Channel: Foundation Fighting Blindness clear
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| 1 | Foundation Fighting Blindness | Induced Pluripotent Stem Cells (iPSCs) Explained | 1247 | 22 | 54.5 | 2:04 | Induced pluripotent stem cells, or IPSCs, are cells that can become almost any type of cell in the body. Research and clinical trials are using IPSCs to study and potentially treat retinal degenerative diseases, including retinitis pigmentosa, usher syndrome, cone rod distrophies, and age-related macular degeneration. IPSCs are typically derived from skin or blood cells from healthy adult donors, or in some cases from affected patients. The skin or blood cells are then modified and allowed to become IPSCs. The IPSCs are a blank canvas and can be made into nearly any type of cell. IPSCs can be used for research or converted to other cell types to potentially treat disease. IPSCs are used in research to gain a better understanding of the causes of retinal diseases. Some researchers use IPSCs to generate retinas grown in a dish, which are known as retinal organoids. Researchers are using retinal organoids to study causes of retinal disease and to assess potential therapies. Cell therapies for retinal diseases use IPSCs that are converted into the cell types that are lost in disease, including photoreceptors and retinal pigment epithelial cells. IPSCs are also being used to create cell therapies. Cell therapy involves replacing cells that are lost or damaged due to disease with new healthy cells to restore function. When IPSCs are made from the cells of another person, it is often necessary for the cell therapy recipient to take specific medicines, called immunosuppressants to keep their body from rejecting the new cells. Cell therapy clinical trials are currently underway for retinal diseases, including retinitis pigmentosa, usher syndrome, cone rod distrophies, and age-related macular degeneration. To learn more and get involved, visit fightingblindness.org or scan the QR code. This video is presented by Blue Rock Therapeutics. | ↗ |