The single-injection simplicity is what makes this a genuine breakthrough. Inner ear surgery has historically been invasive, but delivering AAV through the round window membrane without drilling is a game-changer for accessibility. The age range proving effective across infants to adults closes the biggest remaining gap in genetic deafness treatment. Otovia’s involvement means commercialization is already underway, so watch for U.S. and EU trials in the next 12-18 months.
positive
19
u/No-Examination-96
They didn't include the elderly in the study. I Wonder if it will be effective in them. My dad sure could use it.
negative
2
u/sunny_6305
I have a feeling that the answer is probably no but can it fix audio processing disorder? ?
negative
1
u/Gl5omtyx
The fact that it works across age groups is what makes this genuinely huge
positive
1
u/1erRPIMA-fiesta
Sensorion (France) is working exactly on the same method, if I recall
neutral
1
u/kngpwnage
Study here: http://dx.doi.org/10.1038/s41591-025-03773-w
neutral
1
u/blurredorbit
The round window membrane delivery is genuinely elegant from a surgical standpoint
positive
1
u/Candid_Koala_3602
Why haven’t we just bypassed our ears completely with the bone that picks up the vibrations? Don’t they already have headphones that do exactly this? ?
I feel like the various traumas I've been through have shaved years off my body. I used to be able to endure a lot physically, and now I have chronic pain and I get tired a lot quicker than I used to. I'm in my early 30s now but this doesn't feel like just normal aging.
negative
184
u/SoberShiv
The reason is it’s because it’s fairly new (in terms of biopsychological research). Also the DSM threw the neuroscientific Research out in the 80s bc yoga etc doesn’t make Big Pharma any $$$$. Keep labelling ppl as ‘disordered’ = hand out more drugs = more $$$. Mind/body connection has been around for centuries. You can’t think away your trauma - it lives in the fascia
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u/EvilNassu
I've been lately wondering if chronic stress affects the adrenal glands, since they're constantly pumping out cortisol and working overtime which maybe could in turn cause insulin resistance and adrenal PCOS, would explain my symptoms really well.
neutral
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u/ladyhaly
Your research is solid, and if anything you've understated it. The 2-7 years figure comes from some of the more conservative estimates. Simon et al. found telomere shortening equivalent to as much as 10 years of accelerated aging in people with chronic mood disorders, and Wolkowitz et al. found approximately 7 years in those with long-duration depression. One study on specific immune cell subtypes (CD8+ T cells) found telomere shortening equivalent to nearly 28 years of additional aging. The range depends on which cells they're measuring, depression severity, and chronicity, but the overall pattern is consistent and reproducible across dozens of studies at this point.
The concept that ties all your listed mechanisms together is allostatic load - the cumulative wear-and-tear on the body from chronic stress activation, first described by McEwen and Stellar in 1993. Your HPA axis fires cortisol, which drives inflammation (those IL-6 and CRP markers you mentioned), which damages telomeres, which accelerates cellular senescence, which feeds back into more inflammation. Self-reinforcing loop. Sleep disruption sits right in the middle of it because sleep onset normally inhibits cortisol secretion. When that's disrupted, the HPA axis stays activated and the whole cycle intensifies.
To answer your actual question - yes, absolutely bidirectional. I work in healthcare and have my own CPTSD recovery behind me, and the thing that surprised me most was how much improving sleep and consistent low-level movement (not exercise goals, just walking regularly) shifted my emotional baseline in ways that years of just talk therapy hadn't. Not because therapy wasn't working... it was. But I was trying to rewire my brain while my body was still running the stress programme 24/7. Once I sorted the physical side, the therapeutic work became a bit easier. Like the soil had to be ready for the seeds to take.
As therapy helped me understand my triggers and reduce the frequency of emotional flooding, my sleep improved without me specifically targeting it. The research on allostatic load suggests inflammation markers respond to both directions: exercise reduces inflammatory biomarkers directly, and reducing psychological stress exposure reduces the chronic HPA activation that drives inflammation in the first place.
You've nailed the frustration about the gap. There's a real structural problem where trauma clinicians aren't trained in metabolic health and GPs/endocrinologists aren't trained in trauma-informed care, so the patient ends up being the one who has to bridge the two worlds. Shouldn't be that way, but knowing it IS that way means you can advocate for yourself more effectively.
