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1r/immortalistsAging is caused also by Telomere Shortening. By boosting Telomere Lengthening me...GarifalliaPapa4330%5476.9induced pluripotent stem cells2026-03-20↗
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u/GarifalliaPapaI am writing this for the other scientists who are interested in the aging science (advanced mechanisms): Telomeres are specialized DNA–protein complexes composed of repetitive TTAGGG sequences that cap chromosome ends, functioning as both replicative buffers and genomic stability guardians. Due to the end-replication problem inherent to DNA polymerase, a small portion of telomeric DNA is lost with each cell division, establishing a progressive shortening process that acts as a biological clock. However, telomeres are not merely passive counters; they also serve as sensors of cellular stress, integrating oxidative damage, inflammation, and metabolic dysfunction into signals that determine whether a cell continues dividing, enters senescence, or undergoes apoptosis. When telomeres reach a critically short length, they lose their protective T-loop structure, exposing chromosome ends and triggering a DNA damage response mediated by ATM and ATR kinases. This activates tumor suppressor pathways such as p53/p21 and p16INK4a/Rb, enforcing permanent cell-cycle arrest known as senescence. This phenomenon underlies the Hayflick limit, which defines the finite replicative capacity of somatic cells. In this state, cells remain metabolically active but lose proliferative ability, contributing to tissue aging and reduced regenerative capacity. Telomere shortening participates in a self-reinforcing feedback loop that amplifies aging processes. As telomeres shorten due to replication and oxidative stress, they activate DNA damage signaling, which induces senescence. Senescent cells then secrete a pro-inflammatory mixture of cytokines, growth factors, and proteases known as the senescence-associated secretory phenotype (SASP). This inflammatory output increases local and systemic oxidative stress, accelerating telomere attrition in neighboring cells. The result is a propagating wave of dysfunction that spreads across tissues, linking cellular-level damage to organism-level aging. This mechanism has clear implications for disease. In cardiovascular systems, telomere shortening in endothelial cells impairs vascular repair and promotes atherosclerosis. In cancer biology, short telomeres initially promote genomic instability through chromosome fusions and breakage–fusion–bridge cycles, increasing mutation rates; however, advanced tumors often reactivate telomerase to maintain unlimited proliferation. In neurodegeneration, reduced regenerative capacity combined with chronic inflammation contributes to neuronal loss. Metabolic diseases such as type 2 diabetes are also linked through inflammation-driven insulin resistance and cellular dysfunction. Strong causal evidence for telomere importance comes from genetic disorders such as dyskeratosis congenita, where mutations in telomerase components like TERT or TERC impair telomere maintenance. These conditions produce premature aging phenotypes, including bone marrow failure and organ degeneration, demonstrating that defective telomere biology alone is sufficient to drive systemic aging-like pathology. This reinforces the concept that telomeres are central regulators of long-term tissue integrity. Telomere attrition is significantly influenced by oxidative stress and inflammation, making lifestyle factors critical modulators. Combined aerobic and resistance exercise reduces systemic inflammation, enhances antioxidant defenses, and improves mitochondrial efficiency, thereby lowering reactive oxygen species (ROS) production. Chronic psychological stress, in contrast, dysregulates cortisol and activates inflammatory pathways such as NF-κB, accelerating telomere shortening. Practices like mindfulness and meditation have been shown to increase telomerase activity and reduce stress-induced damage, while adequate sleep supports DNA repair and limits inflammatory signaling. Nutritional inputs modulate telomere biology through redox balance and metabolic signaling pathways. Polyphenols such as those found in green tea, resveratrol, and quercetin activate protective pathways including SIRT1 and AMPK while inhibiting NF-κB, reducing oxidative damage to telomeric DNA. Curcumin exhibits strong anti-inflammatory effects and can stabilize telomeres in normal cells, though it may inhibit telomerase in cancer contexts. Micronutrients like vitamins C and E act as antioxidants, magnesium supports DNA repair enzymes, and vitamin D modulates immune responses. Omega-3 fatty acids further reduce inflammation and are associated with slower telomere shortening in longitudinal studies. Telomere length can be actively maintained by telomerase, an enzyme composed of TERT and TERC that extends telomeric DNA. While most somatic cells have low telomerase activity, certain interventions aim to enhance it. Compounds like TA-65 have shown modest telomere lengthening effects in humans, though variability exists across cell types. Hyperbaric oxygen therapy induces adaptive responses involving HIF-1α and antioxidneutral24
u/Mammoth_Mission_3524I take astragalosides, specifically Astragaloside IV and Cycloastragenol. I usually take 15-20mg a day of each. I also take NOVOS Core, which has Vitamin C, fisetin, magnesium malate. I take high doses vitamin D as well. I am 50 now, but will likely look like I am 6 next year, lol. 😂 There is a potential downside to lengthening telomeres. It may actually cause cancer. So, there’s that small itsy bitsy issue.neutral24
u/No-Falcon631Interesting, thyme has a positive effect on telomeres.positive12
u/ComplexTell25Can anyone TLDR are the stuff that lengthens telomeres? ?neutral5
u/Del_PhoenixI wonder if anyone has tried killing the telomeres? ?negative3
u/Adventurous-Soft-399I read an article recently about the worlds longest living woman maria branyas who had a huge erosion in her telomeres. She died aged 117. Scientist reckon that having short telomeres helped her live a long life and while long telomeres matter in younger people in old people the short cell life helps the body evade cancer cells.i think be cautious with trying to lenghten telomeres it might do more harm than good.neutral3
u/[deleted]Epithalonneutral2
u/Naven71Currently taking Epitalon. Wish there was some way to monitor and track the size of our telomeresneutral2
u/awesomes007I’ve had at least six years stolen from me by post viral damage. I’d love to have them back.neutral2
u/No-Poetry-2695Nice so much infoneutral2
u/MondoDismordoI was recently contacted by a company that produces a compound THEY say repairs telomere length. They wanted help with marketing their "compound". Fair enough, looks interesting. However, when I asked them about long term (like 10-20 year) clinical studies confirming their claims (so I could reference them in the marketing materials), they ghosted me. That was 6 months ago. Which is why I was attracted to this "article." Unfortunately, this reads like optimistic science journalism dressed up as authoritative medical writing, cherry-picking promising findings while glossing over uncertainties, risks, and the huge gap between mouse studies and proven human therapies. I won't even get into how much of this is AI generated. Just remember, AI's LOVE lto produce ong lists of things. And then the AI generated replies that go on for 10+ paragraphs. Good lord people, enough already. Remember, being cynical and skeptical is a good thing. Helps keep us all honest. (and yeah, we can easily tell when you are using AI to bolster your claims, it's not hard to see) Be well people, and don't believe everything you read on the Internet.neutral2
u/tollbooth_inspectorThe longevity field is a farse, and it is not coincidental we are seeing a push for it now. Elites are afraid of death. We have the tools now to really play with our biology, and it will not end well. People don't realize how incredibly complex biological systems truly are. They have been evolving and optimizing for millions of years (hominids alone). Every step we stray away from our optimized conditioning (hunter-gatherer, nomadic lifestyles) is a disruption to very complex cellular and genetic machinery. It's a hydra problem. In a fundamentally entropic reality, there is always a tradeoff to these sorts of things.negative2
u/Nook_n_Cranny1Regular exercise will likely prove to be the best supplement to prevent telomeres shortening.positive2
u/SenselessSilenceEpitalon (100-500 mcg subcutaneous), first ten days of every month. Over time, it keeps your telomeres elongated.neutral1
u/perkinsonlineDon't forget tunmo (Wim Hoffman breathing) too.neutral1
u/AwesomRenoIt’s a good hypothesis. I don’t think we are actually near the part of knowing distinctively the cause. Might even be a feedback loop we aren’t even aware of yet. Or could be as simple as cellular nucleus wall degradation. I remember learning a guy in Reno was trying for the longest time but all of the organisms always died from tumors or cancer metastasizing. Like, it be cool if it was actually the cause because it would make sense losing DNA over time ends the cell anyway but why does this mechanism exist?neutral1
u/Bobbyg2287Lobelia root...I think lolneutral1
u/Crypto_gambler952Longer telomeres mean more cancer though right? Cancer in old age is better than dying young though I suppose. ?negative1
u/GarifalliaPapaBest scientific research: [1] Telomere Length and Its Association with Aging-Related Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC11882723/ [2] Short Telomere Length and Increased Risk of Age-Related Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC3112149/ [3] Telomere Biology Disorders and Dyskeratosis Congenita Genetic Testing Panel https://dnatesting.uchicago.edu/tests/telomere-biology-disorderdyskeratosis-congenita-panel [4] Effects of Lifestyle Interventions on Telomere Length: Systematic Review and Meta-Analysis https://www.sciencedirect.com/science/article/abs/pii/S0047637422000768 [5] Obesity and Accelerated Leukocyte Telomere Shortening https://pmc.ncbi.nlm.nih.gov/articles/PMC9199514/ [6] Stress, Diet, and Metabolic Factors Associated with Telomere Length Changes https://pmc.ncbi.nlm.nih.gov/articles/PMC3384690/ [7] Vitamin D3 and Omega-3 Fatty Acid Supplementation Effects on Telomere Biology https://pubmed.ncbi.nlm.nih.gov/40409468/ [8] Polyphenols and Their Molecular Mechanisms in Regulating Telomere Biology https://pmc.ncbi.nlm.nih.gov/articles/PMC10049696/ [9] Telomeres, Telomerase, and the Effects of Curcumin on Aging https://pmc.ncbi.nlm.nih.gov/articles/PMC12650488/ [10] Telomerase Activator Supplement Increases Telomere Length in Humans (Randomized Controlled Trial) https://pubmed.ncbi.nlm.nih.gov/26950204/ [11] Hyperbaric Oxygen Therapy and Telomere Length Extension in Humans https://pmc.ncbi.nlm.nih.gov/articles/PMC7746357/ [12] Telomerase Gene Therapy Delays Aging and Extends Lifespan in Mice https://pmc.ncbi.nlm.nih.gov/articles/PMC3494070/ [13] NMN Supplementation and Its Effects on Telomere Length in Middle-Aged Adults https://www.nmn.com/news/nmn-improves-telomere-length-blood-cells-middle-aged-people [14] Yamanaka Factors and Partial Epigenetic Reprogramming in Cellular Aging https://drclarkstore.com/blogs/news/partial-epigenetic-reprogramming-using-yamanaka-factors-reversing-the-clock-on-cellular-aging [15] Biological Aging in Lobsters and the Concept of Negligible Senescence https://www.nhm.ac.uk/discover/are-lobsters-immortal.html [16] Senolytics Reduce DNA Damage and Telomere Dysfunction in Endothelial Cells https://agingcelljournal.org/Archive/Volume3/senolytics_reduce_endothelial_cell_dna_damage/ [17] Effects of Dasatinib, Quercetin, and Fisetin on Cellular Senescence and Telomere Function https://pmc.ncbi.nlm.nih.gov/articles/PMC10929829/ [18] Meditation-Induced Psychological Changes Linked to Improved Cellular Health https://www.ucdavis.edu/news/positive-psychological-changes-meditation-training-linked-cellular-health [19] Evidence on Meditation and Its Potential Effects on Aging and Telomeres https://www.cnn.com/2014/07/10/health/can-meditation-really-slow-aging [20] Longitudinal Study of Senolytics (Dasatinib, Quercetin, Fisetin) on Aging Biomarkers https://www.aging-us.com/news-room/A-Longitudinal-Study-on-Dasatinib-Quercetin-and-Fisetin-Senolytic-Interventionspositive
u/AdvancedWafer2470The Planet Earth is already over populated. Let the young ones rule.negative-8
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2r/ibsHow many diseases are masked by an IBS diagnosis?jmct162540%5374.5induced pluripotent stem cells2026-04-02↗
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u/255chekai always thought of it as a catch-all. dont know what it is? call it irritable bowel - a wildly vague label ?negative103
u/Anonymous_AnomaliI actually don’t believe IBS is real. It’s all something else that isn’t easy to diagnose, so doctors give up.negative94
