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Keyword: regenerative medicine clear
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1r/DeadlockTheGameDeadlock update for 3/21/26wickedplayer4948130%91981.6regenerative medicine2026-03-21↗
commentercommentsentimentupvotes
u/SilverFan3702somehow green abrams returned783
u/secretwepSHIV GOT KNEE SURGERY679
u/kudlesYoshi HATES ability range đŸ€Ł645
u/Twippin-The-CattoYoshi when it's time to massively change the game again on a random Saturday afternoon. (We love to see it.)583
u/nottheusernameiwantMirage: Fire Scarabs now reduces enemy damage output by 20% (and +15% in T3) 1vs1 king394
u/kudlesKelvin ice path gonna be oppressive af đŸ€ŁđŸ€Ł with transcendent cooldown and t2 you can have perma ice path pretty much388
u/xippy_boivictor found dead on the streets293
u/A_HippieBuffing Abrams is hilarious work269
u/DJKirby05Graves’ tier 3 grasping hands spawns ghouls now? That’s kinda crazy ngl244
u/Ill_Celebration2902Shiv: Bloodletting is now affected by healing modifiers this means anti-heal like healbane works against bloodletting now right?228
u/tyvsaurVyper remains the epitome of balance203
u/TheTaffyManFeel a little crazy seeing Abrams buffs199
u/MTG_RelevantCardMcGinnis becoming more turret oriented and less ult-oriented This is, stylistically at least, a direction I’m down with.190
u/Glebobas-BarabasI hope this doesn't turn into a DOTA situation where every single character has a health bar of a reasonably sized elephant by minute 20173
u/Skippy-the-meme-LordYEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESSSSS!!! GREENS ARE PERCENT AGAIN!!! HYPER TANK HERE I COME!!!!163
u/LuvatrisCeleste buff is diabolical Falloff nerf is not that huge for these buffs161
u/Physical-Scratch-856breaking news: victor's kneecaps completely obliterated in 4k 240fps160
u/mizerakliddoorman range is nerfed, its joever156
u/DarkWolfPLThat Silver buff155
u/slimslyOh mo, that’s gonna krill him133
u/ExcelIsSuckGRAVES BUFFS YIPPPPEE. That wall buff is so cool... and as an fyi to all graves mains the ghouls summoned by the wall get the buffs of the tier 4 upgrades, so gravestone wall max build?125
u/BT--7275Abrams cant be B tier for more than two weeks I guess. Also, Celeste buff?!100
u/ARClegend_18My ability range stacking builds noooooo96
u/BahBaloonIt also bugged mid boss that can't be damaged..91
u/Doot-and-FuryMina's glide animation now has red haze coming out of her umbrella86
u/RaknargBro they desperately want us to play melee apollo holy. With duration extender and max riposte you can reliably hit 2 heavy melees now by the way.83
u/UllrCtrlThey treat Celeste and Silver like make a wish kids lol83
u/The-Weather-ReportValve needs to sit down and have a good, hard think about what they want Mirage to do. The only thing they're sure about Mirage right now is that they still want him to be really bad except for the 10 to 15 minute mark of a game where he's okay against incompetent players and bad against competent players. Djinn's Mark scaling being reduced along with doing no gun damage means he's not a duelist. However, his boon scaling for HP is just average, so he's not really a tank either. Valve, after all this time, still don't know if they want him to be a duelist or a tank, and have settled on him doing neither. His time to kill was already the longest in the game when things went well. He'll still be an okay "on-hit" guy, but if the ceiling is that low, I think he could realistically hit sub-40% WR once data comes in. Very usual of Valve to experiment with every option except the very obvious one.81
u/The-Invalid-OneBallistic + Expansion nerfs, plus punch nerfed wonder how the goo man will be this patch68
u/CarelessCourierIvy: Air Drop cooldown increased from 65s to 85s Ivy: Air Drop cooldown is reduced by 25% when used on allies Fucking catch me picking you up and dropping you immediately after just to get that sweet sweet cooldown reduction49
u/CoolVibraniumadding lifesteal effectiveness as a stat just to nerf vic is diabolical49
u/PAIN_PLUS_SUFFERINGNow instead of being functionally useless in teamfights for 30 minutes, Victor can instead be useless the whole game. Thank you Yoshi49
u/Drag0n122No Venator changes? Interesting47
u/chuck-me-papadamn that calico 2 scaling42
u/The-Invalid-OneDynamo: Quantum Entanglement T3 now also replenishes 1 charge for charged abilities (half effect on allies) does this just mean it halves the cd?41
u/firemembleThe Seraphim Wings change for brawl is fucking crazy. If you don't roll a gun carry on your team and they have a gun carry with this you instantly lose and there is nothing you can do about it. Even with a gun carry to shoot them in the air 60% is just stupid and you can pretty much stay in the air forever now. Genuinely who thought this item needed buffs.39
u/RodrubyAbrams buff, Celeste buff 😭 Victor seemed to be hit hard, no 1v6 diving and surviving, on one hand it's fair, on other hand - what does he do now? Nerf Mo ult, reasonable Percent health means squishies still squishy and tanks are tankier, we'll see how it changes meta33
u/RheasGarden<image> FINALLY LONG DISTANCE BITES!32
u/PastPalpitationCryWow they just killed Victor with that lifesteal change.31
u/moonjelliessmid boss bugged gyulp29
u/avayevvnonWhat do you mean they gave mcg's gun and turrets compensation buffs for her ult scaling lmao26
u/TParadox90GRAVES BUFFS TY YOSHI25
u/sirmsthey buffed the legendaries lmao hell yes20
u/CoralWarriorKinetic Pulse is longer and thicker 👀15
u/dankeykanngDialing back some of the cooldowns is a much needed change12
u/red--deadThis is a pretty light nerf to mcginnis ultimate right? Depends really on how hard the ability range item nerfs are moreso I guess11
u/Accursed_flame1A little confused by the stomp changes for Dynamo, if the goal of the previous big patch was to backload the ability for T3, they did it just fine. T0-2 stomp currently feels pretty awful to use in lane, so even less damage on its tiny range just, strikes me as odd. Its fine, I'm just surprised Yoshi feels the prior changes werent far enough.9
u/Doot-and-FuryThe Fall And Rise of Shiv's Mobility8
u/OxGeNiDCan anyone explain to me how shivs bloodletting was nerfed like im mentally challenged because i actually might be7
u/Winter0808can confirm after a game, mcginnis ult build is still broken6
#SubredditTitleAuthorUpvotesRatioCmtsScoreSentimentKeywordDateLink
2r/mdphdMy Sankey + Giving Back to the Community :)Useful-Bed43963680%5376.1regenerative medicine2026-03-21↗
commentercommentsentimentupvotes
u/Straight_Armadillo32Holy goated congrats!! Well deserved As :)) im also hoping to apply MD PhD but super anxious and dont know if I can make it25
u/Ill_Sleep_589idk anything about the MD/PhD program at UW, but I do know that it’s a beautiful and vibrant place to live! Always moving, squeezed between 2 lakes, and the area is gorgeous.15
u/Sauceoppa29Lisan al gaib level snakey right here. Congrats on the many many As!7
u/Useful-Bed4396[deleted]6
u/Fresh_Market6588okayyyyy miss goldwater I see u!6
u/itsfriccinbatsI’m at UCSD — feel free to PM :)5
u/ChipotleisAssCongrats bud, this is huge. An acceptance to MD-PhD program a massive W. My Aunt did her MD/PhD at UW then residency in Canada, so good luck in your desicion, any school will be lucky to have you :)5
u/SatisestCongrats on the results. Stanford is the best program on your list and perhaps in the country. Highly recommended unless you have specific research interests elsewhere. The MSTP is very cohesive so dual degree students stay on track and integrated into both programs.3
u/Theloveandhatehopefully I'll see you at Stanford this summer <33
u/Increase_CraftyHi, I saw you mention research fit on another comment; are you referring to your own research? as in your own work needs to align with what the university has a big focus on? Or your goals as in you’re interested in xyz field, and that university has a focus on that xyz field? Also congrats and tysm for the resources!3
u/Party-Coffee-4067wow congrats! also thank you so much for the notion. quick question on the LOR’s. How did you build a good relationship with faculty beyond just going to office hours and performing well in class? i feel like im not really standing out at all in this regard.3
u/Ace_PossumHow many PhD programs did you also apply to? And was the plan to see how things were going for MD-PhD applications and then decide if you wanted to apply for PhD programs? I’m considering doing the same but haven’t seen too many people do this. Great to know it is a possibility, so thanks for sharing!2
u/Ices10Would you have taken UCSF > HMS and Stanford. Huge congrats! In a similar situation lmaoo deciding schools.2
u/majormajormajormajoHow did you answer why you needed both degrees?2
u/AntiMarkovnikovFishAmazing stuff! Mind if I ask when you had your secondaries submitted?2
u/Thin_Cold_9320Sir, im going to have to see your whole application and see how it fulfills the core competencies lol1
u/Positive-Sell-5424i know sinai has a really well-known heart center but i don't know much about research there. is location a big thing for you? i think that's a great way of narrowing down your current options1
u/Temporary_Skin5145Wow, congratulations on your As! Honestly, hearing that the writing is a big part of making an applicant stand out makes me feel a bit better about my application. My writing is very strong and I think I've written a pretty cohesive narrative, but I was very worried it wouldn't matter much compared to my stats. I've got low clinical experience from having to work full time on top of all my stuff and, while I know MD/PhD is what I want, I've been really worried I'll get nowhere because of it. I'm kind of in a similar place to where you were where I'm thinking about applying to PhD programs since I don't think I'll get into an MSTP. It's been very nerve-racking.1
u/Fun_Taro9685Congratulations!! Wishing you all the best. I am also applying to MD-phd programs this year. I would like to connect with you.1
u/AmbitionJaded3177Any advice for younger people starting their premed journey? Im a high school senior interested in doing an md-phd but im super lost about how to start and pace myself so hopefully I can have a successful application cycle like yours!1
u/Dyllidogliterally insane. Holy research hours1
u/CandyPossible6197đŸ„łđŸ„ł congrats!!1
u/Euphoric_Season_2475Can I dm?1
u/jaybsuaveChad1
u/Cadee9203This sankey making me feel insanely under prepared 😅1
u/Ok_Introduction8591congratulations!!! can i ask how your perspective to apply md-phd as someone in between phd only & md-phd was shaped by your clinical experiences?1
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3r/singularityIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz740%26271.2regenerative medicine2026-03-10↗
commentercommentsentimentupvotes
u/ImmuneHackThis is the kind of reductive thinking that plagues discussions about AI and the future: imagining extraordinary breakthroughs in one area while assuming inertia everywhere else. It leads, paradoxically, to imagining a civilisation advanced enough to solve ageing while importing all of today’s limits in every other domain into that future vision of the world. To be clear, my point is that the same breakthroughs required to solve ageing would probably coincide with major advances in automation, robotics, land management, energy, agriculture, desalination and food production. Meaning that population control in such a future might not be as much of an issue as it appears from today’s vantage point.114
u/H_A_A_K_O_NYou still need new people. A lot will die from accident, murder, wars, suicide.63
u/CryptizardIf every human is allowed to have one child then the population will stabilize at exactly 2x its starting level. If we have the tech to cure aging then we can definitely support 2x the number of humans, so no problem.47
u/Appropriate-Tough104If we get there we’ll probably also solve energy and space travel so can expand our species to other habitable planets18
u/rlanham1963None of us know what even advanced AI will do to life in 5 or 10 years. Speculating on massive social events like an end to ageing is effectively impossible to do with any foresight. We are on the cusp, even without ageing change, of the greatest social change ever. And no one knows nor understands the implications of dramatically less work, dramatically less cash flowing, dramatically lower real estate values as investments, etc. etc. These things have never (ever) happened before. One looks to things like the Black Death or the rise of modern public health medicine (mostly chlorinate water) to see equivalent changes to even begin to compare. And those are not close. Watch programmers. As they go away (and they are) you will see, first, peak employment, then peak despair, then acceptance, then change. How? Implications? The smartest and deepest thinkers can only guess right now.11
u/blueheaven84Not having kids is a small price to pay. I hate that people aren't sure between 1. having kids and 2. NOT DYING10
u/FiresideFox05I really think that the ‘eventually’ there is doing a lot of very hard work. Odds are this shit would only be available in modernized / industrialized societies, and half of those are working their way to a slow demographic collapse, East Asia in particular. It would take South Korea or Japan hundreds of years to reach any meaningful degree of overpopulation if the old people stopped dying; by then, it’s seem as if the planet or perhaps the solar system would look so different there’s really no sense bothering to infer about it.7
u/Virtual_CrowIf average number of kids is less than 1, then no. If the number is 0.5 (average couple has one kid, and all their kids' couples have one also etc) the population only doubles eventually. With random accident mortality and the trend of people to not have kids as they get richer, it's probably not an issue.5
u/peterflysI think we’re forgetting the prospect of transhumanism and posthumanism. Why would we stop at biological longevity? We won’t. Once we figure out how to interface our brains with AI, we’ll move our consciousness out of our bodies. Biological breeding will stop.4
u/ioneticLaughs in microplastics.4
u/MisterBilauIf we can completely cure aging (as in biological immortality, not just extension), we will have the tech to expand to other planets. Probably easier to do, actually - we kinda know how to do it already, it's just a matter of resources, whereas we're very far from achieving immortality from a tech standpoint. Then "overpopulation" will be a non issue.3
u/oadephonIf there's enough abundance in healthcare to solve aging, there will probably be enough abundance in everything else to support a growing population.3
u/GreasyRimFrankly, it looks like we're becoming uninterested in reproduction, at least in the US.3
u/Strange_Sleep_406lol lmao even3
u/bigdipboyNo they’d just sell immortality to the super rich and everyone else would still die3
u/AcrobaticKittenAs far as I know if you'd cure aging the lifespan would be 500 years max, even though aging is stopped life threatening risks are still there.2
u/NegotiationWilling45This problem will have any number of currently unforeseen factors that will impact the answer. It won’t be today’s world at that point.2
u/ziplock9000What they did in China would have to happen. Assuming we don't vastly increase technology and put bases on other planets.2
u/SmugPolyamoristThere's a lot of whatif's to consider. A few are; Fertility rates in developed countries are already heading well below 2. Would this reverse? Perhaps, if you're eternally youthful. Will the fertility rate trend be reversed by selection pressure?(orthogonal to your hypothetical really) Is a society where we've cured aging but not expanded into space or massively densified earth likley?2
u/[deleted]With AI and most likely super abundance, there would be no reason to ban reproduction. Also, we won't have governments run by humans anymore. Plus with the advances in robotics and synthetics, we probably won't even need biological bodies anymore. That would also cure aging. And as another commenter said, with the advances in tech we would probably expand our species out into the stars.2
u/ExoTauriWe're gonna need a shit ton of people to be able to populate the solar system, so no.2
u/Virtual_Plant_5629i'd be really curious what kind of timeline has it taking until 2050 that's an insanely long time at the current rate of advance. even without AI that would be a really long timeline. with ai.. it's an eternity af2
u/TheRebelMastermindThey will ban reproduction as soon as they find out how to make that happen in shit countries. Regardless of aging2
u/StahlbodenBirth rates are declining accross the board and children are sort of symbolic immortality so with cured aging, people would have even less incentives to make babies. Adding to this the fact that deaths unlrelated to aging would still occur, and we might have sort of a balance.2
u/MeasurementOwn6506The peons of the world will have been made artificially extinct through various initiatives i.e. another COVID, chemicals reducing fertility in foods and other means. So this won't be an issue2
u/Stamperdoodle1If humans ever cure aging - The only thing that would happen is the ultra-rich would live forever. Our lives would not change at all.2
u/PulselovveWhy wouldn't they want to share the cure with you? What is their incentive?1
u/zombosisThat would only be for the rich1
u/RonocNYCIn a world of ASI human reproduction would be pretty tightly managed as it would be in a game reserve or zoo and that's probably being generous about ASI alignment.1
u/0sko59fds24By that time we are either multi-planetary or extinct1
u/1a1bPopulations in developed countries decline without immigration. Increased longevity would mean countries can reduce immigration while still maintaining population growth.1
u/Some-Habit-1428Read Scythe by Neal Shusterman1
u/clandestineVexationCure aging but not death. Statistically most people die before they die “of old age”, that’s why it’s a population pyramid and not a population rectangle. People will still die of other causes even if biologically they could live in perpetuity. Maybe it will balance out and solve the western birthrate crash problem1
u/New_Public_2828Aren't they trying to do that now indirectly? Puts tinfoil hat back on1
u/Important-Figure-512I think people would need to kill themselves because who the fuck wants to live forever that’s like torture1
u/ThrowRA-footballWith better technology we could easily have 200-300 billion people without it impacting the environment too much. Green Energy will make pollution go away. Better food production will feed a bigger population. Better Robotics and resource extraction will give us an abundance of raw materials. And using Arcology type housing could house a bigger population.  And this is assuming we don't colonize any other planets ever, and don't also create artificially more living spaces on earth or anywhere else. This will give the world a population density roughly equivalent to Japan. So a bit more densely populated but still having lots of green spaces. This doesn't even take into account the dramatic dropping of birth rates around the world. I honestly think we won't even want to think about implementing any population control measures because of the dropping population. Curing aging might be what saves humanity from going extinct.1
u/Luvirin_WebyMost likely no need to ban. As there is basically no lack of land, earth vcould support easily 10 times the population and the solar system a million times and people do die even without aging and so on. There might be limits on locale at some times... Also I am not sure everyone wants to live forever, I mean I do as there is always something new to learn or experience, but I have heard many people voicing things that they do not want to. As for inequality: Things tend to swing in that regard, as we went from the robber barons to the much more equal thing after ww2 to current technocratic elite, so future swings in the opposite direction are again likely.1
u/pink_gobletthe level of bio-engineering and molecular precision required to halt senescence typically implies mastery over matter itself. you would solve many other issues affecting climate and greatly increase the carrying capacity of the planet by orders of magnitude.1
u/cfehunterConversely this means we get to keep all of our greatest scientific minds. It means the complete abolishment of the pension burden, you really will be able to work until you die. Whether that's a good thing or a bad thing depends on whether you enjoy what you do I suppose. A lot would need to change, absolutely, but outlawing reproduction isn't likely. You'd be immune to ageing, not death. Sooner or later, we're all going, no matter how good medicine gets.1
u/NotAnotherEmpireWith current birth rates in advanced economies, that seems unnecessary.1
u/LymelightTOWe already live in a world where the TFR is precipitously dropping as people in developed countries choose to delay having children later and later, sometimes indefinitely, as they exit the fertility window. If you cured aging, presumably making the fertility window indefinitely long, I would expect people would choose to defer having children much longer. Also, this assumes addressing aging happens, ceteris paribus. If we’re curing aging, we’re likely resolving scarcity altogether, shortly thereafter. I wouldn’t worry about overpopulation, no.1
u/MasterDisillusionedThey wouldn't have to, they'd just cull the rest of us.1
u/SilverDetail2713We can't even solve male pattern baldness. There hasn't been any real breakthrough in medicine this century... If we'll be able to keep the pace finding new antibiotics to fight super bacteria, be thankful...1
u/Whispering-DepthsDon't be silly. If we cured aging, it would be in a matter of less than a decade, not 25 years, and it would imply advancements and innovation that make that a non-issue. Solve our need for food and our ability to not re-use waste in general, and start growing vertically in both directions, and we can support exponentially more humans if we're stupid enough to keep everyone on Earth exclusively.1
u/HotKarldaltonAnyone else watch Mr. Nobody? Very fitting movie for OP's post.1
u/hideousoxWhen humans ‘cure’ aging in 2050, the cure will be available to the ultra rich. The rest of us will keep dying, even younger, while we throw turds at each other, blaming our neighbours for our ultra rich inflicted troubles.1
u/Ok_Height3499Oh, I hope so. They ought yo do it now.1
u/Professional_Dot2761Our solar system is pretty big and humans uploading is the step after lev.1
u/djkool_yankyYou need to pay for life long subscription fees to the governments. Starts at basic - diseases cannot be avoided. Premium - no diseases.1
u/MJM_1989CWUWe will need more people to colonize the stars!1
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4r/HormoneFreeMenopauseSocial pressure to go on HRT?Elegant_Cat_3644690%6069.2regenerative medicine2026-03-10↗
commentercommentsentimentupvotes
u/Overall_Emotion8878if you feel so good, how would you even know if it is working or helping? without symptoms worth targeting it doesn't seem worth the potential risks.50
u/Away-Potential-609I've been on both sides of this because I didn't go off HRT by choice. Before I was diagnosed with cancer I was having a really rough time of perimenopause and was hopeful that HRT would help. In the short time I was taking it, I had mixed results. Some things seemed to improve, others were unchanged. If I hadn't had severe symptoms I don't think I would have considered it. Regarding disease prevention... even when I was more optimistic/enthusiastic about HRT I saw that a lot of the purported health benefits were heavy with confirmation bias... the data that HRT prevents things like heart disease and dementia is very inconclusive, but if you want HRT to be a heroic remedy then why not play those up. Meanwhile the cancer risk is not zero. The survival rate for breast cancer is significantly higher in post-menopausal women because lower-estrogen is protective, and women who take HRT are forfeiting that benefit. Breast cancer risk skyrockets after age 45 and is even higher after age 65. Some pro-HRT people like to tout the survivability of breast cancer, but surviving cancer does more damage to the heart, brain, bones, etc. than HRT could ever have prevented. All that to say, the claims of disease prevention are over-simplified and leave out the real complexity of disease risk as we age. No one can know in advance whether the diseases that may come for you are the ones that HRT might reduce vs. increase your risk. Knowing what I know now, if I had made it all the way to my late 50s with few menopause symptoms, I would leave HRT to those who really need it for their quality of life.44
