner voice. Being sceptical is okay but don’t let yourself suffer unduly. I’m unable to use any kind of hormone treatment. I would love to try it. I have had hot flashes every two hours for over 10 years and haven’t had a full nights sleep in all that time. I sooo want to get a full nights sleep if for no other reason than to be able to control my junk food cravings, but also, the fatigue and brain fog are so severe i feel incapable of doing most things.4
u/Brilliant_Meet_2751I agree, I’m 48 & feel good I do have random hot flashes & zero sex drive but I don’t feel it bad enough to try HRT’s. I take Black Cohosh a few times a week it helps w/hot flashes. Sex drive I have found anything to help w/that one yet.4
u/Affectionate-Map2583You sound similar to me. Why mess with what's working? I never tried HRT because I went through menopause without too many issues, all while not going to the doctor for a few years due to needing to find a new doctor and avoiding their offices in general during Covid. By the time I went, the doctor said "are you in menopause" so I said yes, and she said "and that's going okay for you?" (yes) and that was the end of that conversation. I have seen stories on here from women who had issues with being on the hormones, so that's definitely a possibility.4
u/Marvellous_WonderHave you though about NEM for reducing the chance of bone loss. I have been using it and it has really helped to reduce my joint pain. I also take marine collagen.3
u/AlinaPetalwindEvery body is different. What works for the majority isn't a universal rule.3
u/AmaraStarcrestI didn’t do it either, and people definitely downvote you for that2
u/AylaMoonpetalDidn’t go on it either, and the downvotes came fast.2
u/cookingismythingI didn’t go on hormones for a while but then the symptoms became too much and was affecting my everyday life. The night sweats were bad but mostly the mental fog and fatigue. I couldn’t function at work. So I’m on HRT now it has helped me tremendously but there’s no judgement from me. Peri lasts so long and symptoms come and go. Women have done it without help. Women have done it with help and women have had some help for periods of time. You need to do what’s best for you.1
u/[deleted]You can’t even go to any skincare sub these days, under almost every post there’s a suggest to start on HRT. Some truly believe it’s some sort of fountain of youth and makes them look 15 years younger. Yeah, riiight.1
u/themainkangarooI think the only pressure is on-line. I am 63yo, use estrodiol cream but have never discussed this with friends my age, so there no pressure there. I have no sisters & my Mom was never on any hormone (she 90yo). The HRT push is an annoying on-line, media thing in my experience & the only reason I see it is within Osteoporosis discussions -- much bigger push to take bisphosphonates from doctors once they see a Dexa scores below -2.5 & sometimes above that if the woman has had fractures.1
u/Acceptable_Iron_2080My mom is now experiencing the repercussions of never taking hormones through menopause and beyond. If she had to do it all over again, she would take it. Go to a functional medicine doctor that will test your blood thoroughly and take their advice.
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68r/DryeyesAfter 3+ years of battling dry eye, I'm finally medication-free and stable. Here...Educational-Prize-94830%4268.9PRP knee treatment2026-04-02↗
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u/2D617Love hearing all this - it’s encouraging. Can you discuss some of the dietary changes you made? I’ve made a lot of changes in my diet and I’m pretty sure it’s helping, but I’d like to hear about yours too.7
u/dolfinberryWhat are heated humidifying goggles? Thanks!6
u/victururuI want to try cyclosporine. How long does it take to work? I've been told it can take several months. Actually, i am with autologus serum. It helps, but i think cyclosporine will help me increase my tear production.4
u/GroundbreakingBig404Cutting onions does it for me3
u/Dra794Thanks a lot for sharing this great story! Very helpful3
u/rather_be_gamingThank you so much sharing!!! Its always awesome when a fellow dry eye sufferer has healed up. Gives the rest of us so much hope! I feel you on the climate change. My mom spends 6 months in the Philippines ( humidity is next level) and her dry eyes (kicked in around menopause) healed up.3
u/TaterOTI just started RF this week-glad to hear you had good results.2
u/redditjrmDo you use googles to sleep in? If so, any recs?2
u/morula2Do you know what your glands look like? Did you have a dry eye exam? Very happy to hear you’re feeling better2
u/Annual-Lifeguard7754Thank you for sharing2
u/Emotional_Banana3059can attest humidity difference is huge, moving from average 25% zone to 50% was big milestone for me as well2
u/No-Tree-1000That's great.  Im really happy for you that you found what works for you and came out the other end.2
u/KhaleesiakoseCongratulations on getting here! Can you share the product you used for the eye flushes/rinse? Why did you only trial PRP for a month? How long did it take for you to see improvement from Cequa?1
u/AnythingGlum2469What type of diagnosis did you get for your eyes, if any? Did different doctors recommend different procedures or give a different diagnosis?1
u/Senior_Sweet_9859How much time cequa take to show initial improvement?did you use any steroids with cequa?1
u/2213cheeseHave you heard or do you think Cequa works better than Vevye? I’ve been on Vevye for two years and haven’t had noticeable differences from it but stay on it with the idea that it might be helping inflammation in general.1
u/scifibookluvrI’ve been wondering about rebound on OTC. Haven’t looked in to…but since you mentioned. A real thing? Common? Doc suggested hourly DOc also suggested blue light glasses, but you mentioned red. (I’m seeing a new doctor soon).1
u/pink_dot34Which moisture chamber glasses did you use? Do they fog up?1
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69r/multiplemyelomaTen years agoHighyet1080%2768.6stem cell therapy2026-03-30↗
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u/per1sherWaking up is good! One day at a time. Thanks for posting this. I was diagnosed with smouldering MM in 2012 and have two transplants behind me. Feel pretty good right now and am very grateful.12
u/LonelyChampionship17Seven years for me. Still on maintenance but I work full time and have a good life. The gratitude does not fade.11
u/LeaStringPowerful telling and so happy you are here to write it. Ten years from back then on dex and one other drug only…you really beat the odds on SOC back then. I’m sorry you are in pain however. I hope you get reprieves from it with the help of palliative care. But to have no signs of disease now and off treatment for three years is something to be thankful for and celebrate. Taking wins when you can. I read your post to my guy, who like you was stage 3 with bone damage at diagnosis. He found it very interesting and hopeful. Back then when he asked, ten years was a good estimate for him. He’s now at almost 4. We’re hopeful for many more beyond the ten and feel good of his chances with advances in MM research and treatment. He was in extreme pain at diagnosis with several collapsed vertebrae, underwent ASCT, and still on treatment. Fortunately he feels good and without pain. Guess we never know what tomorrow brings but tomorrow does hold hope for better. Thank you for sharing your anniversary with us and we both wish you another ten at least. It’s encouraging to hear more stories of people living longer and longer lives.11
u/iNap2MuchAmen brother! Fellow MM patient here, bone marrow transplant last November and now recovering steadily. Glad for your recovery results. Hoping mine are the same.10
u/L31121Thank you for your story. I can only hope to make it at least that long. I'm going on 2 years since being diagnosed at stage 3 also.8
u/BrokenEffexThank you for posting this.  I’m 1 month post-BMT and 6 months post posterior spinal fusion from T9 to L1 with a corpectomy device at T11. I deal with pain every day, usually around a 7–8 out of 10. Right now, it’s my biggest source of anxiety. I’m 37, and it feels like the rest of my life may be heading toward pain management, which honestly scares the hell out of me. Your take makes it seem a little less severe than the picture my mind has been painting, so again, thank you.8
u/DeciduousEmuThanks for sharing I think I'm one of the fortunate few where they diagnosed me very early before I had any CRAB symptoms. Unfortunately my MM is considered high risk due to TP53 deletion from the genetic analysis. Hopefully I can get as many years as you.6
u/Fantastic_Fly_6434Thanks for your hopeful post. It means 10 years and beyond is doable for all of us. If you don't mind me asking, where is the pain coming from?. Bless you.4
u/Icy-Town-53559 years for me as of 4/7/17. I don't focus on it, and I think this is why I'm still here. Hugs to you all xox4
u/ShadowBard0962Thank you for sharing your story. 🫂🫂 Going on 4 years for me. Like you, I an in pain everyday all day, on Revlimid, but the cancer is in “deep remission”. I just saw my oncologist this past Thursday and he said I good stop the meds pending a negative bone marrow biopsy! So, wish me luck.3
u/Mommie62Good for you. I have chronic pain and a resource that helped me is an app called curable. They also have a Facebook group. Pain is a fun y thing despite things being repaired or healed the pain can persist but with the help of curable you can work in breaking down the established pain pathways . I wish you luck. My hubby has mm. He was low risk. Nearly 4 yrs post transplant and still on treatment. Doing well other than all his arthritis decking his joints. Awaiting shoulder replacement and had brutal foot surgery 5 mos ago3
u/WerewolfBarMitzvah09Thanks so much for your sharing your story. You're very strong. This gives me hope for my family member with MM.3
u/tofuraisinThank you for your post and I am so happy that you are cancer free!3
u/BB5erMy wife is almost 17 years post-transplant. Even off the Rev for a few months, here and there, the pain is more than it used to be. Like you, she works through it. Thanks for sharing your story.3
u/Myeloma-Fighter10 years is a milestone. I like seeing posts like this. It gives people like me hope. If you don't mind me asking, how old are you?3
u/AltruisticAccount909How are you able to be off maintenance therapy?2
u/Sad_Secret8253Thanks for sharing your story! sending lots of love and healing energy your way for the rest of your incredible journey 🙌🏻2
u/Sorcia_LawsonI had a very similar diagnosis story - broken clavicle, stage 3. I'm at 7½ years. But, my treatment ended up more complicated with more broken bones and other complications. The chronic and long-term pain sucks. But, similarly I'm appreciating still being here. Things with MM can change on a dime. For a while, I wasn't sure I'd make it to year 3 let alone year 7!2
u/Redneck-AstronomerI appreciate your post, as it gives me insight into my fight. Diagnosed over a year and half ago (MM IgD lambda, an unusual one), started Griffin induction right away and had ASCT four months into the treatment. It's been a year and three months since the stem cell transplant and am currently in the maintenance chemo with only Velcade. Pain is there, but I have a good palliative care physician as well. Wishing you all the best in the path ahead you.2
u/Mantisman51I was told it was a ASCT or palliative care. I couldn't wait to get the ASCT started. I'm glad you're doing well.1
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70r/immortalistsHyperbaric Oxygen Therapy (HBOT) significantly increases lifespan. Hyperbaric Ox...GarifalliaPapa960%3368.6stem cell therapy2026-03-04↗
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u/TheWatch83The time and cost are tough to swallow unless you are rolling in it and can have a hard HBOT unit in your house. Ive been tempted to do a 30 day therapy every day but its hard to spend an hour plus travel time back and forth to do it. Maybe sometime the planets will align and it will be close.16
u/Mission_Bullfrog3294Your comments make it sound like only three months of therapy is needed. Is that total? with no repetition schedule?6
u/Silky_MeatWhat is the investment needed to do this at a clinic versus buying the equipment for home use?3
u/ExerciseDear633Is this safe for patient stage 4 cancer?2
u/AllstarGERI have a chamber in Siegen, Germany If anyone is interested...2
u/Mission_Bullfrog329490 minutes at 2 atm 5 days a week! doesn’t that come with significant risk to your hearing? Anything more you can do than yawning and popping?2
u/JonaEnyaI already spoke about this days ago, Im doing this on myself already! I have a stack that will take us to 140 years, now...1
u/Cascadeflyer61I’m wondering if diving my rebreather gives me some of the same benefits? I breathe pure oxygen under pressure, although at deeper depths we mix air with the O2 to keep the O2 under 1.4 partial pressure to avoid oxygen toxicity. So it may have some similar benefits.1
u/LikeMrFantasticCool story, any cost effective methods?1
u/Phillip_CharlesIt didn’t extend Michael Jackson’s life1
u/[deleted]It's all fun and games until someone's autistic child burns to death.1
u/GarifalliaPapaBest scientific research: [1] Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Humans – PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC7746357/ [2] Hyperbaric Oxygen Therapy Increases Telomere Length and Reduces Senescent Cells – Aging-US https://www.aging-us.com/article/202188/text [3] Tel Aviv University Study Reports HBOT Reverses Biological Aging Markers https://www.eurekalert.org/news-releases/667837 [4] HBOT Prolongs Telomeres and Reduces Immunosenescence (Prospective Study Summary) https://www.x4oxygen.com/article/hbot-telomere-immunosenescence-prospective-study-2020 [5] Effects of Hyperbaric Oxygen Therapy on the Pathophysiology of Aging – PubMed https://pubmed.ncbi.nlm.nih.gov/34784294/ [6] Hyperbaric Oxygen Therapy and Mechanisms of Aging: Clinical Study – Aging-US https://www.aging-us.com/article/203701/text [7] Hyperbaric Oxygen Therapy for Healthy Aging: Review – PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC9156818/ [8] Hyperbaric Oxygen Therapy Effects on Aging Pathophysiology – Tel Aviv University Repository https://cris.tau.ac.il/en/publications/the-effect-of-hyperbaric-oxygen-therapy-on-the-pathophysiology-of/ [9] Hyperbaric Oxygen Therapy: Future Prospects in Regenerative and Anti-Aging Medicine https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1368982/full [10] Hyperbaric Oxygen Therapy Human Study Reporting Reversal of Biological Aging Markers https://o2healthlab.com/wp-content/uploads/2023/11/Hyperbaric-Oxygen-Therapy-First-Human-Study-Shows-Reversal-in-Biology-of-Aging.pdf
u/mdeeebeee-101Worked for Michael Jackson.
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71r/HotScienceNewsWorld's first stem cell treatment for heart failure approvedsoulpost2670%868.5induced pluripotent stem cells2026-03-14↗
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u/Big_Car_7725This sounds really cool!positive5
u/Jaxson-rosThis is a huge milestone for regenerative medicine. Seeing stem cell based treatments like this move from research to real patient use is incredible and gives a lot of hope for people with severe heart conditions. It shows how quickly the field is evolving. For anyone curious about how stem cells are already being explored in different therapies today, resources from places like The Stem Cell Club are worth checking out to learn more about current developments.positive3
u/fhwoompableCooperWe would have been farther along if we were allowed to used the stem cells that got banned, don't understand the ethical concern once the fucker is outnegative3
u/Lifeabroad86Awesome possumpositive1
u/hanginaroundthistownHoping this will trigger other companies or research groups, as well as funding, now that regenerative medicine is 'now', and thus realistically attainable. (Although things like MACI are also forms of regenerative medicine and have existed for a while). Also, this article includes a new drug for Parkinson's!positive1
u/lingonberry_gspWish they would try it out on Michael J Fox!negative1
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72r/EpsteinCan we talk about Don Huffines (current TX Rep AG candidate) new Zoro Ranch owne...Last_Spare990%2567.9regenerative medicine2026-03-23↗
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u/InterestSea4061This should be heavily discussed18
u/Either-Strain-1506Bumping and adding the original author link https://www.facebook.com/story.php?story_fbid=1311074210836987&id=100058032612092 And separate video summary by SweetandSaltyLin  https://youtu.be/VwqvbyMHX54?si=5v5NcuqSOeIKRsXt13
u/FrogsInASweaterJE purposefully curated intellectuals from the rationalist movement of the early 2000s for the purposes of greater exploring the potential behind transhumanisim. Founders of the movement and many prominent individuals feature in the files hundreds and hundreds of times in total. This includes people like: John Brockman Eliezer Yudkowsky Scott Alexander Nick Bostrom Peter Thiel [the big name most are familiar with] Michael Nielsen And so many freaking more with dozens of orgs linked to these individuals [and breaking research in transhumanisim topics, everything from cryogenics to what OP is discussing] also being discussed in-depth from creation to agenda Some of these folks got into politics, and some got into finance and investing. All of which need to be questioned because this was a large part of his focus and easily crossed over into every other issue the files holds.9
u/Sterlingsgma1I heard survivors talk about this place for a couple of years. About the underground levels. Complete OBGYN setup with operating room. Speaking of waking up while in stirrups. 😓💔😡🤬 There's ALWAYS been a reason they didn't search here. Just a conspiracy though huh?! Just as there was a reason this man🤬 purchased it at a discount. I'm in Texas and we DO NOT want him!!!8
u/BoredtopherThis guy couldn't even muster enough support for comptroller, hes not going to outcorrupt Ken Paxton now6
u/PsychedelicSarcasmYeah, he's openly advocating eating fetuses,6
u/Boopy7Okay -- some time ago, in the first admin when they were separating even infants and tots from moms, there was a lawyer who even had a three year old for a client, I kind of joked (but not anymore joking) about how they were rounding up families and getting hold of the kids for not only sex trafficking and indoctrination, which did actually happen, and infuriated me, but ALSO I said they were planning on harvesting spare body parts and getting blood (similar to Chinese concentration camps.) I was kind of kidding back then. Now? No. Thiel already gets hold of young blood to pump in and there are actual blood harvesting sites in India (I saved the long ago finds on this, somewhere on my computer) and I sort of kept an eye on whatever shit they were doing on longevity forums. Nothing wrong with synthetic or decent sourced stem cells, mind you. Or research into how to cure cancers. No. This is not my problem. My problem is I do not trust these people when they say they are "ethically sourced" bc NOTHING ABOUT THESE PEOPLE HAS EVER BEEN ETHICAL OR TRUSTOWORTHY. In Russia, Putin stays alive far longer than he might have bc of very shady surgeries and treatments, and Ukraine soldiers don't return if captured. This is happening here, while they steal from our country, and raid the coffers of others too. So of COURSE humans are part of what evil men feel they are entitled to raid, rape, and defile. If you look at a picture of this particular asshole who owns Zorro, he literally looks like he cut the face off a child and stapled it onto his own, like a demented elf. I recall seeing him and joking about that BEFORE I ever saw those masks, ironically enough.3
u/Lost_Equipment_3289His brother owns a large car dealership in fort worth/dallas tx area.  He had no opponent to run against so there was no losing. And he is someone every american and esp texan should heavily watch. He should not feel safe in Texas.3
u/QueefSeekingMissileEthically obtained baby hearts. Jesus Christ.2
u/This_Salt7080Im asking this just for clarity sake: is his company the ones involved in the research, or is it a company his company invested in? The wording of this makes it sound like Hest made a $1.8 milliom investment in secretome.1
u/FaerieKnotz"secret to me"1
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73r/DogfreeMonrovia bear euthanized after clawing at woman walking her doghuntress_m_thompson570%5267.9PRP knee treatment2026-03-18↗
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u/10IlIlIlI01She had cubs 😢 bet the mutt was aggressive towards the bear and yapping at it65
u/Few-Horror1984We are willing to put bears down because they’re “aggressive” but when a dog kills a human it’s not a given that it’ll be put down.38
u/Vibe2SummerThey took the cubs away from their mother, not surprising since these are the same people that take mutt offspring away and call themselves "parents" to feel good.30
u/SweeTetrodotoxin'twas a bear...acting wait for it a BEAR. a mother with young cubs and they chose the right of a dog walkers dog over the natural right of the Mother bear defending its cubs? I've been a silent observer of this sub for a while (before I started my account) This is fucking insane. Kill the mother snatch the cubs? And sorry Just that dog walks to walk their dog somewhere else, relocated nursing mother with cubs is a dumb and dangerous things for both mother and cubs. females don't defend territories like Male bears but have specifical well known home ranges.... This is insane.21
u/limesqueezyxA mother bear protecting her cubs, so sad! The dog was the aggressor wtf18
u/Dog_Free_AfternoonThis is insane. How much do you want to bet that the stupid dog was barking and/or antagonizing the Mama bear?14
u/potatoes_arrrr_lifeThe hypocrisy is so maddening. Bet her dog was off leash and threatening her cubs. Of course dog owners are out for blood. But when a dog bites someone, they call it a nip and pretend it didn't happen. They go mad when dogs that have attacked, mauled and killed get scheduled for BE. Why does a dog's life matter above all other living things?13
u/Good_Criticism_1680Justice for the bear I love bears this makes my heart hurt fuck dogs 😡😡😡12
u/madamechatonBears are endangered, mutts are an invasive species. Breaks my heart.12
u/Tom_Quixote_I'm willing to bet my house that the dog antagonised the bear and its two cubs.11
u/ToOpineIsFineOfficials say if you encounter a bear, stay calm and do not run. Instead, back away slowly and give the animal plenty of space. This is exactly what dogs hate to do. They are space invaders and won't leave wildlife alone.9
u/pmbpro”Instead, back away slowly and give the animal plenty of space.” Yeah, and I’m so sure that dumbass DOGS will also follow this to the letter too, along with their dog-nutter owners. 🙄😒9
u/bumblebeesandbowsAbsolutely infuriates me.6
u/ThrowitortossitIt was a mamma bear from the wild that had cubs and was just looking to defend them. There are pitbulls that get away with unprovoked attacks that tear children apart. That really sucks for the cubs.5
u/huntress_m_thompsonthis is from the monrovia city manager. the city council had lobbied to relocate the bear family. fish & game just went ahead & deleted the bear. monrovia city. it mentions the attack in june 2025. fish & game said it had too many attacks on humans. two, to be precise. why do we not follow this rule as enthusiastically with maulers?3
u/Specific_LifeA bear is allowed to defend itself. Dogs and humans shouldn’t take priority2
u/arachnilactose08I really despise this trend of tracking down and destroying wild animals for behaving like… wild animals. Usually in their OWN fucking habitats. Of course dog worshippers are going to capitalize off of this. One less beautiful wild creature because some asshole and their walking biohazard went into the forest —notorious home of bears— and was surprised to find one.2
u/Havingfun922Just a bear doing bear things. Nevermind, that line is only allowed for mutts2
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74r/AtlantaHere's What Happened This Week in the State House and State Senateznkatl800%3167.7stem cell therapy2026-03-08↗
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u/Atlanta_ManeSB 443 (Summers, R-Cordele) would increase the offense of obstructing streets, sidewalks, or highways (e.g. as part of a protest) from a misdemeanor to a high and aggravated misdemeanor. That won't be used to suppress protests at all. People jammed on a sidewalk could be arrested simply for standing packed like sardines.50
u/LastMuelLook at all that culture war bullshit.30
u/composer_7HB 1495, it's legitimately insane how all there's so many laws and programs the only benefit Boomers as if they're not the richest generation in this country. Regular people need these rent protections, among the other benefits these Boomers vote for themselves to enjoy.29
u/Radiant_Maize2315120 WHOLE hours? 🙄23
u/SavathunTechQuestion“Harbin, R-Tyrone) would allow gold and silver to be used as legal tender in the state. (Harbin, R-Tyrone) would require public schools to teach cursive handwriting by third grade” I shouldn’t be shocked these passed the full state senate but they’re both so dumb. I assume gold as legal tender is some “buy gold” culture war bs, and requiring cursive to be taught IMO is a waste of time as it isn’t required for anything anymore. Students would be better off with “learning to use the computer class” that teaches typing, file folder systems, etc as that’s actually becoming a real knowledge gap.19
u/harps86We are not sending our best.19
u/Louises_earsPossession is already a crime, doing so in the presence of a 13 year old doesn’t make it worse. We already have child endangerment laws, if that’s what is actually happening. Just seems like a way to add additional charges for no good reason.14
u/Commercial-Border227There’s no reason to increase rent on anyone of any demographic. Why should a person pay more for staying put than a new tenant? And should the landlord be able to increase rent by 25% on a 30 year old just because they’re younger? This is so wrong. Can’t afford to rent, can’t afford to buy!12
u/Loud_Fee7306Desperately need someone to confirm for me whether or not HB 1223 is what it sounds like. Because to me it sounds like they are attempting to declare that if a cop kills someone, they get to withhold the bodycam footage or audio from the public with the excuse of ″privacy interests″. Am I misreading? Am I Chicken Little-ing with the law here? Is this one of those things that′s already on the books anyway and they′re just changing the language around a bit? What is happening here?11
u/aumnrenSome of these are actually fire. 120 hours of pregnancy leave for state employees is great, sad it’s not for everyone else. The all included price tag is fantastic too. Tried of having to do the tax guessing game, even if I’m used to it.8
u/znkatl*If you want this delivered directly to your inbox, sign up for my free Substack at https://zachnikonovichkahn.substack.com/6
u/ATUGAJust read through the whole list… and didn’t really find much to be excited about. Usually it’s a little juicier…4
u/SofiNatural7Is the included tax price tag going to be statewide, and when is this implemented? All stores?1
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75r/covidlonghaulersIf money was no object what treatments would you try?Dazzling-Light-3487320%12067.6stem cell therapy2026-03-21↗
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u/LindenTeaJugIf money were no object I’d get a personal chef, a driver, a personal physical therapist, and a massage therapist to come to my home daily. I know those aren’t medicines but I react badly to meds and would love some daily help to see if it would help me heal!62
u/LifaceMoney is no object for me, but once you get to that point, it's not about money, it's about risk and effort. I entered a 60 day (and counting) bedbound crash from a fairly innocuous medication - low dose tirzepatide. You're not asking the right question here. The treatments you should try are not based on what someone with unlimited money would do, they are based on what fits your underlying test profile. I recommend getting comprehensive testing in order to guide your treatment options further.48
u/Kyliewoo123This question is asked all the time. I think what it’s really getting at is - what’s the magic treatment that most people don’t have access to because it’s too expensive (sorry if I’m wrong here). The reality is, “long covid syndrome” is just that. A syndrome. There are likely different issues going on for different subtypes of patients, and even within those subtypes people will respond to different treatments. LDN and LDA are commonly used medications that are fairly inexpensive. I think everyone should try each of these first. For lesser used treatments - I think if you have inflammatory factors at play, plasmapheresis followed by IVIG is likely the best treatment option. But I don’t see it curing anyone, just improving quality of life. Stem cell transplant sounds risky , and tbh I don’t know enough about it to make a comment. HBOT seems meh. SGBs help maybe 1/3 - 2/3 of patients with neuro symptoms. My true and realistic answer is - If money is no object, put it all towards hiring help so you can preserve your energy, properly pace and avoid PEM, and use any energy you may have towards something enjoyable instead of ADLs, chores, work (if possible… some like myself are too sick for that). Rest of the money goes to research. I personally donate to Open Medicine Foundation, PolyBio Research Foundation, and Dr. Jarred Younger’s lab at university of Alabama at Birmingham20
u/yellowpanda3Money is no object for me and haven’t found a total solution lol, but what helped the most was ivig and seeing a specialty doctor that operates outside insurance or any major hospital (who was able to get me ivig among other things)16
u/technician_902I would be be funding the research for diagnostics and treatments for long covid. No more having to guess what works.8
u/Impossible_Roof_JackNot aiming sky-high, but at-home HBOT. A 1.5-atmo soft unit runs $1800/month around here. A 2.0-atmosphere hardbody unit would be great to nap in. Ditto a 360* red light treatment bed. PEMF or trans-cranial magnetic stimulation. Don’t care if it’s off-label, the only limiting factor has been price. Acupuncture at least twice a week, basic IV treatments multiple times per week for generic brain fog, maybe trialling POTS treatments or recommendations for vascular dementia. Plasmapheresis or EEBO, possibly? My symptoms are almost all neuro now, so not sure if it’d make a dent. Diagnostically, finagling an fMRI may be nice. Just for fun, something like an Eight Sleep for cool overnight sleep.6
u/coconutoatsStem cell therapy. If money and pain/surgical anxiety were no object…6
u/CANfilmsI would put the best researchers on the planet, with the best equipment, and make it their sole purpose to find a cure for long covid6
u/Fearless_Fig_6568All of them. All of them5
u/Human-Committee3250Reincarnate 😍5
u/LeoKitCatDaratumumab, isatuximab, IVIG, and finally even a full stem cell transplant4
u/Choco_PawsI'm much better now so I don't want any more treatments but: When I was really bad, I didn't have an issue with money. I had an issue with my own capacity. When severe or very severe, you just can't buy yourself more energy to actually go get the treatments, the tests, etc. When you are stuck in bed in a dark room, there's only so much you can actually do... Some treatments or tests will just not come into your home, no matter how much money you throw at doctors. In my country, doctors are clueless and absolutely not willing to try experimental stuff. For example if I wanted to try SGB, I would have had to travel in another country. It was absolutely impossible in my state a year ago, I couldn't even sit up without crashing.4
u/Stranded_SnakeI would honestly do a blood transfusion or some type of blood cleanse if that’s the right word for it.3
u/Dazzling-Light-3487[deleted]2
u/MiserableInspector94Chromolyn sodium, Ketotifen. Natural mast cell stabilizers. All compounded antihistamines available on the market for my untreated MCAS. Treat my subclinical hypothyroidism. All compounded muscle relaxers for untreated severe muscle pain and CCI. Creatine, collagen. A taylor made Multivitamin without fillers and vitamins I react to. I would make my own infant/Nutritional formula so I am not emaciated anymore, gainweight and not lose wat muscle mass i have left. Medically supervised food introduction by allergist/Dietitian to up my 3 safe foods intake. Iron infusions, vitamin D sunbathing. Red light therapy. TENS machine / vibration plate. Full vitamin, nutrional panel and Elemental diet for SIBO.2
u/poignanttvI’d buy the Ammortal Chamber and Shiftwave chair for daily in-home use. With those two plus the Neuronic helmet, I’m fairly functional2
u/eefrIf money were no object, I would try every single safe, vaguely plausible therapy that exists. I'm six years in, as of today. I  would try basically anything.2
u/omegagaspI would love to try Maraviroc. It's so fucking expensive that I probably won't ever be able to and that sucks so much.  Also whatever my doctor wrote down as a treatment plan for me to try. I won't be able to do that unless I find a charity to kindly help cover the costs.  Other than that I'd move to a place that has an elevator and is generally more accessible, I'd get a driver, a cleaner, someone who cooks my meals and someone who helps me bathe regularly. If all of this would be taken care of, most sources of PEM would be gone and I'd have more chances of improving over time.2
u/East-Enthusiasm2504Car t Cell therapy2
u/ebaum55Id run every test imaginable that pertains. Gut zoomers, mycotoxin, every single blood marker possible, and other forms of testing I cant remember ATM. I feel this would and has provided so many answers to many people. Id upload all this data to multiple Ai platforms and use Ai to check other ais responses analyzing from a functional medicine perspective. This should get me very close to root cause(s) and a course of action. Depending on the answers most likely find the best functional provider i can find and compensate them to solve my particular case.2
u/kimchidijonIf money was no object I would be putting it towards long Covid research.2
u/danceintheflowersstem cell treatment seeing a medium or psychic having a safe home and not having to stress about become a climate migrant. or the weather causing flares and messing my days up. oh maybe a magic wand to fix climate crisis and expel the evil men starting wars, violence, etc.2
u/Useful-Secret4794I would summer at the coast like a consumptive Victorian. I would also try the HELP Apheresis protocol on Cyprus. If I’m going to be this sick, I wouldn’t mind a view of the ocean while I cope. Also, I’d get a personal assistant, as well as a housekeeper/cook. I can’t keep on top of appointments because every call takes so much out of me. I’d love to have someone who knows me well be able to man my calendar and make sure things don’t fall through the cracks. I’d crash less. Plus, a clean house and nourishing meals would go a long way.2
u/Excellent_Notice4047Someone is doing well with something called TruDose, I heard on FB. Might try that one1
u/curiouscuriousmtlTerzepetide, maybe some weirder peptides, maybe the weird thing where they remove something from all your blood (I can't remember what). I think just getting labs done a lot might show me what is going on if I compare it to how I am feeling at that time.1
u/brentonstrineDaily HBOT.1
u/caffeinehellDeep Brain Stimulation DBS for blank mind and anhedonia1
u/Sad-Abrocoma-8237Everything1
u/Evening_Public_8943I would try ivig and apharesis. Get my own hbot chamber. Hire a person for cleaning and grocery shopping. My meds currently: LDN, LDA, amifampridine. I will try rapamycin next probably1
u/BGM1988I would quit working and continue on my own pace without triggering pem cycles. Im slowly improving but think working slows my recovery. (Only work 2 days a week)1
u/Internal-Back1886for me/cfs stuff, RX Pros has NAD+ and peptide therapies that some people use for recovery. Dr. Patterson's RCCX theory folks tend to go with LDN first since its cheaper. stem cells are pricey but have the most anecdotal reports.1
u/apexnightmare333I would fly to Dubai , and ask for an inpatient treatment in the long covid clinic.1
u/srh-trzI would try every single treatment available !1
u/donotdiedragonflyIf money was no object, I would go to a functional doctor and try some of their treatments. I would also get a Pulsetto for vagus nerve stimulation. Probably a few other things I can think of. PEMF too.1
u/chubiraraMoving to a place with better conditions to my basic health needs. That would be my physical and mental therapy1
u/hoopitydGet tests until they figure out what strain I actually have. Make a custom mAb. mAbs seemed by far the best treatment in the beginning. Then "they" killed it to push vaccines. Now the mAbs only work if you are lucky and get the combo that matches your exact strain which they don't seem to test for. They just give you the general ones and use the failure to continue to say mAbs don't work.1
u/Historical_King333Buy a g*n and have texas roadhouse treatment. Im done.1
u/AfternoonFragrant617None. Nothing works1
u/Caster_of_spellsIVIG and MSC stem cells probably 💸1
u/Friendly_Boss_8725Plasma exchange and EBOO therapy1
u/Gimme-shelter-6_21What does the IVIG cost! Pemgarda was $9K1
u/happylightedFellow first waver. Fuck, and I can’t say this enough, this.1
u/OkEquipment3467Om thinking maybe IVIG1
u/Gardnersnake9Honestly, money being no object alone would be a huge benefit to my personal recovery, by giving me the security to simply rest without worrying about surviving financially or being a financial burden on my loved ones, in addition to a physical burden from my inability to fully help out arpund the house. The past 6 years have been a roller coaster of having to work to earn a living, crashing, going on short-term disability, recovering with rest and time off, returning to work, crashing again, losing my job due to attendance issues, being denied long-term disability, rinse and repeat. When I was able to take a full year off in 2022, living on my savings, and truly rest without the stress or energy demands of a job or having to find one, I actually recovered. Then I returned to work in January 2023, caught COVID two weeks into my new job, and began the se cycle all over again in March 2023.1
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u/ComplexologyI'd probably go for bruce patterson's work. https://www.covidlonghaulers.com/north-america/home
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76r/UARSnewEmpty Nose Syndrome Demystified - Part 1Master-Drama-4555320%11167.6PRP knee treatment2026-03-16↗
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u/Unhappy_Performer538Okayyyyyyy will never be getting that surgery!7
u/PhazzeNice, you should link the pubmed papers that go over ENS, specifically the very thorough Scheithauers paper which completely explains ENS scientifically and for effective surgical treatments (IMAP, Nasal Floor, Augmentation) there are quiet a few papers incase a desperate ENS patient sees this. I empathize with you regarding ENS being like a dial, people often think its like a binary system thing, 1 you have it and 0 you dont, when its actually a wider range and hence why the doctors / scientists use the ENS6Q which ranges from a total score of 0 to 30, and its only considered ENS when your score rises above 11 because a score less than 11 is considered "normal" side effects of turbinate surgery, specially in the dryness and crusting domains. The suffocation symptom which is the tell-tale symptom of ENS is the worst, and it gets very concerning when the fight/flight response is chronic due to the suffocation feeling which completely disables sleep and therefore you become suicidal. I have to emphasize how it literally disables sleep, its not that you fall asleep and the sleep is low quality, no, its that you CANNOT sleep at all, its not possible to fall asleep because your nervous system jerks you awake as soon as you feel drowsy to sleep, its a doom'ish feeling when you are exhausted and you cant sleep at all which very acutely exacerbates suicidal tendencies. Fortunately I have seen that a good number of cases that have exacerbated suffocation (hard to quantify since its so subjective) are usually cases in which a lot of volume has been removed from the turbinate and are usually candidates for implants which have shown to address the suffocation symptom significantly and has been shown to decrease or eliminate suicidal tendencies because they get their sleep back.6
u/ResidentPositive8458If people are on this forum contemplating turbinate reduction. Please re-read the OPs post. This ain’t a joke. It’s a nightmare, even if you get mild symptoms, never mind extreme symptoms. None of the new techniques protect you from ENS. Lots of ENTs will lie, they will reject and gaslight you after. Pharma and the medical system is a profiteering scam. Always go the natural healing route6
u/GrimbochEnts are destroying peoples life because of Turbinate reduction Operation at least they should tell me about the Emtpy nose Syndrom (Leere nase Syndrom, syndrome du nez vide) before the surgery . the op has destroyed so many lives ( Still not recognized)5
u/EchopineExtremely well written and accurate. It’s a literal horror movie if you’re tipped into a symptomatic state. Not worth the risk no matter how small. UARS is bad. ENS is life ruining. Both is incomprehensible. I agree it is the lack of sleep that kills people. I too was jolted awake for many weeks and I thought with absolute certainty I was going to die. Life is still hell and I live in fear of it getting worse everyday.4
u/Grimbochthis is hell4
u/xThrow-Me-Away-JosexWonderful post and so well written! Are there any similar risks one should be aware of with a septoplasty and spur removal? I see comments here about having it in writing that turbinates will not be touched - is that a thing? The ENT world is in large part in the Stone Age - barbaric, non root cause soft tissue procedures that people go into blind to the true consequences. Maybe a septoplasty and spur removal is an example of an exception, because fixing this issue can allow the turbinates to shrink naturally over the subsequent few months. Loved your comment of “your turbinates are enlarged for a reason, find that reason”.3
u/Hour_Hospital_9068I’m sorry for what you’ve been going through. I haven’t had turbinate reduction myself, but my kids (both under ten) had it done years ago when they were 3 and 5 during tonsil and adenoid removal for sleep-disordered breathing. I’ve already struggled with guilt over the tonsil removal, especially since it maybe helped but certainly didn’t cure their issues, but now I feel sick over the thought that the turbinate reductions could’ve damaged their nerves and/or set them up for other issues in the future. The ENT assured us he was conservative (radio frequency ablation, iirc), but what are the chances of this harming a child?3
u/idkagoodusernameeWow, what a post. I can’t even begin to express the empathy I feel you for. I’m scheduled for a turbinate reduction and deviated septum surgery in a few weeks. I developed severe heart failure after the Covid vaccine at 29 years old with an ejection fraction of 8%. They almost sent me home from the hospital because I was “young and healthy, and probably dehydrated stressed out and tired” so the “it’s safe, it’s so unlikely to happen” argument never works with me anymore. I’m so glad I read this, and I really hope to read more from you if you feel up to sharing it. Frankly I’m anxiously awaiting. Words cannot express how much I feel for what you’re experiencing. And thank you so much for sharing. I very much want free nasal airways, so bad. My sleep is starting to really hurt my life, desperately. But it sounds like comparing apples and dinosaurs compared to this. Ugh3
u/PjeseQSo if you're scheduled for FESS but decline any surgical intervention in your turbinates, you should be fine?2
u/Low_Task_7499I have been ising azelastine fluticasone nasal spray lately and it’s helped my sleep. But I am a bit worried now about further use since I have experienced dryness and other things since the turn reduction. I am curious, what do you think were the reasons as to why you developed ENS 8 years after surgery? Did it Get Worse gradually or just suddenly woke ut and had full blown ENS?2
u/Soft-Buy-6999is xlear an ok nasal spray for long term use?2
u/External-Scholar1567This is super well done. Thank you. I’ve had a septoplasty and turbinate reduction done several years ago. I don’t think I developed ENS, but I did just get surgery for Nasal Valve Collapse using the Dolan technique and tightening my nasal side wall. Could this cause ENS too? I’m worried now I’m not even 2 weeks post op. Also, ENT said to use nasal spray rinse. Should I stop that immediately?2
u/bros89Thanks for the write up. Is there anything that can be done to cope or heal?2
u/UARS-StinksThanks for letting other's know and to spare them. Waiting for part 2. BTW: I read about some clinics in Europe treating ENS with capsaicin. You might want to give it a try if you yet haven't.2
u/3wildflowers-5Wow I am so, so, sorry you have had to go through that. Are you doing better now? I hope so. Are nasal sprays and rinses dangerous also for people who have not had the turbinate surgery?2
u/External-Scholar1567Are there differences between radiofrquency, microdebrider, and physical removal for turbinate reduction as it relates to ENS?2
u/Realistic-Dog2630My doctor recently recommended turbinate reduction along with a septoplasty. I told him I did not want turbinate reduction. He secured with me to the point that I do not trust him. So neither procedure has been done.2
u/Mundane_Fig2810Thanks for the sharing, I read the whole thing, but with these questions: Do you think everyone who went through the turbinate reduction will develop ENS at some point post surgery? That sounds scary tbf. If not, what’s the percentage? Are there any warning signs? I had a severe deviated septum with allergic rhinitis since kid, these also resulted a severe swollen turbinate on my right side nose(it is almost completely blocked). 1.5 years ago I did the septoplasty with turbinate reduction specifically at a doctor in Germany who is conservative at it. He reduced it and other doctors say it is still a little swollen after the surgery. I felt really good and nothing weird on my nose ever since, I can finally breath through my right nose again. Should I be worried?1
u/samagreat12I am thinking of getting MARPE, I had spetoplasty and turbinate reduction in December 2024. I feel my left nostril is little bit more open and my right nostril gets congested when I lie down or try to sleep. Will I ever get ens if expand by 10mm? <image> I have attached my cbct which was taken 3 months after surgery.1
u/weird_well123Check the pinned post on r/uars. There's some other info at old.reddit.com/r/ensinfo.1
u/Realistic-Dog2630I’m just brain storming. I currently use an ASV machine. Would an ASV set to a high pressure support assist with breathing during sleep?1
u/Low_Task_7499Do you have any thoughts regarding bipap use and risks of developing ens?  I have had a turb reduction about 2 years ago. I am asking because I sometimes Get dryness if I open up my nose with Intake breathing strips, or even if I just mouthtape without the Intake strips. It seems like if I open up my nose or strictly breathing through the nose at night with the mouth taping that my nose starts to hurt and gets dry. Pondering whether the increased airflow from bipap would somehow damage my nose more, or that the remaining turbinates would not be able to handle it? I guess using the humidifying hose should help. I sort of have to try bipap tho because of the debilitating uars. I also remember feeling that my nose felt too open the first 2-3 months after the turn reduction, but then it went away. Only usually experienced dryness or nose pain if I try new things for the nose such as mouth taping or Intake strips or steroid sprays and such.1
u/PjeseQQuite a bit of comments on expansion being an alternative to soft tissue surgery. Unfortunately, if eg. your recesses are fully obstructed, then I learnt FESS is your only option. No expansion will fix this. Similar story for Haller cells - most of the time, they gotta be removed and that's it. Sucks to be born with faulty airways, I hope I will finally get rid of my REM-predominant shitshow.1
u/angelxdustx101Man I am so terrified of this. I had a septoplasty and turbinate reduction surgery done 3.5 years ago. Doctor only had the splints in for 2 days. I kept having issues with my right nostril swelling and blocking airflow so I had another in office reduction 6 months after the first. Worst fucking experience in my life. Now 3.5 years later I still can't sleep at night because the second I lay down my right nostril completely closes off. I have all this sinus pressure and mucus and I cant get any airflow thru! Only half of my nose works. I have another consult scheduled with a doctor in Las Vegas but IDK if she tells me I need SMR or more reductions done that I have the faith to do it.... But I cant keep living like this either!! Its every single day of my life I go thru this.1
u/turbosecchiaAny danger with azelastine sprays?1
u/United_Ad8618hey did you ever look into blood pressure medication in your journey of trying to tackle the turbinates? For example guanfacine or something like a α2-adrenergic agonist for adhd?1
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77r/physicaltherapyHow much value do you place on manual therapy?TheRoyalShire340%7366.8PRP knee treatment2026-03-12↗
commentercommentsentimentupvotes
u/XxHUNTINOxXGood for buy in and to set the stage for exercises.130
u/KingCahoot3627The deeper I get in my career, the less I use manual therapies. But PT is an art. You have to recognize when to use those silly patellar mobs. It might be once per day, once per month, or once per yr. The skill is digging in your toolbox to use your knowledge when its right for the patient59
u/tallpeoplefixerWhat i can't understand is why people get so polarized about others who do manual? As long as the cornerstone of your treatment is progressive overload and exercises who gives a shit if you do 10 minutes of manual first and it makes the patient feel better and gets you a ton of buy in. Nobody who comes to see you with 8/10 low back pain wants to jump into barbell deadlifts despite what you evidence based crazy people think.53
u/PleadInsanityManual therapy is well used for certain conditions, several CPGs have strongly supported the use of manual therapy and given A level evidence towards it for conditions like hip OA/ plantar fasciitis I think it's out of date to think that manual therapy has no business to be in the treatment plan as long as you're doing manual therapy and there's etc.47
u/angelerulastielI believe strongly in manual work. It absolutely will not solve the problem by itself, but I see it as a boost. It helps reduce pain and gain ROM. It helps with patient buy in and builds a relationship. And simple human connection is therapeutic. Trying to treat patients with exercise only is like building a house with only nails. There’s a reason we have different tools. Edited to add the ending that apparently disappeared when I posted.45
u/HammerLite75I’d prefer manual as opposed to almost any modality. Manual then exercise will almost always go better than just exercise. Plenty of patients don’t require manual. I really enjoy providing that service, provided the patient needs it or benefits from it. I do work in private practice so buy in important. I believe that it facilitates trust and a level of care that these patients do not get from other practitioners. It’s been around for much longer than other treatments as well. I don’t think you should be doing more than a unit for almost any diagnosis tho, aside from a B/L or multi joint diagnosis/patient.13
u/Lost-Copy867It depends. For example there are numerous studies linking loss of terminal knee extension to poor outcomes. So if I’m addressing this problem then some manual therapy (extension mobs) is going to be a part of that but I am also going to stress to my pt that performing their HEP to improve extension is the most important thing. Also- if I do any manual I’m going to test and retest every time. I have been an outpatient PT for 12 years and have taken a lot of NAIOMT classes and my overall view of manual is pretty neutral. It has a place but if you are going to use it you should be able defend why you are using it.11
u/drumstixclixPlacebo has a well studied positive effect- therapy is an art! We all know manual in isolation ain't doin sheeit. In combination with adequately dosed ther ex/ther act? Not harmful at worst, and makes the Pt feel good and creates buy in at best. Its a tool in my tool box that I don't discount solely on lack of strong evidence. Totally hear your frustration though, I hate doing it bc in my mind ik the mob/manual alone is barely gonna move the needle in terms of recovery, but I try and remind myself its an act of care and love. Just some OT thoughts11
u/Sugar_on_the_rumpusI actually find a lot of my knee OA patients like joint mobs for pain relief. I'll usually start with them for a few minutes then we get to active exercise.10
u/TheRoyalShire[deleted]9
u/lalas1987Sometimes manual is just a method of gaining someone’s trust. Sometimes manual can have an immediate effect on pain levels and that alone will allow the patient to do a thing or two they wouldn’t or couldn’t do before walking in the door. That’s a win. One of the problems with the art of PT is it’s very hard to study, hard to reproduce, and hard to develop really sound research around the manual/psychological/movement combo that a good session might entail. I keep manual in my back pocket and bring it out when it’s the right time. And that’s not for every person. But to say what we do with our hands is not ever effective I have found to be untrue. With that said I haven’t touched an ultrasound wand in 12 years. Taping I do rarely and cupping I suppose the most often.7
u/AlexADPTIt’s whatever The issue is with the charlatan quacks who say dumb shit like how they’re putting joints into place, releasing fascia, breaking up scar tissue, re-aligning someone’s natural chi with their pelvic shotgun maneuver, and the list goes on and on7
u/Spec-TreI use manual to get an idea for irritation around the joint/trx area based on muscle tone, ROM, reported pain, tenderness etc while also building rapport with the patient and figuring out where/when/how activities are still symptomatic. It has value to further guide my treatment and can make the pt feel better so they can tolerate the therex/act I have planned for the session. If it doesn’t happen in a session that’s cool too. I’m not doing manual bc my told me to6
u/jmrdpt19I will use it if my go-to exercises modifications/self mobilizations don't change the pain. I never go into the mumbo jumbo lingo with patients, but sometimes a little anterior tibial glide calms the system down enough that they can get back to exercise.6
u/rj_musicsIt has its place depends on what you’re trying to accomplish.5
u/NeighborhoodBest2944Of course some patients don’t REALLY need at all. But of you aren’t seeing a benefit to patients, you aren’t don’t it right. And that usually comes down to USING the new mobility/range immediately after and giving a home exercise that directly works on that.5
u/Royal-Government3488I often receive patients who transferred from other clinics because they felt the therapist never actually worked with them hands on. In reality, many patients simply want to feel that their therapist cares. They value that human connection and physical interaction. I do not mind spending eight minutes performing manual therapy. It helps me build relationship with my patients and, psychologically, it reinforces their sense that they are being cared for and supported during their treatment. Of course exercise is the best thing you can absolutely do for the patient. That has been scientifically proven. However, patients are humans that want to feel cared for. Nothing more. Nothing less.5
u/Binc42The effects of manual therapy span far beyond just the physical. Are we doing exactly what we think we are when doing mobs, STM, etc? Most likely not. But doing manual helps build rapport, build buy-in, get a feel for the joints/soft tissue in the affected area, and learn things about the patient to help guide sessions. For example, during manual I learned a patient misses gardening but felt “they couldn’t do it anymore”. So our treatment for the next couple of weeks focused on that. And they were so happy to be back to gardening. I’m also a firm believer in the more different stimuli that can be introduced to affected tissue, the higher chance to decrease sensitivity and subsequently onset of pain. Manual therapy should be less than 25% of the session though to prevent reliance or false perception of “the magic hands of the PT”4
u/45SocksToLaunderI like using it for some patients. It helps build the relationship, meet expectations, and can really alleviate some pain. I am biased towards an exercise approach, but I do think we don’t criticize exercise as much as we criticize other forms of treatment. Exercise is also not always so much better than other more passive treatments, which is frustrating, but a reality. I do think we provide a lot of benefit to our patients, but what types of treatments we choose…I think matters less than I would hope. I’m trying to be more of an optimist rather than a nihilist, but it’s hard when you start digging through the literature and find out how little we know. (Greg Lehman terms and influence here).4
u/buchwaldjcI teach continuing education courses on manual therapy to both physical therapists and massage therapists and also teach the soft tissue mobilization lab at our local physical therapy program. With most diagnoses, it doesn't make much sense to make a blanket statement that manual therapy is good for any specific diagnosis. Instead, it depends on what the specific deficits are within that diagnosis. If you take knee OA for example, if range of motion is an issue then manual therapy might be of some benefit. It might also have some benefit in pain reduction and reducing muscle inhibition. In contrast, if the major deficits are gait and balance, manual therapy might not be appropriate. It has a time and place as any treatment. And there is plenty of research out there on it looking at comparing manual therapy plus exercise against just exercise alone and finding an added benefit with manual therapy with certain dysfunctions.4
u/BigGambinoSosaSo would you say therex is the way to go?3
u/Far-Finger8964I feel you on the losing trust part and feeling like we go through alot trends especially with manual therapy. This is one of the reasons that I haven’t spent a lot of time or money getting certified in any particular manual technique. I’m still a very hands on therapist, but I mostly focus on soft tissue to help alleviate symptoms because I find that leads to better patient buy in. If my patient leaves a session in less pain than when they walked in then they’re more likely to be compliant and be an active participant in their PT.3
u/idkshit69420As a COMT I do a lot of manual. I do take ROM before and after but I'm doing ONE technique then reassignment. No I do not do manual on everyone. Yes EVERYONE does exercise. For knee OA specifically, in the COMT program we were to read articles that actually show there was no difference in recovery if we did or did not do manuals for that population.3
u/oscarwillisShould t be about how much value YOU (therapist) puts in manual therapy, but what the patient values. Yes, you need to educate. But a patient not coming back because you don’t meet them where they are…. No bueno for everyone. Shared decision making goes a long way.3
u/BoomerSkunkIt’s another arrow in my quiver.2
u/ReFreshingDepends on what you're doing and what for. For example knee mobs and assisted flex/ex stretch after TKR definitely helps. STM to get rid of perceived "knots"? Not so much. Yes a lot of what we learn turns out to be ineffective but through experience you should pick and choose what you believe best benefits the patient. If you don't believe manual helps in certain cases you shouldn't feel compelled to do it. Now when it comes to using it for buy in, placebo, improving behavior compliance.... Then that's another set of reason for using it and it has positive effects outside of the biophysical model. It definitely has its place in the psychosomatic realm. Just gotta know when to use it for each patient.... It's an art like many have said.2
u/Queen-of-Wands-13I'm a lurking SLP here. Manual therapy was super super effective for me and my tension issues. I do a lot of oral motor and feeding therapy and manual therapy changed the way I could move my tongue even after years of self therapizing. I also work with a lot of babies who receive PT and the manual therapy I am trained in is really helpful for a lot of them (they are generally seeing me for feeding issues but end up at PT first). These babies make progress in both feeding and reduction in tension/torticollis and usually increase in ROM in neck that they have not made with just traditional PT. Obviously I have a small sample size but I see a lot of anti manual therapy thought on here, and it's super helpful for a lot of my patients and myself!2
u/OddScarcity9455Modulating pain, getting buy in and patient expectations are like 75% of outcome. So yes it matters a lot for a lot of patients. (Number is not based on research, don’t come at me)2
u/Extension-Bicycle-54Someone clearly hasn’t seen the karate kid and Mr. Miyagi’s miracle hands2
u/fauxnessNot gonna lie I have a lot of patients leave other PT places because they did no manual whatsoever. They come to me, I do some manual (nothing fancy) and they feel better. Why? Idk but I’ll put my hands on a patient for 8 min if it means they get better. There wouldn’t be a whole profession dedicated to massage if people didn’t think it helped.2
u/capmapdapMy tiny hands can’t do much for obese patients as I can hardly palpate any anatomical landmarks and/or move a limb. A lot of patients now are obese. So no, not doing manual.2
u/deadassynwaVery little but it has its place1
u/climbingandhikingDoeneds on how much my patient values it tbh1
u/finks_finksIt depends on the patient. Some will benefit from it, whether for improving ROM or pain modulation or just building rapport. If a patient wouldn’t benefit from it or doesn’t seem to care for it, I won’t do it. If most of your patients are improving and coming back to you, then you’re fine without it. If patients are not improving or plateauing or canceling, then it’s something to try. Just another tool in the toolbox. Use your clinical judgement.1
u/Big-Count-3329Im a new PTA, but for me personally i like to start off with more manual therapy during the first few visits, however after like 2 weeks max i only save heavy manual sessions for flare ups.1
u/MossyBubbleAs an LMT and CPT who has almost exclusively worked in PT and chiro settings to do manual therapy and teach therapeutic exercises (also working on corrective exercise specialization and potentially going back to school to further my education into DPT) this thread is devastating. Are we not inhibiting overactive musculature to help reduce neural drive and increase activation ability/room for movement in the opposing under active muscle? Are we not using the relaxation effects of manual therapy to ease the client/patient when they’re scared and in pain? Do mobilizations of joints and soft tissue not help increase range of motion? I’m confused. In practice I’ve found that using manual therapy techniques really helps people live with more mobility and less pain - even before the implementation of stabilizing and strengthening movements. Isn’t that the goal? To help people live better in their bodies? Patients/clients love it and loving treatment creates the adherence to it which helps in the long run. Why leave out a good chunk of the equation? I’m serious I truly don’t understand.1
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u/browdoggI love the discussions of previous cases and uses of techniques in this thread. Is there a subreddit where we can discuss pt stuff without endless bitching about the profession? I’d love that-1
u/Dewey_PTProgressive resistance exercise and education trumps all manual therapy. I have taken every manual class under the sun and also gone through a manual therapy/orthopedic residency…it’s useful but only if it helps get the patient off the table quickly and onto progressive resistance exercise.-5
u/VO2VCO2Almost no value at all. Same goes for dry needling & other gadgets. It's very important that we use methods that are proven to be effective in randomized controlled trials. It sounds boring, but honestly, that's the way it is. If doctors don't see physical therapy as evidence based practice, they'll stop using us.-14
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78r/MorimensVortice Early Theorycraft Breakdown/DiscussionGyRNi650%2966.6regenerative medicine2026-03-06↗
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u/monchersDamn all these pre release reviews are crazy high effort. I will wait until she is released lol.10
u/LieLikeVortigern_Even if it's still soon to tell how she will work, I enjoyed reading this. Well done!4
u/thebizcuitI wish Dora was this interesting :( he came like 2 updates too soon ig3
u/ZeitzbachCorpo / Vortice / Murphy / Gmurphy is what I'm looking to play her with. My Lemurian side just use borrowed whale Gmurphy anyway for an A5 team so my OE Gmurphy is available to join this. Her ramp playstyle heavily support 6-turns battle. You OE Gmurphy on turn 1 to ramp up and generate tentacle while stalling with Corpo and Murphy shield and sacrifice removal that also ramp up the tentacle damage. Since she scales off Realm Mastery, you can just use the Nautila wheel and you're pretty much guaranteed a good amount of shield and can throw in White Stance Waltz if needed. Rouse Gmurphy and Vortices to ramp the damage side. 5 turns is more than enough to build up a lot of stuff with how fast you can cycle through the deck with Gmurphy+murphy Arith recovery and card draw into a discard if necessary to play more stuff. Then trigger a DR to fill up any missing Aliemus for a final Corpo Exalt or OE (since you're going to be expected to use her exalt to cycle deck) and on turn 6 you just go all in with all the exalt to do a big nuke into Sacrifice. The enemy chance of surviving a sacrifice stack is very slim or they will be so close to death the 2nd tick will kill them anyway. I might build a Returnal Line covenant if this works great in A5 so Vortice won't have to use the Deus one I built for Karen. All the extra tentacle hit is needed here with some wheels like Murphy wanting more hits to get as much Aliemus to reach the 5-exalt usage for Pursuit bonus.2
u/ReizeiMakoIt’s very helpful. Thank a lot!1
u/Cross_TossShe might be the first real Returnal Line user due to her stacking of Realm Mastery. 2-3 Stacks of Tentacle Gathering every turn potentially adds up long term especially as you ramp TDMG. No Gathering in Divine Realm1
u/Cross_TossBone-Chilling Embrace: Sanga's Posse provides +1 Tentacle Gen, Arith and some Delayed Shield. One of the few ways to generate Tentacles outside of Aequor units. It's either, not and1
u/Cross_TossSanga: White stance in Divine is a very easy way to generate massive shields for OE nuke cycles, but there is some antisynergy with eating Tentacles. Has TDMG stacking via Soulflare. Also Rouse, and can generate tentacles with her 4-cost, though it's extremely expensive.1
u/LinaseraHad a great time reading this. I'm so excited for her.1
u/Upstairs-Escape5778I was reading this and was surprised that base Murphy is not mentioned. Once Murphy is roused, she generates a temporary tentacle per murphy card played. Would that not help in Vortice ult? Or is there a specific caveat here which I've overlooked? Regardless, this was a very enlightening read. NGL, as cool as Vortice is, this one might be a skip for me. Fully F2P so lacking funds rn trying for E1 Horla, then Arachne after. I might consider picking her up on rerun though. RM scaling divine seems to be a cool novelty.