u/b00bieb00mAmazing how many real pathologies have historically been labeled as IBS. Good thing the modern approach is still a fodmap diet, antacids and a gentle suggestion that it’s anxiety. Wouldn’t want all that progress to complicate thingsnegative58
u/facialtwitchTo me it’s a symptom not a syndrome, there’s always a cause and the medical community need to delve deeper than simple testingnegative47
u/Tiazza-Silver“Oh your tests came back normal! Guess you just have IBS” shrugneutral22
u/SteambunnyI lovingly call IBS “I be shitting” because thats all we know. I had biopsies that came out clean but LOOK like Crohns on the scans, was in the most common spot for it and the doc even told me we were going to investigate it. But sometimes I wonder if he got a good punch of the wrong part of “cobblestone” part of it. That is the area he biopsied was normal next to an abnormal part. I also am being investigated for non radiological axial spondylarthritis which is autoimmune. It seems to go hand in hand with IBD. So idk makes sense to me but the docs dont know yetnegative21
u/PokketMowseI had 'IBS' all my life. While I was living in the UK, turns out they actually bother testing you for celiac disease. Guess who can't digest gluten but never had any doctors try to figure that out for 30+ years!negative15
u/Wildcard982Rubber stamped as ibs for decades. Eventually figured out that even tiny quantities of butter in bread takes a full month to heal from.negative13
u/bbtom78As I've gone to more doctors, I've found that newly diagnosed Endo and ADHD are likely the causes of my IBS. With recent treatment, life has changed for the better. ADHD linked to higher risk of irritable bowel syndrome, global study reveals https://share.google/d3rDt5sbSD6ZUmhGOpositive13
u/lugasamomI need to copy this into a document with checkboxes as we eliminate (pun intended) what I do NOT have, apparently.negative10
u/jmct16Posted here for more details: https://www.reddit.com/r/IBSResearch/comments/1s9q90w/how_many_diseases_are_masked_by_an_ibs_diagnosis/neutral9
u/Miss_J1801Thank you for this super interesting and elaborate post. As someone who got 'diagnosed' with ibs by my GP without basically any research, I feel seen.positive9
u/Pure_Temporary_6349This is correct, and it's even named correctly for the scenario of not knowing the cause. I'm a pediatrician. In medicine the convention is to use "syndrome" for a collection of symptoms and signs that happen together more often than in the general population and more often than by chance but without a clear underlying cause. Many conditions now known to be due to a single gene mutation were initially labeled as various genetic syndromes before the genes were identified. Sometimes a collection of findings labeled a syndrome turns out to be from only one common cause and sometimes it turns out to be several different causes with similar end results. But I notice my colleagues seem to forget what "syndrome" means. It's still useful sometimes to try treatments that help a statistically significant number of people with a given syndrome even if the cause is unknown to researchers. Causes can take much longer to figure out than treatments-- just because a treatment can help does not mean the absence of it caused the problem. So it's a concept that can help patients if applied correctly.positive7
u/GraciousPeacockMy father had to spend 10+ years with “IBS” before becoming hospitalized to near death to finally be investigated and finding out he has Crohn’s Disease. I am 2 years with IBS now, and I am grateful I am managing it somewhat okay because it may take a while to get diagnosed if I do have Crohn’s. I feel for anyone who struggles with this unknown illness known as IBSnegative4
u/RedditHelloMahThis post is really helpful! I hope we see more informative posts like this instead of those “I cured my IBS… here’s how: 1) I told myself to stop, 2) I ate healthy, 3) you should too.”positive4
u/FixedFun1I have BAD but for most doctors it was IBS. So I agree.negative3
u/magicpennyOne that was missed and falls under congenital/ anatomic would be Tortuous Colon. I have that and was diagnosed as IBS-C. Symptoms are pretty much exactly the same, for me at least. So, I definitely have a tortuous colon and may or may not have IBS-C.negative3
u/adorkable-lesbianI hate the term IBS. It took me eight years to get diagnosed with something else because IBS stuck and everyone thought it was in my head. I’ve been on medication for lupus (SLE) for a year now and my symptoms are vastly better!negative3
u/Marshmallow920Can I ask why you censored the word cancer? ?negative2
u/idontknowwhythisughI see mine 🙋🏼‍♀️ SIBO was a bitchnegative2
u/A-TutFascinating! I have LAL-D and have suffered with IBS-D all my life. My disease is so rare, I've never seen it mentioned in an article before that wasn't specifically about LAL-D as the main topic. Although I've known my diarrhea is probably from my disease, it's nice to see the article support it.positive2
u/BulkySquirrel1492neutral2
u/cccmegancccMine turned out to be Small Fiber Neuropathy (SFN) with autonomic and sensory involvement. But I also suffer with chronic pain and fatigue, so my symptoms are not limited to the GI system.negative1
u/Last-Barracuda-6808Wow that is an extensive list. I wish I had a good specialist who would test me for some of those.positive1
u/MsFuschiaI'm not reading all that because it's clearly AI, can no one write for themselves anymore? ?negative-4
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3r/NooTopicsEverychem PP405 Patent Breakdown (3HPs, PP30 & 2HEE)sirsadalot1670%7473.7induced pluripotent stem cells2026-03-13↗
commentercommentsentimentupvotes
u/SpenseRogerInsane the amount of work that went into this. Will order to show support.positive20
u/caprisumsbasedneutral15
u/SonnyshutMay the hairline be with youneutral14
u/DeanoPrestonThere's speculation that this may reverse graying, too.positive6
u/Burntoutn3rdThis is an insane level of dedication coming out of a novel chemical vendor. Nothing but high praise here from someone on the academic research side.positive6
u/Big-Tooth1671Look it research chems, what more can we ask of a company. I have as much faith as i can in there stuff for what it is .they try be as transparent as possible admit when they get it wrong big thumbs up from me im no expert so take it as it as i see it and not gospel great prices great products a little bit work on customer services in getting back quicker then there onto a winner .Im sure not easy getting reliable staff for these sort of things. for them to be spot on im sure our pockets get hit harder and we not all in a place to deal with it . I got banned from nootropcs for life no reason after asking why im sure its because i champion and tell people that i go everychem . Love acd856 favourite product sure it gave me mind set to get off long term opiods .positive5
u/Unlikely-Blacksmith1Is there any signs of regrowth anywhere by using your product yetneutral3
u/Spare_Entry_2441I want to get 1 which one should i get? and would it work for beards as well? ?neutral3
u/ThemeAppropriate575Guys I have disorders and I can read what is posted here, can someone sum up what is written above? ?neutral3
u/Great_Cow6624Where can i buy pp405? ?negative3
u/makefriends420Hope we can figure out what is what, doesn't seem like figuring out the structure is as possible as it was with ACD.negative2
u/Kobiash1Impressive work. Agreed with the red herrings though. Companies often file patents for hundreds of molecules to hide the real one. 2HEE or 3HP might just be analogs. However, synthesizing cyanoacrylates and pyrrolopyridines requires incredible precision. Impurities in grey market batches could cause scalp issues which would mimic hair loss rather than fix it. That would be a big red flag for me at this point because it's a best-guess, which carries the risk inherant with experimental chemicals and unknown toxicity, plus stability issues.neutral2
u/BrainWashedChimeraThis is extremely impressive..positive2
u/Sufficient-Mall-4210Is this true? PP30 matches the public patent chemistry trail more closely than 3HP. The main reasons are: • The public Pelage/UCLA chemistry points to a cyanoacrylate MPC-inhibitor scaffold with an azaindole/pyrrolopyridine-type core, not to a simple “3HP” concept. • PP30’s structure fits that published family better: it has the same broad azaindole/pyrrolopyridine + cyanoacrylate architecture and uses a 3,5-bis(trifluoromethyl)benzyl motif, which is closer to the public lead series. • The patent language explicitly allows prodrugs and specifically mentions acyloxy substituents such as acetyloxy, which makes PP30’s acetyloxyethyl ester look like a more natural patent-inspired delivery form. • I could not find 3-hydroxypropyl / 3HP specifically called out in the patent or the public medicinal-chemistry paper, so 3HP looks more like a looser guess built from the same general family rather than the strongest fit. • Even EveryChem says it does not know what the real PP405 uses and that its products are only examples based on public patents, so neither is confirmed — but PP30 is the closer match on paper. So the shortest version is: PP30 looks more likely than 3HP because it lines up better with the published MPC-inhibitor scaffold and with the patent’s prodrug/acyloxy clues. 3HP still looks related, but less specifically supported. ?neutral2
u/Unusual_Jackfruit146Looking forward to hearing good newspositive2
u/SoupBandIs anyone trying it now? Please reply to this comment so I can better follow your changes LMAO ?neutral1
u/PuzzleheadedPeace360Hi OP, Im new to all of this but wd like to try. I see two products; PP30 and 3HP. Which one should I pick and what is the dosage. thanks!neutral1
u/West_Marionberry_819If you were to buy all three hair-regrowth treatments, would you apply them all back-to-back on the scalp as we don't know which one is the real PP405? Or would you trial each one individually (say 4-8 weeks) and see what sort of results are achieved this way? ?neutral1
u/Sharp-Huckleberry862You used ODEs wow very impressivepositive1
u/Sufficient-Mall-4210how did you guys order from Everychem? my debit cards don't seem to be accepted and I tried a few ?negative1
u/steve228ukWhat dose are people taking? ?negative1
u/Sea-Adhesiveness-928Any issue with ordering from everychem at the moment? Keep getting some error code that it doesn’t let me give my card details to make a payment? ?negative1
u/tribemember321Is there a tldr for negative side effects? Or is the worst thing that can happen is it doesn’t work (3HP) ?negative1
u/Tasty_Bite_1973I've ordered 8 bottles of 3HP. I'd love to know the exact dosage that people are currently using daily. Anyone here have that info? ?neutral1
u/Abel_091this is really cool and impressive but is it like a replacement for antiandrogen? meaning I get its a different mechanism but it seems best ways to treat hairloss (of what available) a) growth stimulant b) antiandrogen does this compound suggest no longer needing either if it works? 100% down to order I use a topical Finasteride. Does this need to be mixed or comes fully ready? ?neutral1
u/[deleted][removed]neutral
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4r/Livimmune2026 AACR Glioblastoma Multiforme Poster & AbstractMGK_2930%4969.9induced pluripotent stem cells2026-03-23↗
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u/Tra-Kal34Would love to know what the conversations are with Big Pharma at the moment? ?negative33
u/Chemical_Sky6013Thank you u/MGK_2 once again for an excellent post. I've written in the past about my long journey with CYDY, and many of you have shared similar experiences. It's been really hard to stay invested for all these years and not lose hope. What I didn't share earlier, was that around the time that this thing hit 14 cents in November 2024, I saw a post on FB that said, "Sometimes when you're in a dark place, you think you've been buried, but you've actually been planted." And that's when I told myself it was time to start buying again. And now those seeds are about to bloom for all of us! This company is almost entirely owned by individuals... who kept the faith when everyone "in the know" fled. And soon we will have a beautiful garden to enjoy. Congratulations to all the longs!positive33
u/CytosphereThis is an excellent explanation of complex phenomena.positive28
u/Tra-Kal34Praise the Lord, we are getting closer and closer.positive27
u/paistecymbalsrockThe data has arrived!positive24
u/upCYDYWahoooooo ‼️ thank you MGK for this thorough explanation‼️🧨🙌🙌🙌 THIS🤗👍‼️FANTASTIC NEWS 💃positive23
u/surfgolf4lifeGreat post MGK. Patiently waiting for PRs and more good news👏👏👏positive23
