đź‘€
William Rassman, MD, an Amplifica co-founder, adds, “The results observed in the frontal temporal region are particularly encouraging, as this area has traditionally been one of the most challenging to demonstrate a clinical response. AMP-303’s potential to stimulate hair regrowth in this region underscores its unique potential and sets it apart from existing therapies. Findings from this initial clinical study offers renewed hope for patients struggling with hair loss that have historically been resistant to treatment.”
74
u/0zeto
So how does Ru58841 a topical anti androgen protect from androgenic alopecia then? No fr i get it, multiple pathways can be targeted but eh... androgens definitly are somewhat relevant
39
u/oartistadoespetaculo
5 years
37
u/Kamikazehog
Can I get a TLDR for the TLDW? Jk thanks for sharing
27
u/F0x_is_kill
Reminder that Hair loss forums have posts from 2005 saying "just 5 more years" btw
23
u/jeansarkozy1607
yeah and the fact its an injection is even better no topical to apply and at least maintenance but i will be fully bald by the time this come out ....
22
u/GRAND_Prep
I'll wait for the haircafe video
20
u/megaman2500
Verteporfin activates trps1 after wounding, dr longaker talks about it in this video presentation at at around 18:30 timestamp
https://youtu.be/CpfsAbOuOCY?si=Wp3aa2PMeaCTvlvw
Furthermore, this paper by shamik mascharak et al
Goes into it
https://pubmed.ncbi.nlm.nih.gov/35077667/
14
u/ItsToboLads
I'm getting flashbacks to brocolli boy
13
u/The_Cabal_
This guy again
13
u/LWJ748
A segment of the hair loss community reminds me of a segment in the fitness community. In fitness it's very well established what works. Yet you have a swath of people doing everything they can to avoid that while wondering why they don't get results. People seem to go out of their way to avoid anything DHT related. I started losing my hair in my early to mid 20s. I'm now in my 40s with a 20 year old hairline because of duta/min. Maybe something better will come along, but at present time you're losing gains avoiding what works.
9
u/Jrlu92
Let me guess, there’s a mouse out there looking like a young Rick James
7
u/miyeets
Good research.
I always had a problem with the "dht is the root cause crowd."
To me it's quite ovioious dht is just a part of the equation of hairloss and of course, if you disturb an equation with a 5ar inhibitor, it helps, but it's not the cause.
6
u/AppliedLaziness
They really did that guy dirty with the caption...
5
u/TerryMisery
Where did you read AMP-303 is osteopontin analog?
3
u/TwistingSerpent93
There is this study in which androgen sensitivity has been induced in mouse follicles, triggering miniaturization similar to that in MPB.
I'd hypothesize that if you took two healthy follicles from a man's scalp, one in the "androgen sensitive zone" and the other taken from the base of the back of the head, and implanted both of them in the same spot (let's say the upper back), the follicle extracted from the androgen sensitive zone would display profound miniaturization in relation to the other.
3
u/Quirky_Comfort_7083
Dgaf its not available yet.
3
u/Comfortable-Rock4349
Remindme! -1823 days
2
u/Zealousideal-Fox623
they went after my niggas nose
2
u/Own-Luck4169
Measurable increase in hair count. From what they say is nothing wow at all yet you talk as if this is the real cause and is not, I can tell you 100%. Why? Is simple, the moment they will understand the real cause they will say: Hey we tried to fix this and the moment we did it, all hair grew back. Saying that PP405 won t work and this one will is kinda troll since this one doesn t have any outstanding results as you can read on their page. I think both will work but don t expect wow results.
2
u/Volturmus
Thanks ChatGPT
2
u/benshiro93
Release date ?
1
u/farcedsed
Remindme! -3650 days
1
u/Ok-Neighborhood4798
If DHT is not the main cause of hairloss then why did it immediately stop after 2 weeks of me taking finasteride and slowly growing back now 9 months later?
1
u/wonderboylsd
I am not a professional in this field. Perhaps you are right. However, I fail to understand that if the effect of PP405 is extremely poor, why they have launched Phase III clinical trials and received such a substantial investment. Could it be that the purpose of this company is money - laundering? It won't be long before we obtain the results of the Phase II clinical trials. Let's wait and see. I hope you are wrong.
1
u/jasko666
Does this mean I can stop with Dutasteride?
1
u/ROCKSTAR_LH_MEN
Remindme! -365 days
1
u/Specialist-Escape300
but what pp405 do is to directly trigger the follicle stem cell
1
u/AloopOfLoops
AMP-303 is 15% regrowth. That is not so impressive.
I mean i guess it is okay compared to minoxidil.
We will have to see if more injections lead to more regrowth. If that it the case then it is interesting for real.
Would be great of someone would inject some Osteopontin in there scalp:
Buy it here freeze dried:
https://www.sigmaaldrich.com/SE/en/product/sigma/o4264
Dissolve the powder in a sterile saline solution. Then dissolve down to maybe 2 ng/ml (just guessing and i want to guess very low for "safety") then inject in to scalp.
The issue might be that real Osteopontin is a big molecule and might not diffuse very well. Where i assume AMP-303 is a smaller functional analog and not just pure Osteopontin. As that would make it better for injection and also make it patentable securing their money. Another issue is that large amounts of Osteopontin may be cancerogenic.
1
u/AutoModerator
It looks like this post is about Research/Science.
Before asking any questions,
Search the research archives for your topic.
Find new research and influential papers.
Try posting in the private community for deeper conversations: https://community.tressless.com/
If this post is not about scientific research, please downvote and report.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/Odd_Sir_8705
We have been 1 more year away for 10 years now….you know how long 5 more years away will be?