u/NoneOfThisMatters_XOI didn’t go on it and I feel like other subs downvote you for that. There really is a lot of pressure to do it.37
u/Winter_Bid7630With RFK Jr. and therefore the FDA pushing for the removal of black box warnings on HRT and also citing decades-old research to justify its widespread use, more and more women are giving it a try. It's also really trendy right now with a ton of social media influencers claiming dramatic health improvements from taking HRT. There's a shortage of estrogen patches right now because of this surge in popularity. My doctor tends to agree with Dr. Jen Gunter and thinks HRT is wonderful for people who are dealing with severe menopause symptoms, but thinks there isn't enough research to justify its widespread use. Like any medication, it comes with risks. So, for someone like you, who is doing really well, why take on those risks when many of the benefits being pushed by RFK Jr. and social media influencers aren't proven by research? I've been in perimenopause for 8ish years and feel pretty great. Any issues I've had have been improved through vaginal estrogen cream, exercise, and improving my diet. I've had a couple of night sweats, but the only hot flash I've had was after my last glass of alcohol, which was almost a year ago. I rarely take vitamins, get enough sleep, meditate, and feel pretty great. I'll get on HRT if that changes, but I don't take medication I don't need.34
u/scoutiedalThe studies on the health benefits of HRT are very inconclusive. Really it’s your choice. The best evidence is around bone loss but diet and lifting are very important in prevention as well. If you feel great go hormone free. I use vagianl estrogen only for GSM. I feel pretty good too.31
u/Curious-External-7It sounds like you already live a very healthy lifestyle. If you're feeling well, I wouldn't mess with that. I've seen too many comments from the other sub about the troubles some of them have dialing in the correct dosages.23
u/Zoinks222I’m confused why anyone is pressuring you to take hormones since you don’t have any issues with menopause.16
u/4travelersMom 94yo, Sister 76yo, Sister 72 yo have never even considered HRT and all have lived to tell the tale.16
u/Agitated_Eye2638HRT is not compulsory. Do what is working for you.15
u/10MileHikeI am post menopausal by over a decade. I;m going to be very frank in this post and hope I do not offend anyone. As that is not my purpose. All the women in my family live to between 92 and 100 and none of them took HRT. I do believe quite a bit in the genetic predisposition to many things, which is why I think its important to look thru one's family history. There are things we cannot fully control...they are part of our makeup. I would never discount any of the positive effects of HRT therapy for anyone doing it. But on the flip side, I don't want to be nagged and proseletized to about doing it. And the pressure the OP describes is very much alive out there. Reading deeper between the lines, it seems that many women are terrified of aging. I am not. (I discuss a bit about "mood" further down in this post.) A lot of both physical AND psychological experiences do have very much to do with how you frame things, and one's deepest and almost "unconscious" beliefs about aging as a woman. I work on myself to dispel all the myths, and belief systems that don't ring true for ME. I am not worried about dementia or heart disease, since in trying to get my lipids profile as close to perfection as possible, I started taking one of the safest and most well studied meds, a mild statin, which research also shows great great promise in preventing dimentia and alzeimers. My microbiome has improved because I am now getting >30-40g of fiber per day, and for my LDL-C and Apo(B), I consume < 10-15g of Saturated fat, which has also kept me at pretty much the same weight I was at in my mid 30s, and my cholesterol profile healthy. I also walk 3 to 5 miles a day 3x a week and swim every other day in summer.....less chance of me falling and breaking my hip because I work on my balance.. I am a huge believer in physical therapy and "movement". For both my heart, musculoskeletal system, and mood. I place more importance on not suffering a stroke, or heart event, than I am about hot flashes, mood disorders, etc. I've lived long enough to take those things in stride, life is an up and down event.....I never expected to feel at my age the same as I did when I was 30. I do accept some of the deficiencies of aging.......because there is no way around it. And I have never been a woman who worried about aging, at all. I just accepted that we do age. I always promised myself when I was younger that I wouldn't become obsessed about it. And, this may offend some: I actually think that at least "part" of the emotional distress some women experience during menopause may be directly related to how they feel about aging. And that might be good to explore. Therapeutically. I am not interested in adding any extra risk to my life... and I do believe there is some heart health risk to HRT for some people. But I am also very intentional about living a healthy lifestye and eating properly. As well as doing all the important "preventative" healthcare things that people over 65 should be doing. I get a full body skin cancer check, yearly, no matter what, for instance. I "do" however use vaginal estriodol, which is non systemic and helps a LOT with dryness, UTIs, etc. Finally, my neice had triple negative breast cancer, (the worst kind of BC), and the first thing the oncologoists (modern oncologists, in one of the most famous universiity hospitals in Calif) asked her was if she was taking hormones. Not saying it does, but there may be a relationship. That made me nervous. What she went thru for 4 years I would not wish on anyone, so maybe I also have a slight fear of the "possibility", however remote, of HRT and certain cancers. But its not an argument I even want to have. I just feel, intuitively, that I didn't want to get on HRT and so, I did not. And yes, I have noticed a very strong push in social media, that is even creeping into other health topic subs, haivng nothing to do with menopause or HRT. And that almost feels like marketing pressure or at least pushing an agenda. But I also dislike those commercials that show older people in fields of wildflowers, frolicking as if they were 20-somethings, becuase I don't think that is "realistic" for many people. I have my aches asnd pains, just like many others do. I used to play tennis 4x a week.....I can't do that anymore, so I do other things that I CAN do. I don't think we can control everything. At my age, I have become a more patient and accepting human, and my overall attitude is "I do what I can." That is what everyone should do. Do the best you can do for yourself, that aligns with YOUR belief system, values, and deeper intuition. Examine it and decide. Then, carry on with confidence and belief that you made the right decision for yourself. Just smile and thank the friends pusing you about it, and tell them, you are glad they are getting relief, but you are pleased with your decision (if you so decide that way).15
u/BuffalippoI could have written this! I also feel the social pressure from my friend circle despite being extremely active, fit, and healthy. I basically have no reason to go on HRT but I feel immense pressure to.11
u/Reiki-RakerAdrenals are supposed to make the transition smooth but a lot of people haven’t taken care of themselves and their adrenals are fried. WHO released that birth control is top level cause of cancer last week. I wonder how long before HRT is the same by WHO. I do not trust one thing our Federal Death Association approves of.11
u/GrdngirlMy boss is on the highest does of HRT and while it helped with her sui@idal ideation. She still had anxiety and sleeps like crap. So it’s not all roses on the other side. I’d i’d say try it if you were completely miserable and it was affecting your everyday life. But you seem to be doing pretty well and you don’t seem to be too bothered by that many intense symptoms. So I would just do what you want and stay off of it. It’s not absolutely necessary to take HRT.10
u/franzvonstuckPlease donÂŽt get me wrong, but I have to say it very harshly: I refuse to believe, that everything will be fine once you take HRT. It is massively the lifestyle, which influences the way you age and many people donÂŽt want to or cannot do the work or change their habits. I personally cannot take HRT due to other conditions and given how I badly reacted to my own hormones all my life, I wouldnÂŽt want to put any chemical hormones in the mix. Currently, Im roughly 6 years into perimenopause with poor sleep, hormonal migraines due to peri, osteopenia and a lot of histamine issues and mast cell activation. For many things, that HRT claims to do, there are non-HRT options you can do: Strenght training, eating whole foods with the right macronutrients, prioritize sleep as much as you can, move more, reduce stress. This takes a lot of effort and I do wish, a magical fairy-dust unicorn pill existed, that would do the work for me. Due to my constant exhaustion, I really donÂŽt feel like putting in the effort most of the time, but I cook with whole foods, track my macros, try to get some exercise like walking, pilates and yoga, drag my tired body to the gym and try to sleep as well as I can in this hormonal chaos. I live in Europe and unfortunately, this trend has spread here although many women still donÂŽt want to take HRT. I see mostly women, who are afraid of ageing taking it. I have colleagues, who take it and think, it is the fountain of youth. They donÂŽt eat enough calories, one likes red wine a lot and the other one even tanned a lot (still does). Both have wrinkles and saggy skin, which proves, that HRT is not the magical pill for youthful skin it claims to be. Unfortunately, I know of at least 2 women, who got cancer on HRT after menopause. One got breast cancer and the other one got the pre-stage of cancer in her uterus and had to get a hysterectomy. Due to the PR and media coverage, that HRT gets, I would be lying, if I didnÂŽt admit to be scared of osteoporosis, heart disease and dementia. Every doctor and menopause specialist recommends it nowadays. But it is too simplified and one-dimensional sometimes as you can get osteoporosis from other things than just the loss of hormones. What about your vitamin d, your calcium, your muscle strenght and type of workout? And some illnesses can cause osteoporosis like my mast cell activation. ItÂŽs hard, but I donÂŽt want to take HRT and only time will prove, if my decision is right for me.10
u/Cat_From_HoodTime to find some new friends 😂.  Why would you take something you don't need?  It might make sense if symptoms are bad enough to trial.  Personally think it's better to focus on general health to make things go better.9
u/ServiceKooky1323A lot of the Dr influencers who sell books recommend it (Vonda, Haver).8
u/blondy168HRT doesn't solve everything, that's for sure - I'm listening to a podcast of Dr. Mary Clare's right now, she is on higher doses of estrogen (patch at at least 1.0 I think) and 200 mg Progesterone and says she wakes up at 3 am without fail and can't get back to sleep - doesn't sound like a ringing endorsement of HRT to me. I found the same thing tried it once and it did nothing but wrecked my sleep. My experience.8
u/evefueI have seen it, too. I wasmicrobiology. In it for brain health, but my doc said that there isn't much evidence to support that it is preventative against dementia. I otherwise feel pretty good. I am not against it and am open to it if things go downhill for me, but not for now. My doc did say she was pushing people to take care of their microbiome.5
u/AlinaNightroseI didn’t do it either and yeah, the sub acts like you committed a crime. Exhausting.5
u/rulytempestI wish it wasn't so but I've tried HRT twice and both times had to give up and remove the patch. It always seems to work so well for the first week or so. Like I feel amazing! Anxiety disappears, I'm clam and sleeping well. Then the side effects of the HRT start to ramp up. Instead of calm I feel like Weepy PMS, wanting to eat everything in sight. And this last time the breast engorgement was crazy. I felt pregnant. These are things I don't want to feel again at my age!! Many suggest I should just wait it out for a few months. But I just can't handle it. I suspect I have progesterone intolerance. I will say I have had great success with vaginal estrogen for prolapse and dryness.5
u/Thin_Risk7778As a breast cancer patient who can’t use HRT, I appreciate stories from people doing very well without it :)5
u/Meesha1969I think there is a world of difference between HRT from years ago and HRT today. I think it’s important to trust your inner voice. Being sceptical is okay but don’t let yourself suffer unduly. I’m unable to use any kind of hormone treatment. I would love to try it. I have had hot flashes every two hours for over 10 years and haven’t had a full nights sleep in all that time. I sooo want to get a full nights sleep if for no other reason than to be able to control my junk food cravings, but also, the fatigue and brain fog are so severe i feel incapable of doing most things.4
u/Brilliant_Meet_2751I agree, I’m 48 & feel good I do have random hot flashes & zero sex drive but I don’t feel it bad enough to try HRT’s. I take Black Cohosh a few times a week it helps w/hot flashes. Sex drive I have found anything to help w/that one yet.4
u/Affectionate-Map2583You sound similar to me. Why mess with what's working? I never tried HRT because I went through menopause without too many issues, all while not going to the doctor for a few years due to needing to find a new doctor and avoiding their offices in general during Covid. By the time I went, the doctor said "are you in menopause" so I said yes, and she said "and that's going okay for you?" (yes) and that was the end of that conversation. I have seen stories on here from women who had issues with being on the hormones, so that's definitely a possibility.4
u/Marvellous_WonderHave you though about NEM for reducing the chance of bone loss. I have been using it and it has really helped to reduce my joint pain. I also take marine collagen.3
u/AlinaPetalwindEvery body is different. What works for the majority isn't a universal rule.3
u/AmaraStarcrestI didn’t do it either, and people definitely downvote you for that2
u/AylaMoonpetalDidn’t go on it either, and the downvotes came fast.2
u/cookingismythingI didn’t go on hormones for a while but then the symptoms became too much and was affecting my everyday life. The night sweats were bad but mostly the mental fog and fatigue. I couldn’t function at work. So I’m on HRT now it has helped me tremendously but there’s no judgement from me. Peri lasts so long and symptoms come and go. Women have done it without help. Women have done it with help and women have had some help for periods of time. You need to do what’s best for you.1
u/[deleted]You can’t even go to any skincare sub these days, under almost every post there’s a suggest to start on HRT. Some truly believe it’s some sort of fountain of youth and makes them look 15 years younger. Yeah, riiight.1
u/themainkangarooI think the only pressure is on-line. I am 63yo, use estrodiol cream but have never discussed this with friends my age, so there no pressure there. I have no sisters & my Mom was never on any hormone (she 90yo). The HRT push is an annoying on-line, media thing in my experience & the only reason I see it is within Osteoporosis discussions -- much bigger push to take bisphosphonates from doctors once they see a Dexa scores below -2.5 & sometimes above that if the woman has had fractures.1
u/Acceptable_Iron_2080My mom is now experiencing the repercussions of never taking hormones through menopause and beyond. If she had to do it all over again, she would take it. Go to a functional medicine doctor that will test your blood thoroughly and take their advice.
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5r/EpsteinCan we talk about Don Huffines (current TX Rep AG candidate) new Zoro Ranch owne...Last_Spare990%2567.9regenerative medicine2026-03-23↗
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u/InterestSea4061This should be heavily discussed18
u/Either-Strain-1506Bumping and adding the original author link https://www.facebook.com/story.php?story_fbid=1311074210836987&id=100058032612092 And separate video summary by SweetandSaltyLin  https://youtu.be/VwqvbyMHX54?si=5v5NcuqSOeIKRsXt13
u/FrogsInASweaterJE purposefully curated intellectuals from the rationalist movement of the early 2000s for the purposes of greater exploring the potential behind transhumanisim. Founders of the movement and many prominent individuals feature in the files hundreds and hundreds of times in total. This includes people like: John Brockman Eliezer Yudkowsky Scott Alexander Nick Bostrom Peter Thiel [the big name most are familiar with] Michael Nielsen And so many freaking more with dozens of orgs linked to these individuals [and breaking research in transhumanisim topics, everything from cryogenics to what OP is discussing] also being discussed in-depth from creation to agenda Some of these folks got into politics, and some got into finance and investing. All of which need to be questioned because this was a large part of his focus and easily crossed over into every other issue the files holds.9
u/Sterlingsgma1I heard survivors talk about this place for a couple of years. About the underground levels. Complete OBGYN setup with operating room. Speaking of waking up while in stirrups. đŸ˜“đŸ’”đŸ˜ĄđŸ€Ź There's ALWAYS been a reason they didn't search here. Just a conspiracy though huh?! Just as there was a reason this manđŸ€Ź purchased it at a discount. I'm in Texas and we DO NOT want him!!!8
u/BoredtopherThis guy couldn't even muster enough support for comptroller, hes not going to outcorrupt Ken Paxton now6
u/PsychedelicSarcasmYeah, he's openly advocating eating fetuses,6
u/Boopy7Okay -- some time ago, in the first admin when they were separating even infants and tots from moms, there was a lawyer who even had a three year old for a client, I kind of joked (but not anymore joking) about how they were rounding up families and getting hold of the kids for not only sex trafficking and indoctrination, which did actually happen, and infuriated me, but ALSO I said they were planning on harvesting spare body parts and getting blood (similar to Chinese concentration camps.) I was kind of kidding back then. Now? No. Thiel already gets hold of young blood to pump in and there are actual blood harvesting sites in India (I saved the long ago finds on this, somewhere on my computer) and I sort of kept an eye on whatever shit they were doing on longevity forums. Nothing wrong with synthetic or decent sourced stem cells, mind you. Or research into how to cure cancers. No. This is not my problem. My problem is I do not trust these people when they say they are "ethically sourced" bc NOTHING ABOUT THESE PEOPLE HAS EVER BEEN ETHICAL OR TRUSTOWORTHY. In Russia, Putin stays alive far longer than he might have bc of very shady surgeries and treatments, and Ukraine soldiers don't return if captured. This is happening here, while they steal from our country, and raid the coffers of others too. So of COURSE humans are part of what evil men feel they are entitled to raid, rape, and defile. If you look at a picture of this particular asshole who owns Zorro, he literally looks like he cut the face off a child and stapled it onto his own, like a demented elf. I recall seeing him and joking about that BEFORE I ever saw those masks, ironically enough.3
u/Lost_Equipment_3289His brother owns a large car dealership in fort worth/dallas tx area.  He had no opponent to run against so there was no losing. And he is someone every american and esp texan should heavily watch. He should not feel safe in Texas.3
u/QueefSeekingMissileEthically obtained baby hearts. Jesus Christ.2
u/This_Salt7080Im asking this just for clarity sake: is his company the ones involved in the research, or is it a company his company invested in? The wording of this makes it sound like Hest made a $1.8 milliom investment in secretome.1
u/FaerieKnotz"secret to me"1
u/AutoModeratoru/Last_Spare please reply to this comment with submission statement and files numbers or link to them if posting a released file. Your submission statement must explain why your post is relevant to the r/Epstein community. Posts without a submission statement might be removed at the discretion of the moderators. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
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6r/MorimensVortice Early Theorycraft Breakdown/DiscussionGyRNi650%2966.6regenerative medicine2026-03-06↗
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u/monchersDamn all these pre release reviews are crazy high effort. I will wait until she is released lol.10
u/LieLikeVortigern_Even if it's still soon to tell how she will work, I enjoyed reading this. Well done!4
u/thebizcuitI wish Dora was this interesting :( he came like 2 updates too soon ig3
u/ZeitzbachCorpo / Vortice / Murphy / Gmurphy is what I'm looking to play her with. My Lemurian side just use borrowed whale Gmurphy anyway for an A5 team so my OE Gmurphy is available to join this. Her ramp playstyle heavily support 6-turns battle. You OE Gmurphy on turn 1 to ramp up and generate tentacle while stalling with Corpo and Murphy shield and sacrifice removal that also ramp up the tentacle damage. Since she scales off Realm Mastery, you can just use the Nautila wheel and you're pretty much guaranteed a good amount of shield and can throw in White Stance Waltz if needed. Rouse Gmurphy and Vortices to ramp the damage side. 5 turns is more than enough to build up a lot of stuff with how fast you can cycle through the deck with Gmurphy+murphy Arith recovery and card draw into a discard if necessary to play more stuff. Then trigger a DR to fill up any missing Aliemus for a final Corpo Exalt or OE (since you're going to be expected to use her exalt to cycle deck) and on turn 6 you just go all in with all the exalt to do a big nuke into Sacrifice. The enemy chance of surviving a sacrifice stack is very slim or they will be so close to death the 2nd tick will kill them anyway. I might build a Returnal Line covenant if this works great in A5 so Vortice won't have to use the Deus one I built for Karen. All the extra tentacle hit is needed here with some wheels like Murphy wanting more hits to get as much Aliemus to reach the 5-exalt usage for Pursuit bonus.2
u/ReizeiMakoIt’s very helpful. Thank a lot!1
u/Cross_TossShe might be the first real Returnal Line user due to her stacking of Realm Mastery. 2-3 Stacks of Tentacle Gathering every turn potentially adds up long term especially as you ramp TDMG. No Gathering in Divine Realm1
u/Cross_TossBone-Chilling Embrace: Sanga's Posse provides +1 Tentacle Gen, Arith and some Delayed Shield. One of the few ways to generate Tentacles outside of Aequor units. It's either, not and1
u/Cross_TossSanga: White stance in Divine is a very easy way to generate massive shields for OE nuke cycles, but there is some antisynergy with eating Tentacles. Has TDMG stacking via Soulflare. Also Rouse, and can generate tentacles with her 4-cost, though it's extremely expensive.1
u/LinaseraHad a great time reading this. I'm so excited for her.1
u/Upstairs-Escape5778I was reading this and was surprised that base Murphy is not mentioned. Once Murphy is roused, she generates a temporary tentacle per murphy card played. Would that not help in Vortice ult? Or is there a specific caveat here which I've overlooked? Regardless, this was a very enlightening read. NGL, as cool as Vortice is, this one might be a skip for me. Fully F2P so lacking funds rn trying for E1 Horla, then Arachne after. I might consider picking her up on rerun though. RM scaling divine seems to be a cool novelty.