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79r/scienceRETRACTED: Prevention of acute myocardial infarction induced heart failure by in...shiruken1850%766.5induced pluripotent stem cells2026-04-01↗
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u/SaltZookeepergame691I’d love to be surprised but… well. I’ll add that the retraction note doesn’t even cover some of the most serious initial issues, doesn’t address that the BMJ seemingly didn’t bother to check registration details on the trial register, and also during peer-review failed to send the paper back to the most critical reviewer. Baffling all round from a supposedly rigorous journal.neutral67
u/Dr_Doctor_DocGet 'em! Science & Rigor > Ambition and Famepositive13
u/toughtacosFreakonomics Radio has a series about academic fraud that I really recommend listening to. It goes into depth about exactly this kind of thing. Very interesting listen.positive1
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80r/AgingTook a spill and got banged up. Feeling really old now. Other older guys (or lad...SurgStriker250%11066.5PRP knee treatment2026-03-05↗
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u/pb-snick1You guys aren’t that old, seriously64
u/Prestigious_Rip_289I am 44, very perimenopausal, and every time I have fallen in recent years has been in context of contact sports. I don't think we are at "aging related falling" age yet in most cases.35
u/Acrobatic_Ad7061Not an age related fall if you’re 44.18
u/Person7751i am 65 and have fallen twice this winter once because of my dog and the other ice. i got some scratches but nothing serious. over 40 years of weight lifting have kept my bones strong.17
u/fivebynine5x9I'm a bit older than you and can't say that's happened to me. Mid forties isn't really an age where you'd reasonably expect to start having devastating falls. It really just seems more like bad luck since people can fall and get banged up at any age. I think it would be helpful not to frame this as an old age fall. If anything besides just bad luck, it sounds more like the consequences of being out of shape/low T. Heal up soon though!10
u/Confident_Banana_13444? You’re so young. You need to snap out of it.7
u/Choice-Newspaper3603That’s a lot of goddamn words to say you fell down5
u/ScroogeMcBookBrother, I'm turning 43 this summer & last year I went on a Slip & Slide for the first time in 30+ years. The crushing weight of my 42-yr-old body, landing suddenly on my chest, bruised a few ribs & took about 2 months of daily pain before I could fully heal. A Slip & Slide.5
u/ExcuseApprehensive6872 yo male- very aware that falls at my age can mean other issue( medicare checkups ask “ have you fallen”) Anyway I’m a advid bike rider ( get around 80 miles week in season) and got distracted by something on road - road off road and crashed into a corn field. Landed before corn but totally unhurt- scared the crap outta me. Wife & myself walk / hike a lot. Always looking at our feet ( especially mtn hikes) tooo easy to sprain a ankle or twist a knee.4
u/Effective-Motor3455I’m 63 I had several falls this year. On Xmas day I broke my hip. Thankfully during PT we found why I was falling, it’s a vestibular system issue w my inner ear and eyes. I’m going to be getting help w that now so hopefully no more falls.4
u/Infinite_Violinist_4This is not an age-related bad fall. You listed all sorts of reasons why you fell. I pick flip flops, uneven walkway and not paying attention as top three reasons. If you were 70, you would know all the fall risk around you and pay attention. At 44, this is hardly age related. Sounds more careless. My husband is 75. He currently is recovering from a broken ankle after stepping on the only patch of ice in our driveway and falling. That I would call an age related fall.4
u/soulselfIm 43. 3 weeks ago, my foot fell asleep while I was sitting, working on my laptop. I stood up and tried to take a step and my foot didnt extend. I felt my foot/ankle crack 3 times and I hit the floor hard. I now have an ankle fracture and crutches for the next 5 weeks minimum. That was not on my aging bingo card.4
u/LadyArcher2017[deleted]3
u/K21markelI’m 73 and haven’t fallen so why don’t you chalk that up to being clumsy not old age!3
u/plantverdantYou aren't old enough to have had an age related fall. I'm 46 and I have never stopped falling down since I learned how to stand. What you experienced was a health related fall. You should do physical therapy and fix your balance issues. I fall much less than I used to by improving my core strength.3
u/Spare_Objective969744!?! Bruh. Your body is what your mind thinks it is. 44 is young. Stop telling your body it’s old.3
u/xeroxchickYes. Stepped into the stirrup and this young horse just went ballistic and I came off. I used to dust myself off, but this time I broke two ribs. Missing that estrogen. That was ten years ago. Edited to say, I was 53 then.3
u/Beautiful-Low9454Oh yess a few years ago (48 years old then) I got hurt very very bad. Bought my son a drone for Christmas and I was flying it inside the house. The central heat kicked on and started to blow the drone towards my GF. It was about to hit her and I jumped up to try to catch it. I missed, fell on the floor and broke my tibia AND fibula on my left leg. Had to get an ambulance to come and get me. Broke it on December 28 and couldn’t get surgery until Jan 1. On my way to surgery and a bad thunderstorm hit knocking out the power to the entire hospital. Then taking so many pain killers I stopped going #2. Had to go back to hospital to go #2 again. Had to have an enema. Needless to say it was very very bad. Smelled awful. Pushed the little porta potty out in the hallway. 2 poor women were passing by and got absolutely sick at the sight and smell. Hell of a time … so yeah I’m way more careful. My leg is still messed up and I’m in pain every day. That was 7 years ago and still I hurt every single day3
u/kpooo762 have not fallen last couple of years except taking a dive in Pickleball, need to do core and leg workouts until you die!2
u/No-Reading-4384I’m 70 and 2 years ago started to get vertigo. That WILL make you fall2
u/GutRasiertI have MS so it's a bit easier to fall. What I do to protect myself is to build muscle. It helps prevent falls and when you do fall, the muscle is like a protective barrier. We all get weak as we get older. One day if you don't maintain enough muscle in your arms, you won't be strong enough to prevent your face hitting the pavement. Take this as a wake up message and get strong and stay strong2
u/Infamous_Ad8730Ha! Mid 60's here and still riding my dirtbike fast as heck, so YES.2
u/sportgeekz77m. Tripped on a length of angle iron helping neighbor move her chicken coop. Hadn't fallen since learning to ice skate at 61.2
u/dogfitmadYea dude at my gym we have 70 year Olds jumping into boxes and doing burpees. I think you need to get to a gym. It will help with everything. Bone mineral density. Reactions. Maintaining lean muscle mass. If you are feeling like this now imagine in five years..this was shocking to me to read your age. Honestly going to the gym is an investment in your future and longevity of independence. Not walking. Not sitting on a static bike. Weightlifting. Intervals. Bad back,knees etc? Strength training is a necessary for pretty much every issue. Backs need loading. Tendons need loading. Joints need strong muscles around them and good blood flow. People bag Crossfit out but the things I've seen and the transformations in people are actually unbelievable. Not in looks though that is good too I mean in quality of life. Everything can be scaled or changed but anything is better than nothing. Training is like work. We might not want to do it but bro we HAVE to.2
u/ragazza68I haven’t fallen yet but my husband (over 60) has had 2 minor falls - no injuries. He started taking balance classes at the Y which seem to help2
u/ttnezzThat isn’t age related! I’ve been falling in similar situations since I was born and it always hurts. You probably bruised a rib or tore intercostal muscles. The ribs take a bit to feel better you could try and tape them. I’m in my 40s as well and I am not falling more but what I have noticed is that I strain things more easily doing simple things like turning my head to look at something. I’m more cautious when I move now.2
u/PrestigiousJob494Getting pummeled on the market today but you gave me one hell of a belly laugh. 44 ain't old, mate. Long may you live.2
u/Vanhosen77You're 44. You would have to be in awful shape to have an age related fall at 44? You're age played no role in your fall. Join a gym and eat better.2
u/JheritheexoticdancerForty-four? Heck, you’re still a youngster yet. 😉🌸. I live in a major metro area, have two left feet and between ages 20s-40s I fell a lot tripping on cracked, uneven pavements and twigs. Both my knees are now shot and I was told I have arthritis behind both kneecaps and would never be a candidate for knee replacements. I was so glad when I was told that because I do not like the idea of surgery, but others have suggested that I should get a second opinion. But I do what was initially medically suggested, keep moving, so when I’m outside on concrete I always look down when taking steps and/or walking. I went through a period when I got gel shots in the knees and prednisone in the back. For me the gel for the knees and prednisone for the back didn’t work. Now when Arthur screams at me, I use knee braces or sleeves to stabilize them for a few days and I keep it moving. I am 70+.2
u/Embarrassed_Wrap8421The first time I fell was in NYC and I slipped on a patch of black ice and fell. A nice old man who was leaning on a walker came over and helped me up. The second time was at my house, taking out the garbage, and again it was black ice. I don’t feel old but I’m not going to push my luck. The worst part was not falling—it was being unable to get up as quickly as I did in the past.2
u/Glittering-Poetry-88I'm 46 but right before I turned 40 I jump off a wall. It felt like my knees almost shattered. Never jump off another wall since that day. Slowly we learn. 😆2
u/EshabelleThe day after xmas 2025, I (66F) was walking a friend's golden retriever. We both saw the squirrel at the same time, only I forgot to let go of the lead until I was already airborne, like Buzz Lightyear. Splatt on the sidewalk. Bruised chesticles. 2 fractured ribs. It's still a bit ouchie when I yawn or have a good stretch. And really, I'm not sure that's age related, but it felt that way to me.2
u/rapovandanI was 42 and took a nasty spill while on my mountain bike. I hit a tree root and couldn't react in time. Fractured my skull, broke a collarbone, sprained an ankle, broke both a wrist and elbow on one arm, and nearly broke my neck. That was 22 years ago and I still have trouble from that crash. The collarbone didn't heal properly and my neck bothers me to this day. That's a mistake I wish I could have a do-over.2
u/Calm-Age-1784I’m 62 and thankfully I can’t remember a darn thing!😂🤷🏻‍♂️2
u/geth196263 m. I did what I always do, and vaulted over a wall. My hands slipped and I hit the floor from about 4 feet high. That was about August last year, and my shoulder is still hurting. My left forearm was one big bruise that lasted for two weeks, and my left hip was so sore, I could barely sit down.1
u/makeitmake_senseMy dad at that age has fallen on ice so many times ice fishing and coaching ice hockey and never broke a bone. You’re good. Brush it off, you’ll get better. Your bones are still bouncey.1
u/PhillykratomIm 44 as well and have my first major injury in my life. My shoulder hurts constantly and ahav3 an appointment next month to repair. Core strength and legs are super important the older we get. Flexibility is probably.the most.overlooked thing as far as staying fit after 401
u/mjh8212I can remember being a kid and my knee buckling and I was able to stop myself from falling. At 41 I became a fall risk it was like my knee didn’t want to hold me up and I was 275 pounds my patella didn’t even look like it was in the right place. I’m down to 160 still falling. I learned two months ago at 47 years old I’ve been hyper mobile my whole life. Now I have subluxations in my hip as well as my knee. Down I go. I use a rollator for balance. Also two months ago I started showing signs of pots. I passed out and banged my left knee in the same spot twice in two days and have a wicked bruise life is fun for me right now1
u/fartaround4477I started falling after being put on BP meds. BP gets too low which ruins balance. I reduced the dose of beta blockers and walk more carefully now so no more falls I(for now). If your T is low try Maca herb which is energizing. Avoid dairy which can be contaminated by estrogens if cows are given bovine growth hormone.1
u/GinsdellOh yeah. 58 In the bathroom, naked, screaming and crying at the same time. Took a month to recover. I’ve never been the same. I couldn’t trust the tile floor or the shower for at least 6 months. I’m still stupid careful.1
u/Red-is-suspiciousI’m 45F and my husband is 50. No falls like that. I star My husband was also bed bound in hospital for two months in Nov and Dec and he’s back to feeling pretty good physically with his PT and doing all activities. You need to have an exercise routine that also focuses on balance and strength. This isn’t age related so much as it’s sedentary related and maybe some uncoordination/balance issues that could use neuromuscular retraining type techniques. Did you know that simply exercising and lifting weights can bring your T up naturally? Also there’s ways to get T that aren’t through insurance and can be actually cheaper.  Like I mentioned I’m 45 and a woman so I have naturally low T but I did add in 10 mg a wk as I started a very physical job at Home Depot and I’m keeping up very well with just a little extra nutritional support. I’m lifting cement and mulch bags regularly and going up and down ladders. And there are MANY older men working their butts off there as well - 60s and 70s men regularly step in to help me grab pavers and carry bales of straw or 2-3 bags of mulch to my 1 bag. This is just their retirement gig they do a few times a week too!  My mom is 75 and walks 15 miles a week and does all sorts of isometric stuff and HIIT and Plyometric type things and she’s quite stable and steady. Be active and make fitness your priority and I think you’ll have a new song to sing.1
u/boho_magpieI went roller skating with my kids in my thirties (birthday party). Here I am thinking it’s like riding a bike and since I used to skate in junior high all the time, it’d be fine. Don’t do it. It is NOT like riding a bike. Pretty sure I broke my coccyx. Definitely had a hard time sitting upright for about a month.1
u/tickled_your_pickleAlmost 44, tripped over my own feet Saturday, crossing a street.  I skinned my palms and cut my knee but mostly I was super embarrassed (so much traffic and it was in front of a packed McDonalds). My mom hit 70 and started to decline: tripped over her own flip-flops and broke her wrist/slammed her face into a counter, broke her hip going down stairs (fortunately she lives in an apartment building so someone found her fairly quickly), plus dementia.  I'd say were not doing bad with our scrapes and pulls1
u/BKowalewskiLast time was almost 20 yrs ago when I slipped on ice and chipped my elbow.. nothing so bad since and I'm 74. I seriously never fall1
u/RealtorRVACityI am glad you brought this up as I had a super hard fall last Friday, legs went right out from under me and didn't have anything to grab onto. Cowboy boots and wet tile are not my friend. Landed butt first, skinned on knee, and have been sore ever since. I went down HARD but a week? Sheesh, this sucks. I am just glad that I didn't break my tailbone which I did during the Covid lockdowns and that took 2 years or more to heal. Yikes.1
u/TrainingLow9079Around 45. I wasn't injured but felt lucky not to be.1
u/TigerbatonYou are 44, this wasn’t an age related fall, it was a trip after a bad step. Kids trip, teenagers trip, adults trip. Sheesh!1
u/CheesyTotI do the funny slow walk when I walk in wet areas, cause I don’t want the fall1
u/TetonHikerFalling in your 40's due to age? Kind of early for that kind of thing. I'm 75(F) and have had zero falls so far. My 78(M) hubby has started to have a few due to some balance issues but it just started around age 76. Maybe you need to take stock of your physical fitness and make some changes. It's early to be falling due to age. I mean accidents happen and anyone can fall at any age but if you think your condition is getting worse, then you might want to get checked out medically first and then hit the gym if you need some strengthening. Do it now before 50-75.1
u/rather_be_gamingYep! I remember twisting ankle after falling off a ladder. Not even high up ladder. Anyways, ankle hurt like a mofo. Went to see doc and she said its not broken. I said so it will be better in a couple weeks? And she let out a big hearty laugh. She said a month or 2. I wasn't 20 anymore. That humbled me.1
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
81r/GracerobloxCraven but as a dw toon.foxyfan37_1987680%2666.4regenerative medicine2026-03-24↗
commentercommentsentimentupvotes
u/Available_Mud_911WHAT IS THIS8
u/manfacewizardso is rue related to craven or something in this or like (i like the idea of grace entities in dandy's world for some reason)7
u/om0ri_here's my take on this kit, with an updated description! Craven the Raven Description "Craven is a brave doctor, who can protect anyone from danger!" ...At least that's what he wants you to think. His true self is that of a paranoid coward, but he almost never shows that side of himself. He's always eating too much, and sometimes steals food, but you'll forgive him, right? Abilities Malicious Medicine (Passive) Whenever Craven is buffed, the effect of the buff is doubled, but Craven gains Tired III for 3s after. (edit: removed the second ability)5
u/sillyguylulzfire3
u/Slight-Real001woowowowowowow it's craven3
u/AmongUsSigmasiIs this a creating site of some sort except the art?3
u/ThunderLP15they adding anyone to gardenview these days. Also implies Slight is here, as well a form of addictive substance that Craven fell into (ichor mayhaps)3
u/JoyousLilBoyWill there be other grace toon drawings2
u/Aggravating_Run6179Cool!2
u/Primary-Base-7662GIVE ME KOOKOO and FOOL AND YOU HAVE MY SOUL2
u/Ok_Juice7052I thought Twisted Craven will be like When it snapped (beheaded)2
u/toast-the_gooberok2
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82r/tresslessReducing Fibrosis in Hair Loss: Topical Pirfenidonenoeyys530%3666.4stem cell therapy2026-03-26↗
commentercommentsentimentupvotes
u/Lev1nnHi, i cant use minoxidil foam or topical on my head due to seborreic and Malassezia. My dermatologist said your hair loss is not AGA im thinking my hairloss is due to dermatit and malassezia want to ask you think that gel gonna help to recover my scalp?3
u/HelpingmehelpNice work. Very interesting.2
u/Zealousideal_Sun6495Very interesting. What are your thoughts on copper peptides to support scalp health and possibly hair growth? (As an adjunct to fin/min ofcourse)2
u/Ralphiedog11Any way of getting this in the US?1
u/Luke10191Great content as always. Can you make a video regarding how a female should deal with androgenetic alopecia?1
u/AlakagomIs there any merit in introducing anti-inflammatory products without obvious inflammation in the scalp itself? Might not be visible but still affecting the hair and the stem cells in some way? You mentioned Wnt/B-catenin modulators which we know has a role in hair growth regardless. To me it sounds like Pirfenidone might play a role in a Dutasteride/Minoxidil stack through its mechanistic process. Hair loss is clearly not just a DHT sensitivity.1
u/aguedoudedaaSuper interessant. Tu as noté une amélioration depuis que tu utilises ce produit ?1
u/mewingprofileDo you apply it to the whole scalp?1
u/AutoModeratorIt looks like this post is about Research/Science. Before asking any questions, Search the research archives for your topic. Find new research and influential papers. Try posting in the private community for deeper conversations: https://community.tressless.com/ If this post is not about scientific research, please downvote and report. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/jeansarkozy1607could you make some pirfenidone with your own patented vehicle you use for minoxidil sulfate?
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
83r/covidlonghaulersPluripotent stem-cell-based screening uncovers sildenafil (Viagra) as a mitochon...SpaceXCoyote660%2666.3induced pluripotent stem cells2026-03-18↗
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u/worksHardnotSmartOk, so I gotta walk around with a constant boner to get my life back? I'm game. ?positive21
u/Caster_of_spellsWow, that’s some unexpected hopium haha. Who’s gonna volunteer? ?negative16
u/GentlemenHODLCialis is well known in both the lifting and longevity community for being a overall health generator. It makes sense that Viagra would have some similar positive data as well. Both do the same thing - vasodilation. Look into the long-term outcome of taking 2.5-5mg of Cialis daily... You will be blown away by all of the positive health outcomes. I keep it at 2.5 otherwise my boners wake me up at night. It's a all around positive.positive15
u/in2go_outMakes sense. Long Covid/ME/CFS is a micro vascular disease, increasing the potency of nitric oxide would help those capillaries dilate.neutral12
u/reticonumxvI used sildenafil for brain hypoperfusion, it gave me a "pump" feeling in the head similar to Alpha-GPC; I guess it worked over time with all the other stuff. I still have two packs unused.positive5
u/jsgoetzDo you think cialis would have similar benefits? Longer half life would be more ideal i would imagine. I'm already worried about how drastically my vascularity has declined over the past five years. I've been pushing my doc for low dose cialis for this reason alone. ?negative3
u/SpaceXCoyote[deleted]neutral2
u/Silent-Razzmatazz957This may be the stupidest question ever, but do women take this too? Is it basically like just increasing blood flow and thus I guess activity in cells? Is it safe? Could it promote too much growth/cancer? Lots of research to do I guess. Gotta be honest, viagra of all things wasn’t on my radar lolll ?negative1
u/Don_FordIt's been helping with LC this whole time. We've long thought it's why older men have a lower prevalence of LC, because it would hide quite a few symptoms.positive-2
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
84r/stemcellsPlease help me get stem cells to help me walk againAdrianG_23400%4866.1stem cell therapy2026-03-07↗
commentercommentsentimentupvotes
u/ConditionCorrect4065Hey brother stem cells do not work as well as you think they do. The science is not there yet. Save your money and spend it on hookers and happy endings lol. Just kidding but not really though. I spent over 50k on stem cells from a very reputable clinic in Colombia that starts with biox and I got almost no improvement. Just wait a few more years because there are other options that may be available and may be more beneficial22
u/Zergs1Idk if that will make you walk dude7
u/Warren_slIn the mean time a good daily protocol to help with nerve regeneration would be having a good omega 3/vitamin/mineral intake combined with ErinaMAX by Nootropics Depot possibly stacked with their Tigers milk. I’ve had nerve damage in one of my fingers induced by frostbite years ago heal from this and others have had brain and nervous system benefits. I wish you the best in your journey and I’m sorry you’ve endured this.6
u/tfrescaYou’ve posted before. Folks told you that the cure you are looking for won’t come from this treatment.2
u/ZumbgrlHey Adrian, have you looked into studies/trials??2
u/mistersilver007Just wait for nervgen to get accelerated fda approval on nvg-291. This is your best bet.2
u/omarfx007🙏1
u/Confident_Web3110Immunotherapy mx. saw someone walk after having ms. They will tell you if they can help you or not.1
u/SoManyQuestions5200Hey man there is so much misinformation in these comments, its disturbing.do a google search for those medical research institutions that have successfully done restored walking and contact them directly1
u/TemporaryCod5601Hey brother, May our Heavenly Father bless you, may He take your pain away and lessen your burden. May he guide you divinely, with Angels by your side on your journey back to health!!! In Jesus's name, Amen.1
u/Mr-CantaloupeThere is very little chance you’ll be able to walk again with stem cell therapy; the data doesn’t support it. In a few years, maybe, but a lot of the ‘positive’ outcomes in trials are people’s quality of life improving, and a lot of scientists/researchers argue that a big reason for their improvements is from the rehab/physical therapy. That doesn’t mean to give up hope, it HAS been done, and as time goes on the probability will get higher. Your best bet is applying and somehow participating in Clinical trials (I know, easier said than done), and there’s also ‘Neuromodulation’. Those two treatments would give you much higher odds to walk again than stem cell treatment. Please don’t get scammed and give $30,000 to a company in Panama that promises you the ability to walk again.1
u/Severe_Place_119This quote is pricey. Go to YOU regenerative clinic in Medeillin Colombia. Sure they can beat that price for you. It’s a small clinic with specialist doctors.1
u/Ok-Individual-1154Rooting for you!1
u/CyruslegoGod bless. I wish there’s something works for you1
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85r/InterstellarKineticsEXCLUSIVE: Swedish Scientists Built a Scaffold That Convinces Your Body to Regro...InterstellarKinetics4210%266.0stem cell therapy2026-03-07↗
commentercommentsentimentupvotes
u/InterstellarKineticsWhen a bone breaks too severely to heal on its own, surgeons either take bone from somewhere else in your body creating a second wound or they put in a metal implant that your body never fully accepts. Swedish researchers just published a scaffold that does neither. It is implanted completely cell-free but it preserves the biological signals that tell your own stem cells to migrate in and build new bone using the structure as a blueprint. No donor cells, no rejection risk, no second wound site. If this scales to clinical use which current surgical procedure do you think it replaces first?4
u/dunce_charmingCool tech... I hope it can be scaled to normal use.3
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
86r/biohackingImplementing new rules for peptide discussion.RealJoshUniverse390%5466.0subreddit:biohacking2026-02-26↗
commentercommentsentimentupvotes
u/sailzfast69Lol. There is a peptide ad literally below the OP9
u/robarockWhy not add a source for verified providers. Meaning providers that undertake 3rd party testing that can be traced and verifiable. One of the biggest issues currently in the space are users who are excited to try, but end up going with the lowest price. For something you're going to inject in your body, that doesn't make much sense to me.7
u/MrWorkout2024Does that go for reddit adds promoting peptides as well asking for a friend?6
u/Bitter-Ad-6709The rule that really needs to be implemented, is that people need to stop talking about buying RESEARCH peptides and using them on themselves! Which is ILLEGAL. They need to start saying that "they purchased peptides for research, and their 150lbs of lab rats are having x side effects. How would my scientists treat this side effect on our study subjects?" Otherwise peptides will become very difficult to purchase, very soon.6
u/Chemical_Demand_4928Fact, checking? Who’s going to be in charge of that? This is going to get interesting, and that’s a fact.3
u/StoicandFadedPeople getting knocked unconscious👌 People bettering themselves👎 I don't know guys seems Reddit has its priorities out of wack no?1
u/toesfooteI hope these won’t be the same fact checkers they use for Facebook. We all know they lean one way and are complete garbage.1
u/No_Art_3634It stops spammers and scammers. Good rule .1
u/ReptileDragon-646[removed]1
u/little-jugger792These rules make sense. The peptide space is getting sketchy with all the unverified vendors popping up everywhere. I've been using peptides for a few months now and finding legit sources was a nightmare at first. People really do need to do their own research and not just trust random recommendations. Too many places selling who knows what.1
u/Loose_Following317I fact-checked this comment and it has been approved by me…. Proceed…. (Can somebody please verify that I indeed fact-checked this comment?) Thanks1
u/Inevitable-Cost3748But my question is, what if you are a certified and legit vendor. That wants people to have access to affordable and 99% pure peptides? I guess, start our own thread???1
u/curticakesIs this your rule or is Reddit making you do this?1
u/AutoModeratorThanks for posting in /r/Biohacking! This post is automatically generated for all posts. Remember to upvote this post if you think it is relevant and suitable content for this sub and to downvote if it is not. Only report posts if they violate community guidelines. If you would like to get involved in project groups and other opportunities, please fill out our onboarding form: https://forms.biohackinginternational.com/Zu9trV Let's democratize our moderation. You can join our Discord server here: https://discord.gg/BHsTzUSb3S ~ Josh Universe I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/back-2-da-basicsshitty rule
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
87r/ScienceOdyssey✨️China reports experimental stem-cell therapy restoring insulin production in s...Purple_Dust573424850%5965.7stem cell therapy2026-03-03↗
commentercommentsentimentupvotes
u/DreboomboomChina doing shit the US refuses.negative35
u/R3D4FPharmaceuticals in the U.S. would bury this technology faster than an oil company buying up green energy patents. All hail corporations that write the laws, elect the politicians, and are made all powerful by Citizens United.negative12
u/Puzzleheaded-Bus1331How stupid are people in the comments? It's just some preliminary research guys. ?negative5
u/JaseKianThis came out two years ago and diabetes is still rampant. ☹️ (I work at a peds endo & diabetes clinic)negative2
u/PsychologicalMud3108I doubt this is real. I have diabetes. If there's a cure. Let me have it. I'll believe it when I see it. Give it to me and when my blood sugars are stable, I'll believe it. But not before. Oh! [Insert excuse x, y, z here] That's convenient. That being said, Trump is a narcissistic asshole with a brain the size of a tic tac. That needs to be removed from office by any and all necessary means, by the fastest way possible, and put in jail with ALL of his assets seized.negative2
u/Lofi_Joe[removed]neutral1
u/Jynae_Sin-QwaWhile Americans... we're bombing the jets we gave to Iran ...negative1
u/No_Cupcake7037Yay!positive1
u/Common-Sherbert4891Hey… uh can you cure herpes? Asking for a friend. ?negative1
u/[deleted]Wow just wow. While the US acts like Israel and bombs kids for what!? ?negative1
u/[deleted]Thanks to trump we won't get this here.negative1
u/meatmaxxer3000They’ll probably experiment on their abducted children thus producing better organs for them to harvest for the elite.negative1
u/detter1987ând at the same time, americans drink bleach and shut down science fundsnegative1
u/TechnicalChipzNothing but positive comments about China on Reddit. Has China bought stock in Reddit by chance? I don't see anything about the human organ farms that they have? Or the social credit score? So what's the deal? ?negative1
u/MaxBromosecsuali was about to take the image and change the wording to something else....neutral1
u/Jairoglyphics1Never thought I’d be jealous of Chinanegative1
u/migmac71I just wonder where they get all the stem cells needed for such and other studies...neutral1
u/420-eurekaI hope they get it. That is fixed diabetes. The US is going down in the dump because of the pretender and chief.negative1
u/Loose_Plane9790Guess I need to get a passport and prepare myself for a trip to china in the near futurepositive1
u/[deleted][deleted]neutral
u/Ok-Chemical-1020Man, all these advancements right after the USA leaves the WHO..... Wonder what that's all about.negative
u/No-Option-7010Gods that would change my life forever if it worked and the US had it. And yes they would bury it and would rather make money at the cost of suffering of others.negative
u/Supar-Morio69meanwhile in the...neutral
u/Life_Acrobat_2408Incrediblepositive
u/Ethe-Real-6837With the Rapist pedophile Trump who has his head stuck up some child's butt, and refusing science, china is going to wipe the clock of America over the next couple of years with regards o science.negative
u/Print-OverThat's great news.positive
u/KenyMooreHey MAGA are you tired of winning?😂😂😂😂😂 ?negative
u/dirywhiteboyChina been doing their shitnegative
u/Pacety1I’m pretty sure Cuba basically cured lung cancer too. All our enemies are losing so hard.positive
u/IntroductionGrand857China the leader of the world 💪positive
u/EagleEyes0001I’m so jealous. We could be doing this here. But I guess we have other things on our mind.negative
u/JONYLOCOThis is type of news that pharmaceutical companies would want a war to happen and distract everyone in the world...especially America $$$ dictates everythingnegative
u/NightstandsHearts and minds is a better strategy than bomb bomb bombpositive
u/Neither_Relative_252The US doesn't want this.. probably has the cure for alot however the payments are in illness i.e insulin, supplies, accucheck machines, complications, blindness, amputations therefore we will call this a hoax and denounce it especially since we no longer believe in science.negative
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88r/medicineWhat are clinical challenges in your specialty/occupation that needs far more at...Metsaudu330%5365.6regenerative medicine2026-03-17↗
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u/WayBetterThanXangaSingle biggest challenge for the U.S. population is getting patient to exercise more, eat better, and take medications as prescribed. You’ll prevent far more morbidity and mortality with this than any new drug or technology.235
u/FlexorCarpiUlnaristhe combination of multiomics, AI and quantum computing My patients need reliable access to food and a home free from physical violence.194
u/M1CR0PL4ST1CSif I have to read another post talking about the potential for “AI” to revolutionize medicine I might actually have a stroke192
u/basketcase0a0I would like research on how to get rid of AI. The next patient that tells me they asked ChatGPT about their symptoms might cause me to retire.112
u/Nivashuvin”multiomics, AI and quantum computing” has to be the most bullshit trifecta I’ve ever heard. It makes me physically cringe. It also makes me question if most of this OP is written with or by AI which I just can’t take seriously.81
u/RealAmericanJesusHonestly the biggest problem in my life is the technology sometimes. I've been in healthcare since the days of paper charts, med carts and phones that connected to the wall. I feel like the more that technology expands the less time I get actually having patient facing time and the more time I spend looking at screens. And some facilities have these insane expectations around patient messages that assumes infinsae availability to answer questions about what their chatbot diagnosed them with where you have to answer them within a limited time frame. And I use to be able to just call their pcp up and talk med changes but now it's impossible to do that do I'm having to click through a million different epic connects cause I work in psych and my parents aren't good historican. It's a constant routine of clocking boxes opening systems and closing them and writing things in one document and parting them to another because the good EHRs are super expensive and so clinics don't invest in infrastructure so have a basic note aggregator that crashes every 5 seconds. Like the more the technology tries to make my job easier the more I am bogged down with tasks that I'm not reimbursed for at many places and the harder it gets to coordinate care with other provides and agencies and the less face to face time I spend with my patients cause I'm basically held captive by a screen and the every growing tasks of 'innovation"54
u/vonRecklinghausenID...gesture vaguely everywhere25
u/hippoberserkIn anesthesia, intraoperative care is really good. The place that needs the most work is pre-op optimization and conditioning. We can take increasingly sick patients to the OR and get them to 30 days post-op. But whether it is pre-op anemia or nutritional status or exercise capacity, etc so much more can be done21
u/Fragrant_Shift5318Degenerative disc disease lumbar spine . A lot of the treatments just aren’t effective. They can help manage pain, but don’t always prevent disability chronic pain and loss of function.12
u/chiddlerMidlevels with high quality study design I suppose.9
u/tea-sipper42Imo, functional disorders. Very poorly understood by scientists, patients, and doctors alike Highly stigmatized Affect a huge number of people Significant symptom burden, disability, and treatment-related harm Patients often develop long term distrust of the medical system. I have absolutely nothing to offer them except sometimes a few sessions of physio. We don't have any publicly funded programs or centres in NZ that manage these patients. Almost none of them qualify for mental health services. It fucking sucks.7
u/mtbizzleI'm NOT any sort of expert in quantum computing. But do we really have good reason to predict that it'll significantly shape the future of healthcare? My 100% lay understanding is: (1) quantum computers are only useful at performing a function if you provide it an algorithm it can execute much faster than a standard computer; (2) there are very, very few such algorithms that have been created; (3) it's extremely difficult to find/create new algorithms; progress has been exceedingly slow; (4) most work is being done on the computers themselves, not the algorithms (5) ive heard arguments from experts that the type of problem where a quantum computer has a marked advantage over traditional is quite narrow and unusual, so it might be unfounded hope/wishful thinking to believe these will push progress forward in all sorts of domains What tasks are quantum computers going to revolutionize that are relevant to medicine?6
u/KetosisMDThe negative impact of stress on the body.5
u/awesomeqasimIn the US…let’s at least get our patients actual access to care, healthy foods, shelter, exercise etc to get ourselves up to the standards of other developed countries first…3
u/CommonwealthCommandoPsychiatry – Violence. There was a push in the 1960s-1990s to look at violence and aggression as a basic science issue, but it sort of petered out. The implications were scary, the research methods involved high distress for animals, and generally there wasn't much of an appetite for basic psychiatric research. There was some good work on amygdalotomies, but therapeutic neurosurgery for behavioral problems has a loaded history, to put it mildly. There is some basic research, but not nearly enough. We don't know enough about the decision-making process of aggression. Aggression and anger are obviously related, but anger is neither necessary or sufficient for violent behavior. What does anger to do a brain? Can we treat anger? Can we envision an anger-o-lytic? We effectively only treat aggression in inpatient or inpatient-adjacent settings. Nursing homes, group homes, etc., and the treatment there is typically just enough sedatives to keep the patient from hurting anyone. Is there a better way? There are no drug companies looking at any of this, so far as I know. The incentive isn't there, there's too much liability, the patient population as easily accessible, and honestly the will isn't there – SNFs and therapeutic schools are fine continuing to use sedatives instead of more direct anti-anger therapeutics.3
u/FrontierNeuroWhat about quality control, adverse effects, ethical monitoring and data gathering/analysis, etc. regarding the fascinating, deeply alarming, and increasingly popular practice of people injecting themselves with gray market “research peptides” from China without GMP manufacturing, including mainly GLP-1s like retatrutide (yes, the investigational triple agonist that essentially cured MAFLD/NAFLD and obesity while on it in clinical trials) and tirzepatide, but also a whole bunch of others? It appears to be a massive subculture already, as shown on GLP1 Forum and various subreddits.2
u/wrathoffadraBeing protected from RVU based surgeons.2
u/Full_FrontaI_NerditySomething like a continuous glucose monitor, but for women's hormone tracking, would be a godsend.1
u/nattcakesAs great as gene therapies and multiomics are, they aren’t worth a whole lot if there are no medical geneticists. I’m not sure if this is a problem specific to Canada, but some provinces literally have 1 or even 0 geneticists.1
u/MetsauduStarter comment: What are major unmet needs currently faced in your field, that are yearning for new therapies or solutions, but to which either industry and academia has yet to look into? Why in your opinion has it been not paid attention to - is it technological limitations, scientific unknowns or healthcare policy misalignments?-15
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89r/IsaacArthurIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz330%4965.4regenerative medicine2026-03-10↗
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u/NearABEThere is always a limit. There are ways to die other than aging.35
u/tarkinlarsonNo, in short. Your conflating many different problems. The Earth is not overpopulated with humans and can host many more. We are just unfair, greedy and wasteful. We can feed the entire population now, but people starve because of human action or inaction, not the Earth's carrying capacity. Even ecological damage done by humans... that's our fault. Fix that before banning reproduction and you'll solve many more problems. Demographic shifts are economic and social concerns... if you stop and eventually reverse aging... retired people become more productive again. They do not need retirement homes, pensions, etc etc. Healthcare will be less strained. All the fears that Korea Japan and other aging countries have go away. People will likely have fewer children anyway or spread then out over longer times. Assuming we solve cancer too as that's linked with the DNA damage from living a long time... long term soace travel becomes easier and less hazardous. I assume 99% of people will remain on Earth though. The real problem would likely be wealth accumulation in the elderly... already a problem in many places and it would likely increase inequality to even more gross amounts unless there is a major reshift of our economy and social values.30
u/Great-Gazoo-T800They wouldn't even bother trying, given the amount if upheaval it'd cause.5
u/kurtu5Do affluent people have children? There is your answer. Aslo the planet can support tens of trillions. So don't worry about Malthus and his suicidal students.5
u/atlvfI think governments would have better luck simply banning immortality, rather than banning reproduction.5
u/zCheshireAI slop. This account is a karma-farming bot.5
u/Low_Establishment573There would need to be a serious cultural shift if a medical breakthrough like that became reality. Capitalism almost guarantees it’ll become messy. The initial uses will almost guaranteed to be the ultra wealthy, further pushing the wealth inequality ratios. Those same ultra rich will also viciously protect their ability to live forever, AND make sure they’re the only ones who get it. I can even envision them “promising” that everyone has a chance to move up to their level, encouraging folks not to save for the future because there’s no need for retirement savings if you’re immortal. Savings are money the rich don’t have, and they want everything. After the revolution and those vampire lords are “removed”, it gets more muddy. Would people be given the choice, or everyone gets “the cure” whether they like it or not? Even more complicated, who gets to decide what a good number of humans is, and which criteria is used to choose where the replacement population comes from if there are unplanned deaths? Eugenics is never great at looking for solutions objectively.5
u/InternationalPen2072If aging is cured by 2050, that implies a rate of technological progress that makes overpopulation and resource scarcity antiquated concepts. Aging will not be completely solved for a long time, though, and even once it has the population growth rate would max out at a few percent. We’d have time to adjust.3
u/LookOverallDoes the method delay or prevent menopause? As far as population dynamics is concerned what matters is how many daughters each woman has in a lifetime. Longevity matters much less, as do men.2
u/QVReditThey are very, very, unlikely to cure aging. At least within that time frame..2
u/XeruasNo I don’t think so? I think you’d have more people and more generations alive at once but I imagine a new equilibrium would be established with like people choosing to die after a few hundred years? Also birth rates have dropped with improvements to life and resource access, humans usually invest more heavily in fewer offspring instead of having loads so maybe even if we live a long long time we’d still have on average two or less children2
u/BravemountGood luck with that. That's such a massive can of worms that no government with even a hint of wit is going to attempt to enforce that.1
u/wycreater1l11Yeah, one would have hoped it comes just in time together with effective interstellar travel and colonisation. I guess a less radical step before that is to get to a O’Neil cylinder building stage or something and continually expand on that front for some time. I guess there is a lot of material in the solar system that can be converted to liveable surface area. And the step before that would be to optimise the living space and systems that sustain us on earth. Would be interesting to look into the numbers of this hypothetical demographic change (with different parameters etc) to see how much time there is until one runs into serious problems if confined to earth only. If immortality in this sense becomes ubiquitous, I wonder if there will be a major attitude shift in humans where humans generally become more calm and collected and effectively more rational. There is not as big of rush to things anymore and rather one would generally be more careful.1
u/AlanUsingRedditWas convinced this was going to be about "Pop Squad" from Love Death and Robots. You can go read the plot, but the mood is that people can live to 150 or 200, and because of this the number of children has to be greatly reduced to make space for all the old people. Unclear if this meaning is under debate online, but directly answers your question. It has some form of retort to all of your questions, although some of them I found shallow. FWIW, that takes place in a city on Earth. I don't see what the issue even is if we are in space. This is one of several reasons we need that moon base ASAP.1
u/ScottyfromNetworking“Carousel! Carousel! Carousel! Renew!”1
u/SparKestrelAssuming the aging cure keeps people very productive (say - physical capabilities of being naturally 20 to 50 years old), I think a lot of other pressures would need to pile up to cause any strict controls on reproduction. I think 2050’s economy would have enough automation to support the population up to when we can make megastructures in space. If the curse is only for the rich to start, then I think either: market pressures would cause someone to eventually mass produce the thing like generic drugs making it is so expensive due to another limitation that the biological immortals would be a small group, and you can probably have a royalty / peasantry story1
u/Tiny_Scholar_6135If humans stop reproducing they will eventually go extinct as aging is not the only cause of death.1
u/Wise_BassI highly doubt it. The more likely impact is that after an initial surge in population for 10-20 years, it would socially and culturally "sink in" that folks have a much, much longer time to have children and the fertility rate would utterly collapse. People might actually have more children in the long run (and some sub-cultures might just keep on having children), but in any given year they'd likely have much less. That's plenty of time to build denser cities, or off-world habitats.1
u/Subject_Barnacle_600You know, someone might have a more accurate equation, but I think we can actually model this easily enough as humans and other creatures tend to grow exponentially. P=P0 * exp(r*t) But... if you think about it, humans currently die off in x years so... P=P0*(exp(r*t) - exp(r*(t-x))) That is to say, we can approximately subtract off the population from so many years ago where x is the average human lifetime. Presently, we live about 75 years so... P=P0*(exp(r*t) - exp(r*(t-75))) As x=>∞ You might notice that second term vanishes entirely, leaving us back with just P=P0 * exp(r*t) So the question is, how big is that second term? Well, because it's an exponential, most of the gains are towards the end. If humans were immortal presently, you'd still be hard pressed to find anyone from 10,000 BC: https://populationconnection.org/learn/population-milestones/ The only downside is if r grows because people just keep breeding (How many kids do you really need to raise? Can you even maintain that many relationships?!) So, even if we don't have a decreasing population on the planet, the natural growth rate of humans as is will pretty much dictate life on said planet. If you live forever, even if a piano doesn't fall on you, you're still going to be a small fraction of the population compared to the contributions from that first term and the further out on that exponential you go, the more extreme it's going to get.1
u/mjhrobsonWhy? Modern birth rates are declining all on their own; and declining globally. Even in Africa which still has a very high birth rate (by comparison) the birth rate is declining... you don't need to help this along, it is happening by itself. If you don't have death by old age the replacement rate would decrease from 2.1 to 0.2 (or something) because you have stopped people dying of old age, you haven't stopped people dying. Not dying of old age is not the same thing as immortal.1
u/JOliverScottThey'll regulate the immortality first, not the reproduction. Keep the cost of immortality out of reach of the commoners so that the wealthy and elites can continue to rule for centuries while they continue to view the rest of the population like livestock to carry out the labor. Or coupled with AI and automation and there'll be a labor revolution similar to when cars replaced horses except humans will be the horses learning they've been made obsolete. Then watch reproduction regulation begin as there's an overpopulation of idle humans draining the economic resources regardless of how long they live there's still too many of them. Heck, the elites already believe that and aren't shy about admitting they want to reduce/eliminate 80-90% of the current population. So I would expect advances in immortality to be coupled with selective breeding/eugenics policies as soon as they can get the messaging right how noble it is to sacrifice one's self for the greater good.1
u/Eighth_EveEver hear the phrase "the future is here but it isn't evenly distributed." If humanity solves aging, most humans will die of old age anyway. The world where everyone gets it is alien to us. But i bet you would get a discount on the treatments with permanent irreversible sterilization.1
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90r/malehairadviceHow to fix hair loss(most naturally)bankerbilbo620%2065.2stem cell therapy2026-03-29↗
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u/phishnchips_Do this if your hairloss is so minimal that you can afford to try this out and see if it works. Or if its so bad at its a last ditch effort. Otherwise take it from me and just do topical fin/min if you’re concerned about sides.30
u/Random_fellow9Fin and min11
u/Different-Sky4553Nonsense.7
u/randomshitlogicFinally a 6-7 I can related to! Take that kids4
u/SuitableRelease4323Apply rosemary oil daily? You serious?4
u/My_Rhythm875I went through something similar, and honestly focusing on scalp health consistently made a big difference before even touching any meds. Along with things like rosemary oil and gentle scalp massages, I added red light therapy and it actually seemed to help with thickness and overall follicle health. I’ve been using this panel from longevity based, and over a few months it felt like my hair looked fuller and healthier alongside a solid routine, definitely not overnight, but noticeable with consistency.2
u/S_portzyWhat is your story in using these methods, from what NW stage to recovery within a year? For many of the NW stages on the scale you showed (4 and up), gaining ground with the methods you mentioned including pharma is a long road / very unlikely to recover because of the amount of fibrotic hairs a person has at that point. Even from a NW3 it’s at least a 2 year journey for many that aren’t strong responders to fin/min. As a NW3 who’s been regrowing dead zones…I actually am not against any of these methods and I do use some alongside min + tret. Caffeine has been in my routine for a while now and I do think it has value. I use a caffeine serum rather than a shampoo, my latest iteration is I massage it in: caffeine, niacinimide, capixyl ahead of IRL session. I noticed a pickup in regrowth speed after moving to this. I found oral saw palmetto to be of no value and eventually did get some odd mild sides from it…so stopped. I do use it topically though with more success.1
u/First_Tone4187Idk, I felt Great when I went bald1
u/FreedomKnownThis entire post is AI written1
u/I-E-TazzI ain't reading all that, try minoxidil if you don't use it already1
u/futurafrlxDo all of this instead of proven ways to correct hair loss and you will be bald in no time.