One thing worth being precise about for anyone reading - the somatic component of trauma is real and well-documented, but it operates through the autonomic nervous system, the HPA axis, and interoceptive pathways. Not through fascia or other tissue-level "storage". That's not supported in peer-reviewed research. Van der Kolk's original work on the body holding trauma describes nervous system patterns and biological stress responses, not connective tissue. The science is impressive enough on its own terms without needing to reach for mechanisms that haven't been demonstrated.
If you want to dig into the research yourself:
McEwen & Stellar (1993) - Allostatic load model: cumulative wear-and-tear from chronic stress
Van der Kolk (1994) - Trauma encoded via biological stress response and nervous system patterns
Simon et al. (2006) - Telomere shortening in mood disorders, up to 10 years of accelerated aging
Balbo et al. (2010) - Sleep disruption and HPA axis activation
Wolkowitz et al. (2011) - Telomere shortening proportional to lifetime depression exposure, ~7 years accelerated aging; correlated with inflammation (IL-6) and oxidative stress
Karabatsiakis et al. (2014) - Telomere shortening in specific immune cell populations (~28 year differential in CD8+ T cells)
Vakonaki et al. (2018) - Review of telomere length and common mental disorders
Mendes-Silva et al. (2021) - Late-life depression and telomere shortening as severity marker
Ismail et al. (2025) - Meta-analysis on depression and telomere length
Au Young et al. (2025) - Systematic review of telomere length and telomerase activity in MDD
positive
39
u/No_Title38
I’m attending an online talk tonight titled ‘The Neuroscience of Adverse Childhood Experiences’ - will be interesting!
I agree, the whole of healthcare would actually help if clinicians took a holistic approach. I aim for this myself (mind, body and spirit).
neutral
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u/QuietExact2734
Yeah a lot of my life improvements have been built around 'the body'. Once I got 'clean' 38 years ago I began a deep dive into healing most of which revolved around physicality and spirituality, ( also fell into periods of spiritual bypassing, sigh).
(I had deep distrust of all authority, so avoided any and all dealings with mainstream 'health' involved bodies/ authorities, amongst others. To the extent that at times when I though I could die due to one thing or another, well so be it, I ain't going near those fuckers! Amazingly enough I'm still here. Also, no interest or willingness to drug myself, legally or illegally, for me, one of my best moves, I believe)
Once I had stabilised enough, which took 3 years or so, via NA, I took up a martial art 'full time' for 4 years, and I mean 24/7. I then began healing with an 'eastern medicine' practitioner 2 days a week for 3 years - amazing, powerful and at times hard to believe. Worked part time to support it (he gave us great rates - he knew the depth of what we were dealing with, which was more than we did at the time, haha). All the while dealing with what we have to deal with...
Made a lot of 'relative' progress - I knew I was generally 'out of body', but had no idea back then how dissociated I really was, and how deep the fear/ trauma went. Working with my body in so many different ways over the years helped me bear it all, and also create the conditions for future healing
Relatively stabilised, I married my love, a miracle I believed I would never have the opportunity to do, and moved country again. Raised two children, all the while seeing a chiro and a deep tissue massage therapist fairly regularly (just as well we lived a 'quiet life' as otherwise could never have afforded it).
Oh yeah, had discovered I could not work with or around people directly much, and being inside did not work for me either. So worked outside in nature, in the countryside doing a physical job, which really worked for me.
Had a bit of a breakdown after a combination of the brutal suicide of a very long time friend (even if we had not seen each other in years - there were still ties that bound us), allied to a betrayal by my employer which left me and my wife and kids in a bit of a fix.
Took time out and my wife returned to work. After about 18 months went back to work part time, again outdoors and physical - helps in so many ways, not least burning off stress and associated hormones etc, being 'on the move', forestalling feeling 'trapped' in one place etc. Have been working part time for the last 20 years - I accepted I need a lot of down/ processing time and worked with it. Once I got over the 'shoulds' etc etc.
