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Subreddit: r/ApoE4 clear

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Longevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...

DrKevinTran

52.5

2026-03-22

commenter	comment	sentiment	upvotes
u/eddyg987	Resovastatin does cross the bbb. ApoA1 can cross the bbb and can integrate itself onto an ldl particles thus making it them less dysfunctional. So hdl does matter for apoe4 carriers further evidence of this is the data from the ocetrapib phase 2 study that showed 20% less plaque formation. They(the authors of the study) claim direct obecetrapib interaction, but that’s wrong it’s the huge increase in apo a1 caused by the cetp inhibition.		3
u/CantaloupeNo3975	Is this the study referenced? If so, it looks like the participants with HMGCR SNPs had an average blood ldl of around 130mg/dl. Am I reading this correctly?		1