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7r/GracerobloxCraven but as a dw toon.foxyfan37_1987680%2666.4regenerative medicine2026-03-24↗
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u/Available_Mud_911WHAT IS THIS8
u/manfacewizardso is rue related to craven or something in this or like (i like the idea of grace entities in dandy's world for some reason)7
u/om0ri_here's my take on this kit, with an updated description! Craven the Raven Description "Craven is a brave doctor, who can protect anyone from danger!" ...At least that's what he wants you to think. His true self is that of a paranoid coward, but he almost never shows that side of himself. He's always eating too much, and sometimes steals food, but you'll forgive him, right? Abilities Malicious Medicine (Passive) Whenever Craven is buffed, the effect of the buff is doubled, but Craven gains Tired III for 3s after. (edit: removed the second ability)5
u/sillyguylulzfire3
u/Slight-Real001woowowowowowow it's craven3
u/AmongUsSigmasiIs this a creating site of some sort except the art?3
u/ThunderLP15they adding anyone to gardenview these days. Also implies Slight is here, as well a form of addictive substance that Craven fell into (ichor mayhaps)3
u/JoyousLilBoyWill there be other grace toon drawings2
u/Aggravating_Run6179Cool!2
u/Primary-Base-7662GIVE ME KOOKOO and FOOL AND YOU HAVE MY SOUL2
u/Ok_Juice7052I thought Twisted Craven will be like When it snapped (beheaded)2
u/toast-the_gooberok2
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8r/medicineWhat are clinical challenges in your specialty/occupation that needs far more at...Metsaudu330%5365.6regenerative medicine2026-03-17↗
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u/WayBetterThanXangaSingle biggest challenge for the U.S. population is getting patient to exercise more, eat better, and take medications as prescribed. You’ll prevent far more morbidity and mortality with this than any new drug or technology.235
u/FlexorCarpiUlnaristhe combination of multiomics, AI and quantum computing My patients need reliable access to food and a home free from physical violence.194
u/M1CR0PL4ST1CSif I have to read another post talking about the potential for “AI” to revolutionize medicine I might actually have a stroke192
u/basketcase0a0I would like research on how to get rid of AI. The next patient that tells me they asked ChatGPT about their symptoms might cause me to retire.112
u/Nivashuvin”multiomics, AI and quantum computing” has to be the most bullshit trifecta I’ve ever heard. It makes me physically cringe. It also makes me question if most of this OP is written with or by AI which I just can’t take seriously.81
u/RealAmericanJesusHonestly the biggest problem in my life is the technology sometimes. I've been in healthcare since the days of paper charts, med carts and phones that connected to the wall. I feel like the more that technology expands the less time I get actually having patient facing time and the more time I spend looking at screens. And some facilities have these insane expectations around patient messages that assumes infinsae availability to answer questions about what their chatbot diagnosed them with where you have to answer them within a limited time frame. And I use to be able to just call their pcp up and talk med changes but now it's impossible to do that do I'm having to click through a million different epic connects cause I work in psych and my parents aren't good historican. It's a constant routine of clocking boxes opening systems and closing them and writing things in one document and parting them to another because the good EHRs are super expensive and so clinics don't invest in infrastructure so have a basic note aggregator that crashes every 5 seconds. Like the more the technology tries to make my job easier the more I am bogged down with tasks that I'm not reimbursed for at many places and the harder it gets to coordinate care with other provides and agencies and the less face to face time I spend with my patients cause I'm basically held captive by a screen and the every growing tasks of 'innovation"54
u/vonRecklinghausenID...gesture vaguely everywhere25
u/hippoberserkIn anesthesia, intraoperative care is really good. The place that needs the most work is pre-op optimization and conditioning. We can take increasingly sick patients to the OR and get them to 30 days post-op. But whether it is pre-op anemia or nutritional status or exercise capacity, etc so much more can be done21
u/Fragrant_Shift5318Degenerative disc disease lumbar spine . A lot of the treatments just aren’t effective. They can help manage pain, but don’t always prevent disability chronic pain and loss of function.12
u/chiddlerMidlevels with high quality study design I suppose.9
u/tea-sipper42Imo, functional disorders. Very poorly understood by scientists, patients, and doctors alike Highly stigmatized Affect a huge number of people Significant symptom burden, disability, and treatment-related harm Patients often develop long term distrust of the medical system. I have absolutely nothing to offer them except sometimes a few sessions of physio. We don't have any publicly funded programs or centres in NZ that manage these patients. Almost none of them qualify for mental health services. It fucking sucks.7
u/mtbizzleI'm NOT any sort of expert in quantum computing. But do we really have good reason to predict that it'll significantly shape the future of healthcare? My 100% lay understanding is: (1) quantum computers are only useful at performing a function if you provide it an algorithm it can execute much faster than a standard computer; (2) there are very, very few such algorithms that have been created; (3) it's extremely difficult to find/create new algorithms; progress has been exceedingly slow; (4) most work is being done on the computers themselves, not the algorithms (5) ive heard arguments from experts that the type of problem where a quantum computer has a marked advantage over traditional is quite narrow and unusual, so it might be unfounded hope/wishful thinking to believe these will push progress forward in all sorts of domains What tasks are quantum computers going to revolutionize that are relevant to medicine?6
u/KetosisMDThe negative impact of stress on the body.5
u/awesomeqasimIn the US
let’s at least get our patients actual access to care, healthy foods, shelter, exercise etc to get ourselves up to the standards of other developed countries first
3
u/CommonwealthCommandoPsychiatry – Violence. There was a push in the 1960s-1990s to look at violence and aggression as a basic science issue, but it sort of petered out. The implications were scary, the research methods involved high distress for animals, and generally there wasn't much of an appetite for basic psychiatric research. There was some good work on amygdalotomies, but therapeutic neurosurgery for behavioral problems has a loaded history, to put it mildly. There is some basic research, but not nearly enough. We don't know enough about the decision-making process of aggression. Aggression and anger are obviously related, but anger is neither necessary or sufficient for violent behavior. What does anger to do a brain? Can we treat anger? Can we envision an anger-o-lytic? We effectively only treat aggression in inpatient or inpatient-adjacent settings. Nursing homes, group homes, etc., and the treatment there is typically just enough sedatives to keep the patient from hurting anyone. Is there a better way? There are no drug companies looking at any of this, so far as I know. The incentive isn't there, there's too much liability, the patient population as easily accessible, and honestly the will isn't there – SNFs and therapeutic schools are fine continuing to use sedatives instead of more direct anti-anger therapeutics.3
u/FrontierNeuroWhat about quality control, adverse effects, ethical monitoring and data gathering/analysis, etc. regarding the fascinating, deeply alarming, and increasingly popular practice of people injecting themselves with gray market “research peptides” from China without GMP manufacturing, including mainly GLP-1s like retatrutide (yes, the investigational triple agonist that essentially cured MAFLD/NAFLD and obesity while on it in clinical trials) and tirzepatide, but also a whole bunch of others? It appears to be a massive subculture already, as shown on GLP1 Forum and various subreddits.2
u/wrathoffadraBeing protected from RVU based surgeons.2
u/Full_FrontaI_NerditySomething like a continuous glucose monitor, but for women's hormone tracking, would be a godsend.1
u/nattcakesAs great as gene therapies and multiomics are, they aren’t worth a whole lot if there are no medical geneticists. I’m not sure if this is a problem specific to Canada, but some provinces literally have 1 or even 0 geneticists.1
u/MetsauduStarter comment: What are major unmet needs currently faced in your field, that are yearning for new therapies or solutions, but to which either industry and academia has yet to look into? Why in your opinion has it been not paid attention to - is it technological limitations, scientific unknowns or healthcare policy misalignments?-15
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9r/IsaacArthurIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz330%4965.4regenerative medicine2026-03-10↗
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u/NearABEThere is always a limit. There are ways to die other than aging.35
u/tarkinlarsonNo, in short. Your conflating many different problems. The Earth is not overpopulated with humans and can host many more. We are just unfair, greedy and wasteful. We can feed the entire population now, but people starve because of human action or inaction, not the Earth's carrying capacity. Even ecological damage done by humans... that's our fault. Fix that before banning reproduction and you'll solve many more problems. Demographic shifts are economic and social concerns... if you stop and eventually reverse aging... retired people become more productive again. They do not need retirement homes, pensions, etc etc. Healthcare will be less strained. All the fears that Korea Japan and other aging countries have go away. People will likely have fewer children anyway or spread then out over longer times. Assuming we solve cancer too as that's linked with the DNA damage from living a long time... long term soace travel becomes easier and less hazardous. I assume 99% of people will remain on Earth though. The real problem would likely be wealth accumulation in the elderly... already a problem in many places and it would likely increase inequality to even more gross amounts unless there is a major reshift of our economy and social values.30
u/Great-Gazoo-T800They wouldn't even bother trying, given the amount if upheaval it'd cause.5
u/kurtu5Do affluent people have children? There is your answer. Aslo the planet can support tens of trillions. So don't worry about Malthus and his suicidal students.5
u/atlvfI think governments would have better luck simply banning immortality, rather than banning reproduction.5
u/zCheshireAI slop. This account is a karma-farming bot.5
u/Low_Establishment573There would need to be a serious cultural shift if a medical breakthrough like that became reality. Capitalism almost guarantees it’ll become messy. The initial uses will almost guaranteed to be the ultra wealthy, further pushing the wealth inequality ratios. Those same ultra rich will also viciously protect their ability to live forever, AND make sure they’re the only ones who get it. I can even envision them “promising” that everyone has a chance to move up to their level, encouraging folks not to save for the future because there’s no need for retirement savings if you’re immortal. Savings are money the rich don’t have, and they want everything. After the revolution and those vampire lords are “removed”, it gets more muddy. Would people be given the choice, or everyone gets “the cure” whether they like it or not? Even more complicated, who gets to decide what a good number of humans is, and which criteria is used to choose where the replacement population comes from if there are unplanned deaths? Eugenics is never great at looking for solutions objectively.5
u/InternationalPen2072If aging is cured by 2050, that implies a rate of technological progress that makes overpopulation and resource scarcity antiquated concepts. Aging will not be completely solved for a long time, though, and even once it has the population growth rate would max out at a few percent. We’d have time to adjust.3
u/LookOverallDoes the method delay or prevent menopause? As far as population dynamics is concerned what matters is how many daughters each woman has in a lifetime. Longevity matters much less, as do men.2
u/QVReditThey are very, very, unlikely to cure aging. At least within that time frame..2
u/XeruasNo I don’t think so? I think you’d have more people and more generations alive at once but I imagine a new equilibrium would be established with like people choosing to die after a few hundred years? Also birth rates have dropped with improvements to life and resource access, humans usually invest more heavily in fewer offspring instead of having loads so maybe even if we live a long long time we’d still have on average two or less children2
u/BravemountGood luck with that. That's such a massive can of worms that no government with even a hint of wit is going to attempt to enforce that.1
u/wycreater1l11Yeah, one would have hoped it comes just in time together with effective interstellar travel and colonisation. I guess a less radical step before that is to get to a O’Neil cylinder building stage or something and continually expand on that front for some time. I guess there is a lot of material in the solar system that can be converted to liveable surface area. And the step before that would be to optimise the living space and systems that sustain us on earth. Would be interesting to look into the numbers of this hypothetical demographic change (with different parameters etc) to see how much time there is until one runs into serious problems if confined to earth only. If immortality in this sense becomes ubiquitous, I wonder if there will be a major attitude shift in humans where humans generally become more calm and collected and effectively more rational. There is not as big of rush to things anymore and rather one would generally be more careful.1
u/AlanUsingRedditWas convinced this was going to be about "Pop Squad" from Love Death and Robots. You can go read the plot, but the mood is that people can live to 150 or 200, and because of this the number of children has to be greatly reduced to make space for all the old people. Unclear if this meaning is under debate online, but directly answers your question. It has some form of retort to all of your questions, although some of them I found shallow. FWIW, that takes place in a city on Earth. I don't see what the issue even is if we are in space. This is one of several reasons we need that moon base ASAP.1
u/ScottyfromNetworking“Carousel! Carousel! Carousel! Renew!”1
u/SparKestrelAssuming the aging cure keeps people very productive (say - physical capabilities of being naturally 20 to 50 years old), I think a lot of other pressures would need to pile up to cause any strict controls on reproduction. I think 2050’s economy would have enough automation to support the population up to when we can make megastructures in space. If the curse is only for the rich to start, then I think either: market pressures would cause someone to eventually mass produce the thing like generic drugs making it is so expensive due to another limitation that the biological immortals would be a small group, and you can probably have a royalty / peasantry story1
u/Tiny_Scholar_6135If humans stop reproducing they will eventually go extinct as aging is not the only cause of death.1
u/Wise_BassI highly doubt it. The more likely impact is that after an initial surge in population for 10-20 years, it would socially and culturally "sink in" that folks have a much, much longer time to have children and the fertility rate would utterly collapse. People might actually have more children in the long run (and some sub-cultures might just keep on having children), but in any given year they'd likely have much less. That's plenty of time to build denser cities, or off-world habitats.1
u/Subject_Barnacle_600You know, someone might have a more accurate equation, but I think we can actually model this easily enough as humans and other creatures tend to grow exponentially. P=P0 * exp(r*t) But... if you think about it, humans currently die off in x years so... P=P0*(exp(r*t) - exp(r*(t-x))) That is to say, we can approximately subtract off the population from so many years ago where x is the average human lifetime. Presently, we live about 75 years so... P=P0*(exp(r*t) - exp(r*(t-75))) As x=>∞ You might notice that second term vanishes entirely, leaving us back with just P=P0 * exp(r*t) So the question is, how big is that second term? Well, because it's an exponential, most of the gains are towards the end. If humans were immortal presently, you'd still be hard pressed to find anyone from 10,000 BC: https://populationconnection.org/learn/population-milestones/ The only downside is if r grows because people just keep breeding (How many kids do you really need to raise? Can you even maintain that many relationships?!) So, even if we don't have a decreasing population on the planet, the natural growth rate of humans as is will pretty much dictate life on said planet. If you live forever, even if a piano doesn't fall on you, you're still going to be a small fraction of the population compared to the contributions from that first term and the further out on that exponential you go, the more extreme it's going to get.1
u/mjhrobsonWhy? Modern birth rates are declining all on their own; and declining globally. Even in Africa which still has a very high birth rate (by comparison) the birth rate is declining... you don't need to help this along, it is happening by itself. If you don't have death by old age the replacement rate would decrease from 2.1 to 0.2 (or something) because you have stopped people dying of old age, you haven't stopped people dying. Not dying of old age is not the same thing as immortal.1
u/JOliverScottThey'll regulate the immortality first, not the reproduction. Keep the cost of immortality out of reach of the commoners so that the wealthy and elites can continue to rule for centuries while they continue to view the rest of the population like livestock to carry out the labor. Or coupled with AI and automation and there'll be a labor revolution similar to when cars replaced horses except humans will be the horses learning they've been made obsolete. Then watch reproduction regulation begin as there's an overpopulation of idle humans draining the economic resources regardless of how long they live there's still too many of them. Heck, the elites already believe that and aren't shy about admitting they want to reduce/eliminate 80-90% of the current population. So I would expect advances in immortality to be coupled with selective breeding/eugenics policies as soon as they can get the messaging right how noble it is to sacrifice one's self for the greater good.1
u/Eighth_EveEver hear the phrase "the future is here but it isn't evenly distributed." If humanity solves aging, most humans will die of old age anyway. The world where everyone gets it is alien to us. But i bet you would get a discount on the treatments with permanent irreversible sterilization.1
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10r/immortalistsECM stiffening accelerates aging. Here is all the science behind it and best way...GarifalliaPapa980%1064.9regenerative medicine2026-03-31↗
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u/GarifalliaPapaI am writing this for anyone interested in the aging biology of ECM: Aging is not confined to DNA damage or intracellular dysfunction; it is profoundly shaped by the physical and biochemical properties of the extracellular matrix (ECM). One of the most consistent findings in mechanobiology is that ECM stiffening acts as an independent and causal driver of aging phenotypes across multiple tissues. As the ECM becomes more rigid over time due to biochemical modifications and remodeling imbalances, it alters how cells sense and respond to their environment. This shift in mechanical signaling alone is sufficient to push otherwise healthy cells toward dysfunction, senescence, or pathological states. Experimental evidence demonstrates that increased ECM stiffness directly accelerates cellular aging. A 2024 Nature-family study showed that artificially stiffening the matrix surrounding chondrocytes induced senescence-like behavior, even in otherwise normal cells. Mechanistically, this involved disruption of HDAC3 regulation and impairment of Parkin-mediated mitophagy, linking mechanical stress to mitochondrial quality control failure. Importantly, this indicates that aging signals can originate outside the cell and propagate inward, redefining how we think about the root causes of cellular decline. This concept extends strongly to stem cell biology. In aged muscle tissue, ECM stiffening significantly impairs regenerative capacity by altering the niche in which muscle stem cells reside. Young stem cells placed into a stiff, aged ECM adopt characteristics of aged cells, including reduced proliferation and increased senescence markers. Conversely, aged stem cells cultured on soft, youthful matrices regain partial regenerative function. This demonstrates that the extracellular environment is not just a passive scaffold but an active regulator of cellular age and function. At the molecular level, mechanotransduction pathways translate ECM stiffness into biochemical signals. Integrins act as primary sensors, connecting the ECM to the cytoskeleton and activating focal adhesion complexes. This leads to sustained activation of focal adhesion kinase (FAK), RhoA GTPases, and downstream transcriptional regulators such as YAP/TAZ. On stiff matrices, YAP/TAZ translocate to the nucleus and drive gene expression programs associated with fibrosis, proliferation, and stress responses, reinforcing aging-related phenotypes. A critical reinforcing mechanism emerges through fibrosis. As ECM stiffness increases, it promotes activation of fibroblasts into myofibroblasts via TGF-ÎČ signaling. These cells produce excessive collagen and ECM components, further increasing tissue stiffness. This creates a positive feedback loop: stiffness drives fibrosis, and fibrosis further increases stiffness. Over time, this loop leads to structural and functional deterioration in organs such as the heart, lungs, liver, and kidneys, tightly linking ECM mechanics to age-related disease progression. One of the major biochemical drivers of ECM stiffening is glycation. Because ECM proteins like collagen have very slow turnover rates, they are particularly vulnerable to the accumulation of advanced glycation end products (AGEs). These AGEs form covalent crosslinks between protein fibers, reducing elasticity and increasing rigidity. This process is especially prominent in conditions of hyperglycemia and metabolic stress, making it a central mechanism linking metabolism to structural aging of tissues. Among these crosslinks, glucosepane stands out as the most abundant and impactful in human tissues. It accumulates with age and is strongly associated with cardiovascular risk, especially in diabetic populations. Unlike simpler AGEs, glucosepane forms highly stable and complex crosslinks within collagen fibrils, making it resistant to natural turnover and difficult to target with conventional small molecules. This has driven research toward engineered enzymatic solutions, such as glucosepane-specific lyases, which could selectively break these crosslinks and restore ECM flexibility. Chronic inflammation further amplifies ECM dysfunction. AGE–RAGE signaling activates pro-inflammatory pathways, increasing cytokines such as IL-6 and TNF-α. At the same time, stiff ECM environments influence immune cell behavior, promoting macrophage polarization toward pro-fibrotic phenotypes. This creates a convergence between mechanical stress and inflammatory signaling, embedding ECM stiffening within the broader framework of inflammaging and systemic degeneration. Matrix remodeling systems also become dysregulated with age. Under normal conditions, matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) maintain a balance between ECM synthesis and degradation. Aging disrupts this balance, often leading to excessive accumulation of stiff, crosslinked matrix. Therapeutic strategies targeting these pathways (including modulation of MMP activity or inhibition of TGF-ÎČ signa12
u/hoursweeksConnect this with scalp health5
u/AwfullyWaffleyThank you3
u/Bright_Perception147Lumbrokinase1
u/GarifalliaPapaBest scientific research:. [1] Matrix Stiffening Drives Chondrocyte Senescence and Osteoarthritis Progression https://www.nature.com/articles/s41413-024-00333-9 [2] Age-Related Extracellular Matrix Stiffening and Muscle Impairment https://www.fightaging.org/archives/2020/06/stiffening-of-the-extracellular-matrix-contributes-to-age-related-muscle-impairment/ [3] Mechanotransduction Pathways in Cellular Aging and Therapeutic Targets https://pmc.ncbi.nlm.nih.gov/articles/PMC12145204/ [4] YAP/TAZ Mechanoregulation in Cellular Homeostasis and Disease https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.673599/full [5] Mechanopharmacology of Microenvironment Stiffness in Aging and Disease https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70236 [6] Alagebrium (AGE Crosslink Breaker) and Diabetic Complications https://pmc.ncbi.nlm.nih.gov/articles/PMC6812920/ [7] Extracellular Matrix Remodeling by Aging and Metabolic Stress https://pmc.ncbi.nlm.nih.gov/articles/PMC11856005/ [8] Extracellular Glycation Crosslinks and Strategies for Their Removal https://pubmed.ncbi.nlm.nih.gov/16706655/ [9] GlycoSENS: Therapeutic Strategies to Break AGE Crosslinks in Aging https://lifespan.io/our-research/intro-to-sens-research/glycosens
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11r/collegeresultsasian girl from city bags harvard, stanford, brown, JHU, berkeley, ucla (NO hook...butterflygirl2468350%3664.6regenerative medicine2026-03-27↗
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u/[deleted]Nice try, ChatGPT ad for college consultant40
u/jcbubba“DM me to get the info on my essay writing consultant, who is totally not also me”33
u/FirefighterFine3207🧱🧱🧱25
u/TangerineKitchen2260Btw everyone, I saw her "evidence" in her dms. It's fucking edited and bullshit.21
u/TangerineKitchen2260C A P Fucking bullshit......20
u/Sea_Response3421UC Berkeley doesn’t choose its SEED scholars until later in May18
u/Comfortable-Ebb-5949holy cap14
u/pythonlover001Sounds fake11
u/Fresh_Market6588This 100% carried into my college interviews and onward, which I will be using for the rest of my life. That was honestly the secret sauce.  There is no magic trick and stop trying to pretend like there is something behind the curtain. Idc if this fake or not but if you're gonna keep vehemently asserting that its not fake in the comments then ur definitely larping lol.10
u/Standard-Song-8590Larping final boss10
u/Decent-Ad-843Does a college counselor really help this much ?9
u/No-Biscotti-6891CAP show proof9
u/Ill_Substance_1833Something is missing for sure from this story.6
u/hEDS_StrongYou lost me at “recruited athlete” Congrats6
u/SnoFox20Nice try diddy2
u/Ready_Return_5998Congrats! What were some of the "cool gigs" if i may ask?2
u/yodatsracistThis has gone a little bit off the rails. We're locking this comment thread (at OP's request).
