There was a very positive article posted a few weeks ago on lithium and lithium orotate, but here is a more measured analysis that I found informative. The TLDR is:
Given the negative meta-analysis, the absence of human orotate trials, the ecological associations that disappear after adjusting for metabolic confounders, and the unresolved safety questions, I do not currently recommend low-dose lithium supplementation for brain health.
https://drglorioso.substack.com/p/low-dose-lithium-for-brain-health
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u/rafiunixman
Sharing something I have been tracking that gets less attention in longevity discussions: the distinction between movement quantity and movement quality as neural aging markers. Most exercise research focuses on VO2max, step counts, or resistance training volume. A smaller but interesting body of work, much of it coming out of computational motor control research (Daniel Wolpert's group is one reference point, and separately the Feldenkrais research community), examines proprioceptive acuity and motor variability as proxies for neural reserve. The argument is that how many distinct movement patterns the nervous system can efficiently execute and update may be a more sensitive marker of brain age than any single fitness metric. Worth watching as the field moves toward biomarkers of functional neural age.
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u/LzzyHalesLegs
https://substack.com/@verdinlabbuck
Eric Verdin’s lab just started one
Aging Science News @AgingBiology, and fightaging.org for aging science news
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u/kpfleger
FYI, there's a relatively new but at the moment fairly active sub https://www.reddit.com/r/ProactiveHealth/ whose entire focus is lifestyle optimization for (long-term) health. Community description: "ProactiveHealth: A community focused on proactive, evidence-based health and performance. We discuss prevention, early detection, metabolic health, strength training, cardiovascular fitness, and longevity science. The goal: extend healthspan, not just lifespan." So that's another place besides this thread for these topics instead of being top-level threads on this sub.
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u/PumpALump
Fractionated blood plasma discovered by Katcher is the only longevity method that is actually of any interest to me.
But of course nobody wants it because it's not a diet and exercise regimen that seems "natural", nor is it an expensive drug that they can profit off of or gatekeep with a high price tag.