Ongoing bodywork with holistic chiro, Bowen therapist and others at different times, eventually my earliest traumas began to emerge primarily somatically (mostly pre verbal trauma by this stage) and seek attention. Also had an epiphany about 5 years ago, which lead to 'discovery' of the realities of complex trauma etc, which was so illuminating and such a relief actually - explained so much. Even saw a therapist for a while!
More recent epiphany re stress etc and 'internal' tension negative feedback loop, through one thing and another. A few months ago began working with a pelvic health physio which is like a magic piece of the jigsaw puzzle. And which has me finally really coming into my body - challenging and scary, but my capacity is expanding in so many ways.
Anyway probs far too long. But between long term dissociation and a body/ physical health orientated life, including good healthy food and lots of water over nearly the last 40 years, I look a lot younger than I am, so theres that ...
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28
u/Sexy-Dumbledore
I havent slept more than 3 hours a night in about 5 years. I'm 33 but atp I feel like I'm in my 80's. My 70 year old MIL has more energy than me
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26
u/batman_6699
Myself a trauma survivor, recovery is also very difficult. India has a very poor mental health system. My therapist is giving me medications and counselling. There is no EMDR therapy, somatic experiencing therapy which heals the trauma faster. People in United States have all these facilities.
negative
17
u/-Shinama-
Gut microbiome does so so much more with your body in general than you would think. The amount of research on this topic has spiked in recent years and damn, we're fucked
negative
15
u/Emergency_Wallaby641
oh yes, the more at peace I feel, I sleep better, my skin is more vibrant, energy is better, food tastes better...
What I observe, when someone is stressing a lot they seem to get grey hair sooner, also potential stomach issues.... Someone who got unprocessed anger, could be issues with liver.. We are living organism, sometimes we forget that.
Another issue is all the consumption of media dont provide any peace for the body at all, only more suffering and tension, most stuff we consume from the online world that just wants our attention to monetize it.. So that provides even more health issues, because we are dissociating for consumption, and we dont feel our body anymore and we are not aware if something is "off" to resolve it sooner so it doesnt escalate further
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14
u/According-Ad742
Doing all those interventions and have to share that eating anti inflammatory foods, which came to an extreme about a year ago bc as it seems my mast cells react to anything that could upset them… my theory is that this is due to system overload (sensitivity) bco cptsd. So now I’m on a real Spartan sort of anti inflammatory diet which has made the gut brain connection so utterly clear and shown a direct correlation to the foods I (shouldn’t) eat -> anxiety and depressive symptoms. To mention one; peanut butter and it’s ever present mold content spirals me in to existential crisis every time it passes my bowels.
I found I can eat many things on the food list at mastcell360.com, tweaked to my individual predisposition I suppose. No sugary or starchy foods, no fructose.
It has been a game changer.
Very little about decades of therapy helped. Like I can specifically point to what helped; group therapy settings unveiling my own story by seing myself through relating, or having a therapist expand my vocabulary with the word “validation”… I figure therapy was mostly intellectualising and that in itself is a trauma response that kind of resists processing feelings by conceptualising. Ego (thinking) is survival trying to keep the body safe, not functional to be stuck in. Feelings and thoughts are like on different operating systems. Psychiatry doesn’t really practise validation does it, and I find, David Bedricks work on shame and what we are really looking for when we share our trauma, really interesting. We want a witness, my interpretation; that makes us trust and validate our own perception and experience so we can process and move on. Anyone that listens to our story and bypasses it by fixing, relating to themselves or downright downplaying us will create shame instead. It will be retraumatising (to hang around tge “wrong” crowd). So that’s where I think peer support far exceeds general psychiatry bc they don’t validate, they label - a “problem”… when there is no problem, there is nothing wrong, but pain asking to be seen and acknowledged, validated for what it is. It’s a natural occurrence asking to be, as is.
I almost didn’t continue reading after the first paragraph of this post, bummed out. But was happy to see that I have ended up practising all of those things reversing the damage.
One of the things I continuously think about is logging on to various social media and completely handing my focus over to the trauma algorithm. I have stopped indulging in so much educational YouTube content on all the trauma related things interesting to me. It feeds a pattern I want to brake, so I keep asking myself what would serve my well being. At some point in this healing journey engaging with content that keeps us intellectualising our trauma and completely overrides our ability to focus on what we really need in the moment will sabotage our capacity to move on… it’s an important step to acknowledge I think. When we are ready to disengage with trauma content. Note that there is zero judgement in me saying that, few places are so validating as this here, seing and acknowledging we are not alone.