u/Independent_Math_840Recruited athlete. 🙄
u/butterflygirl2468[deleted]-2
u/Sad-Low5753giving you the benefit of doubt -> congrats!-2
u/P1anetfa11Lol ppl salty AF-3
u/butterflygirl2468The intention of this post is to not persuade people into believing what I have written. It is to provide insight to my experience and potentially help others. If you have questions, I'll try to get back to you (I have a lot rn). Won't be sending anymore proofs because a bunch of people have criticized me for faking them by "proving" the REAL one with old acceptance letters they found on the web lol-8
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12r/PeterAttiaLongevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran300%2162.2regenerative medicine2026-03-22↗
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u/Own-Bullfrog7803Im sorry, there is no “real” board certification (American board of medical specialties) for anti-aging and regeneration. It appears to be a certificate program by a society.13
u/Earesth99I tend to question people with board certifications from Scooby Do snd friends. It’s almost as bad as being a board certified homeopathic doctor. Or a doctor of naturopathy. Hence his non-evidence based ApoB recommendations. And his ignorance of the half lives of atorvastatin and Rosuvastatin.5
u/accuracy_101Why not pitavastatin?3
u/SillyEffective4700What’s your exercise protocol? How concerning is resistance/bodybuilding-style training whilst on statins (rhabdo risk)?2
u/SFL_27Can you give the reference for "The statin evidence for APOE4 carriers"1
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13r/decayingwinterThe Ideology Of the Reikkgon Cultists Explained( fanmade expansion theory)Embarrassed_Name266180%3962.0regenerative medicine2026-03-04↗
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u/Delta_75now where did i see this picture before? <image>5
u/Punman_69hey buddy. ever heard of “crediting the original creator”? edit: you spelled reikgon wrong dumbass3
u/NotZealoussReigkon is a god and SIN worships him, the shadows are people very devoted to him (or it.)2
u/SpacedWasTakenMy personal headcanon surrounding the Reikgon faction and its cultists is that the Reikgon are an alien species originating from the planet Ossis-666. This race basically exists with the sole goal to expand, colonize, and assimilate other worlds and lifeforms into a singular, vast collective hive network. In their base, pure form, the Reikgon resemble small parasitic organisms that burrow into the minds of their hosts. From there, they gradually overwrite both mind and body, reshaping the host into a living embodiment of their deepest fears, emotions, or desires. Hangers represent misery; Hiddens embody athazagoraphobia (the fear of being forgotten); Sicklers reflect psychosis, mania, and wrath; and Skinners manifest depersonalization. The cultists act as fanatical followers to the Reikgon’s doctrine, acting as a transitional stage before full conversion into the monstrous forms encountered later. They are not yet fully overtaken, but are no longer entirely human. A select few, such as Acolytes, Cultist Leaders, and High Priests, are able to discipline their minds and establish a form of symbiosis with their Reikgon parasite. Rather than being consumed outright, they weaponize their amplified emotions and desires, turning them into instruments of violence against others. The reason the Reikgon remain a minor faction within the broader violent ecosystem of Eden-227 is that they established a forward operating base on the planet long before human colonization. However, the planet’s extreme and unforgiving climate eventually froze the base and its inhabitants in stasis. They were only reawakened during humanity’s later colonization efforts, emerging once more during the chaos of the Collapse
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14r/NovoNordisk_StockJust in: Ozempic and Wegovy found to unlock blood vessels during heart attacks. ...kiyomoris560%861.7regenerative medicine2026-03-03↗
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u/HalfInside3167Good, tomorrow NVO -5%14
u/CommercialFit9730Man all this good news are amazing,but we are on 5 years low and every day is going a new low. It is devastating.13
u/About_to_kmsGreat news. -5%1
u/Boring-Ad-3955Great news -5%1
u/Weekly_Writing7200This is getting comical. What next, ozempic cures cancer? Maybe cures alzheimer will we’re at it?1
u/Donnahue-GeorgeTon of cope in this subreddit recently1
u/Otherwise-Review-712stock to expensive, can’t afford it, might nibble a little at 20$-1
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15r/catquestionsSevere anemia in young cat – bone marrow biopsy decision (looking for experience...MaplexMochi760%561.6regenerative medicine2026-03-18↗
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u/later-g8rI have no advice but I truly hope your kitty is okay. Id do anything for my babies. Dont give up. ❀ we're here with you if you need anything.1
u/atotalwakingupBoost for support and advice ❀‍đŸ©č1
u/MaplexMochiWe decided to skip the biopsy and go straight to steroid treatment to not put her through it, as it was unlikely to be an infection. We received the tests back for full panel infections and they were negative. Now everything is ruled out except Immune-mediated bone marrow disease (treatable with steroids), leukemia in bone marrow or aplasia (poor quality of life). We decided to take a leap of faith with steroids (prednisolone). Day 4 and she’s had great energy, eating, drinking, playful, and affectionate! Her PCV as fluctuated around 9 - 15% since the first, but unfortunately during her check up today she dipped to 12% from 14% a few days ago. We opted for her 4th blood transfusion and to start cyclosporine. Our next check up is on Tuesday, and hope to see a good response to the meds. This feels like our last Hail Mary and hoping for the best, but prepared for the worst. It’s been the toughest week of my life, besides almost losing my dad to COVID, while work has been a shit show. Worked til 9pm on a Friday and had to work til 8pm on a Saturday when I’m supposed to have weekends off đŸ˜©. Needless to say it’s been super overwhelming and just wanting to have quality time with my cat. I also worry how her sibling will manage. When she’s been hospitalized he’s been meowing endlessly searching for her and it breaks my heart. Anywho - that’s my update and hope Tuesday brings good news. Looking forward to loving up on Maple and cherishing every moment with her. Thanks for your support.1
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16r/pennystocksModel to pre-screen potential multibaggersHefty_Vermicelli_802200%2661.1regenerative medicine2026-03-14↗
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u/passionlessDroneDon’t see SLS. Fake news?3
u/narayan77I expect RZLV will re-rate according to the model, if they can prove their projections by audited earnings.2
u/UnbrokenChillWould love to see PSSOF, HYLN, HYSR, and my current multi bagger HGRAF. Particularly interested in HGRAF and PSSOF. Appreciate your work. I'd love to see more of the model and how it works.2
u/Rochetechnology1Sound interesting2
u/HEK293INVAXwill be interesting to see if it catches the up and coming 10x baggers in oil production like EONR BRN YGRAF -unless you think $120 oil isn't going to be sticky.1
u/JCJENSON_Pr_Dept_6Would you mind providing links to the studies? I can't seem to find anything especially for the credit suisse study?1
u/trshmstrRequest for HGRAF, DRTS & CTM1
u/Digital_NarThe framework itself is interesting, but the reality is that most of those categories break down when you move into penny stock territory. The model was clearly inspired by studies on compounders and 100 baggers, which usually apply to quality growth companies, not microcaps in my humble opinion. That said have you experimented with compressing the model for small caps? For example focusing the score on a few key variables like capital structure, dilution risk, revenue acceleration, and catalyst density rather than the full framework. Could be interesting to see if the model behaves differently when applied to sub-$300M companies.1
u/EmbarrassedPart1256It's wild how $CAPS doesn't come up on anyone's scanners when it continually comes up on various ones I do, the same ones that I used to find $CTM @ $.18...đŸ€”1
u/Responsible_Newt9644Neat. It’s a good idea. I’ve been looking at krakens success as a recent penny stock graduate and seeing where I can draw parallels in the penny stock I own. What if your model only uses recent penny stock graduates?1
u/StealthlessCTM two straight weeks of decline btw1
u/ScarShot587CTM is undervalued right now1
u/Horror-Pack-8319Great post - thanks for this1
u/PennyPumperDoes this submission fit our subreddit? If it does please upvote this comment. If it does not fit the subreddit please downvote this comment. I am a bot, and this comment was made automatically. Please contact us via modmail if you have any questions or concerns.
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17r/HypermobilityHypermobility is seriously ruining my happinesssarah_skribblez310%1461.0regenerative medicine2026-03-26↗
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u/Hype314Hi! This isn't a permanent fix, but it may help your pain in a matter of weeks AND improve your returns from physiotherapy. Please chat with your primary care physician about adding creatine to your daily diet. Creatine helps both with muscle strength AND with muscle fatigue. So much of hypermobile pain is due to muscles being massively overworked and not strong, but creatine can help both. Creatine is very well researched. Please read this article. You'll see incredible results -- this woman was so helped by the creatine that she was able to go back to work!!! Anecdotally, I have been struggling with so much pain and muscle soreness the last 3 years. I added creatine to my diet in December (5g / day) and my pain went from a daily 7/10 to a 3/10. I work out every day now. My physio has FINALLY started working (after 3 years!!!) and I'm more active than ever. Please chat with your doctor first and read up on the side effects (water weight / bloating for 4-6 weeks, after which it goes away) and increased thirst, but otherwise, I think it may help!!! Good luck ❀20
u/Jealous-Ant-6197Same but I don't have any access to physio. Since you do, make sure the right muscles are being trained. Strength and stabilisation not stretching. Sauna, acupuncture and massages. Assistive tech like braces if you can afford them. If you have access to the resources, im sure you'll be okay, just takes mindfulness and consistency. If you dont have all the access you can ask get better, just takes a lot more effort. Im also 20 and it got bad enough to affect my studies and I had a bunch of emergency situations that got extremely bad. I wish I'd had more support coz i didn't know it could get this bad. It really sucks tbh, feels like a setback that could've been avoided but i had no control over7
u/star5stunnahHi! I am exactly the same. Even sleeping has been really uncomfortable for me. I cant stand for an hour or i already feel a lot of pain. Some days i feel like giving up but i just try to do the most in life. Things that keep me going are my loved ones, my passions, pets, hobbies. Its important you have a support system. Without that i wouldve been gone.3
u/busterbluth21So glad I found this sub. 39 yrs old and have osteoarthritis in almost all my joints bc of hypermobility. In constant pain. It sucks. And I feel like people don’t “believe” me2
u/caraneanWe shouldnt train a single muscle, it creates misalighment. We should train the who train of a muscle. Like squats, thats when u use the whole body. Also somatic movement helped me a lot, and smaller form of hanging, helped my neck and shoulders. I just grab my upper kitchen cabinet handle to stretch, i dont put weight on it. And i lay on the floor, move one arm up and move legs sideways, and then switch, and keep switching, it helps the chain of muscles2
u/IronDominionIf you are doing physio, you shouldn’t be getting weaker unless something else is going on, or you aren’t doing your exercises at home. Are you sure what you are experiencing doesn’t have another cause?1
u/star5stunnahAlso i smoke a lot lol that helps with the stress/pain1
u/Humble_Drag_6727Prolotherapy and PRP are great regenerative medicines for restrengthening ligaments, tendons, and muscle fibers.
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18r/CrohnsDiseaseWhat are some stuff that you find cool that science found for crohn'sZestyclose-Animal426250%1660.5regenerative medicine2026-04-01↗
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u/Due_Addendum_7844My son, 13, is taking part in a 1-2 year long study where they’re mapping him from diagnosis to treatment to hopefully remission. Studying his genetics, his food maps, labs, scopes and treatment protocols to try and figure out why some medications fail for some and work for others and how his genetics and diet play a role in everything. The research center he’s participating with is actually also mapping the genetics, diet and environmental links of a lot of major diseases, already following a group of new borns for their entire childhood and planning to eventually learn how to diagnose and reprogram these genes at birth and totally prevent kids from suffering at all from any major auto immune or other genetically linked disease or disorder. My son thinks it’s so cool he may get to be apart of maybe finding a preventative measure that keeps other kids, like maybe his own future kids, from going through what he’s dealing with. I just think of what I’ve read about what people diagnosed 20 years ago went through vs now and imagine when my son is a grown man how much things will have hopefully progressed for the better.12
u/antimodezWhile I'm excited it's also important to call out that things like CAR-T, let alone CAR-T without conditioning, are still at the early case report stage where we don't really know why certain one works but many others fail. I see people post random journal articles about mouse studies or a case report and not really understand how rarely these actually turn out successful later stage trials. They have just begun phase 1 trials so we're still in the extremely early stages here with not knowing how durable the response would be if you even get a response. Personally I'm more excited about the TL1A drugs. Those show a lot of promise. There's also a new singular biologic that targets both TNF-alpha and IL-23 (bispecific antibody) that's been able to be made into a pill. That's pretty exciting obviously as no more needles plus it could serve an unmet need of people who don't get full responses to the exciting TNF-Alphas or IL-23s and are having to combine two biologics. EDIT: Not sure why OP is getting down votes in the comments. While I maybe more skeptical of some of the treatments, especially when you start tossing cure around, we should all be working together to stay optimistic and hopeful for the future yet grounded. Down voting someone for their optimism doesn't help that in my opinion and makes us seem like a bunch of grumps...11
u/arlo78zLove the optimism!3
u/Intelligent_Web3887Track down the top researchers in this field and learn as much as you can. We all need to work together to figure stuff out and spread good information3
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19r/BANDOFBROTHERSOFSRNEDr. Henry Ji’s affiliationsFate-it-is270%1360.2regenerative medicine2026-03-06↗
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u/JPPS_2MY MAN! Quite the compilation! I saved this post for future reference. Thanks so much, Fate !!!11
u/SaabilThan you very much for sharing6
u/Fate-it-isChatGPT created Microsoft Excel file, but I’m not sure it can be opened in Reddit. I’ll try to make a new post and hope it works.5
u/Fate-it-isYes — here is a clean chart of the main companies tied to Dr. Henry Ji and the scientific / intellectual-property focus of each. I’ve split it into direct affiliations and indirect / transactional ecosystem ties so it is easier to follow. Henry Ji / SRNE ecosystem chart Company / Entity Ji affiliation Direct or indirect Scientific / IP focus Key basis Sorrento Therapeutics (SRNE) Co-founder; director since 2006; CEO/President since 2012; Chairman since 2017 Direct Core platform company built around the G-MAB fully human antibody library, plus immuno-oncology, ADCs, cell therapies, oncolytic virus, and lymphatic delivery platforms Sorrento SEC filings say Ji co-founded Sorrento and that the G-MAB Library was initially invented by Henry Ji; filings also describe G-MAB, ADC, DAR-T, Seprehvec, and Sofusa as proprietary platforms. ïżŒ Scilex Holding (SCLX) Chairman / Executive Chair; also previously CEO of Scilex Pharmaceuticals Direct Commercial-stage non-opioid pain platform; owns/controls brands such as ZTlido, ELYXYB, and through subsidiary Semnur, SEMDEXA / SP-102 Scilex’s official bio and SEC filings describe Ji as Chairman/Executive Chair and former CEO of Scilex Pharma; Scilex filings identify the product/IP ownership structure. ïżŒ Semnur Pharmaceuticals Treasurer, Secretary, board member since inception; tied through Scilex Direct / controlled via Scilex SP-102 / SEMDEXA: non-opioid epidural viscous-gel dexamethasone product for sciatica/radicular pain; patent family disclosed as extending to 2036 in company materials Scilex SEC filings say Ji has served as Semnur’s Treasurer, Secretary, and director since inception; Scilex materials describe Semnur and SP-102/SEMDEXA IP. ïżŒ Scilex Pharmaceuticals Board member since 2016; served as CEO 2016–2019 Direct Pain-product operating subsidiary; key marketed asset ZTlido and development programs including SP-103 Scilex SEC filings describe Ji’s operating role at Scilex Pharma. ïżŒ Vivasor Holding / Vivasor, Inc. CEO Direct Not a classic legacy SRNE therapeutic platform in the same way as G-MAB/Scilex, but clearly part of Ji’s newer post-SRNE affiliated corporate network Recent Scilex/Semnur SEC filings state Ji currently serves as CEO of Vivasor Holding Company and Vivasor, Inc. ïżŒ TNK Therapeutics Sorrento-controlled / Ji-linked through SRNE Direct through SRNE Cell therapy / CAR-T–related platform; Sorrento filings describe immuno-cellular therapy programs and TNK’s role in contributed CAR-related IP Sorrento SEC filings refer to TNK and contributed proprietary CAR constructs/IP in the Celularity transaction. ïżŒ Sofusa / Sofusa Lymphatic Delivery System Sorrento-acquired platform under Ji-led SRNE Direct through SRNE Lymphatic drug delivery using proprietary microneedle / microfluidic delivery into lymphatic and systemic capillaries Sorrento 10-K and Sofusa materials describe it as an acquired proprietary lymphatic drug-delivery platform. ïżŒ Virex Health Acquired by Sorrento Direct through SRNE Diagnostics using enzymatic + electrochemical amplification for very low-level analyte detection Acquisition announcement describes Virex’s proprietary electrochemical/enzymatic amplification technology. ïżŒ Levena / Concortis SRNE platform companies / subsidiaries Direct through SRNE ADC technology: linker-payload / conjugation know-how used in antibody-drug conjugates Sorrento filings describe ADCs as a core proprietary platform within the Ji/SRNE ecosystem. ïżŒ Virttu Biologics / Seprehvec platform SRNE-controlled platform Direct through SRNE Oncolytic virus program, including Seprehvec Sorrento filings list Seprehvec/oncolytic virus as a proprietary platform. ïżŒ Celularity Transactional / strategic tie; SRNE and TNK contributed IP in exchange for equity Indirect Placental / regenerative / cell therapy company; key tie is that SRNE/TNK contributed certain CAR-related IP and received Celularity equity Sorrento SEC filings state that Sorrento and TNK contributed certain proprietary CAR constructs and related IP to Celularity for Series A Preferred Stock. ïżŒ NantCell / NantWorks / ImmunityBio ecosystem Collaboration, licensing, and later litigation/counterclaims Indirect Main tie appears to be antibody library / immunotherapy rights, not ownership control by Ji; later became part of the broader Nant/Sorrento disputes Sorrento’s older SEC filings reference an exclusive license agreement with NantCell; ImmunityBio later disclosed claims tied to Sorrento’s antibody-library agreement. ïżŒ OQORY, Inc. Ji signed as Chairman of the Board in transaction materials Indirect / newer affiliation Public filings tie Ji to board leadership, but the scientific/IP profile is less clearly established in the sources I checked than for SRNE/Scilex/Semnur Vincerx-related filings show Ji signing for OQORY as Chairman and for Vivasor as CEO. ïżŒ The IP map in one glance If you want the scientific/IP families rather than just the company names, the network looks like this: IP / science family Main company t4
u/Comfortable-Heart529AI or anyone else can paint any sineros but sadly all roads lead to the brutal truth, the PPS3
u/Early-Blueberry838great work. where is Oorqy?3
u/Firm_Ad_8895Great job3
u/SRNEInvestorDid ChatGPT happen to find a single investor that made money from any of these ventures other than Henry? That’s a question I would love to see answered.1
u/Kmcoyne0519Thank you!1
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20r/mdphd25-26 Cycle Results and Choosing Between Two SchoolsDisastrousSpite7382250%1359.8regenerative medicine2026-03-16↗
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u/YaPhetsEzYou are going to Yale or you are crazy lol34
u/hellomynameis2983Yale is the better program. Also NYC is a train ride away if you're concerned about not having anything to do26
u/SatisestThis is pretty simple. Yale is the better program by a wide margin, and it will put you in a far better position for residency.15
u/MundyyyTI usually opt for self-teaching, which makes me not a big fan of the mandatory lectures at Pitt. Cet par (which seems like the right assumption w.r.t your research interests), Yale hands down Most people in med school have to self-study during preclinical anyway, because most preclinical curricula do not prepare you to pass Step 1. I found myself cutting class a lot towards the end of preclinical just so I could shove in more third-party Anki cards and UWorld, and I think a school with a stricter lecture attendance policy than mine would've screwed me in the end. You might as well go to the school where you have the most control over how, what, and when you study7
u/Suspicious-Shirt-296At risk of doxxing myself, I am a recent grad of the Pitt MSTP and now a resident at Yale. Would 1000% choose Pitt again and think it offered superior clinical training in terms of the complexity of patient cases, breadth and volume. To be honest, I have been underwhelmed by the quality of medical students here at Yale and their clinical performance on wards.6
u/Psychological-Toe359I know everyone is saying Yale, but talk to the MSTP students at both programs. Pick the program where people seem to help each other, and everyone is happy. You're gonna spend 1/8th of an average life span there so quality of life should be the most important factor.5
u/WUMSDocWithout a doubt, Yale will be a better experience and will open many more important doors for you. It's not even close. Besides the obvious pizza advantage, it's an easy train ride to NYC or to Providence or Boston.3
u/dardan3llaJust curious, why didn't you apply to WUSTL?