u/Jtzdad5673A couple of years ago my niece told me about a friend, a close friend; who was intelligent and kind. He had everything it took to lead a very successful life, until he was diagnosed with GBM. He faced his illness with great courage and grit. He truly lived “one day at a time” knowing he didn’t have much time left. When my niece told me about his illness, I immediately told her about CytoDyn and leronlimab. I continued to stress the importance of having his physicians use the “Right To Try” statute and get him on leronlimab. Of course his physicians never heard of CytoDyn or leronlimab, nothing came of it, and once again the GBM won. I think he lived about 18 months after his diagnosis. He wasn’t even 30 years old when he died. The same thing happened when my cousin with a wife and four children had a massive stroke a few years ago. (I’ve posted about this here before). I called CytoDyn myself to request leronlimab for my cousin and Dr Scott Kelly was more than willing to send it to his physicians in Houston, but they (his doctors) refused to contact CytoDyn. He died six months later, on his 50th birthday. Had their doctors followed through, both the young man and my cousin might be alive today. Go CYDY!negative22
u/Pharma_JunkeeExcellent breakdown MGKpositive21
u/Missy2021Just a matter of time now, that Leronlimab blows the doors off of Big Pharma! Thanks again.positive20
u/Pharma_Junkee🙏🙏🙏positive19
u/UpwithstockBOOOOOM! Thank you for the plain language breakdown my brother! Your post was by far the best read I have had regarding the science! Loved: The abstract is a declaration of Kinetic Validation! The physics of the TME has been solved!! Now let the interested BP’s come to PAPA Dr. J and Uncle Hoffman! The Golden Tsunami is coming!!positive18
u/Pristine_Hunter_9506Thanks brother another step forward.positive17
u/megadunamisThank you for your analysis of the results. GBM is a tough cancer to crack, call Leronlimab to the rescue...positive15
u/twinter11That was nice write up! And it look like pestell and team were hard at it and I'm sure more to learn. I can't think of anything to ask Thanks Mgk!positive15
u/Doctor-MTJMGK, This IMHO is one of your very best posts. Great explanations of very complex processes in a very concise, easy to understand manor...Thank you my friend for all that you do! Things are really coelescing at a very fast rate right now. It feels like this is all leading to a big Crescendo very soon!positive15
u/waxonwaxoff2920Many thanks for the work you do here MGK. YOU ARE APPRECIATED BROTHER. 🫡15
u/No_Mathematician299I don't have anything to add to the discussion other than thank you. Thank you, MGK_2, for helping us make sense of everything. Thank you, Cytodyn's team. They are a bunch of diamond cutters, working tirelessly. I even thank myself for holding on during the bad times.positive13
u/Lopsided_Roof_6640Thanks MGK for the breakdown. Let us see what the new FDA does with this data. CRC, TNBC, and now GBM would meet any definition of unmet needs. Hard to ignore a hat trick. Notice that Pancreatic cancer has popped up here and there in Cytodyn literature. Would not be surprised if it gets a mention in the next update.11
u/AggieEC3After reading through the original post and many of the responses there’s a lot to unpack here, but stepping back, what stands out most is how the conversation is evolving from what could happen to how this might actually work in practice. The breakdown around glioma stem cells and OCR is especially compelling. If recurrence is truly being driven by those “seeds,” and this approach is impacting the metabolic engine that keeps them alive, that’s not just incremental, that’s getting closer to the root of the problem. The idea of starving out the cells responsible for regrowth, rather than just cutting down the visible tumor, is a meaningful shift in how this disease is approached. Where it really starts to connect is on the combination side. GBM has been the place where a lot of otherwise successful therapies go to stall out. If the issue has been access, both physical and immunological, and that barrier can be altered, then it makes sense why pairing becomes the focus rather than replacement. “Prime and pair” isn’t just a strategy, it’s a different lens. The OCR data, the dose dependency, and the early signals around reduced spread all point in the same direction, but like anything in this space, it still has to translate clinically. That’s the next step that matters. If it does, then the implications go well beyond a single indication. Appreciate the way this was laid out, it helps connect a lot of dots that don’t usually get tied together in one place. And to build on the analogy… if checkpoint inhibitors are a high performance engine, and this approach is about finally giving them traction, then maybe another way to look at it is this… right now, the system looks like a luxury car with a manual transmission, but no clutch. All the power is there, all the engineering is there but without that missing piece, nothing engages the way it’s supposed to. If this data holds, we may finally be looking at what allows the gears to actually connect. Thank you MGK_2 for continuing to bring clarity, put in the time, and connect the data in a way that moves the conversation forward.11
u/CytomightThis is turning out to be a BIG DEAL‼️😁😆positive10
u/Practical-Archer-124[deleted]neutral8
u/jsinvest09As I was reading that I could literally hear the excitement in your voice MGK.. are time is here. Are time is now?So, enjoy everyone, because here it comes...7
u/jsinvest09Good morning6
u/sunraydocThanks, MGK, you are the rock. That OCR reduction in the hypoxic tumor center really stood out for me, Yet another previously undiscovered MOA.2
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5r/HotScienceNewsWorld's first stem cell treatment for heart failure approvedsoulpost2670%868.5induced pluripotent stem cells2026-03-14↗
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u/Big_Car_7725This sounds really cool!positive5
u/Jaxson-rosThis is a huge milestone for regenerative medicine. Seeing stem cell based treatments like this move from research to real patient use is incredible and gives a lot of hope for people with severe heart conditions. It shows how quickly the field is evolving. For anyone curious about how stem cells are already being explored in different therapies today, resources from places like The Stem Cell Club are worth checking out to learn more about current developments.positive3
u/fhwoompableCooperWe would have been farther along if we were allowed to used the stem cells that got banned, don't understand the ethical concern once the fucker is outnegative3
u/Lifeabroad86Awesome possumpositive1
u/hanginaroundthistownHoping this will trigger other companies or research groups, as well as funding, now that regenerative medicine is 'now', and thus realistically attainable. (Although things like MACI are also forms of regenerative medicine and have existed for a while). Also, this article includes a new drug for Parkinson's!positive1
u/lingonberry_gspWish they would try it out on Michael J Fox!negative1
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6r/scienceRETRACTED: Prevention of acute myocardial infarction induced heart failure by in...shiruken1850%766.5induced pluripotent stem cells2026-04-01↗
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u/SaltZookeepergame691I’d love to be surprised but… well. I’ll add that the retraction note doesn’t even cover some of the most serious initial issues, doesn’t address that the BMJ seemingly didn’t bother to check registration details on the trial register, and also during peer-review failed to send the paper back to the most critical reviewer. Baffling all round from a supposedly rigorous journal.neutral67
u/Dr_Doctor_DocGet 'em! Science & Rigor > Ambition and Famepositive13
u/toughtacosFreakonomics Radio has a series about academic fraud that I really recommend listening to. It goes into depth about exactly this kind of thing. Very interesting listen.positive1
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7r/covidlonghaulersPluripotent stem-cell-based screening uncovers sildenafil (Viagra) as a mitochon...SpaceXCoyote660%2666.3induced pluripotent stem cells2026-03-18↗
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u/worksHardnotSmartOk, so I gotta walk around with a constant boner to get my life back? I'm game. ?positive21
u/Caster_of_spellsWow, that’s some unexpected hopium haha. Who’s gonna volunteer? ?negative16
u/GentlemenHODLCialis is well known in both the lifting and longevity community for being a overall health generator. It makes sense that Viagra would have some similar positive data as well. Both do the same thing - vasodilation. Look into the long-term outcome of taking 2.5-5mg of Cialis daily... You will be blown away by all of the positive health outcomes. I keep it at 2.5 otherwise my boners wake me up at night. It's a all around positive.positive15
u/in2go_outMakes sense. Long Covid/ME/CFS is a micro vascular disease, increasing the potency of nitric oxide would help those capillaries dilate.neutral12
u/reticonumxvI used sildenafil for brain hypoperfusion, it gave me a "pump" feeling in the head similar to Alpha-GPC; I guess it worked over time with all the other stuff. I still have two packs unused.positive5
u/jsgoetzDo you think cialis would have similar benefits? Longer half life would be more ideal i would imagine. I'm already worried about how drastically my vascularity has declined over the past five years. I've been pushing my doc for low dose cialis for this reason alone. ?negative3
u/SpaceXCoyote[deleted]neutral2
u/Silent-Razzmatazz957This may be the stupidest question ever, but do women take this too? Is it basically like just increasing blood flow and thus I guess activity in cells? Is it safe? Could it promote too much growth/cancer? Lots of research to do I guess. Gotta be honest, viagra of all things wasn’t on my radar lolll ?negative1
u/Don_FordIt's been helping with LC this whole time. We've long thought it's why older men have a lower prevalence of LC, because it would hide quite a few symptoms.positive-2
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8r/HFYChild of the Stars 4 (Revised)Maxton1811790%1264.6induced pluripotent stem cells2026-03-21↗
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u/Great-Chaos-DeltaSo far nothing out of the oryginal one but hey it still super coolpositive7
u/HFYWaffle/u/Maxton1811 (wiki) has posted 131 other stories, including: Child of the Stars 3 (Revised) Child of the Stars 2 (Revised) Child of the Stars 1 (Revised) The Impossible Planet 11 The Impossible Planet 10 The Impossible Planet 9 The Impossible Planet 8 Denied Sapience 24 The Impossible Planet 7 The Impossible Planet 6 The Impossible Planet 5 The Impossible Planet 4 The Impossible Planet 3 The Impossible Planet 2 Child of the Stars 19 The Impossible Planet Denied Sapience 23 Child of the Stars 18 Denied Sapience 22 Child of the Stars 17 This comment was automatically generated by Waffle v.4.7.8 'Biscotti'. Message the mods if you have any issues with Waffle.neutral3
u/ProfessorWorking3763"...the lab door once again slid open to reveal a suited one now staring directly at me." Samael: Ooh DoorDash!neutral3
u/KanadianKitsuneit demonstrates remarkable resistance or even outright immunity to [...] the synthetic VX nerve toxin. Breaking News! Organism without nerves or muscles survives chemical agent that disrupts the function of motor neurons!positive2
u/UpdateMeBotClick here to subscribe to u/Maxton1811 and receive a message every time they post. Info Request Update Your Updates Feedbackneutral2
u/kristinpeanutsThanks for the chapter!positive2
u/animeshshukla30Great chapter! And i agree, no matter how evil the scientist, no one is stupid enough to be thrilled about the military turning the alien organism into a weapon.positive2
u/ChiliAndRamenIntrigueneutral1
u/un_pogazWhen you catch the child with their tendrils in the cookie jar.negative1
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9r/IBSResearchHow many diseases are masked by an IBS diagnosis?jmct16590%1864.6induced pluripotent stem cells2026-04-01↗
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u/jmct16Finally published. Made with Deepseek, Claude, and OpenEvidence. I think it's the most exhaustive list you can find on IBS mimics. Christensen (1994) and Camilleri and Boeckxstaens (2023) served as starting papers, and then I added a few more entities that I remembered. u/Robert_Larsson, if any diagnosis is missing, please let me know. I've been wanting to make this post for quite some time.neutral11
u/ariaxwestThis is awesome! I've also thought about this a lot as I've had at least two diagnoses missed and been diagnosed with IBS. I wasn't diagnosed with celiac disease until I was 30 years old, despite being in constant pain and suffering from reduced nutrient absorption since I was a baby. Under inflammatory and immunologic entities, you should include food allergies and hypersensitivity to metals and chemical compounds. My daughter had been diagnosed with IBS-C, but in reality she had casein allergy. Dairy free diet ended her constipation. I don't think we ever would have figured this out if she hadn't had allergy testing. Starting a few years after going gluten-free due to celiac disease, I again had severe diarrhea over a long period of time. This time I became so ill that I almost died, and again of course was diagnosed with IBS-D. This time it was due to nickel hypersensitivity. I was finally diagnosed by a dermatologist. Nickel hypersensitivity in particular causes so much intestinal inflammation and symptoms identical to IBS. One study I read found previously unknown and undiagnosed nickel hypersensitivity in almost 40% of patients who had been diagnosed with IBS.neutral10