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91r/immortalistsECM stiffening accelerates aging. Here is all the science behind it and best way...GarifalliaPapa980%1064.9regenerative medicine2026-03-31↗
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u/GarifalliaPapaI am writing this for anyone interested in the aging biology of ECM: Aging is not confined to DNA damage or intracellular dysfunction; it is profoundly shaped by the physical and biochemical properties of the extracellular matrix (ECM). One of the most consistent findings in mechanobiology is that ECM stiffening acts as an independent and causal driver of aging phenotypes across multiple tissues. As the ECM becomes more rigid over time due to biochemical modifications and remodeling imbalances, it alters how cells sense and respond to their environment. This shift in mechanical signaling alone is sufficient to push otherwise healthy cells toward dysfunction, senescence, or pathological states. Experimental evidence demonstrates that increased ECM stiffness directly accelerates cellular aging. A 2024 Nature-family study showed that artificially stiffening the matrix surrounding chondrocytes induced senescence-like behavior, even in otherwise normal cells. Mechanistically, this involved disruption of HDAC3 regulation and impairment of Parkin-mediated mitophagy, linking mechanical stress to mitochondrial quality control failure. Importantly, this indicates that aging signals can originate outside the cell and propagate inward, redefining how we think about the root causes of cellular decline. This concept extends strongly to stem cell biology. In aged muscle tissue, ECM stiffening significantly impairs regenerative capacity by altering the niche in which muscle stem cells reside. Young stem cells placed into a stiff, aged ECM adopt characteristics of aged cells, including reduced proliferation and increased senescence markers. Conversely, aged stem cells cultured on soft, youthful matrices regain partial regenerative function. This demonstrates that the extracellular environment is not just a passive scaffold but an active regulator of cellular age and function. At the molecular level, mechanotransduction pathways translate ECM stiffness into biochemical signals. Integrins act as primary sensors, connecting the ECM to the cytoskeleton and activating focal adhesion complexes. This leads to sustained activation of focal adhesion kinase (FAK), RhoA GTPases, and downstream transcriptional regulators such as YAP/TAZ. On stiff matrices, YAP/TAZ translocate to the nucleus and drive gene expression programs associated with fibrosis, proliferation, and stress responses, reinforcing aging-related phenotypes. A critical reinforcing mechanism emerges through fibrosis. As ECM stiffness increases, it promotes activation of fibroblasts into myofibroblasts via TGF-β signaling. These cells produce excessive collagen and ECM components, further increasing tissue stiffness. This creates a positive feedback loop: stiffness drives fibrosis, and fibrosis further increases stiffness. Over time, this loop leads to structural and functional deterioration in organs such as the heart, lungs, liver, and kidneys, tightly linking ECM mechanics to age-related disease progression. One of the major biochemical drivers of ECM stiffening is glycation. Because ECM proteins like collagen have very slow turnover rates, they are particularly vulnerable to the accumulation of advanced glycation end products (AGEs). These AGEs form covalent crosslinks between protein fibers, reducing elasticity and increasing rigidity. This process is especially prominent in conditions of hyperglycemia and metabolic stress, making it a central mechanism linking metabolism to structural aging of tissues. Among these crosslinks, glucosepane stands out as the most abundant and impactful in human tissues. It accumulates with age and is strongly associated with cardiovascular risk, especially in diabetic populations. Unlike simpler AGEs, glucosepane forms highly stable and complex crosslinks within collagen fibrils, making it resistant to natural turnover and difficult to target with conventional small molecules. This has driven research toward engineered enzymatic solutions, such as glucosepane-specific lyases, which could selectively break these crosslinks and restore ECM flexibility. Chronic inflammation further amplifies ECM dysfunction. AGE–RAGE signaling activates pro-inflammatory pathways, increasing cytokines such as IL-6 and TNF-α. At the same time, stiff ECM environments influence immune cell behavior, promoting macrophage polarization toward pro-fibrotic phenotypes. This creates a convergence between mechanical stress and inflammatory signaling, embedding ECM stiffening within the broader framework of inflammaging and systemic degeneration. Matrix remodeling systems also become dysregulated with age. Under normal conditions, matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) maintain a balance between ECM synthesis and degradation. Aging disrupts this balance, often leading to excessive accumulation of stiff, crosslinked matrix. Therapeutic strategies targeting these pathways (including modulation of MMP activity or inhibition of TGF-β signa12
u/hoursweeksConnect this with scalp health5
u/AwfullyWaffleyThank you3
u/Bright_Perception147Lumbrokinase1
u/GarifalliaPapaBest scientific research:. [1] Matrix Stiffening Drives Chondrocyte Senescence and Osteoarthritis Progression https://www.nature.com/articles/s41413-024-00333-9 [2] Age-Related Extracellular Matrix Stiffening and Muscle Impairment https://www.fightaging.org/archives/2020/06/stiffening-of-the-extracellular-matrix-contributes-to-age-related-muscle-impairment/ [3] Mechanotransduction Pathways in Cellular Aging and Therapeutic Targets https://pmc.ncbi.nlm.nih.gov/articles/PMC12145204/ [4] YAP/TAZ Mechanoregulation in Cellular Homeostasis and Disease https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.673599/full [5] Mechanopharmacology of Microenvironment Stiffness in Aging and Disease https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70236 [6] Alagebrium (AGE Crosslink Breaker) and Diabetic Complications https://pmc.ncbi.nlm.nih.gov/articles/PMC6812920/ [7] Extracellular Matrix Remodeling by Aging and Metabolic Stress https://pmc.ncbi.nlm.nih.gov/articles/PMC11856005/ [8] Extracellular Glycation Crosslinks and Strategies for Their Removal https://pubmed.ncbi.nlm.nih.gov/16706655/ [9] GlycoSENS: Therapeutic Strategies to Break AGE Crosslinks in Aging https://lifespan.io/our-research/intro-to-sens-research/glycosens
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92r/MultipleSclerosisIs this it? When doctors tell you nothing more can be done, go to physio, and go...mermaidoutofwater000380%3364.7stem cell therapy2026-03-12↗
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u/ChrisEUI am (and have been) in a very similar boat. PPMS, wheelchair, heavy fatigue, no DMT and nothing the docs can do for me. It may be the end of the line for the docs, but not for me. I still have the rest of my life to live and I refuse to sit back and die. I am working a different job now (as a specialist with specific knowledge that's rare, at home, part time, just enough money to live, but indispensable for my employer), so I don't have to worry about that at all. I can work there until the cows come home. One problem less to solve. Yes, I am lucky about it. I am using motorized wheelchairs that are cool and fun to use (This thing and a souped up device that pulls my manual wheelchair up to around 50km/h). I learned lockpicking for manual dexterity and hand/eye coordination. I am drilling deep into current MS science and AI technology, writing systems that actually help people with their work. I develop drone software that's autonomous. Just because the docs can't help me doesn't mean I'm helpless - or useless, for that matter.16
u/Adventurous_Pin_344Hi friend. I was diagnosed almost 14 years ago, started having symptoms 18 years ago, and I deal with a lot of the same shit you are describing. I appreciate the optimism shown here, but unfortunately, there aren't any medications that address our disease stage. We at least are at the next stage of MS research. Current meds do a great job stopping acute inflammation in the form of lesions, but they don't stop whatever is causing smoldering inflammation. (Ocrevus can a little, but they aren't sure why...) You could do what I do, and spend far too much time on clinical trials.gov, and look for trials that are recruiting for non-active SPMS cases I am going to try and get into the next stage of CAR-T trials and have been trying to get into a Frexalimab trial. Frexalimab is a BTK inhibitor, a class of drugs that show promise with slowing smoldering disease by limiting microglial activation. Unfortunately, the first one of these to come up for FDA approval (Tolebrutinib) was denied in December. The FDA said it created too high of a risk for liver damage. I also subscribe to Gavin Giovannoni's Substack "MS Selfie" because he is a huge believer in our stage of MS being the "real MS." For now, I keep working hard to stay active and mobile, and use what symptom specific treatments I have - Botox for my neurogenic bladder, trulance for my neurogenic bowel, Tizanidine for my spasticity. But it's frustrating and scary to not have any meds to slow our progression. For now, keep an eye on trials! And read Dr. G's stuff!8
u/cbrooks1232PIRA is short for Progression Independent of Relapse Activity. It’s also sometimes referred to as smoldering MS. If I were diagnosed as having PIRA MS the first thing I’d do is get a second opinion. From an MS specialist neurologist. If PIRA MS was confirmed, I’d find an MS clinic/hospital that was considered cutting edge and learn about potential treatments that many of us with more controllable MS might not know about. Your doctor’s response mentioned in your title is simply unacceptable and uncalled for and even if PIRA is confirmed I’d find another doctor.8
u/Amazing_Lead9946Hey, NO, thats not it That's all doctors can do YES But there is a lot for you to do youll find out that there are many things you'll have to do Think of yourself right now as a high-performance athlete no bad nights, stress minimized, good healthy ending aware of inflammation in any form No its NOt IT If you believe it your not doing enough research7
u/JCIFIREThat's pretty much it. I was on Ocrevus for 7 years and only got worse. No new lesions in years. Probably had MS for 20 years before I was diagnosed at 43 but never had any symptoms so I didn't know. I am now on Zeposia and still just getting worse. Getting worse coincided with going through menopause at about the age of 48. My walking, balance, and nerve pain are my issues. Nothing more they can do. I don't get MRIs anymore because there is no point. It's not going to change my treatment. This disease has ruined my life and it fucking sucks. I'm so sorry you have it too. Unfortunately aging is not on our side. I have read that getting worse usually hits between the ages of 45 and 50, and that's exactly how it was for me.5
u/Dramatic_Mixture_877Have you tried dalfampridine (Ampyra)? I asked my first neurologist about trying it, and it's a gamechanger! I accidentally ran out last year with no refills, and by the time I got some back in my system again, all my coworkers were worried about me - it's not just walking that it helps, it seems to be overall coordination for me. I've also learned that wearing inappropriate footwear will really affect my walking speed, overall tiredness, and balance. My first neurologist kept telling me that if I would go to the gym and work out, I'd have more energy - I told him that if it were that easy, I'd be there with bells on every day! But it's an either/or in my case; I can go walk/work out after I get off work, or I can tend to the dogs, chickens, and us getting fed. There's no and in that equation. My current neurologist totally gets where I'm coming from - he let me try a gamut of stimulants; nothing has helped. Modafinil, armodafinil, Sunosi, Ritalin, Adderall, Adipex, nothing. I asked to go back on the Adderall because it helps me stay focused at work and smooths out my typing for some odd reason (unless you count AuDHD, lol).3
u/mermaidoutofwater000Thank you, I also needed to hear this! I agree and thanks for reminding me that do much is up to me ( all of us) . Like eating right and not stressing, getting rest. I just want to make sure that there isn’t also a therapy that can help as well.2
u/mermaidoutofwater000Thanks for sharing and thanks for the optimism! It is up to us to keep living and adapt and it sounds like you truly have. Your work sounds really cool!2
u/Affectionate_Wish795Please watch Living Proof documentary on Prime. My naturopath also has had success with her MS patients. Theyve gone from using a cane/wheelchair to now jogging. Im hoping for the same or similar results with PPMS.2
u/alex_rasti13Complemento la medicación con mi estilo de vida, práctico ayuno, tomo el sol, hago dieta carnívora y ejercicio. Estoy diagnosticado hace más de 15 años y estoy muy bien. Creo que el estilo de vida es muy importante, siempre combinado con la medicación.2
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93r/HFYChild of the Stars 4 (Revised)Maxton1811790%1264.6induced pluripotent stem cells2026-03-21↗
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u/Great-Chaos-DeltaSo far nothing out of the oryginal one but hey it still super coolpositive7
u/HFYWaffle/u/Maxton1811 (wiki) has posted 131 other stories, including: Child of the Stars 3 (Revised) Child of the Stars 2 (Revised) Child of the Stars 1 (Revised) The Impossible Planet 11 The Impossible Planet 10 The Impossible Planet 9 The Impossible Planet 8 Denied Sapience 24 The Impossible Planet 7 The Impossible Planet 6 The Impossible Planet 5 The Impossible Planet 4 The Impossible Planet 3 The Impossible Planet 2 Child of the Stars 19 The Impossible Planet Denied Sapience 23 Child of the Stars 18 Denied Sapience 22 Child of the Stars 17 This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.neutral3
u/ProfessorWorking3763"...the lab door once again slid open to reveal a suited one now staring directly at me." Samael: Ooh DoorDash!neutral3
u/KanadianKitsuneit demonstrates remarkable resistance or even outright immunity to [...] the synthetic VX nerve toxin. Breaking News! Organism without nerves or muscles survives chemical agent that disrupts the function of motor neurons!positive2
u/UpdateMeBotClick here to subscribe to u/Maxton1811 and receive a message every time they post. Info Request Update Your Updates Feedbackneutral2
u/kristinpeanutsThanks for the chapter!positive2
u/animeshshukla30Great chapter! And i agree, no matter how evil the scientist, no one is stupid enough to be thrilled about the military turning the alien organism into a weapon.positive2
u/ChiliAndRamenIntrigueneutral1
u/un_pogazWhen you catch the child with their tendrils in the cookie jar.negative1
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94r/IBSResearchHow many diseases are masked by an IBS diagnosis?jmct16590%1864.6induced pluripotent stem cells2026-04-01↗
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u/jmct16Finally published. Made with Deepseek, Claude, and OpenEvidence. I think it's the most exhaustive list you can find on IBS mimics. Christensen (1994) and Camilleri and Boeckxstaens (2023) served as starting papers, and then I added a few more entities that I remembered. u/Robert_Larsson, if any diagnosis is missing, please let me know. I've been wanting to make this post for quite some time.neutral11
u/ariaxwestThis is awesome! I've also thought about this a lot as I've had at least two diagnoses missed and been diagnosed with IBS. I wasn't diagnosed with celiac disease until I was 30 years old, despite being in constant pain and suffering from reduced nutrient absorption since I was a baby. Under inflammatory and immunologic entities, you should include food allergies and hypersensitivity to metals and chemical compounds. My daughter had been diagnosed with IBS-C, but in reality she had casein allergy. Dairy free diet ended her constipation. I don't think we ever would have figured this out if she hadn't had allergy testing. Starting a few years after going gluten-free due to celiac disease, I again had severe diarrhea over a long period of time. This time I became so ill that I almost died, and again of course was diagnosed with IBS-D. This time it was due to nickel hypersensitivity. I was finally diagnosed by a dermatologist. Nickel hypersensitivity in particular causes so much intestinal inflammation and symptoms identical to IBS. One study I read found previously unknown and undiagnosed nickel hypersensitivity in almost 40% of patients who had been diagnosed with IBS.neutral10
u/jmct16Missed some (by Grok) Trehalase deficiency: Malabsorption of trehalose (found in mushrooms and certain insects), causing fermentation and IBS-like symptoms after specific ingestion. Biomarker: Trehalose hydrogen breath test or genotyping. Status: Rare but under-recognized; in active separation in centers performing expanded disaccharidase testing. Dyssynergic Defecation (also called pelvic floor dyssynergia or anismus): Impaired coordination between abdominal push and pelvic floor relaxation during defecation, leading to straining, incomplete evacuation, and symptoms indistinguishable from severe IBS-C. Biomarkers: High-resolution anorectal manometry + balloon expulsion test (BET); defecography. Status: Fully separated in guidelines for refractory constipation. Rome IV now allows diagnosis alongside IBS-C. Biofeedback therapy is highly effective (success rates >70%), often curative, and is recommended before labeling patients as having refractory functional constipation or IBS-C. This entity exemplifies how "IBS" can be an artifact of incomplete physiological testing. Persistent post-viral or post-COVID gastrointestinal symptoms: Low-grade inflammation, dysmotility, or barrier dysfunction following acute viral gastroenteritis (including SARS-CoV-2). Shares biology with classic post-infectious IBS (PI-IBS) but has surged post-pandemic. Status: Nosological debate ongoing (similar to PI-IBS); some propose "reactive gut disorder" or "long gut" as distinct labels. History of infection plus exclusion of other causes is key. Symptomatic uncomplicated diverticular disease (SDD): Chronic abdominal pain, bloating, and altered bowel habits in the presence of diverticula without overt inflammation. Status: Largely consolidated separation (already noted by Christensen in 1994), yet still frequently mislabeled as IBS in older patients. Cantu syndrome-related GI dysmotility (mutations in KCNJ8/ABCC9 — KATP channels): Gain of function leads to intestinal contractility dysfunction. Status: rare, but an elegant example of channelopathy beyond SCN5A/GUCY2C; reported in humans and murine models with severe cold. Dyssynergic defecation (ou pelvic floor dysfunction / anismus): Contradição na coordenação do assoalho pélvico durante evacuação, mimetizando IBS-C grave. Biomarcadores: manometria anorretal + teste de balão de expulsão. Status: fully separated em guidelines (ACG recomenda testes fisiológicos em refratários); biofeedback é tratamento curativo em muitos casos. Prevalência alta em IBS-C refratária. Eosinophilic activation in IBS-D (without frank eosinophilic gastroenteritis): Increased activated eosinophils in the jejunal/colon mucosa, correlated with severity in IBS-D. They produce CRF and contribute to hypersensitivity. Biomarker: eosinophil count/immunohistochemistry in biopsy + activation markers. Status: in advanced research; not fully isolated, but explains subgroup with low-grade inflammation. Dyssynergic defecation (or pelvic floor dysfunction/anismus): Contradiction in the coordination of the pelvic floor during defecation, mimicking severe IBS-C. Biomarkers: anorectal manometry + expulsion balloon test. Status: fully separated in guidelines (ACG recommends physiological testing in refractory cases); biofeedback is curative treatment in many cases. High prevalence in refractory IBS-C. Giardia lamblia (giardiasis) a classic — yet frequently under-appreciated — example of a condition that migrates out of the broad IBS diagnosis, particularly in the context of post-infectious IBS (PI-IBS) and chronic diarrhea workups. Dientamoeba fragilis: Causes chronic diarrhea, abdominal pain, and IBS-like symptoms; known for propensity to cause prolonged infections. Frequently overlooked because standard labs may not perform the required stained smears. Biomarker/Diagnosis: Microscopy of stained fecal smears or PCR. Status: Emerging recognition as a treatable cause of chronic symptoms misdiagnosed as IBS. Cryptosporidium spp.: Waterborne parasite causing prolonged diarrhea, especially in outbreaks or immunocompromised patients. Strongly associated with PI-IBS development, with symptoms persisting long after clearance. Biomarker/Diagnosis: Stool antigen or PCR. Status: Well-documented trigger for PI-IBS; separable with specific testing in chronic diarrhea workups. Cyclospora cayetanensis: Similar to Cryptosporidium; causes watery diarrhea and fatigue, often linked to contaminated produce. Can lead to prolonged or post-infectious symptoms. Biomarker/Diagnosis: Stool microscopy or PCR. Entamoeba histolytica (non-dysenteric amebic colitis): In endemic areas or travelers, it mimics IBS-D with chronic diarrhea and pain without overt dysentery. Non-invasive forms are particularly hard to distinguish from functional disorders. Biomarker/Diagnosis: Stool antigen/PCR (distinguish from non-pathogenic E. dispar). Status: Classic mimicker; guidelines recommend testing in appropriate risk groups.negative9
u/VisiblePlatform6704Another one that may need to be included:  A1 Casein intolerance: A1 casein intolerance is a condition where digestion of the A1 beta-casein protein found in most European dairy cattle releases beta-casomorphin-7 (BCM-7), a peptide that activates opioid receptors in the gastrointestinal tract and causes symptoms mimicking lactose intolerance. Unlike true lactose intolerance, which stems from insufficient lactase enzyme activity, A1 intolerance is linked to the A1 beta-casein variant produced by a mutation that occurred in European cattle roughly 5,000–10,000 years ago, whereas A2 beta-casein (found in Asian/African cattle and some modern breeds) does not release significant amounts of BCM-7 I've got a VERY strong case of this, so much that even eating something like chips that have "milk powder" would provoke swollen intestines,  diarrhea and other stuff.  Meanwhile,  drinking/eating A2 casein milks is completely fine.neutral6
u/GastronomicusAll of them. That's what IBS is - a collection of GI issues without a diagnosis of disease. Every one of them has a disease behind it, but they're sometimes difficult to detect.negative5
u/ariaxwestAnother possible missed diagnosis: congenital anatomical differences. Possibilities include intestinal hypermobility, common in people with HEDS, Hirschsprung’s disease, and intestinal malrotation.neutral4
u/Ambitious-Ad-4301I have to say, I often wonder how easy it would be to miss that you may have colon cancer due to some of the effects of IBS and what is normal for you is also what is sometimes the first signs of cancer.negative4
u/Robert_LarssonWhat I can come up with from memory only: SLC5A1 Gene causing Glucose-Galactose malabsorption (carb enzyme category) DGAT1 mutation causing diarrhea Stem cell proliferation (covered by the original causes above in part) Cystic Fibrosis (doesn't mask IBS but GI issues and EPI are common and forgotten) Adrenal Insufficiency (GI issues often forgotten and labelled functional) We could probably expand this list by going more into detail on some categories like the neuropathies or immune activation, not to speak of the intestinal microenvironment where dysbiosis, parasites and infections can be of so many origins. The problem is that we are diving in from meta to minutia so quickly and frequently, it becomes hard to keep track. Nice work buddy, we should be doing more of this to keep it moving in future.neutral3
u/magskiiExcellent. Another one not on the list, from the UK: My mum was initially diagnosed with IBS when what she actually had was a huge gallstone. No one bothered to offer any tests other than basic bloodwork. They only figured it out when she had an ultrasound for a completely different reason. The technician spotted and mentioned it, assuming my mum already knew because it was so obvious!negative2
u/jmct16u/BulkySquirrel1492 Finally, a detailed review. It considers mimickers to be rare. There are many entities to be considered beyond a 'positive IBS diagnosis'.positive1
u/frankwittgensteinIt's a useful summary which goes on to show the political and economic dimensions of diagnosing people with "severe DGBI". I'd say it's a more difficult task to organize this topic into fully distinct entities than in this table, as there is some inevitable overlap, e.g. some of the congenital diseases here will also be neuropathies (Hirschprung's), some of the metabolic/neurological may also be congenital/hereditary (mitochondrial diseases), and so on. Another thing is that in some cases etiologies are listed alongside diseases/phenotypes, e.g. myenteric plexitis is likely etiology of some cases of enteric neuropathies, like CIPO. Apart from that, the immune system may also be a driver of mitochondrial diseases (Hanaford and Johnson 2022, for instance). Which brings us to another point, that there will also be some overlap in etiologies within a single disease, i.e. GI symptoms in some autoimmune diseases will likely be a mixture of mitochondriopathies, connective tissue autoimmunity and neuropathy. Within diseases with neuropathy, etiologies can span both large- and small-fibers, or be limited to small-fiber neuropathy of ENS and/or PNS. You could also add autoimmune/rheumatic diseases into the table (in fact, I have an entire book on gastrointestinal manifestations of rheumatic diseases) — Sjogren's, RA, Enteropathic Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, SLE, Scleroderma, Myositis, Vasculitis. Again, they will often have a mixed etiology, e.g. in Sjogren's, GI symptoms being the outcome of a mix of xerostomia, small-fiber neuropathy and probably connective tissue autoimmunity, which will also inevitably vary between patients. On a more microscopic scale, mitochondria will likely be affected too. IBS diagnosis probably won't mask them, but some clinicians like to refer to GI symptoms of people already diagnosed with those rheumtic diseases as IBS, FD and so on, which is obviously incorrect (this opens another discussion on where to draw the line between "comorbidity" and the actual symptom in a subset of patients diagnosed with the disease). There is also more recently described Yao Syndrome, which actually has similar genetic mutations to Crohn's (NOD2 gene). On a side note, I'd be cautious with overly relying on commercial LLMs used for similar tasks, as they are subject to capitalist logic as everything else (the same logic, that within the medical framework gave us DGBI in order to save healthcare spending per capita) — their main purpose is to appeal to investors. They are often correct (I find them useful on occasion too, mostly for preliminary looking for a query that will be too specific for standard search engines), but they will bridge the gaps in data with making conjectures, as what attracts investors is a technology that sounds smart and confident, even when data on the topic is pretty limited. They may also share biases of the research they are aggregating.neutral1
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95r/collegeresultsasian girl from city bags harvard, stanford, brown, JHU, berkeley, ucla (NO hook...butterflygirl2468350%3664.6regenerative medicine2026-03-27↗
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u/[deleted]Nice try, ChatGPT ad for college consultant40
u/jcbubba“DM me to get the info on my essay writing consultant, who is totally not also me”33
u/FirefighterFine3207🧢🧢🧢25
u/TangerineKitchen2260Btw everyone, I saw her "evidence" in her dms. It's fucking edited and bullshit.21
u/TangerineKitchen2260C A P Fucking bullshit......20
u/Sea_Response3421UC Berkeley doesn’t choose its SEED scholars until later in May18
u/Comfortable-Ebb-5949holy cap14
u/pythonlover001Sounds fake11
u/Fresh_Market6588This 100% carried into my college interviews and onward, which I will be using for the rest of my life. That was honestly the secret sauce.  There is no magic trick and stop trying to pretend like there is something behind the curtain. Idc if this fake or not but if you're gonna keep vehemently asserting that its not fake in the comments then ur definitely larping lol.10
u/Standard-Song-8590Larping final boss10
u/Decent-Ad-843Does a college counselor really help this much ?9
u/No-Biscotti-6891CAP show proof9
u/Ill_Substance_1833Something is missing for sure from this story.6
u/hEDS_StrongYou lost me at “recruited athlete” Congrats6
u/SnoFox20Nice try diddy2
u/Ready_Return_5998Congrats! What were some of the "cool gigs" if i may ask?2
u/yodatsracistThis has gone a little bit off the rails. We're locking this comment thread (at OP's request).
u/Independent_Math_840Recruited athlete. 🙄
u/butterflygirl2468[deleted]-2
u/Sad-Low5753giving you the benefit of doubt -> congrats!-2
u/P1anetfa11Lol ppl salty AF-3
u/butterflygirl2468The intention of this post is to not persuade people into believing what I have written. It is to provide insight to my experience and potentially help others. If you have questions, I'll try to get back to you (I have a lot rn). Won't be sending anymore proofs because a bunch of people have criticized me for faking them by "proving" the REAL one with old acceptance letters they found on the web lol-8
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96r/Ayahuasca24 hours upon returning from an aya retreat, my partner of 5 years got very hate...This-Sky9770200%7364.5stem cell therapy2026-03-25↗
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u/INKEDsageSounds like very manic behavior. Probably has an unbeknownst underlying condition that is a contraindication to the medicine. Ayahuasca can exacerbate certain conditions. In my opinion, your focus should be on yourself and your son. Find as many resources as you can. Reach out for support. Get yourself and your boy safe. Your husband’s behavior might be concerning and you obviously want to help but right that is at the bottom of the list. You don’t have the luxury of trying to save him when you have your boy to care for. Also, your husband does not seem like he’s a in good space and is a liability to yours and your son’s wellbeing. I’m so sorry that this is happening to you both. Take good care and I hope you find everything you need soon.42
u/A_MurmurationWow. In ceremonies I have attended the facilitators were VERY clear about this great advice: First three days back is about grounding. Touch grass, no media, journal. Next two weeks to three months, no major decisions like job changes or ending relationships or giving away all your possessions. An hour long integration call at the two week mark to check on you. I really valued that they did that22
u/Soul_trustWas this Rythmia? Sounds like it was. They've totally screwed with him. The place is hell on earth, and I recommend you research it so you don't personalize what your partner is going through.8
u/BearsOwlsFrogsI don’t know where you’re from, but in a lot of places he can’t legally kick you out without notice. If he’s wanting to pay for an apartment, get the money up front for a years worth. He might quit paying a few months in. He most likely had you move back in to get unpaid childcare and housekeeping out of you. It was probably easier for him to be civil when he was gone 5 days a week. Even if he starts behaving again, it’s obvious he’s not safe as a partner.6
u/Sufficient-State3720So sorry you are going through this now. Please name this centre! Did they sell this stem therapy themselves that sounds crazy? Sounds like he needs a lot of extra support with his mental health urgently and integrating the retreat and you yourself need your own support too! I favour small retreats of max 5 people with at least a week or two afterwards with trained experienced grounded therapists who can give 1:1. The reality is overpriced retreats of 30 plus where the company ceremony control is poor. The shaman if there is one will just sing for the space and not individually so much. People leave for the real world too soon while they are still vulnerable. This is what happens with ayahuasca as a westerner business. I hope things settle down and his senses are regained and stress goes away5
u/Tiny-Art7074Just leave him. Seriously, stop wasting your time. Hate to say it but not everything is fixable or worth fixing just because its broken. He doesn't seem to be able to care about you and is dragging you along only so he isn't alone. Not worth it.3
u/astraladventuresThe post ayahuasca break up is amazingly common.3
u/Sea-Research8302im really sorry for you. I'll keep it brief because it's pointless to judge such things without hearing the "whole" truth or at least only your opinion and not his.  From experience, I know that after such retreats, the nervous system can be raw, and one might therefore go into attack mode as a form of self-protection (more unconsciously than consciously).  Perhaps there's more to it, though, and he had an "intuition" that now makes him believe he's better off without you.  Unfortunately, that's something you have to accept.  Bipolar disorder also sounds suspicious. I would wait and see; there's probably not much more you can do if he's actually in a different state or even psychotic due to the retreat (I've experienced this with my husband repeatedly...). All the best!3
u/sbarretI could not read everything, but really, you should focus on your kid, there's some narcissist/maniac behavior there but really focus on the kid and what's best for both of you. Ayahuasca has pretty much nothing to do with this, it's a brew it doesn't turn people into assholes2
u/Enough_Extent_2827Op I felt like reading this post the vernacular wall so much about him and his interests. . . I wonder if you might benefit from thinking about what you want and deserve.... Like : do you want and deserve a partner with this type of interest and response to you? I hope I'm not bulldozing here. Just hope you are caring for your on wants and needs and boundaries. It sounds like he has a lot of unacceptable behaviours.2
u/Revolutionary_Bike54Are you sure he went to the retreat? He travels with work, while you're home. He goes back and forth about the relationship.2
u/Ashamed-Internet8373Gurl your husband bought back some bad forces entites with him . The shamans can only send out an invitation they have no control of who accepts it . Unfortunately judging from what you posted things are only going to get worse for him . He will isolate more & spiral further & his mental health will slowly deteriorate. I would advise you to be patient. Also have noticed any supernatural things happening in your home or happening to him or you?2
u/Frequent_Truth808Sorry you're going through this. Hope you can find some sort of peace and grounding. Also, altered states are sacred. Selling and offering services during that time is not okay. It's actually a huge red flag. That being said stem cells for autism is not snake oil. There is research showing positive impact. The first thing that came up when I searched online: Stem cell therapy for autism remains an experimental treatment that has not received FDA approval for this specific condition, though clinical trials have shown promising results in reducing symptoms.  The only FDA-approved stem cell products in the U.S. are blood-forming stem cells from umbilical cord blood used for blood disorders, not for autism spectrum disorder (ASD).  Research indicates that mesenchymal stem cells (MSCs) and umbilical cord blood may help alleviate autism symptoms by reducing neuroinflammation and improving immune regulation, rather than curing the underlying genetic causes.  Several studies and anecdotal reports suggest improvements in social interaction, language skills, and sensory issues following treatment, but these findings often come from small trials or non-controlled settings.2
u/ProcrastingineerHonestly it sounds like you are in a relationship with a narcissist. You are seeing the result of the mask being forcefully ripped off. You're probably right that he has hated you for a long time, and he can't keep up the facade after being shown his true self. Psychedelics often can't really fix narcissists, but they can sure destroy them. You are likely watching the building of a new and stronger mask. The yoga studio and Buddha statue are almost comically stereotypical outcomes when people who really can't handle psychedelics get exposed to them. also see:2
u/erinaceousfoxI'd be concerned about the manic part as psychedelics triggered my bipolar years ago. First off, they failed with the screening process. Were they to be serious they would ask about family mental illness and screen out people with bipolar running in the family. Here's a good list to look out for in regards to bipolar: Elevated/irritable mood beyond baseline Decreased need for sleep (not feeling tired) Racing thoughts / rapid idea switching Inflated confidence or grandiosity Increased talkativeness / pressured speech Distractibility Impulsivity / risk-taking Economic behavior: Increased spending / impulsive purchases Unrealistic financial decisions or investments Reduced concern for consequences of money use2
u/Big-Performance5047Wondering if he is addicted to something1
u/TuckerStewartYour partner sounds very deep in the medicine, and you mentioned his family has a history of bipolar. After searching in the comments to confirm, I knew you were referencing Rythmia based on the stem cells. Rythmia is the most incredible, magical, beautiful, and supportive ayahuasca SANCTUARY in the world. They have a specialized program that in the end, you are told to ask the medicine to show you who you've become. Looks like the medicine is showing him EXACTLY who he has become- a belligerent, temperamental, abusive loser who wreaks havoc in his family's lives. I hope he sees who he has become, and he gets the proper support and help he so clearly needs. You also see who he has become, and without self-awareness he could stay this way. The medicine is just a tool. A beautiful, hard tool that can completely change the course of your life. It's up to him to get help and look at himself fully in the mirror. I hope you take care of yourself. And anyone reading, this, Rythmia is phenomenal. I go once a year for a tune up and it has changed the complete trajectory of my life. I am forever grateful for this place. It is insane there are so many shit-talkers of Rythmia who have NEVER been (they can't afford it lol) and are victims to life and are so quick to BLAME. Do the inner work and get honest.
u/miggins161014 day old account with no other posts or comments? Something smells off here to me-4
u/NonGMOman_Brand New account. All these Bull shit posts using AI Enough already!-10
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97r/Skincare_AddictionWhat can I do about these horrendous eyebags?Responsible-You618180%7764.2PRP knee treatment2026-03-28↗
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u/Aim2bFitThose aren't eye bags but dark circles. Eye bags mean that there are physical bulges or pouches raised on your skin under your eyes. Dark circles can be caused by: 1) pigmentation problems, which you can try to fade using any anti pigmenting product (trial and error as everyone reacts differently to the same products) 2) genetics which, not much you can do about it other than acceptance 3) lifestyle like not getting enough sleep or living a stressful life or being deficient in certain nutrients, so a lifestyle adjustment is needed to remove them 4) hollowing of the undereye areas, which can be corrected with either fillers or fat grafting81
u/Internal-Crow-3333If it is genetics, its kinda hard to get rid of45
u/emeraldforrestDon’t think its too bad. You have beautiful eyes44
u/IwKuAoYou do not have any “bags”, your skin is smooth and tight. You are not a candidate for fillers. You might benefit from PRP to help with the darkness. But concealer is your best friend!15
u/UJKRIOp do you suffer from allergies often? If yes, then try to get that under control first and use a good eye serum like the aminu one.7
u/desertprincessxoYou have beautiful eyes! hydrate and don't let the beauty industry standards affect your self esteem :)5
u/moon_witch_26They are not "horrendous"!!! You have beautiful eyes 😍 and many people happen to find these darker under eyes absolutely gorgeous 🥰4
u/moschocolate1You don’t have bags. Those are dark circles.4
u/s1696jMine looks the same. Ive tried multiple eye creams nothing really works. I think it gets better when the health conditions get better. Im working on that now.3
u/sono_onaThis is sadly just being an adult. My makeup doesn’t even cover mine anymore3
u/smugglingkittensYour eyes are stunning3
u/callamouragirl they fine if you wanted to cover it with makeup i would recommend a peach concealer on top to neutralise the colour with ur skin and then ur regular concealer over it3
u/Justmelululu1Work less and hydrate from within2
u/jsepublicWork the muscle and lymph underneath. I'm figuring all this out as we speak. Also, hyperpigmentation.2
u/Worldly-Emu-2740Seems like we have similar skintone and undereye pigmentation ! Twins. You can read about different types of under eye bags and pigmentation. I would do that first .. I also don’t see any eye bags love I think it’s pigmentation I saw improvement w beauty of Joseph revive eye creme. Pls note it has retinol and niacinamide, so pls ease into it. Even at peak use, im only using 3-4 times a week.2
u/carabear85Those are dark circles but eye bags2
u/evicciFor my dark circles, I useMurad’s Vita-C Eyes Dark Circle Corrector. My skin is lighter, and my under eyes are bluer, so maybe a retinol or green-based serum or concealer would help you more. For daytime I use a tiny amount to tone down the dark circles. At night I use more as a mask because with consistent use it will lighten. But they only have light-skinned results photos on their website, so maybe shopping for a vitamin c serum design to treat under eye dark circles & proven to work on variety of skin tones would better suit you.2
u/latheez_washarumi only see eye hollows sis :| well at least you don't have bags. let's try and look at the positive 😭2
u/cassattaYou don’t have bags. Your eyes have some dark circles. See if you can find a sunscreen that doesn’t sting your eyes and wear a concealer over the sunscreen. UV and blue light protection will help. But genetics can be a strong and play a role in whether or not you can completely eliminate them2
u/Effective_Grand_9726Those aren’t dark circles they are NATURAL EYESHADOW2
u/Lazy-Substance-5062Hydrate a lot. The more i use concealer on that area, the more it gets pigmented/dry/irritated. What worked is polynucleotide with peptides skin booster undereye injections. Its a korean invention but not globally recognized/fda approved. Look into clinics that does this. Great for internal hydration and brightening2
u/Crafterandchef1993Eye cream and eye brightener2
u/Ashenshapedashthey are lovely2
u/Aromatic-Muffin-538Go to a dermatologist who does beauty treatments, I recommend micro needling or plasma or maybe salmon dna. I have similar dark circles and she suggested plasma (PRP) or salmon DNA. Apparently the skin under our eyes are super thin and the darkness is our veins showing, so we need collagen or more fat in the area (something like that).2
u/captain-ignotusIf it's any consolation, I was too distracted by your pretty eyes to notice any dark circles ahaha2
u/TvgirllovrPRP treatment2
u/jess_m19I just wanted to say I think they’re really cute! Ik you feel a different way about them because they are on you, but I promise no one else sees them that way2
u/dcgradcConcentrate on what your positive traits are . Beautiful eyebrows1
u/ShrimpCerealFlakesIf you happen to use lash serums, the ones containing prostaglandins tend to darken the pigment around the eye area which can probably make your concern worse, speaking from experience as well as a fact1
u/Slow_Medicine820Looks like it’s genetic. Have been trying different eye patches and they definitely help brighten the darkness. I’m currently using Nurse Renee’s eye patches and they are so good!!! Tried the charlotte tilbury ones they are ok too but didn’t feel hydrating enough.1
u/AutoModeratorWelcome to r/skincare_addiction! We'd like to take this time to remind you of a few things: Do not ask for a diagnosis/treatment advice for acne or other medical conditions, and do not play doctor What constitutes medical advice? "What is this?" This is asking someone to diagnose the issue, and is medical advice. "What should I do?" This is asking someone to advise treatment, and is medical advice. "Should I go to the doctor?" This is asking if you should seek treatment, and ergo, medical advice. If you would ask the question of your doctor, it falls under this rule and not allowed. As a general rule, asking for medical advice from internet strangers is never a good idea. If you have questions regarding your acne or other medical condition, you are advised to contact your healthcare provider. If you are a medical provider, we would gently remind you that users are not patients, and you should not be offering medical advice to people who are not your patients. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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98r/realmadridMadrid’s Medical Staffs Have Completed The Treatment Of Mbappe(Right Knee this t...dracaryzzzz712990%3564.1PRP knee treatment2026-03-25↗
commentercommentsentimentupvotes
u/kurumi-2508Right knee but the wrong mbappe 😭😭😭 holy fuck man342
u/LilPookie95238
u/Kalpesh_Knahh this one is hilarious 😭109
u/loadedhunter3003This is genuinely the funniest thing I've seen hahaha93
u/Teknas9364
u/Bra1n-3aterKnowing how they work they might aswell do this fr49
u/kamleshsulochanHow bro felt after posting the top post of soccercirclejerk41
u/SirMervin39
u/MoreanSwordsmanBut was it the right Mbappe?27
u/sBand6032The situation's so wild you just gotta laugh at this point. Idk what our doctors were smoking that day, but that must have been sth strong 😂16
u/Complexion-11
u/Valveringham85Good meme 👌10
u/madbunny89Good one, bro! I laughed ( which is so rare on this sub ) and I also saved it. Thanks for the good vibes!4
u/jipsjipslmao it never stops3
u/Aggravating_Owl_69953
u/Ch1va5The right knee, but not Mbappé's - third time's the charm 🤷‍♂️3
u/Neither_Log1046Damn that's funny af2
u/asakuranagato😂1
u/syam03😭1
u/Solari6This shit is too funny ahahaha1
u/Inevitable_Spend_102This is hilarious 😂, I'm sure kylian will be laughing so hard when he sees this 😂😂.1
u/DailysPicksYou only have one job1
u/Shaun_the_sheep999🙂🤣🤣🤣🤣1
u/Kuttoosan47Fucking hell😂😂1
u/Animatrix_MakOut jerked by r/realmadrid post incoming on r/soccercirclejerk1
u/kuul_exegame's gone1
u/TheKingPin16Lmaoo made me spit out my coke1
u/yvettt921
u/Outrageous_Tax1328
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99r/mattxivharry potter isn’t real, but you are. happy trans day of visibility ♥️ConcernedJobCoach5050%1064.0PRP knee treatment2026-03-31↗
commentercommentsentimentupvotes
u/kyriaki42Unironically, looking at these statistics is what convinced me to finally take the plunge, ignore all the gaslighting and get top surgery. I knew I wanted it, knew it would make my life so much more livable, but had a lifetime of people telling me I didn't know what was good for me. Best decision I ever made.21
u/Jenderflux-ScFiI forgot the regret rate for Harry Potter tattoos, but it is higher than the overall regret rate for tattoos. I love all my trans sisters, brothers, and siblings 🏳️‍⚧️🩵🩷🤍🩷🩵🏳️‍⚧️18
u/JaebberishTrans rights should never be compromised, it’s all or nothing. Making a compromise on trans rights, is like making a compromise on how many hostages a kidnapper should get to keep. All people are equal. Everyone deserves rights. “Normal” is inherently subjective. End of discussion.8
u/snertwith2lsI support trans rights and the rights of all people to decide what it means to live their best life. I admit the idea of surgery really makes me queasy so I figure if someone decides to go ahead with surgery, especially now knowing there's such a phenomenally low regret rate, then they must be totally committed and I absolutely support them in their decision. Edit to add thank you so much for this post!6
u/demon_twink_gockieSeconded. Any law restricting trans folks must be defied at every step. It is not enough merely to demand freedom from the oppressor. Freedom must be TAKEN from the oppressor.2
u/retrofrenchtoastWhy do people regret knee replacement and corrective spinal surgery? Do they make things worse so frequently?1
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100r/eagles[Berman] Landon Dickerson went to Medellin, Colombia, to undergo stem cell thera...indig0sixalpha4750%8363.7stem cell therapy2026-03-09↗
commentercommentsentimentupvotes
u/burratnaExciting Whites and the Stem Cell Boys268
u/jawadali415Can we send Embiid there248
u/Alive_Bodybuilder288I am Queens Boulevard84
u/bkist267Columbian stem cell therapy is so hot right now66
u/HyrogrifixNeither guy looked right last year, them Being healthy this year is more important than signing anyone in free agency44
u/mb0205OL was playing crippled last year Jesus Christ lol20
u/larson00I didn't know this was even a thing17
u/wire28Our fate is in your hands, Colombia10
u/HotSaucePalmTreeslol the US healthcare system is a fucking joke10
u/Spare-Half796Columbia is heaven for large strong men who have joint problems8
u/IllbloodHope I can get stem cell therapy for my back pain one day. If only we gave a shit about medical research in this country, who knows what else could be done with stem cells.8
u/Overall-Specialist37My purpose of travel to Medellin? <squints at sweaty crib notes on palm of hand> uhh umm stew celery theory7
u/huck_I guess Cam Jurgens was the guinea pig.5
u/Competitive-Umpire18“Stem cells”5
u/baconcheesytots_They just going for the Colombian girls with fat asses5
u/ZhangtheGreatI think a lot of us knew they weren’t healthy last season. Hopefully, we’ve fixed our major OL woes now.4
u/Responsible-Fix9684[deleted]4
u/rodrigoa1990What is his injury, specifically? I know it's his knee, but like, ligament, meniscus? And why is it lingering so much3
u/Onlypaws_I’m sure the blow helped, too.3
u/scottylightningHis Uncrustables are stem cell filled2
u/doughball27having worked with researchers who are studying this stuff, there is absolutely no evidence yet that stem cell therapies work. this is just really expensive snake oil, unfortunately. the fact that he had to go to columbia to pursue this should be all you need to know about its efficacy.1
u/CardiffGiant7117lol drug test inbound1
u/Forsaken_Crow_7707As long as the stem cell boys didn’t pick up any nose candy habit while in town1
u/redditzaneIsn't Medellin where Escobar was based?1
u/gimmethatfiletofishThis will be worth it when we get a highlight reel of Jurgens and Dickerson pancaking defenders set to the theme song from Narcos1
u/MathRockEnjoyer420Nah our O line is still gonna be cooked lol1
u/WhyDoTheyAlwaysRun"Stem cell therapy"1
u/phillabadboy05I would imagine this would be pretty successful for the average person who's body isn't pounded every week. I wonder how long it could effective for a professional athlete1
u/PA_MallowPrincess_98Philadelphia Eagles 🤝 Philadelphia Phillies Finding new ways to heal injuries1
u/osirus35You always hear praises of stem cells but like is there a recovery timeline where the healing from the stem cells is most effective? Like will they be 90% this year vs 50% last year.1
u/MyKidsArentOnRedditAnyone with some actual knowledge want to chime in? Is this therapy real or is it a bunch of BS? If the former, why is it not offered in the US?1
u/mmuoioGod I hope it works, we need them both playing better.1
u/AC_deuceyGuess they both love medellin with stem cells Rest of the league like “we would have sacked Jalen if it weren’t for those Medellin kids!” That’s all I got, I’m out1
u/Different_Inside_546There both cooked…1
u/Ill-CommsOLINE heavy draft incoming.1
u/weezyverseA reminder that cocaine is all natural.1
u/Aerolithe_LionWhy of all times of the year are you breaking this right now1
u/burnernov2023Please go easy on the tush pushes this year Nick.1
u/Drewraven10Should’ve did it after the Super Bowl tbh1
u/phthalo-starMom get in here, the whites are getting ready to be exciting again!1
u/phillabadboy05I would imagine this would be pretty successful for the average person who's body isn't pounded every week. I wonder how long it could effective for a professional athlete
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101r/ValueInvesting$SLS Part 2 and FINAL (Deepest Due Diligence for REGAL Trial) (Results from Mach...Confident-Web-7118300%2963.2stem cell therapy2026-03-08↗
commentercommentsentimentupvotes
u/Accurate_Pay_2242Love SLS10
u/Confident-Web-7118Thanks for this. I’ve previously read both parts of your analysis and tried to stress test it myself. Not having biostatistics expertise this has been hard to do. I began to think about other ways to prove the trial is working through looking at other evidence (investigator testimonials, clinical supply and logistics, etc). Did not find anything to contradict your conclusion Have you looked at any of these avenues? Any new thoughts or evidence since you did your analysis a while back?7
u/Remarkable-Big-9849Hello, We discussed things a few days ago on one of these threads and I've spent the last week doing even more testing and wanted to update you since a few things you said inspired me a bit. First you mentioned I was using an agnostic 50% prior and that a literature-informed prior would be closer to70% with a pessimistic prior at 20%. While I agree that if we take overall oncology phase-3 trial success rates and the biological mechanistic plausibility, it would imply around 70% as a reasonable prior but vaccines and immunotherapies like this especially in diseases like AML have had much lower success rates so I actually think a 20-40% prior is more supported with the 40% being driven by the phase-2 evidence and biological plausibility. Second, you mentioned that you looked at what the failures actually looked like and that inspired me to look into the failures myself and other trial data where the trial was a statistical miss but the biological signal was strong enough that another trial happened. Using those conditions, I was able to separate out failures where the drug works but failed due to statistical power and another trial happens. Combining that with the prior range I mentioned earlier, I got the following scenario probabilities: Final derived scenario probabilities Scenario Probability Strong success (cure tail) 70-85% Moderate success 8–15% Statistical miss but signal 3–6% No effect 1–2% which actually brings me a bit in more line with your reproduction of my methodology where you got 98-99% chance the drug works. I do think we should treat the statistical miss scenario as a 50% value haircut due to extending the timeline out a few years and increasing early costs (which may or may not increase dilution, as they do have a lot of cash) I also wanted to share a histogram I produced in my initial testing for the probabilistic feasible region for cure fraction but reddit doesn't let me post images in a comment it seems. So here is some of the data: Number of feasible draws: 50000 Mean implied cure fraction: 0.578 Median implied cure fraction: 0.590 Probability cure fraction >= 0.20: 1.000 5th, 10th, 25th Percentiles: [0.39379246 0.43575868 0.51072057] Probability of Cure Fraction above 35%: 0.9784 Talking about the economics a bit: Revenue=N*Penetration*Price*Duration and we know that a cure fraction is going to increase both Duration and effective N over time as patients stay alive longer so if the average treatment duration without cure is represented by D and cured patients that stay treated by kD, we have: Duration=(1−p)D+p(kD) =D[1+p(k−1)]= D[1 + p(k-1)]=D[1+p(k−1)]=1+p(k−1) where k represents how much longer the patients stay treated and p is the cure fraction. If the baseline therapy duration is ~12 months and durable responders last 3-5 years on the treatment, we would have a revenue model of 1 +2p to 1 +4p and if an acceptable cost per quality life-year gained is ~$100-150k in the USA then we could have a 2-3.5x revenue effect over baseline (current population) based on my histogram data. If the drug is extremely effective and adds 10-20 life years then the total price might be limited due to payer pressure so I didn't want to model that out.5
u/Limp_Leg3323Really appreciate the insights you shared here! Stress testing can feel like trying to solve a Rubik’s cube blindfolded, right? I’d love to hear if you’ve unearthed any fresh evidence or thoughts since your analysis!5
u/Adeus_AtticusI’ve already thanked you for this but will do so again! Do you see the basement value rising the longer REGAL goes on?3
u/hariharsharmaJust curious on 2 things: I don't see any disclaimer on this post, is it sponsored? don't get offended please. Just curious. how far the stock will go if the result is positive as the model/analysis indicates most important, how likely SLS will release more stocks during up coming meeting in 2 weeks, like they did in early January 2026 taking benefit of higher market price. Thanks for reading and responding my comment.