u/predisposedthinkingNew Haven little Italy is enough reason to choose them-1
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21r/RegenerativeAgWe have to change the way we look at our worldMobileElephant122230%1459.7regenerative medicine2026-03-15↗
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u/polymathicfunCan't help but think... The ultra wealthy looks at us, other humans, as livestocks / commodity... To generate more wealth for them... It doesn't matter to them that we are surviving mainly on calories instead of balanced nutrients... As long as the difference does not rob them of their excessive returns... But relating back to your content, I strongly agree on the minerals mainly being on the soil. Due to my personal circumstances, I am now maintaining only a tiny balcony garden, with less than a dozen pots. Even growing in pots, utillizing only some regenerative principles, these pots are still supporting many different organisms, including earthworms, rolly pollies, slugs, ants, snails.... I do enjoy their presence.. and my plants are still growing quite well5
u/TappindatfannyVery well done, you’re manifesto needs to become the basis of agriculture2
u/Rorschach_1Thanks it took years to come to practicing this. JADAM books were the most influential for me. We are on a half acre within city limits and it's amazing what you can do with that. My soil is so alive now.2
u/Kind-Elder1938extremely well put and very true. There are actually a rapidly growing number of folk who are on the same page, and who are re-thinking farming2
u/FastAd8669I've interviewed ranchers in Texas, sheep farmers in California, and sanctuary operators in Maryland. I publish weekly on Substack if anyone wants to follow along! https://substack.com/@fromthebackforty1
u/BocaHydroPost a pic of your garden, otherwise TLDR1
u/AnonynjaAll these AI essays are written in the same voice, it's uncanny1
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22r/tresslessPelage have presented only phase 2a. The rest of phase 2 for PP405 will be prese...Acceptable_Phase6241290%959.3regenerative medicine2026-03-29↗
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u/rdawg1234Did they actually complete a phase 2B? That’s just the financing announcement. It’s possible they were happy enough with 2A to just jump to 37
u/jgmcmillanThis press release is from October 2025. The meeting they were talking about in this article is AAD, the one that just happened on Saturday. I think you somehow mistakenly thought this press release is new?6
u/CyberBerserku/haircafe looks like you spoke early3
u/smurfsaysMost likely they shared all the data they're going to share. The open-label extension was the post-dosing period up to day 84. That is the data that was shared at AAD. The 3-month treatment wording appears to be an error if you look at the secondary outcome measures. It clearly shows that the OLE is "To assess the concentration of PP405 in plasma" at 84 days, and the presented data corresponds with the total enrollment. I don't think anyone received 3 months of treatment.2
u/refreshingfaceI’m tired boss1
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23r/stemcellsiPSC-derived germ cells show rare motile sperm in clinical NOA casesMD_Ex160%1959.1regenerative medicine2026-03-06↗
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u/InnominaAnatomicaCool, did you publish it?5
u/PrincipleSea3103I’m not involved or educated in the medical field so may explain/ask this somewhat crudely but do have this issue. Any hypothesis on how having variants of uncertain significance at the genetic level may play out with this method? Have VUS (unknown if cis or trans) at the TEX14 gene which is pivotal in instructing germ cells to form bonds during the spermatogenesis. With my variants they essentially have predicted them to cause sperm maturation to break down early due to missense instructions to use the wrong amino acids in forming cellular bonds. Would you expect that even if using stem cells, this breakdown would still happen in your test scenario because it’s at the genetic level?1
u/GlobalBox8288Great work! Hope it becomes available for everyone. How about NOA patients with SCO? Is this technology possible to create sperm from tissue samples?1
u/Sea-Direction691Great News. Could you care explain in simple language how will this actually help people with NOA to finally be able to reproduce. Like what would be the process?1
u/ResearcherExpress701This is incredible if true. Is there a publication ? And source that can confirm it? It seems that there are no publications or reports (from private companies) describing in vitro gametogenesis in humans. Without any such evidence or support, it seems it's just your words.1
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24r/DeadlockTheGameWhat do McGinnis players think about her changes?MeTaOMiTo140%2158.9regenerative medicine2026-03-07↗
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u/techpriestess_01Making me rethinking how i play McGinnis. The big things i used getting changed (medical specter scaling completely reworked). With lvl3 extra charges +t3 wall you can get 9 turrets down pretty quickly. Even if the turrets lost their slowing. Its intresting changes overall8
u/MelodicFacadeAs a support player, I'm not a big fan lol. I wouldn't say it's a complete nerf, but it feels like turrets are more reliablein dealing damage, but get blown up super fast now. So in order to get her full effectiveness, you have to be fairly tactical with placement Healing scaling with spirit is nice, but it doesn't give attack speed anymore. Since the range doesn't scale with healing, it feels like it's more about placing it on a turret or placing it on top of yourself and standing your ground, to get that spirit resist. I also think the wall changes are super nice, but 8 seconds isn't that long I don't think it's overall that bad for her to be played so differently, but I personally enjoyed the support build of going heroic aura, throwing your medical spectre in the middle of the fight, and then having this massive radius to help stand your ground as a team. I would also usually get escalating exposure and healing tempo, and the turrets would rack up damage, while I healed 70k by the end of the game I think I need someone else to play her and find a strat that makes her good with these tools, because on paper it doesn't sound too bad. The only thing I really hate is that they reduced the health of the turrets 40%, and all they get is spirit resist from medicinal spectre? I feel like a wraith, ivy, or infernus is just as much as a problem. Sure, a geist bomb or ivy kudzu bomb would melt them, but idk if wasting medicinal spectre is worth wasting on a charged spell7
u/UmikalooI really liked gun build McGinnis, so I'm sad they nerfed her primary fire. Turret spam is a fun gimmick, but it isn't as interactive, so I expect it will get boring quick. I really enjoy using barrage, I'll have to test how the changes feel. In my experience enemies rarely abuse the minimum range, but I don't play at high levels.5
u/TsumeiI have played Mcginnis as a turret focused support, an ult focused hero with unstoppable and runspeed, a gun tank, a gun healer and a gun split pusher. All of these playstyles were in different patches because valve are like cycling between making turrets viable and not viable every six months, and then the ult was too good so they nerfed the interactions that had into the ground and instead gave them to haze. (It was pretty good though, you could ignore movement limiting effects, so you ignored the ults own effect and ran at 15-20 m/s while ulting) I don't really love that she comes back to turrets being important as her main mechanic, mostly because noone in deadlock ever plays positions, they all just jump between walls and use their 7 stamina to avoid you. That was also always the issue with her using healing items; they are amazing if your team play around objectives, but when they all literally fly off into the sunset it doesnt matter that you have a big heal and a killbox. Overall this feels like some really strong nerfs to a character who was already at one of her weakest points. That said though, the turrets might be absolutely busted beyond belief, but we know that just means they nerf her into obscurity next patch cycle and get confused what their goal was with her again. Spectral wall losing its stamina penalty to people hit is also like a pretty gigamassive nerf that I don't think non-players of the ginnis would appreciate. It is literally your one way to try to force an engagement. The wall itself is sorta irrelevant in comparison to the damage boost and stamina penalty.4
u/OmnipotencaOverall, I view the new changes as a net loss due to three major nerfs: Spectral Wall is no longer reliable for stopping enemy advances now that it is a breakable object. Spectral Wall can no longer stun, meaning it cannot stop enemy urn carriers and interrupt their actions in general. Heavy Barrage + Mystic Slow is no longer an easy kill in early lanes since its base duration is cut in half. T2 is required for it, and that means giving up on the other T1 abilities. Though there are some good changes to her: Medicinal Specter T1 granting +40% Spirit Resist is quite handy, as smart opponents used their AOE abilities to counter the healing field in the past. Medicinal Specter's healing was only meaningful in early lanes and after getting T3 Max Health bonus. Now that regen amount scales with Spirit Power, the output curve should be smoother. Mini Turret gaining 50% longer base duration is a nice change, since its previous 24s was simply too short, demanding T3 rush and at least Duration Extender if you were going for a Turret build. Spectral Wall T3 spawning additional Mini Turrets is an interesting change. Previously, the second ability to master for a Turret build had usually been Medicinal Specter due to T1 rate-of-fire bonus and Healing Tempo buff. They changed it so that you now have a different option to consider. Spectral Wall, applying slow to enemies it passes through, is a welcome buff. It is now easier to trap the enemies who attempt to flee. I understand why the wall had to change, since it never felt good for the receiving end to get walled off and stunned at the same time. Nevertheless, it feels like I lost a strong tool that used to dictate the teamfight (especially with Echo Shard imbued on wall). It is still good for kill-catching, but as I climb through the ranks, it will be less effective as the enemy team will dismantle her wall to save their teammates. Her other abilities... are okay, but will always suffer from being a stationary deployable, and never be as impactful as pre-nerf Spectral Wall.2
u/ManicPixieFuckUpI'm kind of bummed. My favorite thing to do in the game was drop a bunch of turrets and medicinal specter on a walker or shrine and melt it before anyone had a chance to react. I don't totally know if I'm gonna play her much now. In theory you could do it with healing temp but then, you know, you gotta buy healing tempo instead of mobility options. But then again, they made her model look really bad and I got over that, so, I dunno.2
u/Zerginfestorfeels like a damage reduction overall, most people in higher ELOs just burst the turrets before they can do anything, even in late game. Feels like they want you to play like a TF2 engineer gunslinger, throwing out turrets without a care to apply more DPS, instead of an actual nest to apply as support for your allies to fall back to. Biggest drawback is they still don't allow you to drop turrets as fast as you can click the button, so there's always a delay in setting up a higher damage potential to finally challenge folks that attempt to dive you. Also not a fan of the heal change, but it's fine, it's just me needing to adapt. Turrets were beforehand already easy to burst so reducing their HP by 40% is just ridiculous, forces a more spread-out nature and even then, if the enemy is there, they pop the turrets insanely quickly.2
u/El_Gran_OsitoAs a turret spammer I love it, wall refresh wall is fun.1
u/NoContribution4441imho she's way more fun to play now and way more annoying to play against. had a game with 75k souls, 95k damage (turrets+ult, ascendant 1) edit: echo shard on wall goes crazy1
u/Present_Dimension619Horrified at the medicinal specter nerfs. Turret life - very sad. Glad to be able to get more turrets down, but kinda dumb if they just get insta-killed anyway.1
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25r/SpondylolisthesisI dont need surgery!!daninjaaa190%1458.8regenerative medicine2026-03-04↗
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u/Ok_Trip9238I hate to be the bearer of bad news but I dont think this is a complete fix. Im almost 23M and had spondy since 19 from running too much too fast without recovering or training properly. I did all the conservative pt and heard steroid injections are only for a few months of relief but if you continue pt even during that, it might help mitigate the effects when the steroid wears off. When the nerve is so compressed from a collapsed disc, there isnt much conservative movement to do without causing pain and you put more pressure on upper discs anyways while suffering with nerve damage. I had surgery almost 5 months ago and i am the happiest and painfree ive been in years. Not saying its a death sentence and you should try to avoid surgery but i rather have 15-20 years of happiness before going through that pain all over again4
u/BuckityBuckYou can’t do steroid injections very often without causing damage, but if your doctor expects it to be a one time thing, that’s great.3
u/Agile-Development-88That is amazing news! So happy for you. You’re giving me hope. As a fellow almond mom of a daughter with grade two spondy may I ask the name of your doctor?! I’m desperate to keep my daughter from needing surgery.2
u/Similar_Blackberry29that’s amazing for you but i’m curious how you know it’s a one time injection? don’t these last like 6 weeks to a few months?2
u/NJcovidvaccinetipsSuper happy for you op. Similar situation and shot didn’t do shit for me. PT is definitely helping to build strength and reduce pain. We’ve gone from living in absolute hell to feeling bad which is a step in the right direction2
u/omsy828Which scans showed your bursitis? Glad to hear you’re doing better and I hope it lasts.1
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26r/tresslessPelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Pr...New_Stable8642270%657.6regenerative medicine2026-03-26↗
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u/RedAsh521Nothing is mentioned about presenting specific data from the trials
 thinking they will just say “here’s how our product works, it had significant effects” and nothing new or outstanding.15
u/Hotrock21Someone posted this days ago. What people are doubting is that Pelage won’t have the peachy data everyone hopes they do.12
u/Dry_Bunch_1105Live stream that shit!3
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27r/transhumanismIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz50%4857.1regenerative medicine2026-03-10↗
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u/Salty_Country6835The scenario assumes aging is the main thing regulating population, but that's only one source of death. Even if aging were cured, people would still die from disease, accidents, violence, and environmental risks. Life extension doesn't equal true immortality. If aging disappeared tomorrow but accidents and disease still existed, how different would life expectancy actually be? It also assumes governments could realistically ban reproduction. Humans don't reproduce through a centralized system you can switch off. Even very powerful states struggle to control fertility today. The other missing piece is demographic transition. Wealthy, technologically advanced societies already trend toward lower birth rates on their own. Historically when technology changes reproduction or lifespan, do societies ban behavior or adapt around it? More likely we redefine what "human" means before we ever reach stable immortality. Life extension, biotech, artificial gestation, and maybe even off-world settlement would reshape the system long before reproduction bans become the main lever. Would the real shift be population pressure, or the definition of human life itself? If life extension arrives gradually instead of instantly, what demographic pattern do you actually expect to emerge?16
u/Azure_ProvidenceAccidents and disease still exist. Some people will still refuse the treatments. People will still die so the real question is how much of a difference between the new birth and death rate be? People were afraid of overpopulation for decades but it turns out once people have a decent standard of living the birth rate naturally drops. It is entirely possible immortal couples will choose to not have children at all or stop at some small number that happens to meet the replacement rate. People in poor countries reproduce in high numbers due to lack of birth control access. Poor families in subsistence farming conditions also need more kids as a workforce. If these issues were solved families would shrink.5
u/TonightSpiritual3191Everyone saying it’s not going to happen by 2050 might be delusional. Truth is we’ve entered a new reality and no one knows where this is going to lead and how fast or slow adoption will be. If I had to give a prediction I’d say we might see people moving to more remote areas and maybe even the moon or in orbit. I think overpopulation isn’t a problem but people might choose to delay having children if their biological clocks are extended5
u/antii79By 2050? Reminds me of "women having sex with robots only by 2025". We're nowhere near close to that5
u/mikasaxoNo. People are still going to continue dying for hundreds of years even if aging is somehow solved. Diseases, accidents, war, and just the fact we don’t have equality of treatment2
u/medved76Humans are already naturally solving the problem of population growth.2
u/marilynjaynaIf we cure aging then people will be fertile for longer and will delay having children. That will severely decrease the # of kids over time naturally and without govt intervention.2
u/Users5252People would simply reproduce less2
u/HitandMiss28It’s almost like you’d be happy and relieved to realize there’s a god at this point.1
u/Useful_Calendar_6274no unless values change radically. people will still die from other causes, mainly infections1
u/golddragon88With decreases in the infertility rate exceeding all predictions. Stopping aging might be a necessary action just to keep the species alive. So no I doubt they'll doubt ban reproduction.1
u/JollyApplication6627Depends on the death rate. Immortal doesn’t mean invincible, as in, if you were immune to aging, jumping face first into a woodchipper would still kill you.1
u/SargeMaximusGovernments have held humanity back for so long1
u/Trash_Princess__This would be why space travel is so important. We would be able to spread throughout the universe rather than destroying earth.1
u/Pasta-hoboImpossible. All you need to reproduce are two default humans of opposite sex. The realistic approach would be to maximize research for 100% effective birth control. If you can't stop people from making more people, you can at least make sure the majority of people born are born on purpose.1
u/CryptoFourGamesDrugs and violence would likely remain as population control. Besides that, space colonization. Population only remains a problem in a world where we're not colonizing space1
u/NVincarnateNo. People would select for not having children naturally as intelligence and life expectancy increase as a result of global technological advancement and living conditions decline. Nobody wants to bring children into this trash fire of a world as it is. Why would population increase out of control?1
u/In_the_year_3535We can't simultaneously complain about low birth rates and an aging workforce and a fountain of youth. As for our minds handling it memory is kind of like the harmonic series were age 4 is 1 year, age 5 counts for 1/2 since you have 2 years (4 and 5), 6 counts as 1/3 (4,5, and 6) and so on. The harmonic series doesn't converge, we'll never run out (1000 will be roughly 1/1000th) but will always be heavily influenced by our earlier years.1
u/Different_Guess_2061We'll have artificial wombs and colonize Mars, so it won't matter: https://youtube.com/shorts/khurldIShF8?feature=share1
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u/dust_of_the_starsLet's put aside the very unlikely scenario that immortality will be available by 2050 and focus on more realistic problems. There are currently more than 8 billion people living on Earth, and the growth of population is exponential, even with falling birth rates. The space and resources on Earth are limited, and the nature destruction is catastrophic. Worry on how to deal with the real problems in 2050 rather than fearmongering about someone taking your rights for reproduction. Reproduction will not be banned but encouraged by the government because they need wage slaves and cannon fodder for wars, so don't worry about this part.
u/SeishominMinor semantic point but I'd argue that aging isn't a failure and removing it isn't a 'cure'. I appreciate this might simply be a philosophical position though.