u/jmct16Missed some (by Grok) Trehalase deficiency: Malabsorption of trehalose (found in mushrooms and certain insects), causing fermentation and IBS-like symptoms after specific ingestion. Biomarker: Trehalose hydrogen breath test or genotyping. Status: Rare but under-recognized; in active separation in centers performing expanded disaccharidase testing. Dyssynergic Defecation (also called pelvic floor dyssynergia or anismus): Impaired coordination between abdominal push and pelvic floor relaxation during defecation, leading to straining, incomplete evacuation, and symptoms indistinguishable from severe IBS-C. Biomarkers: High-resolution anorectal manometry + balloon expulsion test (BET); defecography. Status: Fully separated in guidelines for refractory constipation. Rome IV now allows diagnosis alongside IBS-C. Biofeedback therapy is highly effective (success rates >70%), often curative, and is recommended before labeling patients as having refractory functional constipation or IBS-C. This entity exemplifies how "IBS" can be an artifact of incomplete physiological testing. Persistent post-viral or post-COVID gastrointestinal symptoms: Low-grade inflammation, dysmotility, or barrier dysfunction following acute viral gastroenteritis (including SARS-CoV-2). Shares biology with classic post-infectious IBS (PI-IBS) but has surged post-pandemic. Status: Nosological debate ongoing (similar to PI-IBS); some propose "reactive gut disorder" or "long gut" as distinct labels. History of infection plus exclusion of other causes is key. Symptomatic uncomplicated diverticular disease (SDD): Chronic abdominal pain, bloating, and altered bowel habits in the presence of diverticula without overt inflammation. Status: Largely consolidated separation (already noted by Christensen in 1994), yet still frequently mislabeled as IBS in older patients. Cantu syndrome-related GI dysmotility (mutations in KCNJ8/ABCC9 — KATP channels): Gain of function leads to intestinal contractility dysfunction. Status: rare, but an elegant example of channelopathy beyond SCN5A/GUCY2C; reported in humans and murine models with severe cold. Dyssynergic defecation (ou pelvic floor dysfunction / anismus): Contradição na coordenação do assoalho pélvico durante evacuação, mimetizando IBS-C grave. Biomarcadores: manometria anorretal + teste de balão de expulsão. Status: fully separated em guidelines (ACG recomenda testes fisiológicos em refratários); biofeedback é tratamento curativo em muitos casos. Prevalência alta em IBS-C refratária. Eosinophilic activation in IBS-D (without frank eosinophilic gastroenteritis): Increased activated eosinophils in the jejunal/colon mucosa, correlated with severity in IBS-D. They produce CRF and contribute to hypersensitivity. Biomarker: eosinophil count/immunohistochemistry in biopsy + activation markers. Status: in advanced research; not fully isolated, but explains subgroup with low-grade inflammation. Dyssynergic defecation (or pelvic floor dysfunction/anismus): Contradiction in the coordination of the pelvic floor during defecation, mimicking severe IBS-C. Biomarkers: anorectal manometry + expulsion balloon test. Status: fully separated in guidelines (ACG recommends physiological testing in refractory cases); biofeedback is curative treatment in many cases. High prevalence in refractory IBS-C. Giardia lamblia (giardiasis) a classic — yet frequently under-appreciated — example of a condition that migrates out of the broad IBS diagnosis, particularly in the context of post-infectious IBS (PI-IBS) and chronic diarrhea workups. Dientamoeba fragilis: Causes chronic diarrhea, abdominal pain, and IBS-like symptoms; known for propensity to cause prolonged infections. Frequently overlooked because standard labs may not perform the required stained smears. Biomarker/Diagnosis: Microscopy of stained fecal smears or PCR. Status: Emerging recognition as a treatable cause of chronic symptoms misdiagnosed as IBS. Cryptosporidium spp.: Waterborne parasite causing prolonged diarrhea, especially in outbreaks or immunocompromised patients. Strongly associated with PI-IBS development, with symptoms persisting long after clearance. Biomarker/Diagnosis: Stool antigen or PCR. Status: Well-documented trigger for PI-IBS; separable with specific testing in chronic diarrhea workups. Cyclospora cayetanensis: Similar to Cryptosporidium; causes watery diarrhea and fatigue, often linked to contaminated produce. Can lead to prolonged or post-infectious symptoms. Biomarker/Diagnosis: Stool microscopy or PCR. Entamoeba histolytica (non-dysenteric amebic colitis): In endemic areas or travelers, it mimics IBS-D with chronic diarrhea and pain without overt dysentery. Non-invasive forms are particularly hard to distinguish from functional disorders. Biomarker/Diagnosis: Stool antigen/PCR (distinguish from non-pathogenic E. dispar). Status: Classic mimicker; guidelines recommend testing in appropriate risk groups.negative9
u/VisiblePlatform6704Another one that may need to be included:  A1 Casein intolerance: A1 casein intolerance is a condition where digestion of the A1 beta-casein protein found in most European dairy cattle releases beta-casomorphin-7 (BCM-7), a peptide that activates opioid receptors in the gastrointestinal tract and causes symptoms mimicking lactose intolerance. Unlike true lactose intolerance, which stems from insufficient lactase enzyme activity, A1 intolerance is linked to the A1 beta-casein variant produced by a mutation that occurred in European cattle roughly 5,000–10,000 years ago, whereas A2 beta-casein (found in Asian/African cattle and some modern breeds) does not release significant amounts of BCM-7 I've got a VERY strong case of this, so much that even eating something like chips that have "milk powder" would provoke swollen intestines,  diarrhea and other stuff.  Meanwhile,  drinking/eating A2 casein milks is completely fine.neutral6
u/GastronomicusAll of them. That's what IBS is - a collection of GI issues without a diagnosis of disease. Every one of them has a disease behind it, but they're sometimes difficult to detect.negative5
u/ariaxwestAnother possible missed diagnosis: congenital anatomical differences. Possibilities include intestinal hypermobility, common in people with HEDS, Hirschsprung’s disease, and intestinal malrotation.neutral4
u/Ambitious-Ad-4301I have to say, I often wonder how easy it would be to miss that you may have colon cancer due to some of the effects of IBS and what is normal for you is also what is sometimes the first signs of cancer.negative4
u/Robert_LarssonWhat I can come up with from memory only: SLC5A1 Gene causing Glucose-Galactose malabsorption (carb enzyme category) DGAT1 mutation causing diarrhea Stem cell proliferation (covered by the original causes above in part) Cystic Fibrosis (doesn't mask IBS but GI issues and EPI are common and forgotten) Adrenal Insufficiency (GI issues often forgotten and labelled functional) We could probably expand this list by going more into detail on some categories like the neuropathies or immune activation, not to speak of the intestinal microenvironment where dysbiosis, parasites and infections can be of so many origins. The problem is that we are diving in from meta to minutia so quickly and frequently, it becomes hard to keep track. Nice work buddy, we should be doing more of this to keep it moving in future.neutral3
u/magskiiExcellent. Another one not on the list, from the UK: My mum was initially diagnosed with IBS when what she actually had was a huge gallstone. No one bothered to offer any tests other than basic bloodwork. They only figured it out when she had an ultrasound for a completely different reason. The technician spotted and mentioned it, assuming my mum already knew because it was so obvious!negative2
u/jmct16u/BulkySquirrel1492 Finally, a detailed review. It considers mimickers to be rare. There are many entities to be considered beyond a 'positive IBS diagnosis'.positive1
u/frankwittgensteinIt's a useful summary which goes on to show the political and economic dimensions of diagnosing people with "severe DGBI". I'd say it's a more difficult task to organize this topic into fully distinct entities than in this table, as there is some inevitable overlap, e.g. some of the congenital diseases here will also be neuropathies (Hirschprung's), some of the metabolic/neurological may also be congenital/hereditary (mitochondrial diseases), and so on. Another thing is that in some cases etiologies are listed alongside diseases/phenotypes, e.g. myenteric plexitis is likely etiology of some cases of enteric neuropathies, like CIPO. Apart from that, the immune system may also be a driver of mitochondrial diseases (Hanaford and Johnson 2022, for instance). Which brings us to another point, that there will also be some overlap in etiologies within a single disease, i.e. GI symptoms in some autoimmune diseases will likely be a mixture of mitochondriopathies, connective tissue autoimmunity and neuropathy. Within diseases with neuropathy, etiologies can span both large- and small-fibers, or be limited to small-fiber neuropathy of ENS and/or PNS. You could also add autoimmune/rheumatic diseases into the table (in fact, I have an entire book on gastrointestinal manifestations of rheumatic diseases) — Sjogren's, RA, Enteropathic Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, SLE, Scleroderma, Myositis, Vasculitis. Again, they will often have a mixed etiology, e.g. in Sjogren's, GI symptoms being the outcome of a mix of xerostomia, small-fiber neuropathy and probably connective tissue autoimmunity, which will also inevitably vary between patients. On a more microscopic scale, mitochondria will likely be affected too. IBS diagnosis probably won't mask them, but some clinicians like to refer to GI symptoms of people already diagnosed with those rheumtic diseases as IBS, FD and so on, which is obviously incorrect (this opens another discussion on where to draw the line between "comorbidity" and the actual symptom in a subset of patients diagnosed with the disease). There is also more recently described Yao Syndrome, which actually has similar genetic mutations to Crohn's (NOD2 gene). On a side note, I'd be cautious with overly relying on commercial LLMs used for similar tasks, as they are subject to capitalist logic as everything else (the same logic, that within the medical framework gave us DGBI in order to save healthcare spending per capita) — their main purpose is to appeal to investors. They are often correct (I find them useful on occasion too, mostly for preliminary looking for a query that will be too specific for standard search engines), but they will bridge the gaps in data with making conjectures, as what attracts investors is a technology that sounds smart and confident, even when data on the topic is pretty limited. They may also share biases of the research they are aggregating.neutral1
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10r/antinatalismBrain Farming is no longer sci-fiPomegranateLost1085430%1362.2induced pluripotent stem cells2026-03-19↗
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u/SunOverGravesIt is unethical experimentation. I am excited by science and scientific discovery, however I do believe people should push more health research and new sustainable energy. This bullshit is some "I have no mouth and I must scream" type of experimentation.negative9
u/akhattenEven worse, they managed to replicare the entire brain of a fly and put it into a simulated environment and body. We are speedrunning to altered carbonpositive8
u/CapedCapererThank you for the great post. I think bio-data centers sound like a scam for securing funding from venture capitalists. It's definitely unethical. I see they are trying to wrap this scam in greenwashing which is another tell that the promised technology will be undeliverable. So far they have only managed to create chips that lose at playing DOOM. Just in case, not reproducing and cremation are my defense systems.negative5
u/RiverOddDo you want AM? Because this is how you get AM. ?positive2
u/Eldarkshine08Cruelty squad ☠️negative2
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u/Low-Scallion8793This is SO unethical tbhnegative1
u/Aquarius52216Well morals were always in the furthest back or not even in the equation for these ghouls after all. Who the hell cares if we are inventing a literal comically cruel agony matrix if it help nett us 2% growth on the next quarter revenue right?negative1
