Insane the amount of work that went into this. Will order to show support.
positive
20
u/caprisums
based
neutral
15
u/Sonnyshut
May the hairline be with you
neutral
14
u/DeanoPreston
There's speculation that this may reverse graying, too.
positive
6
u/Burntoutn3rd
This is an insane level of dedication coming out of a novel chemical vendor. Nothing but high praise here from someone on the academic research side.
positive
6
u/Big-Tooth1671
Look it research chems, what more can we ask of a company. I have as much faith as i can in there stuff for what it is .they try be as transparent as possible admit when they get it wrong big thumbs up from me im no expert so take it as it as i see it and not gospel great prices great products a little bit work on customer services in getting back quicker then there onto a winner .Im sure not easy getting reliable staff for these sort of things. for them to be spot on im sure our pockets get hit harder and we not all in a place to deal with it . I got banned from nootropcs for life no reason after asking why im sure its because i champion and tell people that i go everychem . Love acd856 favourite product sure it gave me mind set to get off long term opiods .
positive
5
u/Unlikely-Blacksmith1
Is there any signs of regrowth anywhere by using your product yet
neutral
3
u/Spare_Entry_2441
I want to get 1 which one should i get? and would it work for beards as well? ?
neutral
3
u/ThemeAppropriate575
Guys I have disorders and I can read what is posted here, can someone sum up what is written above? ?
neutral
3
u/Great_Cow6624
Where can i buy pp405? ?
negative
3
u/makefriends420
Hope we can figure out what is what, doesn't seem like figuring out the structure is as possible as it was with ACD.
negative
2
u/Kobiash1
Impressive work. Agreed with the red herrings though. Companies often file patents for hundreds of molecules to hide the real one. 2HEE or 3HP might just be analogs. However, synthesizing cyanoacrylates and pyrrolopyridines requires incredible precision. Impurities in grey market batches could cause scalp issues which would mimic hair loss rather than fix it. That would be a big red flag for me at this point because it's a best-guess, which carries the risk inherant with experimental chemicals and unknown toxicity, plus stability issues.
neutral
2
u/BrainWashedChimera
This is extremely impressive..
positive
2
u/Sufficient-Mall-4210
Is this true?
PP30 matches the public patent chemistry trail more closely than 3HP.
The main reasons are: • The public Pelage/UCLA chemistry points to a cyanoacrylate MPC-inhibitor scaffold with an azaindole/pyrrolopyridine-type core, not to a simple “3HP” concept. • PP30’s structure fits that published family better: it has the same broad azaindole/pyrrolopyridine + cyanoacrylate architecture and uses a 3,5-bis(trifluoromethyl)benzyl motif, which is closer to the public lead series. • The patent language explicitly allows prodrugs and specifically mentions acyloxy substituents such as acetyloxy, which makes PP30’s acetyloxyethyl ester look like a more natural patent-inspired delivery form. • I could not find 3-hydroxypropyl / 3HP specifically called out in the patent or the public medicinal-chemistry paper, so 3HP looks more like a looser guess built from the same general family rather than the strongest fit. • Even EveryChem says it does not know what the real PP405 uses and that its products are only examples based on public patents, so neither is confirmed — but PP30 is the closer match on paper.
So the shortest version is:
PP30 looks more likely than 3HP because it lines up better with the published MPC-inhibitor scaffold and with the patent’s prodrug/acyloxy clues. 3HP still looks related, but less specifically supported. ?
neutral
2
u/Unusual_Jackfruit146
Looking forward to hearing good news
positive
2
u/SoupBand
Is anyone trying it now? Please reply to this comment so I can better follow your changes LMAO ?
neutral
1
u/PuzzleheadedPeace360
Hi OP, Im new to all of this but wd like to try. I see two products; PP30 and 3HP. Which one should I pick and what is the dosage. thanks!