u/-7-luckI just dont think they will soon, by 2050 much less. The idea that there's just "scientists" working around the clock on this. You understand you pretty much have to get a phd to meaningfully work in this field? That itself takes years and years. Who is sacrificing their own life to make others' lives longer?-2
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28r/sesamoidHope for thySuccessful_Lime_1349150%1056.8regenerative medicine2026-03-06↗
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u/Distinct_Audience_41Thanks for your story and healing journey!3
u/Successful_Lime_1349Also I do credit a large part of my healing to doing the BMAC injections. It was pricey but worth it.2
u/No_Ingenuity4846Yo just wanted to say I was in the same boat. I even made a post about it a few months ago. I had a hairline fracture that I spent months healing and even as I ramped up running volume the pain was only at a 1-2 out of 10 but I was convinced when I got my MRI it was going to show something was still going on. Came back completely clean. (Of course now I'm having sesamoiditis in my other foot but that's a different story.)2
u/neuranxietyCurious about how you feel your climbing shoes contributed to the injury - how much were you downsizing? Or do you think it was more of a fit issue? I first noticed my sesamoid pain after a rock climbing trip and I've become increasingly convinced that the shoes I wore on that trip were a huge part of the issue. Slightly too narrow in the toe box, but mostly they were just really soft and not supportive enough for my use case (high volume of tall single-pitch lead routes over several days). Have you started climbing again since you got the good news?2
u/Automatic_Victory682THIS!1
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29r/mdphdStrong MSTP BME/BioE Programs?Temporary_Shirt_1986140%1056.5regenerative medicine2026-03-08↗
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u/Novel_Hurry_4282in addition to the three you mentioned... blue chip programs: harvard-hst/MIT, Stanford, Duke, hopkins, UCSF-Berkeley, UW "under the radar": Michigan, CWRU, UCSD, Baylor-Rice, Pitt-CMU15
u/FicrabTexas A&M is not typically thought of as having a top-tier MD/PhD program, however BME is probably the sole area where they might outshine other programs. The director herself has a strong BME background, though it looks like she's pivoted to more infectious disease focused work. Be advised though that any programs in Texas go through their own medical school application system, separate from the rest of the U.S.7
u/Zakky121Hopkins has a pretty strong program too, I’m honestly looking for the same so would love to exchange tips/info with another 👍🏿5
u/Turbulent-Alfalfa-40If you are a ok with a MS instead of a PhD, check out ASU. Also Indiana have a partnership with Purdue I think3
u/A_Genetic_TreeHow has no one said Carle Illinois College of Medicine yet. They are engineering focused in general and md PhD program2
u/BagAway572More under the radar programs: UIC, UMaryland (with UMD in College Park), Alabama, Indiana (with Purdue), OSU, Wisconsin2
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30r/CervicalinstabilityCervical_Instability Post by Moderator against RegenexxProof_Draft4420110%1356.2regenerative medicine2026-03-03↗
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u/EmhillyI’ve worked in clinical research for years and I find it incredibly hard to believe Centeno wouldn’t at least be doing retrospective chart reviews and publishing results if results were statistically significant. Publishing peer reviewed studies would even be great for his marketing and for obtaining FDA approval or EUA. I find it very strange
13
u/kpt85Anecdotal experience does not mean something is common. That’s great your daughter has improved, I hope there are many more experiences like this. From what I’ve seen, most of the criticism sent towards Regenexx has to do with the way they advertise their services, the process they use, and the lack of willingness to adhere to basic research standards to actually move the science forward as opposed to gatekeeping all of it and releasing whatever information serves his purpose. From my limited interactions with Centeno I find him wildly unprofessional, but I hope he or anyone else can help more suffering patients in a way that is more widely successful, more transparent, and doesn’t require liquidating your retirement.9
u/JewaldHey proof_draft, thanks for the shout, hope you are well. I strive to be fair and open-minded, though I'll admit I'm not always perfect, that's for sure! The first link, iPSCell.com, is a blog by Dr. Paul Knoepfler, professor at UC Davis and a stem cell scientist. https://health.ucdavis.edu/cellbio/faculty/knoepfler/ Don't know him personally, but seems like a great guy, and his website is a good resource for patients considering stem cells or other regen med stuff. Stellar resource for patients. Hopefully we have a good treatment, potentially cure one day, and both this sub and mine ( r/cervical_instability ) become useless. That will be a good day. Until then, hope everybody is hanging in there. It's not an easy condition.... I live it everyday myself have for many years. I'll catch you another time✌6
u/dudeunkiwn_ffhOh they both him and centeno got beef. I get both sides though5
u/dudeunkiwn_ffhYup Kaiser tends to do that. Who was the doctor was it Dr.Hung or Kim. They are asses tbh3
u/Agreeable_Muscle_279They have some history lol2
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31r/DandysWorld_RobloxCRAVEN! [MASTERPOST!foxyfan37_1987120%955.4regenerative medicine2026-03-24↗
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u/ExtentDue2588Could be good but also has a very high skill floor, maybe make the debuff just very minor (level 1) and make the potency buff only like 50%3
u/No_Treacle5533Does he have an indicator?2
u/PossibleMammoth5639When I see the word "masterpost" I glitter in fun1
u/theultimatetheifgigiGrace and Dandys world colab going brr1
u/MiludayooI'm sorry but at first I got reminded of this fella <image>1
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32r/pennystocksUpcoming penny stock catalysts for Q1/Q2 2026 in Biotech and PharmaAvish_Golakiya1020%4855.2regenerative medicine2026-03-10↗
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u/J0hnnyBlazer22
u/BasilWithWaterRCKT let's go!9
u/Avish_GolakiyaNot promoting this at all, just sharing my take since I’ve got an avg around $3.2 RCKT (KRESLADI) PDUFA Mar 28, now stock is around $5.24. Probably the cleanest high PoA setup on the calendar right now. Gene therapy for LAD-I, and it’s already doing that quiet, steady grind up. No crazy hype yet, just slowly building. 76% PoA is pretty strong, and these names often get front-run when the risk/reward looks this clean.9
u/Likes_The_ScotchWaiting for ELTP the swing back upward. It’s been floating around $.40 for too long now. Anywhere but up6
u/North_Welcome_3249Glad to see ATAI on there.5
u/thepoisonpoodleHow is PoA derived?4
u/Stitch426Avish, is there any update on MDAI? They submitted for FDA approval June 20253
u/RandyMarshFundYou are missing IronWood Pharmaceuticals2
u/Business_Mixture_139Srxh??? Reverse merger coming soon1
u/Competitive_Nail_159bhvn stock1
u/Get_rch_or_try_dyinThanks ! I bought a pile of RCKT the last few weeks. I’ve also got a large pile of IMRX . I think it has some huge potential through 2026 !1
u/MainDark3321No love for LPCN and their phase 3 PPD data readout coming in early April. They clarified that timeline in yesterday's press release for their annual report.1
u/Shot_Truth_5701Geovax GOVX- Bought in after last capital raise recently. Worth a look. <image>1
u/GreenSouth3SRXH1
u/OldTeaching8407Put this in a ETf basket would be dope1
u/StretchMinuteBREAKING: Check out SCNX-- on fire today. Just the beginning!1
u/iamWfdupWhat's the status on ALMS, and PVLA?1
u/Ordinary-Evening552Aldx high chances of approval today.1
u/darkknight-6Thanks for sharing. What are your thoughts on ALDX?1
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u/turnleftorrightblockTy.
u/Affectionate_Strain6INTS-1
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33r/Podiatry"Regenerative Medicine" in PodiatryOldPod7320%8354.9regenerative medicine2026-03-19↗
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u/darken909I use PRP a lot in my practice. I see great results from it. SportVisc is getting popular in my area, a lot of sport med docs use it.12
u/SaltRharrisPodiatrist hate each other, in real life and online.12
u/Dramatic-Sock3737Glad you are amused. My brother does stem cells and PRP as a pain mgmt doc. Without him I would have needed rotator cuff sx. I have no problem with pods or other docs performing care that isn’t covered by insurance if they find it’s helping their patients.9
u/Dramatic-Sock3737You do you. Please don’t tell me or others how we should practice.9
u/1stMPJFuserIts the Cashification of medicine. Everything has to be treated with something special that costs $500+. They other day a patient came to me with an arthritic valgus ankle - they paid $3K for stems cells to a chiropractor. Did nothing. Another patient came in with bread and butter Achilles tendonitis. The problem was they were told it was torn, it wasn't, and that they'd need to start with $800 of shockwave. I wonder sometimes how doctors get patients to agree to these things, but now I know the answer. You offer nothing else. Its expensive treatment or cya. I think its tough to be a patient.8
u/ShiyuanDPMI’ll stick to my Tolcylen and low-dye strapping thank you very much. 😁6
u/azalin77I think the problem here is your passive aggressiveness ending your original post with snakes oil salesmen. I also highly doubt you "know" much about PRP or regenerative medicine because if you did, you would know it works. I'm one of the actual pioneers in this field as far as podiatry goes in NYC and can assure you it mostly works but you have to understand the pharmacologic and pathophysiological science of why you're using it and what you're using it for. I've used it extensively for nearly 25 years now both in the O.R. and in the office including BMAC/PRP/PPP/amnion/A2M as mono therapy and also in conjunction with HA injections and can assure you I have a 90+% success rate with it. Like anything else, though, it's not for everybody or every issue and I think that's the issue - when it's being marketed to patients to make a buck without understanding the biology behind it.6
u/DrTFPIt's all BS The key to success is taking stupid people's money legally4
u/Living-Protection250I get the frustration. There’s definitely a lot of noise around it right now. I think the tricky part is separating what’s promising vs what’s being marketed ahead of the evidence. Some patients are willing to pay for that “last option,” but the expectations and informed consent piece really matter. The business model shift is interesting too, but I agree it doesn’t automatically validate the treatment itself.2
u/Low-Conference-3762Anybody use PRF?1
u/OldPod73Another thing I find utterly amusing is that if I mention a statistic or number on this Sub, I get DESTROYED with "Where did you get those numbers!!???" Yet, no one is challenging anyone on here to present the numbers from a source other than themselves. It's hilariously ridiculous to me. Talk about confirmation bias...1
u/Critical-Ear-2478I have seen a lot of great results with other modalities that are not typically covered by insurance. Shockwave therapy, laser therapy, etc. PRP and amniotic injections are other great modalities, but I do not use those in my office. I think there is a place for anything.1
u/healthyfeetpodiatryI offer it but not as a first-line therapy. When you've done everything conservatively for certain issues, it's a great option before doing surgery which a lot of ppl don't want1
u/DrValentineDPMThis is such a great topic! I practice in Louisiana and I often use PRP for 2 key treatment protocols For plantar fasciitis I use a TOPAZ wand and then inject PRP after. It works very well. I no longer do EPFs. I use PRP as a treatment adjunct not as a sole line of treatment. This procedure is always done in the OR. So I bill insurance and not the patient directly. I do a similar procedure for Achilles tendonitis. I use the TOPAZ wand first then inject PRP after. - This has been a game changer. We all know how hard Achilles tendonitis is to treat! I hope this gives you some insight. You can definitely charge patient’s for PRP. Regardless of the science there is enough anecdotal information to support its usefulness. How you market is up to you 😉 Best, Dr. Valentine DPM- Foot and Ankle Specialist1
u/StewoveritNot sure what the point of this post is other than to troll. The minimal amount of counter evidence you provided in a comment can easily be rebutted by a quick Google search for articles that state the exact opposite. If you don't believe in it, don't do it. I don't provide these services simply because it wouldn't be worth it with my patient load. I'm curious as to why you consider yourself an expert in this area more than the countless practitioners who advocate and utilize these methods?1
u/SaintBobby_BarbarianLate to the party but PRP whether for injections or for wounds is a great tool with plenty of data backing it up. And organogenesis is getting a BLA approval done for osteoarthritis, with promising results. Then you also have stuff like shockwave therapy as another therapy option that has both reimbursable and cash pay options. Can you build a practice only on that? Not likely, but it’s another great segment to have
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34r/DDDInvestorsDDD x United Therapeutics: 3 Hours Ago on LinkedIn
 They Just Pulled the “Moonsh...Imaginary_Weight6488120%754.6regenerative medicine2026-03-07↗
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u/PuckeringHole15k shares accumulated over the last two years with an average of around $2.30. I load under $3 because I believe in the tech, specifically this company, and I want to make a million dollars.3
u/ReactionOk9053Posts like this help build the narrative, but until an IND is filed it’s just talk.2
u/NoLengthiness3126Let’s start developing them! They might even be able to be delivered right to our front door like all the other Amazon items. âœŒđŸŒđŸ‘€1
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35r/DeadlockTheGameHero concept - TONIC - suppport hero with a chemist themebaldiplays100%854.3regenerative medicine2026-03-30↗
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u/1GameBoyMasterSo do the stacks disappear once you use your ult, or does it stay like Mina's ult with her bats?1
u/confidentlyfishПОНОС1
u/Usual-Lynx2362Honestly I think the roster could really use veteran/WW1/Government characters other than Haze and potentially Warden, whatever they do with him. Also could use more off-supports like Doorman. I think it'd be neat, like Ana from Overwatch able to boost allies and enemies with precision shots. Also remove Graves
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36r/STEW_ScTecEngWorldNewfound third cell type enables fully functional hair follicles in the labZee2A460%154.1regenerative medicine2026-03-05↗
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u/ZestycloseTowel2493Amazon link?2
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37r/4tran4One day, through science, my voice will be returned to me.New4taccount90%853.8regenerative medicine2026-03-08↗
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u/ufstdidkyjryrand how do you picture that happening1
u/Intelligent-Tea-2058FemLar VFS worked great for me. I'm starting to be able to sing again. I think I can get there pretty fully with more post-op voice training. Some of my friends got it recently, we'll see how they do... but I am hopeful. https://m.youtube.com/watch?v=75jKDGMW9-w It's much more extensive than other VFS methods. Basically "airway SRS." I really want to see it spread and developed more.1
u/hotobamasexLaryngeal framework surgery?1
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38r/HubermanLabLongevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran130%453.2regenerative medicine2026-03-22↗
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u/BioMIR_1221Try BioMIR app from the app store for daily computation of biological age based on 15+ biomarker inputs from wearables and home-based devices. It also computes KDM and Levine phenoAge based on episodic clinical bloodwork. We can’t modify what we can’t measure. Lifestyle prescription without observability is mere opinion. Self-experimentation begins with proper instrumentation.1
u/midnight-on-the-sunI was just diagnosed with borderline LPa, 85 and PTau, 2 points over normal. No disease in family history. Genetic high hdl.1
u/That_random_momQuest Labs uses the following on APOB, are you suggesting it should be lower than the recommended guidelines from my lab? I am APOB 3/4 with a result of 86. Currently have lowered my LDL 30 points with lifestyle interventions and still on the downward trend.  "APOLIPOPROTEIN B Unit of Measure: mg/dL 86 Reference Range: <90 Risk Category: Optimal <90 Moderate 90-129 High > or = 130 A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient including patients on lipid lowering therapies, patients with ASCVD, diabetes with >1 risk factors, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020."1
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39r/ApoE4Longevity doctor (APOE4 carrier himself) shares his exact ApoB targets, statin p...DrKevinTran140%352.5regenerative medicine2026-03-22↗
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u/eddyg987Resovastatin does cross the bbb. ApoA1 can cross the bbb and can integrate itself onto an ldl particles thus making it them less dysfunctional. So hdl does matter for apoe4 carriers further evidence of this is the data from the ocetrapib phase 2 study that showed 20% less plaque formation. They(the authors of the study) claim direct obecetrapib interaction, but that’s wrong it’s the huge increase in apo a1 caused by the cetp inhibition.3
u/CantaloupeNo3975Is this the study referenced? If so, it looks like the participants with HMGCR SNPs had an average blood ldl of around 130mg/dl. Am I reading this correctly?1
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40r/NightLordsUpdate to my warbandJohn_Maynor_1380%652.4regenerative medicine2026-03-20↗
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u/Ok-Food-7548I don’t know much about NL but I like it2
u/lsdjowThis is really cool , do you have any kitbashed models for them yet?2
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41r/HFY[The Lord of Silvershade] - Chapter 7: Point BlankZinthorr50%851.3regenerative medicine2026-04-01↗
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u/Zinthorr02:00 PM - The First Lift Noah consumed a piece of Mana-Sage tea to keep himself upright. He focused on the trench. He pulled the earth upward, flowing it into the space he'd cleared. Because he was Level 7, the earth felt more like clay in his hands, more responsive. [MANA: 100 -> 10] (Regen included) Slowly, a new wall began to rise. It wasn’t 10 feet yet, it was a 3-foot-high, thick, dark-grey "stub" that traced the 70x70 line. It looked like a scar across the forest floor. 05:00 PM - The Exposed Bailey Noah was physically and magically exhausted. The 30x30 inner fort stood behind him, safe and spiked. But he was now standing in the "Bailey", the 20-foot wide gap between the old wall and the new, unfinished one. "Noah," Cortana warned. "You are at 10 Mana. The new wall is only a low barricade. If the Bear was still alive, he'd step over this without slowing down. We are officially in the 'Danger Zone' of construction." Annastasia stood at the inner gate, leaning on her new Cold Steel Longsword. She looked out at the deepening shadows of the forest. The violet light was fading into a murky indigo. "The forest feels our work, Noah," she said, her voice low and warrior-sharp. "The birds have gone silent. Something is watching the new line." Miya was up in the Sentinel Spire, her eyes darting across the landscape. "I see eyes!" she called down. "Small ones. Many of them. Not bears... Skulkers. They know you are drained." [DAY 14 PROGRESS] Foundation: 100% Complete. Wall Height: 3ft / 10ft. Mana: 12 / 200. The Evening Crisis: The pack of Skulkers, perhaps twenty of them, led by a larger Alpha, circled the new 70x70 perimeter. They hadn't crossed the 3-foot "stub" wall yet, but they were testing it. "Everyone, back to the Citadel! Move!" Noah didn't wait to see if they followed. He grabbed Nugget by his scruff, ignoring his indignant chitter, and ushered Miya and Anna through the gap in the inner 30x30 spike-wall. Anna moved with a grim, focused efficiency, her hand tight on the hilt of the Cold Steel longsword. Once everyone was inside, Noah slid the heavy Ironbark-reinforced earth slab shut. Clack-thud. The Citadel was sealed. They were safe behind six feet of petrified earth and a forest of Ironbark spikes. "Miya, watch the gate. Anna, stay near the lodge," Noah commanded, his voice raspy from the day's labor. He scrambled up the spiral stairs of the Sentinel Spire. His legs felt like lead, and his vision swam with the "Mana-Ache," but as he reached the top and rested the Savage Axis on the parapet, the world narrowed down to the crosshairs. Outside, the Skulkers had crossed the 3-foot "stub" wall. They were in his Bailey, sniffing at the freshly turned soil of the garden and the iron ore in the pit. The Alpha, a lean, scarred beast the size of a mountain lion, stood atop the pile of iron ore, letting out a series of sharp, clicking barks. It was a call to the pack to begin the feast. "Target locked," Cortana whispered. "Distance: 25 yards. High angle. Noah, you're shaking. Take a breath. Hold it. Squeeze." CRACK-BOOM. The .308 muzzle flash lit up the twilight. The bullet caught a Skulker right as it was about to bite into a zucchini vine. The creature was tossed backward, its chest cavity collapsing from the impact of the soft-point round. The pack froze. They looked at their fallen comrade, then up at the tower. CRACK-BOOM. The second shot took another Skulker near the well. It didn't even scream; it just dropped into the mud. The Alpha snarled, its hackles rising. It looked up at him, baring its needle-like teeth. It seemed to be weighing its hunger against the "Lightning-Staff" in the tower. Noah lined up the vertical line of the reticle right between its glowing amber eyes. He didn't fire. He just waited. "Psychological warfare, Noah," Cortana said. "Let him feel the scope on his brain." The Alpha blinked. It let out a frustrated, low-frequency hiss and turned, leaping back over the 3-foot outer wall into the safety of the deep violet ferns. The rest of the pack followed suit, a chaotic scramble of grey fur and clicking tails. [THREAT NEUTRALIZED: PACK DISPERSED] [XP GAINED: 60] [LEVEL 7: 610/800 XP] [AMMO CHECK: 29 ROUNDS REMAINING] Status: Mana: 15 / 200 (Regenerating). Stamina: 15 / 210 (Severely Exhausted). Balance: $345.00. Noah let out a long, shaky breath and leaned his forehead against the cold earth of the battlement. "That should keep them at bay for the night," Cortana said. "But they'll be back. They saw the 'weakness' of the outer line. We need to finish that wall tomorrow, Noah. No more distractions." He climbed down the stairs. Miya was waiting at the bottom, looking up at him with a mix of concern and admiration. "The lightning spoke," she said softly. "The garden is safe. For tonight." Anna was sitting on the porch of the lodge, the Cold Steel blade resting across her lap. She looked at the rifle in his hand. "A warrior who can strike from the he4
u/HFYWaffle/u/Zinthorr has posted 6 other stories, including: [The Lord of Silvershade] - Chapter 6: The Broken Blade [The Lord of Silvershade] - Chapter 5: Roots in the Violet Clay [The Lord of Silvershade] - Chapter 4: Foundations [The Lord of Silvershade] - Chapter 3: The Spark and the Steel [The Lord of Silvershade] - Chapter 2: Building the Lighthouse [The Lord of Silvershade] - Chapter 1: Four Hundred Square Feet of Order This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.1
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u/GumGodGamingGood part well done Wordsmith You may want to pin the comment part so it stays at the top (I think Reddit lets you do that?) ... with sort by best on the bots are before it1
u/GrimkytelYou've got a couple repeated paragraphs in the Day 14 Agenda section. Looks like you were correcting/ tweaking and didn't clean things up correctly.1
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42r/TrenchCrusadeBuilding my first warbandMurky_Reception_553440%950.7regenerative medicine2026-03-23↗
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u/Random_Guy_BenStandard game size is usually 800/6 or 900/8. However for your first few games i would recommend to start with 700/0.4