u/ZwsgvbhmkOkay so I ain't no scientist but I believe it takes more than a few cells on a chip to have a fully concious mind. Our brains are huge and we use a pretty large part of it for everything that makes us "us". There's way more animals that don't have a concept of "self" than there are who do. I think it's very unlikely that we could create something that's concious on such a small scale and it's even less likely that it would be self aware and it's pretty much impossible that it could ever have concepts like "Oh got I'm trapped in have no body i have no mouth". So yeah this probably won't turn into man made horrors beyond human comprehension.neutral1
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11r/ICSELata and her f*cking potatosNo-Couple2071390%1562.2induced pluripotent stem cells2026-03-12↗
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u/Majestic-Variety3348NOT RAGEBAITING, but can you tell me what was so hard about that potato question? I personally found the question paper quite difficult and messed up some questions myself, but the potato question was pretty simple and straightforward and probably one of the easiest questions in the entire paper. I genuinely wanna know why everyone finds that question difficult ?neutral15
u/Substantial-Bid-9934Exam khatam nahi hue kya?? ( 99 in bio btw ) ?neutral1
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12r/HFYThe Gardens of Deathworlders (Part 165)micktalian470%660.1induced pluripotent stem cells2026-03-11↗
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u/Thaum0sI really need some of that good crab goo, just put me in the goo boss.positive4
u/kristinpeanutsThanks for the chapter!positive2
u/AutoModeratorThis was flaired as [OC-Series], it is a single part or chapter in a larger series or universe. The first post or part in this series should be (re)flaired as [OC-FirstOfSeries]. A description of the flairs and how to change yours is available in the Post Guildelines. [OC-Series] For original, self post, story, audio, or artwork that you have created, as part of a longer-running series or universe. Our preferred series title format is the series title in [brackets] at the beginning, like so: [Potato Adventures] - Chapter 1: The Great Mashing Please help us transition to using the new flairs correctly. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral1
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u/AutoModeratorThis was flaired as [OC-Series], it is a single part or chapter in a larger series or universe. The first post or part in this series should be (re)flaired as [OC-FirstOfSeries]. A description of the flairs and how to change yours is available in the Post Guildelines. [OC-Series] For original, self post, story, audio, or artwork that you have created, as part of a longer-running series or universe. Our preferred series title format is the series title in [brackets] at the beginning, like so: [Potato Adventures] - Chapter 1: The Great Mashing Please help us transition to using the new flairs correctly. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral
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13r/microbiomenewsFasting primes small intestinal regeneration after damage via a microbiome–metab...basmwklz1090%57.9induced pluripotent stem cells2026-03-30↗
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14r/DebateEvolutionHow tweaking genes that control embryonic development can lead to the evolution ...Benjamin5431320%356.1induced pluripotent stem cells2026-03-04↗
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u/junegoesaround5689Great mini-lecture on evo-devo.positive3
u/Academic_Sea3929It's amazing that creationists never bother to look at how development works. It's clear that they are assuming (always implicitly, never explicitly) that many new genes are required for new body parts/plans, but they very clearly aren't.negative2
u/Coolbeans_99Very cool, i’ll have to read it over a few timespositive1
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15r/ketoscienceAspartame exacerbates cerebral ischemia–reperfusion injury via mitochondrial dys...basmwklz200%555.8induced pluripotent stem cells2026-03-08↗
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u/DoctorHathawayThat it! I will not be giving my pet mice any more Diet Coke, no matter how much they protest!!positive8
u/ridicalisAlmost made me spit out my Zero Sugar Dr Pepper. I already took erythritol out of the diet recently due to the possible cardiovascular implications. You dropped that bit about sorbitol not too long ago. I can live without sweets, but it's becoming increasingly difficult to find a sweetener that isn't problematic.negative1
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16r/ScienceOdyssey✨️ Japan is leading with policies around pluripotent stem cells, accelerating re...Purple_Dust57345710%353.6induced pluripotent stem cells2026-03-30↗
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u/Diawara57This is really exciting stuff! We've been hearing about the potential of stem cells for 3 decades or more now, and it seems like this is a huge breakthrough that can help many. Awesome!!positive4
u/messangerchknI dont trust capitalist medicine anymore. Cuba wouldve figured this out 40 years ago without the embargonegative1
u/Neil_HillistWhat could go wrong ? ... https://www.nejm.org/doi/full/10.1056/NEJMc1600188 ?neutral
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17r/OptimistsUniteStem Cell Therapies "Come of Age" with Approvals in JapanCrabbexx340%52.8induced pluripotent stem cells2026-03-12↗
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18r/ParkinsonsTruStem cell therapyAware-Drawing-542680%652.4induced pluripotent stem cells2026-03-13↗
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u/Ill-Lavishness4274Look, the stem cells showing promise in PD trials right now are very different from what these clinics offer. The real work being done by real biotech companies like BlueRock, Sumitomo, and Aspen involves specialized cells that require serious neurosurgery to reach the right part of the brain. Clinics like TruStem just do basic infusions, which have no evidence behind them for Parkinson's. I know the current trials exclude DBS patients, but that’s standard for testing (they exclude lots of stuff like diabetes or psoriasis even). It doesn't mean the therapy won't be available to you once it’s approved. Things are moving fast, so please don't risk it with these shady clinics. They aren't a shortcut, they’re just a distraction from the real science.positive12
u/Intelligent-Will-913I read somewhere that Japan is rolling out stem cell technology in the summertime for those with Parkinson’s..neutral5
u/IllustriousTonight82Last year I watched a webinar with several scientists on michaeljfox.org that discussed this at length. As Ill-Lavishness4274 said in their post, there is no evidence that stem cell infusions are effective treatments for PD. True stem cell therapy that is being studied in clinical trials involves brain surgery.neutral5
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19r/Neet_indianeed help w this questionIcy_Money496150%1152.3induced pluripotent stem cells2026-03-14↗
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u/SquirrelEconomy5315B hi toh ayega polar movement toh light ki presence mai hoti hai, online search karo iske bare mai image se samajh aa jayeganeutral3
u/Majestic-Concert6634a is the answer. the movement of auxin to cut side leads to its isolationneutral3
u/CapSensitive5509I think it should be A, as the movements were recorded by Darwin and his son, while this guy isolated auxins from tips of oat seedling or smthneutral2
u/takli_billiI think d, explanation for b? ?negative1
u/[deleted]Bneutral1
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20r/WeLoveYouCaineAm I Crazy or Alone?OriginalHell100%452.0induced pluripotent stem cells2026-03-26↗
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u/Maximum_Effective66it’s too late for my brain to process all of this, but get into it /gen /pospositive6
u/ZealousidealDrop365Holy yapfest (I say that lovingly)positive5
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21r/InterstellarKineticsSildenafil, The Active Ingredient In Viagra, Has Just Slowed A Deadly Childhood ...InterstellarKinetics100%351.1induced pluripotent stem cells2026-03-31↗
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u/InterstellarKineticsTurning an erectile‑dysfunction drug into a life‑extending therapy for dying children is the kind of “repurposing” story that will resonate strongly with a general audience. The key detail to emphasize in comments is that sildenafil does not cure Leigh syndrome. What it appears to do is buy time and function by partially rescuing energy metabolism in neurons, giving affected kids more mobility, fewer seizures, and relief from the terrifying metabolic crises that can suddenly worsen the disease. That is still a massive change when the baseline is rapid neurodegeneration and early death. The orphan‑drug status and the planned SIMPATHIC trial are the concrete follow‑up milestones that will determine whether this becomes a standard treatment or remains a promising but niche intervention.positive1
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22r/ATHXJapan officially becomes the first country in the world to approve iPS cell-deri...imz7250%650.3induced pluripotent stem cells2026-03-06↗
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u/imz72Japan approves world‑first iPS cell drugs for summer release March 6, 2026 Japan has formally approved the world’s first regenerative medical products utilizing induced pluripotent stem (iPS) cells, paving the way for use in patients as early as this summer. Health Minister Kenichiro Ueno granted approval for the two products on March 6 under a fast-track provisional certification system. They mark the world’s first practical use of medical treatments derived from iPS cells. The approved drugs are ReHeart, developed by the Osaka University–originated venture Cuorips Inc., for the treatment of severe heart failure, and Amchepry, a neural cell therapy, developed by Sumitomo Pharma Co., for the treatment of Parkinson’s disease. Both products use third‑party iPS cells stocked by the CiRA Foundation, which was established by Kyoto University. With the drugs now approved, prices will be set and will be authorized for use in treatments covered by the national health insurance system. For regenerative medical products, drug prices are generally determined within four to five months after approval. The treatments using these drugs could be available for patients as early as this summer. Both products were approved under the conditional and time‑limited approval system, which is designed to deliver regenerative medical products to patients as quickly as possible. This system is a kind of provisional license, allowing safety and efficacy to be assessed using data from fewer patients than is required for clinical trials of conventional drugs. For this reason, companies are required to study treatment outcomes during the seven‑year period following the start of sales and obtain “full approval” after reassessing efficacy and other factors. ReHeart will be assessed under the treatment of 75 patients and Amchepry for 35 patients, including 30 who are 65 or younger. The clinical outcomes of all patients who are treated using these products will be examined. The iPS cell was created by Shinya Yamanaka, a professor at Kyoto University, who received the Nobel Prize in Physiology or Medicine in 2012 for his groundbreaking work with iPS cells. This year marks the 20th anniversary since Yamanaka first generated iPS cells using mice in 2006. [Source: The Asahi Shimbun] Health Minister Ueno Kenichiro said after a Cabinet meeting on Friday that he hopes patients in Japan and throughout the world will be helped. He added that the necessary procedures will be moved forward so the treatments can quickly reach all patients. https://www3.nhk.or.jp/nhkworld/en/news/20260306_17/positive1
u/wood999999I see your still around. Grahamneutral1
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23r/AdultCHDPeptides, stem cells and heart diseaseK00paa2430%949.4induced pluripotent stem cells2026-03-05↗
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u/calicaliWhere are you reading these things? It's not FDA approved and never been through proper human trials. The only "results" I can find are sketchy supplement ecomm storefronts, Medspas and unqualified influencers who are also selling the peptides direct from China. Did you discuss this with your doctor? This sounds like an absolutely terrible idea that will cause you harm. You hone in on your heart health by regular exercise, eating healthy balanced meals, improving your sleep quality, managing your stress, etc. You do not improve your health by taking snake oil. Please talk to a qualified physician who is aware of your heart condition. ?negative5