u/Ok_Choice_3228I evwn got bored of scrolling. I can't imagine anyone has a whole free day to read all of this...-6
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102r/Hairtransplantday 3 post OP absolute hair , doctor R.Enough-Bother6932270%3363.2stem cell therapy2026-03-13↗
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u/ThemeAppropriate575Hello bro, that looks amazing, do you have pictures of the sides and back before HT please? Your case very interesting because I think we are very similar, thanks5
u/JohnMcCainsCapturersvery interesting case and would love to see how it looks like at around month 7 onwards, i hope you wont have to come for a 2nd time!4
u/Forever778That looks amazing. How long was the procedure? How much does Dr R do? What was the cost? And was it easy to go out travel after? Thank you!2
u/Ok-North10Dr Ratchatborn?2
u/markiemark6I’m on day 3 as well.. and this healing process is rough. I swelled a good bit and my donor area aches pretty good.. how’s your experience been so far?2
u/Enough-Bother6932<image> day 6 back in us after long flight ✈️ today2
u/go_get_your_hyungThank you for posting!! I’m booked with her too! Albeit, a long time from now. Questions: What is her HBOT price for the 3 sessions? Just trying to get a ballpark idea. Do you do HBOT in morning —>rest—> LLLT in the afternoons and if not, how does the sequence go? I see you are only staying 6 days post-op and realize you will not be taking advantage of it, but did you see if they offered a service to remove scabs between day 10-14? I have seen some clinics offer an olive oil treatment for that; regardless of how they do it i’m terrified of doing it myself so was hoping they could. I’ve been through all her pre-op and post-op instructions. Anything you have learned more or would do differently if you had to repeat? Is a neck pillow enough, or would you bring an inflatable wedge pillow too?1
u/Enough-Bother6932<image> Day 5 post op after last wash and llt at absolute . bittersweet leaving tomorrow, as id love to stay till scaps come off . They take such good care of you . If you can stay for 10 days post id recommend so you dont have to do it yourself , but also they have given me the tools and knowledge i need to perform the rest of the care1
u/Enough-Bother6932<image> donor day 5 post op1
u/Enough-Bother6932<image> Day 8 POST OP back in US as of yesterday1
u/Enough-Bother6932<image> Day 8 donor area1
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103r/VAClaimsIncrease claim denied as “not service connected” - makes no sense?Any_Let5221130%7662.7PRP knee treatment2026-03-22↗
commentercommentsentimentupvotes
u/Creative_Raise_8682Not attending the c&p was not thr right move. If they schedule another one, show up for it.39
u/Gatesofhell2120You still have to go to the VA exam. Technically speaking you can choose not to go, but if you don't they are going to deny you. It doesn't matter whether you have private DBQs or not or what the claim is for, you still need to go to a scheduled C&P exam. After the exams the VA MIGHT look into your DBQs. I don't know who told you you don't need to attend the VA's exam or why, but they fucked you over if you listened.34
u/Quirky_Republic_3454For openers, Ree medical is not VA approved. Secondly, missing the VAs C&P exam was a huge no-no. How many mistakes can you make on one claim? Go find a VSO. You have no idea what you're doing.14
u/Lennydawg57You should have went to the schedule C&P,13
u/Caliente_La_FleurIf you are scheduled for C&p for increase and you don’t attend it is an automatic denial, per M-21.13
u/97lifeAttend VA C&Ps. For heaven’s sakes. The sheer foolishness9
u/Wesley832Look on the bright side, Doug Collins says there's no back log.7
u/Majestic_Try906I just don’t understand not going because you submitted private DBQs. No matter what you submit, if they schedule you, then you should be going. They usually want to make sure that the information is accurate. Not really a smart move, in my opinion.6
u/Big-Hovercraft1331Post the decision narrative with PII and QR codes redacted.5
u/Big-Hovercraft1331My suspicion is the rater went to do blanket denials for the increases due to you refusing the exams and used the wrong narrative. You can do an HLR due to the decision being for service connection and not for increase and ask the reviewer why they found your DBQs to be insufficient. You believe they were sufficient. If the reviewer still finds your DBQs insufficient, you didn't attend the exam then at best an HLR will correct the narrative.5
u/WithHeavenOnTopWhy would you miss the C&P….they are literally trying to help you.5
u/Admirable_Hedgehog64[deleted]4
u/GulfWarVeteran1991What do the folks that told you not to go to the c and p exam have to say about this?4
u/Emotional_Childhood6😬……they told you not to go to your C&P………😬3
u/DealerofTheWorldLol can I know how much you paid for this amazing advice3
u/Big-Hovercraft1331Did you physically meet with a REE medical examiner?2
u/nawlforealIts also very unusual to deny two conditions in one issue. In this case left knee and cervical spine. It makes .e wonder what the Rater did because if you are already service connected the decision process for building the decision is different and this would be easier and faster to deny an increase than a claim for service connection. I would request a HLR. I am assuming only two of rhe conditions are service connected since you at at 20%.2
u/Creative_Raise_8682Not attending the c&p was not thr right move. If they schedule another one, show up for it.2
u/SharingKnowledgeHopeSounds like they answered the wrong question: “Is this serviced connected?” Unfortunately happens a lot with the first level review. Request a higher level review, with a telephone discussion. You can explain it to them, they will straighten it out.2
u/kev_mimsTo deny a C&P is probably not the best choice... REE is definitely on the VA watchlist. Cease-and-Desist Directives: The VA's Office of General Counsel has previously directed REE Medical to "immediately cease" activities that the VA considers unauthorized or illegal representation under federal law.2
u/Brilliant-Flight5314Yall get bad advice always attend exams regardless2
u/Lennydawg57People are always trying to use other faculties that are scammers that only want money and bad advice. I hope it works out for you but I don’t think it will.1
u/WishSuperb1427Well, I have never heard of REE medical, so I will not vote on if that is a good idea compared to a VA certified attorney or a VSO. On to the second part of the question though…. which honestly may lead back to the question of who REE medical is and what they do… Why again would you skip a C&P exam?!? It’s kind of a thing where a medical person hired by the VA confirms that what you are claiming is an actual medical issue…. Seems to me like a thing you might be will to miss a tee time or a business lunch for but um?!?! Yeah I am not surprised skipping it was a contributing factor to denial.1
u/FirmCarry1931Baby just file again.1
u/Successful_Pea_2528Ok, you filed a claim for increase on these conditions and we denied service connection? Did you claim new issues with the increase?1
u/Careless_Distance557You guys need to realize....not going to an Exam is a risk that you should not be willing to take..it doesn't matter if you have private medical opinion or DBQ...go to the exam.1
u/No-Survey-569Never miss a C&P, and sorry don't pay for claim sharks. If you pay for representation be sure they are a VA accredited attorney or claims officer.1
u/OofUghGenuinely so confused about why you didn’t attend your C&P exam? Private DBQs are purely supplemental.1
u/Educational-Star-375Always go to the exam the Va schedules for you. You got scammed brother1
u/Medical_Barnacle_240Just to clarify, “REE Medical” filed an increase request for you and on your behalf? If the answer is yes, then they - REE Medical - are the ones who screwed the pooch. My advice to you would be to contact a VSO through your local VA hospital and/or your county VSO (assuming you have one). Third parties always make this look easy, but they do so to enrich themselves at your expense. Never trust them.1
u/Excellent_Cupcake749Stop using outside entities for dbqs. Use the dbqs you are given appointments for. The more you poke the VA the less likely you are to receive the compensation you deserve. You did it to yourself. I went from 20%-90% by myself and only going to the c&p exams appointed by the Va not outside sources1
u/ScoeDaKidd6767go HLR1
u/New-Courage-7052F you and anyone who uses those 3rd party companies
u/Willing-Persimmon401Contact me, let's get you paid. Anyone else, contact me, it's time for a real change.-7
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104r/sellaslifesciencesNew Sterg Postmad_papooser890%6162.4stem cell therapy2026-03-06↗
commentercommentsentimentupvotes
u/United-Collar-944He doesn't actually talk much about the REGAL result itself. Instead, he talks several times about what happens after REGAL – new indications, platform thinking around GPS and the broader WT1 track. This seems to be a pattern in his communication on LinkedInpost the last month or two: REGAL is not presented as a single binary event, but more as a first step if the data holds up. Maybe I'm overinterpreting, but it's interesting that the focus several times is on post-REGAL strategy, not just the study.26
u/CaptainWhiplashMy man Sterg ain't mincing words talking about "curative". Fellas, this is bullish af23
u/mad_papooserSomething that is being overlooked is that while Sterg and SELLAS may be technically blinded to the patients, they know 100% real time if GPS is working. They are managing the supply chain!! The know every vial that gets ordered by every testing center. Real time. They know if patients are living longer based on live order volume at each center.20
u/mad_papooserOr…bulls on parade :) Anyone notice that word “curative” in there? He’s dropping breadcrumbs to us. This thing is hitting.20
u/TemporumdeiPerfect timing.14
u/ShawnniegUAn<image> What is this statement. No more maintenance but cure???12
u/Desperate_Work_7742In the movie business, these are called “Easter eggs”. Very encouraging and I think there would be ZERO of these types of updates if things were trending in the wrong direction. I remain VERY BULLISH on a binary event and hopefully and meaningful buy out 🔥🔥🔥11
u/neo2551At least, he seems bullish on his assets.9
u/Such-Leg4898I like it............ but ........... to be honest I don't think he would write it while in the middle of buyout negotiations. Therefore I don't think we are that close to an announcement. I'm super bullish but that's how I view it.7
u/Prestigious_Age5422Guys, do you know how risky it would be to post this frequent of content and the nature of this content unless…. 🙏🏻7
u/nicklank4This is huge!! FOMO will kick in today and take the stock over $66
u/United-Collar-944<image> 👏👏👏3
u/bsep4Are analysts PTs assuming BO? I’m curious how much a BP might offer knowing they’d have to pay royalties to MSK.3
u/Ramuh321Which is plenty of time to read all the DD, watch the Oct call, and come up with a reasonable guess on valuation. Not sure what your point is.1
u/SilverFoxSixNo photo?-2
u/Julbas01After thats words i'd say Sterg is in love with Sellas. I have the impression that he would like to retain Sellas and would prefer to enter into a partnership with BP. Or sell only 50%, so that he can keep Sellas as his own venture.-3
u/Remarkable-Apricot77bro is fishing for the BO-6
u/Old-Smile785They should team up with $IBRX !!-7
u/InfiniteChallenge981he is a desperate man-30
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105r/antinatalismBrain Farming is no longer sci-fiPomegranateLost1085430%1362.2induced pluripotent stem cells2026-03-19↗
commentercommentsentimentupvotes
u/SunOverGravesIt is unethical experimentation. I am excited by science and scientific discovery, however I do believe people should push more health research and new sustainable energy. This bullshit is some "I have no mouth and I must scream" type of experimentation.negative9
u/akhattenEven worse, they managed to replicare the entire brain of a fly and put it into a simulated environment and body. We are speedrunning to altered carbonpositive8
u/CapedCapererThank you for the great post. I think bio-data centers sound like a scam for securing funding from venture capitalists. It's definitely unethical. I see they are trying to wrap this scam in greenwashing which is another tell that the promised technology will be undeliverable. So far they have only managed to create chips that lose at playing DOOM. Just in case, not reproducing and cremation are my defense systems.negative5
u/RiverOddDo you want AM? Because this is how you get AM. ?positive2
u/Eldarkshine08Cruelty squad ☠️negative2
u/AutoModeratorRule breakers will be reincarnated: No violence, coercion, harm No pro-suicide content No personal info / doxxing No harassment / bigotry No hate ideologies No eugenics / gatekeeping No sexism No speciesism No memes on weekdays (UTC) No bait or sealioning Stay on-topic Rants belong in Megathread Quality & sourcing Screenshots must be redacted 15. Moderator discretion I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral1
u/Low-Scallion8793This is SO unethical tbhnegative1
u/Aquarius52216Well morals were always in the furthest back or not even in the equation for these ghouls after all. Who the hell cares if we are inventing a literal comically cruel agony matrix if it help nett us 2% growth on the next quarter revenue right?negative1
u/ZwsgvbhmkOkay so I ain't no scientist but I believe it takes more than a few cells on a chip to have a fully concious mind. Our brains are huge and we use a pretty large part of it for everything that makes us "us". There's way more animals that don't have a concept of "self" than there are who do. I think it's very unlikely that we could create something that's concious on such a small scale and it's even less likely that it would be self aware and it's pretty much impossible that it could ever have concepts like "Oh got I'm trapped in have no body i have no mouth". So yeah this probably won't turn into man made horrors beyond human comprehension.neutral1
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106r/ICSELata and her f*cking potatosNo-Couple2071390%1562.2induced pluripotent stem cells2026-03-12↗
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u/Majestic-Variety3348NOT RAGEBAITING, but can you tell me what was so hard about that potato question? I personally found the question paper quite difficult and messed up some questions myself, but the potato question was pretty simple and straightforward and probably one of the easiest questions in the entire paper. I genuinely wanna know why everyone finds that question difficult ?neutral15
u/Substantial-Bid-9934Exam khatam nahi hue kya?? ( 99 in bio btw ) ?neutral1
u/AutoModeratorHello /u/No-Couple2071 , welcome to r/ICSE! Join the official discord server! Before posting, please check the wiki. It contains resources, advice posts and general support posts that many users have found useful. We had an advice megathread where users posted their words of wisdom for the juniors, Do check it out If you have any questions, you can contact the moderators via mod-mail. Thank you! I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral
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107r/PeterAttiaLongevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran300%2162.2regenerative medicine2026-03-22↗
commentercommentsentimentupvotes
u/Own-Bullfrog7803Im sorry, there is no “real” board certification (American board of medical specialties) for anti-aging and regeneration. It appears to be a certificate program by a society.13
u/Earesth99I tend to question people with board certifications from Scooby Do snd friends. It’s almost as bad as being a board certified homeopathic doctor. Or a doctor of naturopathy. Hence his non-evidence based ApoB recommendations. And his ignorance of the half lives of atorvastatin and Rosuvastatin.5
u/accuracy_101Why not pitavastatin?3
u/SillyEffective4700What’s your exercise protocol? How concerning is resistance/bodybuilding-style training whilst on statins (rhabdo risk)?2
u/SFL_27Can you give the reference for "The statin evidence for APOE4 carriers"1
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108r/decayingwinterThe Ideology Of the Reikkgon Cultists Explained( fanmade expansion theory)Embarrassed_Name266180%3962.0regenerative medicine2026-03-04↗
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u/Delta_75now where did i see this picture before? <image>5
u/Punman_69hey buddy. ever heard of “crediting the original creator”? edit: you spelled reikgon wrong dumbass3
u/NotZealoussReigkon is a god and SIN worships him, the shadows are people very devoted to him (or it.)2
u/SpacedWasTakenMy personal headcanon surrounding the Reikgon faction and its cultists is that the Reikgon are an alien species originating from the planet Ossis-666. This race basically exists with the sole goal to expand, colonize, and assimilate other worlds and lifeforms into a singular, vast collective hive network. In their base, pure form, the Reikgon resemble small parasitic organisms that burrow into the minds of their hosts. From there, they gradually overwrite both mind and body, reshaping the host into a living embodiment of their deepest fears, emotions, or desires. Hangers represent misery; Hiddens embody athazagoraphobia (the fear of being forgotten); Sicklers reflect psychosis, mania, and wrath; and Skinners manifest depersonalization. The cultists act as fanatical followers to the Reikgon’s doctrine, acting as a transitional stage before full conversion into the monstrous forms encountered later. They are not yet fully overtaken, but are no longer entirely human. A select few, such as Acolytes, Cultist Leaders, and High Priests, are able to discipline their minds and establish a form of symbiosis with their Reikgon parasite. Rather than being consumed outright, they weaponize their amplified emotions and desires, turning them into instruments of violence against others. The reason the Reikgon remain a minor faction within the broader violent ecosystem of Eden-227 is that they established a forward operating base on the planet long before human colonization. However, the planet’s extreme and unforgiving climate eventually froze the base and its inhabitants in stasis. They were only reawakened during humanity’s later colonization efforts, emerging once more during the chaos of the Collapse
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109r/NovoNordisk_StockJust in: Ozempic and Wegovy found to unlock blood vessels during heart attacks. ...kiyomoris560%861.7regenerative medicine2026-03-03↗
commentercommentsentimentupvotes
u/HalfInside3167Good, tomorrow NVO -5%14
u/CommercialFit9730Man all this good news are amazing,but we are on 5 years low and every day is going a new low. It is devastating.13
u/About_to_kmsGreat news. -5%1
u/Boring-Ad-3955Great news -5%1
u/Weekly_Writing7200This is getting comical. What next, ozempic cures cancer? Maybe cures alzheimer will we’re at it?1
u/Donnahue-GeorgeTon of cope in this subreddit recently1
u/Otherwise-Review-712stock to expensive, can’t afford it, might nibble a little at 20$-1
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110r/catquestionsSevere anemia in young cat – bone marrow biopsy decision (looking for experience...MaplexMochi760%561.6regenerative medicine2026-03-18↗
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u/later-g8rI have no advice but I truly hope your kitty is okay. Id do anything for my babies. Dont give up. ❤️ we're here with you if you need anything.1
u/atotalwakingupBoost for support and advice ❤️‍🩹1
u/MaplexMochiWe decided to skip the biopsy and go straight to steroid treatment to not put her through it, as it was unlikely to be an infection. We received the tests back for full panel infections and they were negative. Now everything is ruled out except Immune-mediated bone marrow disease (treatable with steroids), leukemia in bone marrow or aplasia (poor quality of life). We decided to take a leap of faith with steroids (prednisolone). Day 4 and she’s had great energy, eating, drinking, playful, and affectionate! Her PCV as fluctuated around 9 - 15% since the first, but unfortunately during her check up today she dipped to 12% from 14% a few days ago. We opted for her 4th blood transfusion and to start cyclosporine. Our next check up is on Tuesday, and hope to see a good response to the meds. This feels like our last Hail Mary and hoping for the best, but prepared for the worst. It’s been the toughest week of my life, besides almost losing my dad to COVID, while work has been a shit show. Worked til 9pm on a Friday and had to work til 8pm on a Saturday when I’m supposed to have weekends off 😩. Needless to say it’s been super overwhelming and just wanting to have quality time with my cat. I also worry how her sibling will manage. When she’s been hospitalized he’s been meowing endlessly searching for her and it breaks my heart. Anywho - that’s my update and hope Tuesday brings good news. Looking forward to loving up on Maple and cherishing every moment with her. Thanks for your support.1
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111r/MAFS_AUAlissa's treatment of David - a racial element?kocknocker1980%12861.5PRP knee treatment2026-03-30↗
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u/Fragrant_Try_8060Alissa wants David to crash out, not because of his skin color, but because she needs a certain level of combativeness is her relationship. That’s what makes a ‘man’ to her. David not rising to the bait is why makes him less of a man, in her head a real man would never let her bulldoze him the way she does with David. What becomes an issue and where it does become a racism thing, is her as a white woman not understanding or even being aware of the position she is putting him in and why that’s not okay. David said his calm demeanor was an intentional choice he made before coming on the show, and one can only assume it’s so he wouldn’t be portrayed as an aggressive or angry black man on national television. Alissa is a stellar example of a white woman who sees herself as non racist and better than that, but she hasn’t actually done the internal work to recognize that dynamic there in an interracial relationship, and she very likely hasn’t deconstructed a lot of the subtle and internalized racism that comes along with living in a society that is run by and for white people. It’s not enough to say you’re not a racist, you have to put in a conscious energy into proving and cultivating a space in your day to day that is safe for people of color, and that is not what we have seen from Alissa34
u/aaidpIt made me uncomfortable her saying he was weak etc, almost like she was baiting him to become aggressive and fall into the stereotype. But I suspect she’s just so self absorbed and clueless she hasn’t even thought about it that way. The way she keeps describing herself as “loud” in a way that’s positive is a dead giveaway. Sure, society rewards extroversion but she doesn’t realise shes bloody annoying.29
u/CamillaBarkaBowlesSome people (ADHD mainly) get dopamine from conflict. And David gives no conflict and Alissa gets no dopamine. here is the link26
u/friedonionscentI don't know...what I do know is that she's incredibly annoying...the type who thinks she's the spark in the room...when all she does is suck the ambiance and replace it with her chaotic, self-stroking energy. She's performative and doesn't have a nice vibe at all.23
u/anastasia_42I feel like this is looking for racism where there isn't any. But I have to say ever since Alissa made him kneel at the wedding you could tell why she was single.22
u/Peacock_chopra-8098I'm American and I learned when I was very young that you don't call Black men "boys." It has a racist history. Her comments to David have made me uncomfortable, like when she said "He thick" -- like, please stop! I think she would have likely mistreated a white guy but I do think there are racial undertones to some of her mistreatment of him.22
u/Top_Effect5135I don’t think it’s a race thing, I think it’s a “she’s a nightmare” thing. Why is Gia so vile to Scott? Because she’s a nasty cow, that’s why.20
u/-Mantaforce-No, she’s just a massive bell end19
u/SapphireColouredEyesLike everywhere in the world, Australia has some racist people too, but calling black men "boy" is such an American thing, soo no, I don't think it was the least but racist, and was in fact quite affectionate. Lots of people call men "boys", and it's just affectionate.  The making her groom kneel down before the marriage was planned ahead of time, and she did not know he would be black, so your friend will have to try harder to find racism in a relationship where there wasn't any.18
u/justrachxoI think she planned the "get down on one knee" thing in her head well before she even knew who she was marrying, so no, I dont think that has a racial element to it. I did like her until David met with bec and she was upset that the screen shots were brought up. The way she spoke over him and didnt hear what he was trying to say was obnoxious. Since then, I think we can just see that she is hard work and thinks shes better than everyone else. With the travelling the world bs that she kept mentioning and "success".18
u/verytallericI thought the core issue is simply that she feels superior to him. Is race part of that? Dunno, maybe. What I think is comical is that I see him as a much higher quality person to her. She's lucky to have him, not the other way around. He's better to dump her17
u/Marlene21xI have been thinking the SAME! But I’ve been too nervous to bring it up! I listen to a lot of live discussion panels on TikTok related to race and interracial rships in America, and there’s always a lot of talk about white privileged women with black men, and how they treat them as less than, even on a subconscious level - and how the black men in those rships have to always be extra cautious because of the racial bias the police have towards black men or society itself in general has… I have wondered if this is why David has been much more cautious of how he comes across, and why Alissa feels she can get away with several of her behaviours. I felt such unease when she commanded him to kneel, or how she ordered him to carry the cheese platter to the table, or when she was abusing him when she couldnt feel comfortable sleeping at the retreat — it all just felt like some sort of master/servant rship 🫤 But I would love to hear how this has been viewed by other black ppl — if they have seen these undertones or we’re reading into this deeper than what it’s been?17
u/choiboi29She is so self absorbed. She tells David he is weak and needs to speak up. He tries to talk only for her to continue to talk over him.... It's so frustrating to watch him try to get a word in, only to get shut down and then she closes it off by going "ugh I'm so tired of doing everything" 🙄 She must have got a really good edit cos we're starting to see the reason why her mother even says she is 'too much" at times16
u/ScumhookDo you think she would be like this if the guy were white? Yes. I initially thought she was an obnoxious twat. I then softened my stance when they all piled on her, and thought she handled it well. Now I'm back to the OT assessment.15
u/brgr77As a Black american, there's no way you can have this conversation in this forum lol. They'll act like they dont know what youre talking about Just know we're talking about it over here and have been since the premiere14
u/TwoToneMoonstone_Probably not intentionally. I think Alissa would have been patronizing to all of her partners it just hits the ear wrong because David happens to be black.14
u/Lanky-Conclusion-952“Talk to me” while talking over him!14
u/sickiesusanI felt the whole wedding ceremony was uncomfortable because of this. Would she have done the same with a white man, we will never know. But I also don’t like her using the word ‘boy’, it just doesn’t sound respectful.13
u/Bubbly_Status_9112Yeah I clocked this too. But more in the way of how she'd speak in a blaccent to him 💀 "This ma husband, girl!" Etc13
u/SweetTalkRiverNo, I don't think it's about race. It's about her wildly inflated opinion of herself. Any guy would go through hell with her11
u/Healing-and-HappyShe calls herself a girl, so I don’t think her calling him a boy means anything derogatory for her.11
u/mustxproteccalso in the beginning when she kept going on about finding her nigerian prince and made all these sexual jokes about him based on his race it just felt a little icky…10
u/oceangal2018If there are guys on this chat please know that not all women behave this way. We just don’t. These women are all a little unhinged.10
u/Junglerumble19I think you're reaching. She'd planned that stunt at the wedding no matter who was at the other end.8
u/Fantastic_Ad7023I don’t think it has anything to do with race tbh. I think she is somewhat pretentious (money wise) and very high maintenance. That stunt was pre planned so would have happened no matter who the groom was.8
u/SherylizeI feel like people say this way too quick once there is POC involved...8
u/Diligent-Ostrich-812The getting down on a knee would have happened no matter who she was with. She planned it. I don't think any of it is about race. As for using the word boy, some of my friends use that term and their "boys" are white. It is sort of a term of endearment to them, but in reality, I think they think their men are dumbasses, so when they are sayig it, it doesn't sound at all respectful to me. I think Alissa treats David like crap, but that is because I think she is a princess and thinks she is better than him and better than most people.7
u/jaidennabellShe tells him to speak up "babe", but every time he does she speaks over him and shuts him down. He says he wants a voice. She says use your voice babe.. And still shuts him right down7
u/qftvfuI think the only racial element is that David is doing his best to remain composed, and she's just walking all over him and not shutting up, shutting him down when he DOES speak up, then complaining he isn't opening up. I really want to understand what kind of conversation style she expects from someone, other than just listening and agreeing to her nonstop nonsense.7
u/Immediate_Put_9963I wouldn't say it is deliberately racist, but as a white women she should have more awareness of some of the things she says and makes him do. I think Alissa is quite self-centred generally, aswell as unaware of racial dynamics. Although, thinking about it some of her jokes do make me uncomfortable 'tall black' etc. I do kinda think it's a bit fetishizing. In saying all of this I do know from MAFS funny that David himself has some pretty disturbing/misogynist lyrics in his rap music and is friends with straight Chris (who is know to have violent tendencies) . I point this out not because it excuses Alissa's behaviour (because it doesn't) but because I don't want to feed into a narrative that the dynamic is as simple as Alissa - Persecutor/ David - Victim7
u/Loud_Reach_2156I guess you would have to ask David7
u/Swimming_Pass3603Nah. I don’t think so.7
u/romoladesloupsIt has made me uncomfortable at times, especially the kneeling. He seems to be enjoying it but her attitude to him comes over as fetishising6
u/finalgirlemilyI think she had that planned out regardless of his race. I can’t speak on her further behaviours after seeing how much they cut out of the show6
u/Background-Rabbit-84I think she had planned the get down on your knees thing regardless of race. However it becomes very relevant when the groom is black and she should have changed her plan the moment she saw him It’s more about her being clueless to racial issues than racism6
u/PlateFamous1793I gasp every time she calls him “boy”. Other than that, I don’t see any racist undertones but tbh that’s enough for me. But to be completely fair, these ppl aren’t well read, they’re not history buffs so she’s probably unaware of it, which potentially makes it worse idk. The lesson of the day is to stay in school and to read.5
u/mathking89No, I don't see how any of your reasons suggest she is being consciously or unconsciously racist at all. I think she'd judge any man/"boy" for not having as many assets as her, no matter their race. This is because this happens all the time between all kinds of people. If he was white, I think she'd be pointing the same criticisms at him.5
u/MinD_EroSioNWhen she calls him "boy", I've haven't heard it come across as racial, but given the times we're in, I think it's just an attack on his manhood. Which isn't any less of a red flag. Nothing like Bert Newton saying it toward Muhammad Ali at the Logies in '79 😆5
u/249592-82I suspect Alissa treats all men like this, and that is why she is still single, yet wants to have a family. I don't think David got special treatment. I do think they are not a match. And yet again, the producers put 2 people who are not a match together. He is Christian, she isn't. He lives in Bris, she is in Adelaide. She is loud and attention seeking, he is calm and thoughtful. All they have in common is: they both want to be famous, they both are hot, they both like the gym, they both live in Australia.4
u/craziestlittlepixieDavid had every right to call this out when it happened. Making a black person show submission to her, especially on a tv show 11% of Australians watch isn't at all ethical. If she had pre-planned this, then it should have been obvious to her not to go ahead when she saw David. But she's either naive and dumb as shit, or just a piece of shit4
u/Negative_Surround_12She's just participated for the AIR TIME....nothing else.3
u/Mother_Size_7898She just needs to stop talking for a minute and let David talk once in a while. I don’t think she means anything racially. A lot of women (me included) call men “Boys” all the time.2
u/Quirky-Knowledge4631Yes his race is a factor. He should have never bowed to her. That set the president to treat him as less then2
u/Spirited_RuinMusing into the void here, but I notice a few comments around this discussion stating that 'boy' isn't being used as a slur by Alissa because the term doesn't have the same connection to its use here in Aus that it might in the US. However, I think it's worth examining as a micro aggression because anybody with an internet connection may have picked up on its use from TikTok reels etc, and while they may be ignorant of the context, they're still using it in a way that causes harm?2
u/MelE5150We really didn’t get enough tape of them to be able to tell. But a few comments feel off to me about both of them. He seemed eager to play along and I get the vibe she is the type he wanted. Soooo <image>2
u/Beneficial-Koala-670We all know that when it comes to minorities, generally the experts are not going to match you with one unless that is what you specifically requested as your type. They usually are not going to risk it. I think that she probably would have treated any of hermatches like this. She's got that big girl boss energy which there's nothing wrong with that but she wants it both ways.1
u/Still_Cicada1472No. Not everything needs to get infected with American-style racial obsession. She's not an innately nasty person like Gia or Bec, but Alissa has revealed herself to be incredibly self-absorbed, selfish and high maintainence. Even during tonights episode, she was intercut saying that David is a good man, but he's the quiet, stoic type, while she needs a high energy personality to bounce off and constantly stimulate her. That sounds fucking exhausting to me, so I can see why she's still single. But race? No. I dated a half-black/half-white American woman, and when she called me "boy" she didn't do it with nasty racial connotations, it was just her style ("I struggled to find you on socials, I told my friend 'I cannot find this boy anywhere!!'" Etc).  Morgan Freeman said it best that if you want to reduce racism, then stop talking about it. Judge and hold people to the same standards and the immutable characteristics start to melt away.-4
u/wisperingdethNo.-4
u/PollyRRRRAww, and there was I thinking it was twoo wuv. I’m so disillusioned now, sob.-7
u/ilovebbcitvThere's a huge financial disparity between them. Alissa has created her brand and wealth, David has not. I beleive he works multiple jobs/gigs and rents his home. It depends how one defines success.-18
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112r/VeteransBenefitsUnconventional treatment options for knee issues. Any suggestions?jvn1983150%4261.4stem cell therapy2026-03-15↗
commentercommentsentimentupvotes
u/Common-Jackfruit-974Bpc 157 & tb 5007
u/ski2311Curcumin Physical therapy Tai chi Ice Recumbent bike Tylenol Viscosupplementation injections5
u/manokpsaThe VA in Hawaii hooked me up with a Thermazone unit and I'm really glad they did, because I've told my primary doc, orthopedist, and podiatrist that I've seen since moving to Texas that I have one with the knee and ankle/foot pads and they all have no idea what it is. I was trying to get my primary doc to put in for the head shaped pad for my migraines and she said that isn't something the VA does (WTF? They mailed the whole thing to me on Kauai, I'm sure they can send extra parts to Texas). It's just a little machine that pumps distilled water through some tubes into the pads, and you can alternate between hot and cold. It's my favorite thing. I also highly recommend Voltaren (Diclofenac Sodium). It's a topical NSAID. I have bulging discs in my back, osteoarthritis and bone spurs in my knees, and my podiatrist just told me I can use it for my heel pain. Works well for all three. The VA first started me on it while it was still prescription-only. My mom, who worked in a pain management clinic for 8 years, begged me to share it with her. Now you can buy it at Costco.3
u/Agree_T_DisagreeI’ve tried everything as well and actually was referred for acupuncture but no one has reached out yet. For reference I had a crush injury in my left ankle and it has permanent weakness and chronic pain. Hope you get the help you need.2
u/CandidDay3337Accupuncture, physical therapy2
u/Sea_Perspective8729Ask your provider for a mri or consultant to ortho and go that route. Xrays will tell you or show you if you have arthritis or whatever else. After that get a 2nd opinion and go from there2
u/Effective-Frosting38I get steroids & anti inflammatories injected into the 3 nerves on my knee caps.2
u/ikaw-nalangI'm thinking of trying it out a year of physical therapy ( with some shockwave and aqua) and traditional Thai medicine. Bangkok hospital offers some interesting packages and is familiar with the FMP program requirements. I have tried tons of things though. Tens machine, braces, acupuncture, physical therapy helped a ton but had diminishing returns.2
u/HonestOctoWhat a great post! I had my meniscus repaired in the military. My Dad and My Gram both had knee replacements. So, it's coming for me. Thanks for sharing.2
u/Chronic_Overthink3rI have suppartz injections every 6 months. They work well.2
u/Flat-Opening1068PT helps a lot..have them put you in for it… I just had mine last week and my doctor put me in for it for my back, knee and hand.. 🫡2
u/Ok-Cheek-5487Change in your diet, I was diagnosed with celiac and found out foods can cause inflammatory issues. Cinnamon can help with inflammation which can help with the muscle tissue around your joints.2
u/Fantastic_Day3076Stem cells in Mexico1
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113r/pennystocksModel to pre-screen potential multibaggersHefty_Vermicelli_802200%2661.1regenerative medicine2026-03-14↗
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u/passionlessDroneDon’t see SLS. Fake news?3
u/narayan77I expect RZLV will re-rate according to the model, if they can prove their projections by audited earnings.2
u/UnbrokenChillWould love to see PSSOF, HYLN, HYSR, and my current multi bagger HGRAF. Particularly interested in HGRAF and PSSOF. Appreciate your work. I'd love to see more of the model and how it works.2
u/Rochetechnology1Sound interesting2
u/HEK293INVAXwill be interesting to see if it catches the up and coming 10x baggers in oil production like EONR BRN YGRAF -unless you think $120 oil isn't going to be sticky.1
u/JCJENSON_Pr_Dept_6Would you mind providing links to the studies? I can't seem to find anything especially for the credit suisse study?1
u/trshmstrRequest for HGRAF, DRTS & CTM1
u/Digital_NarThe framework itself is interesting, but the reality is that most of those categories break down when you move into penny stock territory. The model was clearly inspired by studies on compounders and 100 baggers, which usually apply to quality growth companies, not microcaps in my humble opinion. That said have you experimented with compressing the model for small caps? For example focusing the score on a few key variables like capital structure, dilution risk, revenue acceleration, and catalyst density rather than the full framework. Could be interesting to see if the model behaves differently when applied to sub-$300M companies.1
u/EmbarrassedPart1256It's wild how $CAPS doesn't come up on anyone's scanners when it continually comes up on various ones I do, the same ones that I used to find $CTM @ $.18...🤔1
u/Responsible_Newt9644Neat. It’s a good idea. I’ve been looking at krakens success as a recent penny stock graduate and seeing where I can draw parallels in the penny stock I own. What if your model only uses recent penny stock graduates?1
u/StealthlessCTM two straight weeks of decline btw1
u/ScarShot587CTM is undervalued right now1
u/Horror-Pack-8319Great post - thanks for this1
u/PennyPumperDoes this submission fit our subreddit? If it does please upvote this comment. If it does not fit the subreddit please downvote this comment. I am a bot, and this comment was made automatically. Please contact us via modmail if you have any questions or concerns.
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114r/HypermobilityHypermobility is seriously ruining my happinesssarah_skribblez310%1461.0regenerative medicine2026-03-26↗
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u/Hype314Hi! This isn't a permanent fix, but it may help your pain in a matter of weeks AND improve your returns from physiotherapy. Please chat with your primary care physician about adding creatine to your daily diet. Creatine helps both with muscle strength AND with muscle fatigue. So much of hypermobile pain is due to muscles being massively overworked and not strong, but creatine can help both. Creatine is very well researched. Please read this article. You'll see incredible results -- this woman was so helped by the creatine that she was able to go back to work!!! Anecdotally, I have been struggling with so much pain and muscle soreness the last 3 years. I added creatine to my diet in December (5g / day) and my pain went from a daily 7/10 to a 3/10. I work out every day now. My physio has FINALLY started working (after 3 years!!!) and I'm more active than ever. Please chat with your doctor first and read up on the side effects (water weight / bloating for 4-6 weeks, after which it goes away) and increased thirst, but otherwise, I think it may help!!! Good luck ❤️20
u/Jealous-Ant-6197Same but I don't have any access to physio. Since you do, make sure the right muscles are being trained. Strength and stabilisation not stretching. Sauna, acupuncture and massages. Assistive tech like braces if you can afford them. If you have access to the resources, im sure you'll be okay, just takes mindfulness and consistency. If you dont have all the access you can ask get better, just takes a lot more effort. Im also 20 and it got bad enough to affect my studies and I had a bunch of emergency situations that got extremely bad. I wish I'd had more support coz i didn't know it could get this bad. It really sucks tbh, feels like a setback that could've been avoided but i had no control over7
u/star5stunnahHi! I am exactly the same. Even sleeping has been really uncomfortable for me. I cant stand for an hour or i already feel a lot of pain. Some days i feel like giving up but i just try to do the most in life. Things that keep me going are my loved ones, my passions, pets, hobbies. Its important you have a support system. Without that i wouldve been gone.3
u/busterbluth21So glad I found this sub. 39 yrs old and have osteoarthritis in almost all my joints bc of hypermobility. In constant pain. It sucks. And I feel like people don’t “believe” me2
u/caraneanWe shouldnt train a single muscle, it creates misalighment. We should train the who train of a muscle. Like squats, thats when u use the whole body. Also somatic movement helped me a lot, and smaller form of hanging, helped my neck and shoulders. I just grab my upper kitchen cabinet handle to stretch, i dont put weight on it. And i lay on the floor, move one arm up and move legs sideways, and then switch, and keep switching, it helps the chain of muscles2
u/IronDominionIf you are doing physio, you shouldn’t be getting weaker unless something else is going on, or you aren’t doing your exercises at home. Are you sure what you are experiencing doesn’t have another cause?1
u/star5stunnahAlso i smoke a lot lol that helps with the stress/pain1
u/Humble_Drag_6727Prolotherapy and PRP are great regenerative medicines for restrengthening ligaments, tendons, and muscle fibers.
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115r/CrohnsDiseaseWhat are some stuff that you find cool that science found for crohn'sZestyclose-Animal426250%1660.5regenerative medicine2026-04-01↗
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u/Due_Addendum_7844My son, 13, is taking part in a 1-2 year long study where they’re mapping him from diagnosis to treatment to hopefully remission. Studying his genetics, his food maps, labs, scopes and treatment protocols to try and figure out why some medications fail for some and work for others and how his genetics and diet play a role in everything. The research center he’s participating with is actually also mapping the genetics, diet and environmental links of a lot of major diseases, already following a group of new borns for their entire childhood and planning to eventually learn how to diagnose and reprogram these genes at birth and totally prevent kids from suffering at all from any major auto immune or other genetically linked disease or disorder. My son thinks it’s so cool he may get to be apart of maybe finding a preventative measure that keeps other kids, like maybe his own future kids, from going through what he’s dealing with. I just think of what I’ve read about what people diagnosed 20 years ago went through vs now and imagine when my son is a grown man how much things will have hopefully progressed for the better.12
u/antimodezWhile I'm excited it's also important to call out that things like CAR-T, let alone CAR-T without conditioning, are still at the early case report stage where we don't really know why certain one works but many others fail. I see people post random journal articles about mouse studies or a case report and not really understand how rarely these actually turn out successful later stage trials. They have just begun phase 1 trials so we're still in the extremely early stages here with not knowing how durable the response would be if you even get a response. Personally I'm more excited about the TL1A drugs. Those show a lot of promise. There's also a new singular biologic that targets both TNF-alpha and IL-23 (bispecific antibody) that's been able to be made into a pill. That's pretty exciting obviously as no more needles plus it could serve an unmet need of people who don't get full responses to the exciting TNF-Alphas or IL-23s and are having to combine two biologics. EDIT: Not sure why OP is getting down votes in the comments. While I maybe more skeptical of some of the treatments, especially when you start tossing cure around, we should all be working together to stay optimistic and hopeful for the future yet grounded. Down voting someone for their optimism doesn't help that in my opinion and makes us seem like a bunch of grumps...11
u/arlo78zLove the optimism!3
u/Intelligent_Web3887Track down the top researchers in this field and learn as much as you can. We all need to work together to figure stuff out and spread good information3
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116r/SpinalStenosisDisc regemeration for the rich?Exact-Task-7433160%2960.5stem cell therapy2026-03-29↗
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u/spindlebloodGonna preface this by stating I'm no where near an "elite athlete" or have infinite money to throw at my pain. I do have DECENT health insurance (by US standards) and I've been in pain since 2022, so over time, I'm sure I've thrown a decent chunk of money at this problem (I would rather not think about how much exactly bc it's depressing.) I've tried just about everything you can possibly think of. I did contact a clinic in town here about PRP/stem cells initially for my hip labral tear which I believe contributed to my eventual back injury that occurred the same year. This clinic (Bluetail) is specifically working with the FDA to try to get insurance to start covering these procedures. And even THEY told me they would not advise getting either stem cell or PRP for my back. They indicated it might work better for my hip. Fast forward about a year after my injury, I finally saw a very well respected hip preservationist surgeon at Washington University in St. Louis about it and she basically told me not to bother with any stem cell procedures. She indicated that the "type of stem cells needed to make an actual difference would be illegal to administer in the US." I'm paraphrasing here a bit bc it's been ages since I've seen her but that's the gist. Since insurance doesn't cover it, I figured it would be a very expensive gamble. Instead of this procedure, I opted for Intracept procedure bc I was able to get my insurance company to approve it. Without insurance, it costs $45,000, roughly. It's been since January 21, 2026 that I had it. I just traveled over 4 hours on a plane last week and my back did really well, so maybe the surgery is helping me. Also a coworker of mine has had both PRP and stem cells on his bad knee and neither of them helped so he basically just lit like $14k on fire. Ugh. I've heard some ppl say they work. I'm starting to wonder if it's just a placebo effect though. I had a post surgical MRI that confirmed my BVNs were fully ablated post op from Intracept so at least I know my surgeon was effective at killing those nerves that live inside my L5-S1 bones that are responsible for carrying discogenic pain signals to the brain. Anyway I just wanted to share my perspective as someone dealing with this crap since 2022. I also worked with some of the very best PTs including Aaron Horschig (Squat University) and a guy at the Central Institute for Human Performance (McGill certified clinic.) have also communicated with Stuart McGill directly over email. I thought about saving up some money to go see him in person for an eval but I'm waiting to see if Intracept helps first. My diagnosis is DDD at L5-S1, multi level lumbar facet arthropathy, disc herniation and annular tear of L5-S1, right moderate foraminal stenosis, left mild foraminal stenosis, modic type I changes, slight retrolisthesis, and a few disc bulges at other levels that are more minor. Plus L hip tear, hip dysplasia, impingement, B/L acetabular retroversion, and persistent bone marrow edema of the right SI joint which may be nr-AxSpA.8
u/CapitalElk1169I was just approved for PRP/Stem cells here in Canada Will only cost me about $1000 CAD I looked into it in USA first and was looking at $15k USD until I found out it was available in Canada as well... Happening in a few weeks, I'll post about it after it happens and we'll see what the results are like....3
u/rvega666!remindme 1 day2
u/CoffeejiveReally wish they would write a book or just talk freely, athketes that is. If you look at Tiger, he has had 7 surgeries, says a lot re $$$ thrown at injuries. Have various tears, stenosis, impingement, oa,etc, lordosis, cervical, lumbar, knee2
u/Eastern-Sector7173Tiger woods hooked on oxys. That tells me a lot.2
u/CoffeejiveAlso, intracept, radio frequency ablation, have had x2 procedures with c being more effective than l, but the si absolutely kills pain wise1
u/Kind_Swan_7124Please look into BPC-157 and TB-500 Peptides. They will change your life.1
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117r/BANDOFBROTHERSOFSRNEDr. Henry Ji’s affiliationsFate-it-is270%1360.2regenerative medicine2026-03-06↗
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u/JPPS_2MY MAN! Quite the compilation! I saved this post for future reference. Thanks so much, Fate !!!11
u/SaabilThan you very much for sharing6
u/Fate-it-isChatGPT created Microsoft Excel file, but I’m not sure it can be opened in Reddit. I’ll try to make a new post and hope it works.5
u/Fate-it-isYes — here is a clean chart of the main companies tied to Dr. Henry Ji and the scientific / intellectual-property focus of each. I’ve split it into direct affiliations and indirect / transactional ecosystem ties so it is easier to follow. Henry Ji / SRNE ecosystem chart Company / Entity Ji affiliation Direct or indirect Scientific / IP focus Key basis Sorrento Therapeutics (SRNE) Co-founder; director since 2006; CEO/President since 2012; Chairman since 2017 Direct Core platform company built around the G-MAB fully human antibody library, plus immuno-oncology, ADCs, cell therapies, oncolytic virus, and lymphatic delivery platforms Sorrento SEC filings say Ji co-founded Sorrento and that the G-MAB Library was initially invented by Henry Ji; filings also describe G-MAB, ADC, DAR-T, Seprehvec, and Sofusa as proprietary platforms.  Scilex Holding (SCLX) Chairman / Executive Chair; also previously CEO of Scilex Pharmaceuticals Direct Commercial-stage non-opioid pain platform; owns/controls brands such as ZTlido, ELYXYB, and through subsidiary Semnur, SEMDEXA / SP-102 Scilex’s official bio and SEC filings describe Ji as Chairman/Executive Chair and former CEO of Scilex Pharma; Scilex filings identify the product/IP ownership structure.  Semnur Pharmaceuticals Treasurer, Secretary, board member since inception; tied through Scilex Direct / controlled via Scilex SP-102 / SEMDEXA: non-opioid epidural viscous-gel dexamethasone product for sciatica/radicular pain; patent family disclosed as extending to 2036 in company materials Scilex SEC filings say Ji has served as Semnur’s Treasurer, Secretary, and director since inception; Scilex materials describe Semnur and SP-102/SEMDEXA IP.  Scilex Pharmaceuticals Board member since 2016; served as CEO 2016–2019 Direct Pain-product operating subsidiary; key marketed asset ZTlido and development programs including SP-103 Scilex SEC filings describe Ji’s operating role at Scilex Pharma.  Vivasor Holding / Vivasor, Inc. CEO Direct Not a classic legacy SRNE therapeutic platform in the same way as G-MAB/Scilex, but clearly part of Ji’s newer post-SRNE affiliated corporate network Recent Scilex/Semnur SEC filings state Ji currently serves as CEO of Vivasor Holding Company and Vivasor, Inc.  TNK Therapeutics Sorrento-controlled / Ji-linked through SRNE Direct through SRNE Cell therapy / CAR-T–related platform; Sorrento filings describe immuno-cellular therapy programs and TNK’s role in contributed CAR-related IP Sorrento SEC filings refer to TNK and contributed proprietary CAR constructs/IP in the Celularity transaction.  Sofusa / Sofusa Lymphatic Delivery System Sorrento-acquired platform under Ji-led SRNE Direct through SRNE Lymphatic drug delivery using proprietary microneedle / microfluidic delivery into lymphatic and systemic capillaries Sorrento 10-K and Sofusa materials describe it as an acquired proprietary lymphatic drug-delivery platform.  Virex Health Acquired by Sorrento Direct through SRNE Diagnostics using enzymatic + electrochemical amplification for very low-level analyte detection Acquisition announcement describes Virex’s proprietary electrochemical/enzymatic amplification technology.  Levena / Concortis SRNE platform companies / subsidiaries Direct through SRNE ADC technology: linker-payload / conjugation know-how used in antibody-drug conjugates Sorrento filings describe ADCs as a core proprietary platform within the Ji/SRNE ecosystem.  Virttu Biologics / Seprehvec platform SRNE-controlled platform Direct through SRNE Oncolytic virus program, including Seprehvec Sorrento filings list Seprehvec/oncolytic virus as a proprietary platform.  Celularity Transactional / strategic tie; SRNE and TNK contributed IP in exchange for equity Indirect Placental / regenerative / cell therapy company; key tie is that SRNE/TNK contributed certain CAR-related IP and received Celularity equity Sorrento SEC filings state that Sorrento and TNK contributed certain proprietary CAR constructs and related IP to Celularity for Series A Preferred Stock.  NantCell / NantWorks / ImmunityBio ecosystem Collaboration, licensing, and later litigation/counterclaims Indirect Main tie appears to be antibody library / immunotherapy rights, not ownership control by Ji; later became part of the broader Nant/Sorrento disputes Sorrento’s older SEC filings reference an exclusive license agreement with NantCell; ImmunityBio later disclosed claims tied to Sorrento’s antibody-library agreement.  OQORY, Inc. Ji signed as Chairman of the Board in transaction materials Indirect / newer affiliation Public filings tie Ji to board leadership, but the scientific/IP profile is less clearly established in the sources I checked than for SRNE/Scilex/Semnur Vincerx-related filings show Ji signing for OQORY as Chairman and for Vivasor as CEO.  The IP map in one glance If you want the scientific/IP families rather than just the company names, the network looks like this: IP / science family Main company t4
u/Comfortable-Heart529AI or anyone else can paint any sineros but sadly all roads lead to the brutal truth, the PPS3
u/Early-Blueberry838great work. where is Oorqy?3
u/Firm_Ad_8895Great job3
u/SRNEInvestorDid ChatGPT happen to find a single investor that made money from any of these ventures other than Henry? That’s a question I would love to see answered.1
u/Kmcoyne0519Thank you!1
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118r/patientgamersBeating Assassin’s Creed 2 as a Pacifistcoolwali2430%6860.1PRP knee treatment2026-04-01↗
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u/GwynFeldYou should post this in the AC sub. I think people will be more receptive there. It's a bit too niche for this one.199
u/Desperate_Acadia_298It’s a simulation of memories. So you’re not actually killing anyone. Despair meter: 0. There I saved you a lot of trouble.76
u/SplayFullMake a YouTube video houle have an audience for those types of runs32
u/coolwaliHere's Part 2 I couldn't fit in the main post: Sequence 13: Bonfire of My Patience Sequence 13 Memory 1: Florentine Fiasco The mission starts with Ezio needing to sneak into Florence, which is now under Savonarola's control. The city is crawling with guards. Fighting is everywhere. But the objective is simple: reach Machiavelli without being detected. I blend with monks. I avoid patrols. I use the chaos of street battles as cover. For once, the mission doesn't demand blood. Just patience. I reach Machiavelli. He explains the situation. Savonarola has used the Apple to control Florence's leaders. They're oppressing the citizens on his behalf. To stop him, we need to eliminate his nine lieutenants. Nine forced kills. The number settles in my stomach like lead. Memory 2: Still Life The first lieutenant is an artist, preaching that art is corruption and beauty is temptation and everything should burn. It’s the most Florence sentence imaginable, and it makes me feel sick. The mechanics don’t care how I feel. The mechanics want an assassination, and so they get one. Hidden blade. Quiet. Efficient. The confession is worse than the kill. He admits he wasn’t forced. He believed. His self-doubt did the rest. +1 Hidden Blade kill. +1 Enemy killed in a fight. Memory 3: Climbing the Ranks This mission is basically “run.” Guards everywhere, archers everywhere, and the target is above you like Ubisoft is trying to remind you that even righteousness still has a vertical difficulty curve. You can finish it without a direct kill if you’re lucky and fast enough, which is maybe the cruelest part: the sequence keeps showing me tiny doors out of violence, and then locking the next nine in my face. +0 to everything. Memory 5: Last Rites A priest on the Duomo, praying for deliverance while the city rots beneath him. It’s hard not to hear the irony in the Latin. Harder not to hear the exhaustion in Ezio’s “Requiescat in pace.” He’s older now. So am I, in a way. Not in years, but in the number of times I’ve had to tell myself, “This is necessary,” and pretend that makes it lighter. Hidden blade. Another notch. Another name. +1 Hidden Blade kill. +1 Enemy killed in a fight. Memory 6: Port Authority This is the one that weaponizes my anxiety. If anyone sees you, you desync. The game doesn’t want you to fail because you were violent. It wants you to fail because you were noticed. I successfully used the "Superblend" glitch here. I clung to the ship like a barnacle, invisible to the guards' eyes despite being three feet away from them. I felt clever. I felt like a master of the system. And then I reach the merchant, who is calmly explaining how starving people is a good way to make them obedient. The Apple didn’t invent that idea. It just made it easier to say out loud. Hidden blade. Quick. No spectacle. +1 Hidden Blade kill. +1 Enemy killed in a fight. Memory 8: Hitting the Hay A farmer is hoarding hay like it’s a moral crusade. He talks about resources, about economy, about “simple” work being vital. I almost respect the honesty of it. Oppression doesn’t always wear armor. Sometimes it wears practical boots and tells you it’s for your own good. Hidden blade again. And again the confession doesn’t absolve him. He wanted respect. He wanted to be seen. He got power instead, and used it to tighten the noose. +1 Hidden Blade kill. +1 Enemy killed in a fight. Memory 10: Doomsday The preacher is the worst one because he’s loud. He screams about famine and disease and corruption like he’s auditioning for a modern comment section. The crowd listens because fear is convincing, and because it’s easier to follow someone who promises certainty than it is to admit you don’t know what comes next. When Ezio kills him, he says the quiet part out loud: He didn’t need deception. He already believed. There’s no Apple to blame. No mind control to point at. Just a man who chose this, and a city that let him. Hidden blade. Another prayer. Another “this is not easy.” +1 Hidden Blade kill. +1 Enemy killed in a fight. Sequence 13: Memory 11: Power to the People. Savonarola drops the Apple. A generic Agile guard picks it up. "Surely," I thought, "I can just tackle him." I chased him. I tackled him. He stood up. I punched him. He shrugged it off. I threw smoke bombs. He coughed, then ran away. This nameless NPC is immune to everything in the known universe except a sharp piece of metal in the gut. +1 Hidden Blade Kill. +1 Enemy Killed in a Fight. Sequence 13: Memory 12: Mob Justice Savonarola is tied to a stake. He’s screaming. He’s praying. He’s terrified. Ezio says, out loud, that no one deserves to die in such pain. And I agree. Completely. So I end it quickly. It’s mercy and it’s murder at the same time, and I don’t know which word feels heavier anymore. +1 cutscene kill. Only three memories in this whole sequence let me keep my hands clean: Florentine Fiasco, Climbing the Ranks, and Arch Nemesis. Ev20
u/ttfnweThis is very clever and I totally see the appeal. Happy you had fun.20
u/Lord-NewbieGenuinely fun read lol - 1. Most likely since I'm a big AC Fan of the original (Desmond Arc) series. AC2 as one of my favorites games ever, and I also think of it as one the most revolutionary games of its era and most definitely if its genre. 2. You're a hilarious writer, which made this fun to read. I've seen reviews on here that equally as long so I don't get the complaints, but maybe because those game happens to be their favorites and the original AC series doesn't have much fans (most are usually only fans of IV). This was great, cheers!17
u/FrankConnor2030A masterpiece. Please finish this. I want to know if Desmond finally cracks under the weight of his guilt. Also, you could carry this on to the next couple games as well. Ezio gets pretty old, a lot more opportunities for his morals to be tested.6
u/five_of_five… yeah you should probably make videos5
u/squirrel_trotThis is actually hilarious. I love it.5
u/Gummy_JoeThis is the kind of take on gameplay that would've done gangbusters in the ol' SomethingAwful Let's Play community. Fun read, thanks for sharing!5
u/en1malTLDR but incredibly comical doing a pacifist run in a game with the word "assassin" in the title. I love it srsly - I recognised that about myself - i always try to clear games lets say diplomatic and with as few casualties as possible and love games that actually have a framework that makes it possible. Stealth games are so cool.5
u/extraextraextr"Ezio Audiobook" and "Desmond Miles Prower" had me laughing out loud for an embarrassingly long time. 😂 Thank you for this, I'm saving to read the whole way through ASAP.4
u/YouMeAndReneDupreeLucy isn't played by Emma Stone, she's played by Kristen Bell.4
u/VariousAirThis is what this sub is for.3
u/CheatcodeAUthe AC games are weirdly perfect for this kind of challenge because the assassination targets are technically "justice" but all the guards are just doing their jobs. played through AC2 normally and always felt a bit uncomfortable mass murdering city guards just to get through a crowd. this makes me want to revisit it with that lens3
u/Kaleidoscope-360Congratulations, you completed Creed 22
u/RefloniVery impressive, we will watch your career with great interest2
u/patientgamers-ModTeam[removed]1
u/-TheManWithNoHat-I won't lie I kinda skimmed through this just to get to the part when you eventually have to beat the shit out of the pope Sad it wasn't in this post, but I did read through it and holy shit it was entertaining1
u/alttestbenchAC is my comfort game, atleast until Black Flag, then Ubisoft starting naming all their medeival simulators AC, with none of the gameplay or charm of the Desmond/Ezio games.1
u/cdrex22Always enjoy a good tale of playing a game the way it was super not intended to play (shoutout NBAY2K). I like the image of Ezio playing wall ball with the poor guards of the city while screaming "I am a pacifist!"1
u/nian2326076If you want to beat Assassin's Creed 2 as a pacifist, focus on stealth and evasion. Avoid fights by blending into crowds and use smoke bombs to escape tight spots. Get good at parkour to move around without dealing with enemies. For tougher missions, find alternate paths or use distractions to get past guards. The game often lets you complete objectives without fighting, so be patient, and you'll find ways to achieve your goals peacefully.1
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119r/HFYThe Gardens of Deathworlders (Part 165)micktalian470%660.1induced pluripotent stem cells2026-03-11↗
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u/Thaum0sI really need some of that good crab goo, just put me in the goo boss.positive4
u/kristinpeanutsThanks for the chapter!positive2
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120r/mdphd25-26 Cycle Results and Choosing Between Two SchoolsDisastrousSpite7382250%1359.8regenerative medicine2026-03-16↗
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u/YaPhetsEzYou are going to Yale or you are crazy lol34
u/hellomynameis2983Yale is the better program. Also NYC is a train ride away if you're concerned about not having anything to do26
u/SatisestThis is pretty simple. Yale is the better program by a wide margin, and it will put you in a far better position for residency.15
u/MundyyyTI usually opt for self-teaching, which makes me not a big fan of the mandatory lectures at Pitt. Cet par (which seems like the right assumption w.r.t your research interests), Yale hands down Most people in med school have to self-study during preclinical anyway, because most preclinical curricula do not prepare you to pass Step 1. I found myself cutting class a lot towards the end of preclinical just so I could shove in more third-party Anki cards and UWorld, and I think a school with a stricter lecture attendance policy than mine would've screwed me in the end. You might as well go to the school where you have the most control over how, what, and when you study7
u/Suspicious-Shirt-296At risk of doxxing myself, I am a recent grad of the Pitt MSTP and now a resident at Yale. Would 1000% choose Pitt again and think it offered superior clinical training in terms of the complexity of patient cases, breadth and volume. To be honest, I have been underwhelmed by the quality of medical students here at Yale and their clinical performance on wards.6
u/Psychological-Toe359I know everyone is saying Yale, but talk to the MSTP students at both programs. Pick the program where people seem to help each other, and everyone is happy. You're gonna spend 1/8th of an average life span there so quality of life should be the most important factor.5
u/WUMSDocWithout a doubt, Yale will be a better experience and will open many more important doors for you. It's not even close. Besides the obvious pizza advantage, it's an easy train ride to NYC or to Providence or Boston.3
u/dardan3llaJust curious, why didn't you apply to WUSTL?
