Channel: Investigate Explore Discover clear
| # | Channel | Title | Views | Likes | Cmts | Score | Sentiment | Duration | Transcript | Link |
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| 1 | Investigate Explore Discover | Unraveling Cellular Reprogramming: Insights into Lineage Conversion wi... | 272 | 12 | 57.3 | 0:57 | Direct lineage conversion, a process that transforms cell identity through transcription factor over expression relies on the reconfiguration of gene regulatory networks, GRNs. To shed light on this complex process, scientists have combined computational analysis and experimental lineage tracing. Using cell oracle, a computational method that infers GRNs from single cell transcriptome and epigenome data, they simulated gene expression changes in response to transcription factor perturbation. Linking early network states to reprogramming outcomes in fibroblasts, to induced endoderm progenitor conversion, they identified distinct network configurations associated with successful and failed fate conversion. Through in-silico simulations, they uncovered the involvement of new factors, including the AP1 subunit boss and the hippo signaling effector YAP1, in driving successful cell identity conversions. This study showcases the power of cell oracle in inferring and interpreting cell specific GRN configurations, providing valuable mechanistic insights into lineage reprogramming. | ↗ |