u/jakemalonyBPC-157 shows promising cardioprotective effects in rodent models, particularly for doxorubicin-induced damage and post-MI recovery, but human cardiac data remains limited. For your sternal healing specifically, it has more established anecdotal support in orthopedic and surgical recovery contexts. Given your recent second open-heart surgery at 34, I'd prioritize discussing BPC-157 with your cardiothoracic team rather than self-administering post-surgical tissue in the sternum is mechanically and vascularly complex, and healing timelines vary widely even without intervention. Stem cells for cardiac regeneration are still largely investigational; most legitimate programs are clinical trials with strict inclusion criteria, not cash-pay clinics. Your energy might be better directed toward cardiac rehab completion, inflammation management, and patience with sternal union, which can take 3-6+ months. If you do explore BPC-157, oral or localized subQ near the sternum would be the logical application, not systemic use for cardiac remodeling.neutral2
u/Pirate_Of_HeartsSternal pain after surgery is normal. Jumping to experimental treatments is a bit of a leap. Have you spoken to your physician about pain management and typical recovery time? Also, you're probably still in cardiac rehab, correct? If not or your doctor didn't sign you up for it, ask about it. It's PT specifically for after open heart surgery. ?neutral2
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24r/AvascularNecrosisAVN of talusManyArm242620%1248.6induced pluripotent stem cells2026-03-18↗
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u/Mysterious-Belt-2992Yes! Me! I was 18 when I got my kidney transplant and all that prednisone gave me AVN in both Talus. I got leg braces made I started college and guys were carrying me to class 😂 BUT! They repaired themselves and got their vascular activity back! That was 25 years ago! And while is still have AVN in my left hip, with collapsed femoral head, it’s not too bad! I have put off getting it replaced. I can wear heels 👠 for a couple hours lol. Funny that’s how we gage our bone disease as women 😅positive2
u/coldjesusbeerSimilar experience. Got diagnosed with AVN of the tibia, talus, and heel. Went non-weight-bearing in a boot for the better part of 6 months per doctor's orders. The pain went from challenging to excruciating after the boot. Doctors told me there was nothing they could do for me. Stopped the boot entirely. Started getting back on my bike and becoming physically active again. Moved to NYC where I walk everywhere. Daily pain is gone 3 years later. I wear heels again. Gotta be careful walking down hills or carrying my bike downstairs, but other than that, I have my life back.negative2
u/showmenemeldaI knew time travel was real! Tell me, is 2038 better?! ?positive1
u/Mysterious-Belt-2992I know you mean 2017, right? ?neutral1
u/mangoawaynowwait can i DM you? I wanted to ask some questions because both of my ankles are cooked 🥲 and not hella people have it in the talus bone ?negative1
u/radicalelkFellow talus AVN gal 👋🏼 mine is from an injury though. I got my debridement in September, they did a Brostrom repair for instability at the same time. I do NOT regret the debridement - that deep shocking pain is near gone! However I do regret the brostrom repair. My ankle is still significantly swollen, and 2 miles is my limit for walks still (though I can lift!). Hoping for some relief there in the coming months. Surgeon suggested a full year is needed for bounce back. Anyways, thank you for sharing your story. My original doctor also gave me my diagnosis very grimly. It has been such an odd experience.positive1
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25r/stemcellsHopstem BioPlusSheepherder727340%448.0induced pluripotent stem cells2026-03-06↗
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u/Primary-Ruin8830I’ve been keeping a close watch on AKUUGO. Crossed fingers that it quickly becomes available to the public.positive2
u/Primary-Ruin8830I am wondering if this will also be a good treatment for a traumatic brain injury. It presents very similar to a stroke.neutral1
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26r/immortalistsAgeing and the Chimera Sapien_Rumpelstilzchen_110%47.9induced pluripotent stem cells2026-03-11↗
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27r/pluribustvpsychopaths guide to defeating the hiveFrost-Flower0%2047.3induced pluripotent stem cells2026-03-11↗
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u/TheAzureMageIt is unlikely the immunity is hereditary. There are already children of immune who are part of the hive. There's no need for some elaborate effort to test this when it's already known from the first meeting of the immune. The immune are all unrelated to one another. It's definitely something else.neutral11
u/Glowing_Trash_PandaThis just seems like some overly elaborate way to try to excuse a pregnancy fetish….negative11
u/AC20212020Oh, good, another 'Carol is stupid,' post. After the initial shock of humanity getting converted I would sit down with the hive to properly discuss the specifics of how the hive works but unlike Carol I would be more thorough; asking questions like: "what happens if two humans give contradictory requests" or "what is the degree of risk the hive is willing to take when it comes to harming life" What is the point of those? They'd say it depends. Next I would request one pregnant hiver and impregnate one myself to keep in containment at my base, I would conduct research into curing the hive-infected for the next 9 months. In the meantime I would try to induce two of the 13 immune individuals to start a family among themselves or with me. From there 5 possibilities exist: .... Wtf 2.The hive comes too close to finding a way to infect us before 9 months. In this case I request 200 women within the fertility window to be placed in my prison. Afterward I arrange a meeting with the other 13 humans under the guise of a celebration for a holiday and knock them out using poison or gas during it (this is a very risk endeavour that needs be planned carefully and I may have to personally kill some of the remaning humans). Once the 200 hivers and 13 humans are imprisoned I place the hivers in a medical coma within the prison and scream at one of them until they are knocked out and I keep screaming at them for 3 days straight until all the ones except I kept are dead from dehydration. From there the plan will follow the next possibility. So it's a fully creepy fetish slave breeder post. Ok then. Also, the idea that explaining basic genetics will allow you to do genetic research and place people in medical comas and start your own breeding harem is... I give, backing out of the fetish post.negative6
u/JoeIntTheBoxThe hive foils me or there truly is no cure. In this case we are boned. There probably is a "cure" or a way to block the signal, which is what Manousos is working on. A lot of your plans hinges on months, maybe years of prep and work. Carol only has weeks before they find a way to infect her. They will get you before you can successfully get them. A quicker route that may buy everyone more time, is finding a way to block the infections first, before finding an actual cure.negative3
u/AvanchnzelI keep screaming at them for 3 days straight until all the ones except I kept are dead from dehydration 🤣 In order to save my throat I'd probably first try to blast them with a recording of terrifying screams 24/7. But if it's only face-to-face screaming that riggers their emotional seizures, then I'm not quite sure you could do that alone. Depending on how long the seizures last, you'd probably have to scream at them every few minutes. How would you do that for 3 days straight? You'd have to train yourself to do a polyphasic sleep schedule. But even with that you'd have to have at least 20 minutes of sleep, any shorter doesn't really work reliably and you'll probably miss wake-ups or have narcoleptic episodes. Since you need to scream every few minutes, this just wouldn't work. Are there alternative ways you think you could kill everyone of the hive (except for your prisoners)?negative3
u/BoingBoingBootyWhy not just ask where the best bunker in the world is. One that they couldnt get to. Take me there. Build a prison cell for me. Ok were going to do segs put these chains on. Wait while i lock down the bunker. Scream at them for hours. Wipe the bastards out. If carol and manus worked in shifts they could go untill most die of thirst. Demanding terms on day two or three would probably trigger there survival protocols. Maybe you could get some power sharing agreement where they teach you to unplurb some so all plurbs dont die.negative2
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28r/IBSResearchMicrobiota-derived extracellular vesicles mediate gut-brain axis dysfunction in ...jmct1680%46.5induced pluripotent stem cells2026-03-29↗
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29r/saudimedicalخلايا جذعية بين الأمل الطبي والجدل الأخلاقي… رأيكم؟Peachy700220%545.8induced pluripotent stem cells2026-03-29↗
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u/everglow_33انا اشتغل على خلايا جذعية والموضوع تغير، في عالم اسمه ياماناكا اكتشف طريقة كيف نرجع خلايا بالغة لوضعها القديم وفاز بنوبل ٢٠١٢ وهي الطريقة الحديثة الي نستخدمها الحين بدال ما نستخدم من اجنة او من شخص ثاني نستخدم من الشخص نفسه. ما اعرف اذا تطبق بالمستشفيات او لسا لكن شغالين عليها في المعاملpositive2
u/heba759الصدق عن نفسي اي اذا ما انزرعت فيه الروحneutral1
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30r/OnenessMovementSexuality, Creation, and Expansion of Consciousness: Web of Life (Part 4A)AuroraCollectiveV20%445.0induced pluripotent stem cells2026-03-06↗
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u/rebb_hosarThis was incredible and mirrors the internal struggle I've been trying to contend with for over a decade. In truth, while having not eaten meat and while taking personal responsibility for the effect of my excesses as a human, I feel the pressure seems to compound. It's akin to a type of world empathy which feels as though one is existentially being burned alive. I find that our destructive pattern of consumption and destruction just may be who we are. What is the function of a singular, reluctant, self-aware cancer cell or virus? Can it only stop and observe in horror?positive1
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31r/IndicKnowledgeSystemsThe Pioneering Journey of Ramamoorthy Ramesh: Innovator in Complex Functional Ox...Positive_Hat_541450%44.5induced pluripotent stem cells2026-03-26↗
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32r/OncologyThe Role of Cytokines and Chemokines in Pre-metastatic NichesNerdfighter33350%44.5induced pluripotent stem cells2026-03-17↗
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33r/ATHXSumitomo's iPSC product for Parkinson's: listing for reimbursement by June; 1st ...imz7230%244.5induced pluripotent stem cells2026-03-09↗
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u/imz72Machine-translated from Japanese: March 9, 2026 Sumitomo Pharma and Sumitomo Chemical provide financial and human resources support for the parent-child bond that supported iPS drug approval Sumitomo Pharma has received approval to manufacture and sell a regenerative medicine product using iPS cells. It took more than 10 years for the company to fully launch its iPS drug discovery business, which began in 2013. Despite facing a funding shortfall after the patent expiration of its flagship drug, the company was able to secure approval thanks to the support of the entire group from its parent company, Sumitomo Chemical. "Our focus is on small molecule drug discovery, and there were some internal doubts about whether regenerative medicine could really be achieved. With this approval, we are now confident that the entire company can work together," said Sumitomo Pharma President Toru Kimura emphatically at a press conference on March 6. "We are the first in the world to commercialize pharmaceuticals derived from iPS cells, which can differentiate into any cell type in the body. Amchepry, a neuronal cell line for Parkinson's disease, is surgically transplanted into the brain to compensate for lost neuronal function. Our goal is to provide a fundamental cure, rather than simply suppress the progression of symptoms." This approval is conditional and time-limited. The company aims to obtain further data on efficacy and safety during the seven-year approval period before submitting a formal application. The first patient could be transplanted as early as the end of 2026. Professor Yamanaka joined the company the year after winning the Nobel Prize Sumitomo Pharma established a specialized department in 2013 and entered the iPS drug discovery business. The previous year, Professor Shinya Yamanaka of Kyoto University, who developed iPS cells, had won the Nobel Prize. Sumitomo Pharma (then known as Sumitomo Dainippon Pharma) had focused on small molecule drugs for the nervous system and cancer, but saw potential for growth in this field. In 2014, the company opened the Regenerative and Cellular Medicine Kobe Center in Kobe, and in 2018, it began operating the manufacturing plant SMaRT. The COVID-19 pandemic, which began in earnest in 2020, cast a dark cloud over the development plan. Clinical trials that had begun in 2018 were delayed. Discussions with the Pharmaceuticals and Medical Devices Agency (PMDA), the review authority, then ran into difficulties over