u/predisposedthinkingNew Haven little Italy is enough reason to choose them-1
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121r/RegenerativeAgWe have to change the way we look at our worldMobileElephant122230%1459.7regenerative medicine2026-03-15↗
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u/polymathicfunCan't help but think... The ultra wealthy looks at us, other humans, as livestocks / commodity... To generate more wealth for them... It doesn't matter to them that we are surviving mainly on calories instead of balanced nutrients... As long as the difference does not rob them of their excessive returns... But relating back to your content, I strongly agree on the minerals mainly being on the soil. Due to my personal circumstances, I am now maintaining only a tiny balcony garden, with less than a dozen pots. Even growing in pots, utillizing only some regenerative principles, these pots are still supporting many different organisms, including earthworms, rolly pollies, slugs, ants, snails.... I do enjoy their presence.. and my plants are still growing quite well5
u/TappindatfannyVery well done, you’re manifesto needs to become the basis of agriculture2
u/Rorschach_1Thanks it took years to come to practicing this. JADAM books were the most influential for me. We are on a half acre within city limits and it's amazing what you can do with that. My soil is so alive now.2
u/Kind-Elder1938extremely well put and very true. There are actually a rapidly growing number of folk who are on the same page, and who are re-thinking farming2
u/FastAd8669I've interviewed ranchers in Texas, sheep farmers in California, and sanctuary operators in Maryland. I publish weekly on Substack if anyone wants to follow along! https://substack.com/@fromthebackforty1
u/BocaHydroPost a pic of your garden, otherwise TLDR1
u/AnonynjaAll these AI essays are written in the same voice, it's uncanny1
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122r/tresslessPelage have presented only phase 2a. The rest of phase 2 for PP405 will be prese...Acceptable_Phase6241290%959.3regenerative medicine2026-03-29↗
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u/rdawg1234Did they actually complete a phase 2B? That’s just the financing announcement. It’s possible they were happy enough with 2A to just jump to 37
u/jgmcmillanThis press release is from October 2025. The meeting they were talking about in this article is AAD, the one that just happened on Saturday. I think you somehow mistakenly thought this press release is new?6
u/CyberBerserku/haircafe looks like you spoke early3
u/smurfsaysMost likely they shared all the data they're going to share. The open-label extension was the post-dosing period up to day 84. That is the data that was shared at AAD. The 3-month treatment wording appears to be an error if you look at the secondary outcome measures. It clearly shows that the OLE is "To assess the concentration of PP405 in plasma" at 84 days, and the presented data corresponds with the total enrollment. I don't think anyone received 3 months of treatment.2
u/refreshingfaceI’m tired boss1
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123r/stemcellsiPSC-derived germ cells show rare motile sperm in clinical NOA casesMD_Ex160%1959.1regenerative medicine2026-03-06↗
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u/InnominaAnatomicaCool, did you publish it?5
u/PrincipleSea3103I’m not involved or educated in the medical field so may explain/ask this somewhat crudely but do have this issue. Any hypothesis on how having variants of uncertain significance at the genetic level may play out with this method? Have VUS (unknown if cis or trans) at the TEX14 gene which is pivotal in instructing germ cells to form bonds during the spermatogenesis. With my variants they essentially have predicted them to cause sperm maturation to break down early due to missense instructions to use the wrong amino acids in forming cellular bonds. Would you expect that even if using stem cells, this breakdown would still happen in your test scenario because it’s at the genetic level?1
u/GlobalBox8288Great work! Hope it becomes available for everyone. How about NOA patients with SCO? Is this technology possible to create sperm from tissue samples?1
u/Sea-Direction691Great News. Could you care explain in simple language how will this actually help people with NOA to finally be able to reproduce. Like what would be the process?1
u/ResearcherExpress701This is incredible if true. Is there a publication ? And source that can confirm it? It seems that there are no publications or reports (from private companies) describing in vitro gametogenesis in humans. Without any such evidence or support, it seems it's just your words.1
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124r/DeadlockTheGameWhat do McGinnis players think about her changes?MeTaOMiTo140%2158.9regenerative medicine2026-03-07↗
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u/techpriestess_01Making me rethinking how i play McGinnis. The big things i used getting changed (medical specter scaling completely reworked). With lvl3 extra charges +t3 wall you can get 9 turrets down pretty quickly. Even if the turrets lost their slowing. Its intresting changes overall8
u/MelodicFacadeAs a support player, I'm not a big fan lol. I wouldn't say it's a complete nerf, but it feels like turrets are more reliablein dealing damage, but get blown up super fast now. So in order to get her full effectiveness, you have to be fairly tactical with placement Healing scaling with spirit is nice, but it doesn't give attack speed anymore. Since the range doesn't scale with healing, it feels like it's more about placing it on a turret or placing it on top of yourself and standing your ground, to get that spirit resist. I also think the wall changes are super nice, but 8 seconds isn't that long I don't think it's overall that bad for her to be played so differently, but I personally enjoyed the support build of going heroic aura, throwing your medical spectre in the middle of the fight, and then having this massive radius to help stand your ground as a team. I would also usually get escalating exposure and healing tempo, and the turrets would rack up damage, while I healed 70k by the end of the game I think I need someone else to play her and find a strat that makes her good with these tools, because on paper it doesn't sound too bad. The only thing I really hate is that they reduced the health of the turrets 40%, and all they get is spirit resist from medicinal spectre? I feel like a wraith, ivy, or infernus is just as much as a problem. Sure, a geist bomb or ivy kudzu bomb would melt them, but idk if wasting medicinal spectre is worth wasting on a charged spell7
u/UmikalooI really liked gun build McGinnis, so I'm sad they nerfed her primary fire. Turret spam is a fun gimmick, but it isn't as interactive, so I expect it will get boring quick. I really enjoy using barrage, I'll have to test how the changes feel. In my experience enemies rarely abuse the minimum range, but I don't play at high levels.5
u/TsumeiI have played Mcginnis as a turret focused support, an ult focused hero with unstoppable and runspeed, a gun tank, a gun healer and a gun split pusher. All of these playstyles were in different patches because valve are like cycling between making turrets viable and not viable every six months, and then the ult was too good so they nerfed the interactions that had into the ground and instead gave them to haze. (It was pretty good though, you could ignore movement limiting effects, so you ignored the ults own effect and ran at 15-20 m/s while ulting) I don't really love that she comes back to turrets being important as her main mechanic, mostly because noone in deadlock ever plays positions, they all just jump between walls and use their 7 stamina to avoid you. That was also always the issue with her using healing items; they are amazing if your team play around objectives, but when they all literally fly off into the sunset it doesnt matter that you have a big heal and a killbox. Overall this feels like some really strong nerfs to a character who was already at one of her weakest points. That said though, the turrets might be absolutely busted beyond belief, but we know that just means they nerf her into obscurity next patch cycle and get confused what their goal was with her again. Spectral wall losing its stamina penalty to people hit is also like a pretty gigamassive nerf that I don't think non-players of the ginnis would appreciate. It is literally your one way to try to force an engagement. The wall itself is sorta irrelevant in comparison to the damage boost and stamina penalty.4
u/OmnipotencaOverall, I view the new changes as a net loss due to three major nerfs: Spectral Wall is no longer reliable for stopping enemy advances now that it is a breakable object. Spectral Wall can no longer stun, meaning it cannot stop enemy urn carriers and interrupt their actions in general. Heavy Barrage + Mystic Slow is no longer an easy kill in early lanes since its base duration is cut in half. T2 is required for it, and that means giving up on the other T1 abilities. Though there are some good changes to her: Medicinal Specter T1 granting +40% Spirit Resist is quite handy, as smart opponents used their AOE abilities to counter the healing field in the past. Medicinal Specter's healing was only meaningful in early lanes and after getting T3 Max Health bonus. Now that regen amount scales with Spirit Power, the output curve should be smoother. Mini Turret gaining 50% longer base duration is a nice change, since its previous 24s was simply too short, demanding T3 rush and at least Duration Extender if you were going for a Turret build. Spectral Wall T3 spawning additional Mini Turrets is an interesting change. Previously, the second ability to master for a Turret build had usually been Medicinal Specter due to T1 rate-of-fire bonus and Healing Tempo buff. They changed it so that you now have a different option to consider. Spectral Wall, applying slow to enemies it passes through, is a welcome buff. It is now easier to trap the enemies who attempt to flee. I understand why the wall had to change, since it never felt good for the receiving end to get walled off and stunned at the same time. Nevertheless, it feels like I lost a strong tool that used to dictate the teamfight (especially with Echo Shard imbued on wall). It is still good for kill-catching, but as I climb through the ranks, it will be less effective as the enemy team will dismantle her wall to save their teammates. Her other abilities... are okay, but will always suffer from being a stationary deployable, and never be as impactful as pre-nerf Spectral Wall.2
u/ManicPixieFuckUpI'm kind of bummed. My favorite thing to do in the game was drop a bunch of turrets and medicinal specter on a walker or shrine and melt it before anyone had a chance to react. I don't totally know if I'm gonna play her much now. In theory you could do it with healing temp but then, you know, you gotta buy healing tempo instead of mobility options. But then again, they made her model look really bad and I got over that, so, I dunno.2
u/Zerginfestorfeels like a damage reduction overall, most people in higher ELOs just burst the turrets before they can do anything, even in late game. Feels like they want you to play like a TF2 engineer gunslinger, throwing out turrets without a care to apply more DPS, instead of an actual nest to apply as support for your allies to fall back to. Biggest drawback is they still don't allow you to drop turrets as fast as you can click the button, so there's always a delay in setting up a higher damage potential to finally challenge folks that attempt to dive you. Also not a fan of the heal change, but it's fine, it's just me needing to adapt. Turrets were beforehand already easy to burst so reducing their HP by 40% is just ridiculous, forces a more spread-out nature and even then, if the enemy is there, they pop the turrets insanely quickly.2
u/El_Gran_OsitoAs a turret spammer I love it, wall refresh wall is fun.1
u/NoContribution4441imho she's way more fun to play now and way more annoying to play against. had a game with 75k souls, 95k damage (turrets+ult, ascendant 1) edit: echo shard on wall goes crazy1
u/Present_Dimension619Horrified at the medicinal specter nerfs. Turret life - very sad. Glad to be able to get more turrets down, but kinda dumb if they just get insta-killed anyway.1
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125r/SpondylolisthesisI dont need surgery!!daninjaaa190%1458.8regenerative medicine2026-03-04↗
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u/Ok_Trip9238I hate to be the bearer of bad news but I dont think this is a complete fix. Im almost 23M and had spondy since 19 from running too much too fast without recovering or training properly. I did all the conservative pt and heard steroid injections are only for a few months of relief but if you continue pt even during that, it might help mitigate the effects when the steroid wears off. When the nerve is so compressed from a collapsed disc, there isnt much conservative movement to do without causing pain and you put more pressure on upper discs anyways while suffering with nerve damage. I had surgery almost 5 months ago and i am the happiest and painfree ive been in years. Not saying its a death sentence and you should try to avoid surgery but i rather have 15-20 years of happiness before going through that pain all over again4
u/BuckityBuckYou can’t do steroid injections very often without causing damage, but if your doctor expects it to be a one time thing, that’s great.3
u/Agile-Development-88That is amazing news! So happy for you. You’re giving me hope. As a fellow almond mom of a daughter with grade two spondy may I ask the name of your doctor?! I’m desperate to keep my daughter from needing surgery.2
u/Similar_Blackberry29that’s amazing for you but i’m curious how you know it’s a one time injection? don’t these last like 6 weeks to a few months?2
u/NJcovidvaccinetipsSuper happy for you op. Similar situation and shot didn’t do shit for me. PT is definitely helping to build strength and reduce pain. We’ve gone from living in absolute hell to feeling bad which is a step in the right direction2
u/omsy828Which scans showed your bursitis? Glad to hear you’re doing better and I hope it lasts.1
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126r/AcneScarsTreatment for scars co2 with subcision or co2 with prp and revitalisationTasty_Jury8842150%1858.7PRP knee treatment2026-03-26↗
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u/bee_zahIt might be the lighting but I think your skin looks really good? Maybe a few microneedling sessions but it’s pretty smooth.9
u/SangitaCPatelMDCo2 fractional (or Erbium fractional) and PRP is a good combo2
u/RoutinePrune7887Les lasers ont aidé ou pas ?1
u/MedicalProgress7220Hi, your results look great! I have similar scaring would you mind sharing the doctor you went to I’m having trouble finding someone who does subcision!1
u/Unlucky-Eye-3886Which fractional co2 laser was it?1
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127r/microbiomenewsFasting primes small intestinal regeneration after damage via a microbiome–metab...basmwklz1090%57.9induced pluripotent stem cells2026-03-30↗
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128r/tresslessPelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Pr...New_Stable8642270%657.6regenerative medicine2026-03-26↗
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u/RedAsh521Nothing is mentioned about presenting specific data from the trials… thinking they will just say “here’s how our product works, it had significant effects” and nothing new or outstanding.15
u/Hotrock21Someone posted this days ago. What people are doubting is that Pelage won’t have the peachy data everyone hopes they do.12
u/Dry_Bunch_1105Live stream that shit!3
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129r/transhumanismIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz50%4857.1regenerative medicine2026-03-10↗
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u/Salty_Country6835The scenario assumes aging is the main thing regulating population, but that's only one source of death. Even if aging were cured, people would still die from disease, accidents, violence, and environmental risks. Life extension doesn't equal true immortality. If aging disappeared tomorrow but accidents and disease still existed, how different would life expectancy actually be? It also assumes governments could realistically ban reproduction. Humans don't reproduce through a centralized system you can switch off. Even very powerful states struggle to control fertility today. The other missing piece is demographic transition. Wealthy, technologically advanced societies already trend toward lower birth rates on their own. Historically when technology changes reproduction or lifespan, do societies ban behavior or adapt around it? More likely we redefine what "human" means before we ever reach stable immortality. Life extension, biotech, artificial gestation, and maybe even off-world settlement would reshape the system long before reproduction bans become the main lever. Would the real shift be population pressure, or the definition of human life itself? If life extension arrives gradually instead of instantly, what demographic pattern do you actually expect to emerge?16
u/Azure_ProvidenceAccidents and disease still exist. Some people will still refuse the treatments. People will still die so the real question is how much of a difference between the new birth and death rate be? People were afraid of overpopulation for decades but it turns out once people have a decent standard of living the birth rate naturally drops. It is entirely possible immortal couples will choose to not have children at all or stop at some small number that happens to meet the replacement rate. People in poor countries reproduce in high numbers due to lack of birth control access. Poor families in subsistence farming conditions also need more kids as a workforce. If these issues were solved families would shrink.5
u/TonightSpiritual3191Everyone saying it’s not going to happen by 2050 might be delusional. Truth is we’ve entered a new reality and no one knows where this is going to lead and how fast or slow adoption will be. If I had to give a prediction I’d say we might see people moving to more remote areas and maybe even the moon or in orbit. I think overpopulation isn’t a problem but people might choose to delay having children if their biological clocks are extended5
u/antii79By 2050? Reminds me of "women having sex with robots only by 2025". We're nowhere near close to that5
u/mikasaxoNo. People are still going to continue dying for hundreds of years even if aging is somehow solved. Diseases, accidents, war, and just the fact we don’t have equality of treatment2
u/medved76Humans are already naturally solving the problem of population growth.2
u/marilynjaynaIf we cure aging then people will be fertile for longer and will delay having children. That will severely decrease the # of kids over time naturally and without govt intervention.2
u/Users5252People would simply reproduce less2
u/HitandMiss28It’s almost like you’d be happy and relieved to realize there’s a god at this point.1
u/Useful_Calendar_6274no unless values change radically. people will still die from other causes, mainly infections1
u/golddragon88With decreases in the infertility rate exceeding all predictions. Stopping aging might be a necessary action just to keep the species alive. So no I doubt they'll doubt ban reproduction.1
u/JollyApplication6627Depends on the death rate. Immortal doesn’t mean invincible, as in, if you were immune to aging, jumping face first into a woodchipper would still kill you.1
u/SargeMaximusGovernments have held humanity back for so long1
u/Trash_Princess__This would be why space travel is so important. We would be able to spread throughout the universe rather than destroying earth.1
u/Pasta-hoboImpossible. All you need to reproduce are two default humans of opposite sex. The realistic approach would be to maximize research for 100% effective birth control. If you can't stop people from making more people, you can at least make sure the majority of people born are born on purpose.1
u/CryptoFourGamesDrugs and violence would likely remain as population control. Besides that, space colonization. Population only remains a problem in a world where we're not colonizing space1
u/NVincarnateNo. People would select for not having children naturally as intelligence and life expectancy increase as a result of global technological advancement and living conditions decline. Nobody wants to bring children into this trash fire of a world as it is. Why would population increase out of control?1
u/In_the_year_3535We can't simultaneously complain about low birth rates and an aging workforce and a fountain of youth. As for our minds handling it memory is kind of like the harmonic series were age 4 is 1 year, age 5 counts for 1/2 since you have 2 years (4 and 5), 6 counts as 1/3 (4,5, and 6) and so on. The harmonic series doesn't converge, we'll never run out (1000 will be roughly 1/1000th) but will always be heavily influenced by our earlier years.1
u/Different_Guess_2061We'll have artificial wombs and colonize Mars, so it won't matter: https://youtube.com/shorts/khurldIShF8?feature=share1
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u/dust_of_the_starsLet's put aside the very unlikely scenario that immortality will be available by 2050 and focus on more realistic problems. There are currently more than 8 billion people living on Earth, and the growth of population is exponential, even with falling birth rates. The space and resources on Earth are limited, and the nature destruction is catastrophic. Worry on how to deal with the real problems in 2050 rather than fearmongering about someone taking your rights for reproduction. Reproduction will not be banned but encouraged by the government because they need wage slaves and cannon fodder for wars, so don't worry about this part.
u/SeishominMinor semantic point but I'd argue that aging isn't a failure and removing it isn't a 'cure'. I appreciate this might simply be a philosophical position though.
u/-7-luckI just dont think they will soon, by 2050 much less. The idea that there's just "scientists" working around the clock on this. You understand you pretty much have to get a phd to meaningfully work in this field? That itself takes years and years. Who is sacrificing their own life to make others' lives longer?-2
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130r/sesamoidHope for thySuccessful_Lime_1349150%1056.8regenerative medicine2026-03-06↗
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u/Distinct_Audience_41Thanks for your story and healing journey!3
u/Successful_Lime_1349Also I do credit a large part of my healing to doing the BMAC injections. It was pricey but worth it.2
u/No_Ingenuity4846Yo just wanted to say I was in the same boat. I even made a post about it a few months ago. I had a hairline fracture that I spent months healing and even as I ramped up running volume the pain was only at a 1-2 out of 10 but I was convinced when I got my MRI it was going to show something was still going on. Came back completely clean. (Of course now I'm having sesamoiditis in my other foot but that's a different story.)2
u/neuranxietyCurious about how you feel your climbing shoes contributed to the injury - how much were you downsizing? Or do you think it was more of a fit issue? I first noticed my sesamoid pain after a rock climbing trip and I've become increasingly convinced that the shoes I wore on that trip were a huge part of the issue. Slightly too narrow in the toe box, but mostly they were just really soft and not supportive enough for my use case (high volume of tall single-pitch lead routes over several days). Have you started climbing again since you got the good news?2
u/Automatic_Victory682THIS!1
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131r/soccercirclejerk🟥BREAKING🟥: Real Madrid insider leaks internal ChatGPT historyFaresAlN3110%1756.7PRP knee treatment2026-03-25↗
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u/JustaBSJfanWhich big black footballers they talking about?32
u/GrapefruitGloomy8493Director of medicine at RM: Dr nick riviera16
u/Emp31High effort jerk right here13
u/ElFanta837
u/EmbarrassedEffort725Pep Guardiola baldness?! 😏🤷 Weird! 😆2
u/pitch_black01I don't know what's worse, the fact people make these things for views and likes or the fact people think its real 😂2
u/Flashy_Pollution_996Hola, ChatGPT, Vinicius está llorando otra vez. ¿Qué suplemento debería tomar?1
u/MjolnirnerdAny way this is real?1
u/ParticularCattle5647Victor Kompany tactics summary = Use your head1
u/ImadDdopestAlso what do i feed Vinicius ? (no racism please)
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132r/CerebralPalsyStem cell therapySillyPinguin50%4256.7stem cell therapy2026-03-28↗
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u/EffectiveFickle7451As someone with CP I honestly hate when parents are trying to “fix” their child. Kids with CP and adults can live for filling lives. Quality of life for disabled children does not mean walking or talking. It means having a safe and loving environment for them to grow and be proud of their disability in a way that they don’t believe they are a burden because of their disability. Disability is something that doesn’t need to be cured. Another quality of life is their mental health how can do things if they are depressed or have anxiety. So no i don’t think stem cell is worth it. And make sure to teach your child that their disability is nothing to be ashamed of. Honestly CP has given me a lot of opportunities. I do some public speaking for different stuff and honestly i don’t think i would be doing that or as confident if i didn’t have CP. Whether they walk or talk is something that the future holds. You should focus and building a loving relationship because people with disabilities in general are more prone to get PTSD. Thanks for coming to my ted talk!11
u/abayjWe are actually going to be going to Duke in the US for our second round next month. We got so many benefits from the first round. We got mood regulation [he was a very fussy baby], better eye tracking, some babbling, and arm movement. We also do a ton a therapy, so that helped too but I feel like the stem cells gave him a boost he wouldn't have otherwise gotten. Highly reccmonend an intensive therapy program after for PT and OT. Was super helpful as well. Also though, as I tell all parents, go in with the mind set it is a therapy. It isn't going to effect every child the same and you may see more or less gains then another parent. But as long as you go to a reputable clinic and it is safe, I think it is a wonderful resource!6
u/JAW402We are currently down in Panama getting his first treatment. He will be 2 on Saturday. We got denied for the Duke trials, and yes it's expensive. He has CP from congenital CMV, along with a couple other issues.2
u/EbronsteinI live in New Jersey and I'm trying to get any info I can on stem cells. Does anyone know anything?1
u/WatercressVivid6919Have you tried posting this in the Discord server? https://discord.gg/tEuptRdKDz1
u/bob-the-liciousAnd since we are all here - any recommendations around PHX for stem cell practitioners? We have our stem cells banked for the kiddo but our doc retired. We have a ton of therapy in PHX in July and would avoid flying around (coming from Belgium and all).1
u/Dark_Rottie18I tried to apply quite a few years ago but at the time they were only taking children, not adults. Which makes sense, but still.....😡😡1
u/curious-dev199Can someone please share some light on the cost it takes for someone who is not in the US for this treatment? Also what's the max age this treatment is done? Thanks in advance!1
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133r/mdphdStrong MSTP BME/BioE Programs?Temporary_Shirt_1986140%1056.5regenerative medicine2026-03-08↗
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u/Novel_Hurry_4282in addition to the three you mentioned... blue chip programs: harvard-hst/MIT, Stanford, Duke, hopkins, UCSF-Berkeley, UW "under the radar": Michigan, CWRU, UCSD, Baylor-Rice, Pitt-CMU15
u/FicrabTexas A&M is not typically thought of as having a top-tier MD/PhD program, however BME is probably the sole area where they might outshine other programs. The director herself has a strong BME background, though it looks like she's pivoted to more infectious disease focused work. Be advised though that any programs in Texas go through their own medical school application system, separate from the rest of the U.S.7
u/Zakky121Hopkins has a pretty strong program too, I’m honestly looking for the same so would love to exchange tips/info with another 👍🏿5
u/Turbulent-Alfalfa-40If you are a ok with a MS instead of a PhD, check out ASU. Also Indiana have a partnership with Purdue I think3
u/A_Genetic_TreeHow has no one said Carle Illinois College of Medicine yet. They are engineering focused in general and md PhD program2
u/BagAway572More under the radar programs: UIC, UMaryland (with UMD in College Park), Alabama, Indiana (with Purdue), OSU, Wisconsin2
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134r/SecretsOfMormonWivesWhat do the girls want from Demi?Positive-Canary93471170%5756.4stem cell therapy2026-03-13↗
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u/jake3h7mI’m so glad you said this! I was so confused at their reaction to her not hanging out with them before DWTS as well. Whether it’s to her face or behind their back, they make it very clear that they do not consider her their friend or that she ever will be again. But then they got upset that she was staying at a separate hotel and was just meeting up with them for DWTS? What other obligation does she have other than that event? Why do they make it seem like it’s so terrible that she doesn’t want to hang out with them beforehand or stay at the same place when they make it clear that they collectively hate her?103
u/Fear_PearI personally want a full cover of "True Colors" because that was the funniest thing I've ever seen57
u/Own-Ad-7201They want her to be the polarizing villain because without her the attention goes back to showcasing their own problematic behavior. It was comical when Taylor was like her absence puts so much pressure on us and we have to scramble. There’s like 7 of them, how is her absence making that much of a difference for yall.50
u/jake3h7mThat part! plus Whitney is the only one whose consistently been spot on when it comes to shit like this even when her opinion may not be popular she’s usually been proven right and I just think it’s very telling that despite how much she loves momtok now and is in the show she still supports Demi and I dont think she would still bring it up or be by her side unless she felt she had a reason, especially with how important her career is to her. idk.47
u/bephanaThey wanted to bully her again, at this point they just always need a person present that they can shit talk to.44
u/SupportPretty7228But they don't care what Taylor does? Taylor can flirt with Chase and it's no big deal? How the girls choose who to hate on for what makes no sense. They have the maturity of middle schoolers24
u/SarppaliTHIS!!!! Like it makes no sense. It is all just for clout to make it more interesting. Like I would NEVER go back to people like that, the way they treated her even if its somewhat justified.23
u/karenscafeI was thinking the same thing. I couldn’t understand why they were so pissed she wasn’t around when they made it clear they didn’t want her there? It’s weird. They should’ve been happy she wasn’t showing up and quit filming. But they’re not because they realize this is a TV and they need a villain. Which makes all their talk about who’s “genuine” sound ridiculous.23
u/GaladrielllllOkay sorry this message is long: Okay, I obviously don’t know any of these people personally — I only know what’s shown on the show, social media, and what’s discussed online. I do have a Master’s in Psychology (I’m not a practicing therapist, and I finished the degree within the last couple years), so take this purely as an observation from someone who studies behavior — not as a professional diagnosis or anything like that. Honestly, the biggest factor that people often forget with reality TV is production. Producers shape storylines every season because conflict keeps viewers engaged. Editing, selective clips, and encouraging certain conversations can amplify issues that might otherwise be small or resolved quickly in real life. So when something feels confusing or inconsistent to viewers, a lot of the time it’s because we’re seeing a highly curated narrative, not the full context of what actually happened. From a behavioral standpoint though, I can see why tensions around Demi keep resurfacing. On the show, she sometimes communicates in ways that come across as blunt, confrontational, or dismissive toward the other women. Whether that’s editing or her actual communication style, that kind of delivery can trigger strong reactions in group dynamics — especially in tight social groups where loyalty and perceived respect matter a lot. Group psychology also plays a role here. Once a group forms a shared perception about someone (fair or unfair), it tends to reinforce itself. People start interpreting that person’s actions through the lens of “this is who she is”, even when the behavior might be neutral or unrelated. That can create a situation where the person is “damned if they do, damned if they don’t.” If Demi shows up, people may interpret it as performative; if she doesn’t show up, it’s taken as proof she doesn’t care. Another thing that often happens in reality TV groups is what psychologists call social contagion or group polarization. When several people share frustrations with one person, those feelings can intensify over time as the group validates each other’s perspective. What might start as a disagreement between two people can quickly become a larger group conflict. That’s why the reactions you’re describing can look contradictory: • They say they don’t trust her or want distance, • but then they’re upset when she actually creates distance. Psychologically, that tension often comes from unresolved conflict. People may say they’re done with someone, but emotionally they’re still reacting to the situation. And then you add the pressure of filming, public scrutiny, social media commentary, brand obligations, and producers pushing for conversations — and it becomes a perfect storm where conflicts keep getting revisited. So from my perspective as someone who studies psychology (again, not diagnosing anyone): it’s probably a combination of reality TV production, group dynamics, communication style differences, and unresolved conflict. When all of those things collide on camera, it can make everyone’s reactions seem confusing or hypocritical from the outside. That’s just my take watching as a viewer though — the reality is we’re all seeing a very edited version of a much bigger story.21
u/Sea_Papaya_419They all, including Demi did the same thing to Whitney. They don’t think you should come and go into mom tok/ decide when you’re going to be friends with the girls whenever you want something. I also think a lot of it is edited especially the confessionals because they all follow Demi except Jen on socials so🤷‍♀️19
u/Greedy_Bit8650Their tryna bring her back for a storyline  tbh the whole Marciano thing would work if they didn’t broadcast and try to create a storyline with the sa accusations, they wouldn’t have much of an controversy bringing her back14
u/LittleBabyOprahI was hoping to tune in this season and finally see the problematic ass storyline left behind but no, Hulu just haddddd to revamp this beef that no one cares about except Jessi because it distracts from her own actions and her weird sad marriage, and Jen because she has the maturity of a zygote. Calling Demi on speakerphone gave me middle school flashbacks, that was so cringe.11
u/haleykatThey want her to be the villain so they can be catty and not get any hate.10
u/Inevitable-Past-4069These women equate showing up for any and all events to how much worth they think someone has as a friend, but only selectively. They barely shit on Jen for not making maycis book launch because she was sick (not because she was, you know, busy rehearsing for DWTS 6-8 hours a day everyday) but they DRAGGED Whitney for not coming when she was doing the same thing as Jen??? Also Taylor has missed plenty of events but I never hear them shitting on her, she's always excused for her absences and her atrocious behavior...8
u/shay_shawI’m watching the episode with the reunion and it’s even more clear that Jen fucking lied about what she saw. And Jesse is out of her mind for being so judgmental when she was the one who actually cheated on her terrible husband. I don’t think she went hard enough on Jen, I would’ve lost my mind. That kind of betrayal on national television, I would’ve hit below to belt too.7
u/libreotusi am sure a lot of it has to do with them feeling like it isn't fair that she is being paid under contract when she isn't "working". i'm sure they're all tired of the cameras 24/7. i know the moms on dance moms would get pissed at melissa for not "doing her job" and participating in the drama the producers were orchestrating. the show makes them all look bad and they probably think that if they have to keep showing their asses on TV then demi does too if she wants the benefits. though really they should consider how hated demi is even without the screentime lollll they really don't need to go so hard on her at this point. i'm not a demi fan but good lord some of the scenes were intense6
u/whydoyou_caresomuchI think a lot of the issue is all the shit Demi was posting online during this time. The comment sections too. That’s what is hard about the show coming out later on. I was legit so confused when it started out with them all being cool. In my mind filming started after the Reunion, but as we know, it didn’t. Hahah6
u/Rosemary-Sea-SaltProbably to disappear but the producers said 🙅‍♀️3
u/bigtimechipDemi is the biggest cry bully ever and was piggy backing off of Macy and Mikayla's abuse situations to garner sympathy for herself. Low key disgutsing behaviour2
u/Hollinsgirl07I think it’s the hypocrisy of it all. She chose not to go to Whitney’s event for mental health but couldn’t accept that from anyone else as a valid excuse. She got upset after the reunion and “quit” but still wants to go to on camera events with the girls. I think they feel like if she wants to leave she should fully leave or fully stay. Which I get. Like pick one and really show up or don’t ever be on the show again. If she wants to stay for the clout fine but like own up to that and move on.2
u/CaterpillarNearby422They all need therapy lol1
u/KLC_BIt really feels like Demi is in an abusive scenario. If she’s saying different things in private I feel she just doesn’t want anything on camera than the story she may have fabricated to her geriatric husband1
u/lquintelI thought they were mad she went to DWTS? Why would she go and sit with them and play nice for the cameras when they aren't speaking? Doesn't make sense. Thats how I took it anyways, that they didn't want her there at all1
u/snipsnap987what demi said in the reunion crossed so many lines, and to girls that are less confrontational or good at confrontation (miranda, mayci, and jen). i really don’t think demi should come back to the show after that, and i think the girls are annoyed demi is pretending to be part of the group but doesn’t show up. and in a way that’s hypocritical since demi has bullied the other girls (whitney, taylor, and jen) when they didn’t show up to film for mental health reasons
u/Few_Essay_5197they want accountability and for to just own up to her BS. also this a scripted reality show as well as they are influencers who get views for drama. I don't think they don't want to be her friend, they just want her to be a better her.-2
u/OppositeSpare2088Demi is still a snake I wouldn’t trust her or Whitney actually I wouldn’t trust anyone on this show lmao. I think Demi doesn’t want to be seen as the villain anymore and wants to get on everyone’s good side again. Imo she’s also doing it to try to get more people to side with her with the Marciano situation.-3
u/CreepyRelation968They don't want anything from Demi, that's the point. No one wants to be around Demi so they are rationalizing their thoughts by discussing it.-4
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135r/InterstellarKineticsA Study Of 10,000 Knee Arthritis Patients Across 139 Trials Found That A Knee Br...InterstellarKinetics450%256.3PRP knee treatment2026-03-30↗
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u/InterstellarKineticsThe ultrasound ranking is the buried finding that should alarm a lot of physical therapy patients. Ultrasound treatment for knee arthritis is common, frequently billed, and according to this analysis of 10,000 patients is the single least effective option of the twelve therapies tested. Meanwhile the two treatments that topped the list, knee braces and warm water exercise, are among the cheapest and most accessible interventions that exist. This paper is essentially saying the healthcare system has the cost-effectiveness relationship exactly backwards for knee osteoarthritis: the expensive high-tech options underperform and the cheap simple options lead. That gap between evidence and practice is what clinical guidelines are supposed to close.1
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136r/CervicalinstabilityCervical_Instability Post by Moderator against RegenexxProof_Draft4420110%1356.2regenerative medicine2026-03-03↗
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u/EmhillyI’ve worked in clinical research for years and I find it incredibly hard to believe Centeno wouldn’t at least be doing retrospective chart reviews and publishing results if results were statistically significant. Publishing peer reviewed studies would even be great for his marketing and for obtaining FDA approval or EUA. I find it very strange…13
u/kpt85Anecdotal experience does not mean something is common. That’s great your daughter has improved, I hope there are many more experiences like this. From what I’ve seen, most of the criticism sent towards Regenexx has to do with the way they advertise their services, the process they use, and the lack of willingness to adhere to basic research standards to actually move the science forward as opposed to gatekeeping all of it and releasing whatever information serves his purpose. From my limited interactions with Centeno I find him wildly unprofessional, but I hope he or anyone else can help more suffering patients in a way that is more widely successful, more transparent, and doesn’t require liquidating your retirement.9
u/JewaldHey proof_draft, thanks for the shout, hope you are well. I strive to be fair and open-minded, though I'll admit I'm not always perfect, that's for sure! The first link, iPSCell.com, is a blog by Dr. Paul Knoepfler, professor at UC Davis and a stem cell scientist. https://health.ucdavis.edu/cellbio/faculty/knoepfler/ Don't know him personally, but seems like a great guy, and his website is a good resource for patients considering stem cells or other regen med stuff. Stellar resource for patients. Hopefully we have a good treatment, potentially cure one day, and both this sub and mine ( r/cervical_instability ) become useless. That will be a good day. Until then, hope everybody is hanging in there. It's not an easy condition.... I live it everyday myself have for many years. I'll catch you another time✌️6
u/dudeunkiwn_ffhOh they both him and centeno got beef. I get both sides though5
u/dudeunkiwn_ffhYup Kaiser tends to do that. Who was the doctor was it Dr.Hung or Kim. They are asses tbh3
u/Agreeable_Muscle_279They have some history lol2
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137r/DebateEvolutionHow tweaking genes that control embryonic development can lead to the evolution ...Benjamin5431320%356.1induced pluripotent stem cells2026-03-04↗
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u/junegoesaround5689Great mini-lecture on evo-devo.positive3
u/Academic_Sea3929It's amazing that creationists never bother to look at how development works. It's clear that they are assuming (always implicitly, never explicitly) that many new genes are required for new body parts/plans, but they very clearly aren't.negative2
u/Coolbeans_99Very cool, i’ll have to read it over a few timespositive1
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138r/ketoscienceAspartame exacerbates cerebral ischemia–reperfusion injury via mitochondrial dys...basmwklz200%555.8induced pluripotent stem cells2026-03-08↗
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u/DoctorHathawayThat it! I will not be giving my pet mice any more Diet Coke, no matter how much they protest!!positive8
u/ridicalisAlmost made me spit out my Zero Sugar Dr Pepper. I already took erythritol out of the diet recently due to the possible cardiovascular implications. You dropped that bit about sorbitol not too long ago. I can live without sweets, but it's becoming increasingly difficult to find a sweetener that isn't problematic.negative1
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139r/IndianSkincareAddictsI had posted about my journey on isotretnoin. This is an update, 3 years later.Zenodorys730%8055.4PRP knee treatment2026-03-10↗
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u/I0l0l0l0l0lOmg Dude you're so handsome 🫣🧿33
u/whatevaa007You’re a fine piece. My my11
u/Cloudsinmytea1Whatever you say Honey10
u/ghuchusI am on isotretinoin currently. The mental peace that comes from not having painful acne all over my face outweighs any of the negative mental health effects of the medicine itself. Sunscreen is a must otherwise my face burns if I am out in the sun. One thing though, I face some acidity and take Pan D as prescribed by doctor, other than that nothing8
u/SnooGoats2271Smash next question6
u/basilsalmonshitI’m currently taking it. I’m so glad my dermat put me on it because nothing has worked for my cystic inflammatory acne. My acne wasn’t hormone induced so I was a perfect candidate for isotretinoin (according to my derm) Month 3 tomorrow. Started with 10mg for 20 days and 20mg for 40 days. I’ll start 30mg in 10 more days. I’m still breaking out although it’s wayyyyyy less intense. I had headaches for 5-6 days in the beginning but it’s been smooth sailing since then. Your post is giving me hope.6
u/ExaminationFail25Handsome af.6
u/RodrickJasperHeffleysean o pry who ? 🎵 I'll be your blonde tonight, if that's what you like Stilettos and fishnets, if that's what you like I'll be you 🎵6
u/ZenodorysDamn bro 🥀5
u/Working_Elevator_101Great results.  Ya man I also started it I did  20mg for 40 days,  30mg for 3 months,  Now currently doing 40mg for 4 months.  But the main issue is most docs in India prescribe you like this 5-20mg for one month then stop it and  use adapalene +benzoyl Peroxide. But isotret doesn't works if you don't take it's full cumulative dosage. Even I had to argue with my derm just to prescribe isotret full cumulative dosage. Isotretinoin is not even as bad as people think. People might drink alcohol, eat all the fried and oily stuff nd high carbs slop  for thier lifetime but still think that 1-2courses or isotret will nuke thier liver. It's insane4
u/ayako_qxmogger4
u/Affectionate_Form646i love u too yaar😞🙏🏻3
u/gutkeepsmeltingSyrianpsycho real id se aao 🔥3
u/Bet-ExoticDesi henry Cavill3
u/SnooGoats2271Daddy2
u/superlazypandaMan you're damn handsome. That jawline ufff, does it cut fruits?2
u/Zenodorys[deleted]1
u/AutoModeratorWarnings and Reminders To /u/Zenodorys Posting Rules + Ban Policy: Posting rules 4, 5, 7 and 8 are currently being enforced by members, not mods. Please report posts if you feel a need. All other sub rules are in effect. Refer sidebar, or view in full here. Please report rulebreaking comments. Offenders will be banned. To the Members Rx/medical advice policy is STRICTLY ENFORCED: Your peers will interpret your comments as expert recommendations. Therefore, ALL comments mentioning Rx products, giving opinions on a doctor's treatment plan, speculating visual diagnoses from photos, or any other borderline medical scope MUST INCLUDE EXPLICIT DISCLAIMERS. If in doubt, include disclaimer. If sharing anecdotal experience, include disclaimers. ERR ON THE SIDE OF CAUTION. BE MINDFUL OF THE SAFETY AND WELLBEING OF YOUR PEERS. BANS WILL BE ENFORCED FOR RECKLESS/POOR ADVICE. Spoilers: All image posts are automatically spoilered, out of consideration for fellow members. If spoiler is removed, use the trigger phrase "!spoilerthis " to respoiler the post yourself. Report posts with images unspoiled that show any part of a human (skin, hair, etc). I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.1
u/99problemsandfewI've just started it!  I'm having a bad acne breakout rn. Did you purge as well?1
u/Mimi_lunaIt's been only two months for me (currently on 20mg for a some time) I'm not getting new acne but the dark spots are bothering me a lot 🥲 when will these go away 😭😭1
u/HypeonthecloudWhat is ur skincare routine rn , r u using the tret cream version1
u/ZenodorysCould you show us the before image of yourself with this condition?1
u/Successful_Fan_9352On my 3rd month. I’m purging really bad. This is the worst my skin has ever been i literally hate looking at the mirror. Op is there any way to help the purge?1
u/cutebutpsycho30I’m on it too, but I’m also taking Wysolone, which causes acne. So this medicine and Wysolone kind of cancel each other out 😒1
u/pskin2020Post isotretinoin...what peel and other treatments you opted for1
u/kuposhitaJawline1
u/Legitimate_Matter695How did you get that jawline? Workout routine?1
u/Foreign_Sky_7903Isotretinoin does wonder to the skin. Only problem is when you have high cholesterol and that’s why I couldn’t continue with it for long1
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u/summerbreeze29I'm glad it worked for you and you didn't have any side effects but the "absolutely false" part is a little much imo. Your experiences are not universal.
u/akdakd1102Your results are excellent! It is, however, not false that Isotretinoin can cause increased liver readings, mess with mental health, is not safe for pregnancy, and cause side effects to joints etc. This is well recorded and studied. That doesn’t mean it happens to everyone. Obviously if the side effects happened to everybody it would not be approved for the market. These cautionary statements exist because it is a possibility, which is why medical supervision is required. I’m glad it worked for you, and you’re feeling good about yourself!
