Amazing dig of troves you present, which had to have taken weeks (months?) to correlate.
Thank you, OP. Please consider x-posting to r/LivingWithAlzheimers for the value it will bring to others, as this new sub explores ways of supporting we who are living with Alzheimer’s.
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u/headgoboomboom
As a neurologist, I find this quite impressive. I have a strong family history and 1 copy of E4. I have been trying to develop a regimen involving repurposed medications. However, that protocol involves more risks than your's.
Here is an AI summary of my latest multidrug regimen proposal.
https://www.perplexity.ai/search/analyze-this-combination-regim-RV8xmKCvSzyAXIojV4Qq1g
8
u/whenbirdsswim
Thanks so much for posting your research. Curious what you think of Bredesen, you don’t list much about diet?
2
u/RedDlish
I would get my father alternate MCT oil and ketone supplements. And they had some positive effects for my father.
Really interesting. The fact that there is a significant portion of the population that just needs less sleep, and are otherwise completely fine, indicates that there might be a magic bullet that just reduces sleep need without negative side effects. Maybe it’s GHB or a related compound.
I’ve heard of it and that there’s potential for abuse with. I don’t know much else so would be curious to know more about the anecdotal reports.
I’m of the opinion that Orexin, or some other closely related protein that’s produced in excess by people with the genes for Short Sleeper Syndrome is a really promising candidate for this.
Caffeine of course just works, but it’s mostly a tool to control “when you’re tired” rather than “how much you’re tired.”
I find modafinil is useful when traveling between time zones and I need to make a 4 hour sleep day just work. Sometimes it’s useful if there’s a massive time crunch with work, but that’s not often applicable to me. I’m skeptical of repeated long term use to cut hours from a regular sleep schedule without negative side effects.
Otherwise not much has worked for me besides good sleep hygiene. Wake up early and consistently to red light, cool room, good mattress, 8Sleep of money isn’t a big concern, sleep mask, Ozlo Sleep buds and full 8 hours.
9
u/eyeap
I'd be willing to try it out after it goes through 2 year rat tox and carc studies.
6
u/MC_Cuff_Lnx
This is very interesting, but can you elaborate on antipsychotics for sleep enhancement? I know someone who takes one and I would love to be more informed on your perspective.
3
u/LateNightMoo
Can you tell me more about why antipsychotics are worse than bad for sleep? I was on some several years ago for treatment resistant insomnia and I feel like I still have sode effects from them today
2
u/march7984
In the 90's I was obsessed with a supplement called "renewtrent" which was GBL, I would sleep for 5 hours and wake up feeling phenomenal. It was amazing and then the FDA banned it.