Thanks for posting <3
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u/AlexiusPantalaimonII
I keep being told I have to be okay with myself before I can connect to anyone else. But you say social connection here… this is too confusing. Even my therapist said I have to be okay with being alone.
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11
u/[deleted]
I developed irreversible misophonia and IBS after a prolonged trauma-related stress so inflammation at a nervous and cellular level can wreck your body to unknowable extents
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9
u/Obvious-Explorer-195
Oh wow I’m screwed then. Cancer treatment apparently took 20-30 years off my life. Not the cancer itself, but the treatment. Add your findings then that means I’m already 80 years old, though my body could have told me that lol
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8
u/totalpunisher0
Am considered "in remission" as I haven't had serious attempts or ideation in 10 years, and more or less can make it through life without long periods of unemployment or hospitalisation (so far!) I attribute this directly to the physical and lifestyle changes I made, as I did every other type of therapy and medication for 10 years before this. It's really not easy, it easily takes up 90% of my brain space and free time every day, it's a commitment like no other. I often feel resentful that I have to put so much time, energy and money into every single day and choice and action. It's exhausting but also, most of the time I am happy, it's just low periods where I remember how much effort I have already spent on saving my own life today and it's only midday, and no one else "seemingly" has to do the same... And people/friends/family don't really understand "No, I have to go to the gym/do tai chi/stick to my routine RIGHT NOW" so it does cause rifts and I find that hard to explain still.
Having said all of that, I still think I am going to die early due to trauma. It's still impacted me heavily for 25 years of life and still in my bones
positive
4
u/socksmum1
I’ve gone from minimal grey hairs to 80% grey hair from a trauma response( I would assume)
I have a background in CAR-T having worked at the pioneering science of it and a strong background in immunology.
I'm also on Kesimpta which fully depletes my CD-20/CD-19 B cells.
This is not a cure.
I repeat, this is not a cure.
If you take Ocrevus and Kesimpta right now, it does exactly the same thing.
They deplete your CD-20/CD-19 B cells to zero, which is really helpful, but there is still progression with B-cell depleters, albeit less so; that's why we call them DMT's and not cures.
So again, not a cure, but a way to give someone one treatment, and never have to worry about treating them again.
It's not as exciting to me because a monthly or bi-annual shot is already pretty easy to do.
Lemtrada(alemtuzumab), where it reboots your immune system, but is highly unpredictable, is closer to a cure, but it comes with a lot of risks and that's why it's not a first line treatment.
Edit: CD-20 mature b-cells co-express CD-19.
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u/narniediz
What is this procedure like ? Hospital time ? Can you work ? ?
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1
u/Ryan_MedConsultant
A lot of the confusion around CAR-T comes from people mixing three different things together: what sounds promising in headlines, what is actually in trials, and what is ready for real-world use. For MS, those are not the same conversation. The smartest move is usually to pin down trial status, eligibility, and what outcome people are actually measuring, because “hopeful” and “available” can be very far apart. I work with international case planning, and this kind of situation usually gets clearer once someone lays out the treatment landscape in plain English. Has your neurologist told you whether they’re talking about a real nearby trial, or just a future possibility?
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u/Reapo43
It is great to hear that your own neurologist is so much on the cutting edge of MS research for you.
Also, i was offered the possibility to be the 6th patient to ever recieve this treatment which is less severe than my current therapy, sadly i had to decline based on personal reasons and a fear of the side effects, which include cancer and other immune diseases.
It just seems unexplainable to me that we do not yet know the origin of the disease or why it is more pervasive in the north-westen areas of the globe and australia, etc. but yet we are curing it (if it succeeds).
I have shoulder arthritis and this would be amazing if this became reality. Chronic pain is almost unbearable and my only option at the moment is surgery.
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u/jedaffra
Spinal disc regeneration??? ?