the interpretation of clinical trial data based on a small number of cases. Financial difficulties also arose. In 2023, the patent for its mainstay schizophrenia drug, Latuda, expired in the United States. As business performance deteriorated significantly, research and development expenses, which had exceeded 90 billion yen in the fiscal year ending March 2024, were halved. Nevertheless, the company continued to invest around 10 billion yen [$63 million] annually in its regenerative medicine and cellular medicine business. Sumitomo Chemical was the driving force behind this. In 2024, Sumitomo Pharma spun off its regenerative medicine and cellular medicine business and established a joint venture with Sumitomo Chemical called "Racthera." While most of the personnel responsible for development were provided by Sumitomo Pharma, Sumitomo Chemical invested approximately two-thirds of the capital. The manufacturing base was also transferred to another joint venture called "S-RACMO," creating a system in which the entire group could provide support. It was not an easy decision for Sumitomo Chemical either. In addition to the deteriorating performance of Sumitomo Pharma, the company's petrochemical business was also struggling, resulting in a final deficit of over 300 billion yen [$1.9 billion] for the fiscal year ending March 2024. There is still talk of selling Sumitomo Pharma or partnering with another company. The reason for the continued support is that it will enable the group to utilize its collective strength and is expected to be a driver of future growth. At a press conference on March 6, Sumitomo Chemical President Nobuaki Mito emphasized that he would like to develop iPS medicine as "one of the pillars of the group." "Sumitomo Chemical conducted research on regenerative cells in the early 2000s, and many of the researchers involved at that time are also active in this project. We will mobilize all of our group's resources to work towards the final goal," he said. To evaluate the safety of chemicals on the human body, the company has been working on research into using embryonic stem cells (ES cells) as an alternative. Amchepry still has a long way to go before it can become profitable. Kimura acknowledges that "there will be almost no impact on our business performance over the next few years, and in fact, research and development costs for clinical trials will increase." The Japanese market is positioned as a place to build a track record. Thpositive1
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34r/Scholar[Article] Mesenchymal Stem Cell-Derived Exosome miR-153-3 Induced M2-Type Polari...Previous_School_868430%244.5induced pluripotent stem cells2026-03-15↗
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u/Dapper_Rub1822https://send.now/4z6iyqajronnneutral1
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35r/systemictendinitisLithium and B12 Injections as a potential treatment for post-accutane induced te...Zodianz40%143.5induced pluripotent stem cells2026-03-30↗
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u/Effective-Rice-3732I'm curious of supplementing lithium ortate would helpneutral1
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36r/NovosLabsWhy the ageing immune system may help drive body-wide ageingNovosLabs40%43.5induced pluripotent stem cells2026-04-02↗
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37r/ATHXPhase 1/2 trial for Parkinson's using iPS cells underway in the USimz7220%242.8induced pluripotent stem cells2026-03-28↗
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u/imz72BTW, Saisei Ventures, which is a subsidiary of Healios, is one of the seed investors of Kenai Therapeutics, as is shown in the presentation: https://youtu.be/mUMLUZchAJw?t=693 and on Saisei's website: https://www.saiseiventures.com/portfolio/ Gemini says: Saisei Ventures is listed as a participating investor in Kenai Therapeutics' $82 million Series A financing round, which was announced in early 2024 (and is a primary part of the company's total funding of approximately $89 million as of 2026). This round was co-led by the Alaska Permanent Fund Corporation, Cure Ventures, and The Column Group, with Saisei Ventures and Euclidean Capital also participating. Regarding the exact percentage of ownership, this information is not publicly available. As a private biotechnology company, Kenai Therapeutics is not required to disclose the specific cap table (the breakdown of who owns how much) or the individual equity stakes held by its venture capital partners. In the venture capital industry, these details are typically kept confidential between the company and its investors. ?neutral1
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38r/ATHXThe MultiStem stroke trials mentioned in a Chinese studyimz7230%142.3induced pluripotent stem cells2026-03-25↗
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39r/NeuronsToNirvanaAbstract; 🧬⚡ N2N Insight Brief 🔬🌀| Psilocin fosters neuroplasticity in iPSC-deri...NeuronsToNirvana30%42.3induced pluripotent stem cells2026-03-29↗
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40r/ATHXAstellas President: Regenerative medicine in Japan has entered a new phase with ...imz7230%142.3induced pluripotent stem cells2026-03-30↗
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41r/IndicKnowledgeSystemsThe Trembling Reed: Poison, Rain, and the Sacred Art of Arrow-Tempering in Vasis...Positive_Hat_541430%42.3induced pluripotent stem cells2026-03-23↗
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42r/AskDocsLikelihood of gallstones 9 years after a lap chole?throwra_103550210%442.0induced pluripotent stem cells2026-03-29↗
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u/Puzzled-Science-1870It's possible but rare. Sometimes people rarely form gallstones in their bile ducts even after cholecystectomy. I'd get an MRCP to prove no bile duct stones, and if not, then it's most likely your alcohol use. Your alcohol use is more likely to be the cause of the pancreatitis, but not a bad idea to rule out residual stones. All the best.neutral1
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43r/TargetedSolutionsMind Control Tech w/ ReferencesSouthern_log56710%442.0induced pluripotent stem cells2026-03-15↗
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u/Bryan_TewUnderstanding the memory attacks (blocking your real memories & injecting false memories & motivational impulses) are key because if you do not recognize modification of your ‘active memory’ the system will cause you to briefly lose time perception which may be enough procedural [functional] disorientation to influence you to respond to an injected impulse or memory attack! It is possible for the RNM system to influence you to speak or act unwillingly or, at the very worst, without you knowing it. For example, if you are susceptible to the systems influences you may not realize that it is frequently or constantly influencing you to make minor choices. These motivational impulses can also be used to influence you in a manner that will give you the desire to speak, and I emphasize desire because you need to understand that these impulses will only make you feel the urge [at higher levels set by the attackers] or basic motivation [at baseline levels] to perform the tasks it is influencing you to do Now in combination with this motivation to speak or act the A I system uses past memory references to direct you ­ for example, your personal memory of turning to speak to your wife & the associated impulse ­& when you react to this influence the system will block your working memory while streaming the desired output which will result in you making one or more statements under the system’s control They will test this on you frequently with ‘word substitution’ and if you can learn to control this in thought then you can control it while speaking but you must learn to read active memory If you cannot recognize modification of your active memory then after the forced speech attack it is possible that you will have no recollection of making the statement As you learn to defeat the predictive capabilities of the system by reading active memory (testing and validating your own thoughts) you will see their attempts to restrict your ‘reference choices’ will become increasingly evident and you will begin to perceive what I will describe as ‘functional duality’ [it might also be described as focal duality] within your working memory. The perps system’s prediction error rate will dramatically increase & its attempts to predict your thoughts or intentions will become humorous if not simply annoying Seeing the relationship between your own previous memory references and the systems output [which can be a specific memory or emotion previously captured by the RNM System and now replayed perpetually in your mind] is critical to understanding how to control & ultimately defeat ‘thought­ triggered’ attacks in addition to preventing the attackers from deceiving & manipulating you You should be able to redirect the system during ‘Formulation’ (collecting data by reading your mind) or prevent ‘Predictive Integration’ (interpretation of data from injected thoughts & impulses) altogether, but when you learn to stop integration, realize that the system will be waiting for completion & will ‘probe’ you for a response. It will begin to ‘inject’ again if you attempt to ignore it If successful , you will notice they will also abuse you in every way possible to convince you that they’re in control when you will be able to see clearly that they are nothing more than idiots who need to spend more time studying the systems they are abusing people with If the system’s suggestions are not acceptable to you [and they won’t be if you’re consistently blocking and/or redirecting it] then this will result in you making a continuous effort to counter the imposition of thoughts and impulses while contrasting you’re ‘working state’ to maintain active focus Although by cooperating & allowing the system to interpret & define your daily activity you may find that the suggestions become more tolerable as the system is designed to mimic your normal cognitive behavior, I would recommend not allowing this as you will tend to more readily accept the system’s influence, and the purpose of the system influencing you in this manner is to give the attackers the ability to restrict you at will & to allow them to deceive or manipulate you subconsciously You can only counter these restrictions if you are able to contrast the system’s influence from your own willful activity. Everyone who is hearing “V2K” is being monitored in this manner & being influenced in this way as well. The phrases you are hearing should be related to information captured during the ‘silent monitoring period’ & will eventually be used as the foundation for your endless verbal harassment What they do is a game of deception & manipulation, nothing more. Do not accept anything they say as truth & do not acknowledge anything the system interrogates you about as truth. The system will take random bits of anything it captures through your senses & fabricate stories which they will use to harass & interrogate you with no intention other than to distract & torture you into submission [to the sneutral2
u/Southern_log567⁠⁠⁠⁠Allan Frey – Microwave Auditory Effect 🔗 https://en.wikipedia.org/wiki/Microwave_auditory_effect ⁠⁠⁠⁠Pentagon Heartbeat Laser (remote biometrics) 🔗 https://www.technologyreview.com/2019/06/27/238884/the-pentagon-has-a-laser-that-can-identify-people-from-a-distanceby-their-heartbeat/ ⁠⁠⁠⁠New World Vistas – USAF Science 1994 (see pgs. 88–100) 🔗 https://apps.dtic.mil/sti/tr/pdf/ADA309597.pdf ⁠⁠⁠⁠Canadian Government – Havana Syndrome transparency 🔗 https://www.international.gc.ca/transparency-transparence/unexplained-havana-incidents-inexpliques-la-havane.aspx?lang=eng ⁠⁠⁠⁠Balaban et al. 2020 – Eye movement biomarkers in Havana Syndrome 🔗 https://pubmed.ncbi.nlm.nih.gov/32655474/ ⁠⁠⁠⁠MRI usage statistics in Canada 🔗 https://www.ncbi.nlm.nih.gov/books/NBK607341/ ⁠⁠⁠⁠JAMA – MRI Imaging studies on gray/white matter changes 🔗 https://jamanetwork.com/journals/jama/fullarticle/2738552 ⁠⁠⁠⁠John Norseen & Duncan Laurie – Biofusion neuroweapon theory 🔗 https://www.duncanlaurie.com/writing/outlaw_technology/03_krylov_space ⁠⁠⁠⁠Retina as a biological antenna (ResearchGate) 🔗 https://www.researchgate.net/publication/336408771_Fractal_and_periodical_biological_antennas_Hidden_topologies_in_DNA_wasps_and_retina_in_the_eye ⁠⁠⁠⁠Cavity resonators and quantum frequency generation 🔗 https://www.sciencedirect.com/science/article/abs/pii/0370269379902272 ⁠⁠⁠⁠Cavity resonators and quantum frequency generation 🔗 https://www.sciencedirect.com/science/article/abs/pii/0370269379902272 ⁠⁠⁠⁠Microtubules – Structure and function 🔗 https://en.wikipedia.org/wiki/Microtubule ⁠⁠⁠⁠Quantum Entanglement – Basic overview 🔗 https://en.wikipedia.org/wiki/Quantum_entanglement ⁠⁠⁠⁠Remote NIRS (Near-Infrared Spectroscopy) for brain monitoring 🔗 https://pubmed.ncbi.nlm.nih.gov/36965063/ ⁠⁠⁠⁠Geostationary IR/NIR imaging applications 🔗 https://pubmed.ncbi.nlm.nih.gov/34335997/ ⁠⁠⁠⁠Cosic (2017) – Resonant Recognition Model (Tesla bioresonance) 🔗 https://www.researchgate.net/publication/318306399_Tesla_Bioresonances_and_Resonant_Recognition_Model ⁠⁠⁠⁠Caceres (2018) – Zika virus and RRM 🔗 https://www.researchgate.net/publication/330748880_Zika_Virus_Viewed_Through_the_Resonant_Recognition_Model_Unraveling_New_Avenues_for_Understanding_and_Managing_a_Serious_Threat ⁠⁠⁠⁠Photon entanglement through brain tissue 🔗 https://www.academia.edu/30547093/Photon_Entanglement_Through_Brain_Tissue ⁠⁠⁠⁠Measuring protein concentrations with entangled photons 🔗 https://www.academia.edu/60782774/Measuring_protein_concentration_with_entangled_photons ⁠⁠⁠⁠Persinger – Thixotropic water properties and EM field interaction 🔗 https://www.mdpi.com/1099-4300/17/9/6200 ⁠⁠⁠⁠Resonance modeling of JAK–STAT signaling (Persinger 2015) 🔗 https://www.researchgate.net/publication/274096152_Novel_Cosic_resonance_standing_wave_solutions_for_components_of_the_JAK-STAT_cellular_signaling_pathway_A_convergence_of_spectral_density_profiles ⁠⁠⁠⁠Entangled photons for quantum communication & measurement 🔗 https://www.academia.edu/73224923/Quantum_entangle_photon_and_applications_in_communication_and_measurement ⁠⁠⁠⁠Cryogenic microwave pulse generator for superconducting quantum computing 🔗 https://www.researchgate.net/publication/382296421_A_cryogenic_on-chip_microwave_pulse_generator_for_large-scale_superconducting_quantum_computing ⁠⁠⁠⁠Dr. James Giordano – Neurowarfare lecture (YouTube) 🔗 https://www.youtube.com/watch?v=N02SK9yd60s&t=1276s ⁠⁠⁠⁠The Unspoken Arms Race: Neurowarfare 🔗 https://www.researchgate.net/publication/355348195_The_Unspoken_Arms_Race_Neurowarfareneutral1