u/KallandrasWelcome to the hobby. Seing that you are an absolute beginner, I wanted to drop some advice on listbuilding in general before talking about sultanate and your list. You can also always ignore good listbuilding and just play models that you think is cool, but then you should really not ask around what you should play but ask only yourself and play what you like. But if you want to build effective warbands, here is some basic advice: More units, more good: In all but one subfaction, more units are better and it is universally accepted to use the campaign unit limts as the maximum that is allowed (10 units at 700 ducats and +1 for each additional 100 ducats, glory does not matter). Especially at higher points, so starting 900 and some glory or at least 1000 it should be possible to hit that unit limit. The reason is that it is terrible to pass when your enemy still has 4 units left and can do stuff without you interceding. That also often means that you have to activate your good units before the enemies juicy targets are out of cover and you waste their activation. On top trench cursade is a game about objectives, so you want to spread and have enough units to sit on those while other units try to kill the enemy. To translate this to listbuilding, you want some powerfull elites or mid tier units and fill up with models that are as cheap as possible while still having the chance to do something (wretched and prisoners are fine if they just exist without being able to do more then sit on objectives, they are that cheap). Gear your units so that whatever they do, its done at least at +0 dice, +1 if possible, never at -1. So dont give models with negative ranged stats good ranged weapons. As ranged attacks are most often made vs. cover and often at long range, most of the time you will have a -1 or -2 modifier to your ranged attacks, so even on a +1range model, you really want a ranged weapon that ignores cover, long range malus or gives you +1 to range, more so on a +0 range model. This is why bolt action rifles are not good on +0 range models if you can use a shotgun or a grenade instead. The rifle has more range, but you will not hit anything above 12 inches and below that the other weapons are better. It is also a waste to give a second melee weapon to a +0 melee stat model most of the time. Dont just think about how good your melee and short range units are if the connect, also think about how they can make it to the enemy in the first place. Especially melee units need to dash to make it to melee unless the enemy randomly pops up within 12 inches of you and does not hit you first. So normal 6 inches movement models without a dash bonus that just want to go melee are normally bad, would need to be outrageously tanky and hit hard to make them good. Similiar for very short ranged ranged units. Infiltration can make up for those short range units, as they can use their normal move to move into shooting range, melee units have to use their dash to move into charging range (which is a risky action so you pass your turn 42% of the time). A musical instrument is the best equipment in the game, it goes in every warband. Dash is the most important thing you do in trench crusade. It is basically required for melee untis, but its also amazing to move, shoot and dash back out of sight or simply to take objectives or shoot and dash out of melee range. Every melee unit should have a ranged assault weapon unless they have negative ranged stats. That often is a grenade. 95% of models with a ranged weapon do not need a grenade on top, only if your range weapon does not have assault and your main gameplan is melee (or the grenade is a satchel charge). You need armor breaking weapons, relying on bloodbaths to break armor is not as effective. So bring some solutions here. Starting at -2 armor, normal attacks will not cut it to kill within a reasonable time. Helmets, gas masks and so on are only worth it on tough and highly armored units. The reason is that unarmored units will die with or without the additional blood, so gearing them with an item that is inherently situational is bad. Its always better to stack defences on one model. About sultanate, currently they suck hard, only the house of wisdom is a little ray of hope. One reason is that they dont have good weapons for their elites and since the 1.0 rules changes, ranged based armies in general got weaker as you do not gain +1 to injury on downed models at range anymore, which is very significant for bloodbaths. However, (non scatter) blast and automatic ranged weapons got huge buffs and sultanate just does not have those or no good carriers. Their theme is single target ranged weapons (jezzails) and those are outperformed by grenades and their siege jezzail is too expensive. House of wisdom however can steal actually good weapons from other factions and have the one model where MURAD bombards are actually good on, the homunculus (bull has too low of a ranged sta4
u/OpIvy1137For your first game, I always recommend starting small. 700 ducats is the biggest game size I ever recommend for first games, and even say that 500 is better. The smaller the list the easier it is and generally less complex your list will be, so you can focus on learning/mastering the base rules of the game and less on the thousand individual rules of each piece of battlekit. An easy way to make a starter list is to just use the models that come in the starter warband bundles. Then give them some decent equipment, and boom basic list at 700 ducats. Also looking at your list real quick, I just wanted to note that unless you and your opponent agree ahead of time, you cannot bring trench dogs or any of the campaign glory items to a one off game. They are campaign specific. It's a new change to trench crusade, and some people miss that rule.1
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43r/FuturologyIf humans cure aging by 2050, would governments eventually have to ban reproduct...hosseinz0%4549.9regenerative medicine2026-03-10↗
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u/kore_nametooshortIf aging ended, we would continue to die due to disease and accident. I vaguely remember reading a study that said average life expectancy in the western world would be about 1200 if that happened, but it would be more like a half life where you'd expect half the population to die in that period rather than people to live about that long, give or take. So reproduction would be necessary, but to a much lesser degree. This would probably lead to restrictions, but not bans. Something like a stricter version of the China one child policy, or severe devaluation of human life allowing countries like russia to throw lives away in wars much more readily. It might also coincide with higher productivity because you would change from having only about 62% of the population being working age to probably the high 90%s. And many fewer of those dedicated to caring, education for the very old or young. You would need this to bring in more food, energy and housing for all the people.17
u/CTRexPopeThey likely won’t need too. Birth rates are already falling globally. Give people time to put off kids for decades if not centuries, enough will opt in and die from random accidents to control the population level.9
u/malk600Cool, cool. Let's start with the obvious. We're not going to "cure aging", and certainly not within 20 years. People who claim that are misinformed or selling you fancy snake oil. Long term? Who the hell knows. I kind of like to imagine a Star Trek or Lancer-like future (or even Expanse, though that's not exactly optimistic), where space is the frontier that calls for humanity to fill it, but the path from here to there is fraught at best.6
u/orgin_orgAny such cure would probably entail obscenely expensive RNA treatments that are specifically tailored to an individuals own DNA and cellular makeup and not a generic treatment that works out of the box on anyone. So only very rich people would be able to afford it. That is, the adoption would be very slow so any population regulation would be very far down the line.5
u/GerdioneI think quite simply no. If the only part of your hypothetical is that they cure aging, then it just means that only the obscenely extremely wealthy and connected will have access to it thereby cementing their legacies and power. Why would they make it accessible to poor people? Insurance already tries to cover nothing, imagine arguing why you need to stop biologically aging.5
u/WaboritafanThere is a Kurt Vonnegut story that tackles this subject. A man and his wife have triplets on the way. They must find 3 people willing to die voluntarily so the babies can live. Or the babies will be euthanized.3
u/Aggressive-Fee5306"Fill out a C-01 permit before engaging in any activity that may lead to reproduction." Doubt it though, to governments it means more taxpayers and to businesses cheaper labour. There is no concept of "okay, 100 billion is enough"2
u/IndigoFenixYou're forgetting about the cost of raising a child. Populations don't grow without limit, they are restricted by the available resources, which is abstracted as money. If immortality becomes cheap and available, what is most likely to happen is that the paradigm of "once a child is born, someone has to support them" will fall out of favor, and that the cost of supporting a child will fall on the parents. If parents have more children than they can afford, those children will simply die. It seems cruel, but what's the alternative - artificially preventing most people from having access to immortality treatment? That's the same as letting everyone die when they don't need to. Try that, and you've turned the minority restricting the supply into a target for literally everyone else. Provide easy access to both birth control AND cheap immortality, and people who decide in spite of this to have children they can't afford will become the target instead. That's a minority that is much easier to condemn.2
u/fafarexIt raises some strange questions: Would reproduction become illegal in an immortal society? moot point it would never be available to enough of the population for it to need this type of legislation. Would immortality create a permanent ruling class? most likely an indirect one based on oligarchy in democratic country and an actual one in dictatorship an monarchy. Could the human mind even handle living for centuries? since we are talking about a case where your brain regenerate permanently (a requierement for extended life/immortality) at worst you should forget things very far in the past that you didn't thought about for a long time, just like you already do now.2
u/leigen_zeroLike you said it will be a luxury product available to only the ultra-rich. Rest of us will grow wrinkly and frail like we have done since ape first picked up a rock and smashed another ape in the head with it. The immortals will stand to make so much profit from the mortals that they'd never allow a deathless society.1
u/Low-Speaker-6670Love death and Robots episode "pop squad" Your fictional scenario played out.1
u/owjfaigs222Well seeing how the birth rates are going down in developed countries, perhaps people would stop reproducing on their own. But otherwise, if it's available to an average Joe, probably yes. Population control was already used in some countries like China.1
u/DragonWhsipererIf you want a glimpse on how that would work, you can check out the Warhammer 40k universe. It's a satirical hyper enhanced, highly advanced but very dark future of humanity, where all the darker sides of people and their motivations are magnified to the extreme. Class warfare exists where anyone who is part of a ruling class is always part of a dynasty that can get Rejuvenation treatments and live for centuries. The rest of humanity lives in terrible conditions, is allowed to propagate without restraints and any excess of the population is  used as cannon fodder for endless wars in service to those in power. So yeah, elites will hoard this undeath technology for themselves, while reaping the rewards of the rest of use for perpetuity.1
u/Leather_Office6166In a world with dense populations and no vaccines, protection against aging would be unimportant because almost everyone dies before getting old.1
u/dust_of_the_starsDon't worry. The system needs cheap slaves to perform the labor. As long as human workers are cheaper than robots, your right to produce new slaves will be encouraged. Robots that can do manual labor like cleaning and cooking are expensive and difficult to make, so there is still a long way until they become cheaper and more efficient than humans. Capitalism does not encourage space colonization or the development of innovative drugs anyway because the research required for that is risky and does not bring quick profit. I doubt there will be any meaningful progress made until 2050. So, the system will remain the same, and the population will continue growing exponentially until this planet is depleted of all the resources and pollution from wars, chemicals, plastic and factories reaches the levels not compatible with life. However, your reproduction rights are safe. Capitalism needs your children for labor.1
u/TrophallaxisCurrently, a fertility rate of around 2.2 is necessary to sustain a population. That's basically because everyone dies at some point - that's the 2 part, and some people die without having any kids - that's the .2 part. If no one died from old age, we would still need at least a 0.2 Fertility Rate just to compensate for random fatalities. Fertility rates are in free fall all across the globe. South Korea already has a fertility rate of 0.68. A lot of developed countries skirt around 1.2. And, mind you, all this with governments bending over backwards trying to incentivize big families, and people still facing a lot of pressure from their relatives and their biology. Like, I did a little poll among friends, obv. not representative, but I asked why did they have children at a certain age and not later or sooner. Every answer came down to some version of this: - not sooner because money - not later because then less chance for grandparents to be alive - not later because of biological limitations If we solve aging, all three factors change. You can keep building your life until you can have kids on your terms, spend as much time with them as you want, no compromise. Important family will still be around and your biology (perhaps with assist, but still) will still enable children. I am very much convinced that radical longevity will keep pushing down birth rates further.1
u/pjkm123987It won't be available or told to the public. Only private will ever know about it
u/StarChild413[deleted]
u/JUST_A_LITTLE_PUSHNaw. We'll send all the ageless Zombies to Mars instead. First we have to survive World War 3 before living World War Z.
u/wwarnoutif curing aging actually becomes possible, would it improve humanity, or create a dystopian future? I read a novel about an intelligent alien species that had conquered aging - and their society stagnated. Their people no longer had the pressure to "get x done before they die", and instead took the attitude, "I'll get around to it eventually...", and "eventually" never came.
u/texan-janakayIF all causes of death other than accidents were implemented (i.e. aging, cancer, etc.) we would definitely need to implement some sort of reproduction control. Hopefully people would at least put off spawning until they were older and more settled and could better afford it, instead of the welfare children we have now. In the world of sci-fi, they often solve this dilemma by making birth control implants (both sexes) mandatory at puberty. Then only when the person can prove financial security AND emotional maturity can the implant be removed. That has always seemed reasonable to me. Can't afford the baby? nope, can't have one (yet). Can't nurture it and take care of it? nope can't have one (yet).
u/Punpun86If it happens it will be a available only for the ultra rich. The rest of us useless eaters are not needed to be alive and "leech" the pension scam fund.-1
u/2mxm2If this can be solved, it will be available to the rich, not the poor. There will certainly be no interest in everyone being immortal and the number of people going to unbearable numbers.-2
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44r/HelldiversSome specializations and QoL upgrades I think could be fun. With 5 points, what ...Sebanimation60%348.9regenerative medicine2026-03-29↗
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u/MoschopsMeatballA Payday 2 akin skill system could be pretty neat if implemented right, Crew chief was a pretty cool perkdeck in Payday 2, Would be nice to see a sort of leader perk here too for people who want to support others passively2
u/Paul6965I am so glad we do not have a skill tree. As cool as it sounds... it just limits playstyle1
u/TNTBarracudaIf we're already limited in skill points, why also make options mutually exclusive? I'd think selecting two similar options would be more interesting, no?1
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45r/ReverseRhinoplastyThe demand for regenerative medicine in restoring the nose or ear anatomyhanginaroundthistown40%448.0regenerative medicine2026-03-19↗
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u/Massive_Classic8352You’re doing great work for spreading information about these issues1
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46r/EB2_NIWEB2 NIW Profile Review – Low citationssteampunkorange20%1048.0regenerative medicine2026-03-05↗
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u/Excellent_Elk_964I think your chance is really high, I’ve seen people who has little to zero citations were approved. Chen would find a way to make your work credible nationally. Is your work under Critical industry list?2
u/specific_account_It was approved with five citations in March 2025, PP, no RFEs.2
u/spiritofniterIf Chen offers approval or refund, then go use them.1
u/ratchetsistersSee my post1
u/Agreeable-Math-6560You have a solid profile. I don't think you will get RFEs. I hope you were more careful when you wrote your PE, explaining the national importance and benefits rather than limited to your center or lab. Best wishes!1
u/DesertFox0991Good profile to proceed... Best.1
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47r/FunctionalMedicineDr Robert Abraham Orlando: background in regenerative medicineSophistry730%547.5regenerative medicine2026-03-17↗
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u/OppositeSuccessful58This is actually super helpful . It’s always a bit of a red flag when search results are scattered, but seeing it framed as a career shift from direct care to consulting makes a lot more sense. Thanks for sharing1
u/Unable_Thanks_8614I haven’t worked with him directly, but that whole “healthcare strategy over just running a clinic” mindset actually makes a lot of sense, especially in a place like Florida. It’s definitely not the easy route since there’s a ton happening behind the scenes, but from what I’ve seen, that’s usually what leads to something more stable long term1
u/iliveformyshipsFrom what I’ve seen, he really puts a lot of focus on the operational side of patient care, not just the biologics part. It felt more about setting things up so the clinic could actually run smoothly on its own. During the early stages, he was pretty accessible if something came up, and even though he gave space to figure things out, he’d step in and help when things slowed down. That balance between strategy and real support is honestly not that common.1
u/Living-Protection250This is a solid summary. From what I’ve seen, profiles like this tend to look “scattered” because they sit at the intersection of clinical care and program-building rather than a single traditional role. The shift you pointed out from direct patient care into helping clinics implement regenerative or biologics-based services is actually pretty common, especially in pain and MSK spaces where clinics are trying to expand beyond standard rehab models. That usually involves a mix of operations, protocol development, and figuring out how to integrate newer modalities into existing workflows. One thing I’d be curious about, and maybe others here have insight on, is how much of that work is focused on clinical outcomes vs. helping clinics structure and deliver those programs sustainably. That tends to be where a lot of variability comes in. Appreciate you putting this together though, it’s helpful to see it laid out this clearly.1
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48r/premedWould high research hours make up for low undergrad GPA?ExcitingInflation61210%1947.1regenerative medicine2026-03-12↗
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u/Agitated_Depth_6881high mcat would high research? ehhhh, do u have pubs?21
u/cardiacpandano you should focus on your mcat8
u/ApathyisDeath_Usually, if one factor of your app is low you have to compensate by increasing other factors. However, other parts in your app are weighted more (they vary from school to school). But an all around rule is GPA and MCAT are the most important. I believe as long as you have a >3.2 gpa with an upward trend of 1 year or more then crushing the MCAT will definitely help (also assuming your LORs and EC are decent to good)4
u/KaiserWCNo. Having a very high MCAT will help somewhat. But once you get sub 3.4 your chances are iffy overall without grade repair. (This is for US MD. 3.3 with a good MCAT and research is good for DO)4
u/LopsidedCan4803My cGPA was sub 3.4, and my MCAT was around average for MD matriculants. I had a ton of clinical hours but, more importantly, an upward trend in my cGPA and some time between that bad stretch of grades and now.2
u/pre-healthAre you applying MD or MDPHD2
u/TLtomorrowNo, at least, not for MD. Schools really need to see you can handle med school, especially with Step1 pass rates sitting at around 90% in recent years. Unless there's a clear upward trend, you'll need a strong MCAT score (roughly 515+) to make up for it. Probably less so if you apply DO, but I'd still heavily prioritize the MCAT.2
u/BeneficialEscape3655No, focus on MCAT1
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49r/DogAdviceHelp I’m desperate to find similar case(s)Reasonable-Dark-425630%446.8regenerative medicine2026-03-13↗
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u/BulkyBug3197I see that she is on doxy. Are they empirically treating her with those for possible tickborne issues? As far as food, I would offer her anything under the sun to try and get her to eat. We would resort to canned cat food, beef flavored baby food, those little Vienna sausages, as alternatives. They also do make appetite stimulants for dogs.1
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50r/MauraMurraySubDoes anyone remember who the poster, “LowerSlowerDelaware” was? Before I even ca...Walla-bee150%4546.7regenerative medicine2026-03-07↗
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u/P_SheldonPage one: "if mr Murray was awake when Maura arrived at his motel..." Let discuss. I don't believe for a single second Fred was asleep when Maura arrived back at the Quality Inn Hadley Ma and then get this too, took her father's cell phone and called BR in the early morning of 02/08/04. BS IMO. So, Fred, just slept through it all? Sure. And Santa and the Easter Bunny are real.10
u/igraduatedI'm interested in what Beagle is saying in this post from 2011 above, I've never seen that particular post. Interesting. Like most I've certainly changed thoughts a lot. I still don't think she was at wbc at that time. Did someone kill her like they allegedly said and that story was repeated to jr? Or did they set up her abduction. I'll remind you I think she was abducted in Amherst and taken elsewhere, and the car went to Haverhill. What's up with Eastover? Very weird. But I do think Beagles thoughts on the biomedical fields especially around Springfield is very interesting. Highly2
u/Delicious-Werewolf54PM me ,when your time allows...Gotta discuss a detail2
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51r/ATHXGovernment subsidy for Healios' CDMO officially approvedimz7250%246.7regenerative medicine2026-03-27↗
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u/nova8188Read 1/2 way through this article and checkout over about production facility which has athxq name all over it.1
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52r/OsteoarthritisPRP for Degenerative Disc Disease and Cervical Spine Osteoarthritis?No-Papaya-982320%646.3regenerative medicine2026-03-12↗
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u/ButterscotchIll1523I used it for my knee. It was a game changer. I’d talk to your doctor and ask if you’re a good candidate. I read it’s most effective for stage 1-2, but it’s hit or miss for higher stages.2
u/No-Papaya-9823[deleted]2
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53r/gradadmissionsCincinnati Children's DSRM ProgramNew-Call-461220%646.3regenerative medicine2026-03-12↗
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u/tiredofmitosisCongrats! May I ask why you believe you are admitted? Did you get a call or something?. I am waiting for the immunology program at Cindy which shares many faculty with your program. I did an in person Interview last week and enjoyed it very much, even tho i admit that this place is less well known compared to many other schools. But i genuinely think they are strong at their stuff.1
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54r/biotechWhat are the prospects for an Individual after a Bs in biomedical science/ Ms in...undercover_arn_20%646.3regenerative medicine2026-03-04↗
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u/Outrageous_Duck3227bs biomed alone is pretty mid, you either end up in low paid lab tech work or pivot out after stressing for months. ms in something niche can help but only if you’re ready to chase phd, networking, maybe relocate. industry roles are limited and hiring is crap lately, job market sucks4
u/JayceAurYou should try to get some wetlab experience as well as you get your BS. This will help you land a job afterwards. MS is marginally useful, for now. Prospects are okay, market is rough, but hiring is still there. Don't bother trying to learn about the lay of the land from online forums. Mostly it's opposite extremes going off. Talk to mentors who can provide legitamite guidance. As I've always said, do something you're talented in. That way, there is always some corner you can shove yourself into in the field.2
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55r/tresslessWhy did Pelage present only phase 2a results?Acceptable_Phase62410%1446.1regenerative medicine2026-03-28↗
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u/otherwiseofficialThey will and weren't lying. Their CMO even already said they wouldn't present the phase II results on this conference, but this is tressless so everyone gets crazy excited over nothing.18
