I did FOX04-DRI about two months ago. I'm on the road and will share full tonight. My optimal dose was 1mg on equal sides of the body in the morning (2mg total dose). Day1- leg shots, day 2' belly shots, day 3 -arm shots, day 4 - fatty neck shot and day 5 - back to belly. Idea is to physically spread it around. The first two or three doses I could feel spreading in my body by a weird tingle, after that nothing. I do think it stayed in my body for about a week, mentioning because half life is unknown. Only negative side effect was lethargy for the first four days
Would I do it again? Probably, I "felt" a youthful vibrancy for about a month after. Eyesight was sharper. Hair filled in some along with less gray (I cut my hair short). Now, two months out, nothing. I'm tempted to do it again, only hold back is cost at $265 / 10mg vial). Also, would only recommend to people over 45.
neutral
3
u/kellytownsfinest
I read all of that and maybe I’m too dumb to understand, but what is the benefit of said protocol? Like why is it important to get rid of senescent cells? ?
neutral
2
u/walt6076
I've done FOX04-DRI, I'll say it's painful. I limit it to 2.5mg a dose and only once a week. The injection spot remains sore for almost a week. I'm not sure how people tolerate those higher doses. Plus it only comes in 10mg vials so you're going to use multiple vials for just one injection.
negative
1
u/IndependenceVivid384
There is not just one study. In fact, there is another study that claimed FOXO4-DRI use in mice and rats with pulmonary hypertension made them worse. Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression" (Born et al., Circulation, 2023)
*edit: also like to add that Fisetin, and Gingerenone A and 6-shogaol (from ginger) are senolytics as well. I'm actually not sure about Quercetin anymore either, but yea, that one too.
negative
1
u/Responsible_Path2557
What are your thoughts on SS-31 in this protocol? - Specifically, if it needs to be stopped prior to beginning fox 04-dri, how many days prior? And when can it be restarted afterward? I’ve seen where some researchers have run SS-31 simultaneously with fox 04-dri, but wanted to hear your thoughts if you have any to share. Thanks in advance. ?