neutral
1
u/West_Marionberry_819
If you were to buy all three hair-regrowth treatments, would you apply them all back-to-back on the scalp as we don't know which one is the real PP405? Or would you trial each one individually (say 4-8 weeks) and see what sort of results are achieved this way? ?
neutral
1
u/Sharp-Huckleberry862
You used ODEs wow very impressive
positive
1
u/Sufficient-Mall-4210
how did you guys order from Everychem? my debit cards don't seem to be accepted and I tried a few ?
negative
1
u/steve228uk
What dose are people taking? ?
negative
1
u/Sea-Adhesiveness-928
Any issue with ordering from everychem at the moment? Keep getting some error code that it doesn’t let me give my card details to make a payment? ?
negative
1
u/tribemember321
Is there a tldr for negative side effects? Or is the worst thing that can happen is it doesn’t work (3HP) ?
negative
1
u/Tasty_Bite_1973
I've ordered 8 bottles of 3HP. I'd love to know the exact dosage that people are currently using daily. Anyone here have that info? ?
neutral
1
u/Abel_091
this is really cool and impressive but is it like a replacement for antiandrogen?
meaning I get its a different mechanism but it seems best ways to treat hairloss (of what available) a) growth stimulant b) antiandrogen
does this compound suggest no longer needing either if it works?
100% down to order I use a topical Finasteride.
Does this need to be mixed or comes fully ready? ?
yes, i am so sick of the FDA waging war on sunshine!
151
u/HamHockShortDock
What is their obsession with ivermectin and hydroxychloroquine?? How is this making them money?
87
u/Virginia_Hall
I have not yet found my favorite psychedelics on Amazon.
43
u/Vkardash
First off. He's the head of HHS and not the FDA. Does he have influence? Yes. But the FDA has its own commissioner, regulatory process, and Congressional oversight. And none of this shit he said ended up being true. Surprise to no one. The FDA still regulates everything he mentions in that tweet. Raw milk is still illegal in most states. No sweeping reform in psychedelics. Stem cell clinics are still highly regulated. None of these systems disappeared.
It honestly sounds like he's just making stuff up. "War on vitamins"??? You can buy vitamins literally anywhere. 😂
42
u/itswtfeverb
Marijuana? ........Oh, I forgot the alcohol industry paid to nix it
25
u/Ashamed-Status-9668
In 2025 he laid off 3500 folks in the FDA and in total about 10,000 folks in the U.S. Department of Health and Human Services (HHS) which includes the FDA.
22
u/Optimal-Hunt-3269
Don't forget high colonics!
13
u/vonbehren
[deleted]
12
u/sirsadalot
He did absolutely nothing. Similar to how Trump did the opposite of everything he promised. TL;DR? Nothing ever happens.
10
u/pdubly
Perhaps a better way to ask this question would be to decompose what he’s saying, and attempt to find evidence of any progress. Then perhaps extrapolate out…
I feel many in this sub are missing the point, and being overly political. He is a political appointee, and probably misspoke somewhat. Disclaimer: I’m no cult member. :)
To be fair, “supplements” are typically all thrown into one bucket by mainstream science and dismissed out of hand. What is generally said is that supplements are not effective.
The truth is that there isn’t robust evidence to make such blanket statements. Which is to say that the studies haven’t been done which would ‘prove’ whether or not ‘supplements’ are effective in improving health. Not to mention that throwing all supplements into one bucket and making generalizations is completely disingenuous.
Nonetheless, there is research on some specific supplements that show they either do or do not have an effect on human health in specific contexts. One off the top of my head is creatine.
My point is that ‘supplements’ are typically dismissed out of hand by mainstream health professionals and scientists, many of which never learned about the topic in medical school and do not have studies that would to point to their conclusions in a meaningful way. Their statements are then typically interpreted (or explicitly said) as ‘they don’t work’, whereas the truth is that broadly there isn’t enough scientific research nor studies to say conclusively either way.