RemindMe! -7500 days
u/TheHeftyAccountant
I’ve been thinning leading up to and since swapping to Dutasteride about 1.8 years ago. I started PP405 8 months ago and had promising results for the first month but it’s since had no impact. Hoping this explains how my hair can continue thinning even though i’m on both a systemic and topical anti-androgen regime.
edit: lol, i meant pyri, not pp405. what a gaffe
Hi, i cant use minoxidil foam or topical on my head due to seborreic and Malassezia. My dermatologist said your hair loss is not AGA im thinking my hairloss is due to dermatit and malassezia want to ask you think that gel gonna help to recover my scalp?
3
u/Helpingmehelp
Nice work. Very interesting.
2
u/Zealousideal_Sun6495
Very interesting. What are your thoughts on copper peptides to support scalp health and possibly hair growth? (As an adjunct to fin/min ofcourse)
2
u/Ralphiedog11
Any way of getting this in the US?
1
u/Luke10191
Great content as always. Can you make a video regarding how a female should deal with androgenetic alopecia?
1
u/Alakagom
Is there any merit in introducing anti-inflammatory products without obvious inflammation in the scalp itself? Might not be visible but still affecting the hair and the stem cells in some way?
You mentioned Wnt/B-catenin modulators which we know has a role in hair growth regardless. To me it sounds like Pirfenidone might play a role in a Dutasteride/Minoxidil stack through its mechanistic process. Hair loss is clearly not just a DHT sensitivity.
It looks like this post is about Research/Science.
Before asking any questions,
Search the research archives for your topic.
Find new research and influential papers.
Try posting in the private community for deeper conversations: https://community.tressless.com/
If this post is not about scientific research, please downvote and report.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
u/jeansarkozy1607
could you make some pirfenidone with your own patented vehicle you use for minoxidil sulfate?
Did they actually complete a phase 2B? That’s just the financing announcement. It’s possible they were happy enough with 2A to just jump to 3
7
u/jgmcmillan
This press release is from October 2025. The meeting they were talking about in this article is AAD, the one that just happened on Saturday.
I think you somehow mistakenly thought this press release is new?
6
u/CyberBerserk
u/haircafe looks like you spoke early
3
u/smurfsays
Most likely they shared all the data they're going to share. The open-label extension was the post-dosing period up to day 84. That is the data that was shared at AAD. The 3-month treatment wording appears to be an error if you look at the secondary outcome measures. It clearly shows that the OLE is "To assess the concentration of PP405 in plasma" at 84 days, and the presented data corresponds with the total enrollment. I don't think anyone received 3 months of treatment.
Nothing is mentioned about presenting specific data from the trials… thinking they will just say “here’s how our product works, it had significant effects” and nothing new or outstanding.
15
u/Hotrock21
Someone posted this days ago. What people are doubting is that Pelage won’t have the peachy data everyone hopes they do.
12
u/Dry_Bunch_1105
Live stream that shit!
3
u/AutoModerator
It looks like this post is about Research/Science.
Before asking any questions,
Search the research archives for your topic.
Find new research and influential papers.
Try posting in the private community for deeper conversations: https://community.tressless.com/
If this post is not about scientific research, please downvote and report.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
They will and weren't lying. Their CMO even already said they wouldn't present the phase II results on this conference, but this is tressless so everyone gets crazy excited over nothing.
18
u/nanananana45
someone else posted in another thread that there is no phase 2b and they went straight to phase 3
EDIT: The link you provided is a post to an announcement about series b financing, and it mentions Phase 2a and phase 3 trials, but there's no mention of phase 2b. I could not find anything via a google search where Pelage has ever said there was 2b study in process or planned, and it was only speculated by this site and other hair loss posters theyd be in phase 2b late last year
11
u/trey_19833
So I’m not really concerned at all by this, it’s pretty standard stuff for drug development.
My problem is how everybody on Reddit is over hyping this treatment, and I’ve been around long enough to remember when they did this for CB-03-01 too. Some people were even saying it would be better than dutasteride.
The most likely outcome is that pp405 works as a hair growth stimulant, and probably slows balding.
It’s cool because it’s a novel mechanism and what makes this a good treatment is that it gives people alternatives.
That being said, I doubt it will work long term as a monotherapy but will be great to add to a stack.
For example, I tried 5AR inhibitors but I can’t tolerate them, so instead I run a stack of nizoral, pyrilutamide, minoxidil and alfatrodial and this has given me great maintenance.
The more new drugs we have, the more choices we have to mix and match stacks to tailor it to what’s tolerable for us as individuals which is a very good thing.
That’s good news, and the more tools we have, the more options we have to fight hairloss and we aren’t stuck with having to to either take finasteride/dutasteride or go bald.
That being said, pp405 will probably be good as a stack with other drugs, hell it may even work great with minoxidil because you have two hair growth stimulants with different mechanisms of action, but we will still need to target androgens.
If you can’t do that with a 5AR we now have pyrilutamide, CB-03-01, RU58841, and hopefully GT20029 in the future.
None of these will cure baldness, and none of these will work for everybody and all of these need to be started before you’re bald but every few years we get more options to choose from making treatment more widely available for different peoples personal body chemistry.
I don’t think pp405 is a flop, I think it will be a great addition in the future but I don’t think we’ll replace the need to inhibit androgens in the scalp ever because it’s an unavoidable issue.
10
u/Brilliant_Run3426
I agree was disappointed with today, but what they actually said was: "at a future medical meeting in 2026." Which does not specify today