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140r/DandysWorld_RobloxCRAVEN! [MASTERPOST!foxyfan37_1987120%955.4regenerative medicine2026-03-24↗
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u/ExtentDue2588Could be good but also has a very high skill floor, maybe make the debuff just very minor (level 1) and make the potency buff only like 50%3
u/No_Treacle5533Does he have an indicator?2
u/PossibleMammoth5639When I see the word "masterpost" I glitter in fun1
u/theultimatetheifgigiGrace and Dandys world colab going brr1
u/MiludayooI'm sorry but at first I got reminded of this fella <image>1
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141r/pennystocksUpcoming penny stock catalysts for Q1/Q2 2026 in Biotech and PharmaAvish_Golakiya1020%4855.2regenerative medicine2026-03-10↗
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u/J0hnnyBlazer22
u/BasilWithWaterRCKT let's go!9
u/Avish_GolakiyaNot promoting this at all, just sharing my take since I’ve got an avg around $3.2 RCKT (KRESLADI) PDUFA Mar 28, now stock is around $5.24. Probably the cleanest high PoA setup on the calendar right now. Gene therapy for LAD-I, and it’s already doing that quiet, steady grind up. No crazy hype yet, just slowly building. 76% PoA is pretty strong, and these names often get front-run when the risk/reward looks this clean.9
u/Likes_The_ScotchWaiting for ELTP the swing back upward. It’s been floating around $.40 for too long now. Anywhere but up6
u/North_Welcome_3249Glad to see ATAI on there.5
u/thepoisonpoodleHow is PoA derived?4
u/Stitch426Avish, is there any update on MDAI? They submitted for FDA approval June 20253
u/RandyMarshFundYou are missing IronWood Pharmaceuticals2
u/Business_Mixture_139Srxh??? Reverse merger coming soon1
u/Competitive_Nail_159bhvn stock1
u/Get_rch_or_try_dyinThanks ! I bought a pile of RCKT the last few weeks. I’ve also got a large pile of IMRX . I think it has some huge potential through 2026 !1
u/MainDark3321No love for LPCN and their phase 3 PPD data readout coming in early April. They clarified that timeline in yesterday's press release for their annual report.1
u/Shot_Truth_5701Geovax GOVX- Bought in after last capital raise recently. Worth a look. <image>1
u/GreenSouth3SRXH1
u/OldTeaching8407Put this in a ETf basket would be dope1
u/StretchMinuteBREAKING: Check out SCNX-- on fire today. Just the beginning!1
u/iamWfdupWhat's the status on ALMS, and PVLA?1
u/Ordinary-Evening552Aldx high chances of approval today.1
u/darkknight-6Thanks for sharing. What are your thoughts on ALDX?1
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u/turnleftorrightblockTy.
u/Affectionate_Strain6INTS-1
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142r/KneeInjuriesGrade IV chrondromalacia patella. HELP.Tight_Imagination19440%3354.9stem cell therapy2026-03-18↗
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u/fireflysucks1Hi CMP Grade 4 here.. Took PRP Injection , i am too 33, doctor said this is the right age to took the injection. At first it was a relief but after a month or two the pain came back.5
u/RacacooonieConsider yourself lucky if not in pain. My chronic pain for five years led me to do MACI/TTO. I’d tried all conservative treatments and even surgery prior. This is helping, though, thankfully! Do you have a really great PT? I had to go private pay to get one that actually knows what she is talking about and has helped me in conjunction with my surgeon. There is hope. Keep working on it and advocating for yourself.3
u/idkman1768I had severe chondromalacia patella and had partial knee replacements in both knees3
u/StrictOrganization76Hola yo soy de España 50 años estoy con condromalacia rotuliana grado 4 con hueso expuesto y rótula alta ya an probado con una infiltracion de ácido hialuronico y dos de prp y sigo con más dolor después de todo, en junio me dicen cual es el próximo paso, alguien que aya pasado por lo mismo, muchas gracias por todo y fuerza a todos3
u/milobindiMight be a good candidate for MACI surgery if it is causing you pain in day to day activities. You could ask your ortho.2
u/Immediate-Lecture-20hi i have had grade 3 in one and grade 2 in another knee ans same age as you..my pain was healed with good consistent pt and then i later joined gym to strengthen my thigh muscles and stuff! That has made a lot of difference for me! I am not a fit person. so it still does pain every now and then if I push myself a bit. but it has improved for me. It took almost an year for me. let me know if any other questions2
u/jumaamubarakbitchesBe thankful it’s lateral and not medial. I’m 5 weeks into microfracture surgery with autocart on medial femoral condyle and I should be partial weight bearing by the end of next week despite my knee currently at 83 degrees. It’s not fun! At least lateral is not the weight bearing part of the knee. Silver lining.2
u/Sea_Perspective8729With this condition PT helps for the time being i dealt with these symptoms in my early 20s and yea I felt pain walking up stairs but just dealt with it.In my late 40s I ended up tearing my meniscus on the medial and lateral side of my right knee due to degenerative changes within my knee.Eventually I had my left knee replaced as I had grade IV chondro.So yea get a 2nd opinion and go from there. Good luck.2
u/HauntingAd1585Next step is going to be surgery. Theres no reversing it unfortunately1
u/StrictOrganization76From what I see, everyone with this type of injury ends up with a knee replacement; I have an appointment with my orthopedist in June.1
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143r/Podiatry"Regenerative Medicine" in PodiatryOldPod7320%8354.9regenerative medicine2026-03-19↗
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u/darken909I use PRP a lot in my practice. I see great results from it. SportVisc is getting popular in my area, a lot of sport med docs use it.12
u/SaltRharrisPodiatrist hate each other, in real life and online.12
u/Dramatic-Sock3737Glad you are amused. My brother does stem cells and PRP as a pain mgmt doc. Without him I would have needed rotator cuff sx. I have no problem with pods or other docs performing care that isn’t covered by insurance if they find it’s helping their patients.9
u/Dramatic-Sock3737You do you. Please don’t tell me or others how we should practice.9
u/1stMPJFuserIts the Cashification of medicine. Everything has to be treated with something special that costs $500+. They other day a patient came to me with an arthritic valgus ankle - they paid $3K for stems cells to a chiropractor. Did nothing. Another patient came in with bread and butter Achilles tendonitis. The problem was they were told it was torn, it wasn't, and that they'd need to start with $800 of shockwave. I wonder sometimes how doctors get patients to agree to these things, but now I know the answer. You offer nothing else. Its expensive treatment or cya. I think its tough to be a patient.8
u/ShiyuanDPMI’ll stick to my Tolcylen and low-dye strapping thank you very much. 😁6
u/azalin77I think the problem here is your passive aggressiveness ending your original post with snakes oil salesmen. I also highly doubt you "know" much about PRP or regenerative medicine because if you did, you would know it works. I'm one of the actual pioneers in this field as far as podiatry goes in NYC and can assure you it mostly works but you have to understand the pharmacologic and pathophysiological science of why you're using it and what you're using it for. I've used it extensively for nearly 25 years now both in the O.R. and in the office including BMAC/PRP/PPP/amnion/A2M as mono therapy and also in conjunction with HA injections and can assure you I have a 90+% success rate with it. Like anything else, though, it's not for everybody or every issue and I think that's the issue - when it's being marketed to patients to make a buck without understanding the biology behind it.6
u/DrTFPIt's all BS The key to success is taking stupid people's money legally4
u/Living-Protection250I get the frustration. There’s definitely a lot of noise around it right now. I think the tricky part is separating what’s promising vs what’s being marketed ahead of the evidence. Some patients are willing to pay for that “last option,” but the expectations and informed consent piece really matter. The business model shift is interesting too, but I agree it doesn’t automatically validate the treatment itself.2
u/Low-Conference-3762Anybody use PRF?1
u/OldPod73Another thing I find utterly amusing is that if I mention a statistic or number on this Sub, I get DESTROYED with "Where did you get those numbers!!???" Yet, no one is challenging anyone on here to present the numbers from a source other than themselves. It's hilariously ridiculous to me. Talk about confirmation bias...1
u/Critical-Ear-2478I have seen a lot of great results with other modalities that are not typically covered by insurance. Shockwave therapy, laser therapy, etc. PRP and amniotic injections are other great modalities, but I do not use those in my office. I think there is a place for anything.1
u/healthyfeetpodiatryI offer it but not as a first-line therapy. When you've done everything conservatively for certain issues, it's a great option before doing surgery which a lot of ppl don't want1
u/DrValentineDPMThis is such a great topic! I practice in Louisiana and I often use PRP for 2 key treatment protocols For plantar fasciitis I use a TOPAZ wand and then inject PRP after. It works very well. I no longer do EPFs. I use PRP as a treatment adjunct not as a sole line of treatment. This procedure is always done in the OR. So I bill insurance and not the patient directly. I do a similar procedure for Achilles tendonitis. I use the TOPAZ wand first then inject PRP after. - This has been a game changer. We all know how hard Achilles tendonitis is to treat! I hope this gives you some insight. You can definitely charge patient’s for PRP. Regardless of the science there is enough anecdotal information to support its usefulness. How you market is up to you 😉 Best, Dr. Valentine DPM- Foot and Ankle Specialist1
u/StewoveritNot sure what the point of this post is other than to troll. The minimal amount of counter evidence you provided in a comment can easily be rebutted by a quick Google search for articles that state the exact opposite. If you don't believe in it, don't do it. I don't provide these services simply because it wouldn't be worth it with my patient load. I'm curious as to why you consider yourself an expert in this area more than the countless practitioners who advocate and utilize these methods?1
u/SaintBobby_BarbarianLate to the party but PRP whether for injections or for wounds is a great tool with plenty of data backing it up. And organogenesis is getting a BLA approval done for osteoarthritis, with promising results. Then you also have stuff like shockwave therapy as another therapy option that has both reimbursable and cash pay options. Can you build a practice only on that? Not likely, but it’s another great segment to have
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144r/DDDInvestorsDDD x United Therapeutics: 3 Hours Ago on LinkedIn… They Just Pulled the “Moonsh...Imaginary_Weight6488120%754.6regenerative medicine2026-03-07↗
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u/PuckeringHole15k shares accumulated over the last two years with an average of around $2.30. I load under $3 because I believe in the tech, specifically this company, and I want to make a million dollars.3
u/ReactionOk9053Posts like this help build the narrative, but until an IND is filed it’s just talk.2
u/NoLengthiness3126Let’s start developing them! They might even be able to be delivered right to our front door like all the other Amazon items. ✌🏼👀1
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145r/DeadlockTheGameHero concept - TONIC - suppport hero with a chemist themebaldiplays100%854.3regenerative medicine2026-03-30↗
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u/1GameBoyMasterSo do the stacks disappear once you use your ult, or does it stay like Mina's ult with her bats?1
u/confidentlyfishПОНОС1
u/Usual-Lynx2362Honestly I think the roster could really use veteran/WW1/Government characters other than Haze and potentially Warden, whatever they do with him. Also could use more off-supports like Doorman. I think it'd be neat, like Ana from Overwatch able to boost allies and enemies with precision shots. Also remove Graves
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146r/InterstellarKineticsA 21-Year-Old New Yorker Became The First In The State Cured Of Sickle Cell Anem...InterstellarKinetics470%154.2stem cell therapy2026-04-03↗
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u/InterstellarKineticsThis is not the absolute first sickle cell cure. FDA-approved gene therapies have succeeded since late 2023, but it is New York’s first, and Beauzile’s symptom-free status after 21 years underscores the therapy’s impact. The real bottleneck now is not efficacy, but the $3 million price tag and manufacturing capacity. Bone marrow transplants were the prior “cure,” but donor scarcity limited them to Approximately 20% of patients. Lyfgenia uses the patient’s own cells, solving that entirely.3
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147r/STEW_ScTecEngWorldNewfound third cell type enables fully functional hair follicles in the labZee2A460%154.1regenerative medicine2026-03-05↗
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u/ZestycloseTowel2493Amazon link?2
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148r/4tran4One day, through science, my voice will be returned to me.New4taccount90%853.8regenerative medicine2026-03-08↗
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u/ufstdidkyjryrand how do you picture that happening1
u/Intelligent-Tea-2058FemLar VFS worked great for me. I'm starting to be able to sing again. I think I can get there pretty fully with more post-op voice training. Some of my friends got it recently, we'll see how they do... but I am hopeful. https://m.youtube.com/watch?v=75jKDGMW9-w It's much more extensive than other VFS methods. Basically "airway SRS." I really want to see it spread and developed more.1
u/hotobamasexLaryngeal framework surgery?1
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149r/ScienceOdyssey✨️ Japan is leading with policies around pluripotent stem cells, accelerating re...Purple_Dust57345710%353.6induced pluripotent stem cells2026-03-30↗
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u/Diawara57This is really exciting stuff! We've been hearing about the potential of stem cells for 3 decades or more now, and it seems like this is a huge breakthrough that can help many. Awesome!!positive4
u/messangerchknI dont trust capitalist medicine anymore. Cuba wouldve figured this out 40 years ago without the embargonegative1
u/Neil_HillistWhat could go wrong ? ... https://www.nejm.org/doi/full/10.1056/NEJMc1600188 ?neutral
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150r/physicaltherapyIs trying shockwave / hyperbaric / stem cell stuff actually worth it?Glittering_Seesaw_3250%1553.3stem cell therapy2026-03-22↗
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u/MindlessPromise5164nah save your money 💀11
u/sapionaturalI don't think there's any danger in trying shockwave, especially since the classic approach didn't work for you. No guarantee it'll work, but it may help restarting the healing process and increase your pain tolerance. Sure many physios here will disagree because of all the passive (and sometimes manual) modalities hate8
u/CommercialAnything30Hyperbaric is over rated unless your job relies on your Achilles. I researched this for someone not long ago and it requires 90 minutes a day for 12 weeks to get the benefit. Beyond that, no one knows the minimum requirement for maintenance beyond that initial protocol. Shockwave is worth it imo since you have tried everything else. Shockwave plus exercises.5
u/DrgnFly5[deleted]4
u/Ezdoesit1Anecdotal but I like shockwave for stubborn tendinopathies that are more chronic4
u/SentientScarecrowThere is some good research for it and it can't hurt to try if you have the money. I would also recommend you look into percutaneous needle tenotomy. If there's a provider in your area who offers it, I would recommend consulting with them. We see good results in treatment-resistant Achilles issues. ETA it's typically done by Ortho MDs4
u/OddScarcity9455No3
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u/halfserious3two years in with solid pt means the fundamentals are there. shockwave has legit research but the real issue is usually how people ramp back up, not the tissue itself. most get the same result from being way more conservative with the progression and that's free.2
u/VO2VCO2Since it's lasted so long I would try combining few Shockwave treatments with heavy resistance exercise. Did you actually go hard with the exercises for an extended period of time? Skip on the other two. Placebo effect at best but small chance of serious consequenses = skip.2
u/Living-Protection250I think most people I’ve seen in that situation end up realizing it’s less about finding the “next thing” and more about how well the loading and progression actually sticks long term. Some of those options do get used, but from conversations I’ve had, they seem to work best as an adjunct, not a replacement for a solid, consistent loading plan. Otherwise it’s easy to get temporary relief without real carryover. You’re definitely not overthinking it though, chronic tendinopathy can be frustratingly slow and non-linear. Curious what others here have actually seen move the needle in these stubborn cases.1
u/1giftedangelShockwave has produced results in myself and others.1
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151r/HubermanLabLongevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran130%453.2regenerative medicine2026-03-22↗
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u/BioMIR_1221Try BioMIR app from the app store for daily computation of biological age based on 15+ biomarker inputs from wearables and home-based devices. It also computes KDM and Levine phenoAge based on episodic clinical bloodwork. We can’t modify what we can’t measure. Lifestyle prescription without observability is mere opinion. Self-experimentation begins with proper instrumentation.1
u/midnight-on-the-sunI was just diagnosed with borderline LPa, 85 and PTau, 2 points over normal. No disease in family history. Genetic high hdl.1
u/That_random_momQuest Labs uses the following on APOB, are you suggesting it should be lower than the recommended guidelines from my lab? I am APOB 3/4 with a result of 86. Currently have lowered my LDL 30 points with lifestyle interventions and still on the downward trend.  "APOLIPOPROTEIN B Unit of Measure: mg/dL 86 Reference Range: <90 Risk Category: Optimal <90 Moderate 90-129 High > or = 130 A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient including patients on lipid lowering therapies, patients with ASCVD, diabetes with >1 risk factors, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020."1
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152r/OptimistsUniteStem Cell Therapies "Come of Age" with Approvals in JapanCrabbexx340%52.8induced pluripotent stem cells2026-03-12↗
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153r/ApoE4Longevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran140%352.5regenerative medicine2026-03-22↗
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u/eddyg987Resovastatin does cross the bbb. ApoA1 can cross the bbb and can integrate itself onto an ldl particles thus making it them less dysfunctional. So hdl does matter for apoe4 carriers further evidence of this is the data from the ocetrapib phase 2 study that showed 20% less plaque formation. They(the authors of the study) claim direct obecetrapib interaction, but that’s wrong it’s the huge increase in apo a1 caused by the cetp inhibition.3
u/CantaloupeNo3975Is this the study referenced? If so, it looks like the participants with HMGCR SNPs had an average blood ldl of around 130mg/dl. Am I reading this correctly?1
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154r/webdesignI just redesigned a hair restoration landing page..... is this good ?codes_swalih380%7552.4PRP knee treatment2026-04-02↗
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u/DunkingTeaColours are ok. Check contrast (particularly for the text at bottom middle). New one doesn’t really give off anything to do with hair/hairline. Image would be better updated to be close up of head, or comparison slider showing before and after in an animation.22
u/Successful-Escape-74Need a guy with hair on your hero page. That's a high hairline.19
u/jjjjjjojjjjjjIgnore the haters who are being obtuse. There is no conceivable way the before is better. The new design is aestheticlly very nice and conveys more information while still looking cleaner. My suggestions would be to improve the legibility/contrast of the lower text, and I would personally have the teal background full width/height, removing the white framing. But honestly a great job7
u/Stunning-Usual-6693I liked before option. Sincerely I do not like site where owner is the major part of it.. just my opinion. However, colors and fonts and everything looks great on new landing page..5
u/JJE1984What's it look like on mobile? It's where most of the traffic will be?3
u/TumbleweedOk7307Honestly really good but the only comment I’ll give you is that hero section photo kinda have a receding hairline… a bit counterintuitive to what thw business is3
u/madcodezHeader nav(links) isn't centred.2
u/otrdtrYour version is way more impactful. Maybe the photo could be more interesting.2
u/Unlucky_Quote6394The new version looks so much better! For the hero section I think it’d make sense to have a background image (maybe a blurred photo of the clinic) with the owner in focus on top of that image. With just the owner and a green background it looks a bit empty2
u/lemonsnakcOut of curiosity, did you use ai to make this?1
u/Main-Lifeguard-6739depends... did the target group change from middle aged men to young woman?1
u/sf8asChalk and cheese mate. The new design is much better. Perhaps instead of showing the doctor, show a before and after.1
u/Bitter-Arachnid-5194That guy shouldn’t be on hero definitely1
u/Kevin_fartAny design for architure or structural engineering1
u/codes_swalih[deleted]1
u/BNfreelanceYou took it from boutique/chic/local business to fully fledged commercial service - I approve I’d sprinkle in some more hair1
u/Impossible_Many_2823looks actually nice, could you share the website?1
u/No-Praline8782I like the direction of the new site, but old one visually conveys “hair…” better. If I don’t read the header I’d have no idea this site has anything to do with hair. I get it the owner but, it doesn’t make it the best choice in my opinion.1
u/wildmfz561I think the dude needs a black rectangle behind him or something. Dark blue doesn't go well with that green color. But his photo itself isn't a good example for hairline growth. Also the white frame looks yellowish? doesn't match other white elements. There's way too many different colors in general. Two shades of white. A green color, blue color, black. Try sticking to 3.1
u/parkerprojectWas this vibe design?1
u/parkerprojectWhy not?1
u/sureshsanghviYes Absolutely better than that and would like to know the steps you follow.1
u/kg-060215I really like your new hero, the new colour feel better than the before, more contrast with the text. I like that you put up the picture of Dr Charlie, it creates a sense of trust for me, that "heyy, he looks like a good doctor". Also like that you sticked with one main CTA this time for contacting. Thank you for taking out that long nav bar and putting everything under services, and for putting the snapshots of reviews, the types of hair services and results his customers get, I feel its a solid hero, and would urge me to continue scrolling, or if I w.as looking for this type of service, book a consultation1
u/Prestigious-Can1696Bro its looks great. colors, symmetry everything is good. Just one recommendation from my side you can try adding some visual elements like illustration etc that tell the brand story more clearly. By first look people should know what it is for. Apart from that everything is good 👏🏻.1
u/dead_toyouold site with the updated header be perfect. looks more elegant and less "corportate"1
u/vi_whoNice, now it looks like a good ai slop webdesign
u/CentrezBefore is better-1
u/NiteKore080i thought they were swapped the after looks good but very generic and off putting. you know that feeling you get when you see advertisements? the red flag feeling where you try to avoid advertisements and viruses? that's what its giving the before feels a lot better, natural and fits the theme. the hair and comb background admittedly does a lot of the heavy lifting i didnt look at any other details. those are my very raw, initial thoughts and feelings-2
u/Money-Relation3640The before looks way better-4
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155r/ParkinsonsTruStem cell therapyAware-Drawing-542680%652.4induced pluripotent stem cells2026-03-13↗
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u/Ill-Lavishness4274Look, the stem cells showing promise in PD trials right now are very different from what these clinics offer. The real work being done by real biotech companies like BlueRock, Sumitomo, and Aspen involves specialized cells that require serious neurosurgery to reach the right part of the brain. Clinics like TruStem just do basic infusions, which have no evidence behind them for Parkinson's. I know the current trials exclude DBS patients, but that’s standard for testing (they exclude lots of stuff like diabetes or psoriasis even). It doesn't mean the therapy won't be available to you once it’s approved. Things are moving fast, so please don't risk it with these shady clinics. They aren't a shortcut, they’re just a distraction from the real science.positive12
u/Intelligent-Will-913I read somewhere that Japan is rolling out stem cell technology in the summertime for those with Parkinson’s..neutral5
u/IllustriousTonight82Last year I watched a webinar with several scientists on michaeljfox.org that discussed this at length. As Ill-Lavishness4274 said in their post, there is no evidence that stem cell infusions are effective treatments for PD. True stem cell therapy that is being studied in clinical trials involves brain surgery.neutral5
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156r/NightLordsUpdate to my warbandJohn_Maynor_1380%652.4regenerative medicine2026-03-20↗
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u/Ok-Food-7548I don’t know much about NL but I like it2
u/lsdjowThis is really cool , do you have any kitbashed models for them yet?2
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157r/Neet_indianeed help w this questionIcy_Money496150%1152.3induced pluripotent stem cells2026-03-14↗
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u/SquirrelEconomy5315B hi toh ayega polar movement toh light ki presence mai hoti hai, online search karo iske bare mai image se samajh aa jayeganeutral3
u/Majestic-Concert6634a is the answer. the movement of auxin to cut side leads to its isolationneutral3
u/CapSensitive5509I think it should be A, as the movements were recorded by Darwin and his son, while this guy isolated auxins from tips of oat seedling or smthneutral2
u/takli_billiI think d, explanation for b? ?negative1
u/[deleted]Bneutral1
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158r/WeLoveYouCaineAm I Crazy or Alone?OriginalHell100%452.0induced pluripotent stem cells2026-03-26↗
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u/Maximum_Effective66it’s too late for my brain to process all of this, but get into it /gen /pospositive6
u/ZealousidealDrop365Holy yapfest (I say that lovingly)positive5
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159r/diabetes_t1Question for people living in countries with free healthcaren - do you think ste...Virtual-Medium-589140%1251.6stem cell therapy2026-04-01↗
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u/ben_jamin_hStem cell therapy would become free in countries with healthcare when the cost of the treatment becomes equal to or less than the cost of insulin treatment, or when the people in charge of the healthcare budget decide that the benefits are worth the cost. They would probably prioritise children and pregnant women at first, and then younger adults, and then middle aged adults, and then older adults, as the young would live a longer life without relying on insulin therapy... So whenever it does happen I'll be way down the list 😂 If stem cell therapy is scaled and prices go down, it might be possible one day. It would all depend on the cost.10
u/amanset[deleted]5
u/anti-sugar_dependantDepends on how well it works I think. The NHS, well NICE, requires evidence that a new treatment is worth the cost. So the reason all T1Ds now automatically qualify for a CGM in England is that NICE looked at the evidence and decided that it's cost effective to give all T1Ds a CGM because it enables better control, which reduces complications, which cost a lot of money. Basically the same reasoning for why we get free prescriptions. So if stem cell treatment works out cheaper than treatment with a hybrid closed loop, taking into account all the long term effects, that's probably what they'll do. And if it's not cheaper they'll probably stick with HCLs.3
u/DamnknitI don’t think it would be free. Maybe eventually but definitely not at first. We don’t have to pay to go to the doctor or hospital but we still have to pay for all prescriptions including insulin and CGMs. There’s government programs that can help but don’t cover the whole cost. It’s significantly less than somewhere like the US but some medications are still very expensive unless2
u/YlsaniLikely yes but probably 10-15 years if not more after it's approved.1
u/Chance-Ask7675Of course. It will follow the same trajectory as every other drug or treatment that comes to market. And that very rarely includes an expectation to pay out of pocket in places with socialized healthcare. First it will be experimental, then covered for priority groups, then more widely available. Drug companies price drugs with this in mind and negotiate with healthcare authorities, they dont just set the price at a million dollars and say "too bad, you dont pay no one gets access" lol. They'd never get anywhere if it was only available to rich people willing to pay out of pocket and doctors wont waste their time learning the necessary protocols if thats their patient pool.1
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160r/HFY[The Lord of Silvershade] - Chapter 7: Point BlankZinthorr50%851.3regenerative medicine2026-04-01↗
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u/Zinthorr02:00 PM - The First Lift Noah consumed a piece of Mana-Sage tea to keep himself upright. He focused on the trench. He pulled the earth upward, flowing it into the space he'd cleared. Because he was Level 7, the earth felt more like clay in his hands, more responsive. [MANA: 100 -> 10] (Regen included) Slowly, a new wall began to rise. It wasn’t 10 feet yet, it was a 3-foot-high, thick, dark-grey "stub" that traced the 70x70 line. It looked like a scar across the forest floor. 05:00 PM - The Exposed Bailey Noah was physically and magically exhausted. The 30x30 inner fort stood behind him, safe and spiked. But he was now standing in the "Bailey", the 20-foot wide gap between the old wall and the new, unfinished one. "Noah," Cortana warned. "You are at 10 Mana. The new wall is only a low barricade. If the Bear was still alive, he'd step over this without slowing down. We are officially in the 'Danger Zone' of construction." Annastasia stood at the inner gate, leaning on her new Cold Steel Longsword. She looked out at the deepening shadows of the forest. The violet light was fading into a murky indigo. "The forest feels our work, Noah," she said, her voice low and warrior-sharp. "The birds have gone silent. Something is watching the new line." Miya was up in the Sentinel Spire, her eyes darting across the landscape. "I see eyes!" she called down. "Small ones. Many of them. Not bears... Skulkers. They know you are drained." [DAY 14 PROGRESS] Foundation: 100% Complete. Wall Height: 3ft / 10ft. Mana: 12 / 200. The Evening Crisis: The pack of Skulkers, perhaps twenty of them, led by a larger Alpha, circled the new 70x70 perimeter. They hadn't crossed the 3-foot "stub" wall yet, but they were testing it. "Everyone, back to the Citadel! Move!" Noah didn't wait to see if they followed. He grabbed Nugget by his scruff, ignoring his indignant chitter, and ushered Miya and Anna through the gap in the inner 30x30 spike-wall. Anna moved with a grim, focused efficiency, her hand tight on the hilt of the Cold Steel longsword. Once everyone was inside, Noah slid the heavy Ironbark-reinforced earth slab shut. Clack-thud. The Citadel was sealed. They were safe behind six feet of petrified earth and a forest of Ironbark spikes. "Miya, watch the gate. Anna, stay near the lodge," Noah commanded, his voice raspy from the day's labor. He scrambled up the spiral stairs of the Sentinel Spire. His legs felt like lead, and his vision swam with the "Mana-Ache," but as he reached the top and rested the Savage Axis on the parapet, the world narrowed down to the crosshairs. Outside, the Skulkers had crossed the 3-foot "stub" wall. They were in his Bailey, sniffing at the freshly turned soil of the garden and the iron ore in the pit. The Alpha, a lean, scarred beast the size of a mountain lion, stood atop the pile of iron ore, letting out a series of sharp, clicking barks. It was a call to the pack to begin the feast. "Target locked," Cortana whispered. "Distance: 25 yards. High angle. Noah, you're shaking. Take a breath. Hold it. Squeeze." CRACK-BOOM. The .308 muzzle flash lit up the twilight. The bullet caught a Skulker right as it was about to bite into a zucchini vine. The creature was tossed backward, its chest cavity collapsing from the impact of the soft-point round. The pack froze. They looked at their fallen comrade, then up at the tower. CRACK-BOOM. The second shot took another Skulker near the well. It didn't even scream; it just dropped into the mud. The Alpha snarled, its hackles rising. It looked up at him, baring its needle-like teeth. It seemed to be weighing its hunger against the "Lightning-Staff" in the tower. Noah lined up the vertical line of the reticle right between its glowing amber eyes. He didn't fire. He just waited. "Psychological warfare, Noah," Cortana said. "Let him feel the scope on his brain." The Alpha blinked. It let out a frustrated, low-frequency hiss and turned, leaping back over the 3-foot outer wall into the safety of the deep violet ferns. The rest of the pack followed suit, a chaotic scramble of grey fur and clicking tails. [THREAT NEUTRALIZED: PACK DISPERSED] [XP GAINED: 60] [LEVEL 7: 610/800 XP] [AMMO CHECK: 29 ROUNDS REMAINING] Status: Mana: 15 / 200 (Regenerating). Stamina: 15 / 210 (Severely Exhausted). Balance: $345.00. Noah let out a long, shaky breath and leaned his forehead against the cold earth of the battlement. "That should keep them at bay for the night," Cortana said. "But they'll be back. They saw the 'weakness' of the outer line. We need to finish that wall tomorrow, Noah. No more distractions." He climbed down the stairs. Miya was waiting at the bottom, looking up at him with a mix of concern and admiration. "The lightning spoke," she said softly. "The garden is safe. For tonight." Anna was sitting on the porch of the lodge, the Cold Steel blade resting across her lap. She looked at the rifle in his hand. "A warrior who can strike from the he4
u/HFYWaffle/u/Zinthorr has posted 6 other stories, including: [The Lord of Silvershade] - Chapter 6: The Broken Blade [The Lord of Silvershade] - Chapter 5: Roots in the Violet Clay [The Lord of Silvershade] - Chapter 4: Foundations [The Lord of Silvershade] - Chapter 3: The Spark and the Steel [The Lord of Silvershade] - Chapter 2: Building the Lighthouse [The Lord of Silvershade] - Chapter 1: Four Hundred Square Feet of Order This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.1
u/UpdateMeBotClick here to subscribe to u/Zinthorr and receive a message every time they post. Info Request Update Your Updates Feedback1
u/GumGodGamingGood part well done Wordsmith You may want to pin the comment part so it stays at the top (I think Reddit lets you do that?) ... with sort by best on the bots are before it1
u/GrimkytelYou've got a couple repeated paragraphs in the Day 14 Agenda section. Looks like you were correcting/ tweaking and didn't clean things up correctly.1
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161r/ParkinsonsTV Report on Kenai's Stem Cell Trial in LAIll-Lavishness4274140%251.2stem cell therapy2026-03-27↗
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u/OneWingedJokerLove your posts. Particularly as an EOPD lottery winner, keeping a hopeful eye on the future definitely helps. Thanks for these updates!3
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162r/KneeInjuriesMy experience with Chondromalacia patella-ouT--70%551.2PRP knee treatment2026-03-13↗
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u/mynameisnotearlitsEnvelope of Function- Scott Dye2
u/RemoveOk628Hey, happy to hear you're better now! I'm dealing with knee pain as well and sitting for a long time at work is really painful... Did you experience the same ?1
u/BSBorthoOur average knee PRP patient reports 5% improvement at 1 month, 30% at 2 months, 60% at 3 months, and 80% at 4 months. Not sure if this fits your timeline. Either way glad the combination of PRO and Exercises did the trick.1
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163r/InterstellarKineticsSildenafil, The Active Ingredient In Viagra, Has Just Slowed A Deadly Childhood ...InterstellarKinetics100%351.1induced pluripotent stem cells2026-03-31↗
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u/InterstellarKineticsTurning an erectile‑dysfunction drug into a life‑extending therapy for dying children is the kind of “repurposing” story that will resonate strongly with a general audience. The key detail to emphasize in comments is that sildenafil does not cure Leigh syndrome. What it appears to do is buy time and function by partially rescuing energy metabolism in neurons, giving affected kids more mobility, fewer seizures, and relief from the terrifying metabolic crises that can suddenly worsen the disease. That is still a massive change when the baseline is rapid neurodegeneration and early death. The orphan‑drug status and the planned SIMPATHIC trial are the concrete follow‑up milestones that will determine whether this becomes a standard treatment or remains a promising but niche intervention.positive1
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164r/covidlonghaulersThrone Biotechnologies stem-cell educator therapy for LCsaintmars77780%451.0stem cell therapy2026-03-06↗
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u/Many-Market-9941This is the kind of conversations we should be having on this sub! We have spent enough years speaking about supplements, mind body work, or even medications like LDN, which can provide relief to some but are not the solution we need to ‘nuke’ this syndrome for once and for all2
u/berryenthusiastI'm in the process of sending them my information. They're done with trials it's now considered treatment. I was hyped about it until they sent me this: "Payment in full for treatment is due before or upon your arrival the day prior to your first scheduled treatment. At this time, the charge for the first treatment is $39,000. If you elect for the follow-up treatment 8-14 days after the first treatment, the charge for that is an additional $10,000. Payment should be made by wire transfer. Wire transfer instructions will be provided" https://patients.thronebio.com/further-details-of-thrones-stem-cell-treatment-for-autoimmunity/ I also can't find any testimonials. So. I'm a bit disappointed.2
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165r/beginnerrunningKnee pain: causes and treatment?LiedvonderErd340%1051.0PRP knee treatment2026-03-16↗
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u/BisonThunderclapIt's time to stop running and walk right now. The fact that this pain persists outside running means you should take it seriously. You don't get a lot of leeway with ligaments, especially in the knee. Get it checked out by your doctor, because you don't want to fuck your knees up for life because of someone online confidently telling you "it's probably just an overuse injury." Read this part after the doctors: assuming it's nothing serious, this looks like something Id expect out of worn down shoes or ones that aren't right for your gait. Also, with the extra weight you currently have, I'd caution you avoid road and sidewalk running until you're down a bit in weight, that's a lot of pressure to put on cartilage. If you're dying to work out hardcore until then go swimming as a low impact solution for the joints.9
u/Educational-Train-92I'm f32 started running at almost 130kgs and 5' 11. I would recommend weight lifting to build muscle tone, yoga to make sure you're stretching properly I just follow yogabyadriene on youtube at home she has a lot of 30 day courses and seeing a podiatrist to make sure your shoe fit is correct. Also don't go from 0-100 your body needs to build up muscle tone. I have terrible knees though they're both hypermobile and have arthritis in them and since building muscle tone I have no pain with my running. I have a personal trainer and a physiotherapist I see occasionally too.4
u/GritGrinderSeems like where your MCL is. You might need to cool it a bit and work on your running mechanics while caring for your joints and staying hydrated etc2
u/Accomplished-Role835I really would wait a little longer and focus on walking for now. Walking is still a great exercise and I did it a lot while postpartum with all 3 of my babies. In my experience, I’ve found it takes a little while for your body to get back to baseline. You spent nine months with your body stretching to accommodate your baby and it’s going to take some time for your body to readjust. You will be able to run eventually, but for now, give your body some grace. :)2
u/Soldado_a_TraderCreo que si ya que cuando alimentas a tu bebé le estás proporcionando los nutrientes más puros de tu cuerpo, yo creo que sería mejor que realizaras únicamente caminata en lo que alimentas a tu bebé, y ya después empieces con un trote suave y lo incrementes poco a poco. Pero lo ideal que consultes a un especialista
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166r/TrenchCrusadeBuilding my first warbandMurky_Reception_553440%950.7regenerative medicine2026-03-23↗
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u/Random_Guy_BenStandard game size is usually 800/6 or 900/8. However for your first few games i would recommend to start with 700/0.4
u/KallandrasWelcome to the hobby. Seing that you are an absolute beginner, I wanted to drop some advice on listbuilding in general before talking about sultanate and your list. You can also always ignore good listbuilding and just play models that you think is cool, but then you should really not ask around what you should play but ask only yourself and play what you like. But if you want to build effective warbands, here is some basic advice: More units, more good: In all but one subfaction, more units are better and it is universally accepted to use the campaign unit limts as the maximum that is allowed (10 units at 700 ducats and +1 for each additional 100 ducats, glory does not matter). Especially at higher points, so starting 900 and some glory or at least 1000 it should be possible to hit that unit limit. The reason is that it is terrible to pass when your enemy still has 4 units left and can do stuff without you interceding. That also often means that you have to activate your good units before the enemies juicy targets are out of cover and you waste their activation. On top trench cursade is a game about objectives, so you want to spread and have enough units to sit on those while other units try to kill the enemy. To translate this to listbuilding, you want some powerfull elites or mid tier units and fill up with models that are as cheap as possible while still having the chance to do something (wretched and prisoners are fine if they just exist without being able to do more then sit on objectives, they are that cheap). Gear your units so that whatever they do, its done at least at +0 dice, +1 if possible, never at -1. So dont give models with negative ranged stats good ranged weapons. As ranged attacks are most often made vs. cover and often at long range, most of the time you will have a -1 or -2 modifier to your ranged attacks, so even on a +1range model, you really want a ranged weapon that ignores cover, long range malus or gives you +1 to range, more so on a +0 range model. This is why bolt action rifles are not good on +0 range models if you can use a shotgun or a grenade instead. The rifle has more range, but you will not hit anything above 12 inches and below that the other weapons are better. It is also a waste to give a second melee weapon to a +0 melee stat model most of the time. Dont just think about how good your melee and short range units are if the connect, also think about how they can make it to the enemy in the first place. Especially melee units need to dash to make it to melee unless the enemy randomly pops up within 12 inches of you and does not hit you first. So normal 6 inches movement models without a dash bonus that just want to go melee are normally bad, would need to be outrageously tanky and hit hard to make them good. Similiar for very short ranged ranged units. Infiltration can make up for those short range units, as they can use their normal move to move into shooting range, melee units have to use their dash to move into charging range (which is a risky action so you pass your turn 42% of the time). A musical instrument is the best equipment in the game, it goes in every warband. Dash is the most important thing you do in trench crusade. It is basically required for melee untis, but its also amazing to move, shoot and dash back out of sight or simply to take objectives or shoot and dash out of melee range. Every melee unit should have a ranged assault weapon unless they have negative ranged stats. That often is a grenade. 95% of models with a ranged weapon do not need a grenade on top, only if your range weapon does not have assault and your main gameplan is melee (or the grenade is a satchel charge). You need armor breaking weapons, relying on bloodbaths to break armor is not as effective. So bring some solutions here. Starting at -2 armor, normal attacks will not cut it to kill within a reasonable time. Helmets, gas masks and so on are only worth it on tough and highly armored units. The reason is that unarmored units will die with or without the additional blood, so gearing them with an item that is inherently situational is bad. Its always better to stack defences on one model. About sultanate, currently they suck hard, only the house of wisdom is a little ray of hope. One reason is that they dont have good weapons for their elites and since the 1.0 rules changes, ranged based armies in general got weaker as you do not gain +1 to injury on downed models at range anymore, which is very significant for bloodbaths. However, (non scatter) blast and automatic ranged weapons got huge buffs and sultanate just does not have those or no good carriers. Their theme is single target ranged weapons (jezzails) and those are outperformed by grenades and their siege jezzail is too expensive. House of wisdom however can steal actually good weapons from other factions and have the one model where MURAD bombards are actually good on, the homunculus (bull has too low of a ranged sta4
u/OpIvy1137For your first game, I always recommend starting small. 700 ducats is the biggest game size I ever recommend for first games, and even say that 500 is better. The smaller the list the easier it is and generally less complex your list will be, so you can focus on learning/mastering the base rules of the game and less on the thousand individual rules of each piece of battlekit. An easy way to make a starter list is to just use the models that come in the starter warband bundles. Then give them some decent equipment, and boom basic list at 700 ducats. Also looking at your list real quick, I just wanted to note that unless you and your opponent agree ahead of time, you cannot bring trench dogs or any of the campaign glory items to a one off game. They are campaign specific. It's a new change to trench crusade, and some people miss that rule.1
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167r/regenerativemedicineStem cells saved my wife's lifeInventoman390%950.6subreddit:regenerativemedicine2019-12-04↗
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u/toomuchbasalgangliaThat's awesome to hear. Congratulations. It made a world of difference for my pain issues. I swear it would have been cheaper for the insurance company to have paid for the stem cells than all of the treatment they would have had to cover.5
u/clewis2015What an awesome post! I'm glad that stem cell therapy worked so well with your wife. I reside in Thousand Oaks, CA and we have an office that offers regenerative medicine - stem cell therapy treatment (Infinite Regeneration Medical Group - 805-975-8223). We have many patients that have improved their quality of life due to pain relief and many more.2
u/InventomanWhere did they inject? Into the thyroid itself? What place did you go to? Ty!!!1
u/Carlos2031Thank you for your testimony. I am anesthesiologist in Spain. Did they expand/multiply the cells for days or was the extraction and application the same day?1
u/Prestigious_Oil9859Amazing!1
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168r/ATHXJapan officially becomes the first country in the world to approve iPS cell-deri...imz7250%650.3induced pluripotent stem cells2026-03-06↗
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u/imz72Japan approves world‑first iPS cell drugs for summer release March 6, 2026 Japan has formally approved the world’s first regenerative medical products utilizing induced pluripotent stem (iPS) cells, paving the way for use in patients as early as this summer. Health Minister Kenichiro Ueno granted approval for the two products on March 6 under a fast-track provisional certification system. They mark the world’s first practical use of medical treatments derived from iPS cells. The approved drugs are ReHeart, developed by the Osaka University–originated venture Cuorips Inc., for the treatment of severe heart failure, and Amchepry, a neural cell therapy, developed by Sumitomo Pharma Co., for the treatment of Parkinson’s disease. Both products use third‑party iPS cells stocked by the CiRA Foundation, which was established by Kyoto University. With the drugs now approved, prices will be set and will be authorized for use in treatments covered by the national health insurance system. For regenerative medical products, drug prices are generally determined within four to five months after approval. The treatments using these drugs could be available for patients as early as this summer. Both products were approved under the conditional and time‑limited approval system, which is designed to deliver regenerative medical products to patients as quickly as possible. This system is a kind of provisional license, allowing safety and efficacy to be assessed using data from fewer patients than is required for clinical trials of conventional drugs. For this reason, companies are required to study treatment outcomes during the seven‑year period following the start of sales and obtain “full approval” after reassessing efficacy and other factors. ReHeart will be assessed under the treatment of 75 patients and Amchepry for 35 patients, including 30 who are 65 or younger. The clinical outcomes of all patients who are treated using these products will be examined. The iPS cell was created by Shinya Yamanaka, a professor at Kyoto University, who received the Nobel Prize in Physiology or Medicine in 2012 for his groundbreaking work with iPS cells. This year marks the 20th anniversary since Yamanaka first generated iPS cells using mice in 2006. [Source: The Asahi Shimbun] Health Minister Ueno Kenichiro said after a Cabinet meeting on Friday that he hopes patients in Japan and throughout the world will be helped. He added that the necessary procedures will be moved forward so the treatments can quickly reach all patients. https://www3.nhk.or.jp/nhkworld/en/news/20260306_17/positive1
u/wood999999I see your still around. Grahamneutral1
u/AutoModeratorPlease report any rule breaking posts and comments that are not relevant to the thread. Thanks !! I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral
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169r/stemcellsOut of curiosity: knee pain treatmentComfortable-Fox-566120%1950.1PRP knee treatment2026-03-25↗
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u/InnominaAnatomicaThere was recently a great discovery. Inhibition of the 15-PGDH increases PGE2 which causes cartilage to regenerate as hialine cartilage. In mouse of course. Im a researcher and im trying to get to do an experiment on dogs (pet dogs with severe arthrosis), as a mid step. The other day speaking with a traumatologist, she was really interested, so maybe in a couple years we could try this on humans… Do what you need, but if i could, id wait for 2 or 3 years.5
u/brockloisl456another chatGPT generated scam post by this user who seems to be pushing the same shitty clinics in every post he makes4
u/Cissylyn55Look into prp2
u/jonnychimpooWhat kind of injury are you dealing with ?2
u/Ryan_MedConsultantTotally understand the hesitation. From what I’ve heard after asking doctors, some regenerative knee treatments have been used for years in China and aren’t necessarily considered “new” there. That said, outcomes still seem to depend a lot on the exact diagnosis, imaging findings, the doctor’s experience, and whether the case is actually a good fit. If it were me, I’d want a very clear explanation of what problem is being treated, what the realistic outcome is, and at what point surgery becomes the better option.2
u/Bodigaron1981If you have access to an orthopedic surgeon specialized on stem cell therapy I would ask him directly with your medical reports and imaging. If you don’t have one I can get the feedback from one of them for you1
u/ThanosFishermanBro what kind of surgery? What's the diagnosis?1
u/Extension_Move1094I would give stem cells a try for sure. My knees have improved so much after 25 million injected into each knee. Also, research walking backward. For me? I would do anything to avoid knee replacement surgery seeing all My friends with mixed results. With arthritis, you can’t wait until it’s the worst stage and expect SCs to help however. Better to do it sooner. I would recommend talking to Dr. Ivan at the Carabella Clinic in Tijuana and go from there.1
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170r/FuturologyIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz0%4549.9regenerative medicine2026-03-10↗
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u/kore_nametooshortIf aging ended, we would continue to die due to disease and accident. I vaguely remember reading a study that said average life expectancy in the western world would be about 1200 if that happened, but it would be more like a half life where you'd expect half the population to die in that period rather than people to live about that long, give or take. So reproduction would be necessary, but to a much lesser degree. This would probably lead to restrictions, but not bans. Something like a stricter version of the China one child policy, or severe devaluation of human life allowing countries like russia to throw lives away in wars much more readily. It might also coincide with higher productivity because you would change from having only about 62% of the population being working age to probably the high 90%s. And many fewer of those dedicated to caring, education for the very old or young. You would need this to bring in more food, energy and housing for all the people.17
u/CTRexPopeThey likely won’t need too. Birth rates are already falling globally. Give people time to put off kids for decades if not centuries, enough will opt in and die from random accidents to control the population level.9
u/malk600Cool, cool. Let's start with the obvious. We're not going to "cure aging", and certainly not within 20 years. People who claim that are misinformed or selling you fancy snake oil. Long term? Who the hell knows. I kind of like to imagine a Star Trek or Lancer-like future (or even Expanse, though that's not exactly optimistic), where space is the frontier that calls for humanity to fill it, but the path from here to there is fraught at best.6
u/orgin_orgAny such cure would probably entail obscenely expensive RNA treatments that are specifically tailored to an individuals own DNA and cellular makeup and not a generic treatment that works out of the box on anyone. So only very rich people would be able to afford it. That is, the adoption would be very slow so any population regulation would be very far down the line.5
u/GerdioneI think quite simply no. If the only part of your hypothetical is that they cure aging, then it just means that only the obscenely extremely wealthy and connected will have access to it thereby cementing their legacies and power. Why would they make it accessible to poor people? Insurance already tries to cover nothing, imagine arguing why you need to stop biologically aging.5
u/WaboritafanThere is a Kurt Vonnegut story that tackles this subject. A man and his wife have triplets on the way. They must find 3 people willing to die voluntarily so the babies can live. Or the babies will be euthanized.3
u/Aggressive-Fee5306"Fill out a C-01 permit before engaging in any activity that may lead to reproduction." Doubt it though, to governments it means more taxpayers and to businesses cheaper labour. There is no concept of "okay, 100 billion is enough"2
u/IndigoFenixYou're forgetting about the cost of raising a child. Populations don't grow without limit, they are restricted by the available resources, which is abstracted as money. If immortality becomes cheap and available, what is most likely to happen is that the paradigm of "once a child is born, someone has to support them" will fall out of favor, and that the cost of supporting a child will fall on the parents. If parents have more children than they can afford, those children will simply die. It seems cruel, but what's the alternative - artificially preventing most people from having access to immortality treatment? That's the same as letting everyone die when they don't need to. Try that, and you've turned the minority restricting the supply into a target for literally everyone else. Provide easy access to both birth control AND cheap immortality, and people who decide in spite of this to have children they can't afford will become the target instead. That's a minority that is much easier to condemn.2
u/fafarexIt raises some strange questions: Would reproduction become illegal in an immortal society? moot point it would never be available to enough of the population for it to need this type of legislation. Would immortality create a permanent ruling class? most likely an indirect one based on oligarchy in democratic country and an actual one in dictatorship an monarchy. Could the human mind even handle living for centuries? since we are talking about a case where your brain regenerate permanently (a requierement for extended life/immortality) at worst you should forget things very far in the past that you didn't thought about for a long time, just like you already do now.2
u/leigen_zeroLike you said it will be a luxury product available to only the ultra-rich. Rest of us will grow wrinkly and frail like we have done since ape first picked up a rock and smashed another ape in the head with it. The immortals will stand to make so much profit from the mortals that they'd never allow a deathless society.1
u/Low-Speaker-6670Love death and Robots episode "pop squad" Your fictional scenario played out.1
u/owjfaigs222Well seeing how the birth rates are going down in developed countries, perhaps people would stop reproducing on their own. But otherwise, if it's available to an average Joe, probably yes. Population control was already used in some countries like China.1
u/DragonWhsipererIf you want a glimpse on how that would work, you can check out the Warhammer 40k universe. It's a satirical hyper enhanced, highly advanced but very dark future of humanity, where all the darker sides of people and their motivations are magnified to the extreme. Class warfare exists where anyone who is part of a ruling class is always part of a dynasty that can get Rejuvenation treatments and live for centuries. The rest of humanity lives in terrible conditions, is allowed to propagate without restraints and any excess of the population is  used as cannon fodder for endless wars in service to those in power. So yeah, elites will hoard this undeath technology for themselves, while reaping the rewards of the rest of use for perpetuity.1
u/Leather_Office6166In a world with dense populations and no vaccines, protection against aging would be unimportant because almost everyone dies before getting old.1
u/dust_of_the_starsDon't worry. The system needs cheap slaves to perform the labor. As long as human workers are cheaper than robots, your right to produce new slaves will be encouraged. Robots that can do manual labor like cleaning and cooking are expensive and difficult to make, so there is still a long way until they become cheaper and more efficient than humans. Capitalism does not encourage space colonization or the development of innovative drugs anyway because the research required for that is risky and does not bring quick profit. I doubt there will be any meaningful progress made until 2050. So, the system will remain the same, and the population will continue growing exponentially until this planet is depleted of all the resources and pollution from wars, chemicals, plastic and factories reaches the levels not compatible with life. However, your reproduction rights are safe. Capitalism needs your children for labor.1
u/TrophallaxisCurrently, a fertility rate of around 2.2 is necessary to sustain a population. That's basically because everyone dies at some point - that's the 2 part, and some people die without having any kids - that's the .2 part. If no one died from old age, we would still need at least a 0.2 Fertility Rate just to compensate for random fatalities. Fertility rates are in free fall all across the globe. South Korea already has a fertility rate of 0.68. A lot of developed countries skirt around 1.2. And, mind you, all this with governments bending over backwards trying to incentivize big families, and people still facing a lot of pressure from their relatives and their biology. Like, I did a little poll among friends, obv. not representative, but I asked why did they have children at a certain age and not later or sooner. Every answer came down to some version of this: - not sooner because money - not later because then less chance for grandparents to be alive - not later because of biological limitations If we solve aging, all three factors change. You can keep building your life until you can have kids on your terms, spend as much time with them as you want, no compromise. Important family will still be around and your biology (perhaps with assist, but still) will still enable children. I am very much convinced that radical longevity will keep pushing down birth rates further.1
u/pjkm123987It won't be available or told to the public. Only private will ever know about it
u/StarChild413[deleted]
u/JUST_A_LITTLE_PUSHNaw. We'll send all the ageless Zombies to Mars instead. First we have to survive World War 3 before living World War Z.
u/wwarnoutif curing aging actually becomes possible, would it improve humanity, or create a dystopian future? I read a novel about an intelligent alien species that had conquered aging - and their society stagnated. Their people no longer had the pressure to "get x done before they die", and instead took the attitude, "I'll get around to it eventually...", and "eventually" never came.
u/texan-janakayIF all causes of death other than accidents were implemented (i.e. aging, cancer, etc.) we would definitely need to implement some sort of reproduction control. Hopefully people would at least put off spawning until they were older and more settled and could better afford it, instead of the welfare children we have now. In the world of sci-fi, they often solve this dilemma by making birth control implants (both sexes) mandatory at puberty. Then only when the person can prove financial security AND emotional maturity can the implant be removed. That has always seemed reasonable to me. Can't afford the baby? nope, can't have one (yet). Can't nurture it and take care of it? nope can't have one (yet).