So, if mainstream science is dismissive without evidence (ironic), they are lending credibility to that argument, while the truth is there isn’t enough data, evidence, science, research to make that conclusion. Essentially, they are stigmatizing the topic, which can have negative downstream effects of creating a general lack of interest in a topic that could in fact lead to positive outcomes from research into these substances, which happen to be largely unpatentable.
“FDA’s war on sunshine” sounds absurd, but there is concern that sunscreen could block the bodies ability to create vitamin D. There is at least one study looking at this specifically. I don’t recall the results or robustness of the findings. You’re welcome to look that up on the NIH website. Anecdotally there is also some research out of Australia that looks at sunscreen usage rates and skin cancer rates over time (correlation does not equal causation). Again, you can go look that up yourself, the science is real. It is established that a majority of people in the U.S. have low levels of vitamin D, do not get enough in their diets, and it’s a health concern.
Regarding peptides… There are recent changes which appear to be paving the way towards better standards and regulations to make peptides safer for end users by limiting fly by night sources, improving oversight of compounding pharmacies, and not penalizing doctors and end users. This is happening in realtime. The peptides user community crowdsourced testing of some of the research chem sources, and it’s a bit scary. I’d tentatively call all the above progress.
What about the horsey paste? In the end, there may be some value in ivermectin use with covid, perhaps simply via some anti-inflammatory mechanism. I’m not an ideologue on this issue either way. I think being open minded and doing the science is the right path. We don’t have conclusive science (only clinical evidence) on whether it helps or not, and to what degree it is helpful or harmful. Again, it’s been politicized on both sides, and as a result we either miss the potential benefits or risk the potential harms. Who does benefit from the fighting and lack of science? It’s a fair question, but probably not for this sub.
I’m not defending anyone here, just humbly attempting to make a more nuanced point that people tend to jump to conclusions without evidence, and in a sort of scientific-ish r/ where we’re sorta fringe anyway, we ought to be taking a more scientific and objective look at stuff like this. It’s not doing ourselves or anyone else any favors to continue to contribute to misunderstanding by politicizing topics and derailing objective science.
10
u/OrganicBrilliant7995
Regardless of whether you like RFK, the FDA is and has been the greatest obstacle to health progress.
This is what most voters want, though. They'd rather have safety over reward and the risk that comes with it. If we have to have a few corrupt officials paid off by pharmaceutical companies, so be it.
7
u/Cautious-Ad-9554
If you want this to come true you have to support unions and establish a more realistic life/work balance for American workers. You also have try and do things like have employer based insurance refund gym memberships if you go. This admin is very anti worker. RFK’s goals are unattainable for the masses bc of who he works for.
6
u/xiovelrach
RFK is functionally braindead and has setback public health decades.
6
u/irlostrich
If we’re being charitable, then maybe we could say his attitude contributed to the buzz we see about grey market peptide usage (eg the “chinese peptides” craze on twitter). I personally think this would have happened in any timeline with ozempic though.
And I’m tempted to say that the state of affairs for the nootropics demographic in general has actually gotten worse during this administration due to tariffs making it harder for us to import from india and china.
5
u/Full-Shelter-7191
It’s based of anti-scientific rhetoric and the false premise that somehow the FDA is trying to surpress your access sunshine, vitamins and exercise
5
u/painalpeggy
Are people healthier yet?
5
u/Ok_Refrigerator9461
We’re all going to die.
4
u/Misterallrounder
RFK is against nature..he is trying to ban Kratom yet here he is saying that he is FOR nature...it's sickening
3
u/Noblez17
I'm Down for psychedelics at least 🤷🤷♂️
3
u/Jwbst32
Glyphosate for all !!! 😂😂😂
3
u/Actual_Musician_4157
Lmao nothing changed
3
u/nonlinear_nyc
We got… roundup in our food supply.
3
u/[deleted]
Funny that the Trump admin is taking all that pharma money and they’re making record profits, again
3
u/Automatic_Opposite17
Says the heroin addict, coke-head brainworm guy.
3
u/LessMention7652
Why did he forget methylene blue and MMS?