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3
u/Vathrik
These treatments are amazing from what I hear but they’re like 22k for an injection set. But the guy who had it done said he went from daily joint pain to playing basketball like he was 22 again. Dunno how long the benefits last.
positive
2
u/AP_in_Indy
As someone who has a pinky-sized hole in their septum, this stuff can't come soon enough.
positive
1
u/2Autistic4DaJoke
These are cool the people is these are all custom therapies which makes it impossible to mass produce and reduce cost.
This is currently something that can only be done in a clinical trial involving immunosuppression agents. Receiving islet transplant without immunosuppression is pointless.
Historically, the immune suppression regimen required to keep transplanted islet cells functional is more risky than having Type I diabetes itself. However, if you require the immune suppression because you're receiving a kidney transplant anyway, then it makes sense.
Currently Eledon Pharmaceuticals is running a phase I trial of tegoprubart - an narrow targeted immune suppression med. The islet cell transplants definitely work very well and the drug appears to be working at keeping them functional at the one year mark.
BUT, the reason why they require multi-phase trials is to prove the safety of the drug. Will it cause excessive infections? Will it blunt vaccine effectiveness? Will it give you a 1 in 1000 risk of lymphoma?
As always, it's going to be a few more years.
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u/Ambitious-Spray-110
It has to be with immunosuppresion otherwise why bother? there is only one clinical study being done on this, Eledon pharma ?
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u/mattshwink
So cost is generally zero in a clinical trial. Immunosuppresants are required.
The Juicebox Podcast has a recent interview with participant number 9 in the study. She was about 1 month in. She has to fly to Chicago every 3 weeks currently for the immunotherapy treatment.
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u/Goddessvienna
I saw a girl on tik tok do it with immunosuppressants given to her the first few days, and then would not require them following the treatment. I think it’s a newer technique they’re doing so that people don’t have to take immunosuppressants.
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u/Elegant_Review_4450
I haven’t personally gone through it, but from what I’ve heard most people who get Islet Cell Transplantation do have to take immunosuppressants, and it’s usually done through research programs or specialized centers. Some people get a few years of much easier control or even time without insulin, but the cost and the meds are big considerations, which is why it’s still not very common yet.
neutral
1
u/Stephen-Stephenson
No, but I'm researching the same topic.
Cure with mild targetted immunosuppression:
Eledon:
https://www.youtube.com/watch?v=ZflOjMW-4MI
https://www.youtube.com/@CrushingT1/videos
I remember listening to a YouTube video and someone mentioned Eledon's cure costing about 35000 USD, but don't quote me on that. This could be wildly inaccurate. They still haven't gone public with the cure.
A scientist on SugarScience said a dose of artificial cells alone for a person cost only 5000 USD. Not a lot. And Chinese are building huge mega-factories right now to mass produces stem cells for cheap. Chinese are supposedly doing really great progress in this regard, but it's yet unclear if their cure will require immunosuppression or not.
Cure without immunosuppression:
Sana said they successfully transplanted 5% of beta cells to a man in Sweden and it worked exceptionally great. The man was very happy, although it did not eliminate his need for insulin (5% is not much, they simply wanted to test their cure). For some reason they don't reveal his name, they haven't done an interview with him and they keep him secret. That sucks and that's weird in the internet era. They are publishing a lot of papers and their cure looks very solid. They are looking for money; sadly, Sana's budget is peanuts. This is absolutely ridiculous. There are billionaires' children suffering from type 1 diabetes and their parents can't finance Sana? Sana's cure looks absolutely awesome, but it looks like they really lack money. Here is their pipeline, https://sana.com/our-pipeline/, the cure is in the pre-clinical state. Not even "Phase 1" yet, although it's past "Research". If I had big money, I would have gotten in touch with them immediately.
Vertex tried and failed last year. I've been listening to their reports and I was baffled to hear that some idiot at their company recommended a really moronic solution for protection of transplanted beta cells. I have no idea why they accepted it, but it sounded really stupid even to me who has no expertise in this field. It sounded like some 13 year old boy writing a new Star Trek episode, some hi tech crystallised grid or something where every cell is put inside of a grid node or something. A total disaster. But Vertex said they will keep trying until they succeed. Their SEO was super adamant about it. No timeline, no promises yet. Doug Melton looked a bit sad in an interview after that (I could read on his face he also was thinking that person who came up with that grid solution was an idiot). He even mentioned something like "I might not be able to see the cure in my lifetime". I could be putting words in his mouth and misrepresenting his point, I need to get back to that interview. But I found it be really pessimistic. I could be wrong. I hope I'm wrong.