u/Punpun86If it happens it will be a available only for the ultra rich. The rest of us useless eaters are not needed to be alive and "leech" the pension scam fund.-1
u/2mxm2If this can be solved, it will be available to the rich, not the poor. There will certainly be no interest in everyone being immortal and the number of people going to unbearable numbers.-2
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171r/floxiesLevofloxacin 500mg: Pain in finger joints and on the ligament behind knee after ...suffer_hero50%549.7PRP knee treatment2026-03-22↗
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u/DrHungrytheChemist[removed]1
u/Niceshoesbr0Sounds like you are at the right place, here is all the info you need at the beginning https://www.reddit.com/r/floxies/comments/g8cs97/new_start_here_old_please_help_here/ Probably all the pain you didn't have prior to starting levo comes from these antibiotics. One of most important info i can tell you for now is that, if you are taking any pain meds like nsaids, those are likely making things worse for you now.1
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172r/AdultCHDPeptides, stem cells and heart diseaseK00paa2430%949.4induced pluripotent stem cells2026-03-05↗
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u/calicaliWhere are you reading these things? It's not FDA approved and never been through proper human trials. The only "results" I can find are sketchy supplement ecomm storefronts, Medspas and unqualified influencers who are also selling the peptides direct from China. Did you discuss this with your doctor? This sounds like an absolutely terrible idea that will cause you harm. You hone in on your heart health by regular exercise, eating healthy balanced meals, improving your sleep quality, managing your stress, etc. You do not improve your health by taking snake oil. Please talk to a qualified physician who is aware of your heart condition. ?negative5
u/jakemalonyBPC-157 shows promising cardioprotective effects in rodent models, particularly for doxorubicin-induced damage and post-MI recovery, but human cardiac data remains limited. For your sternal healing specifically, it has more established anecdotal support in orthopedic and surgical recovery contexts. Given your recent second open-heart surgery at 34, I'd prioritize discussing BPC-157 with your cardiothoracic team rather than self-administering post-surgical tissue in the sternum is mechanically and vascularly complex, and healing timelines vary widely even without intervention. Stem cells for cardiac regeneration are still largely investigational; most legitimate programs are clinical trials with strict inclusion criteria, not cash-pay clinics. Your energy might be better directed toward cardiac rehab completion, inflammation management, and patience with sternal union, which can take 3-6+ months. If you do explore BPC-157, oral or localized subQ near the sternum would be the logical application, not systemic use for cardiac remodeling.neutral2
u/Pirate_Of_HeartsSternal pain after surgery is normal. Jumping to experimental treatments is a bit of a leap. Have you spoken to your physician about pain management and typical recovery time? Also, you're probably still in cardiac rehab, correct? If not or your doctor didn't sign you up for it, ask about it. It's PT specifically for after open heart surgery. ?neutral2
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173r/MedSpaIs PRP effective after CoolPeel laser treatment?Obvious_Relative587720%1449.1PRP knee treatment2026-03-13↗
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u/Wonderful-Bass6651It does not penetrate 10 microns, it is more like 100. Nevertheless, the laser is powerful enough to reach the papillary dermis which is as deep as you can go and still be in skin. With that said, yes. You can use PRP after the treatment.1
u/sheesh_aestheticsCoolPeel is very superficial. PRP applied afterward mainly helps with healing and skin quality, but it doesn’t penetrate deeply enough to drive strong collagen remodeling. If your goal is deeper collagen stimulation and better PRP delivery, RF microneedling combined with PRP or PRF is usually a stronger option. The needles create deeper channels and the RF energy stimulates additional collagen, so the growth factors can work more effectively.1
u/gripNripskiYou can definitely use PRP on top of a CoolPeel. At 3W it’s going around 40 microns into the tissue. At 5W it’s going around 65 microns into the tissue. It’s most likely getting to (or close to) the DEJ and the evaporated columns of tissue will soak up the PRP like a sponge. Just make sure it’s a real CoolPeel system. Lots of places advertise that treatment when they are using a lower powered device, and that will mess your face up.1
u/Lazy-Substance-5062i love coolpeel! i did 2 sessions on my chest to remove old acne hyperpigmentations and it was effectve. tho, i think it needs to be maintained every 18-24 months as they're showing again (due to sun exposure). also re PRP/PRF, i didnt do those. but i used the spa's recommended aftercare product which is a light gel comprised of retinol and copper peptide. for reference , i also did fraxel (Clear and Brilliant) but i feel that coolpeel has better results, tho longer downtime for me about 6 days.1
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174r/HelldiversSome specializations and QoL upgrades I think could be fun. With 5 points, what ...Sebanimation60%348.9regenerative medicine2026-03-29↗
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u/MoschopsMeatballA Payday 2 akin skill system could be pretty neat if implemented right, Crew chief was a pretty cool perkdeck in Payday 2, Would be nice to see a sort of leader perk here too for people who want to support others passively2
u/Paul6965I am so glad we do not have a skill tree. As cool as it sounds... it just limits playstyle1
u/TNTBarracudaIf we're already limited in skill points, why also make options mutually exclusive? I'd think selecting two similar options would be more interesting, no?1
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175r/AvascularNecrosisAVN of talusManyArm242620%1248.6induced pluripotent stem cells2026-03-18↗
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u/Mysterious-Belt-2992Yes! Me! I was 18 when I got my kidney transplant and all that prednisone gave me AVN in both Talus. I got leg braces made I started college and guys were carrying me to class 😂 BUT! They repaired themselves and got their vascular activity back! That was 25 years ago! And while is still have AVN in my left hip, with collapsed femoral head, it’s not too bad! I have put off getting it replaced. I can wear heels 👠 for a couple hours lol. Funny that’s how we gage our bone disease as women 😅positive2
u/coldjesusbeerSimilar experience. Got diagnosed with AVN of the tibia, talus, and heel. Went non-weight-bearing in a boot for the better part of 6 months per doctor's orders. The pain went from challenging to excruciating after the boot. Doctors told me there was nothing they could do for me. Stopped the boot entirely. Started getting back on my bike and becoming physically active again. Moved to NYC where I walk everywhere. Daily pain is gone 3 years later. I wear heels again. Gotta be careful walking down hills or carrying my bike downstairs, but other than that, I have my life back.negative2
u/showmenemeldaI knew time travel was real! Tell me, is 2038 better?! ?positive1
u/Mysterious-Belt-2992I know you mean 2017, right? ?neutral1
u/mangoawaynowwait can i DM you? I wanted to ask some questions because both of my ankles are cooked 🥲 and not hella people have it in the talus bone ?negative1
u/radicalelkFellow talus AVN gal 👋🏼 mine is from an injury though. I got my debridement in September, they did a Brostrom repair for instability at the same time. I do NOT regret the debridement - that deep shocking pain is near gone! However I do regret the brostrom repair. My ankle is still significantly swollen, and 2 miles is my limit for walks still (though I can lift!). Hoping for some relief there in the coming months. Surgeon suggested a full year is needed for bounce back. Anyways, thank you for sharing your story. My original doctor also gave me my diagnosis very grimly. It has been such an odd experience.positive1
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176r/stemcellsHopstem BioPlusSheepherder727340%448.0induced pluripotent stem cells2026-03-06↗
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u/Primary-Ruin8830I’ve been keeping a close watch on AKUUGO. Crossed fingers that it quickly becomes available to the public.positive2
u/Primary-Ruin8830I am wondering if this will also be a good treatment for a traumatic brain injury. It presents very similar to a stroke.neutral1
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177r/ReverseRhinoplastyThe demand for regenerative medicine in restoring the nose or ear anatomyhanginaroundthistown40%448.0regenerative medicine2026-03-19↗
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u/Massive_Classic8352You’re doing great work for spreading information about these issues1
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178r/MeniscusInjuriesHorizontal meniscus tear (red zone). Huge progress with PT. Is it possible to av...rexgenial40%448.0PRP knee treatment2026-03-08↗
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u/Party_Goose1239Hi! I’ve got a similar tear although my patellar tracks inward. I’ve been a lot of progress with PT but still think I might need surgery, meeting with the 2nd surgeon, a sports specific guy, this week. I think a big factor is what type of activity are you trying to return to? I’m a long distance runner who l loves trails, so I need a lot of trust in my meniscus.2
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179r/KoreaSeoulBeautyHas anyone tried stem cell skin treatments in Seoul?Lonely-Jackfruit-54620%1048.0stem cell therapy2026-03-09↗
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u/External_Cost1541I did the stem cell recently, there are like many different types of stem cells that you have to choose one of them as it all has a different purposes u know, for 7 days couldnt drink, smoking, or do saunas but yeah I think it was worth it oh and one important thing that I heard with the stem cell thing it is a recent treatments so you have to go to the clinics where it is gov certified1
u/Icy_Working_3732I actually tried a regenerative skin booster when I was in Seoul last year. From what the dermatologist explained, a lot of what clinics call “stem cell” treatments are more like growth factor or regenerative boosters rather than literal stem cells. It helped my skin look smoother and more hydrated after a few weeks, but it wasn’t like an instant dramatic change. The improvement was more in texture and glow.1
u/Apprehensive-Car3588I did a stem cell/rejuvenation at Wooa dermatology and you probably already know it was more of an anti aging treatment using your own blood and then they followed it with Vitaran/PDRN injections and finished with LDM treatment as part of the package. I wouldn’t say it gave me some crazy overnight transformation but my skin did look a bit healthier and more refreshed afterward1
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180r/EB2_NIWEB2 NIW Profile Review – Low citationssteampunkorange20%1048.0regenerative medicine2026-03-05↗
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u/Excellent_Elk_964I think your chance is really high, I’ve seen people who has little to zero citations were approved. Chen would find a way to make your work credible nationally. Is your work under Critical industry list?2
u/specific_account_It was approved with five citations in March 2025, PP, no RFEs.2
u/spiritofniterIf Chen offers approval or refund, then go use them.1
u/ratchetsistersSee my post1
u/Agreeable-Math-6560You have a solid profile. I don't think you will get RFEs. I hope you were more careful when you wrote your PE, explaining the national importance and benefits rather than limited to your center or lab. Best wishes!1
u/DesertFox0991Good profile to proceed... Best.1
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181r/immortalistsAgeing and the Chimera Sapien_Rumpelstilzchen_110%47.9induced pluripotent stem cells2026-03-11↗
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182r/longevityRead Me: Intro, Resources, and Materialslunchboxultimate01280%47.8subreddit:longevity2026-01-01↗
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183r/diabetes_t1NewcelX and Eledon partner up for a new stem-cell + immune modulation therapyDavidAGMM100%147.5stem cell therapy2026-03-15↗
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u/_ducttape_I don't know why this news is not getting more press - maybe it is just early? The news right now is around the islet act passing - but if this would be islet cadaver transplants, which are not the path forward for large scale. Or maybe that is for the next 5-8 years and in 8-15 years it goes with these type of cells? <insert joke about 5 years here>1
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184r/FunctionalMedicineDr Robert Abraham Orlando: background in regenerative medicineSophistry730%547.5regenerative medicine2026-03-17↗
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u/OppositeSuccessful58This is actually super helpful . It’s always a bit of a red flag when search results are scattered, but seeing it framed as a career shift from direct care to consulting makes a lot more sense. Thanks for sharing1
u/Unable_Thanks_8614I haven’t worked with him directly, but that whole “healthcare strategy over just running a clinic” mindset actually makes a lot of sense, especially in a place like Florida. It’s definitely not the easy route since there’s a ton happening behind the scenes, but from what I’ve seen, that’s usually what leads to something more stable long term1
u/iliveformyshipsFrom what I’ve seen, he really puts a lot of focus on the operational side of patient care, not just the biologics part. It felt more about setting things up so the clinic could actually run smoothly on its own. During the early stages, he was pretty accessible if something came up, and even though he gave space to figure things out, he’d step in and help when things slowed down. That balance between strategy and real support is honestly not that common.1
u/Living-Protection250This is a solid summary. From what I’ve seen, profiles like this tend to look “scattered” because they sit at the intersection of clinical care and program-building rather than a single traditional role. The shift you pointed out from direct patient care into helping clinics implement regenerative or biologics-based services is actually pretty common, especially in pain and MSK spaces where clinics are trying to expand beyond standard rehab models. That usually involves a mix of operations, protocol development, and figuring out how to integrate newer modalities into existing workflows. One thing I’d be curious about, and maybe others here have insight on, is how much of that work is focused on clinical outcomes vs. helping clinics structure and deliver those programs sustainably. That tends to be where a lot of variability comes in. Appreciate you putting this together though, it’s helpful to see it laid out this clearly.1
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185r/WorkersCompDoctors are a joke amd trying to leave me impared.Viking_Warrior10%2147.4PRP knee treatment2026-04-02↗
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u/fontimusSo you denied treatment due to a needle phobia? C'mon. You're 27. Get with the program. I've experienced post-dural headache after my third epidural injection when I was 18, a life-altering experience of pain and misery that words can't describe. Genuinely traumatic. I'm 37 now. Two days ago I got my fourth epidural, a bilateral injection (so technically two epidural in one sitting). I was scared. I told my Ortho I was scared, and why. He understood, gave me some anti-anxiety meds to dissolve in my mouth when I got to his office the day of the injection. Still scared, I trusted the doctor to do what he needed to do so I could be treated. I shut up, laid down, and ignored the world around me while he injected me. You are causing your own misery and difficulties. Go to therapy if you need to, but stop denying treatment based on fear and hypochondria.9
u/KmellowwTypical bone spurs are not work related. They happen over time. It could be a fall aggravated it but I don’t see it being likely that it caused it.5
u/Head_of_LettuceSounds like you rejected the treatment offered to you? I get being scared of needles, everyone is. But that’s life, you half to do the uncomfortable things if you want to heal.2
u/Bradley4u2nvYou cannot have the word Viking or warrior as your name and cannot handle needles. Hope you get some relief though. Hire and attorney to push for the treatments you need maybe they'll need to be done under anesthesia.2
u/Specialist_Okra4080Any specialist or second opinions1
u/Traymond26Cmon …. Blue collar and scared of needles ??? Bro do what you gotta do to get better. Best of luck 🍀1
u/BirthdayExpensive451Why are doctors a joke??? Seems like a harsh statement. If you don’t do well with needles you certainly wont do well with surgery. Ever had surgery? I would guess the surgeons don’t want to touch you because it sounds like whatever they do you will rant and have more problems. Bodies do heal—-except yours.1
u/Even_Tension_204Usually you'll have to do some other options (PT, PRP, walking boot, etc.) before you can get surgery. As someone who's had both feet done, I'd make an effort to do the other options first as surgery is not guaranteed to make it better. Problem is, you have to wait a few months after PRP to see if it worked or not. Surgical recovery takes a few months to a year for full recovery depending on how it goes. You may be walking after a few weeks, but likely would still be in pain and sore. Start thinking about other careers in case you don't get back to 100%.1
u/Zealousideal_Bet336If it is a bone spur then they will say it’s not work related get an attorney
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186r/AgingDoes stem cell therapy increase you lifespan?SpecialK23520%847.3stem cell therapy2026-03-21↗
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u/thelostdutchman68Local therapeutic stem cell injection does not have an effect on lifespan. Injected stem cells are not integrating into you systemic stem cell pool or depleting it. They act locally and transiently.3
u/peglyhubbaWow that is great to know. I’ve had my own stem cells put into my knees. And my own protein rich platelets also injected intro my non existent cartilage. My knees are so happy. They will live on without me! Haha 😂2
u/pandit_the_banditI have had almost $100,000 of treatment from Regenexx in Cayman Islands and there is ZERO chance it will extend my life. It’s solely to treat orthopedic problems2
u/WanderirGenetics is first when it comes to longevity, them environment and lifestyle they follow by a wide margin. I’ve not seen or heard of any evidence for stem cells. Do a search for studies.2
u/raj_uvGenetics and lifestyle balance is key. Stem cells only increases chances of positive outcomes as everything is subjective to the individual case at hand. I get stem cell IVs and enough exosomes for anti aging twice a year in Switzerland but I’m overall healthy and no underlying issues or injuries. In your friends case if she is getting localized injections that’s not enough for longevity imo maybe good enough from injury to recovery and some added benefits but if she’s getting IVs with enough stem cells and exosomes or growth factors then she has increased odds but no guarantees2
u/iNap2MuchCan't speak for stem cell therapy, BUT... stem cell TRANSPLANT can save your life. If you need one.2
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187r/pluribustvpsychopaths guide to defeating the hiveFrost-Flower0%2047.3induced pluripotent stem cells2026-03-11↗
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u/TheAzureMageIt is unlikely the immunity is hereditary. There are already children of immune who are part of the hive. There's no need for some elaborate effort to test this when it's already known from the first meeting of the immune. The immune are all unrelated to one another. It's definitely something else.neutral11
u/Glowing_Trash_PandaThis just seems like some overly elaborate way to try to excuse a pregnancy fetish….negative11
u/AC20212020Oh, good, another 'Carol is stupid,' post. After the initial shock of humanity getting converted I would sit down with the hive to properly discuss the specifics of how the hive works but unlike Carol I would be more thorough; asking questions like: "what happens if two humans give contradictory requests" or "what is the degree of risk the hive is willing to take when it comes to harming life" What is the point of those? They'd say it depends. Next I would request one pregnant hiver and impregnate one myself to keep in containment at my base, I would conduct research into curing the hive-infected for the next 9 months. In the meantime I would try to induce two of the 13 immune individuals to start a family among themselves or with me. From there 5 possibilities exist: .... Wtf 2.The hive comes too close to finding a way to infect us before 9 months. In this case I request 200 women within the fertility window to be placed in my prison. Afterward I arrange a meeting with the other 13 humans under the guise of a celebration for a holiday and knock them out using poison or gas during it (this is a very risk endeavour that needs be planned carefully and I may have to personally kill some of the remaning humans). Once the 200 hivers and 13 humans are imprisoned I place the hivers in a medical coma within the prison and scream at one of them until they are knocked out and I keep screaming at them for 3 days straight until all the ones except I kept are dead from dehydration. From there the plan will follow the next possibility. So it's a fully creepy fetish slave breeder post. Ok then. Also, the idea that explaining basic genetics will allow you to do genetic research and place people in medical comas and start your own breeding harem is... I give, backing out of the fetish post.negative6
u/JoeIntTheBoxThe hive foils me or there truly is no cure. In this case we are boned. There probably is a "cure" or a way to block the signal, which is what Manousos is working on. A lot of your plans hinges on months, maybe years of prep and work. Carol only has weeks before they find a way to infect her. They will get you before you can successfully get them. A quicker route that may buy everyone more time, is finding a way to block the infections first, before finding an actual cure.negative3
u/AvanchnzelI keep screaming at them for 3 days straight until all the ones except I kept are dead from dehydration 🤣 In order to save my throat I'd probably first try to blast them with a recording of terrifying screams 24/7. But if it's only face-to-face screaming that riggers their emotional seizures, then I'm not quite sure you could do that alone. Depending on how long the seizures last, you'd probably have to scream at them every few minutes. How would you do that for 3 days straight? You'd have to train yourself to do a polyphasic sleep schedule. But even with that you'd have to have at least 20 minutes of sleep, any shorter doesn't really work reliably and you'll probably miss wake-ups or have narcoleptic episodes. Since you need to scream every few minutes, this just wouldn't work. Are there alternative ways you think you could kill everyone of the hive (except for your prisoners)?negative3
u/BoingBoingBootyWhy not just ask where the best bunker in the world is. One that they couldnt get to. Take me there. Build a prison cell for me. Ok were going to do segs put these chains on. Wait while i lock down the bunker. Scream at them for hours. Wipe the bastards out. If carol and manus worked in shifts they could go untill most die of thirst. Demanding terms on day two or three would probably trigger there survival protocols. Maybe you could get some power sharing agreement where they teach you to unplurb some so all plurbs dont die.negative2
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188r/premedWould high research hours make up for low undergrad GPA?ExcitingInflation61210%1947.1regenerative medicine2026-03-12↗
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u/Agitated_Depth_6881high mcat would high research? ehhhh, do u have pubs?21
u/cardiacpandano you should focus on your mcat8
u/ApathyisDeath_Usually, if one factor of your app is low you have to compensate by increasing other factors. However, other parts in your app are weighted more (they vary from school to school). But an all around rule is GPA and MCAT are the most important. I believe as long as you have a >3.2 gpa with an upward trend of 1 year or more then crushing the MCAT will definitely help (also assuming your LORs and EC are decent to good)4
u/KaiserWCNo. Having a very high MCAT will help somewhat. But once you get sub 3.4 your chances are iffy overall without grade repair. (This is for US MD. 3.3 with a good MCAT and research is good for DO)4
u/LopsidedCan4803My cGPA was sub 3.4, and my MCAT was around average for MD matriculants. I had a ton of clinical hours but, more importantly, an upward trend in my cGPA and some time between that bad stretch of grades and now.2
u/pre-healthAre you applying MD or MDPHD2
u/TLtomorrowNo, at least, not for MD. Schools really need to see you can handle med school, especially with Step1 pass rates sitting at around 90% in recent years. Unless there's a clear upward trend, you'll need a strong MCAT score (roughly 515+) to make up for it. Probably less so if you apply DO, but I'd still heavily prioritize the MCAT.2
u/BeneficialEscape3655No, focus on MCAT1
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189r/backpainExploring stem cell research for back painQuick_Rutabaga_935630%446.8stem cell therapy2026-03-14↗
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u/Waste_Opening_9920It’s definitely an interesting area of research. Mesenchymal stem cells from sources like Wharton’s Jelly are getting a lot of attention in regenerative medicine especially for things like joint and back issues. I think sharing educational info helps people understand the science better before making any decisions. For anyone curious about the topic, looking into resources from projects like Stem Cell Club can be a good starting point to learn more about the research and how these therapies are being explored.1
u/ReplacementLevel8619You're better adressing It with whats avaliable already, stem celss themselves wouldnt work without adressing aspects of spine and Disc degeneration1
u/AutoModeratorPlease check out the r/backpain wiki for some first steps for new low back pain & FAQs [ https://www.reddit.com/r/backpain/wiki/index/ ] PLEASE NOTE: When Asking for help it is up to you to recognize when to seek medical attention. Anyone giving advice in this group is doing so from anecdotes and holds no liability. Seek advice here at your own risk. Remember to be kind & respectful. There is always a way We are rooting for your success Posts and replies that do NOT show kindness and empathy towards others will be deleted. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.1
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190r/backpainExploring Stem Cell Approaches for Chronic Back Pain – Evidence and Clinical Per...Quick_Rutabaga_935630%446.8stem cell therapy2026-03-13↗
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u/AutoModeratorPlease check out the r/backpain wiki for some first steps for new low back pain & FAQs [ https://www.reddit.com/r/backpain/wiki/index/ ] PLEASE NOTE: When Asking for help it is up to you to recognize when to seek medical attention. Anyone giving advice in this group is doing so from anecdotes and holds no liability. Seek advice here at your own risk. Remember to be kind & respectful. There is always a way We are rooting for your success Posts and replies that do NOT show kindness and empathy towards others will be deleted. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.1
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191r/DogAdviceHelp I’m desperate to find similar case(s)Reasonable-Dark-425630%446.8regenerative medicine2026-03-13↗
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u/BulkyBug3197I see that she is on doxy. Are they empirically treating her with those for possible tickborne issues? As far as food, I would offer her anything under the sun to try and get her to eat. We would resort to canned cat food, beef flavored baby food, those little Vienna sausages, as alternatives. They also do make appetite stimulants for dogs.1
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192r/MauraMurraySubDoes anyone remember who the poster, “LowerSlowerDelaware” was? Before I even ca...Walla-bee150%4546.7regenerative medicine2026-03-07↗
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u/P_SheldonPage one: "if mr Murray was awake when Maura arrived at his motel..." Let discuss. I don't believe for a single second Fred was asleep when Maura arrived back at the Quality Inn Hadley Ma and then get this too, took her father's cell phone and called BR in the early morning of 02/08/04. BS IMO. So, Fred, just slept through it all? Sure. And Santa and the Easter Bunny are real.10
u/igraduatedI'm interested in what Beagle is saying in this post from 2011 above, I've never seen that particular post. Interesting. Like most I've certainly changed thoughts a lot. I still don't think she was at wbc at that time. Did someone kill her like they allegedly said and that story was repeated to jr? Or did they set up her abduction. I'll remind you I think she was abducted in Amherst and taken elsewhere, and the car went to Haverhill. What's up with Eastover? Very weird. But I do think Beagles thoughts on the biomedical fields especially around Springfield is very interesting. Highly2
u/Delicious-Werewolf54PM me ,when your time allows...Gotta discuss a detail2
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193r/ATHXGovernment subsidy for Healios' CDMO officially approvedimz7250%246.7regenerative medicine2026-03-27↗
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u/nova8188Read 1/2 way through this article and checkout over about production facility which has athxq name all over it.1
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194r/IBSResearchMicrobiota-derived extracellular vesicles mediate gut-brain axis dysfunction in ...jmct1680%46.5induced pluripotent stem cells2026-03-29↗
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195r/OsteoarthritisPRP for Degenerative Disc Disease and Cervical Spine Osteoarthritis?No-Papaya-982320%646.3regenerative medicine2026-03-12↗
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u/ButterscotchIll1523I used it for my knee. It was a game changer. I’d talk to your doctor and ask if you’re a good candidate. I read it’s most effective for stage 1-2, but it’s hit or miss for higher stages.2
u/No-Papaya-9823[deleted]2
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196r/gradadmissionsCincinnati Children's DSRM ProgramNew-Call-461220%646.3regenerative medicine2026-03-12↗
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u/tiredofmitosisCongrats! May I ask why you believe you are admitted? Did you get a call or something?. I am waiting for the immunology program at Cindy which shares many faculty with your program. I did an in person Interview last week and enjoyed it very much, even tho i admit that this place is less well known compared to many other schools. But i genuinely think they are strong at their stuff.1
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197r/biotechWhat are the prospects for an Individual after a Bs in biomedical science/ Ms in...undercover_arn_20%646.3regenerative medicine2026-03-04↗
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u/Outrageous_Duck3227bs biomed alone is pretty mid, you either end up in low paid lab tech work or pivot out after stressing for months. ms in something niche can help but only if you’re ready to chase phd, networking, maybe relocate. industry roles are limited and hiring is crap lately, job market sucks4
u/JayceAurYou should try to get some wetlab experience as well as you get your BS. This will help you land a job afterwards. MS is marginally useful, for now. Prospects are okay, market is rough, but hiring is still there. Don't bother trying to learn about the lay of the land from online forums. Mostly it's opposite extremes going off. Talk to mentors who can provide legitamite guidance. As I've always said, do something you're talented in. That way, there is always some corner you can shove yourself into in the field.2
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198r/tresslessWhy did Pelage present only phase 2a results?Acceptable_Phase62410%1446.1regenerative medicine2026-03-28↗
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u/otherwiseofficialThey will and weren't lying. Their CMO even already said they wouldn't present the phase II results on this conference, but this is tressless so everyone gets crazy excited over nothing.18
u/nanananana45someone else posted in another thread that there is no phase 2b and they went straight to phase 3 EDIT: The link you provided is a post to an announcement about series b financing, and it mentions Phase 2a and phase 3 trials, but there's no mention of phase 2b. I could not find anything via a google search where Pelage has ever said there was 2b study in process or planned, and it was only speculated by this site and other hair loss posters theyd be in phase 2b late last year11
u/trey_19833So I’m not really concerned at all by this, it’s pretty standard stuff for drug development. My problem is how everybody on Reddit is over hyping this treatment, and I’ve been around long enough to remember when they did this for CB-03-01 too. Some people were even saying it would be better than dutasteride. The most likely outcome is that pp405 works as a hair growth stimulant, and probably slows balding. It’s cool because it’s a novel mechanism and what makes this a good treatment is that it gives people alternatives. That being said, I doubt it will work long term as a monotherapy but will be great to add to a stack. For example, I tried 5AR inhibitors but I can’t tolerate them, so instead I run a stack of nizoral, pyrilutamide, minoxidil and alfatrodial and this has given me great maintenance. The more new drugs we have, the more choices we have to mix and match stacks to tailor it to what’s tolerable for us as individuals which is a very good thing. That’s good news, and the more tools we have, the more options we have to fight hairloss and we aren’t stuck with having to to either take finasteride/dutasteride or go bald. That being said, pp405 will probably be good as a stack with other drugs, hell it may even work great with minoxidil because you have two hair growth stimulants with different mechanisms of action, but we will still need to target androgens. If you can’t do that with a 5AR we now have pyrilutamide, CB-03-01, RU58841, and hopefully GT20029 in the future. None of these will cure baldness, and none of these will work for everybody and all of these need to be started before you’re bald but every few years we get more options to choose from making treatment more widely available for different peoples personal body chemistry. I don’t think pp405 is a flop, I think it will be a great addition in the future but I don’t think we’ll replace the need to inhibit androgens in the scalp ever because it’s an unavoidable issue.10
u/Brilliant_Run3426I agree was disappointed with today, but what they actually said was: "at a future medical meeting in 2026." Which does not specify today3
u/Specialist-Escape300because they only have 2a result1
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199r/VeteransAffairsPRP Injections for Knee OsteoarthritisBoner_Sun0%1345.9PRP knee treatment2026-03-26↗
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u/FragrantJump6663In general as far as I know from working on the civilian side of health care… PRP injections are not covered by insurance or Medicare. Worked at the VA now 16 years and no patients that I have ever worked with in physical therapy has had them. Now that isn’t a guarantee that no one in the VA does them. I always say… every VA is slightly different from each other. Different vendors, different items they supply or don’t supply. Edit: if your knee is absolutely destroyed it sounds like you are headed towards a knee replacement. They don’t do stem cell replacement either at my VA4
u/beekeeper727You can get them but it is quite the journey in order to get approved. Each VAMC has different protocols on who gets approved and how many approvals they can give. I tried to get them for my lower back and it took almost a year of trying and advocating and they still denied me, but my neighbor was approval for a similar issue in about 6 months! Keep advocating, hoping you get what you need.3
u/nurse-12345678I’m sorry you’re dealing with this, sounds incredibly frustrating, especially when you’re trying to stay functional day to day. A couple things to clarify that might help you advocate for yourself: • An MRI isn’t what’s used to diagnose osteoarthritis, X-rays show OA. MRI can show soft tissue detail, but it usually doesn’t change management in advanced OA cases. • If your OA is truly severe (“bone-on-bone” with significant functional limitation), relying on repeated injections, whether PRP, gel, or cortisone, is generally not considered a long-term solution. Even PRP, while helpful for some, isn’t strongly supported in advanced OA. • You’re absolutely right to be cautious with frequent cortisone injections. There is evidence they can accelerate cartilage breakdown over time, especially if done repeatedly. • If your knee is as bad as you describe, it may be time to have a serious discussion about total knee replacement (TKR). That’s typically the definitive treatment for end-stage OA and often gives much better, longer-lasting relief than injections. PRP is one of those treatments that sits in a gray zone, some patients swear by it, but the clinical evidence is not strong, especially with advanced osteoarthritis.3
u/DBasUrMomOr the “person” your wife spoke to lied…who randomly discusses their spouses medical issues with a stranger?3
u/DriftingtheDriftlessYou have all the right answers already. Not all VA’s do it, maybe the other guy lied, or maybe they did do it at one point but the provider that did it left, etc… As far as your question about Community Care though, the answer is No. Because PRP is not FDA approved to treat the condition it can not be authorized by CC. I have heard of it accidentally being covered in CC as the TPA erroneously has paid it, but the rule is CC can’t cover it if it’s experimental.2
u/FoxPast175Not every VAMC will do it. Or has the ability to offer it. Mine would love to start offering them but it literally takes an act from Congress to make it happen.2
u/Fine_Researcher_15I’ve received prp in my shoulder at a va hospital. This was within the last year.2
u/Thehaas10Just go get a knee replacement. I am 39. I got my hip replacement 1 year ago. Best decision I ever made. I was service connected for it previously so that does help. I live in Charlotte. Idk if community care could get you into a Neogenix style place but ultimately stem cells are going to be much longer lasting than any PRP injection is going to be. If you have deteriorating OA in your knee you should go see an orthopedic PT and go from there. I am an orthopedic PT and I see twenty plus cases of knee OA every week. While I can't help all of them, I can make a difference in a lot of them. Also while an MRI is beneficial a plain X-ray is all you need to determine extent of OA. Unless you have some meniscal issue as well. If you have a meniscus tear PRP could help but also depends soley on the type of tear you have and the location of that tear. Blood flow in the menisci are not great and that's why most of them get debrided vs repaired.2
u/Dependent_Squash1602VISN8 nfl offers it1
u/Admirable-Mud-3477Stem cell therapy for arthritis in Mexico. The VA does a disservice to veterans loading them up with pills when there are extremely effective treatments that actually help you live a life free of pain. But we gotta travel outside of the U.S., spend countless hours doing research to find to best doctors and the best treatments abroad, and pay out of pocket, which compared to the US, everything is so much lower in costs. If not Mexico due to the current conflict, I highly recommend you do research on stem cell therapy in another country (Columbia, etc). Living in pain is just asking the VA for more medicine that doesn’t help you in the long run. Sadly.
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200r/ATHXHardy to present at the Congress of the Japanese Society for Regenerative Medici...imz7230%345.8regenerative medicine2026-03-04↗
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u/imz72[From the registries (machine-translated from Japanese)]: Multipotent adult progenitor cells for use in treating intracerebral hemorrhage - Patent Application 20070122999 Abstract [Problem] Multipotent adult progenitor cells for use in treating intracerebral hemorrhage are provided. [Solution] Aspects of the invention described herein relate to the administration of multipotent adult progenitor cells to treat intracerebral hemorrhage. Previously, stem cells have not been considered useful for treating ICH. As described herein, it has surprisingly been found that administering multipotent adult stem cells as described herein to treat ICH has an unexpected and surprisingly effective therapeutic benefit on ICH outcome, as shown by measures of hematoma volume, cerebral blood flow/perfusion outcome, and functional neurological assessment. ... Inventor: Robert Mays Current Assignee: Healios KK https://patents.google.com/patent/JP2025181956A/ja [Issuing Country] Japan Patent Office (JP) [Publication type] Patent publication [Registration date] 2026-02-20 [Issue Date] 2026-03-03 [Title of Invention] Multipotent adult progenitor cells for use in treating intracerebral hemorrhage International Patent Classification] ... [Number of claims] 52 Application date】2020-01-30 [Publication Date] 2022-04-25 [International Release Date] 2020-08-06 [Date of request for review] 2023-01-26 [Priority date] 2019-02-01 [Priority claiming country/region or organization] US [Name or Company Name] Healios Co., Ltd. ... [Claims] [Claim 1] A composition for treating intracerebral hemorrhage and reducing intracerebral hematoma volume in a subject, the composition comprising multipotent adult progenitor cells that express oct-4, rex-1, and rox-1, the multipotent adult progenitor cells being neither embryonic stem cells, nor embryonic germ cells, and capable of differentiating into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages, and being allogeneic or xenogeneic to the subject. ... https://ipforce.jp/patent-jp-P_B1-07822785 My [imz72] note: 1.I don't know what this procedure means. 2.In March 2021 Athersys published this abstract: Multipotent Adult Progenitor Cells as a Highly Promising Therapy for Treatment of Intracerebral Hemorrhage 3.In November 2021, Dr. Robert Mays, who was then Head of Neuroscience at Athersys, said in an interview: "We have ongoing preclinical work a number of indications, we've got the most of them continued down the line, including great hemorrhagic stroke data and we hope to be submitting that paper in 2022." However, this paper has not been published since. 4.In March 2022, BJ Lehmann, who was the Interim CEO of Athersys back then, said at a Maxim presentation: "Ischemic stroke, as I mentioned, is our lead indication. I think we all understand the nature of the opportunity to help patients here - significant and increasing incidence as the patient population ages. There's both ischemic stroke and hemorrhagic stroke. We've demonstrated in both varietals we can have potential effect. We've done clinical work in ischemic stroke, and just preclinical work in the hemorrhagic area, but we do believe we can impact both types of strokes in a meaningful way."3
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201r/physicianassistantCareer PivotShoppingObjective66630%345.8regenerative medicine2026-04-01↗
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u/bootyhole_licker69honestly 3 years out is still super early, you didn’t box yourself in at all. sell the procedures, comfort with needles, talking people through painful stuff, time management and running your own schedule. em and hosp both like folks who can be fast and independent. be ready to own the “i miss real medicine” narrative in interviews so it doesn’t sound like you’re just bored with aesthetics. and yeah, even as a PA it’s weirdly hard to move around now, hiring seems way messier than it should be3
u/foreverand2025I’ve always done traditional medicine but hope this is helpful: How did you market yourself coming from a non-traditional or niche field? Focus on the traditional medicine aspects you are doing. You are doing procedure. You are working with patients, writing notes, etc. • What skills would you emphasize from a procedural/aesthetic background that translate well to EM or inpatient medicine? See above. • Are there certain specialties that tend to be more open to PAs making a pivot like this early in their career? Medicine in general is so understaffed that most places are open to training you if you have a decent personality and are willing to learn. Apply broadly and to jobs that look like good gigs and interest you. • Anything you wish you had done differently when making the switch? I’ve jumped around specialties my whole life. Just wrote another reply about this but we don’t really get pigeonholed. PAs are lifelong learners and by design meant to be flexible to fill gaps where needed. Find a doctor and/or group of seasoned PAs willing to train you, read from good sources on your own, etc. My general advice to people is pick a job based on pay, schedule, work culture, etc and weigh those things more heavily than specialty itself. I’ve been doing this over a decade now and believe that the specialty (unless you really hate or love it) falls quite a bit lower on the priority list than most people think. That said and with all due respect I’d 100% walk away from any kind of aesthetic/naturalist/etc type work. I’m not here to slam anyone and to each their own but especially as a newer PA I would strongly encourage you to stay in traditional medicine and look at aesthetic or whatever type work more of a field to go into once you’re truly seasoned and to do so just for pay/hours type reasons. Just my opinion.2
u/Ok_Glass_7213No advice but would love an update on this and how it goes!1
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202r/saudimedicalخلايا جذعية بين الأمل الطبي والجدل الأخلاقي… رأيكم؟Peachy700220%545.8induced pluripotent stem cells2026-03-29↗
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u/everglow_33انا اشتغل على خلايا جذعية والموضوع تغير، في عالم اسمه ياماناكا اكتشف طريقة كيف نرجع خلايا بالغة لوضعها القديم وفاز بنوبل ٢٠١٢ وهي الطريقة الحديثة الي نستخدمها الحين بدال ما نستخدم من اجنة او من شخص ثاني نستخدم من الشخص نفسه. ما اعرف اذا تطبق بالمستشفيات او لسا لكن شغالين عليها في المعاملpositive2
u/heba759الصدق عن نفسي اي اذا ما انزرعت فيه الروحneutral1
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203r/kidneydiseasemesenchymal stem cell infusion therapyFan_Fav10%1245.6stem cell therapy2026-03-11↗
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u/Select_Safe548Sounds new or experimental. What country are you in?2
u/TheAbominableAlfieI'd be hesistant to pay that without extensive research and guarantees. Dialysis is over 50k per year. If this treatment worked it would be a lot more than 27k. It looks like they've developed a price point which some people would be willing to gamble on.2
u/Here-2-Help2622Muse stem cells for 10k at DBC1
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204r/OnenessMovementSexuality, Creation, and Expansion of Consciousness: Web of Life (Part 4A)AuroraCollectiveV20%445.0induced pluripotent stem cells2026-03-06↗
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u/rebb_hosarThis was incredible and mirrors the internal struggle I've been trying to contend with for over a decade. In truth, while having not eaten meat and while taking personal responsibility for the effect of my excesses as a human, I feel the pressure seems to compound. It's akin to a type of world empathy which feels as though one is existentially being burned alive. I find that our destructive pattern of consumption and destruction just may be who we are. What is the function of a singular, reluctant, self-aware cancer cell or virus? Can it only stop and observe in horror?positive1
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205r/MeniscusInjuriesDebating 2nd PRP injection.Capital-Just10%1045.0PRP knee treatment2026-03-19↗
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u/Bulky-Battle7926Injections don't heal anything. Get a repair surgery.1
u/RacacooonieFor me, my one and only shot kicked in about a month after I got it. I had improvements in pain and ROM that lasted me six months. In the first month of waiting for it to work I was not worse - just my baseline chronic pain and limitations. I would ask your ortho about other options or the need for a new MRI to evaluate for other causes of your symptoms. Conversely, could be time to find a new ortho! It took me five tries - five different orthos to find one that could actually identify the source of my pain and recommend the right treatment.1
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206r/KneeInjuriesPRP - shot in knee cavity and VMOFantastic_Silver_37010%1045.0PRP knee treatment2026-03-18↗
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u/suspens-I had prp done on my meniscus. Hurt like hell. Felt like my knee was going to explode. Knee was swollen for 2 weeks . Very tender after. My used to click during every step. Doesn’t anymore. Would be nice if it lasted longer2
u/RacacooonieFor me it didn’t kick in for a month. Then I had great relief and improved ROM for about six months.1
u/Live_Series1806Have you tried a muscle stimulator? I recommend the brand complex, they make a great product, sometimes can be put through insurance with a physio/chiro note for a portion of it. Its allowed me to build up strength he might VMO and get certain muscles firing that were dormant after my surgery1
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207r/OverwatchMy idea for a Mercy reworkSquidIsALesbian0%1045.0regenerative medicine2026-03-24↗
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u/katyadcAs we are all aware, Mercy is just kinda boring to play as or against and has been for some time Counter point: we are not all aware that Mercy is kind of boring to play as or against and has been for some time. Because it isn't true. If you think Mercy is kind of boring to play maybe the better way to look at it is: "Mercy is boring for ME to play" and just don't play Mercy. No one is forcing anyone to play Mercy and from what I understand she gets banned a ton in comp (which I don't play), so what's the big deal? I find Mercy extremely fun to play because she forces you to pay attention to everything going on to be able to help the team and keep yourself alive. You're constantly making quick decisions out of the blue as situations change. There are all kinds of calculations a good Mercy needs to make in their head as to how much risk to put themselves in, etc. Honestly I kind of consider her a character for control freaks because she can give you much more precise control as to how to influence the game with making decisions as to who to heal/buff/rez or not. That's pretty stimulating, but ymmv if you are just playing her as a passive healer or buffer. A good mercy should be actively engaging with the events of the game. How is that boring? And, to be honest, if you think Mercy is kind of boring to play against... who cares? It's not up to other players to play characters or in a way that makes you happy or engaged. You gotta find that in yourself. Maybe I've missed them, but why do we never see as many posts about changing Widowmaker? We see them, but it's not NEARLY as many as on Mercy or some other characters. I mean isn't she boring to play as or against? She just sits in the back and plinks people. So exciting! C'mon.8
u/Creaddd_44Resurrect would essentially be unusable past Plat if it required line of sight throughout the full cast time. The average number of resurrections that high elo players get per 10 is around 3-4, and the majority of these are ones that are only able to be pulled off due to Mercy weaving behind cover.3
u/MaLLahoFFAs we are all aware ???????? I don't think Mercy is boring to play, play against, or has a bad design. "...give one of the most well known characters in the game a proper kit." She heals, damage boosts, has a sidearm, is top 3 best mobility in the game, and has a unique and game-warping ability. What part of that isn't a proper kit?3
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208r/stemcellsAre there cardiologists that specialize regenerative medicine?SoManyQuestions520010%944.7regenerative medicine2026-03-26↗
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u/Significant-Pear-545A great friend of mine is a Neurosurgeon and he happens to be a stem cell pioneer in South Florida. He's very easy to talk to and has a way of putting things in terms that are understandable for those of us who aren't literal brain surgeons lol. I know he offers some level of telemedicine but tbh I don't know the details. Let me know if you'd like his info and I'll be more than happy to connect you with each other. Best wishes on your journey!2
u/silverfolders3online physicians for this stuff sound dope, have you found any leads yet?2
u/slicesndicesI might use the email addresses you’ve already found (in your 2nd post) to 1) inquire of the services these providers offer and perhaps 2) elaborate on what you’re exactly looking for and 3) your cardiac history, if asked. And, ask if the cardiologist knows of any neurologists specializing in regenerative medicine. This type of medicine may be more advanced internationally in Mexico, India and Germany as of this date. I suspect OP might find some researchers helpful, if they are willing to communicate, their email addresses are generally found on their published studies.2
u/Thoreau80There are both at the Mayo Clinic.1
u/Bodigaron1981I have worked closely with a team of three cardiologists who did over 500 patients of stem cells for Ischemic Heart Disease. Two of them retired already, the last one I still see often for a study we are doing together. I have met a few of these guys but there are not so many with that kind of experience1
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209r/IndicKnowledgeSystemsThe Pioneering Journey of Ramamoorthy Ramesh: Innovator in Complex Functional Ox...Positive_Hat_541450%44.5induced pluripotent stem cells2026-03-26↗
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210r/OncologyThe Role of Cytokines and Chemokines in Pre-metastatic NichesNerdfighter33350%44.5induced pluripotent stem cells2026-03-17↗
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211r/Science_IndiaJapan Approves Stem-Cell Treatment For Parkinson's In World FirstVCardBGone50%44.5stem cell therapy2026-03-06↗
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212r/ATHXSumitomo's iPSC product for Parkinson's: listing for reimbursement by June; 1st ...imz7230%244.5induced pluripotent stem cells2026-03-09↗
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u/imz72Machine-translated from Japanese: March 9, 2026 Sumitomo Pharma and Sumitomo Chemical provide financial and human resources support for the parent-child bond that supported iPS drug approval Sumitomo Pharma has received approval to manufacture and sell a regenerative medicine product using iPS cells. It took more than 10 years for the company to fully launch its iPS drug discovery business, which began in 2013. Despite facing a funding shortfall after the patent expiration of its flagship drug, the company was able to secure approval thanks to the support of the entire group from its parent company, Sumitomo Chemical. "Our focus is on small molecule drug discovery, and there were some internal doubts about whether regenerative medicine could really be achieved. With this approval, we are now confident that the entire company can work together," said Sumitomo Pharma President Toru Kimura emphatically at a press conference on March 6. "We are the first in the world to commercialize pharmaceuticals derived from iPS cells, which can differentiate into any cell type in the body. Amchepry, a neuronal cell line for Parkinson's disease, is surgically transplanted into the brain to compensate for lost neuronal function. Our goal is to provide a fundamental cure, rather than simply suppress the progression of symptoms." This approval is conditional and time-limited. The company aims to obtain further data on efficacy and safety during the seven-year approval period before submitting a formal application. The first patient could be transplanted as early as the end of 2026. Professor Yamanaka joined the company the year after winning the Nobel Prize Sumitomo Pharma established a specialized department in 2013 and entered the iPS drug discovery business. The previous year, Professor Shinya Yamanaka of Kyoto University, who developed iPS cells, had won the Nobel Prize. Sumitomo Pharma (then known as Sumitomo Dainippon Pharma) had focused on small molecule drugs for the nervous system and cancer, but saw potential for growth in this field. In 2014, the company opened the Regenerative and Cellular Medicine Kobe Center in Kobe, and in 2018, it began operating the manufacturing plant SMaRT. The COVID-19 pandemic, which began in earnest in 2020, cast a dark cloud over the development plan. Clinical trials that had begun in 2018 were delayed. Discussions with the Pharmaceuticals and Medical Devices Agency (PMDA), the review authority, then ran into difficulties over the interpretation of clinical trial data based on a small number of cases. Financial difficulties also arose. In 2023, the patent for its mainstay schizophrenia drug, Latuda, expired in the United States. As business performance deteriorated significantly, research and development expenses, which had exceeded 90 billion yen in the fiscal year ending March 2024, were halved. Nevertheless, the company continued to invest around 10 billion yen [$63 million] annually in its regenerative medicine and cellular medicine business. Sumitomo Chemical was the driving force behind this. In 2024, Sumitomo Pharma spun off its regenerative medicine and cellular medicine business and established a joint venture with Sumitomo Chemical called "Racthera." While most of the personnel responsible for development were provided by Sumitomo Pharma, Sumitomo Chemical invested approximately two-thirds of the capital. The manufacturing base was also transferred to another joint venture called "S-RACMO," creating a system in which the entire group could provide support. It was not an easy decision for Sumitomo Chemical either. In addition to the deteriorating performance of Sumitomo Pharma, the company's petrochemical business was also struggling, resulting in a final deficit of over 300 billion yen [$1.9 billion] for the fiscal year ending March 2024. There is still talk of selling Sumitomo Pharma or partnering with another company. The reason for the continued support is that it will enable the group to utilize its collective strength and is expected to be a driver of future growth. At a press conference on March 6, Sumitomo Chemical President Nobuaki Mito emphasized that he would like to develop iPS medicine as "one of the pillars of the group." "Sumitomo Chemical conducted research on regenerative cells in the early 2000s, and many of the researchers involved at that time are also active in this project. We will mobilize all of our group's resources to work towards the final goal," he said. To evaluate the safety of chemicals on the human body, the company has been working on research into using embryonic stem cells (ES cells) as an alternative. Amchepry still has a long way to go before it can become profitable. Kimura acknowledges that "there will be almost no impact on our business performance over the next few years, and in fact, research and development costs for clinical trials will increase." The Japanese market is positioned as a place to build a track record. Thpositive1
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213r/Scholar[Article] Mesenchymal Stem Cell-Derived Exosome miR-153-3 Induced M2-Type Polari...Previous_School_868430%244.5induced pluripotent stem cells2026-03-15↗
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214r/squarespaceHELP: Image Button Pop UpLow_Elevator_596520%344.1regenerative medicine2026-03-26↗
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u/Maximum_Truth_1832Squarespace doesn’t have native image hotspot hover like WordPress plugins, but you can recreate it with custom CSS positioning or embed tools like ThingLink. Just remember hover doesn’t work on mobile, so click popups are usually better. I’d probably map the interactions first in something like Runable before building it so positioning everything is easier.1
u/SeaJob544Squarespace doesn’t really have native hover popups like that, but you can get close a few ways. One option is using an image block with click-through + summary block below, then styling it to feel interactive. Another is using gallery sections with overlays, those let you show text on hover. If you need true pop-up style points, you’d probably need a little custom CSS/JS. I’ve seen people also fake it with accordion blocks tied to image sections. Are you trying to keep it mobile-friendly too? Hover effects can get tricky there.1
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215r/KneeInjuriesWhat treatment should I pursue after my knee injury?Mountain-Many476620%344.1PRP knee treatment2026-03-08↗
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u/Imaginary-Pie-7935In september I tore my MPFL. My knee buckled and I heard a pop and couldn’t walk on it, went to the emergency room and I got an X-ray but they informed me they saved MRI’s for immediate head injuries. If your local Urgent care / ER will give you an immediate MRI I would suggest going there for same day treatment. If you have any old pairs of crutches I strongly suggest walking on those for the time being. Call your ortho department today and request an evaluation as soon as possible and explain that you have a suspected ACL tear. You will be triaged as urgent and seen within the week.1
u/Sbauer1875Check to see if there are walk-in Ortho offices in your area. That would be your best bet! Urgent care can usually only do X-rays, whereas the ER has the capability to do more in depth imaging. A regular Ortho office may only see you if you have a referral from your PCP. It just depends on what resources you have in your area. Good luck to you, I hope wherever you go, they can get you feeling better! I have both of my knees replaced, so I'm very familiar with how painful they can be.1
u/Puzzleheaded_Cap2017Hearing a pop during a side impact in rugby is something doctors take seriously because that mechanism can involve ligaments like the ACL or MCL. The fact that you still have some movement and can lightly bear weight is encouraging, but it doesn’t always rule out a ligament injury. Most people in that situation start with urgent care or a primary doctor just to check for fractures and swelling, and then they usually get referred to an orthopedic specialist if a ligament injury is suspected. An MRI is what typically confirms whether it’s a partial tear, sprain, or something involving the meniscus. In the meantime, rest, ice, compression, and keeping weight light on the knee usually helps prevent further irritation until you’re evaluated. Right now does the knee feel unstable or like it might give way when you try to turn or pivot, or is it mostly soreness and swelling?1
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216r/AskTurkeyVisiting Edirne in April. I need information about TRAKYA UNIVERSITY HOSPITAL fo...ChangingSong10%743.8stem cell therapy2026-03-22↗
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u/GaelenmyrDo public hospitals even offer advanced treatments to foreigners? I thought they were for citizens and residents only. Foreigners (non-residents) usually go to private hospitals.4
u/ChangingSongOh my goodness! I truly appreciate your concern and your reply. I can tell that you only want to help me and I think you are very kind to care.1