u/DribblingJonGood work. But seriously.  The mechanisms behind this shouldn't matter. The governments of the world are litterally ignoring tens of thousands of people reporting the exact same thing. I even have stuff like two of my friends mysteriously developing these voices at the same time as I did. Then the voices told them stuff like "Go pick up Bradley" at the same time as I was told "Your friends will be here in 30 minutes to pick you up." Unfortunately that's our word against hundreds of years of medical science saying "hearing voices means you're losing it." Yet I have this corroborated thing, that if true would be the largest human rights violation of all time that causes so many people so much suffering. Puts us through hell. Yet they just ignore it.negative1
u/targeting_CameronI have been getting an oily substance coming out of both eyes lately. Do I go to the dr.? ?negative1
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44r/UPSCmosquito mention krna bhul gye lolsnoe_lungcancer220%541.2induced pluripotent stem cells2026-03-08↗
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u/mitchellwolverineToxic males are in demand everywherenegative8
u/Wise_Shake_5630They know what they’re doing 😌positive2
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45r/ATHXJapan's Teijin to offer personal iPS service with production cost of $63Kimz7210%341.1induced pluripotent stem cells2026-03-17↗
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u/imz72March 17, 2026 Personal iPSC Service to Launch with Production Cost in the 10-Million-Yen Range ... Fees will initially consist of the manufacturing cost — set in the 10-million-yen range — plus separate storage charges depending on the duration. The partners aim to bring prices down over time through operational efficiencies. The companies target 20 orders in FY2026 and 1,000 by FY2030, equivalent to sales of roughly 10 billion yen [$63 million]. ... The service targets individuals — both in and outside Japan — willing to invest heavily in personal health. Nakagawa said the service could gain traction particularly in multi-ethnic markets such as the US, where differences in HLA types can make matching donor-derived iPSCs more difficult. Nakagawa noted that the new pricing marks a sharp drop from earlier estimates of around 50 million yen [$315K] for producing autologous iPSCs. Even so, Teijin Regenet President Yasushi Tanaka acknowledged the cost remains “somewhat high” for private individuals, saying the companies will work to reduce prices through automation and labor-saving manufacturing systems. Nakagawa added that advances in manufacturing know-how, economies of scale, and automated quality-controlled processes should also help lower costs over time. https://pj.jiho.jp/article/254973neutral1
u/imz72And 2 short videos from a Chilean TV channel, which can be viewed with English dubbing and subtitles: March 17, 2026 Japan authorizes the first regenerative therapy for Parkinson's disease using pluripotent cells https://youtu.be/QCyz6xFs0kA Innovative stem cell therapy for Parkinson's disease presented https://youtu.be/7ZXo9_SmLVcneutral1
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46r/u/pytersdmfThe Living Lens: How Regenerative Medicine is Rebuilding the Windows to Our Worl...pytersdmf20%40.5induced pluripotent stem cells2026-03-13↗
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47r/radicalmentalhealth"What If the U.K. Had Free Speech?" + 30 articlesReferendumAutonomic20%40.5induced pluripotent stem cells2026-04-03↗
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48r/PICLHello Dr. Centeno!Rare-Lingonberry-18220%140.5induced pluripotent stem cells2026-03-17↗
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u/Chris45782199% of the time, things that work in rabbits don't work in people, so we will have to see how that plays out. The key piece of disc height is actually GAGs which hold onto water, so based on that, this will likely not be that effective.neutral1
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49r/HumanMicrobiomeThe top new and updated threads in the last week on the Human Microbiome ForumAutoModerator20%140.5induced pluripotent stem cells2026-03-09↗
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u/AutoModeratorReddit is no longer a reliable place to create, host, and grow communities, so a new microbiome forum has been set up to be a more reliable location. If you have posted content on Reddit that you feel is worth preserving, it would be a good idea to post it on the new forum. The person who created this sub, and most of the content here, including the wiki, has moved to the new forum. You should be able to get better info & answers there. It's easy to stay on reddit but the quality of content on most subs is extremely poor. Most of the advice given on reddit is misinformation. You're welcome to post your content there and then link to it here for higher visibility. Our primary goal will remain as stopping the widespread misinformation on the topic of the microbiome. Since we no longer have someone dedicated to correcting and preventing misinformation, comments and posts here will require pre-approval. Some types of content (questions) may be restricted completely since we no longer have reliable people dedicated to providing evidence-based answers. But you're welcome to ask your questions on the new forum and post the link here. I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.negative
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50r/GCSEAQA Biology mark schemeAdditional_Low_8410%239.8induced pluripotent stem cells2026-04-02↗
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u/PureBelt8770bracket r just extra info - not mandatory - its jst context of the questionneutral1
u/Legitimate_Yam3395Brackets mean extra info not necessarynegative1
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51r/ProductivitycafeAudifort Reviews and ComplaintS:~ An Honest Customer 2026 Review!Practical-songs10%239.8induced pluripotent stem cells2026-03-14↗
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u/whitswhisperear fatigue from late night podcasts is already creeping in at my age. Solid breakdown, might stack this to keep focus locked during study grindsneutral1
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52r/NooTopicsCan adult neurogenesis be done in order parts of the brain with this strat? (A n...makefriends420170%338.3induced pluripotent stem cells2026-03-03↗
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u/makefriends420Ultimately, this work has demonstrated an improved protocol for generating all major hippocampal subtypes from hPSCs. Not only does this approach generate the longelusive CA1 subtype that has been missing from previous protocols, but the method is able to produce region-specific astrocytes. The rich electrophysiological properties of the neural cultures were found to be sensitive to morphology (monolayer vs organoid) and astrocyte to neuron ratio. While significant work remains to elucidate the complex workings of the hippocampus, the individual cell types, and understand inter-region interactions, the ability to culture a more diverse array of neural subtypes will be an invaluable tool for future research.positive3
u/grokon123Explain like I’m retarded. What’s the protocol? ?negative1
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53r/ProactiveHealthJapan just approved the world’s first treatments made from reprogrammed human ce...DadStrengthDaily10%37.5induced pluripotent stem cells2026-03-14↗
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54r/Scholar[Article] Comparative Histological and Immunohistochemical Study on the Effect o...rimeldemiel1310%37.5induced pluripotent stem cells2026-03-14↗
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55r/KeltoiWellnessThe 6 most important lessons about belly fat (and how to lose it)markoj2210%37.5induced pluripotent stem cells2026-03-25↗
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56r/PennystockCBD Life Sciences Inc. (CBDL) Announces CBG Emerges as a Promising Focus in Canc...louied9110%37.5induced pluripotent stem cells2026-03-24↗
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57r/RNStudentResourcesWGU D027 - Advanced Pathopharmacological Foundations OA 1st Attempt 2026.CertifiedRN10110%37.5induced pluripotent stem cells2026-03-18↗
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58r/ScienceBioTechnologyPeptides for Muscle Growth: A Preclinical Literature Review (CJC/Ipamorelin, PEG...jimmytwoshoes42010%37.5induced pluripotent stem cells2026-03-17↗
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59r/jenova_aiBest AI for Grading Assistant: Transform Assessment Workflows and Reclaim 6+ Wee...Rude-Result736210%37.5induced pluripotent stem cells2026-03-08↗
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60r/hospitalistVirus - PropagationNeither-Objective2540%137.5induced pluripotent stem cells2026-04-01↗
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u/Emergency-Cold7615But do the hosts turn into zombies? ?negative1
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61r/Scholar[Article] Maintenance of Human Naïve Pluripotent Stem Cellsxxx_laevis10%231.8induced pluripotent stem cells2026-03-20↗
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u/AutoModeratorDear /u/xxx_laevis, Thank you for your submission! Please read the following. Reply to the fulfiller with "thanks solution verified" once your request has been found. Chances are high that the article you're looking for is already available! Search for its DOI/PMID/title here, or DOI/PMID/URL here. If this answers your request, please flair your post as Found. If your article is not available via Sci-Hub/Libgen, be sure to provide us a full citation, a DOI or PMID or at least the ISSN of the journal, and a link to the paywall or PubMed record or, if you can't find one, a link to the journal's WorldCat record. If your article is not available online, flair your post as Needs Digitizing. If your request isn't urgent, please try an interlibrary loan (ILL) instead. ILL avoids potential copyright issues and lets libraries know which subscriptions are useful. If you receive a PM from someone asking you to pay for the article, please understand that this is against the spirit of the sub and we do not condone this. Message the mods if you believe it to be a scam. Fulfill some requests while you wait for yours! I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.neutral1
u/GD4E1https://www.mediafire.com/file/0v4xly8a30ujjod/978-1-0716-1908-7.pdf/fileneutral1
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62r/McatSection bank 1 B/B questionMaximum-Fishing-898930%127.3induced pluripotent stem cells2026-04-02↗
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u/SatisfactionOk6367For the question don’t worry about tnfalpha, just strictly look at the graph and compare. Of all the results, RBSP has the most apoptosis meaning most dead cells meaning the least fluorescence. Don’t read too much into the question, just look at the graph and solely interpret what it means. Only if it mentioned TNFalpha would you interpret the results differently, but this question is more straightforward. Lmk if that helps!negative2
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63r/DailyslantInteresting this Pluripotent Stem Cells isOGBFREE20%25.5induced pluripotent stem cells2026-04-01↗