A new company started working on the cure super recently, CRISPR. Here is their pipeline: https://crisprtx.com/pipeline. It's in the "Research" phase. Not even pre-clinical. That's sucks, but it's great that they have started working on it. CRISPR are extremely professional and they get things done. A "device approach" is in the Clinical phase is most likely connected to Sernova.
https://crisprmedicinenews.com/news/crispr-edited-beta-cells-avoid-immune-rejection-without-immunosuppressants-in-human-transplantation/
https://www.scientificamerican.com/article/type-1-diabetes-patients-insulin-production-restored-with-new-cell/ - "it’s still too early to consider this approach for a cure" but “There’s tremendous hope.”
A new company has emerged, SymbioCellTech, here was an interview with their SEO: https://www.youtube.com/watch?v=WlnaogIe4HA They are very ambitious. That's all I know.
Not stem cells, but still: an Israeli company hopefully will go public in 2029 with a cure in a form of pills. They promise to stop the immune attack and even possibly regenerate some beta cells. As wild as their claim sounds, they might actually be able to deliver it. They have a very solid background. We tried to contact them by e‑mail and by phone, but we could not reach them. If they responded, we would have gone to Israel already even right now.
https://www.startuphealth.com/startup-health-blog/2023/10/26/levicure-is-developing-a-breakthrough-triple-therapy-for-type-1-diabetes
https://healthtransformer.co/levicure-is-developing-a-breakthrough-triple-therapy-for-type-1-diabetes-b6c521e6b2c5
Diamyd from Sweden is coming public this or latest next year. Their pill stops the immune attack completely, but it works only in some people with specific genes. Mostly girls, for some weird reason, but it's so experimental they themselves don't know for sure what's going to happen. We will try this cure just in case, if they will allow us as soon as they go public. It's safe, so who cares.
Now what we are planning do. We will ask Diamyd to allow them to let our 3.5-year-old daughter try their pill this or next year. They might reject a young child, but we will keep na ?
What I will say is that they have a million anti-emetics that you can take, most often all at the same time. If something isn’t working make it known and they should be able to at least try to help you. If they offer you oral medications vs. IV meds the IV ones work better imo. Best of luck!
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u/osupuck19
I had a similar BV based regimen that my stomach tolerated well. I then had an Autologous Stem Cell transplant and didn’t vomit from that either. The nurses warned me it would actually be loss of control of my bowels that could happen from BEAM and although I definitely had some interesting BMs I never lost control.
Reprogramming T cells does seem very promising.
Using PSMA to guide radiation to cancer cells is also very promising. We need to get it approved for salvage.
My uro believes a lot of men today will avoid metastatic cancer with one or more of these.
positive
3
u/Practical_Orchid_606
There is a phrase in law that goes like this: "Asked and answered." It means that a lawyer can only ask a question once during deposition or oral examination. Using the immune system to fight cancer has already been tried with Provenge with only lukewarm success. Do not be fooled by Dr. Marson's enthusiasm for his project. He is an academic and will be judged by the quality of his research even if it results in a Provenge quality treatment. Academics need to 'sell' their projects for the purpose of attaining money to continue his research.
Mother nature has blessed PCa men with several biological gifts. First, unlike other cancers, PCa is slow growing. It has a built-in warning system with the PSA protein that can be measured. Men have a built-in mechanism to halt PCa growth by lowering testosterone. And finally, PCa cells express a protein called PSMA.
I agree with Special-Steel in highlighting PSMA guided radiation as an area where new therapies will be developed. This technology is now available as Pluvicto which is for late stage advanced cancer that is castrate resistant. I believe in 3-5 years, it will be available at the initial recurrence level. Nowadays, the treatment intensity at the Gleason 7-10 is high due to fear of BCRs. If this fear is diminished due to robust PSMA guided radiation, all men with PCa will benefit.
