Channel: Mayo Clinic clear
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| 1 | Mayo Clinic | Regenerative Medicine: Making the Impossible Possible | 7653 | 91 | 53.1 | 2:30 | The heart muscle cells that Dr. Tim Nelson views highlight recent advances into regenerative medicine. The simplest way to explain that is it's the opposite of degeneration. Tissues in your heart, joints and other areas can degenerate or break down with time or disease. The regeneration is the renewal of those tissues, which is something the body does naturally. So one strategy is to try to find ways to improve the healing of your body. And another strategy is to actually supplement or augment the stem cells in your body so that we can improve the healing by transplanting stem cells into it. Dr. Nelson and his colleague Dr. Andre Terzin used stem cells in their research because stem cells are responsible for growing new tissue. So stem cells just means that they're seeds that can grow into many, many tissues. Stem cells can come from a variety of places, embryos which are not generally used anymore, umbilical cord blood, adult blood or adult bone marrow. So the type of stem cell will dictate how many different types of tissues can emerge out of it. Scientists can engineer stem cells into the type of cells they want. Here's how it works. Cells called fibroblasts are removed from a patient's skin. They're reprogrammed into what are called pluripotent stem cells. Those cells can be taught to become any type of healthy cells, such as these heart muscle cells. The idea is that the newly engineered healthy cells, when introduced to say those of failing heart, will help restore or regenerate the function of the unhealthy cell. This is one cell that's contracting, is working with many cells and that gives the whole tissue the contraction pattern like a normal heart. It becomes much more real when you have a personal connection to a disease or an illness where we don't currently have good options. And this is where people are asking more and more of the questions, what about stem cells? The answer is researchers, such as these at Mayo Clinic, push forward to make regenerative medicine a reality for patients searching for successful treatment and perhaps cures. For Mayo Clinic News Network, I'm Vivian Williams. | ↗ | ||
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| 2 | Mayo Clinic | Mayo Clinic Study Shows Induced Pluripotent Stem Cells Repair Heart | 3806 | 11 | 47.6 | 1:44 | This technology has been used in proof of principal concepts for other diseases such as Parkinson's and sickle selenemia. But this is the first study that has demonstrated that these cells have the unique capacity to repair and regenerate the heart after a mild cartiline fraction, where there is severe damage to multiple liniages throughout the heart. IPS cells have a unique ability and that they can recapitulate the unique features of embryonic stem cells that being said they are able to give rise to literally all tissues of the developing embryo and adult body. This feature has previously been only possible with embryonic stem cells and now with this technology we can recapitulate that ability using ordinary cells to start with and reprogram them back to their embryological origin. The word is pluripotent autologous stem cells. That means that these cells have all the potential of embryonic tissue or embryonic stem cells but they are derived or they come from your own body so they are autologous. This is a unique ability that isn't possible with any other cell type and what it allows us to envision and allows us to do today in experimental studies is to use the cell from an adult, create the stem cell and transplant that back into the same individual. This allows the body to recognize that it is self tissue and not rejected as foreign tissue. | ↗ | ||
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| 3 | Mayo Clinic | Innovation to Impact: Regenerative Medicine for Consumers | 3541 | 7 | 47.1 | 2:31 | I think what constantly motivates me as well as my colleagues is just is the patience. And so we went into medicine to help people. We're really motivated to come up with new treatment options for people. What excites me about these orthobiologic options we have is that it opens up new options for patients. For patients with musculoskeletal pain who either are not candidates or are not interested in surgery, Mayo Clinic Sports Medicine has a few unique options. Some of those unique options are injections such as orthobiologics. The huge benefit is avoiding surgery. By doing that, you're avoiding complications from a surgery, whether that's anesthesia-related complications, but also avoiding larger incisions, which oftentimes requires a longer post-op recovery. And so because we're using a smaller incision, there's usually less recovery involved. Mayo Clinic is one of the leaders in providing orthobiologic injections to individuals. And it's not that we're inventing new substances to inject, but what we're doing is taking a look at the composition of these substances, taking a look at the outcomes of individuals after these types of injections. The safety of these injections is definitely a priority at Mayo Clinic. We are only doing procedures and injections that comply with the FDA regulations. And that's for the purpose of patient safety. We're evidence-based in what we're doing. There's a lot of hype about these different injections. There's a lot of hype about these different procedures, but we're guiding what we do and guiding what we're looking into based on the evidence, based on the science. That's really unique about Mayo Clinic. I love having that ability to say to someone, we have something else to offer. We can consider this. It's encouraging to patients, it's encouraging to me because I want to see them improve. That's what's most exciting about these injections for me. | ↗ | ||
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| 4 | Mayo Clinic | 3D Bioprinted Skin: Breakthroughs in Regenerative Medicine | Tomorrow'... | 2127 | 34 | 36.4 | 39:34 | No transcript | ↗ |