u/nanananana45someone else posted in another thread that there is no phase 2b and they went straight to phase 3 EDIT: The link you provided is a post to an announcement about series b financing, and it mentions Phase 2a and phase 3 trials, but there's no mention of phase 2b. I could not find anything via a google search where Pelage has ever said there was 2b study in process or planned, and it was only speculated by this site and other hair loss posters theyd be in phase 2b late last year11
u/trey_19833So I’m not really concerned at all by this, it’s pretty standard stuff for drug development. My problem is how everybody on Reddit is over hyping this treatment, and I’ve been around long enough to remember when they did this for CB-03-01 too. Some people were even saying it would be better than dutasteride. The most likely outcome is that pp405 works as a hair growth stimulant, and probably slows balding. It’s cool because it’s a novel mechanism and what makes this a good treatment is that it gives people alternatives. That being said, I doubt it will work long term as a monotherapy but will be great to add to a stack. For example, I tried 5AR inhibitors but I can’t tolerate them, so instead I run a stack of nizoral, pyrilutamide, minoxidil and alfatrodial and this has given me great maintenance. The more new drugs we have, the more choices we have to mix and match stacks to tailor it to what’s tolerable for us as individuals which is a very good thing. That’s good news, and the more tools we have, the more options we have to fight hairloss and we aren’t stuck with having to to either take finasteride/dutasteride or go bald. That being said, pp405 will probably be good as a stack with other drugs, hell it may even work great with minoxidil because you have two hair growth stimulants with different mechanisms of action, but we will still need to target androgens. If you can’t do that with a 5AR we now have pyrilutamide, CB-03-01, RU58841, and hopefully GT20029 in the future. None of these will cure baldness, and none of these will work for everybody and all of these need to be started before you’re bald but every few years we get more options to choose from making treatment more widely available for different peoples personal body chemistry. I don’t think pp405 is a flop, I think it will be a great addition in the future but I don’t think we’ll replace the need to inhibit androgens in the scalp ever because it’s an unavoidable issue.10
u/Brilliant_Run3426I agree was disappointed with today, but what they actually said was: "at a future medical meeting in 2026." Which does not specify today3
u/Specialist-Escape300because they only have 2a result1
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56r/ATHXHardy to present at the Congress of the Japanese Society for Regenerative Medici...imz7230%345.8regenerative medicine2026-03-04↗
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u/imz72[From the registries (machine-translated from Japanese)]: Multipotent adult progenitor cells for use in treating intracerebral hemorrhage - Patent Application 20070122999 Abstract [Problem] Multipotent adult progenitor cells for use in treating intracerebral hemorrhage are provided. [Solution] Aspects of the invention described herein relate to the administration of multipotent adult progenitor cells to treat intracerebral hemorrhage. Previously, stem cells have not been considered useful for treating ICH. As described herein, it has surprisingly been found that administering multipotent adult stem cells as described herein to treat ICH has an unexpected and surprisingly effective therapeutic benefit on ICH outcome, as shown by measures of hematoma volume, cerebral blood flow/perfusion outcome, and functional neurological assessment. ... Inventor: Robert Mays Current Assignee: Healios KK https://patents.google.com/patent/JP2025181956A/ja [Issuing Country] Japan Patent Office (JP) [Publication type] Patent publication [Registration date] 2026-02-20 [Issue Date] 2026-03-03 [Title of Invention] Multipotent adult progenitor cells for use in treating intracerebral hemorrhage International Patent Classification] ... [Number of claims] 52 Application date】2020-01-30 [Publication Date] 2022-04-25 [International Release Date] 2020-08-06 [Date of request for review] 2023-01-26 [Priority date] 2019-02-01 [Priority claiming country/region or organization] US [Name or Company Name] Healios Co., Ltd. ... [Claims] [Claim 1] A composition for treating intracerebral hemorrhage and reducing intracerebral hematoma volume in a subject, the composition comprising multipotent adult progenitor cells that express oct-4, rex-1, and rox-1, the multipotent adult progenitor cells being neither embryonic stem cells, nor embryonic germ cells, and capable of differentiating into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages, and being allogeneic or xenogeneic to the subject. ... https://ipforce.jp/patent-jp-P_B1-07822785 My [imz72] note: 1.I don't know what this procedure means. 2.In March 2021 Athersys published this abstract: Multipotent Adult Progenitor Cells as a Highly Promising Therapy for Treatment of Intracerebral Hemorrhage 3.In November 2021, Dr. Robert Mays, who was then Head of Neuroscience at Athersys, said in an interview: "We have ongoing preclinical work a number of indications, we've got the most of them continued down the line, including great hemorrhagic stroke data and we hope to be submitting that paper in 2022." However, this paper has not been published since. 4.In March 2022, BJ Lehmann, who was the Interim CEO of Athersys back then, said at a Maxim presentation: "Ischemic stroke, as I mentioned, is our lead indication. I think we all understand the nature of the opportunity to help patients here - significant and increasing incidence as the patient population ages. There's both ischemic stroke and hemorrhagic stroke. We've demonstrated in both varietals we can have potential effect. We've done clinical work in ischemic stroke, and just preclinical work in the hemorrhagic area, but we do believe we can impact both types of strokes in a meaningful way."3
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57r/physicianassistantCareer PivotShoppingObjective66630%345.8regenerative medicine2026-04-01↗
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u/bootyhole_licker69honestly 3 years out is still super early, you didn’t box yourself in at all. sell the procedures, comfort with needles, talking people through painful stuff, time management and running your own schedule. em and hosp both like folks who can be fast and independent. be ready to own the “i miss real medicine” narrative in interviews so it doesn’t sound like you’re just bored with aesthetics. and yeah, even as a PA it’s weirdly hard to move around now, hiring seems way messier than it should be3
u/foreverand2025I’ve always done traditional medicine but hope this is helpful: How did you market yourself coming from a non-traditional or niche field? Focus on the traditional medicine aspects you are doing. You are doing procedure. You are working with patients, writing notes, etc. ‱ What skills would you emphasize from a procedural/aesthetic background that translate well to EM or inpatient medicine? See above. ‱ Are there certain specialties that tend to be more open to PAs making a pivot like this early in their career? Medicine in general is so understaffed that most places are open to training you if you have a decent personality and are willing to learn. Apply broadly and to jobs that look like good gigs and interest you. ‱ Anything you wish you had done differently when making the switch? I’ve jumped around specialties my whole life. Just wrote another reply about this but we don’t really get pigeonholed. PAs are lifelong learners and by design meant to be flexible to fill gaps where needed. Find a doctor and/or group of seasoned PAs willing to train you, read from good sources on your own, etc. My general advice to people is pick a job based on pay, schedule, work culture, etc and weigh those things more heavily than specialty itself. I’ve been doing this over a decade now and believe that the specialty (unless you really hate or love it) falls quite a bit lower on the priority list than most people think. That said and with all due respect I’d 100% walk away from any kind of aesthetic/naturalist/etc type work. I’m not here to slam anyone and to each their own but especially as a newer PA I would strongly encourage you to stay in traditional medicine and look at aesthetic or whatever type work more of a field to go into once you’re truly seasoned and to do so just for pay/hours type reasons. Just my opinion.2
u/Ok_Glass_7213No advice but would love an update on this and how it goes!1
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58r/OverwatchMy idea for a Mercy reworkSquidIsALesbian0%1045.0regenerative medicine2026-03-24↗
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u/katyadcAs we are all aware, Mercy is just kinda boring to play as or against and has been for some time Counter point: we are not all aware that Mercy is kind of boring to play as or against and has been for some time. Because it isn't true. If you think Mercy is kind of boring to play maybe the better way to look at it is: "Mercy is boring for ME to play" and just don't play Mercy. No one is forcing anyone to play Mercy and from what I understand she gets banned a ton in comp (which I don't play), so what's the big deal? I find Mercy extremely fun to play because she forces you to pay attention to everything going on to be able to help the team and keep yourself alive. You're constantly making quick decisions out of the blue as situations change. There are all kinds of calculations a good Mercy needs to make in their head as to how much risk to put themselves in, etc. Honestly I kind of consider her a character for control freaks because she can give you much more precise control as to how to influence the game with making decisions as to who to heal/buff/rez or not. That's pretty stimulating, but ymmv if you are just playing her as a passive healer or buffer. A good mercy should be actively engaging with the events of the game. How is that boring? And, to be honest, if you think Mercy is kind of boring to play against... who cares? It's not up to other players to play characters or in a way that makes you happy or engaged. You gotta find that in yourself. Maybe I've missed them, but why do we never see as many posts about changing Widowmaker? We see them, but it's not NEARLY as many as on Mercy or some other characters. I mean isn't she boring to play as or against? She just sits in the back and plinks people. So exciting! C'mon.8
u/Creaddd_44Resurrect would essentially be unusable past Plat if it required line of sight throughout the full cast time. The average number of resurrections that high elo players get per 10 is around 3-4, and the majority of these are ones that are only able to be pulled off due to Mercy weaving behind cover.3
u/MaLLahoFFAs we are all aware ???????? I don't think Mercy is boring to play, play against, or has a bad design. "...give one of the most well known characters in the game a proper kit." She heals, damage boosts, has a sidearm, is top 3 best mobility in the game, and has a unique and game-warping ability. What part of that isn't a proper kit?3
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59r/stemcellsAre there cardiologists that specialize regenerative medicine?SoManyQuestions520010%944.7regenerative medicine2026-03-26↗
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u/Significant-Pear-545A great friend of mine is a Neurosurgeon and he happens to be a stem cell pioneer in South Florida. He's very easy to talk to and has a way of putting things in terms that are understandable for those of us who aren't literal brain surgeons lol. I know he offers some level of telemedicine but tbh I don't know the details. Let me know if you'd like his info and I'll be more than happy to connect you with each other. Best wishes on your journey!2
u/silverfolders3online physicians for this stuff sound dope, have you found any leads yet?2
u/slicesndicesI might use the email addresses you’ve already found (in your 2nd post) to 1) inquire of the services these providers offer and perhaps 2) elaborate on what you’re exactly looking for and 3) your cardiac history, if asked. And, ask if the cardiologist knows of any neurologists specializing in regenerative medicine. This type of medicine may be more advanced internationally in Mexico, India and Germany as of this date. I suspect OP might find some researchers helpful, if they are willing to communicate, their email addresses are generally found on their published studies.2
u/Thoreau80There are both at the Mayo Clinic.1
u/Bodigaron1981I have worked closely with a team of three cardiologists who did over 500 patients of stem cells for Ischemic Heart Disease. Two of them retired already, the last one I still see often for a study we are doing together. I have met a few of these guys but there are not so many with that kind of experience1
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60r/squarespaceHELP: Image Button Pop UpLow_Elevator_596520%344.1regenerative medicine2026-03-26↗
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u/Maximum_Truth_1832Squarespace doesn’t have native image hotspot hover like WordPress plugins, but you can recreate it with custom CSS positioning or embed tools like ThingLink. Just remember hover doesn’t work on mobile, so click popups are usually better. I’d probably map the interactions first in something like Runable before building it so positioning everything is easier.1
u/SeaJob544Squarespace doesn’t really have native hover popups like that, but you can get close a few ways. One option is using an image block with click-through + summary block below, then styling it to feel interactive. Another is using gallery sections with overlays, those let you show text on hover. If you need true pop-up style points, you’d probably need a little custom CSS/JS. I’ve seen people also fake it with accordion blocks tied to image sections. Are you trying to keep it mobile-friendly too? Hover effects can get tricky there.1
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61r/catsLooking For Advice And Personal Experience Administering Chlorumbucil & Prednisi...These-Yam-189210%743.8regenerative medicine2026-03-28↗
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u/bonniejeanne2The first thing I noticed wrong with my Mittens was that one pupil was larger than the other. They gave her steroid shots and antibiotics in case it was an infection. That didn't help, so got X-rays. A small spot appeared near her lungs, which they said might be cancer or she might have inhaled liquid. Then she quit eating and was throwing up white mucus. Ultrasound showed kidney infection. More injections and pills to make her want to eat, and still she wasn't better. Did another X-ray about 3 weeks after the first one and the spot near her lungs had grown considerably. Took her to LSU vet clinic which specializes in oncology 3 days ago. She had a fast growing cancer that had gotten into her bones and spread through her body that fast. They said they could do rounds of chemotherapy, that would require a lot of hospitalization, but might only give her 4-6 months more to live. Plus, it would cost several thousand dollars. I wasn't going to put her through all of that. She already hadn't been eating for a week or more. Picked her up Thursday morning and brought her home. She was so happy to be home. Gave her one more loving night here, then took her in yesterday to be put to sleep. Broke my heart. She was my little shadow. I had just lost my Poppy in February to intestinal cancer. I have two babies left and am praying they don't get sick. Spent over $3000 in vet bills in the last three months trying to save them. I hope your baby recovers.1
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62r/jovemedinamicaPortugal, a capital mundial de biohacking: apanhar sol e comer sardinhas. NĂŁo se...Green_Insurance4916140%1542.8regenerative medicine2026-03-13↗
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u/--____________-Porque Ă© que fazem isto. Escrevem assim. Isto faz imensa confusĂŁo. NĂŁo entendo. É estranho. A malta do linkedin Ă© assim. Escrevem. NĂŁo pensam. Porque Ă© que escrevem assim????13
u/sad-kittenxPqp, jĂĄ nĂŁo bastava tudo o resto.7
u/bartolomeudebragancaEsta gente vive mesmo numa bolha. Não devem conhecer a famosa pança de vinho verde tinto3
u/luckynarWalkable cities.... pessoal, nĂŁo se metam na droga.2
u/Lucky_Ad5440DĂĄ-me vĂłmitos essa conversa de IA Ex-pat... nĂŁo hĂĄ pachorra.2
u/and_guerrO The Algarve Ă© mesmo crime contra a humanidade fds1
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63r/ATHXSenior advisor at Boston Consulting Group questions Japan’s revised pricing rule...imz7220%242.8regenerative medicine2026-03-25↗
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u/imz72Machine-translated from Japanese: March 24, 2026 Astellas opens its Nakanoshima Cross lab to the public, showcasing automated cell culture using robots and AI On March 24, Astellas Pharma unveiled a development base opened by its joint venture with Yaskawa Electric, Cellafa Bioscience, at Nakanoshima Cross, a cutting-edge medical hub in Osaka. The base will combine the humanoid general-purpose robot "Maholo," developed by a subsidiary of Yaskawa Electric, with artificial intelligence (AI) to advance the practical application of automated cell culture technology. Cell therapy using iPS cells and other living cells means that variations in the manufacturing process directly impact quality. Traditionally, much of the process relied on the manual work of skilled technicians, making reproducibility and scaling up challenging. Maholo is said to automate more than 90% of the manufacturing process. Remote operation is also possible, contributing to labor savings on-site. At the event held on the same day, Cellafa President Hidehito Yamaguchi said, "We will introduce robots from the research stage and build a foundation that allows us to run everything from development to manufacturing in one place. We want to accelerate the industrialization of regenerative medicine." The company was established in September 2025 and will be engaged in contract work for universities and startups, developing cell manufacturing processes and manufacturing investigational drugs. The Nakanoshima Cross base will serve as a hub for incorporating cutting-edge technologies and coordinating with customers. https://www.nikkei.com/article/DGXZQOUF241070U6A320C2000000/1
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64r/bioinformaticsSeeking expert perspective: Is there a gap in cross-modality cell identity & dif...Which-Banana19470%542.7regenerative medicine2026-03-21↗
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u/standingdisorderYour questions are valid but cover things that are covered in recent review papers. You should look over those to find research gaps. To summarise those reviews in relation to your questions: efficiency can always be improved, not really (differentiation?), experimental iteration meaning what? Validation, sure. Scientists are not doing trial and error. You build evidence for targets and test if your evidence is supported. Literally every field. That’s science.4
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65r/10xPennyStocks$ADIA NEWS. Adia Nutrition, Inc. Reports Strong Revenue Growth in 2025 Annual Re...Loud-Relative-608430%42.3regenerative medicine2026-04-01↗
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66r/ReverseRhinoplastyRegenerative medicine in revision rhinoplastyhanginaroundthistown30%42.3regenerative medicine2026-03-05↗
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67r/StargateSG1Let's talk about Daniel Jackson (Long and spoilers, duh)Proxy_Janewbeginning40%1938.1regenerative medicine2026-03-16↗
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u/freehotsaucedragonYo, that was a wall of text that would make even Carter blush. I skimmed through it, I have some small thoughts. Daniel is annoying bleeding heart that can’t see past his own flawed perspective. However, I think there are times where the writers are against him because if he succeeded the SGC would get a over powered ally like Reese. This would severely undermined the threats the SGC faces. The sarcophagus example is similar to when O’Neill decided to not let the Eurondans survive the bombing because they were racist and attempted a genocide in the episode “The other side.” Yes the technology is advanced but allowing a war criminal to live is too high a moral burden to bare. I thought Jonas Quinn was a good replacement, but if you are looking for non team members the Tollan Narim would be a good choice. He would be a great moral compass but less bleeding heart. Great technical knowledge but not a great fighter or strategist.3
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u/Proxy_JanewbeginningA lot was accidentally deleted by a cat on the keyboard, here is what was able to be saved: https://www.dropbox.com/scl/fi/fyxip7qssp1jeib3ojvcs/Daniel.txt?rlkey=un9ilc1ch0j0rihnq9o327756&st=sbr7wsmj&dl=01
u/Proxy_JanewbeginningApparently nobody has anything to add lol1
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68r/Pennystock$ADIA News out yesterday was well received..closed up 29 percent.. News came out...Tommyboytrader12310%37.5regenerative medicine2026-04-02↗
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69r/wallstreet$ADIA News out yesterday was well received..closed up 29 percent.. News came out...Tommyboytrader12310%37.5regenerative medicine2026-04-02↗
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70r/ScienceNcoolThingsCalifornia Institute for Regenerative Medicine board approves a $100,000,000 rar...sillychillly10%137.5regenerative medicine2026-03-23↗
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u/sillychillly"As many as 1 in 10 people in the U.S. has a rare disease, many of which have no known cure. A new program by the California Institute for Regenerative Medicine (CIRM) could change this by funding novel ways to develop multiple genetic therapies for multiple rare diseases at the same time. The new rare disease funding program approved by the board will allocate $100 million over two years to support multiple platform technologies for rare diseases. These platforms each represent one approach that could ultimately result in treatments for many diseases. That’s good news for those patients and their families who might otherwise have no options. This new approach for developing therapies for rare diseases is known as the Rare Disease Acceleration Platform and Innovation and Delivery (RAPID). “RAPID is designed to fundamentally reshape how we advance treatments for people with rare diseases,” said Shyam Patel, PhD, CIRM Associate Vice President of Preclinical Development. “By focusing on scalable platform technologies, we’re accelerating individual projects while building an infrastructure that enables faster, more efficient development across entire categories of genetic conditions. These therapies not only have the potential to reduce lifetime healthcare costs but also will streamline the path of therapies to the clinic and ultimately ensure that promising therapies reach patients who otherwise have no options.”1
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71r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-25↗
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72r/moneymachinestocksWhat If Humans Could Regenerate Like Animals? Exploring the Science and Potentia...mm_newsletter10%137.5regenerative medicine2026-03-14↗
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u/mm_newsletterSource: https://www.usatoday.com/story/money/2025/06/28/stock-market-sp-500-forecast-2025-tariffs-recession/84353446007/1
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73r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-20↗
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74r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-18↗
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75r/ScienceJobsAssistant Professor of Rehabilitation and Regenerative Medicine at CUMCjobRxiv10%37.5regenerative medicine2026-03-18↗
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76r/uflRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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77r/collegecompareRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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78r/rutgersRutgers vs UF for Biotechnology (Regenerative Medicine / Stem Cells / Startup Go...FormerMarketing81920%37.5regenerative medicine2026-04-03↗
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79r/askCardiologyAre there cardiologists that specialize regenerative medicine?SoManyQuestions52000%37.5regenerative medicine2026-03-26↗
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80r/RimWorldI need MORE power. TELL ME HOW THIS INSTANT. (Please!)bonisbestboy0%1731.7regenerative medicine2026-03-17↗
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u/Tight_Good8140Don’t use smoke leaf it sucks4
u/Souls_for_sale_nowvoid3
u/freedomfire99Deathless gene, psycaster stuff, limb regeneration!2
u/Super-Contest7765And here is me, looking for mods that not only enhance the pawns, but allow us to give then like 2 hearts, 3 lungs, 3 kidneys and so on2
u/bonisbestboy[deleted]1
u/killchopdeluxe666What's that limb graphic from?1
u/laststand16can you share the mods you use?1
u/totallymarcBeyond our Reach Tenebral / Quasar level bionics. Haven’t yet gotten the tech needed for them but I was attacked by the Tenebral-level faction and I can safely say their bionics and gear are absolutely busted.1
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81r/QuantisnowCaribou Biosciences Announces the FDA Granted Regenerative Medicine Advanced The...Quantisnow10%22.5regenerative medicine2026-03-31↗
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82r/StockTitanCRBU | Caribou Biosciences Announces the FDA Granted Regenerative Medicine Advan...Stock_Titan10%22.5regenerative medicine2026-03-31↗