u/danceofeternity_0Hi I am from Edirne. Actually u can contact secretary of hospital. I suggest that take appointment from directly to prof doc. I don't know if they ate doing stem cell therapy btw.1
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217r/catsLooking For Advice And Personal Experience Administering Chlorumbucil & Prednisi...These-Yam-189210%743.8regenerative medicine2026-03-28↗
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u/bonniejeanne2The first thing I noticed wrong with my Mittens was that one pupil was larger than the other. They gave her steroid shots and antibiotics in case it was an infection. That didn't help, so got X-rays. A small spot appeared near her lungs, which they said might be cancer or she might have inhaled liquid. Then she quit eating and was throwing up white mucus. Ultrasound showed kidney infection. More injections and pills to make her want to eat, and still she wasn't better. Did another X-ray about 3 weeks after the first one and the spot near her lungs had grown considerably. Took her to LSU vet clinic which specializes in oncology 3 days ago. She had a fast growing cancer that had gotten into her bones and spread through her body that fast. They said they could do rounds of chemotherapy, that would require a lot of hospitalization, but might only give her 4-6 months more to live. Plus, it would cost several thousand dollars. I wasn't going to put her through all of that. She already hadn't been eating for a week or more. Picked her up Thursday morning and brought her home. She was so happy to be home. Gave her one more loving night here, then took her in yesterday to be put to sleep. Broke my heart. She was my little shadow. I had just lost my Poppy in February to intestinal cancer. I have two babies left and am praying they don't get sick. Spent over $3000 in vet bills in the last three months trying to save them. I hope your baby recovers.1
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218r/systemictendinitisLithium and B12 Injections as a potential treatment for post-accutane induced te...Zodianz40%143.5induced pluripotent stem cells2026-03-30↗
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u/Effective-Rice-3732I'm curious of supplementing lithium ortate would helpneutral1
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219r/NovosLabsWhy the ageing immune system may help drive body-wide ageingNovosLabs40%43.5induced pluripotent stem cells2026-04-02↗
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220r/InterstellarKineticsBREAKING: A One-Time CRISPR Gene-Editing Therapy Just Eliminated Painful Sickle ...InterstellarKinetics40%143.5stem cell therapy2026-04-02↗
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u/InterstellarKineticsThe 27 out of 28 number is the one that will anchor this story in the literature. Clinical trials for severe genetic diseases rarely produce outcome data this clean. The one non-responder in the cohort will be studied as carefully as the 27 successes because understanding what made that patient’s biology different is the key to predicting which future patients will respond. The donor registry disparity angle also deserves more attention than it typically receives in CRISPR coverage: bone marrow transplant as a cure for sickle cell disease has existed for decades but has functioned, in practice, as a cure primarily available to patients with a matched sibling donor, which skews heavily toward smaller families of European ancestry. An autologous therapy that requires no donor erases that disparity by design. If reni-cel moves through regulatory review with this data supporting it, the access question shifts from biology to economics, and that is a different and more solvable problem.1
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221r/SicklecellAbout 1% of eligible sickle cell patients have received gene therapy since appro...tucksedo40%43.5stem cell therapy2026-03-19↗
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222r/KneeInjuriesAnyone done PRP injections and for what knee condition/injury specifically?Dry-Homework334440%43.5PRP knee treatment2026-03-31↗
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223r/ScienceNcoolThingsA new stem cell therapy helped grow stronger bones in people with osteoporosis, ...sibun_rath1090%42.9stem cell therapy2026-03-25↗
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224r/jovemedinamicaPortugal, a capital mundial de biohacking: apanhar sol e comer sardinhas. Não se...Green_Insurance4916140%1542.8regenerative medicine2026-03-13↗
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u/--____________-Porque é que fazem isto. Escrevem assim. Isto faz imensa confusão. Não entendo. É estranho. A malta do linkedin é assim. Escrevem. Não pensam. Porque é que escrevem assim????13
u/sad-kittenxPqp, já não bastava tudo o resto.7
u/bartolomeudebragancaEsta gente vive mesmo numa bolha. Não devem conhecer a famosa pança de vinho verde tinto3
u/luckynarWalkable cities.... pessoal, não se metam na droga.2
u/Lucky_Ad5440Dá-me vómitos essa conversa de IA Ex-pat... não há pachorra.2
u/and_guerrO The Algarve é mesmo crime contra a humanidade fds1
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225r/ATHXPhase 1/2 trial for Parkinson's using iPS cells underway in the USimz7220%242.8induced pluripotent stem cells2026-03-28↗
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u/imz72BTW, Saisei Ventures, which is a subsidiary of Healios, is one of the seed investors of Kenai Therapeutics, as is shown in the presentation: https://youtu.be/mUMLUZchAJw?t=693 and on Saisei's website: https://www.saiseiventures.com/portfolio/ Gemini says: Saisei Ventures is listed as a participating investor in Kenai Therapeutics' $82 million Series A financing round, which was announced in early 2024 (and is a primary part of the company's total funding of approximately $89 million as of 2026). This round was co-led by the Alaska Permanent Fund Corporation, Cure Ventures, and The Column Group, with Saisei Ventures and Euclidean Capital also participating. Regarding the exact percentage of ownership, this information is not publicly available. As a private biotechnology company, Kenai Therapeutics is not required to disclose the specific cap table (the breakdown of who owns how much) or the individual equity stakes held by its venture capital partners. In the venture capital industry, these details are typically kept confidential between the company and its investors. ?neutral1
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226r/stemcellsIs stem cell therapy for autism abroad even worth considering?hot55x20%242.8stem cell therapy2026-04-01↗
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u/hostofthetabernacleAre you aware of the GAPS diet for autism? We put our son on it and the changes were pretty noticeable. The nice thing is that it is cheap and risk free. The challenge is finding stuff that they are willing to eat especially after they are accustomed to the standard diet. Luckily Ai has been pretty helpful in this regard. That said I would recommend MUSE cells which are a type of stem cell that can cross the blood brain barrier. Our son has cerebral palsy and autism and the stem cells have definitely made a difference. Just beware of any clinic that claims that one treatment will be enough and make sure they are used to dealing with pediatric patients. Feel free to dm me for clinic recommendations we did a crazy amount of research before deciding on a clinic that we felt like we could trust.1
u/Ryan_MedConsultantIt totally makes sense you’re looking into this, but the hard part about the "abroad" search is separating the actual medical protocol from the clinic's marketing. The fastest way to make this less overwhelming is to pin down one missing piece. Instead of focusing on the destination or how fancy the hospital looks, it usually helps to narrow down the exact cell source and administration route (like IV vs intrathecal) first. When you were looking at those clinics, did they actually explain why they use a specific route for a 6-year-old, or was it left pretty open-ended?1
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227r/phlebotomyWhat type of phlebotomy am I doing at a stem cell therapy clinic?alyssapere20%242.8stem cell therapy2026-03-25↗
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u/Constant-Quality-692You'd be the phlebotomist at that office,  but still performing regular lab testing just like at any other lab, hospital or office. It's not donor phlebotomy, it's just at an specialty office but same as "regular" phlebotomy,  so not considered a step up exactly. Except that most people really enjoy working as a phlebotomist for a single medical office.  But congratulations! I work at a specialist office as well and absolutely love my job.1
u/Ambitious-Candy-4190You probably won’t actually be collecting the stem cells, I would think it would be like any other clinic and you’ll still just be getting routine draws or maybe some specialty tests1
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228r/ATHXSenior advisor at Boston Consulting Group questions Japan’s revised pricing rule...imz7220%242.8regenerative medicine2026-03-25↗
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u/imz72Machine-translated from Japanese: March 24, 2026 Astellas opens its Nakanoshima Cross lab to the public, showcasing automated cell culture using robots and AI On March 24, Astellas Pharma unveiled a development base opened by its joint venture with Yaskawa Electric, Cellafa Bioscience, at Nakanoshima Cross, a cutting-edge medical hub in Osaka. The base will combine the humanoid general-purpose robot "Maholo," developed by a subsidiary of Yaskawa Electric, with artificial intelligence (AI) to advance the practical application of automated cell culture technology. Cell therapy using iPS cells and other living cells means that variations in the manufacturing process directly impact quality. Traditionally, much of the process relied on the manual work of skilled technicians, making reproducibility and scaling up challenging. Maholo is said to automate more than 90% of the manufacturing process. Remote operation is also possible, contributing to labor savings on-site. At the event held on the same day, Cellafa President Hidehito Yamaguchi said, "We will introduce robots from the research stage and build a foundation that allows us to run everything from development to manufacturing in one place. We want to accelerate the industrialization of regenerative medicine." The company was established in September 2025 and will be engaged in contract work for universities and startups, developing cell manufacturing processes and manufacturing investigational drugs. The Nakanoshima Cross base will serve as a hub for incorporating cutting-edge technologies and coordinating with customers. https://www.nikkei.com/article/DGXZQOUF241070U6A320C2000000/1
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229r/Scholar[Article] Comparative effectiveness of a 3-month treatment for knee osteoarthrit...Fragrant_House131720%242.8PRP knee treatment2026-03-10↗
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u/GD4E1https://www.mediafire.com/file/at7h1f8f46b9g91/1-s2.0-S1063458425001773-main-safe.pdf/file1
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230r/ibsStem Cell Therapy for IBSusername63842910%542.7stem cell therapy2026-03-22↗
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u/goldstandardalmondsIt’s only in clinical trial stages and experimental. You’d have to join a clinical trial.1
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231r/bioinformaticsSeeking expert perspective: Is there a gap in cross-modality cell identity & dif...Which-Banana19470%542.7regenerative medicine2026-03-21↗
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u/standingdisorderYour questions are valid but cover things that are covered in recent review papers. You should look over those to find research gaps. To summarise those reviews in relation to your questions: efficiency can always be improved, not really (differentiation?), experimental iteration meaning what? Validation, sure. Scientists are not doing trial and error. You build evidence for targets and test if your evidence is supported. Literally every field. That’s science.4
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232r/BANDOFBROTHERSOFSRNEWith FDA go ahead, a China biotech notches a first in cell therapy testing - Hop...Leather_Landscape_20190%42.3stem cell therapy2026-03-14↗
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233r/ATHXThe MultiStem stroke trials mentioned in a Chinese studyimz7230%142.3induced pluripotent stem cells2026-03-25↗
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234r/NeuronsToNirvanaAbstract; 🧬⚡ N2N Insight Brief 🔬🌀| Psilocin fosters neuroplasticity in iPSC-deri...NeuronsToNirvana30%42.3induced pluripotent stem cells2026-03-29↗
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235r/ATHXAstellas President: Regenerative medicine in Japan has entered a new phase with ...imz7230%142.3induced pluripotent stem cells2026-03-30↗
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236r/IndicKnowledgeSystemsThe Trembling Reed: Poison, Rain, and the Sacred Art of Arrow-Tempering in Vasis...Positive_Hat_541430%42.3induced pluripotent stem cells2026-03-23↗
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237r/kbeautyHas anyone tried stem cell skin treatments in Seoul?Lonely-Jackfruit-54630%42.3stem cell therapy2026-03-09↗
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238r/10xPennyStocks$ADIA NEWS. Adia Nutrition, Inc. Reports Strong Revenue Growth in 2025 Annual Re...Loud-Relative-608430%42.3regenerative medicine2026-04-01↗
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239r/ReverseRhinoplastyRegenerative medicine in revision rhinoplastyhanginaroundthistown30%42.3regenerative medicine2026-03-05↗
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240r/AskDocsLikelihood of gallstones 9 years after a lap chole?throwra_103550210%442.0induced pluripotent stem cells2026-03-29↗
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u/Puzzled-Science-1870It's possible but rare. Sometimes people rarely form gallstones in their bile ducts even after cholecystectomy. I'd get an MRCP to prove no bile duct stones, and if not, then it's most likely your alcohol use. Your alcohol use is more likely to be the cause of the pancreatitis, but not a bad idea to rule out residual stones. All the best.neutral1
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241r/TargetedSolutionsMind Control Tech w/ ReferencesSouthern_log56710%442.0induced pluripotent stem cells2026-03-15↗
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u/Bryan_TewUnderstanding the memory attacks (blocking your real memories & injecting false memories & motivational impulses) are key because if you do not recognize modification of your ‘active memory’ the system will cause you to briefly lose time perception which may be enough procedural [functional] disorientation to influence you to respond to an injected impulse or memory attack! It is possible for the RNM system to influence you to speak or act unwillingly or, at the very worst, without you knowing it. For example, if you are susceptible to the systems influences you may not realize that it is frequently or constantly influencing you to make minor choices. These motivational impulses can also be used to influence you in a manner that will give you the desire to speak, and I emphasize desire because you need to understand that these impulses will only make you feel the urge [at higher levels set by the attackers] or basic motivation [at baseline levels] to perform the tasks it is influencing you to do Now in combination with this motivation to speak or act the A I system uses past memory references to direct you ­ for example, your personal memory of turning to speak to your wife & the associated impulse ­& when you react to this influence the system will block your working memory while streaming the desired output which will result in you making one or more statements under the system’s control They will test this on you frequently with ‘word substitution’ and if you can learn to control this in thought then you can control it while speaking but you must learn to read active memory If you cannot recognize modification of your active memory then after the forced speech attack it is possible that you will have no recollection of making the statement As you learn to defeat the predictive capabilities of the system by reading active memory (testing and validating your own thoughts) you will see their attempts to restrict your ‘reference choices’ will become increasingly evident and you will begin to perceive what I will describe as ‘functional duality’ [it might also be described as focal duality] within your working memory. The perps system’s prediction error rate will dramatically increase & its attempts to predict your thoughts or intentions will become humorous if not simply annoying Seeing the relationship between your own previous memory references and the systems output [which can be a specific memory or emotion previously captured by the RNM System and now replayed perpetually in your mind] is critical to understanding how to control & ultimately defeat ‘thought­ triggered’ attacks in addition to preventing the attackers from deceiving & manipulating you You should be able to redirect the system during ‘Formulation’ (collecting data by reading your mind) or prevent ‘Predictive Integration’ (interpretation of data from injected thoughts & impulses) altogether, but when you learn to stop integration, realize that the system will be waiting for completion & will ‘probe’ you for a response. It will begin to ‘inject’ again if you attempt to ignore it If successful , you will notice they will also abuse you in every way possible to convince you that they’re in control when you will be able to see clearly that they are nothing more than idiots who need to spend more time studying the systems they are abusing people with If the system’s suggestions are not acceptable to you [and they won’t be if you’re consistently blocking and/or redirecting it] then this will result in you making a continuous effort to counter the imposition of thoughts and impulses while contrasting you’re ‘working state’ to maintain active focus Although by cooperating & allowing the system to interpret & define your daily activity you may find that the suggestions become more tolerable as the system is designed to mimic your normal cognitive behavior, I would recommend not allowing this as you will tend to more readily accept the system’s influence, and the purpose of the system influencing you in this manner is to give the attackers the ability to restrict you at will & to allow them to deceive or manipulate you subconsciously You can only counter these restrictions if you are able to contrast the system’s influence from your own willful activity. Everyone who is hearing “V2K” is being monitored in this manner & being influenced in this way as well. The phrases you are hearing should be related to information captured during the ‘silent monitoring period’ & will eventually be used as the foundation for your endless verbal harassment What they do is a game of deception & manipulation, nothing more. Do not accept anything they say as truth & do not acknowledge anything the system interrogates you about as truth. The system will take random bits of anything it captures through your senses & fabricate stories which they will use to harass & interrogate you with no intention other than to distract & torture you into submission [to the sneutral2
u/Southern_log567⁠⁠⁠⁠Allan Frey – Microwave Auditory Effect 🔗 https://en.wikipedia.org/wiki/Microwave_auditory_effect ⁠⁠⁠⁠Pentagon Heartbeat Laser (remote biometrics) 🔗 https://www.technologyreview.com/2019/06/27/238884/the-pentagon-has-a-laser-that-can-identify-people-from-a-distanceby-their-heartbeat/ ⁠⁠⁠⁠New World Vistas – USAF Science 1994 (see pgs. 88–100) 🔗 https://apps.dtic.mil/sti/tr/pdf/ADA309597.pdf ⁠⁠⁠⁠Canadian Government – Havana Syndrome transparency 🔗 https://www.international.gc.ca/transparency-transparence/unexplained-havana-incidents-inexpliques-la-havane.aspx?lang=eng ⁠⁠⁠⁠Balaban et al. 2020 – Eye movement biomarkers in Havana Syndrome 🔗 https://pubmed.ncbi.nlm.nih.gov/32655474/ ⁠⁠⁠⁠MRI usage statistics in Canada 🔗 https://www.ncbi.nlm.nih.gov/books/NBK607341/ ⁠⁠⁠⁠JAMA – MRI Imaging studies on gray/white matter changes 🔗 https://jamanetwork.com/journals/jama/fullarticle/2738552 ⁠⁠⁠⁠John Norseen & Duncan Laurie – Biofusion neuroweapon theory 🔗 https://www.duncanlaurie.com/writing/outlaw_technology/03_krylov_space ⁠⁠⁠⁠Retina as a biological antenna (ResearchGate) 🔗 https://www.researchgate.net/publication/336408771_Fractal_and_periodical_biological_antennas_Hidden_topologies_in_DNA_wasps_and_retina_in_the_eye ⁠⁠⁠⁠Cavity resonators and quantum frequency generation 🔗 https://www.sciencedirect.com/science/article/abs/pii/0370269379902272 ⁠⁠⁠⁠Cavity resonators and quantum frequency generation 🔗 https://www.sciencedirect.com/science/article/abs/pii/0370269379902272 ⁠⁠⁠⁠Microtubules – Structure and function 🔗 https://en.wikipedia.org/wiki/Microtubule ⁠⁠⁠⁠Quantum Entanglement – Basic overview 🔗 https://en.wikipedia.org/wiki/Quantum_entanglement ⁠⁠⁠⁠Remote NIRS (Near-Infrared Spectroscopy) for brain monitoring 🔗 https://pubmed.ncbi.nlm.nih.gov/36965063/ ⁠⁠⁠⁠Geostationary IR/NIR imaging applications 🔗 https://pubmed.ncbi.nlm.nih.gov/34335997/ ⁠⁠⁠⁠Cosic (2017) – Resonant Recognition Model (Tesla bioresonance) 🔗 https://www.researchgate.net/publication/318306399_Tesla_Bioresonances_and_Resonant_Recognition_Model ⁠⁠⁠⁠Caceres (2018) – Zika virus and RRM 🔗 https://www.researchgate.net/publication/330748880_Zika_Virus_Viewed_Through_the_Resonant_Recognition_Model_Unraveling_New_Avenues_for_Understanding_and_Managing_a_Serious_Threat ⁠⁠⁠⁠Photon entanglement through brain tissue 🔗 https://www.academia.edu/30547093/Photon_Entanglement_Through_Brain_Tissue ⁠⁠⁠⁠Measuring protein concentrations with entangled photons 🔗 https://www.academia.edu/60782774/Measuring_protein_concentration_with_entangled_photons ⁠⁠⁠⁠Persinger – Thixotropic water properties and EM field interaction 🔗 https://www.mdpi.com/1099-4300/17/9/6200 ⁠⁠⁠⁠Resonance modeling of JAK–STAT signaling (Persinger 2015) 🔗 https://www.researchgate.net/publication/274096152_Novel_Cosic_resonance_standing_wave_solutions_for_components_of_the_JAK-STAT_cellular_signaling_pathway_A_convergence_of_spectral_density_profiles ⁠⁠⁠⁠Entangled photons for quantum communication & measurement 🔗 https://www.academia.edu/73224923/Quantum_entangle_photon_and_applications_in_communication_and_measurement ⁠⁠⁠⁠Cryogenic microwave pulse generator for superconducting quantum computing 🔗 https://www.researchgate.net/publication/382296421_A_cryogenic_on-chip_microwave_pulse_generator_for_large-scale_superconducting_quantum_computing ⁠⁠⁠⁠Dr. James Giordano – Neurowarfare lecture (YouTube) 🔗 https://www.youtube.com/watch?v=N02SK9yd60s&t=1276s ⁠⁠⁠⁠The Unspoken Arms Race: Neurowarfare 🔗 https://www.researchgate.net/publication/355348195_The_Unspoken_Arms_Race_Neurowarfareneutral1
u/DribblingJonGood work. But seriously.  The mechanisms behind this shouldn't matter. The governments of the world are litterally ignoring tens of thousands of people reporting the exact same thing. I even have stuff like two of my friends mysteriously developing these voices at the same time as I did. Then the voices told them stuff like "Go pick up Bradley" at the same time as I was told "Your friends will be here in 30 minutes to pick you up." Unfortunately that's our word against hundreds of years of medical science saying "hearing voices means you're losing it." Yet I have this corroborated thing, that if true would be the largest human rights violation of all time that causes so many people so much suffering. Puts us through hell. Yet they just ignore it.negative1
u/targeting_CameronI have been getting an oily substance coming out of both eyes lately. Do I go to the dr.? ?negative1
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242r/UPSCmosquito mention krna bhul gye lolsnoe_lungcancer220%541.2induced pluripotent stem cells2026-03-08↗
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u/mitchellwolverineToxic males are in demand everywherenegative8
u/Wise_Shake_5630They know what they’re doing 😌positive2
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243r/ATHXJapan's Teijin to offer personal iPS service with production cost of $63Kimz7210%341.1induced pluripotent stem cells2026-03-17↗
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u/imz72March 17, 2026 Personal iPSC Service to Launch with Production Cost in the 10-Million-Yen Range ... Fees will initially consist of the manufacturing cost — set in the 10-million-yen range — plus separate storage charges depending on the duration. The partners aim to bring prices down over time through operational efficiencies. The companies target 20 orders in FY2026 and 1,000 by FY2030, equivalent to sales of roughly 10 billion yen [$63 million]. ... The service targets individuals — both in and outside Japan — willing to invest heavily in personal health. Nakagawa said the service could gain traction particularly in multi-ethnic markets such as the US, where differences in HLA types can make matching donor-derived iPSCs more difficult. Nakagawa noted that the new pricing marks a sharp drop from earlier estimates of around 50 million yen [$315K] for producing autologous iPSCs. Even so, Teijin Regenet President Yasushi Tanaka acknowledged the cost remains “somewhat high” for private individuals, saying the companies will work to reduce prices through automation and labor-saving manufacturing systems. Nakagawa added that advances in manufacturing know-how, economies of scale, and automated quality-controlled processes should also help lower costs over time. https://pj.jiho.jp/article/254973neutral1
u/imz72And 2 short videos from a Chilean TV channel, which can be viewed with English dubbing and subtitles: March 17, 2026 Japan authorizes the first regenerative therapy for Parkinson's disease using pluripotent cells https://youtu.be/QCyz6xFs0kA Innovative stem cell therapy for Parkinson's disease presented https://youtu.be/7ZXo9_SmLVcneutral1
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244r/PICLDextrose vs Stem Cells - Inflammatory ResponsesVarious_Shape167810%341.1PRP knee treatment2026-03-20↗
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u/Chris457821Dextrose prolotherapy works by injecting a substance that causes local cell death and injury because it's hypertonic (more concentrated than the body's normal fluids). For most patients, the inflammatory response would last about a week and then positive results are seen in 4-6 weeks with complete healing in months. These healing times are generally shorter in most patients because the effect is small (small amounts of local cell injury, inflammation, small amounts of local repair). Bone marrow concentrate containing mesenchymal stem cells initiates repair through paracrine signaling and coordinating a repair response. The repair initiated is generally bigger than prolotherapy. Recovery from the ePICL procedure is very different because unlike in simple prolo where only one thing (mid-line posterior ligaments) is treated, in this procedure multiple structures are treated (ligaments, joints, nerves), each that heal on different timelines. To see all of the structures that are commonly treated, see: https://youtu.be/MuX6LRH6EmM?si=PUDi3UNesRhQey7X2
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245r/u/pytersdmfThe Living Lens: How Regenerative Medicine is Rebuilding the Windows to Our Worl...pytersdmf20%40.5induced pluripotent stem cells2026-03-13↗
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246r/radicalmentalhealth"What If the U.K. Had Free Speech?" + 30 articlesReferendumAutonomic20%40.5induced pluripotent stem cells2026-04-03↗
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247r/PICLHello Dr. Centeno!Rare-Lingonberry-18220%140.5induced pluripotent stem cells2026-03-17↗
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u/Chris45782199% of the time, things that work in rabbits don't work in people, so we will have to see how that plays out. The key piece of disc height is actually GAGs which hold onto water, so based on that, this will likely not be that effective.neutral1
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248r/HumanMicrobiomeThe top new and updated threads in the last week on the Human Microbiome ForumAutoModerator20%140.5induced pluripotent stem cells2026-03-09↗
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u/AutoModeratorReddit is no longer a reliable place to create, host, and grow communities, so a new microbiome forum has been set up to be a more reliable location. If you have posted content on Reddit that you feel is worth preserving, it would be a good idea to post it on the new forum. The person who created this sub, and most of the content here, including the wiki, has moved to the new forum. You should be able to get better info & answers there. It's easy to stay on reddit but the quality of content on most subs is extremely poor. Most of the advice given on reddit is misinformation. You're welcome to post your content there and then link to it here for higher visibility. Our primary goal will remain as stopping the widespread misinformation on the topic of the microbiome. Since we no longer have someone dedicated to correcting and preventing misinformation, comments and posts here will require pre-approval. Some types of content (questions) may be restricted completely since we no longer have reliable people dedicated to providing evidence-based answers. But you're welcome to ask your questions on the new forum and post the link here. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.negative
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249r/StemCellsForumWhat are your thoughts on stem cell therapy for chronic diseases?Quick_Rutabaga_935620%140.5stem cell therapy2026-03-20↗
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u/GordianNaughtIt won't be mainstream in the United States any time soon. In other countries the treatments are widely accepted1
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250r/backpainCan stem cell therapy actually heal injuries instead of just hiding the pain?Quick_Rutabaga_935620%140.5stem cell therapy2026-03-15↗
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u/AutoModeratorPlease check out the r/backpain wiki for some first steps for new low back pain & FAQs [ https://www.reddit.com/r/backpain/wiki/index/ ] PLEASE NOTE: When Asking for help it is up to you to recognize when to seek medical attention. Anyone giving advice in this group is doing so from anecdotes and holds no liability. Seek advice here at your own risk. Remember to be kind & respectful. There is always a way We are rooting for your success Posts and replies that do NOT show kindness and empathy towards others will be deleted. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.1
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251r/IHaveParkinsonsStem cell transplants are sounding like the best prospect yet. I’d love to see t...dannieandme20%40.5stem cell therapy2026-03-20↗
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252r/TheCreativeContentTop Benefits of Adult Stem Cell Therapy in Chicago for Joint Painerepresent20%40.5stem cell therapy2026-03-14↗
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253r/Science_IndiaStem Cell Therapy Enables Two Women With Asherman's Syndrome To Become MothersVCardBGone20%40.5stem cell therapy2026-03-12↗
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254r/KneeInjuriesWhat helped you with your pain?ExternalSignal923920%140.5PRP knee treatment2026-03-09↗
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u/MechanicalGodzillaIf she has osteoarthritis, her options are fairly limited. Typically a joint replacement will make worlds of difference (I have an artificial knee). There are newer forms of treatment, like microfracture procedures and PRP/stem cell treatments, but those seem to be more recommended in the early stages of cartilage degeneration. Otherwise, maintaining a healthy weight will reduce joint stress.1
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255r/stemcellsMenstrual Blood-Derived Stem CellsPeachy700220%40.5subreddit:stemcells2026-04-02↗
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256r/CervicalinstabilityIs PRP and prolotheraphy help for CCI? And do we need to get align first before ...Deltaanchor40%3339.9PRP knee treatment2026-03-25↗
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u/PenniieI had PRP in my neck and didnt notice any difference, felt like i threw away $1,300. The only thing that has helped my neck pain is nerve ablation, I get it done every 6ish months. I have alot of hypermobility in my neck but no obvious structural issues to my spine in that area, so its mostly ligament issues, inflammation, and nerve irritation, but it causes severe issues for me.5
u/Regular_Road3045Helped me majorly (stem cells and prp) I didn’t go down the alignment AO route4
u/Responsible-Sell5834You do not need an alignment before treatment, or ever to be honest. I would ask your PRP MD if working with a chiropractor is safe before having any adjustments done on your neck, people with CCI are at a higher risk for being injured by adjustments.3
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257r/GCSEAQA Biology mark schemeAdditional_Low_8410%239.8induced pluripotent stem cells2026-04-02↗
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u/PureBelt8770bracket r just extra info - not mandatory - its jst context of the questionneutral1
u/Legitimate_Yam3395Brackets mean extra info not necessarynegative1
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258r/ProductivitycafeAudifort Reviews and ComplaintS:~ An Honest Customer 2026 Review!Practical-songs10%239.8induced pluripotent stem cells2026-03-14↗
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u/whitswhisperear fatigue from late night podcasts is already creeping in at my age. Solid breakdown, might stack this to keep focus locked during study grindsneutral1
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259r/stemcellsISO Stem Cells. NYStill-Arugula577310%239.8stem cell therapy2026-03-18↗
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u/Primary-Ruin8830I was involved in a study here in Houston For my TBI, where they injected, stem cells from my own adipose tissue via IV. I think it has helped me out 10 to 15% I am Looking into more stem cell treatment. Let me know what you find.1
u/Still-Arugula5773I heard Dr. Calapai in Garden City NY is the go-to for stem cells, alternative and regenerative medicines. Will have to check him out.1
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260r/AskDocsHurt my knee weeks ago and doctors treatment plan hasn’t helped.Kyzer57710%239.8PRP knee treatment2026-04-03↗
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u/DerVogelMannShould I be concerned and go to a hospital for further testing or continue following my Doctors original treatment plan? Neither, this is not an emergency and does not belong in the emergency department. You should follow up with your doctor. Medicine is often iterative, we have multiple lines of therapy/investigations. It would be inappropriate to order things like order a knee MRI every time someone bungs up their knee as 98% of the time most MSK injuries like you had will resolve with time. It's not "well, X doctor said do this and it didn't work so they're useless". Follow up, as the current situation is different than it was 3 weeks ago as it didn't get better.2
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261r/Scholar[Article] Pyarthrosis of the Knee Treatment ConsiderationsSubstantialFinish95710%239.8PRP knee treatment2026-03-29↗
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262r/Scholar[Article] The chimera of reaching a universal consensus on platelet-rich plasma ...Master-Director-92910%239.8PRP knee treatment2026-03-23↗
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u/GD4E1https://www.mediafire.com/file/z9ho5ao97cfpx1x/The_chimera_of_reaching_a_universal_consensus_on_platelet-rich_plasma_treatment_for_knee_osteoarthritis__a_review_of_recent_consensus_statements_and_e.pdf/file1
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263r/cervical_instabilityHas anyone been to Dr. Stogicza for treatment recently? I want to know how you a...Tricky_Context28870%1239.0PRP knee treatment2026-03-17↗
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u/JewaldGood question, sorry I've been in and out of the sub for a bit, challenging year so far. She and I started the 2nd interview a few days ago but she had internet problems so we rescheduled. In the meantime, somebody sent me an interesting article... Stogicza did PRP PICL on an olympic athlete who missed the PAris olympics because of CCI, here's the article tho the translation is rough, hungarian and english are super different: https://www.blikk.hu/sport/benkucs-kira-roxana-betegseg-gyujtes/lkqqk8h Somebody on the sub saw that and reached out to the olympian directly (we should refrain from that I think, high chance she gets overwhelmed) and she said: "I'm able to move around again, I'm back to training, and I'm already preparing for my next competition. I can live my everyday life again, which I'm grateful for thanks to the interventions I had" Which honestly almost brings a tear to my eye just re-reading it. Glad we have innovators like Stogicza and Centeno out there! Rooting for her, I hope she keeps improving. We need more success stories. <image>7
u/Difficult-Prize-8419I am a patient of stogicza, I took a break from social media for a while. I did not have much improvement after the second picl the chiropractor said I was ready for neckslevel exercises so I got one (bloody expensive) and it made me worse. I now think because my scm muscles have been too short for over a decade in a very bad forward head posture. my neck gets too much resistance from those muscles so the ligaments are not healing as tightly as they should with my being unable to correct my curve properly by relaxing and lengthening those muscles first ! but that's just my new theory. I am going back for a 3rd round and am going to ask her about that. meanwhile I am doing stretches and massaging the scm muscles and its still going well not causing disastrous set backs yet 😬 the only thing I am angry about in all this is that I had to figure it out myself, again ! and that knowing my symptoms neither Innis or Stogicza told me those are known symptoms of those muscles being too short and tight, they knew the symptoms gave me a lot of anxiety they could have told me this, and given me appropriate exercises but nooo I had to find out from a youtube fisio therapist that randomly showed up on my feed ! I think they underestimate the force those muscles can exert in that imbalance perhaps ? or overestimate the ligaments strength in healing and pulling everything back in position ? I am going to ask both when I see them again in a month I dont see any other reason why I am not healing as well as others, other than the comorbidity of forward head posture, when my body is as capable of healing and healing well at that. in the 4 years bedboud I have had corona and the flu and had a bladder infection even a big operation to remove a massive terratoma and I healed really well and fast from all of those things so why not this ! If they do underestimate my teckneck than why !!? sorry about the rant 😅😬 I will get back to you guys when I have some answers3
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264r/NooTopicsCan adult neurogenesis be done in order parts of the brain with this strat? (A n...makefriends420170%338.3induced pluripotent stem cells2026-03-03↗
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u/makefriends420Ultimately, this work has demonstrated an improved protocol for generating all major hippocampal subtypes from hPSCs. Not only does this approach generate the longelusive CA1 subtype that has been missing from previous protocols, but the method is able to produce region-specific astrocytes. The rich electrophysiological properties of the neural cultures were found to be sensitive to morphology (monolayer vs organoid) and astrocyte to neuron ratio. While significant work remains to elucidate the complex workings of the hippocampus, the individual cell types, and understand inter-region interactions, the ability to culture a more diverse array of neural subtypes will be an invaluable tool for future research.positive3
u/grokon123Explain like I’m retarded. What’s the protocol? ?negative1
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265r/StargateSG1Let's talk about Daniel Jackson (Long and spoilers, duh)Proxy_Janewbeginning40%1938.1regenerative medicine2026-03-16↗
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u/freehotsaucedragonYo, that was a wall of text that would make even Carter blush. I skimmed through it, I have some small thoughts. Daniel is annoying bleeding heart that can’t see past his own flawed perspective. However, I think there are times where the writers are against him because if he succeeded the SGC would get a over powered ally like Reese. This would severely undermined the threats the SGC faces. The sarcophagus example is similar to when O’Neill decided to not let the Eurondans survive the bombing because they were racist and attempted a genocide in the episode “The other side.” Yes the technology is advanced but allowing a war criminal to live is too high a moral burden to bare. I thought Jonas Quinn was a good replacement, but if you are looking for non team members the Tollan Narim would be a good choice. He would be a great moral compass but less bleeding heart. Great technical knowledge but not a great fighter or strategist.3
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u/Proxy_JanewbeginningA lot was accidentally deleted by a cat on the keyboard, here is what was able to be saved: https://www.dropbox.com/scl/fi/fyxip7qssp1jeib3ojvcs/Daniel.txt?rlkey=un9ilc1ch0j0rihnq9o327756&st=sbr7wsmj&dl=01
u/Proxy_JanewbeginningApparently nobody has anything to add lol1
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266r/ProactiveHealthJapan just approved the world’s first treatments made from reprogrammed human ce...DadStrengthDaily10%37.5induced pluripotent stem cells2026-03-14↗
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267r/Scholar[Article] Comparative Histological and Immunohistochemical Study on the Effect o...rimeldemiel1310%37.5induced pluripotent stem cells2026-03-14↗
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268r/KeltoiWellnessThe 6 most important lessons about belly fat (and how to lose it)markoj2210%37.5induced pluripotent stem cells2026-03-25↗
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269r/PennystockCBD Life Sciences Inc. (CBDL) Announces CBG Emerges as a Promising Focus in Canc...louied9110%37.5induced pluripotent stem cells2026-03-24↗
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270r/RNStudentResourcesWGU D027 - Advanced Pathopharmacological Foundations OA 1st Attempt 2026.CertifiedRN10110%37.5induced pluripotent stem cells2026-03-18↗
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271r/ScienceBioTechnologyPeptides for Muscle Growth: A Preclinical Literature Review (CJC/Ipamorelin, PEG...jimmytwoshoes42010%37.5induced pluripotent stem cells2026-03-17↗
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272r/jenova_aiBest AI for Grading Assistant: Transform Assessment Workflows and Reclaim 6+ Wee...Rude-Result736210%37.5induced pluripotent stem cells2026-03-08↗
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273r/OrthopedicsChronic reactive synovitis after meniscus surgery – stem cells or partial synove...Queasy_Pea493010%137.5stem cell therapy2026-03-29↗
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u/SeL-MoGRCForget stem cells, as helpful as placebo. Do you have underlying connective tissue disease? 'Chronic reactive inflammatory synovitis' is a throwaway term used by the unskilled to explain a patients poor outcome. Synovectomy has limited indications. Age, sex, occupation, BMI, xrays would help me give you a better explanation.1
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274r/WealthyPFSaw Reddit post on stem cell travel vs local care—hope meets budgetjaredscrawford10%37.5stem cell therapy2026-03-24↗
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275r/BiohackersAnonymous Stem Cell SurveyDifferent_Cancel_62610%137.5stem cell therapy2026-03-10↗
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276r/PrefectContentThe Future of Pain Treatment: Stem Cell Therapy Clinics in Chicagoerepresent10%37.5stem cell therapy2026-03-14↗
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277r/TheWideContentIs Stem Cell Therapy in Chicago Right for You? Everything You Need to Knowerepresent10%37.5stem cell therapy2026-03-14↗
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278r/PrefectContentStem Cell Therapy Chicago: Can It Help You Avoid Surgery?erepresent10%37.5stem cell therapy2026-03-14↗
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279r/TheWideContentStem Cell Therapy Chicago: Benefits, Process, and What to Expect from Adult Stem...erepresent10%37.5stem cell therapy2026-03-14↗
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280r/TheCreativeContentHow Stem Cell Therapy in Chicago Is Transforming Regenerative Medicineerepresent10%37.5stem cell therapy2026-03-14↗
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281r/PrefectContentStem Cell Therapy Chicago: A Non-Surgical Option for Joint and Tissue Repairerepresent10%37.5stem cell therapy2026-03-14↗
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282r/TheWideContentWhy More Patients in Chicago Are Choosing Stem Cell Therapy for Pain Relieferepresent10%37.5stem cell therapy2026-03-14↗
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283r/TheCreativeContentStem Cell Therapy in Chicago: A Modern Solution for Chronic Pain and Joint Injur...erepresent10%37.5stem cell therapy2026-03-14↗
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284r/PrefectContentAdult Stem Cell Therapy in Chicago: How Regenerative Medicine Can Help Heal Join...erepresent10%37.5stem cell therapy2026-03-14↗
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285r/NoFilterNews/r/worldnews - https://realmwire.com/japan-approves-two-groundbreaking-stem-cell...Faction_Chief10%37.5stem cell therapy2026-03-06↗
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286r/AskDoctorSmeeeeAnonymous Stem Cell SurveyDifferent_Cancel_62610%37.5stem cell therapy2026-03-05↗
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287r/Pennystock$ADIA News out yesterday was well received..closed up 29 percent.. News came out...Tommyboytrader12310%37.5regenerative medicine2026-04-02↗
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288r/wallstreet$ADIA News out yesterday was well received..closed up 29 percent.. News came out...Tommyboytrader12310%37.5regenerative medicine2026-04-02↗
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289r/ScienceNcoolThingsCalifornia Institute for Regenerative Medicine board approves a $100,000,000 rar...sillychillly10%137.5regenerative medicine2026-03-23↗
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u/sillychillly"As many as 1 in 10 people in the U.S. has a rare disease, many of which have no known cure. A new program by the California Institute for Regenerative Medicine (CIRM) could change this by funding novel ways to develop multiple genetic therapies for multiple rare diseases at the same time. The new rare disease funding program approved by the board will allocate $100 million over two years to support multiple platform technologies for rare diseases. These platforms each represent one approach that could ultimately result in treatments for many diseases. That’s good news for those patients and their families who might otherwise have no options. This new approach for developing therapies for rare diseases is known as the Rare Disease Acceleration Platform and Innovation and Delivery (RAPID). “RAPID is designed to fundamentally reshape how we advance treatments for people with rare diseases,” said Shyam Patel, PhD, CIRM Associate Vice President of Preclinical Development. “By focusing on scalable platform technologies, we’re accelerating individual projects while building an infrastructure that enables faster, more efficient development across entire categories of genetic conditions. These therapies not only have the potential to reduce lifetime healthcare costs but also will streamline the path of therapies to the clinic and ultimately ensure that promising therapies reach patients who otherwise have no options.”1
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290r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-25↗
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291r/moneymachinestocksWhat If Humans Could Regenerate Like Animals? Exploring the Science and Potentia...mm_newsletter10%137.5regenerative medicine2026-03-14↗
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u/mm_newsletterSource: https://www.usatoday.com/story/money/2025/06/28/stock-market-sp-500-forecast-2025-tariffs-recession/84353446007/1
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292r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-20↗
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293r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-18↗
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294r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-18↗
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295r/FloridaPRP👋 Welcome to r/FloridaPRP - Introduce Yourself and Read First!Beginning_Army288910%137.5PRP knee treatment2026-03-06↗
commentercommentsentimentupvotes
u/Beginning_Army2889From what I’ve seen, knee arthritis and tendon injuries seem to be the most common reasons people try PRP. Curious if that matches everyone else's experience.1
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296r/AskDocsGeneral question for knees, and self treatment. 45yo, male.agent_uno10%137.5PRP knee treatment2026-04-01↗
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u/AutoModeratorThank you for your submission. Please note that a response does not constitute a doctor-patient relationship. This subreddit is for informal second opinions and casual information. The mod team does their best to remove bad information, but we do not catch all of it. Always visit a doctor in real life if you have any concerns about your health. Never use this subreddit as your first and final source of information regarding your question. By posting, you are agreeing to our Terms of Use and understand that all information is taken at your own risk. Reply here if you are an unverified user wishing to give advice. Top level comments by laypeople are automatically removed. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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297r/DplushealthPRP Therapy for Hair and Skin: What You Need to Know Before Starting TreatmentLoud_Reference835110%37.5PRP knee treatment2026-03-24↗
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298r/ChicLifeClubAnyone here tried non-surgical treatments for chronic knee pain?WorkingRush190810%37.5PRP knee treatment2026-03-24↗
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299r/KneeInjuriesWhat’s next? Had ACL done 15 years ago, the MCL and scar tissue removed, with PR...ProfessionJolly401310%37.5PRP knee treatment2026-03-21↗
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300r/ACLPRP - shot in knee cavity and VMOFantastic_Silver_37010%37.5PRP knee treatment2026-03-18↗
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301r/HealthCareExpertsIndiTrusted Knee Pain Treatment in Navi MumbaiSweet_Promotion141110%37.5PRP knee treatment2026-03-16↗
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302r/HealthCareExpertsIndiUnderstanding PRP Hair Treatment Cost in Andheri for Effective ResultsSweet_Promotion141110%37.5PRP knee treatment2026-03-05↗
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303r/hospitalistVirus - PropagationNeither-Objective2540%137.5induced pluripotent stem cells2026-04-01↗
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u/Emergency-Cold7615But do the hosts turn into zombies? ?negative1
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304r/tryingtoconceiveIs stem cell therapy for autism even worth looking into?lunefaeryy0%137.5stem cell therapy2026-03-30↗
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u/AutoModeratorHi! Welcome to r/tryingtoconceive! Please be sure that you have read our rules before posting or commenting in this sub. Multiple rule breaks may result in a ban from this community. Please note: Discussion of current pregnancy, pregnancy announcements, and photos of HPT’s are not allowed outside of the designated thread. (“Weekly BFP/Line Eyes Post”). Don't see your post? Our automod filters posts due to keywords, images, and low post or comment karma. If your post is not showing up right away, it is likely awaiting moderator approval. Please be patient as we are not always online but will have your post approved or removed ASAP. We typically let you know why a post was removed. You may find our PSA post regarding the luteal phase helpful if you find yourself symptom spotting and wondering what is going on. We also have a designated thread dedicated to discussing OPK's, general topics like the TWW (two week wait) that is pinned. New to OPKs? You may find our PSA post regarding OPKs/Ovulation Tests helpful if you are unsure if your test is positive or have questions about taking them. Please report any rule breaking. If you are unsure if it breaks the rules, report it and mods will review it or reach out to the moderators via Modmail. Remember to keep discussions civil. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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305r/newjerseyExploring Regenerative Medicine Options in NJ: Stem Cells, Exosomes, and Peptide...DecentDamage29200%37.5stem cell therapy2026-03-19↗
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306r/uflRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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307r/collegecompareRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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308r/rutgersRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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309r/askCardiologyAre there cardiologists that specialize regenerative medicine?SoManyQuestions52000%37.5regenerative medicine2026-03-26↗
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310r/stemcellsAnonymous Stem Cell SurveyDifferent_Cancel_62610%137.4stem cell therapy2026-03-03↗
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u/Thoreau80How does it help?1
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311r/stemcellsStem Cells for Fetusesswarrenlawrence10%37.4stem cell therapy2026-03-03↗
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312r/regenerativemedicineType 2 Diabetes Mellitus (T2DM) Treatment Using Standardized Regenerative Medici...advancells6k60%35.3subreddit:regenerativemedicine2020-01-04↗
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313r/Scholar[Article] Maintenance of Human Naïve Pluripotent Stem Cellsxxx_laevis10%231.8induced pluripotent stem cells2026-03-20↗
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u/AutoModeratorDear /u/xxx_laevis, Thank you for your submission! Please read the following. Reply to the fulfiller with "thanks solution verified" once your request has been found. Chances are high that the article you're looking for is already available! Search for its DOI/PMID/title here, or DOI/PMID/URL here. If this answers your request, please flair your post as Found. If your article is not available via Sci-Hub/Libgen, be sure to provide us a full citation, a DOI or PMID or at least the ISSN of the journal, and a link to the paywall or PubMed record or, if you can't find one, a link to the journal's WorldCat record. If your article is not available online, flair your post as Needs Digitizing. If your request isn't urgent, please try an interlibrary loan (ILL) instead. ILL avoids potential copyright issues and lets libraries know which subscriptions are useful. If you receive a PM from someone asking you to pay for the article, please understand that this is against the spirit of the sub and we do not condone this. Message the mods if you believe it to be a scam. Fulfill some requests while you wait for yours! I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral1
u/GD4E1https://www.mediafire.com/file/0v4xly8a30ujjod/978-1-0716-1908-7.pdf/fileneutral1
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314r/RimWorldI need MORE power. TELL ME HOW THIS INSTANT. (Please!)bonisbestboy0%1731.7regenerative medicine2026-03-17↗
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u/Tight_Good8140Don’t use smoke leaf it sucks4
u/Souls_for_sale_nowvoid3
u/freedomfire99Deathless gene, psycaster stuff, limb regeneration!2
u/Super-Contest7765And here is me, looking for mods that not only enhance the pawns, but allow us to give then like 2 hearts, 3 lungs, 3 kidneys and so on2
u/bonisbestboy[deleted]1
u/killchopdeluxe666What's that limb graphic from?1
u/laststand16can you share the mods you use?1
u/totallymarcBeyond our Reach Tenebral / Quasar level bionics. Haven’t yet gotten the tech needed for them but I was attacked by the Tenebral-level faction and I can safely say their bionics and gear are absolutely busted.1
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315r/upliftingtrendsJapan gives green light to first-of-their-kind stem cell therapieshata3970%31.0stem cell therapy2026-03-18↗
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316r/stemcellsWhat is your take on stem cell therapy for dementia?Obvious-SnowyDust20%430.0stem cell therapy2026-03-24↗
commentercommentsentimentupvotes
u/GordianNaughtTBI yes....dementia no.3
u/DeyabMDDementia is a symptom that may be from several very different diseases that one solution (stem cell) won't be the answer for them all3
u/mother_jeongyeonIt works but you need specialized neurological stem cells for that, mesenchymal won’t do anything1
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317r/McatSection bank 1 B/B questionMaximum-Fishing-898930%127.3induced pluripotent stem cells2026-04-02↗
commentercommentsentimentupvotes
u/SatisfactionOk6367For the question don’t worry about tnfalpha, just strictly look at the graph and compare. Of all the results, RBSP has the most apoptosis meaning most dead cells meaning the least fluorescence. Don’t read too much into the question, just look at the graph and solely interpret what it means. Only if it mentioned TNFalpha would you interpret the results differently, but this question is more straightforward. Lmk if that helps!negative2
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318r/ACLWhat do you guys think about PRP treatment for partial ACL tear?Parking_Clock347330%27.3PRP knee treatment2026-03-27↗
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319r/DailyslantInteresting this Pluripotent Stem Cells isOGBFREE20%25.5induced pluripotent stem cells2026-04-01↗
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320r/CervicalinstabilityHas anyone been to Dr. Stogicza for treatment recently? I want to know how you a...Tricky_Context28820%25.5PRP knee treatment2026-03-17↗
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321r/stemcellsDoes anyone know of anywhere in Illinois that provides stem cell therapy? I have...ethankrafft10%224.8stem cell therapy2026-03-30↗
commentercommentsentimentupvotes
u/Tight_Stable_9355https://duckduckgo.com/?q=reputable+stem+cell+therapy+in+illinois&ia=web1
u/FaithlessnessOdd1346You can send me a PM and I can get you in a call with a provider in your area1
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322r/ACLWhat do you guys think about PRP treatment for partial ACL tear?Parking_Clock347310%224.8PRP knee treatment2026-04-02↗
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u/OoElMaxioOI had prp to help tendon and cartilage. Did nothing to me, I'm still having pain for a lot of exercises. Prp injections were 9-10 months post op. Some people might have a different experience but I read that some people just doesn't feel anything better.2
u/BebuddylowTreatment waiting for a disease. And ready to lighten your wallet.1
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323r/ACLWhat do you guys think about PRP treatment for partial ACL tear?Parking_Clock347310%224.8PRP knee treatment2026-03-22↗
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u/Plenty-Bother-1794I got PRP injection directly into my quad graft during surgery. In your case, if you can afford it, why not. Send it!! Lol it can’t hurt to try.2
u/RacacooonieI think it’s worth a try. I got one and it helped reduce my pain for six months. If you’re trying to avoid surgery and or reduce inflammation it’s a good option. I ultimately ended up needing surgery for something else but my partial ACL tear did heal up without needing repair.1
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324r/RegenerateEverythingStem Cell Therapy Offers New Hope for Joint and Ligament InjuriesMargotli10%22.5stem cell therapy2026-03-27↗
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325r/RehealthMexico vs USA stem cell therapy – is it really worth traveling?Equal-Procedure585110%22.5stem cell therapy2026-03-20↗
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326r/udemyfreebiesStem Cell & Gene Therapy Online Coursesmartybrome10%22.5stem cell therapy2026-03-13↗
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327r/INErectileDysfunctionThank you STEM CELL THERAPY for fixing my Erectile Dysfunction Permanently. If y...ED_Healer10%22.5stem cell therapy2026-03-11↗
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328r/u/Calm-Blueberry-9835✨️China reports experimental stem-cell therapy restoring insulin production in s...Calm-Blueberry-983510%22.5stem cell therapy2026-03-04↗
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329r/QuantisnowCaribou Biosciences Announces the FDA Granted Regenerative Medicine Advanced The...Quantisnow10%22.5regenerative medicine2026-03-31↗
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330r/StockTitanCRBU | Caribou Biosciences Announces the FDA Granted Regenerative Medicine Advan...Stock_Titan10%22.5regenerative medicine2026-03-31↗
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331r/NetherlandsWorldCupMemphis Depay undergoes special knee treatment in Spain and returns to Corinthia...oranjemania10%22.5PRP knee treatment2026-04-01↗
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332r/DeepTissueMassageUKThis looks good!: Sports massage | back pain knee pain treatments | CoimbatoreDeepTissueMassage_10%122.5PRP knee treatment2026-03-24↗
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u/AutoModeratorWelcome to the deep tissue massage community. Share all your thoughts, experiences, and tips about all things deep tissue massage. Find lots of information about deep tissue ashiatsu massage in London here: Deep Tissue Massage London I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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333r/DoctorstoolboxUnderstanding Cyst on Knee Meniscus: Symptoms and Treatment Optionsdabudabulover10%22.5PRP knee treatment2026-03-23↗
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334r/DeepTissueMassageUKThis looks good!: Knee Pain Treatment NorthwichDeepTissueMassage_10%122.5PRP knee treatment2026-03-14↗
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u/AutoModeratorWelcome to the deep tissue massage community. Share all your thoughts, experiences, and tips about all things deep tissue massage. Find lots of information about deep tissue ashiatsu massage in London here: Deep Tissue Massage London I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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335r/stemcellsDeveloping cell therapies for chronic lumbar disc disease, aiming to offer a non...DisastrousBison60570%122.5subreddit:stemcells2026-04-03↗
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u/highDrugPrices4uBioRestorative Therapies is an absolutely terrible company. While they has a legitimate technology in the hypoxic culture protocol— which they licensed from Regenexx a decade and a half ago— they have completely failed to commercialize it. Their problem is that they rely on delusive financing. What that means is that they rely on hapless retail investors to bid up the share price so that they issue huge numbers of new shares to their financing partners, leaving the retail investors holding the bag. I don’t believe any company this irresponsible can be successful.negative1
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336r/ScienceFeed[News] - Stem cell therapies ‘come of age’ with two conditional approvals in Jap...eventdawdling10%22.4stem cell therapy2026-03-03↗