2
u/SoggyGrayDuck
Likes peptides but against 7oh. Someone just needs to get him to sit down with the 7oh hope alliance. He should understand the benefit. I think he was one that used benzos or liberum from a doctor for several years after stopping street drug use. It's something you'll see is actually quite common in older AA stories. It's like a 5 year period of something you can use to take the edge off but won't destroy your life at the same time (historically controlled by the number of pills in prescription) if you mess up and have a bad day.
2
u/No_Opportunity1934
Bro hasn’t even gotten red40 off of shelves though?
2
u/popcorn-trivia
Hasn’t come true for peptides. I think more and more sites get shutdown (b/c semaglutide peptide cuts into Ozempic profit, etc).
2
u/BGMilan
Here come the reddit scientists
2
u/No_One_1617
For the rich it has always been true
2
u/SillySpoof
Good thing FDA stopped suppressing sunshine and exercise.
/s
2
u/Inevitable-Cherry598
But we're using toxic pesticides proven to cause cancer because Trump loves Monsanto.
2
u/xbt_
The peptide part somewhat improved very recently, a list of them recently got approved to be compounded in the US. Not sure about any of the rest.
1
u/Traditional_Air_6867
“Post Meridiem”?
Woah, dudes really accessing 100% power here…
1
u/cs_legend_93
Make dmt legal 100% and then I'll believe you.
1
u/surstrommingsex
New foundation of RC scene since NL ban? 🥲🤣🤣
1
u/SamPDoug
What a good-looking question!
Lol, no. And based on what I’ve heard from RFK jr lately, what little change there will be is going to be very slow.
1
u/Leading_Matter_1168
Oh thank god! I’m so ready for the drugs
1
u/hoteppeter
It’s in progress
1
u/IncandescentSplash
As someone who has benefited enormously from psychedelics, I hate seeing the thing that helped me become associated with this completely unqualified Trump grifter and named in the same sentence as ivermectin and hydroxychloroquine.
1
u/michaelmhughes
Well, the moron is responsible for the rise in measles, for one. He’s a dangerous lunatic whose face looks like an old shoe.
1
u/Ok-Parfait-9856
No, the current administration has shut down peptide vendors. They do the opposite of everything they say.
1
u/Conscious-Comment-66
Sunshine and milk came true!
1
u/ScaryLetterhead8094
But also the hemp bill is making CBD much less accessible. Right? So what’s up
1
u/Olga2757
He forgot snorting off of toilet seats.
1
u/ketchupisfruitjam
he had me at the first half I'm not going to lie. broke clock is right twice a day
1
u/Drbilluptown
He has such vast medical knowledge. /s
1
u/fleetze
I love how he's mixing in the BS like. Sunshine, bloodletting, exercise, flat earthery, get good sleep, drink mercury.
1
u/SCHawkTakeFlight
Not yet, hoping we dont go back to non evidence based medicine. Don't have to prove a therapy works before consumers spend money on it or at a minimum won't hurt you.
Also, at one point I am betting ivermectin, hydroxychloriquine and hyperbaric devices were patented...thats generally how new innovative tech works. It gets patented to secure profit for x time. After x time anyone can make it. Otherwise, there is disincentive to make anything new if someone can copy it right away and sell it cheaper because they dont have to recoup all that development cost.
1
u/DizzyMeatball1791
It’s crazy that a man in recovery wants to promote psychedelics.
Ultimately, this work has demonstrated an improved protocol for generating all major hippocampal subtypes from hPSCs. Not only does this approach generate the longelusive CA1 subtype that has been missing from previous protocols, but the method is able to produce region-specific astrocytes. The rich electrophysiological properties of the neural cultures were found to be sensitive to morphology (monolayer vs organoid) and astrocyte to neuron ratio. While significant work remains to elucidate the complex workings of the hippocampus, the individual cell types, and understand inter-region interactions, the ability to culture a more diverse array of neural subtypes will be an invaluable tool for future research.