The detail about monitoring iron flux feels especially useful if labs need a fast quality check before pushing MSC batches forward. If that readout really tracks cartilage potential well, it seems like a practical bridge between stem cell manufacturing and actual repair outcomes.
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u/fchung
Researchers have developed a new method for monitoring iron flux — the movement and rate at which cells take in, store, use and release iron — in stem cells known as mesenchymal stromal cells (MSCs). The system can provide insights within a minute about a cell’s ability to grow cartilage tissue for cartilage repair.
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u/fchung
Reference: Yanmeng Yang, Meiqi Kang, Mengli Chen, Liang Cui, Zheng Yang, Jongyoon Han, Cellular iron flux measurement by micromagnetic resonance relaxometry as a critical quality attribute of mesenchymal stromal cells, Stem Cells Translational Medicine, Volume 15, Issue 2, February 2026, szaf080, https://doi.org/10.1093/stcltm/szaf080
Local therapeutic stem cell injection does not have an effect on lifespan. Injected stem cells are not integrating into you systemic stem cell pool or depleting it. They act locally and transiently.
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u/peglyhubba
Wow that is great to know. I’ve had my own stem cells put into my knees. And my own protein rich platelets also injected intro my non existent cartilage. My knees are so happy. They will live on without me! Haha 😂
positive
2
u/pandit_the_bandit
I have had almost $100,000 of treatment from Regenexx in Cayman Islands and there is ZERO chance it will extend my life. It’s solely to treat orthopedic problems
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2
u/Wanderir
Genetics is first when it comes to longevity, them environment and lifestyle they follow by a wide margin.
I’ve not seen or heard of any evidence for stem cells. Do a search for studies.
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u/raj_uv
Genetics and lifestyle balance is key. Stem cells only increases chances of positive outcomes as everything is subjective to the individual case at hand.
I get stem cell IVs and enough exosomes for anti aging twice a year in Switzerland but I’m overall healthy and no underlying issues or injuries.
In your friends case if she is getting localized injections that’s not enough for longevity imo maybe good enough from injury to recovery and some added benefits but if she’s getting IVs with enough stem cells and exosomes or growth factors then she has increased odds but no guarantees
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2
u/iNap2Much
Can't speak for stem cell therapy, BUT... stem cell TRANSPLANT can save your life. If you need one.
Machine-translated from Japanese:
2026/03/11
Nippon Shinyaku's cell therapy for DMD, CAP-1002, resumes review in the US
Nippon Shinyaku announced on March 11 that the US Food and Drug Administration (FDA) has resumed its review of CAP-1002 (deramiocel), a cell therapy for Duchenne muscular dystrophy (DMD), for which it holds sales rights in Japan and the US. Its partner, Capricor Therapeutics, announced the same on March 10.
Capricor received a Complete Review Letter (CRL) in July 2025 stating that the current application could not be approved. However, the CRL was lifted and the review resumed following subsequent submission of Phase 3 clinical trial data. The new target completion date for the review has been set for August 22 of this year. Nippon Shinyaku and Capricor signed exclusive sales agreements in the US in January 2022 and in Japan in February 2023.
https://answers.and-pro.jp/pharmanews/32029/
Note: Nippon Shinyaku's market cap is $2.39 billion
https://finance.yahoo.com/quote/4516.T/
positive
1
u/imz72
March 12, 2026
FDA Resumes Review of Capricor/Nippon Shinyaku’s DMD Cell Therapy
The US FDA has resumed its review of Capricor Therapeutics’ Duchenne muscular dystrophy (DMD) cell therapy deramiocel, also known as CAP-1002, the biotech said on March 10. The agency has set a new target action date of August 22.
The review was restarted after Capricor submitted additional materials in response to the complete response letter issued by the FDA in July last year. The filing included data from the US PIII HOPE-3 trial, which compared the efficacy and safety of deramiocel against placebo, along with other supporting evidence.
CAP-1002 is being developed by Capricor as a cell therapy for cardiomyopathy associated with DMD, with Nippon Shinyaku holding the commercial rights in the US and Japan. The Japanese company said plans for the product’s development in Japan are currently under consideration.
https://pj.jiho.jp/article/254942